CN105343509A - Yuquan capsules and preparation method thereof - Google Patents
Yuquan capsules and preparation method thereof Download PDFInfo
- Publication number
- CN105343509A CN105343509A CN201510914183.2A CN201510914183A CN105343509A CN 105343509 A CN105343509 A CN 105343509A CN 201510914183 A CN201510914183 A CN 201510914183A CN 105343509 A CN105343509 A CN 105343509A
- Authority
- CN
- China
- Prior art keywords
- radix
- yuquan
- carbon dioxide
- ground
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses Yuquan capsules and a preparation method thereof. The Yuquan capsules are characterized in that 144 g of styrax, 288 g of nardostachys jatamansi DC., 22 g of cortex Lycii, 200 g of Chinese trichosanthes roots, 133 g of radix ophiopogonis, 120 g of ginseng, 144 g of poria cocos, 144 g of dark plum fruits, 133 g of milkvetch roots and 144 g of liquorice are taken, extracted through a carbon dioxide supercritical extraction method, subjected to pressure-reducing drying and smashed into nanometer dry paste through a high-energy nanometer impacting grinder, functional auxiliary materials are added, and then the Yuquan capsules are prepared. The disintegration time is obviously shortened, the treatment effect is obviously better than that of Yuquan capsules sold in the market, and a positive effect is achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of Yuquan capsule and preparation method thereof.
Background technology
Yuquan capsule Replenishing QI and nourishing YIN, promoting the production of body fluid to quench thirst, clearing heat and relieving fidgetness.Cure mainly deficiency of both vital energy and Yin, thirsty polydipsia, help digestion polyphagia; The above-mentioned patient of diabetes spp.Commercially available Yuquan capsule is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the deficiencies such as prolonged disintegration, curative effect are low.
Summary of the invention
The present invention, for overcoming above-mentioned deficiency, provides Yuquan capsule that a kind of disintegration rate is fast, curative effect is high and preparation method thereof.
Invention embodiment is as follows:
Get Styrax 144g, Radix Et Rhizoma Nardostachyos 288g, Cortex Lycii 22g, Radix Trichosanthis 200g, Radix Ophiopogonis 133g, Radix Ginseng 120g, Poria 144g, Fructus Mume 144g, Radix Astragali 133g, Radix Glycyrrhizae 144g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 16 ~ 37Mpa, extraction temperature 21 ~ 43 DEG C, separator pressure 13 ~ 19Mpa, separator temperature 41 ~ 53 DEG C, disengaging time 2.6 ~ 3.5 hours, carbon dioxide flow 25 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 ~ 80 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, L MALIC ACID 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, ethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, calcium stearate 1 ~ 3g, granulate, incapsulates, obtained Yuquan capsule 850.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Styrax: China's coastal port one ministerial standard.This product is that the balsam that the trunk of Hamamelidaceae Plants Styrax tree LiquidambarorientalisMill. oozes out forms through processing and refining.
Radix Et Rhizoma Nardostachyos: China's coastal port one ministerial standard.RADIXETRHIZOMANARDOSTACHYOS this product is the dry root and rhizome of Valerianaceae plant Radix Et Rhizoma Nardostachyos NardostachyschinensisBatal. or spoon Ye Gansong NardostachysjatamansiDC..Spring, Qiu Erji excavate, and removing silt and impurity, dry or dry in the shade.
Cortex Lycii: China's coastal port one ministerial standard.This product is the dry root bark of matrimony vine of solanaceae plant LyciumchinenseMill. or lycium barbarum LyciumbarbarumL..Excavate root at the beginning of spring or after autumn, clean, strip root bark, dry.
Radix Trichosanthis: China's coastal port one ministerial standard.This product is the dry root of cucurbitaceous plant Fructus Trichosanthis TrichosantheskirilowiiMaxim. or trichosanthes rosthornii Harms TrichosanthesrosthorniiHarms.Autumn, season in winter two excavate, and clean, removing crust, and cutting or vertical profile become lobe, dry.
Radix Ophiopogonis: China's coastal port one ministerial standard.This product is liliaceous plant Ophiopogonjaponicus(Thunb. Radix Ophiopogonis) dried root of Ker-Gawl..Summer excavates, and cleans, is repeatedly exposed to the sun, banks up. and to very likely in, removing fibrous root, dry.
Radix Ginseng: China's coastal port one ministerial standard.This product is the dry root and rhizome of Araliaceae Radix Ginseng PanaxginsengC.A.Mey..Excavate more than autumn, clean through drying or drying.Cultivation also known as " Park Ginseng "; Sowing under mountain forest wild state self-sow also known as " Panax Ginseng ", practise and claim " seed sea ".
Poria: China's coastal port one ministerial standard.This product is On Polyporaceae Poria Poriacocos(Schw.) dry sclerotia of Wolf.Excavate more than the 7-9 month, dig out rear removing silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now scatter and disappear in wrinkle, the large portion of internal moisture for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed different parts cutting, cloudy in, be called " Cortex Sclerotii Poriae " and " Poria block ".
Fructus Mume: China's coastal port one ministerial standard.This product is rose department plant plum Prunusmume(Sieb.) the dry almost ripe fruit of Sieb.etZucc..Summer gathers when fruit is closely ripe, vexed black to complexion changed after oven drying at low temperature.
The Radix Astragali: China's coastal port one ministerial standard.This product is leguminous plant Radix Astagali Astragalusmembranaceus(Fisch.) Bge.var.mongholicus(Bge.) Hsiao or Radix Astragali Astragalusmembranaceus(Fisch.) Bge, dry root.Spring, autumn two, Lee excavated, and removing fibrous root and root head, dry.
Radix Glycyrrhizae: China's coastal port one ministerial standard.This product is drying report and the rhizome of glycyrrhizic legume GlycyrrhizuralensisFisch., Glycyrrhiza inflata Bat. GlycyrrhizainflataBat. or Glycyrrhiza glabra L. Glycyrrhizagla-braL..Spring, long-pending to excavate in two seasons, removing fibrous root, dries.
Mannitol: Chinese Pharmacopoeia version two ministerial standard in 2010.
L MALIC ACID: Chinese Pharmacopoeia version two ministerial standard in 2010.
Crospolyvinylpyrrolidone: Chinese Pharmacopoeia version two ministerial standard in 2010.
Ethyl cellulose: Chinese Pharmacopoeia version two ministerial standard in 2010.
Carboxymethyl starch sodium: Chinese Pharmacopoeia version two ministerial standard in 2010.
Calcium stearate: Chinese Pharmacopoeia version two ministerial standard in 2010.
Raw material used by above Yuquan capsule all can be bought from pharmaceuticals and obtain, and all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Four detailed description of the invention
Specific embodiments of the invention 1
Get Styrax 144g, Radix Et Rhizoma Nardostachyos 288g, Cortex Lycii 22g, Radix Trichosanthis 200g, Radix Ophiopogonis 133g, Radix Ginseng 120g, Poria 144g, Fructus Mume 144g, Radix Astragali 133g, Radix Glycyrrhizae 144g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 16Mpa, extraction temperature 21 DEG C, separator pressure 13Mpa, separator temperature 41 DEG C, disengaging time 2.6 hours, carbon dioxide flow 25L per hour, obtains extracting solution; Get extracting solution 60 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, L MALIC ACID 45g, crospolyvinylpyrrolidone 45g, ethyl cellulose 35g, mix homogeneously, with 50% ethanol wet granulation, 60 DEG C of dryings, additional carboxymethyl starch sodium 7g, calcium stearate 1g, granulate, incapsulates, obtained Yuquan capsule 850.
Specific embodiments of the invention 2
Get Styrax 144g, Radix Et Rhizoma Nardostachyos 288g, Cortex Lycii 22g, Radix Trichosanthis 200g, Radix Ophiopogonis 133g, Radix Ginseng 120g, Poria 144g, Fructus Mume 144g, Radix Astragali 133g, Radix Glycyrrhizae 144g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 37Mpa, extraction temperature 43 DEG C, separator pressure 19Mpa, separator temperature 53 DEG C, disengaging time 3.5 hours, carbon dioxide flow 40L per hour, obtains extracting solution; Get extracting solution 80 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, L MALIC ACID 55g, crospolyvinylpyrrolidone 55g, ethyl cellulose 45g, mix homogeneously, with 70% ethanol wet granulation, 80 DEG C of dryings, additional carboxymethyl starch sodium 9g, calcium stearate 3g, granulate, incapsulates, obtained Yuquan capsule 850.
Specific embodiments of the invention 3
Get Styrax 144g, Radix Et Rhizoma Nardostachyos 288g, Cortex Lycii 22g, Radix Trichosanthis 200g, Radix Ophiopogonis 133g, Radix Ginseng 120g, Poria 144g, Fructus Mume 144g, Radix Astragali 133g, Radix Glycyrrhizae 144g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 27Mpa, extraction temperature 32 DEG C, separator pressure 16Mpa, separator temperature 47 DEG C, disengaging time 3.1 hours, carbon dioxide flow 33L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, L MALIC ACID 50g, crospolyvinylpyrrolidone 50g, ethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, calcium stearate 2g, granulate, incapsulates, obtained Yuquan capsule 850.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make Yuquan capsule.Actual effect of the present invention is investigated below with the Yuquan capsule that embodiment 3 is obtained:
(1) embodiment 3 Yuquan capsule and contrast disintegration of commercially available Yuquan capsule
1 disintegration time mensuration method
Measure by Chinese Pharmacopoeia version annex Ⅻ A in 2010.
Contrast 2 disintegrations
Table 1 embodiment 3 Yuquan capsule and commercially available Yuquan capsule contrast table disintegration
The above results shows, Yuquan capsule prepared by the present invention has the remarkable advantages such as disintegration rate is fast, bioavailability is high relative to commercially available Yuquan capsule.
(2) embodiment 3 Yuquan capsule and commercially available Yuquan capsule treatment deficiency of both vital energy and Yin, thirsty polydipsia, help digestion polyphagia; The above-mentioned patient clinical observation on the therapeutic effect of diabetes spp
1 case scenario
Statistics outpatient service and inpatient, observe deficiency of both vital energy and Yin altogether, thirsty polydipsia, help digestion polyphagia; Above-mentioned patient case 128 example of diabetes spp, 57 years old mean age.Patient is divided into two groups, test group takes embodiment 3 Yuquan capsule, and matched group takes commercially available Yuquan capsule.
2 efficacy assessment standards
According to new Chinese medicine treatment guideline of clinical investigations tcm syndrome curative effect determinate standard:
Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
Table 2 embodiment 3 Yuquan capsule and commercially available Yuquan capsule clinical efficacy contrast table
Above-mentioned clinical observation on the therapeutic effect result shows, Yuquan capsule prepared by the present invention is treating deficiency of both vital energy and Yin, thirsty polydipsia, and help digestion polyphagia; The above-mentioned patient of diabetes spp, evident in efficacy higher than commercially available Yuquan capsule, p < 0.05.
Claims (3)
1. treat a deficiency of both vital energy and Yin, thirsty polydipsia, help digestion polyphagia; The Chinese medicine of the above-mentioned patient of diabetes spp, it is characterized in that getting Styrax 144g, Radix Et Rhizoma Nardostachyos 288g, Cortex Lycii 22g, Radix Trichosanthis 200g, Radix Ophiopogonis 133g, Radix Ginseng 120g, Poria 144g, Fructus Mume 144g, Radix Astragali 133g, Radix Glycyrrhizae 144g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 16 ~ 37Mpa, extraction temperature 21 ~ 43 DEG C, separator pressure 13 ~ 19Mpa, separator temperature 41 ~ 53 DEG C, disengaging time 2.6 ~ 3.5 hours, carbon dioxide flow 25 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 ~ 80 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, L MALIC ACID 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, ethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, calcium stearate 1 ~ 3g, granulate, incapsulates, obtained Yuquan capsule.
2. the preparation method of Chinese medicine according to claim 1, it is characterized in that getting Styrax 144g, Radix Et Rhizoma Nardostachyos 288g, Cortex Lycii 22g, Radix Trichosanthis 200g, Radix Ophiopogonis 133g, Radix Ginseng 120g, Poria 144g, Fructus Mume 144g, Radix Astragali 133g, Radix Glycyrrhizae 144g, be ground into 60 order coarse powder, employing carbon dioxide supercritical extraction method is extracted, extracting pressure 16 ~ 37Mpa, extraction temperature 21 ~ 43 DEG C, separator pressure 13 ~ 19Mpa, separator temperature 41 ~ 53 DEG C, disengaging time 2.6 ~ 3.5 hours, carbon dioxide flow 25 ~ 40L per hour, obtains extracting solution; Get extracting solution 60 ~ 80 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 150 ~ 200g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, L MALIC ACID 45 ~ 55g, crospolyvinylpyrrolidone 45 ~ 55g, ethyl cellulose 35 ~ 45g, mix homogeneously, with 50 ~ 70% ethanol wet granulations, 60 DEG C ~ 80 DEG C dryings, additional carboxymethyl starch sodium 7 ~ 9g, calcium stearate 1 ~ 3g, granulate, incapsulates, obtained Yuquan capsule.
3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Styrax 144g, Radix Et Rhizoma Nardostachyos 288g, Cortex Lycii 22g, Radix Trichosanthis 200g, Radix Ophiopogonis 133g, Radix Ginseng 120g, Poria 144g, Fructus Mume 144g, Radix Astragali 133g, Radix Glycyrrhizae 144g, be ground into 60 order coarse powder, adopt carbon dioxide supercritical extraction method to extract, extracting pressure 27Mpa, extraction temperature 32 DEG C, separator pressure 16Mpa, separator temperature 47 DEG C, disengaging time 3.1 hours, carbon dioxide flow 33L per hour, obtains extracting solution; Get extracting solution 70 DEG C of drying under reduced pressure, get dry extract; Get dry cream and add mannitol 175g, adopt the impact grinding of high energy nanometer to be ground into the mixing dried cream powder of particle diameter 200 ~ 300nm; Get mixing dried cream powder, L MALIC ACID 50g, crospolyvinylpyrrolidone 50g, ethyl cellulose 40g, mix homogeneously, with 60% ethanol wet granulation, 70 DEG C of dryings, additional carboxymethyl starch sodium 8g, calcium stearate 2g, granulate, incapsulates, obtained Yuquan capsule.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510914183.2A CN105343509A (en) | 2015-12-13 | 2015-12-13 | Yuquan capsules and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510914183.2A CN105343509A (en) | 2015-12-13 | 2015-12-13 | Yuquan capsules and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN105343509A true CN105343509A (en) | 2016-02-24 |
Family
ID=55319667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510914183.2A Pending CN105343509A (en) | 2015-12-13 | 2015-12-13 | Yuquan capsules and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN105343509A (en) |
-
2015
- 2015-12-13 CN CN201510914183.2A patent/CN105343509A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN105343509A (en) | Yuquan capsules and preparation method thereof | |
CN105343336A (en) | Xiaotangling capsules and preparing method thereof | |
CN105343681A (en) | Cough-relieving exocarpium citri grandis capsules and preparation method thereof | |
CN105456700A (en) | Kidney-tonifying bone-supplementing capsule and preparation method thereof | |
CN104225359A (en) | Jiangtangjia tablet and preparation method thereof | |
CN105456763A (en) | Shenkangning capsules and preparation method thereof | |
CN104474384A (en) | Fuganning tablet and preparation method thereof | |
CN104383251A (en) | Koji capsule and preparation method thereof | |
CN105434977A (en) | Huoxiang Zhengqi capsule and preparation method thereof | |
CN104225046A (en) | Hyperostosis-resistant tablet and preparation method thereof | |
CN105497745A (en) | Liver-soothing tablets and preparation method thereof | |
CN105726923A (en) | Hypoglycemic capsule and preparation method thereof | |
CN105412748A (en) | Anti-tuberculosis capsules and preparation method thereof | |
CN105412598A (en) | Stomach-recovering capsule and preparation method thereof | |
CN104147348A (en) | Jiangtangning capsule and preparation method thereof | |
CN105326934A (en) | Pelvic inflammation eliminating capsule and preparation method thereof | |
CN105343573A (en) | Lung benefiting capsule and preparing method thereof | |
CN105412753A (en) | Stone removing capsule and preparation method thereof | |
CN104367904A (en) | Liver-soothing and melancholy-dispelling capsule and preparation method thereof | |
CN105343324A (en) | Weiyankang capsules and preparation method thereof | |
CN105412457A (en) | Capsule for treating hemialgia and preparation method thereof | |
CN105381203A (en) | Refraction-improving capsule and preparation method thereof | |
CN105327048A (en) | Pingfeng shengmai capsules and preparation method thereof | |
CN105708956A (en) | Fu Youning tablet and preparation method thereof | |
CN105412694A (en) | Anti-hunger and thirst-quenching tablet and preparation method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20160224 |
|
WD01 | Invention patent application deemed withdrawn after publication |