CN106215126A - FUFANG BANMAO JIAONANG and preparation method thereof - Google Patents
FUFANG BANMAO JIAONANG and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a kind of FUFANG BANMAO JIAONANG and preparation method thereof, described FUFANG BANMAO JIAONANG includes that the raw material of following weight parts is prepared from: Mylabris, Radix Ginseng, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Sparganii, Herba Scutellariae Barbatae, Rhizoma Curcumae, Fructus Corni, Fructus Ligustri Lucidi, Fel Ursi powder, Radix Glycyrrhizae.FUFANG BANMAO JIAONANG of the present invention, has removing blood stasis and disappears silt, effect of counteracting toxic substances phagedenoma, be natural Chinese medicines product, its preparation method can fully extract oil-soluble and aqueous soluble active constituent, improves the bioavailability of medical material, adds adjuvant simultaneously, ensure that the steady quality of medicine, promote drug quality.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of FUFANG BANMAO JIAONANG and preparation method thereof.
Background technology
FUFANG BANMAO JIAONANG is clinical conventional Chinese patent medicine, its be mainly composed of Mylabris, Rhizoma Curcumae, Rhizoma Sparganii, the Radix Astragali, Radix Ginseng,
Fructus Ligustri Lucidi, Fructus Corni, Radix Et Caulis Acanthopanacis Senticosi, Fel Ursi powder, Herba Scutellariae Barbatae, Radix Glycyrrhizae.Mylabris in side, counteracting toxic substances phagedenoma, removing blood stasis eliminating stagnation, for monarch drug.Three
Rib, Rhizoma Curcumae are ministerial drug altogether, to strengthen monarch drug blood circulation invigorating efficacies.The two, with entering liver spleen channel, can enter blood system with removing blood stasis blood stasis removing, again
Edema caused by disorder of QI can be walked with circulation of qi promoting removing food stagnancy, for the key medicine of middle stagnation of QI in lower-JIAO blood stasis, can be used for treating the cards such as lump in the abdomen.Radix Ginseng, yellow late-maturing, thorn
Slender acanthopanax strengthening spleen, tonifying kidney, benefiting vital QI and blood.Fructus Corni, Fructus Ligustri Lucidi nourishing the liver and kidney, yin nourishing spermatogenesis.Five medicines share, eliminating evil and just do not hinder, and
Can prevent ecchymosis from spreading.Herba Scutellariae Barbatae, Fel Ursi powder assistant principal drug assistance counteracting toxic substances phagedenoma, be adjuvant drug altogether, energy heat-clearing and toxic substances removing, blood stasis dispelling diuresis.Sweet
Grass coordinating the actions of various ingredients in a prescription, for making medicine.All medicines share, and play removing blood stasis altogether and disappear, the merit of counteracting toxic substances phagedenoma.
Modern pharmacology research confirms, FUFANG BANMAO JIAONANG has obvious adjunct antineoplastic effect, can be by strengthening machine
Body immunity and direct killing tumor cell and play its antitumaous effect, FUFANG BANMAO JIAONANG has the blocking-up cancer cell division cycle
The M phase, promote apoptosis of tumor cells, destroy cancerous cell, cytoskeleton and ultrastructure, suppression tumor-blood-vessel growth, promotion tumor
The respiration inhibition rate of cell and the activity of lysosomal enzyme;Meanwhile, it has stimulation myelosis, the synthesis of medullary cell DNA,
Thus there is effect of leukocyte increasing;In recent years, FUFANG BANMAO JIAONANG is at nasopharyngeal carcinoma, pulmonary carcinoma, esophagus to have multinomial research to find
Potentiation is played in the radiotherapy such as cancer, laryngeal carcinoma, is a kind of effective Chinese medicine radiotherapy hypersitization medicine, its be treatment primary hepatocarcinoma,
One of preferable medicine of pulmonary carcinoma, rectal cancer, malignant lymphoma, gynecologic malignant tumor etc..
Summary of the invention
One of the technical problem to be solved is to provide a kind of FUFANG BANMAO JIAONANG.
Solve the technical problem that the two of the present invention are to provide the preparation method of a kind of FUFANG BANMAO JIAONANG.
The present invention seeks to be achieved through the following technical solutions:
A kind of FUFANG BANMAO JIAONANG, the raw material including following weight parts is prepared from: Mylabris, Radix Ginseng, the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi,
Rhizoma Sparganii, Herba Scutellariae Barbatae, Rhizoma Curcumae, Fructus Corni, Fructus Ligustri Lucidi, Fel Ursi powder, Radix Glycyrrhizae.
A kind of FUFANG BANMAO JIAONANG, it is characterised in that be prepared from by the raw material of following weight parts: raw material of Chinese medicine Mylabris 1-
5 parts, Radix Ginseng 3-15 part, Radix Astragali 8-80 part, Radix Et Caulis Acanthopanacis Senticosi 8-80 part, Rhizoma Sparganii 4-20 part, Herba Scutellariae Barbatae 15-80 part, Rhizoma Curcumae 3-25 part, mountain
Fructus Evodiae 4-28 part, Fructus Ligustri Lucidi 4-28 part, Fel Ursi powder 0.05-0.09 part, Radix Glycyrrhizae 2-10 part, adjuvant 0.05-1.5 part.
Preferably, described adjuvant is that one or more in maltose alcohol, citronellol, phytic acid mix.
It is highly preferred that described adjuvant is mixed by maltose alcohol, citronellol, phytic acid, described maltose alcohol,
Citronellol, the mass ratio of phytic acid are (1-3): (1-3): (1-3).
The preparation method of a kind of FUFANG BANMAO JIAONANG, comprises the following steps:
(1) being pulverized by Radix Ginseng is 100-150 mesh, sieves for subsequent use;
(2) by the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Sparganii, Herba Scutellariae Barbatae, Rhizoma Curcumae, Fructus Corni, Fructus Ligustri Lucidi, Radix Glycyrrhizae eight taste, pulverize as 60-100
Mesh, sieves, mix homogeneously, carries out carbon dioxide supercritical fluid extraction, extraction time 1.5-3.5 hour, extraction temperature 35-55 DEG C,
Extracting pressure 20-40MPa, adds entrainer in extraction process, the flow of entrainer is 0.5-1.5kg/h, the stream of carbon dioxide
Amount is 10-20kg/h, obtains extraction medicinal liquid, filters, and filtrate reduced in volume to density is the extraction clear paste (I) of 1.15-1.25g/mL;
(3) medicinal residues of step (2) add the water of medical material amount 8-12 times, decocts 1-2 hour, filtered while hot, collect filter
Liquid;The clear water adding 6-10 times of medication amount in medicinal residues decocts 0.5-1.5 hour, filters waste;Merge twice filtrate, decompression
It is concentrated into the water that density is 1.15-1.25g/mL and carries clear paste (II);
(4) weigh Mylabris, pulverize as 60-100 mesh, sieve, with water retting 1-3 hour of 8-12 times amount, then decoct 2 little
Time, filtered while hot, collect filtrate;Medicinal residues add the soak by water 1 hour of 6-10 times amount, filters waste;Merge twice filter
Liquid, is evaporated to the clear paste (III) that density is 1.15-1.25g/mL;
(5) weigh Fel Ursi powder, with the 65-85 DEG C of water dissolution of 4-6 times, add clear paste I, II, III, Radix Ginseng fine powder and adjuvant,
Mixing, pelletizes, and dry, pulverize as 100-150 mesh fine powder, encapsulated, to obtain final product.
Preferably, the entrainer of described step (2) is that one or more in ethanol, petroleum ether, acetone mix.
It is highly preferred that the entrainer of described step (2) is mixed by ethanol, petroleum ether, acetone, described ethanol, oil
Mass ratio in ether, acetone is (1-3): (1-3): (1-3).
Concrete, in the present invention:
Mylabris, is Meloidae insecticide Mylabris phalarata (Mylabris phalerata Pallas) or (M.cichorii
Linnaeus) dry body of yellow black mylabris cichorii.Nature and flavor: pungent, heat;Very toxic.Gui Jing: return liver, stomach, kidney channel.Effect: removing blood stasis disappears
, counteracting toxic substances phagedenoma, draw red foaming.
Curing mainly: for abdominal mass lump, stubborn dermatitis for many years, scrofula, wart, carbuncle is not burst, the dead flesh of malignant boil.
Radix Ginseng, Classification system: PanaxginsengC.A.Mey., nature and flavor: hardship sweet, micro-are flat.Gui Jing: return spleen, lung, heart channel.
Effect: strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, calms the nerves.Cure mainly: for weak body and prostration, cold extremities faint pulse, insufficiency of the spleen food
Few, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness void is won, and palpitation with fear insomnia, sun layer official is cold;Heart failure, cardiogenic shock.
The Radix Astragali, Classification system: Leguminosae, nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, profit
Urine poison holding, evacuation of pus, expelling pus and promoting granulation.Cure mainly: weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, table
Empty spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and bursts for a long time and does not holds back, and blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst;Chronic nephritis proteinuria, diabetes.
Radix Et Caulis Acanthopanacis Senticosi, Classification system: Acanthopanax senticosus, nature and flavor: hardship pungent, micro-, temperature.Gui Jing: return spleen, kidney,
Heart channel.Effect: replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.Cure mainly: for deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia
Dreaminess..
Rhizoma Sparganii, for Sparganiaceae plant rhizoma scirpi (Sparganium stoloniferum (Graebn.) Buch.-
Ham.ex Juz.) dry tuber, nature and flavor: pungent, bitter, flat.Gui Jing: return liver, spleen channel.Effect: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Main
Control: for trace mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.
Herba Scutellariae Barbatae, Classification system: Scutellaria barbata D.Don, nature and flavor: pungent, bitter, cold.Gui Jing: return lung, liver,
Kidney channel.Effect: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.Cure mainly: for furuncle swelling toxin, laryngopharynx swelling and pain, venom, fall and flutter the pain of injury, water
Swollen, jaundice..
Rhizoma Curcumae, Classification system: Curcuma zedoaria (Christm.) Rosc, nature and flavor: pungent, bitter, temperature.Gui Jing: return liver,
Spleen channel.Effect: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.Cure mainly: for abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain;Early cervical carcinoma.
Fructus Corni, Classification system: Cornusofficinalis, nature and flavor: sour, puckery, tepor.Gui Jing: return liver, kidney channel.Merit
Effect: liver and kidney tonifying, essence astringing and desertion stemming.Curing mainly: for vertigo and tinnitus. soreness of waist and knee joint, sun is passed out semen repeatly.Enuresis frequent micturition. bleeding not during menses. big
Antiperspirant is collapsed. and interior-heat is quenched one's thirst.
Fructus Ligustri Lucidi, Classification system: Ligustrum lucidum Ait, nature and flavor: sweet, bitter, cold.Gui Jing: return liver, kidney channel.Merit
Effect: nourishing liver, kidney, improving eyesight black hair.Cure mainly: for vertigo and tinnitus. soreness of the waist and knees, early whitening of beard and hair, poor vision.
Fel Ursi powder, for powder, irregular fragment or granule, brown color, green-yellow or dark-brown, translucent, there is hyaloid
Gloss.Matter is crisp, the easy moisture absorption, the micro-raw meat of gas delicate fragrance, the most bitter micro-Hui Tian of taste, has refrigerant sense.Country's ministry standard regulation, main in Fel Ursi powder
Want active ingredient tauroursodeoxycholic acid content must not be less than 23%.Cold in nature, nontoxic, bitter in the mouth Hui Tian, the micro-raw meat of gas delicate fragrance.Fel Ursi powder
There is stronger pain relieving spasmolytic effect, gram positive bacteria is had stronger inhibitory action.It is suitable for traumatic injury stagnated fire excess-heat
Various pain, treat children's;Cool breeze, conjunctivitis, furuncle hemorrhoid malignant boil etc..Can also promote that sugar and lactic acid synthesize glycogen source, strengthen pancreas
The effect of island element and secretion, thus there is reduction blood glucose and the effect of glucose in urine.
Radix Glycyrrhizae, Classification system: Glycyrrhiza uralensis Fisch., nature and flavor: sweet are flat.Gui Jing: GUIXIN.Lung,
Spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cure mainly: for weakness of the spleen and stomach,
Fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, institute's abdomen, extremity contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Maltose alcohol, No. CAS: 585-88-6.
Citronellol, No. CAS: 106-22-9.
Phytic acid, No. CAS: 83-86-3.
Ethanol, No. CAS: 64-17-5.
Petroleum ether, No. CAS: 8032-32-4.
Acetone, No. CAS: 67-64-1.
FUFANG BANMAO JIAONANG of the present invention, has removing blood stasis and disappears silt, effect of counteracting toxic substances phagedenoma, be natural Chinese medicines product, its system
Preparation Method can fully extract oil-soluble and aqueous soluble active constituent, improves the bioavailability of medical material, adds adjuvant simultaneously,
Ensure that the steady quality of medicine, promote drug quality.
Detailed description of the invention
Embodiment 1
FUFANG BANMAO JIAONANG raw material (weight portion): raw material of Chinese medicine Mylabris 3 parts, Radix Ginseng 8 parts, the Radix Astragali 50 parts, Radix Et Caulis Acanthopanacis Senticosi 50 parts,
Rhizoma Sparganii 12 parts, Herba Scutellariae Barbatae 50 parts, Rhizoma Curcumae 15 parts, Fructus Corni 18 parts, Fructus Ligustri Lucidi 18 parts, Fel Ursi powder 0.06 part, 6 parts of Radix Glycyrrhizae, adjuvant
0.09 part.
The preparation method of FUFANG BANMAO JIAONANG, comprises the following steps:
(1) being pulverized by Radix Ginseng is 120 mesh, sieves for subsequent use;
(2) by the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Sparganii, Herba Scutellariae Barbatae, Rhizoma Curcumae, Fructus Corni, Fructus Ligustri Lucidi, Radix Glycyrrhizae eight taste, pulverizing is 80 mesh,
Sieve, mix homogeneously, carry out carbon dioxide supercritical fluid extraction, extraction time 2 hours, extraction temperature 45 DEG C, extracting pressure
30MPa, adds entrainer in extraction process, the flow of entrainer is 0.9kg/h, and the flow of carbon dioxide is 15kg/h, obtains extraction
Taking liquid, uses 300 mesh filter-cloth filterings, and filtrate reduced in volume to density is the extraction clear paste (I) of 1.20g/mL (50 DEG C);
(3) medicinal residues of step (2) add the water of medicinal residues weight 10 times, decocts 1.5 hours, use 300 mesh filters while hot
Cloth filters, and collects filtrate;Medicinal residues add the soak by water 1 hour of medicinal residues weight 8 times, uses 300 mesh filter-cloth filtering wastes;
Merge twice filtrate, be evaporated to the water that density is 1.20g/mL (50 DEG C) and carry clear paste (II);
(4) weighing Mylabris, pulverizing is 80 mesh, sieves, with the water retting 2 hours of Mylabris weight 10 times, then decoct 2 little
Time, use 300 mesh filter-cloth filterings while hot, collect filtrate;Medicinal residues add the soak by water 1 hour of Mylabris weight 8 times, uses
300 mesh filter-cloth filtering wastes;Merge twice filtrate, be evaporated to the clear paste (III) that density is 1.20g/mL (50 DEG C);
(5) weigh Fel Ursi powder, with 80 DEG C of water dissolutioies of Fel Ursi powder weight 5 times, add clear paste I, clear paste II, clear paste III, people
Ginseng fine powder and adjuvant, mixing, pelletize, dry, pulverize is 120 mesh fine powders, encapsulated, to obtain final product.
Described adjuvant is mixed by maltose alcohol, citronellol, phytic acid, described maltose alcohol, citronellol, flesh
The mass ratio of alcohol six phosphoric acid is 1:1:1.
The entrainer of described step (2) is mixed by ethanol, petroleum ether, acetone, in described ethanol, petroleum ether, acetone
Mass ratio be 1:1:1.
Embodiment 2
Substantially the same manner as Example 1, differ only in: described adjuvant is 1:1 in mass ratio by maltose alcohol, citronellol
Mix homogeneously obtains.Obtain the FUFANG BANMAO JIAONANG of embodiment 2.
Embodiment 3
Substantially the same manner as Example 1, differ only in: described adjuvant is by maltose alcohol, phytic acid in mass ratio
Obtain for 1:1 mix homogeneously.Obtain the FUFANG BANMAO JIAONANG of embodiment 3.
Embodiment 4
Substantially the same manner as Example 1, differ only in: described adjuvant by citronellol, phytic acid is in mass ratio
1:1 mix homogeneously obtains.Obtain the FUFANG BANMAO JIAONANG of embodiment 4.
Embodiment 5
Substantially the same manner as Example 1, differ only in: the entrainer of described step (2) by ethanol, petroleum ether by quality
Ratio obtains for 1:1 mix homogeneously.Obtain the FUFANG BANMAO JIAONANG of embodiment 5.
Embodiment 6
Substantially the same manner as Example 1, differ only in: the entrainer of described step (2) is by ethanol, acetone in mass ratio
Obtain for 1:1 mix homogeneously.Obtain the FUFANG BANMAO JIAONANG of embodiment 6.
Embodiment 7
Substantially the same manner as Example 1, differ only in: the entrainer of described step (2) by petroleum ether, acetone by quality
Ratio obtains for 1:1 mix homogeneously.Obtain the FUFANG BANMAO JIAONANG of embodiment 7.
Test case 1
Containing cantharidin in FUFANG BANMAO JIAONANG of the present invention, cantharidin is the effective ingredient of Mylabris, therefore by its main component
Cantharidin is set to one of index components of FUFANG BANMAO JIAONANG assay.The FUFANG BANMAO JIAONANG of testing example 1-7 respectively
The content of middle cantharidin, with reference to Qin Liuzhen, " in high effective liquid chromatography for measuring FUFANG BANMAO JIAONANG, cantharidin contains method of testing
Amount ", concrete outcome is shown in Table 1.
Table 1: cantharidin content measuring list position: mg/g
Comparing embodiment 1 and embodiment 2-4, embodiment 1 (maltose alcohol, citronellol, phytic acid are compounding) ferulic acid
Content is apparently higher than embodiment 2-4 (maltose alcohol, citronellol, phytic acid arbitrarily the two compounding).Comparing embodiment 1 is with real
Execute example 5-7, embodiment 1 (ethanol, petroleum ether, acetone are compounding) ferulaic acid content apparently higher than embodiment 5-7 (ethanol, petroleum ether,
Arbitrarily the two compounds acetone).
Test case 2
FUFANG BANMAO JIAONANG embodiment 1-7 prepared, is placed in 25 DEG C, preservation half a year under relative humidity 85% environment, so
After carry out the test of escherichia coli (ATYCC 25922) total plate count, with reference to " GBT 4789.2-2008 food hygiene microbiology
Inspection total plate count measures ".Concrete test result is shown in Table 2.
Table 2: total plate count test table cfu/g
E. coli clones sum | |
Embodiment 1 | 208 |
Embodiment 2 | 423 |
Embodiment 3 | 417 |
Embodiment 4 | 435 |
Embodiment 5 | 459 |
Embodiment 6 | 532 |
Embodiment 7 | 468 |
Comparing embodiment 1 and embodiment 2-4, embodiment 1 (maltose alcohol, citronellol, phytic acid are compounding) anti-corrosive properties
Embodiment 2-4 (arbitrarily the two compounds for maltose alcohol, citronellol, phytic acid) can be substantially better than.Comparing embodiment 1 and enforcement
Example 5-7, embodiment 1 (ethanol, petroleum ether, acetone are compounding) antiseptic property is substantially better than embodiment 5-7 (ethanol, petroleum ether, acetone
Arbitrarily the two compounds).
Claims (7)
1. a FUFANG BANMAO JIAONANG, it is characterised in that include that the raw material of following weight parts is prepared from: Mylabris, Radix Ginseng, Huang
Stilbene, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Sparganii, Herba Scutellariae Barbatae, Rhizoma Curcumae, Fructus Corni, Fructus Ligustri Lucidi, Fel Ursi powder, Radix Glycyrrhizae.
2. a FUFANG BANMAO JIAONANG, it is characterised in that be prepared from by the raw material of following weight parts: raw material of Chinese medicine Mylabris 1-5
Part, Radix Ginseng 3-15 part, Radix Astragali 8-80 part, Radix Et Caulis Acanthopanacis Senticosi 8-80 part, Rhizoma Sparganii 4-20 part, Herba Scutellariae Barbatae 15-80 part, Rhizoma Curcumae 3-25 part, mountain
Fructus Evodiae 4-28 part, Fructus Ligustri Lucidi 4-28 part, Fel Ursi powder 0.05-0.09 part, Radix Glycyrrhizae 2-10 part, adjuvant 0.05-1.5 part.
3. the preparation method of FUFANG BANMAO JIAONANG as claimed in claim 2, it is characterised in that: described adjuvant is maltose
One or more in alcohol, citronellol, phytic acid mix.
4. the preparation method of FUFANG BANMAO JIAONANG as claimed in claim 3, it is characterised in that: described adjuvant is by maltose
Alcohol, citronellol, phytic acid mix, and described maltose alcohol, citronellol, the mass ratio of phytic acid are (1-3):
(1-3): (1-3).
5. the preparation method of the FUFANG BANMAO JIAONANG as according to any one of claim 1-4, it is characterised in that include following step
Rapid:
(1) being pulverized by Radix Ginseng is 100-150 mesh, sieves for subsequent use;
(2) by the Radix Astragali, Radix Et Caulis Acanthopanacis Senticosi, Rhizoma Sparganii, Herba Scutellariae Barbatae, Rhizoma Curcumae, Fructus Corni, Fructus Ligustri Lucidi, Radix Glycyrrhizae eight taste, pulverize as 60-100 mesh,
Sieve, mix homogeneously, carry out carbon dioxide supercritical fluid extraction, extraction time 1.5-3.5 hour, extraction temperature 35-55 DEG C, extraction
Pressure 20-40MPa, adds entrainer in extraction process, the flow of entrainer is 0.5-1.5kg/h, and the flow of carbon dioxide is
10-20kg/h, obtains extraction medicinal liquid, filters, and filtrate reduced in volume to density is the extraction clear paste (I) of 1.15-1.25g/mL;
(3) medicinal residues of step (2) add the water of medical material amount 8-12 times, decocts 1-2 hour, filtered while hot, collect filtrate;Medicine
The clear water adding 6-10 times of medication amount in slag decocts 0.5-1.5 hour, filters waste;Merge twice filtrate, concentrating under reduced pressure
Clear paste (II) is carried to the water that density is 1.15-1.25g/mL;
(4) weigh Mylabris, pulverize as 60-100 mesh, sieve, with water retting 1-3 hour of 8-12 times amount, then decoct 2 hours,
Filtered while hot, collects filtrate;Medicinal residues add the soak by water 1 hour of 6-10 times amount, filters waste;Merge twice filtrate,
It is evaporated to the clear paste (III) that density is 1.15-1.25g/mL;
(5) weigh Fel Ursi powder, with the 65-85 DEG C of water dissolution of 4-6 times, add clear paste I, II, III, Radix Ginseng fine powder and adjuvant, mixing,
Pelletize, dry, pulverize as 100-150 mesh fine powder, encapsulated, to obtain final product.
6. the preparation method of FUFANG BANMAO JIAONANG as claimed in claim 5, it is characterised in that: the entrainer of described step (2)
Mix for one or more in ethanol, petroleum ether, acetone.
7. the preparation method of FUFANG BANMAO JIAONANG as claimed in claim 6, it is characterised in that: the entrainer of described step (2)
Being mixed by ethanol, petroleum ether, acetone, the mass ratio in described ethanol, petroleum ether, acetone is (1-3): (1-3): (1-3).
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CN105816760A (en) * | 2016-03-18 | 2016-08-03 | 陈治斌 | Plaster capable of activating blood circulation to dissipate blood stasis, relieving pain, stopping bleeding, healing sore, promoting tissue regeneration, and eliminating inflammation and preparation method thereof |
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2016
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CN105816760A (en) * | 2016-03-18 | 2016-08-03 | 陈治斌 | Plaster capable of activating blood circulation to dissipate blood stasis, relieving pain, stopping bleeding, healing sore, promoting tissue regeneration, and eliminating inflammation and preparation method thereof |
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