CN104399007A - Pancreas-clearing gallbladder-benefiting particle and preparation method thereof - Google Patents
Pancreas-clearing gallbladder-benefiting particle and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000002245 particle Substances 0.000 title abstract 5
- 239000000843 powder Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 241000218176 Corydalis Species 0.000 claims abstract description 10
- 229920001353 Dextrin Polymers 0.000 claims abstract description 9
- 239000004375 Dextrin Substances 0.000 claims abstract description 9
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 9
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 9
- 235000019425 dextrin Nutrition 0.000 claims abstract description 9
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000008101 lactose Substances 0.000 claims abstract description 9
- 208000007882 Gastritis Diseases 0.000 claims abstract description 6
- 206010033645 Pancreatitis Diseases 0.000 claims abstract description 6
- 206010033647 Pancreatitis acute Diseases 0.000 claims abstract description 6
- 201000003229 acute pancreatitis Diseases 0.000 claims abstract description 6
- 201000010099 disease Diseases 0.000 claims abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 6
- 239000008187 granular material Substances 0.000 claims description 31
- 239000000731 choleretic agent Substances 0.000 claims description 24
- 230000001989 choleretic effect Effects 0.000 claims description 24
- 210000000496 pancreas Anatomy 0.000 claims description 24
- 239000000284 extract Substances 0.000 claims description 21
- 238000001035 drying Methods 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 8
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 8
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 8
- 229940113124 polysorbate 60 Drugs 0.000 claims description 8
- 239000007921 spray Substances 0.000 claims description 8
- 206010013786 Dry skin Diseases 0.000 claims description 7
- 238000005550 wet granulation Methods 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 6
- 229910052623 talc Inorganic materials 0.000 claims description 4
- 235000012222 talc Nutrition 0.000 claims description 4
- 239000000454 talc Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 8
- 241000202726 Bupleurum Species 0.000 abstract description 2
- 244000163122 Curcuma domestica Species 0.000 abstract description 2
- 241000237502 Ostreidae Species 0.000 abstract description 2
- 244000292697 Polygonum aviculare Species 0.000 abstract description 2
- 235000006386 Polygonum aviculare Nutrition 0.000 abstract description 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000003392 Curcuma domestica Nutrition 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 241001165494 Rhodiola Species 0.000 abstract 1
- 235000003373 curcuma longa Nutrition 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 235000020636 oyster Nutrition 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 235000013976 turmeric Nutrition 0.000 abstract 1
- 239000000047 product Substances 0.000 description 8
- 208000011580 syndromic disease Diseases 0.000 description 5
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- YBMRDBCBODYGJE-UHFFFAOYSA-N germanium dioxide Chemical compound O=[Ge]=O YBMRDBCBODYGJE-UHFFFAOYSA-N 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 2
- 241000510654 Bupleurum chinense Species 0.000 description 1
- 241000208828 Caprifoliaceae Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000548230 Crassostrea angulata Species 0.000 description 1
- 241001522252 Crassostrea rivularis Species 0.000 description 1
- 241000220284 Crassulaceae Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 244000167230 Lonicera japonica Species 0.000 description 1
- 235000017617 Lonicera japonica Nutrition 0.000 description 1
- 241001523579 Ostrea Species 0.000 description 1
- 241000219061 Rheum Species 0.000 description 1
- 240000004980 Rheum officinale Species 0.000 description 1
- 241000997135 Rhodiola crenulata Species 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229940119177 germanium dioxide Drugs 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Marine Sciences & Fisheries (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pancreas-clearing gallbladder-benefiting particle and a preparation method thereof. The preparation method is characterized by comprising the following steps: crushing 118 g of rhodiola, 236 g of polygonum aviculare, 472 g of oyster, 472 g of turmeric, 283 g of honeysuckle, 189 g of bupleurum, 283 g of rhubarb and 283 g of corydalis tuber into coarse powder; placing the coarse powder in a cyclic ultrasonic extractor; adding water, germanium powder and tween-60, performing ultrasonic extracting, jetting, performing spray-drying to prepare nanometer extracting powder; adding lactose and dextrin to prepare the pancreas-clearing gallbladder-benefiting particle. The pancreas-clearing gallbladder-benefiting particles are used for treating the diseases, such as acute pancreatitis and acute gastritis; the treatment effect is superior to commercially available pancreas-clearing gallbladder-benefiting particles; a good effect is achieved.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of clear pancreas choleretic granules and preparation method thereof.
Background technology
The promoting QI circulation for relieving depression of clear pancreas choleretic granules, upper pain of invigorating blood circulation.'Shugan Lidan ', removing toxic substances relieving constipation.For acute pancreatitis, the diseases such as acute gastritis.Commercially available clear pancreas choleretic granules is due to prescription and technological reason, and curative effect is not satisfactory, and preparation adopts traditional handicraft preparation, there is the shortcoming that curative effect is low.
Summary of the invention
The present invention for overcoming above-mentioned deficiency, clear pancreas choleretic granules providing a kind of curative effect high and preparation method thereof.
Invention embodiment is as follows:
Get Radix Rhodiolae 118g ， Herba Polygoni Avicularis 236g, Concha Ostreae 472g, Rhizoma Curcumae Longae 472g, Flos Lonicerae 283g, Radix Bupleuri 189g, Radix Et Rhizoma Rhei 283g, Rhizoma Corydalis 283g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 23360g water, 6 ~ 8g germanium powder, 6 ~ 10g polysorbate60, select supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained clear pancreas choleretic granules.
The raw material standards that above-mentioned embodiment is mentioned is as follows:
Radix Rhodiolae: China's coastal port one ministerial standard.This product is crassulaceae plants Radix Rhodiolae Rhodiola crenulata(Hook f.et ThoMs.) the dry root and rhizome of H.Ohba.Autumn scape withered after excavate, removing rough bark, clean, dry.
Herba Polygoni Avicularis: China's coastal port one ministerial standard.This product is the dry aerial parts of Liao section Zhi Wu Herba Polygoni Avicularis Polygonum aviculare L..Gather during leafiness in summer, removing root and impurity, dry.
Concha Ostreae: China's coastal port one ministerial standard.This product is the shell of Ostreidae animal long Concha Ostreae Ostrea gigas Thunberg, Dalian Bay Concha Ostreae Ostrea talienwhanensis Crosse or Crassostrea rivularis Ostrear riv-ularis Gould.The whole year all can gather, fleshing, cleans, dries.
Rhizoma Curcumae Longae: China's coastal port one ministerial standard.This product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae Longae Curcuma longa L..Excavate when winter, stem and leaf was withered, clean, boil or steam to the saturating heart, drying, removing fibrous root.
Flos Lonicerae: China's coastal port one ministerial standard.This product is dry flower or the first flower opened of band of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb..Early summer the flowers are in blossom put before gather, dry.
Radix Bupleuri: China's coastal port one ministerial standard.This product is the dry root of umbelliferae bupleurum Bupleurum chinense DC. or Radix Bupeuri Scorzonerfolii. Bupleurum scocrzonerifolium Willd..Different by character, practise title " Radix Bupleuri " and " Radix Bupleuri Scorzonerifolii " respectively.Spring, Qiu Erji excavate, removing stem and leaf and silt, dry.
Radix Et Rhizoma Rhei: China's coastal port one ministerial standard.This product is a dry root and rhizome of section plant sorrel Rheum palmatum L. Rheum tanguticum Rheum tangicum Maxim.ex Balf. or Rheum officinale Rheumofficinale Baill..Autumn Mo in the stem and leaf withered or secondary spring excavates before germinateing. and removing is carefully reported, and to removing crust, valve cutting or section, rope wears bunchiness drying or convection drying.
Rhizoma Corydalis: China's coastal port one ministerial standard.This product is the dry tuber of papaveraceae plant corydalis Corydalis yanhusno W.T.Wang.Excavate when early summer stem and leaf is withered, removing fibrous root, cleans, and puts in boiling water and boils to during just without the white heart, take out, dry.
Germanium powder: germanium dioxide: No. CAS: 1310-53-8: industry standard: lark prestige Science and Technology Ltd.;
Polysorbate60: Chinese Pharmacopoeia version two ministerial standard in 2010;
Lactose: Chinese Pharmacopoeia version two ministerial standard in 2010;
Dextrin: Chinese Pharmacopoeia version two ministerial standard in 2010;
Pulvis Talci: Chinese Pharmacopoeia version one ministerial standard in 2010;
All can buy from pharmaceuticals with the raw material used by supernatant pancreas choleretic granules and obtain, be not limited to typical production producer, all can be used to implement the present invention program as long as meet quality standard.
The key equipment that foregoing invention embodiment is mentioned is as follows:
Circulating ultrasonic machine: supersonic frequency 20 ~ 100KHz,
(typical production producer: Beijing Hongxianglong Biotechnology Development Co., Ltd)
Jet spray dryer: inlet temperature scope 30 ~ 70 DEG C, 300 ~ 900 meters per second of effluxvelocity scope;
(typical production producer: Nai Nuo bio tech ltd, Beijing)
All can buy from pharmaceuticals with the raw material used by supernatant pancreas choleretic granules and obtain, all can be used to implement the present invention program as long as meet national standard.
In foregoing invention scheme, term used is pharmacy proprietary term, as " decompression " etc. all defers to Chinese Pharmacopoeia regulation and pharmaceutical practice of being correlated with.
Unit g in the present invention also can be other weight portion, does not affect the enforcement of the present invention program.
Equipment Market described in the present invention program all has sale, is not limited to typical production producer, as long as technical specification can reach requirement, all can be used to realize the present invention.
Detailed description of the invention
Specific embodiments of the invention 1
Get Radix Rhodiolae 118g ， Herba Polygoni Avicularis 236g, Concha Ostreae 472g, Rhizoma Curcumae Longae 472g, Flos Lonicerae 283g, Radix Bupleuri 189g, Radix Et Rhizoma Rhei 283g, Rhizoma Corydalis 283g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 23360g water, 6g germanium powder, 6g polysorbate60, select supersonic frequency 50KHz, pressure 0.3Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 DEG C, pressure 0.02Mpa, 400 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 25g, mixing, obtained clear pancreas choleretic granules.
Specific embodiments of the invention 2
Get Radix Rhodiolae 118g ， Herba Polygoni Avicularis 236g, Concha Ostreae 472g, Rhizoma Curcumae Longae 472g, Flos Lonicerae 283g, Radix Bupleuri 189g, Radix Et Rhizoma Rhei 283g, Rhizoma Corydalis 283g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 23360g water, 8g germanium powder, 10g polysorbate60, select supersonic frequency 60KHz, pressure 0.5 Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 50 DEG C, pressure 0.04 Mpa, 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 25g, mixing, obtained clear pancreas choleretic granules.
Specific embodiments of the invention 3
Get Radix Rhodiolae 118g ， Herba Polygoni Avicularis 236g, Concha Ostreae 472g, Rhizoma Curcumae Longae 472g, Flos Lonicerae 283g, Radix Bupleuri 189g, Radix Et Rhizoma Rhei 283g, Rhizoma Corydalis 283g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 23360g water, 7g germanium powder, 8g polysorbate60, select supersonic frequency 55KHz, pressure 0.4Mpa extracts 30 minutes, use 80 mesh screen, obtain extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 45 DEG C, pressure 0.03Mpa, 500 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Pulvis Talci 25g, mixing, obtained clear pancreas choleretic granules.
Above embodiment illustrates, adopts the extreme condition of embodiment of the present invention and optimal conditions all can make pancreas choleretic granules clearly.Actual effect of the present invention is investigated below with the clear pancreas choleretic granules that embodiment 3 is obtained:
(1) the clear pancreas choleretic granules of embodiment 3 and commercially available clear pancreas choleretic granules treat acute pancreatitis, the Disease Clinical observation of curative effect such as acute gastritis
1 case scenario
The disease cases 104 such as statistics outpatient service and inpatient, observe acute pancreatitis altogether, acute gastritis example, 44 years old mean age.Patient is divided into two groups, test group takes the clear pancreas choleretic granules of embodiment 3, and matched group takes the clear pancreas choleretic granules of tradition.
2 efficacy assessment standards
According to new Chinese medicine guideline of clinical investigations tcm syndrome curative effect determinate standard:
Cure: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.
Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
Invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces < 30%.
Computing formula: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
3 clinical observation result
The clear pancreas choleretic granules of table 1 embodiment 3 and commercially available clear pancreas choleretic granules clinical efficacy contrast
Above-mentioned clinical observation on the therapeutic effect result shows, clear pancreas choleretic granules prepared by the present invention is at treatment acute pancreatitis, during the diseases such as acute gastritis, evident in efficacy higher than commercially available clear pancreas choleretic granules, p < 0.05.
Claims (3)
1. treat an acute pancreatitis, the Chinese medicine of the diseases such as acute gastritis, is characterized in that getting Radix Rhodiolae 118g, Herba Polygoni Avicularis 236g, Concha Ostreae 472g, Rhizoma Curcumae Longae 472g, Flos Lonicerae 283g, Radix Bupleuri 189g, Radix Et Rhizoma Rhei 283g, Rhizoma Corydalis 283g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 23360g water, 6 ~ 8g germanium powder, 6 ~ 10g polysorbate60, selects supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained clear pancreas choleretic granules.
2. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Radix Rhodiolae 118g ， Herba Polygoni Avicularis 236g, Concha Ostreae 472g, Rhizoma Curcumae Longae 472g, Flos Lonicerae 283g, Radix Bupleuri 189g, Radix Et Rhizoma Rhei 283g, Rhizoma Corydalis 283g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 23360g water, 6 ~ 8g germanium powder, 6 ~ 10g polysorbate60, selects supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained clear pancreas choleretic granules.
3. the preparation method of Chinese medicine according to claim 1, is characterized in that getting Radix Rhodiolae 118g ， Herba Polygoni Avicularis 236g, Concha Ostreae 472g, Rhizoma Curcumae Longae 472g, Flos Lonicerae 283g, Radix Bupleuri 189g, Radix Et Rhizoma Rhei 283g, Rhizoma Corydalis 283g, be ground into 40 order coarse powder, put in circulating ultrasonic extractor, add 23360g water, 6 ~ 8g germanium powder, 6 ~ 10g polysorbate60, selects supersonic frequency 50 ~ 60KHz, pressure 0.3 ~ 0.5 Mpa extracts 30 minutes, uses 80 mesh screen, obtains extracting solution; Getting extracting solution puts in jet spray dryer, and control inlet temperature 40 ~ 50 DEG C, pressure 0.02 ~ 0.04 Mpa, 400 ~ 600 meters per second of flow velocity, obtains nanometer extract powder; Get extract powder and add lactose 400g, dextrin 100g, use water wet granulation, 60 DEG C of dryings, granulate, adds Talcum 25g, mixing, obtained clear pancreas choleretic granules.
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|---|---|---|---|
| CN201410760759.XA CN104399007A (en) | 2014-12-12 | 2014-12-12 | Pancreas-clearing gallbladder-benefiting particle and preparation method thereof |
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| CN201410760759.XA CN104399007A (en) | 2014-12-12 | 2014-12-12 | Pancreas-clearing gallbladder-benefiting particle and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108362790A (en) * | 2018-01-26 | 2018-08-03 | 吉林修正药业新药开发有限公司 | A kind of construction method of Chinese patent drug " clear pancreas choleretic granules " HPLC characteristic spectrums |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108362790A (en) * | 2018-01-26 | 2018-08-03 | 吉林修正药业新药开发有限公司 | A kind of construction method of Chinese patent drug " clear pancreas choleretic granules " HPLC characteristic spectrums |
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Application publication date: 20150311 |