CN104383254A - Tianwang heart-invigorating pill and preparation method thereof - Google Patents

Tianwang heart-invigorating pill and preparation method thereof Download PDF

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Publication number
CN104383254A
CN104383254A CN201410716966.5A CN201410716966A CN104383254A CN 104383254 A CN104383254 A CN 104383254A CN 201410716966 A CN201410716966 A CN 201410716966A CN 104383254 A CN104383254 A CN 104383254A
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radix
pill
heart
powder
dry
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不公告发明人
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Heilongjiang Jiangheng Pharmaceutical Co Ltd
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Heilongjiang Jiangheng Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/69—Polygalaceae (Milkwort family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/79—Schisandraceae (Schisandra family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a Tianwang heart-invigorating pill and a preparation method thereof. The preparation method of the Tianwang heart-invigorating pill is characterized by comprising the following steps: crushing the following raw materials by weight: 25g of divaricate saposhnikovia root, 38g of pokeberry root, 25g of root of salviae miltiorrhiza, 50g of angelica sinensis, 25g of rhizoma acori graminei, 25g of poria cocos, 50g of Chinese magnoliavine fruit, 50g of radix ophiopogonis, 50g of cochinchinese asparagus root, 200g of rehmannia glutinosa libosch, 25g of scrophularia ningpoensis, 25g of polygala tenuifolia, 50g of spina date seed (fried), 50g of platycladi seed and 25g of platycodon grandiflorum into crude powder; putting the crude powder into a circulating ultrasonic device; adding water, germanium powder and Tween-60; carrying out ultrasonic extraction and jet spray drying, so as to prepare nano extract powder; and refining a honey pill, so as to prepare the Tianwang heart-invigorating pill. The Tianwang heart-invigorating pill is used for treating insufficiency of heart yin, palpitation, amnesia, insomnia and dreamful sleep and dry stool; the curative effect is significantly superior to that of the commercially available Tianwang heart-invigorating pill; and a good effect is obtained.

Description

A kind of tianwangbuxin pills and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of tianwangbuxin pills and preparation method thereof.
Background technology
Tianwangbuxin pills is used for insufficiency of heart-YIN, and palpitation and amnesia, insomnia and dreamful sleep, is hard and dry.Commercially available tianwangbuxin pills is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the shortcoming that curative effect is low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides tianwangbuxin pills that a kind of curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Radix Saposhnikoviae 25g, Radix Phytolaccae 38g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 50g, Rhizoma Acori Graminei 25g, Poria 25g, Fructus Schisandrae Chinensis 50g, Radix Ophiopogonis 50g, Radix Asparagi 50g, Radix Rehmanniae 200g, Radix Scrophulariae 25g, Radix Polygalae 25g, Semen Ziziphi Spinosae (stir-fry) 50g, Semen Platycladi 50g, Radix Platycodonis 25g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, obtained tianwangbuxin pills.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Radix Saposhnikoviae: China's coastal port one ministerial standard.This product is umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata(Turcz.) dry root of Schischk..Spring, Qiu Erji excavate the root not taking out scape plant. and removing fibrous root and silt, dry.
Radix Phytolaccae: China's coastal port one ministerial standard.This product is the dry root of Phytolaccaceae plant pokeweed Phstolacca acinosa Roxb. or pokeroot Phytolacca americana L..Autumn dug to time spring, and removing fibrous root and silt, be cut into block or sheet, dry or dry in the shade.
Radix Salviae Miltiorrhizae: China's coastal port one ministerial standard.This product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Spring, Qiu Erji excavate, removing silt, dry.
Radix Angelicae Sinensis: China's coastal port one ministerial standard.This product is umbelliferae angelica Angelica sinensis(Oliv.) dry root of Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.
Rhizoma Acori Graminei: China's coastal port one ministerial standard.This product is the dry rhizome of acorus gramineus araceae plant Acorns tatarinowii Schott.Autumn, each two seasons excavate, and removing must be reported and silt, dries.
Poria: China's coastal port one ministerial standard.This product is On Polyporaceae Poria Poria cocos(Schw.) dry sclerotia of Wolf.Excavate more than the 7-9 month, dig out rear removing silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now scatter and disappear in wrinkle, the large portion of internal moisture for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed different parts cutting, cloudy in, be called " Cortex Sclerotii Poriae " and " Poria block ".
Fructus Schisandrae Chinensis: China's coastal port one ministerial standard.This product is magnoliaceae schisandra Schisandra chfnensis(Turcz.) dry mature fruit of Baill., practise and claim " Radix Schisandrae Bicoloris ".Pluck during fruit maturation in autumn, dry or dry after steaming, removing carpopodium and impurity.
Radix Ophiopogonis: China's coastal port one ministerial standard.This product is liliaceous plant Ophiopogon Radix Ophiopogonis japonicus(Thunb.) dried root of Ker-Gawl..Summer excavates, and cleans, is repeatedly exposed to the sun, banks up. and to very likely in, removing fibrous root, dry.
Radix Asparagi: China's coastal port one ministerial standard.This product is liliaceous plant Radix Asparagi Asparagus cochinchinensis(Lour.) dried root of Merr..Autumn, season in winter two excavate, and clean, remove stem foot and fibrous root, put in boiling water and boil or steam to the saturating heart, remove crust while hot, cleaning, drying.
Radix Rehmanniae: China's coastal port one ministerial standard.This product is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Autumn excavates, except removing LU, fibrous root and silt, and using fresh herb; Or Radix Rehmanniae is slowly cured to about most probably dry.The former practises title " Radix Rehmanniae ", and the latter practises title " Radix Rehmanniae ".
Radix Scrophulariae: China's coastal port one ministerial standard.This product is the dry root of goatweed Radix Scrophulariae Scrophularia ningpoensisHemsl..Excavate when winter, stem and leaf was withered, removing rhizome, plumelet, fibrous root and silt, shine or be dried to half-dried, stacks 3-6 days, repeatedly for several times to dry.
Radix Polygalae: China's coastal port one ministerial standard.This product is the dry root of milk wort Radix Polygalae Polyyala tenuifolia Willd. or ovum leaf Radix Polygalae Polygala sibirica L..Spring, Qiu Erji excavate. and removing fibrous root and silt, dry.
Semen Ziziphi Spinosae (stir-fry): China's coastal port one ministerial standard.This product is Rhamnaceae plant Ziziphi Spinosae Ziziphus jujuba Mill. var. spinosa(Bunge) dry mature seed of Hu ex H.F.Chou.Time of the year when autumn changes into winter gathers mature fruit, removing sarcocarp and nucleocapsid, collects seed, dries.
Semen Platycladi: China's coastal port one ministerial standard.This product is Cupressaceae plant Cacumen Platycladi Platycladus orientalis(L.) dry mature kernal of Franco.Autumn, season in winter two receive mature seed, dry. removing seed coat. collect kernel.
Radix Platycodonis: China's coastal port one ministerial standard.This product is Campanulaceae Radix Platycodonis Platycodon grandiflorum(Jacq.) dry root of A DC..Spring, Qiu Erji excavate, and clean, and removing fibrous root, takes advantage of and freshly peel off crust or do not remove crust, dry.
Germanium powder: germanium dioxide: No. CAS: 1310-53-8: industry standard: lark prestige Science and Technology Ltd.;
Polysorbate60: Chinese Pharmacopoeia version two ministerial standard in 2010;
Raw material used by above tianwangbuxin pills all can be bought from pharmaceuticals and obtain, and is not limited to typical production producer, all can be used to implement the present invention program as long as meet quality standard.
The key equipment that foregoing invention embodiment is mentioned is as follows:
Circulating ultrasonic machine: supersonic frequency 20 ~ 100KHz,
(typical production producer: Beijing Hongxianglong Biotechnology Development Co., Ltd)
Jet spray dryer: inlet temperature scope 30 ~ 70 DEG C, 300 ~ 900 meters per second of effluxvelocity scope;
(typical production producer: Nai Nuo bio tech ltd, Beijing)
Raw material used by above tianwangbuxin pills all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Detailed description of the invention
Specific embodiments of the invention 1
Get Radix Saposhnikoviae 25g, Radix Phytolaccae 38g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 50g, Rhizoma Acori Graminei 25g, Poria 25g, Fructus Schisandrae Chinensis 50g, Radix Ophiopogonis 50g, Radix Asparagi 50g, Radix Rehmanniae 200g, Radix Scrophulariae 25g, Radix Polygalae 25g, Semen Ziziphi Spinosae (stir-fry) 50g, Semen Platycladi 50g, Radix Platycodonis 25g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 4g germanium powder, 6g polysorbate60, select supersonic frequency 50KHz, pressure 0.3Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 DEG C, pressure 0.02Mpa, 400 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20g adds appropriate water pill, dry, makes water-honeyed pill, obtained tianwangbuxin pills.
Specific embodiments of the invention 2
Get Radix Saposhnikoviae 25g, Radix Phytolaccae 38g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 50g, Rhizoma Acori Graminei 25g, Poria 25g, Fructus Schisandrae Chinensis 50g, Radix Ophiopogonis 50g, Radix Asparagi 50g, Radix Rehmanniae 200g, Radix Scrophulariae 25g, Radix Polygalae 25g, Semen Ziziphi Spinosae (stir-fry) 50g, Semen Platycladi 50g, Radix Platycodonis 25g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 6g germanium powder, 8g polysorbate60, select supersonic frequency 60KHz, pressure 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 50 DEG C, pressure 0.04 Mpa, 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 30g adds appropriate water pill, dry, makes water-honeyed pill, obtained tianwangbuxin pills.
Specific embodiments of the invention 3
Get Radix Saposhnikoviae 25g, Radix Phytolaccae 38g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 50g, Rhizoma Acori Graminei 25g, Poria 25g, Fructus Schisandrae Chinensis 50g, Radix Ophiopogonis 50g, Radix Asparagi 50g, Radix Rehmanniae 200g, Radix Scrophulariae 25g, Radix Polygalae 25g, Semen Ziziphi Spinosae (stir-fry) 50g, Semen Platycladi 50g, Radix Platycodonis 25g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 5g germanium powder, 7g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 25g adds appropriate water pill, dry, makes water-honeyed pill, obtained tianwangbuxin pills.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make tianwangbuxin pills.Actual effect of the present invention is investigated below with the tianwangbuxin pills that embodiment 3 is obtained:
(1) embodiment 3 tianwangbuxin pills and commercially available tianwangbuxin pills treat insufficiency of heart-YIN, palpitation and amnesia, insomnia and dreamful sleep, clinical observation on the therapeutic effect of being hard and dry
1 case scenario
Statistics outpatient service and inpatient, observe insufficiency of heart-YIN, palpitation and amnesia, insomnia and dreamful sleep altogether, case of being hard and dry 100 example, 35 years old mean age.Patient is divided into two groups, test group takes embodiment 3 tianwangbuxin pills, and matched group takes traditional tianwangbuxin pills.
2 efficacy assessment standards
According to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard:
Cure: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 1 embodiment 3 tianwangbuxin pills and the contrast of commercially available tianwangbuxin pills clinical efficacy
Above-mentioned clinical observation on the therapeutic effect result shows, tianwangbuxin pills prepared by the present invention is treating insufficiency of heart-YIN, palpitation and amnesia, insomnia and dreamful sleep, when being hard and dry, evident in efficacy higher than commercially available tianwangbuxin pills, p < 0.05.

Claims (3)

1. a treatment insufficiency of heart-YIN, palpitation and amnesia, insomnia and dreamful sleep, the Chinese medicine of being hard and dry, it is characterized in that getting Radix Saposhnikoviae 25g, Radix Phytolaccae 38g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 50g, Rhizoma Acori Graminei 25g, Poria 25g, Fructus Schisandrae Chinensis 50g, Radix Ophiopogonis 50g, Radix Asparagi 50g, Radix Rehmanniae 200g, Radix Scrophulariae 25g, Radix Polygalae 25g, Semen Ziziphi Spinosae (stir-fry) 50g, Semen Platycladi 50g, Radix Platycodonis 25g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution, getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder, every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, obtained tianwangbuxin pills.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Radix Saposhnikoviae 25g, Radix Phytolaccae 38g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 50g, Rhizoma Acori Graminei 25g, Poria 25g, Fructus Schisandrae Chinensis 50g, Radix Ophiopogonis 50g, Radix Asparagi 50g, Radix Rehmanniae 200g, Radix Scrophulariae 25g, Radix Polygalae 25g, Semen Ziziphi Spinosae (stir-fry) 50g, Semen Platycladi 50g, Radix Platycodonis 25g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 4 ~ 6g germanium powder, 6 ~ 8g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 20-30g adds appropriate water pill, dry, makes water-honeyed pill, obtained tianwangbuxin pills.
3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Radix Saposhnikoviae 25g, Radix Phytolaccae 38g, Radix Salviae Miltiorrhizae 25g, Radix Angelicae Sinensis 50g, Rhizoma Acori Graminei 25g, Poria 25g, Fructus Schisandrae Chinensis 50g, Radix Ophiopogonis 50g, Radix Asparagi 50g, Radix Rehmanniae 200g, Radix Scrophulariae 25g, Radix Polygalae 25g, Semen Ziziphi Spinosae (stir-fry) 50g, Semen Platycladi 50g, Radix Platycodonis 25g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 7130g water, 5g germanium powder, 7g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Every 100g nanometer extract powder refined honey 25g adds appropriate water pill, dry, makes water-honeyed pill, obtained tianwangbuxin pills.
CN201410716966.5A 2014-12-03 2014-12-03 Tianwang heart-invigorating pill and preparation method thereof Withdrawn CN104383254A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105148144A (en) * 2015-09-22 2015-12-16 麻翠秋 Foot bathing liquid capable of promoting brain fitness and intelligence reinforcement
CN106236721A (en) * 2016-08-31 2016-12-21 太极集团浙江东方制药有限公司 A kind of preparation method of Guishaoliujun Pill

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105148144A (en) * 2015-09-22 2015-12-16 麻翠秋 Foot bathing liquid capable of promoting brain fitness and intelligence reinforcement
CN106236721A (en) * 2016-08-31 2016-12-21 太极集团浙江东方制药有限公司 A kind of preparation method of Guishaoliujun Pill

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Application publication date: 20150304