CN104383037A - Anti-cerebral-thrombosis tablets and preparation method thereof - Google Patents
Anti-cerebral-thrombosis tablets and preparation method thereof Download PDFInfo
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- A61K2236/30—Extraction of the material
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Abstract
The invention discloses anti-cerebral-thrombosis tablets and a preparation method thereof. The anti-cerebral-thrombosis tablets are characterized by comprising the following components in parts by weight: 90g of safflower, 90g of Chinese angelica, 90g of leeches, 90g of red paeony root, 90g of peach seed, 90g of szechuan lovage rhizome, 90g of salvia miltiorrhiza, 18g of Chinese azalea flower and 50g of Chinese atractylode rhizome. The preparation method comprises the following steps: extracting the components by adopting a carbon dioxide supercritical extraction process, performing reduced pressure drying, crushing into nano dry paste by using a high-energy nano impact mill, and adding functional auxiliary materials to prepare the anti-cerebral-thrombosis tablets. The anti-cerebral-thrombosis tablets disclosed by the invention can be used for significantly shortening the disintegration time, and have the curative effects significantly superior to that of commercially-available anti-cerebral-thrombosis tablets, and thus positive effects can be achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of NAOXUESHUAN PIAN and preparation method thereof.
Background technology
NAOXUESHUAN PIAN blood circulation promoting and blood stasis dispelling, brain-refreshing and channel obstruction-removing, suppressing hyper-yang to eliminate wind.For the premonitory apoplexy because of blood stasis, excessive rising of liver-YANG appearance, as numb limbs and tense tendons, the disease such as aphasia due to apoplexy, facial hemiparalysis, hemiplegia occurred with cerebral thrombosis such as to have a dizzy spell.There is preventive and therapeutic action.Existing NAOXUESHUAN PIAN is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides NAOXUESHUAN PIAN that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Flos Carthami 90g, Radix Angelicae Sinensis 90g, Hirudo 90g, Radix Paeoniae Rubra 90g, Semen Persicae 90g, Rhizoma Chuanxiong 90g, Radix Salviae Miltiorrhizae 90g, Flos Rhododendri Mollis 18g, Rhizoma Atractylodis 50g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 40Mpa, extraction temperature 20 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 40 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 20 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add pregelatinized Starch 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, crospolyvinylpyrrolidone 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, hypromellose 25 ~ 35g, micropowder silica gel 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, lactose 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, be pressed into 1000, obtained NAOXUESHUAN PIAN.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Flos Carthami: China's coastal port one ministerial standard.This product is the dried floral of feverfew Flos Carthami Carthamus tinctorius L..Pluck when summer, flower was red by xanthochromia, dry in the shade or dry.
Radix Angelicae Sinensis: China's coastal port one ministerial standard.This product is umbelliferae angelica Angelica sinensis(Oliv.) dry root of Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.
Hirudo: China's coastal port one ministerial standard.This product is that the drying of Hirudinidae animal whitmania Wbitmania pigra Whitman, Hylarana guentheri Hirudo nipponica Whitman or Folium Salicis Babylonicae Hirudo Wbitmania ac-ranulata Whitman is all.Summer, Qiu Erji catch, and scald dead, dry or cold drying with boiling water.
Radix Paeoniae Rubra: China's coastal port one ministerial standard.This product is the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Spring, Qiu Erji excavate, and removing rhizome, fibrous root and silt, dry.
Semen Persicae: China's coastal port one ministerial standard.This product is rosaceous plant Fructus Persicae Prunus persica(L.) Batsch or Prunus davidiana Prunus davidiana(Cars.) dry mature seed of Franch..Gather after fruit maturation, removing sarcocarp and nucleocapsid, take out seed, dry.
Rhizoma Chuanxiong: China's coastal port one ministerial standard.This product is the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanriong Hort..The joint dish that summer works as on stem is significantly outstanding, and excavates during purplish, and removing silt, shines post-drying, then remove fibrous root.
Radix Salviae Miltiorrhizae: China's coastal port one ministerial standard.This product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Spring, Qiu Erji excavate, removing silt, dry.
Flos Rhododendri Mollis: China's coastal port one ministerial standard.This product is the dried floral of ericad rhododendron molle (bl.) g.don Rhododendron molleG.Don.Gather when four, opening at the beginning of May Flower, dry in the shade or dry.
Rhizoma Atractylodis: China's coastal port one ministerial standard.This product is feverfew Atractylodes lancea (Thunb.) DC. Atractylode lancea(Thunb.) DC. or Atractylis chinensis Atracctylodes chinensis(DC.) Koidz.Dry rhizome.Spring, Qiu Erji excavate, and removing silt, dries, hit fibrous root.
Pregelatinized Starch: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Hypromellose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Micropowder silica gel: Chinese Pharmacopoeia version two ministerial standard in 2010.
Sodium chloride: Chinese Pharmacopoeia version two ministerial standard in 2010.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
Lactose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Carboxymethylstach sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.
Magnesium stearate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above NAOXUESHUAN PIAN all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Flos Carthami 90g, Radix Angelicae Sinensis 90g, Hirudo 90g, Radix Paeoniae Rubra 90g, Semen Persicae 90g, Rhizoma Chuanxiong 90g, Radix Salviae Miltiorrhizae 90g, Flos Rhododendri Mollis 18g, Rhizoma Atractylodis 50g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20Mpa, extraction temperature 20 DEG C, separator pressure 10Mpa, separator temperature 40 DEG C, disengaging time 2 hours, carbon dioxide flow 20L per hour, obtains extracting solution; Get extracting solution 60 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add pregelatinized Starch 80g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35g, crospolyvinylpyrrolidone 35g, cross-linking sodium carboxymethyl cellulose 35g, hypromellose 25g, micropowder silica gel 15g, sodium chloride 5g, mannitol 4g, lactose 4g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional carboxymethyl starch sodium 7g, magnesium stearate 1g, granulate, be pressed into 1000, obtained NAOXUESHUAN PIAN.
Specific embodiments of the invention 2
Get Flos Carthami 90g, Radix Angelicae Sinensis 90g, Hirudo 90g, Radix Paeoniae Rubra 90g, Semen Persicae 90g, Rhizoma Chuanxiong 90g, Radix Salviae Miltiorrhizae 90g, Flos Rhododendri Mollis 18g, Rhizoma Atractylodis 50g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 40Mpa, extraction temperature 40 DEG C, separator pressure 20Mpa, separator temperature 60 DEG C, disengaging time 4 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get extracting solution 80 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add pregelatinized Starch 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, crospolyvinylpyrrolidone 45g, cross-linking sodium carboxymethyl cellulose 45g, hypromellose 35g, micropowder silica gel 25g, sodium chloride 15g, mannitol 6g, lactose 6g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional carboxymethyl starch sodium 9g, magnesium stearate 3g, granulate, be pressed into 1000, obtained NAOXUESHUAN PIAN.
Specific embodiments of the invention 3
Get Flos Carthami 90g, Radix Angelicae Sinensis 90g, Hirudo 90g, Radix Paeoniae Rubra 90g, Semen Persicae 90g, Rhizoma Chuanxiong 90g, Radix Salviae Miltiorrhizae 90g, Flos Rhododendri Mollis 18g, Rhizoma Atractylodis 50g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 30 DEG C, separator pressure 15Mpa, separator temperature 50 DEG C, disengaging time 3 hours, carbon dioxide flow 30L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add pregelatinized Starch 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, crospolyvinylpyrrolidone 40g, cross-linking sodium carboxymethyl cellulose 40g, hypromellose 30g, micropowder silica gel 20g, sodium chloride 20g, mannitol 5g, lactose 5g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, be pressed into 1000, obtained NAOXUESHUAN PIAN.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make NAOXUESHUAN PIAN.Actual effect of the present invention is investigated below with the NAOXUESHUAN PIAN that embodiment 3 is obtained:
(1) embodiment 3 NAOXUESHUAN PIAN and commercially available NAOXUESHUAN PIAN contrast disintegration
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 NAOXUESHUAN PIAN and commercially available NAOXUESHUAN PIAN contrast table disintegration
The above results shows, NAOXUESHUAN PIAN prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available NAOXUESHUAN PIAN.
(2) embodiment 3 NAOXUESHUAN PIAN and commercially available NAOXUESHUAN PIAN treat the premonitory apoplexy because of blood stasis, excessive rising of liver-YANG appearance, as numb limbs and tense tendons, the disease clinical observation on the therapeutic effect such as aphasia due to apoplexy, facial hemiparalysis, hemiplegia occurred with cerebral thrombosis such as to have a dizzy spell
1 case scenario
Statistics outpatient service and inpatient, observes the premonitory apoplexy because of blood stasis, excessive rising of liver-YANG appearances altogether, as routine in numb limbs and tense tendons, the disease case 102 such as aphasia due to apoplexy, facial hemiparalysis, hemiplegia that occurs with cerebral thrombosis such as to have a dizzy spell, 56 years old mean age.Patient is divided into two groups, test group takes embodiment 3 NAOXUESHUAN PIAN, and matched group takes commercially available NAOXUESHUAN PIAN.
2 efficacy assessment standards
According to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 NAOXUESHUAN PIAN and commercially available NAOXUESHUAN PIAN clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, NAOXUESHUAN PIAN prepared by the present invention is at the premonitory apoplexy for the treatment of because of blood stasis, excessive rising of liver-YANG appearance, as numb limbs and tense tendons, to have a dizzy spell etc. the disease such as aphasia due to apoplexy, facial hemiparalysis, hemiplegia occurred with cerebral thrombosis time, evident in efficacy higher than commercially available NAOXUESHUAN PIAN, p < 0.05.
Claims (3)
1. a treatment is because of blood stasis, the premonitory apoplexy of excessive rising of liver-YANG appearance, as numb limbs and tense tendons, to have a dizzy spell etc. and aphasia due to apoplexy that cerebral thrombosis occurs, facial hemiparalysis, the Chinese medicine of the diseases such as hemiplegia, it is characterized in that getting Flos Carthami 90g, Radix Angelicae Sinensis 90g, Hirudo 90g, Radix Paeoniae Rubra 90g, Semen Persicae 90g, Rhizoma Chuanxiong 90g, Radix Salviae Miltiorrhizae 90g, Flos Rhododendri Mollis 18g, Rhizoma Atractylodis 50g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 20 ~ 40Mpa, extraction temperature 20 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 40 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 20 ~ 40L per hour, obtain extracting solution, get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract, get dry cream and add pregelatinized Starch 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm, get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, crospolyvinylpyrrolidone 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, hypromellose 25 ~ 35g, micropowder silica gel 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, lactose 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, suppresses to obtain NAOXUESHUAN PIAN.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Flos Carthami 90g, Radix Angelicae Sinensis 90g, Hirudo 90g, Radix Paeoniae Rubra 90g, Semen Persicae 90g, Rhizoma Chuanxiong 90g, Radix Salviae Miltiorrhizae 90g, Flos Rhododendri Mollis 18g, Rhizoma Atractylodis 50g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 20 ~ 40Mpa, extraction temperature 20 ~ 40 DEG C, separator pressure 10 ~ 20Mpa, separator temperature 40 ~ 60 DEG C, disengaging time 2 ~ 4 hours, carbon dioxide flow 20 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 DEG C ~ 80 DEG C drying under reduced pressure, get dry extract; Get dry cream and add pregelatinized Starch 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, crospolyvinylpyrrolidone 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, hypromellose 25 ~ 35g, micropowder silica gel 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, lactose 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, magnesium stearate 1 ~ 3g, granulate, suppresses to obtain NAOXUESHUAN PIAN.
3. the preparation method of Chinese medicine according to claim 1, gets Flos Carthami 90g, Radix Angelicae Sinensis 90g, Hirudo 90g, Radix Paeoniae Rubra 90g, Semen Persicae 90g, Rhizoma Chuanxiong 90g, Radix Salviae Miltiorrhizae 90g, Flos Rhododendri Mollis 18g, Rhizoma Atractylodis 50g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 30 DEG C, separator pressure 15Mpa, separator temperature 50 DEG C, disengaging time 3 hours, carbon dioxide flow 30L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add pregelatinized Starch 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, crospolyvinylpyrrolidone 40g, cross-linking sodium carboxymethyl cellulose 40g, hypromellose 30g, micropowder silica gel 20g, sodium chloride 20g, mannitol 5g, lactose 5g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, magnesium stearate 2g, granulate, suppresses to obtain NAOXUESHUAN PIAN.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110028576A (en) * | 2019-04-12 | 2019-07-19 | 海安华达石油仪器有限公司 | A method of leech is extracted with supercritical carbon dioxide |
-
2014
- 2014-12-03 CN CN201410716962.7A patent/CN104383037A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110028576A (en) * | 2019-04-12 | 2019-07-19 | 海安华达石油仪器有限公司 | A method of leech is extracted with supercritical carbon dioxide |
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| WW01 | Invention patent application withdrawn after publication |