CN105343676A - Tablet capable of clearing way heat and toxic materials and preparation method thereof - Google Patents

Tablet capable of clearing way heat and toxic materials and preparation method thereof Download PDF

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Publication number
CN105343676A
CN105343676A CN201510905085.2A CN201510905085A CN105343676A CN 105343676 A CN105343676 A CN 105343676A CN 201510905085 A CN201510905085 A CN 201510905085A CN 105343676 A CN105343676 A CN 105343676A
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radix
carbon dioxide
dry
ground
extracting solution
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不公告发明人
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Heilongjiang Jiangheng Pharmaceutical Co Ltd
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Heilongjiang Jiangheng Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a tablet capable of clearing way heat and toxic materials and a preparation method thereof. The tablet capable of clearing way heat and toxic materials is characterized in that 59 g of great burdock achene, 118 g of coix seeds, 29.5 g of fruits of Chinese horsechestnut, 649 g of gypsum, 134 g of honeysuckle, 118 g of radix scrophulariae, 72 g of rehmannia roots, 59 g of forsythia suspense, 59 g of fructus gardeniae, 67 g of radix scutellariae and 59 g of radix gentianae are taken, a carbon dioxide supercritical extraction method is adopted for extraction, drying is performed under reduced pressure, the raw materials are smashed into nanometer dry paste through a high-energy nanometer impacting mill, functional auxiliary materials are added, the tablet capable of clearing way heat and toxic materials is prepared, the disintegration time is remarkably shortened, the curative effect of the tablet is remarkably superior to that of tablets, sold in the market, capable of clearing way heat and toxic materials, and a positive effect is achieved.

Description

A kind of Qingrejiedu tablets and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Qingrejiedu tablets and preparation method thereof.
Background technology
Qingrejiedu tablets heat-clearing and toxic substances removing.Be used for the treatment of influenza, upper respiratory tract infection and various febrile disease.Commercially available Qingrejiedu tablets is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides Qingrejiedu tablets that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Fructus Arctii 59g, Semen Coicis 118g, Semen Aesculi 29.5g, Gypsum Fibrosum 649g, Flos Lonicerae 134g, Radix Scrophulariae 118g, Radix Rehmanniae 72g, Fructus Forsythiae 59g, Fructus Gardeniae 59g, Radix Scutellariae 67g, Radix Gentianae 59g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 18 ~ 41Mpa, extraction temperature 25 ~ 36 DEG C, separator pressure 13 ~ 19Mpa, separator temperature 43 ~ 53 DEG C, disengaging time 1.8 ~ 3.7 hours, carbon dioxide flow 25 ~ 40L per hour, obtains extracting solution; Get extracting solution 63 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, hyprolose 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, aluminium-magnesium silicate 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, maltodextrin 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional sodium alginate 7 ~ 9g, boric acid 1 ~ 3g, granulate, tabletting, obtained Qingrejiedu tablets 1500.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Fructus Arctii: China's coastal port one ministerial standard.This product is the dry mature fruit of feverfew Fructus Arctii ArctiumlaPPaL..To gather during fruit maturation in autumn infructescence, dry, lay fruit, removing impurity dries again.
Semen Coicis: China's coastal port one ministerial standard.This product is grass Semen Coicis Coixlacryma-jobiL.var.ma-yuen(ROman.) dry mature kernal of Stapf.Tap plant during fruit maturation in autumn, dry, lay fruit, then dry, except decapsidate, yellowish-brown seed coat and impurity, collect kernel.
Semen Aesculi: Chinese Pharmacopoeia version one ministerial standard in 2010.This product is the dry mature seed that Hippocastanaceae plant Aesculus chinensis Bunge AescwZwchinensisBge., Zhejiang seven B ten set AesculuschinensisBge.var.chekiangensis (HuetFang) FangM^zMMAesculuswilsoniiRehd..Gather during fruit maturation in autumn, removing peel, dries or cold drying.
Gypsum Fibrosum: China's coastal port one ministerial standard.This product is Sulfates mineral anhydrite race Gypsum Fibrosum, after master excavates containing hydrous calcium sulfate (CaSO42H2O), and removing silt and assorted stone.
Flos Lonicerae: China's coastal port one ministerial standard.This product is dry flower or the first flower opened of band of caprifoliaceae plant Radix Ophiopogonis LonicerajaponicaThunb..Early summer the flowers are in blossom put before gather, dry.
Radix Scrophulariae: China's coastal port one ministerial standard.This product is the dry root of goatweed Radix Scrophulariae ScrophularianingpoensisHemsl..Excavate when winter, stem and leaf was withered, removing rhizome, plumelet, fibrous root and silt, shine or be dried to half-dried, stacks 3-6 days, repeatedly for several times to dry.
Radix Rehmanniae: China's coastal port one ministerial standard.This product is the fresh of scrophulariaceae rehmannia glutinosa plant RehmanniaglutinosaLibosch. or dried root.Autumn excavates, except removing LU, fibrous root and silt, and using fresh herb; Or Radix Rehmanniae is slowly cured to about most probably dry.The former practises title " Radix Rehmanniae ", and the latter practises title " Radix Rehmanniae ".
Fructus Forsythiae: China's coastal port one ministerial standard.This product is Oleaceae plants Fructus Forsythiae Forsythiasuspensa(Thnub.) dry fruit of Vahl.Gather during fruit in autumn first ripe still band green. except decontamination, cook, dry, practise and claim " green grass or young crops sticks up "; Gather when fruit is well-done, dry. except decontamination, practise and claim " always sticking up ".
Fructus Gardeniae: China's coastal port one ministerial standard.This product is the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae GardeniajasminoidesEllis.Gather when the 9-11 month, fruit maturation was reddish yellow, removing carpopodium and impurity, steam supreme vapour or put in boiling water and slightly scald, take out, dry.
Radix Scutellariae: China's coastal port one ministerial standard.This product is the dry root of labiate Radix Scutellariae ScutellariabaicalensisGeorgi.Spring, Qiu Erji excavate, and removing fibrous root and silt, hit rough bark after solarization, dry.
Radix Gentianae: China's coastal port one ministerial standard.This product is gentianaceae plant Gentiana manshurica GentianamanshuricaKitag, Radix Gentianae GentianascabraBge., G. triflora Gentianatriflorapall.Or the dry root and rhizome of Gentiana rigescens Franch GentianarigescensFranch..First three is planted to practise and claims " Radix Gentianae ", and rear one is practised and being claimed " hard dragon clothes ".Spring, Qiu Erji dig, cleaning, drying.
Citric acid: Chinese Pharmacopoeia version two ministerial standard in 2010.
Microcrystalline Cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Hyprolose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Cross-linking sodium carboxymethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Aluminium-magnesium silicate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Sodium chloride: Chinese Pharmacopoeia version two ministerial standard in 2010.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
Maltodextrin: Chinese Pharmacopoeia version two ministerial standard in 2010.
Sodium alginate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Boric acid: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above Qingrejiedu tablets all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Fructus Arctii 59g, Semen Coicis 118g, Semen Aesculi 29.5g, Gypsum Fibrosum 649g, Flos Lonicerae 134g, Radix Scrophulariae 118g, Radix Rehmanniae 72g, Fructus Forsythiae 59g, Fructus Gardeniae 59g, Radix Scutellariae 67g, Radix Gentianae 59g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 18Mpa, extraction temperature 25 DEG C, separator pressure 13Mpa, separator temperature 43 DEG C, disengaging time 1.8 hours, carbon dioxide flow 25L per hour, obtains extracting solution; Get extracting solution 63 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35g, hyprolose 35g, cross-linking sodium carboxymethyl cellulose 35g, aluminium-magnesium silicate 15g, sodium chloride 5g, mannitol 4g, maltodextrin 4g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional sodium alginate 7g, boric acid 1g, granulate, tabletting, obtained Qingrejiedu tablets 1500.
Specific embodiments of the invention 2
Get Fructus Arctii 59g, Semen Coicis 118g, Semen Aesculi 29.5g, Gypsum Fibrosum 649g, Flos Lonicerae 134g, Radix Scrophulariae 118g, Radix Rehmanniae 72g, Fructus Forsythiae 59g, Fructus Gardeniae 59g, Radix Scutellariae 67g, Radix Gentianae 59g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 41Mpa, extraction temperature 36 DEG C, separator pressure 19Mpa, separator temperature 53 DEG C, disengaging time 3.7 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get extracting solution 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 45g, hyprolose 45g, cross-linking sodium carboxymethyl cellulose 45g, aluminium-magnesium silicate 25g, sodium chloride 15g, mannitol 6g, maltodextrin 6g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional sodium alginate 9g, boric acid 3g, granulate, tabletting, obtained Qingrejiedu tablets 1500.
Specific embodiments of the invention 3
Get Fructus Arctii 59g, Semen Coicis 118g, Semen Aesculi 29.5g, Gypsum Fibrosum 649g, Flos Lonicerae 134g, Radix Scrophulariae 118g, Radix Rehmanniae 72g, Fructus Forsythiae 59g, Fructus Gardeniae 59g, Radix Scutellariae 67g, Radix Gentianae 59g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 31 DEG C, separator pressure 16Mpa, separator temperature 48 DEG C, disengaging time 2.8 hours, carbon dioxide flow 33L per hour, obtains extracting solution; Get extracting solution 71 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, hyprolose 40g, cross-linking sodium carboxymethyl cellulose 40g, aluminium-magnesium silicate 20g, sodium chloride 10g, mannitol 5g, maltodextrin 5g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional sodium alginate 8g, boric acid 2g, granulate, tabletting, obtained Qingrejiedu tablets 1500.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make Qingrejiedu tablets.
Actual effect of the present invention is investigated below with the Qingrejiedu tablets that embodiment 3 is obtained:
(1) embodiment 3 Qingrejiedu tablets and contrast disintegration of commercially available Qingrejiedu tablets
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 Qingrejiedu tablets and commercially available Qingrejiedu tablets contrast table disintegration
The above results shows, Qingrejiedu tablets prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available Qingrejiedu tablets.
(2) embodiment 3 Qingrejiedu tablets and commercially available Qingrejiedu tablets treatment treatment influenza, upper respiratory tract infection and various febrile disease clinical observation on the therapeutic effect
1 case scenario
Statistics outpatient service and inpatient, observe treatment influenza altogether, upper respiratory tract infection and various febrile disease case 129 example, 38 years old mean age.Patient is divided into two groups, test group takes embodiment 3 Qingrejiedu tablets, and matched group takes commercially available Qingrejiedu tablets.
2 efficacy assessment standards
According to new Chinese medicine treatment guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 Qingrejiedu tablets and commercially available Qingrejiedu tablets clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, Qingrejiedu tablets prepared by the present invention is in treatment treatment influenza, when upper respiratory tract infection and various febrile disease, evident in efficacy higher than commercially available Qingrejiedu tablets, p < 0.05.

Claims (3)

1. a treatment treatment influenza, the Chinese medicine of upper respiratory tract infection and various febrile disease, it is characterized in that getting Fructus Arctii 59g, Semen Coicis 118g, Semen Aesculi 29.5g, Gypsum Fibrosum 649g, Flos Lonicerae 134g, Radix Scrophulariae 118g, Radix Rehmanniae 72g, Fructus Forsythiae 59g, Fructus Gardeniae 59g, Radix Scutellariae 67g, Radix Gentianae 59g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 18 ~ 41Mpa, extraction temperature 25 ~ 36 DEG C, separator pressure 13 ~ 19Mpa, separator temperature 43 ~ 53 DEG C, disengaging time 1.8 ~ 3.7 hours, carbon dioxide flow 25 ~ 40L per hour, obtain extracting solution, get extracting solution 63 ~ 79 DEG C of drying under reduced pressure, get dry extract, get dry cream and add citric acid 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm, get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, hyprolose 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, aluminium-magnesium silicate 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, maltodextrin 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional sodium alginate 7 ~ 9g, boric acid 1 ~ 3g, granulate, tabletting, obtained Qingrejiedu tablets.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Fructus Arctii 59g, Semen Coicis 118g, Semen Aesculi 29.5g, Gypsum Fibrosum 649g, Flos Lonicerae 134g, Radix Scrophulariae 118g, Radix Rehmanniae 72g, Fructus Forsythiae 59g, Fructus Gardeniae 59g, Radix Scutellariae 67g, Radix Gentianae 59g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 18 ~ 41Mpa, extraction temperature 25 ~ 36 DEG C, separator pressure 13 ~ 19Mpa, separator temperature 43 ~ 53 DEG C, disengaging time 1.8 ~ 3.7 hours, carbon dioxide flow 25 ~ 40L per hour, obtains extracting solution; Get extracting solution 63 ~ 79 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 80 ~ 120g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 35 ~ 45g, hyprolose 35 ~ 45g, cross-linking sodium carboxymethyl cellulose 35 ~ 45g, aluminium-magnesium silicate 15 ~ 25g, sodium chloride 5 ~ 15g, mannitol 4 ~ 6g, maltodextrin 4 ~ 6g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional sodium alginate 7 ~ 9g, boric acid 1 ~ 3g, granulate, tabletting, obtained Qingrejiedu tablets.
3. the preparation method of Chinese medicine according to claim 1, gets Fructus Arctii 59g, Semen Coicis 118g, Semen Aesculi 29.5g, Gypsum Fibrosum 649g, Flos Lonicerae 134g, Radix Scrophulariae 118g, Radix Rehmanniae 72g, Fructus Forsythiae 59g, Fructus Gardeniae 59g, Radix Scutellariae 67g, Radix Gentianae 59g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 30Mpa, extraction temperature 31 DEG C, separator pressure 16Mpa, separator temperature 48 DEG C, disengaging time 2.8 hours, carbon dioxide flow 33L per hour, obtains extracting solution; Get extracting solution 71 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add citric acid 100g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, microcrystalline Cellulose 40g, hyprolose 40g, cross-linking sodium carboxymethyl cellulose 40g, aluminium-magnesium silicate 20g, sodium chloride 10g, mannitol 5g, maltodextrin 5g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional sodium alginate 8g, boric acid 2g, granulate, tabletting, obtained Qingrejiedu tablets.
CN201510905085.2A 2015-12-10 2015-12-10 Tablet capable of clearing way heat and toxic materials and preparation method thereof Pending CN105343676A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108576427A (en) * 2018-03-02 2018-09-28 安徽宏亮饲料科技有限公司 A kind of additive and preparation method thereof preventing small swine flu

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108576427A (en) * 2018-03-02 2018-09-28 安徽宏亮饲料科技有限公司 A kind of additive and preparation method thereof preventing small swine flu

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