CN105998099A - Cordyceps sinensis buccal tablet and preparation method thereof - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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Abstract
The invention discloses a Cordyceps sinensis buccal tablet, including the following components according to parts by weight: 100 parts of Cordyceps sinensis powder, 150-300 parts of Herba Cynomorii powder, 100-150 parts of maltodextrin, 50-100 parts of starch and 100-150 parts of xylitol. The invention also discloses a preparation method for preparing the above-mentioned Cordyceps sinensis buccal tablet, including the following steps: 1), powdering: crushing Cordyceps sinensis having water content (weight) of greater than or equal to 15% at a temperature less than or equal to 0 DEG C; crushing Herba Cynomorii having water content (weight) of greater than or equal to 20% at a temperature less than or equal to 0 DEG C; 2), burdening: mixing well the components of the Cordyceps sinensis buccal tablet according to parts by weight to obtain Cordyceps sinensis mixed powder; 3), rehydrating: ultrasonically atomizing rehydrating water into mist, and charging the mist into the Cordyceps sinensis mixed powder; stirring the Cordyceps sinensis mixed powder so that its water content (weight) uniformly rises to 4-20% to obtain Cordyceps sinensis rehydrated powder having water content (weight) of 4-20%; 4), tableting the obtained Cordyceps sinensis rehydrated powder to obtain the Cordyceps sinensis buccal tablet.
Description
Technical field
The invention belongs to Cordyceps deep process technology field, be specifically related to a kind of Cordyceps sinensis buccal tablets and preparation method thereof.
Background technology
Cordyceps has another name called Cordyceps, is China's famous and precious tonic herb of usual one among the people, and its nutritional labeling is higher than Radix Ginseng,
Can be used as medicine, it is possible to edible, be superior delicacies, there is the highest nutritive value.Cordyceps can with the immunity of enhancing body,
Nourishing lung and kidney, has obvious inhibitory action to pulmonary carcinoma, hepatocarcinoma etc..Clinically to chronic cough of deficiency lung, asthma, hemoptysis of pulmonary tuberculosis, steal
Red blood cell decreased after antiperspirant, soreness of waist and knee joint of suffering from a deficiency of the kidney, impotence and seminal emission, neurasthenia and chemotherapy, radiotherapy is the most effective in cure.
Cordyceps sinensis buccal tablets is a kind of abundant cordycepin, Cordyceps polysaccharide, cordycepic acid and the super oxidation extracted from Cordyceps
The health promoting product of the medicinal health care function such as thing dismutase.When being heated beyond 60 DEG C because of Cordyceps, essential ingredient such as polysaccharide, volatilization
Property material etc. can be destroyed, and causes the proportion of composing of Cordyceps essential ingredient to change, it is impossible to synergism and substantially reduce it
Medicinal efficacy, the acid DNase of 15 minutes its antitumor actions having of 80 DEG C of heating will thoroughly inactivate, and
The appearance of Cordyceps sinensis buccal tablets allows absorption be easier to, and substantially increases the health-care effect that human body is played by effect of Cordyceps.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of Cordyceps sinensis buccal tablets and preparation method thereof, be not only easier to absorb,
And the health care performance of Cordyceps can be strengthened.
For reaching above-mentioned purpose, the present invention provides following technical scheme:
Present invention firstly provides a kind of Cordyceps sinensis buccal tablets, the weight of its each component is as follows:
Cordyceps powder: 100 parts；
Herba Cynomorii powder: 150-300 part；
Malt extract is stuck with paste: 100-150 part；
Starch: 50-100 part；
Xylitol: 100-150 part.
Further, also include:
Micropowder silica gel 1-2 part；
Magnesium stearate 1-2 part；
Carboxymethyl cellulose 2-3 part.
The invention allows for the preparation method of a kind of Cordyceps sinensis buccal tablets described above, comprise the steps:
1) powder is beaten: take the water content (weight) Cordyceps more than or equal to 15% and pulverize under conditions of less than or equal to 0 DEG C, and will
Pulverize the direct lyophilizing of Cordyceps powder of gained, Cordyceps powder water content (weight) after lyophilizing not higher than 3%；Take water content (weight) big
Pulverize under conditions of less than or equal to 0 DEG C in the Herba Cynomorii equal to 20%, and the direct lyophilizing of Herba Cynomorii powder of gained will be pulverized, after lyophilizing
Herba Cynomorii powder water content (weight) not higher than 5%；
2) dispensing: Cordyceps sinensis buccal tablets component uniformly mixed according to weight, obtains Cordyceps mixed powder；
3) rehydration: the water ultrasonic atomizatio used by rehydration is become water smoke and inputs in described Cordyceps mixed powder；Stirring Cordyceps mixes simultaneously
Closing powder makes its water content (weight) uniformly be increased to 4-20%, obtains the Cordyceps rehydration powder that water content (weight) is 4-20%；
4) again by gained Cordyceps rehydration powder tabletting, described Cordyceps sinensis buccal tablets is prepared.
Further, described Cordyceps uses fresh Cordyceps.
Further, the particle diameter of described Cordyceps powder is less than or equal to 50um.
Further, the particle diameter of described Herba Cynomorii powder is less than or equal to 50um.
The beneficial effects of the present invention is:
The Cordyceps sinensis buccal tablets of the present invention, the Herba Cynomorii of interpolation has the kidney invigorating, benefit essence, moisturizes, cures mainly impotence and seminal emission, soreness of the waist and knees, dryness of the intestine
Constipation, to paralysis with improve that sexual function is weak to have certain effect, with Cordyceps to chronic cough of deficiency lung, asthma, hemoptysis of pulmonary tuberculosis,
Night sweat, effect such as soreness of waist and knee joint and impotence and seminal emission of suffering from a deficiency of the kidney complement each other, and are not only easier to absorb, and can strengthen the doctor of Cordyceps
Treat health properties；Mouthfeel is substantially improved by adding xylitol.
The preparation method of Cordyceps sinensis buccal tablets of the present invention, takes the way of lyophilizing the most completely so that it is the moisture in lyophilized powder is straight
Connecing and drop to lyophilizing terminal, then being calculated by the water content of Cordyceps rehydration powder after water content before rehydration and rehydration needs interpolation
Moisture weight；By ultrasound wave, the moisture calculated is atomized, by Cordyceps rehydration powder uniform wet rehydration；Make Cordyceps rehydration powder
Water content is precisely controlled, owing to the hydrone after atomization changes the surface nature of Cordyceps rehydration powder, and in this moistening
After Cordyceps rehydration powder on the basis of, it is easily operated directly to carry out tabletting, and buccal tablet tabletting rate is high, it is thus achieved that Cordyceps buccal tablet,
Can effectively preserve on the premise of effective ingredient do not loses, have water content low, constant product quality, tablet outward appearance is good, disintegrate
The advantages such as speed is fast, and effective ingredient dissolution is fast；Cordyceps powder and Herba Cynomorii powder is prepared, by Cordyceps powder and Herba Cynomorii powder under condition of ultralow temperature
Carrying out lyophilizing and obtain its lyophilized powder, its original effective ingredient can all be retained.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, so that those skilled in the art can be more preferable
Understand the present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
Embodiment 1
The preparation method of the Cordyceps sinensis buccal tablets of the present embodiment, comprises the steps:
1) powder is beaten: take the water content (weight) Cordyceps equal to 15% and pulverize under conditions of 0 DEG C, and the worm of gained will be pulverized
The direct lyophilizing of grass meal, Cordyceps powder water content (weight) after lyophilizing is 3%；Take the water content (weight) Herba Cynomorii equal to 20% at 0 DEG C
Under conditions of pulverize, and will pulverize gained the direct lyophilizing of Herba Cynomorii powder, Herba Cynomorii powder water content (weight) after lyophilizing is 5%；This reality
The Cordyceps executing example uses fresh Cordyceps；The particle diameter of Cordyceps powder is less than or equal to 50um；The granule of Herba Cynomorii powder is straight
Footpath is less than or equal to 50um.
2) dispensing: Cordyceps sinensis buccal tablets component uniformly mixed according to weight, obtains Cordyceps mixed powder；The present embodiment
Cordyceps sinensis buccal tablets, the weight of its each component is as follows: Cordyceps powder: 100 parts；Herba Cynomorii powder: 200 parts；Malt extract is stuck with paste: 120 parts；
Starch: 80 parts；Xylitol: 130 parts；Micropowder silica gel 2 parts；Magnesium stearate 1 part；Carboxymethyl cellulose 3 parts.
3) rehydration: the water ultrasonic atomizatio used by rehydration is become water smoke and inputs in Cordyceps mixed powder；Stirring Cordyceps mixes simultaneously
Closing powder makes its water content (weight) uniformly be increased to 15%, obtains the Cordyceps rehydration powder that water content (weight) is 15%；
4) again by gained Cordyceps rehydration powder tabletting, Cordyceps sinensis buccal tablets is prepared.
Embodiment 2
The preparation method of the Cordyceps sinensis buccal tablets of the present embodiment, comprises the steps:
1) powder is beaten: take the water content (weight) Cordyceps equal to 20% and pulverize under conditions of-5 DEG C, and the worm of gained will be pulverized
The direct lyophilizing of grass meal, Cordyceps powder water content (weight) after lyophilizing is 2%；Take the water content (weight) Herba Cynomorii equal to 30% at-5 DEG C
Under conditions of pulverize, and will pulverize gained the direct lyophilizing of Herba Cynomorii powder, Herba Cynomorii powder water content (weight) after lyophilizing is 3%；This reality
The Cordyceps executing example uses fresh Cordyceps；The particle diameter of Cordyceps powder is less than or equal to 50um；The granule of Herba Cynomorii powder is straight
Footpath is less than or equal to 50um.
2) dispensing: Cordyceps sinensis buccal tablets component uniformly mixed according to weight, obtains Cordyceps mixed powder；The present embodiment
Cordyceps sinensis buccal tablets, the weight of its each component is as follows: Cordyceps powder: 100 parts；Herba Cynomorii powder: 150 parts；Malt extract is stuck with paste: 150 parts；
Starch: 50 parts；Xylitol: 100 parts；Micropowder silica gel 1 part；Magnesium stearate 2 parts；Carboxymethyl cellulose 2 parts.
3) rehydration: the water ultrasonic atomizatio used by rehydration is become water smoke and inputs in Cordyceps mixed powder；Stirring Cordyceps mixes simultaneously
Closing powder makes its water content (weight) uniformly be increased to 4%, obtains the Cordyceps rehydration powder that water content (weight) is 4%；
4) again by gained Cordyceps rehydration powder tabletting, Cordyceps sinensis buccal tablets is prepared.
Embodiment 3
The preparation method of the Cordyceps sinensis buccal tablets of the present embodiment, comprises the steps:
1) powder is beaten: take the water content (weight) Cordyceps equal to 30% and pulverize under conditions of-10 DEG C, and gained will be pulverized
The direct lyophilizing of Cordyceps powder, Cordyceps powder water content (weight) after lyophilizing is 1%；Take water content (weight) equal to 25% Herba Cynomorii-
Pulverizing under conditions of 10 DEG C, and will pulverize the direct lyophilizing of Herba Cynomorii powder of gained, Herba Cynomorii powder water content (weight) after lyophilizing is 1%；
The Cordyceps of the present embodiment uses fresh Cordyceps；The particle diameter of Cordyceps powder is less than or equal to 50um；Herba Cynomorii powder
Grain diameter is less than or equal to 50um.
2) dispensing: Cordyceps sinensis buccal tablets component uniformly mixed according to weight, obtains Cordyceps mixed powder；The present embodiment
Cordyceps sinensis buccal tablets, the weight of its each component is as follows: Cordyceps powder: 100 parts；Herba Cynomorii powder: 300 parts；Malt extract is stuck with paste: 100 parts；
Starch: 100 parts；Xylitol: 150 parts；Micropowder silica gel 1.5 parts；Magnesium stearate 1.5 parts；Carboxymethyl cellulose 2.5 parts.
3) rehydration: the water ultrasonic atomizatio used by rehydration is become water smoke and inputs in Cordyceps mixed powder；Stirring Cordyceps mixes simultaneously
Closing powder makes its water content (weight) uniformly be increased to 20%, obtains the Cordyceps rehydration powder that water content (weight) is 20%；
4) again by gained Cordyceps rehydration powder tabletting, Cordyceps sinensis buccal tablets is prepared.
Embodiment 4
The preparation method of the Cordyceps sinensis buccal tablets of the present embodiment, comprises the steps:
1) powder is beaten: take the water content (weight) Cordyceps equal to 40% and pulverize under conditions of-8 DEG C, and the worm of gained will be pulverized
The direct lyophilizing of grass meal, Cordyceps powder water content (weight) after lyophilizing is 1.5%；Take the water content (weight) Herba Cynomorii equal to 40%-8
Pulverizing under conditions of DEG C, and will pulverize the direct lyophilizing of Herba Cynomorii powder of gained, Herba Cynomorii powder water content (weight) after lyophilizing is 2%；This
The Cordyceps of embodiment uses fresh Cordyceps；The particle diameter of Cordyceps powder is less than or equal to 50um；The granule of Herba Cynomorii powder
Diameter is less than or equal to 50um.
2) dispensing: Cordyceps sinensis buccal tablets component uniformly mixed according to weight, obtains Cordyceps mixed powder；The present embodiment
Cordyceps sinensis buccal tablets, the weight of its each component is as follows: Cordyceps powder: 100 parts；Herba Cynomorii powder: 250 parts；Malt extract is stuck with paste: 140 parts；
Starch: 60 parts；Xylitol: 120 parts；Micropowder silica gel 1.8 parts；Magnesium stearate 1.2 parts；Carboxymethyl cellulose 2.5 parts.
3) rehydration: the water ultrasonic atomizatio used by rehydration is become water smoke and inputs in Cordyceps mixed powder；Stirring Cordyceps mixes simultaneously
Closing powder makes its water content (weight) uniformly be increased to 15%, obtains the Cordyceps rehydration powder that water content (weight) is 15%；
4) again by gained Cordyceps rehydration powder tabletting, Cordyceps sinensis buccal tablets is prepared.
Embodiment described above is only the preferred embodiment lifted by absolutely proving the present invention, the protection model of the present invention
Enclose and be not limited to this.The equivalent that those skilled in the art are made on the basis of the present invention substitutes or conversion, all in the present invention
Protection domain within.Protection scope of the present invention is as the criterion with claims.
Claims (6)
1. a Cordyceps sinensis buccal tablets, it is characterised in that: the weight of its each component is as follows:
Cordyceps powder: 100 parts；
Herba Cynomorii powder: 150-300 part；
Malt extract is stuck with paste: 100-150 part；
Starch: 50-100 part；
Xylitol: 100-150 part.
Cordyceps sinensis buccal tablets the most according to claim 1 and preparation method thereof, it is characterised in that: also include:
Micropowder silica gel 1-2 part；
Magnesium stearate 1-2 part；
Carboxymethyl cellulose 2-3 part.
3. the preparation method being used for preparing Cordyceps sinensis buccal tablets as claimed in claim 1 or 2, it is characterised in that: include walking as follows
Rapid:
1) powder is beaten: take the water content (weight) Cordyceps more than or equal to 15% and pulverize under conditions of less than or equal to 0 DEG C, and will
Pulverize the direct lyophilizing of Cordyceps powder of gained, Cordyceps powder water content (weight) after lyophilizing not higher than 3%；Take water content (weight) big
Pulverize under conditions of less than or equal to 0 DEG C in the Herba Cynomorii equal to 20%, and the direct lyophilizing of Herba Cynomorii powder of gained will be pulverized, after lyophilizing
Herba Cynomorii powder water content (weight) not higher than 5%；
2) dispensing: Cordyceps sinensis buccal tablets component uniformly mixed according to weight, obtains Cordyceps mixed powder；
3) rehydration: the water ultrasonic atomizatio used by rehydration is become water smoke and inputs in described Cordyceps mixed powder；Stirring Cordyceps mixes simultaneously
Closing powder makes its water content (weight) uniformly be increased to 4-20%, obtains the Cordyceps rehydration powder that water content (weight) is 4-20%；
4) again by gained Cordyceps rehydration powder tabletting, described Cordyceps sinensis buccal tablets is prepared.
The preparation method of Cordyceps sinensis buccal tablets the most according to claim 3, it is characterised in that: described Cordyceps uses the fresh winter
Worm summer grass.
The preparation method of Cordyceps sinensis buccal tablets the most according to claim 3, it is characterised in that: the particle diameter of described Cordyceps powder is less than
Equal to 50um.
The preparation method of Cordyceps sinensis buccal tablets the most according to claim 3, it is characterised in that: the particle diameter of described Herba Cynomorii powder is less than
Equal to 50um.
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| CN201610333825.4A CN105998099A (en) | 2016-05-19 | 2016-05-19 | Cordyceps sinensis buccal tablet and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109355198A (en) * | 2018-10-30 | 2019-02-19 | 广东海天创新技术有限公司 | A kind of culture medium and the preparation method and application thereof for the fermentation of microbe in solid state flux |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201492711U (en) * | 2009-05-31 | 2010-06-02 | 张雪峰 | Cordyceps sinensis tablet |
| CN103040877A (en) * | 2012-11-30 | 2013-04-17 | 陈玉龙 | Preparation method of cordyceps sinensis micropowder lozenges |
| CN105456314A (en) * | 2015-12-14 | 2016-04-06 | 梁文成 | Radix angelicae sinensis and cordyceps sinensis buccal tablet and preparation method thereof |
-
2016
- 2016-05-19 CN CN201610333825.4A patent/CN105998099A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201492711U (en) * | 2009-05-31 | 2010-06-02 | 张雪峰 | Cordyceps sinensis tablet |
| CN103040877A (en) * | 2012-11-30 | 2013-04-17 | 陈玉龙 | Preparation method of cordyceps sinensis micropowder lozenges |
| CN105456314A (en) * | 2015-12-14 | 2016-04-06 | 梁文成 | Radix angelicae sinensis and cordyceps sinensis buccal tablet and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109355198A (en) * | 2018-10-30 | 2019-02-19 | 广东海天创新技术有限公司 | A kind of culture medium and the preparation method and application thereof for the fermentation of microbe in solid state flux |
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Application publication date: 20161012 |