CN103933192B - A kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine - Google Patents
A kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine Download PDFInfo
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- CN103933192B CN103933192B CN201410167095.6A CN201410167095A CN103933192B CN 103933192 B CN103933192 B CN 103933192B CN 201410167095 A CN201410167095 A CN 201410167095A CN 103933192 B CN103933192 B CN 103933192B
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Abstract
The relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, belongs to technical field of Chinese medicines.It is characterized in that comprising the following steps: 1) percentage composition takes Ganoderma 5-10%, Fructus Hippophae 4-8%, Herba Peristrophis Roxburghianae 6-12%, Herba Houttuyniae 8-15%, Flos Lonicerae 20-30%, Flos Eriobotryae 10-15%, pear 9-12%, Mel 5-8% by weight; 2) wall breaking pulverization; 3)? wet ball grinding is pulverized; 4) decoct, collect filtrate; 5) vacuum film concentrate drying, obtains relieving cough and resolving phlegm preparation.Above-mentioned a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, adopt and have that the crude drug of relieving cough and resolving phlegm is composite to be made, to relieving cough and resolving phlegm, there is synergistic function, and remain that the bioactive ingredients of Chinese crude drug, granularity are little, good evenness and dissolution rate high, its dissolving in vivo, infiltration rate can be accelerated, improve its absorbtivity, therapeutic effect is good.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine.
Background technology
The Chinese herbal medicine of relieving cough and resolving phlegm is a lot, and existing Chinese herbal medicine generally adopts high-temperature water boiling standby, and in water cooking liquid, the biological activity of Chinese crude drug is easily destroyed, and dissolution rate is not high, and effective component content is not high, affects therapeutic effect.
Summary of the invention
For prior art Problems existing, the object of the invention is to design the technical scheme that a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine is provided, adopt and have that the crude drug of relieving cough and resolving phlegm is composite to be made, to relieving cough and resolving phlegm, there is synergistic function, and remain that the bioactive ingredients of Chinese crude drug, granularity are little, good evenness and dissolution rate high, can accelerate its dissolving in vivo, infiltration rate, improve its absorbtivity, therapeutic effect is good.
Described a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, is characterized in that comprising the following steps:
1) percentage composition takes Ganoderma 5-10%, Fructus Hippophae 4-8%, Herba Peristrophis Roxburghianae 6-12%, Herba Houttuyniae 8-15%, Flos Lonicerae 20-30%, Flos Eriobotryae 10-15%, pear 9-12%, Mel 5-8% by weight; Pulverize after Ganoderma, Fructus Hippophae, Herba Peristrophis Roxburghianae, Herba Houttuyniae, Flos Lonicerae, Flos Eriobotryae drying with pulverizer, cross 20-30 mesh sieve; Filter after being squeezed the juice by pear, it is for subsequent use that snow pear juice adds Mel;
2) wall breaking pulverization: by the Ganoderma in step 1), Fructus Hippophae, Herba Peristrophis Roxburghianae, Herba Houttuyniae, Flos Lonicerae, Flos Eriobotryae mixed powder, be crushed to 60-70 μm through super micron mill, obtain breaking cellular wall fine powder;
3) wet ball grinding is pulverized: by step 2) fine powder that obtains adds ball mill wet ball grinding and pulverizes, and the weight ratio of fine powder raw material and water is 1:5-6, and drum's speed of rotation is 300-400rpm, through 1-2 hour ball milling breaking cellular wall, obtains ball milling wall cell disruption powder;
4) ball milling wall cell disruption powder in step 3) is added raw material weight 3-5 water soaking 2-3h doubly, then 100 DEG C of big fire decoct 30-40min, then use little fire decoction 5-10min instead, and cold filtration, collects filtrate;
5) in filtrate, add pear Mel juice, then at 70-80 DEG C, vacuum is 0.09Mpa, and feed liquor flow velocity is 200-300mLmin
-1condition under carry out vacuum film concentrate drying, obtain relieving cough and resolving phlegm preparation.
Described a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, is characterized in that in step 1): Ganoderma 6-8%, Fructus Hippophae 5-6%, Herba Peristrophis Roxburghianae 8-10%, Herba Houttuyniae 9-12%, Flos Lonicerae 22-28%, Flos Eriobotryae 12-13%, pear 10-11%, Mel 6-7%.
Described a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, is characterized in that in step 1): Ganoderma 7%, Fructus Hippophae 6%, Herba Peristrophis Roxburghianae 12%, Herba Houttuyniae 15%, Flos Lonicerae 30%, Flos Eriobotryae 13%, pear 11%, Mel 6%.
Described a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, is characterized in that step 2) in: wall breaking pulverization to 650 μm.
Described a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, is characterized in that in step 3): the weight ratio of fine powder raw material and water is 1:5.5, and drum's speed of rotation is 350rpm.
Described a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, is characterized in that in step 4): the water soaking 2.5h adding raw material weight 4 times, and then 100 DEG C of big fire decoct 35min, then uses little fire decoction 6-8min instead.
Ganoderma, cures ten thousand diseases, and its function is come ture, the well-informed magical effect, therefore named Ganoderma, has another name called " not dead medicine " and is commonly called as " Ganoderma lucidum seu Japonicum ", Polyporaceae class, annual fungus, wherein particularly famous with Changbai Mountain red ganoderma.The chemical composition of Ganoderma is comparatively complicated, and different because strain used, the strain place of production, cultural method, extraction process, formulation method are different.Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, has phlegm-dispelling functions to respiratory system, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.
Fructus Hippophae, be a kind of fallen leaves property shrub, its characteristic is drought-enduring, anti-blown sand, can survive on wetland with saline-alkaline, is therefore widely used in water and soil conservation.Sea buckthorn fruit is used as medicine and has effect of relieving cough and resolving phlegm, invigorating the stomach and promoting digestion, promoting blood circulation to remove blood stasis.
Herba Peristrophis Roxburghianae is the herb of acanthaceous plant mountain indigo plant, clearing away lung-heat to relieve cough, and dissipating blood stasis stops blooding.For hemoptysis of pulmonary tuberculosis, pneumonia, diabetes; External is controlled traumatic injury and is swollen and ache.
Herba Houttuyniae, have another name called Herba Houttuyniae, cut youngster's root, hog snout encircles, Herba Houttuyniae, taxonomy belongs to dicotyledon Saururaceae Houttuynia, is a kind of herbaceous plant with fishy smell.On the south China Yangtze river basin, all there is distribution each province.Herba Houttuyniae acrid in the mouth, cold, heat-clearing and toxic substances removing, detumescence can treat skin ulcer, promoting urination to remove dampness, clearing away heat to cure dysentery, invigorating the stomach and promoting digestion, by the lung abscess, sore swollen toxin, hemorrhoidal hemorrhage, retention of heat in the spleen and stomach etc. of controlling excess-heat, pyretic toxicity, damp, disease heat are trouble.Modern pharmacology experiment shows, this product has the effect such as antibacterial, antiviral, raising immunity of organisms, diuresis.
Flos Lonicerae, has another name called Radix Ophiopogonis, owing to opening as white at the beginning of Flos Lonicerae, after transfer yellow to, hence obtain one's name Flos Lonicerae.Medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or is with the flower just opened.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.
Flos Eriobotryae, is the flower of rosaceous plant Folium Eriobotryae, controls Common Cold, cough expectorant blood.
Pear, moistening lung and clearing heat, promoting the production of body fluid to quench thirst, use same with crystal sugar, strengthens the abundant antitussive action of profit, can treat the diseases such as children's xeropulmonary cough, dry cough without phlegm, dry lip dry pharynx.
The honey of nectar brew in Nidus Vespae that Mel is insecticide Apis to be adopted from the spending of flowering plant.Mel has convergence, nutrition and Promotive union effect to wound surface, has lubricity to eliminate the phlegm and laxative effective.
Above-mentioned a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, adopt and have that the crude drug of relieving cough and resolving phlegm is composite to be made, to relieving cough and resolving phlegm, there is synergistic function, and remain that the bioactive ingredients of Chinese crude drug, granularity are little, good evenness and dissolution rate high, its dissolving in vivo, infiltration rate can be accelerated, improve its absorbtivity, therapeutic effect is good.
The percentage composition related in present specification unless otherwise indicated, all refers to weight percentage.
Detailed description of the invention
Now in conjunction with embodiments of the invention and correlation test, the invention will be further described.
Embodiment 1
1) percentage composition takes Ganoderma 5-10%, Fructus Hippophae 4-8%, Herba Peristrophis Roxburghianae 6-12%, Herba Houttuyniae 8-15%, Flos Lonicerae 20-30%, Flos Eriobotryae 10-15%, pear 9-12%, Mel 5-8% by weight; Pulverize after Ganoderma, Fructus Hippophae, Herba Peristrophis Roxburghianae, Herba Houttuyniae, Flos Lonicerae, Flos Eriobotryae drying with pulverizer, cross 20-30 mesh sieve; Filter after being squeezed the juice by pear, it is for subsequent use that snow pear juice adds Mel;
2) wall breaking pulverization: by the Ganoderma in step 1), Fructus Hippophae, Herba Peristrophis Roxburghianae, Herba Houttuyniae, Flos Lonicerae, Flos Eriobotryae mixed powder, be crushed to 65 μm through super micron mill, obtain breaking cellular wall fine powder;
3) wet ball grinding is pulverized: by step 2) fine powder that obtains adds ball mill wet ball grinding and pulverizes, and the weight ratio of fine powder raw material and water is 1:5.5, and drum's speed of rotation is 350rpm, through 1.5 hours ball milling breaking cellular walls, obtains ball milling wall cell disruption powder;
4) ball milling wall cell disruption powder in step 3) is added the water soaking 2.5h of raw material weight 4 times, then 100 DEG C of big fire decoct 35min, then use little fire decoction 8min instead, and cold filtration, collects filtrate;
5) in filtrate, add pear Mel juice, then at 75 DEG C, vacuum is 0.09Mpa, and feed liquor flow velocity is 250mLmin
-1condition under carry out vacuum film concentrate drying, obtain relieving cough and resolving phlegm preparation.
Above-mentioned steps 2) in micronizing to 60 or 70 μm; In step 3), the weight ratio of fine powder raw material and water is 1:5 or 1:6, and drum's speed of rotation is 300 or 400rpm, through 1 or 2 hour ball milling breaking cellular wall, obtains ball milling wall cell disruption powder; Add water soaking 2 or the 3h of raw material weight 3 or 5 times in step 4), then 100 DEG C of big fire decoct 30min or 40min, then use little fire instead and decoct 5min or 10min; In step 5) at 70 DEG C or 80 DEG C vacuum drying, feed liquor flow velocity is 200 or 300mLmin
-1, the other the same as in Example 1, also can obtain beneficial effect of the present invention.
Beneficial effect of the present invention is further illustrated below by way of corresponding test.
Test one: the patient 200 examples being suffered from relieving cough and resolving phlegm is divided into three treatment groups, wherein male 100 example, women 100 example, the oldest person 55 years old, reckling 15 years old.Three treatment groups take relieving cough and resolving phlegm preparation (embodiment 1) respectively, carry out clinical observation on the therapeutic effect.Instructions of taking: 2 times on the one, a 2-3 gram, warm water is dissolved and is taken, and therapeutic effect is in table 1.
Test two: below by way of microbiological indicator and content of beary metal test the invention will be further described, in table 2.
Above-mentioned test determination result shows, microorganism, the content of beary metal of the relieving cough and resolving phlegm preparation of embodiment 1 preparation are humble, meet green industry standard and green food standard.
Claims (4)
1. the relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine, is characterized in that comprising the following steps:
1) percentage composition takes Ganoderma 5-10%, Fructus Hippophae 4-8%, Herba Peristrophis Roxburghianae 6-12%, Herba Houttuyniae 8-15%, Flos Lonicerae 20-30%, Flos Eriobotryae 10-15%, pear 9-12%, Mel 5-8% by weight; Pulverize after Ganoderma, Fructus Hippophae, Herba Peristrophis Roxburghianae, Herba Houttuyniae, Flos Lonicerae, Flos Eriobotryae drying with pulverizer, cross 20-30 mesh sieve; Filter after being squeezed the juice by pear, it is for subsequent use that snow pear juice adds Mel;
2) wall breaking pulverization: by the Ganoderma in step 1), Fructus Hippophae, Herba Peristrophis Roxburghianae, Herba Houttuyniae, Flos Lonicerae, Flos Eriobotryae mixed powder, be crushed to 60-70 μm through super micron mill, obtain breaking cellular wall fine powder;
3) wet ball grinding is pulverized: by step 2) fine powder that obtains adds ball mill wet ball grinding and pulverizes, and the weight ratio of fine powder raw material and water is 1:5-6, and drum's speed of rotation is 300-400rpm, through 1-2 hour ball milling breaking cellular wall, obtains ball milling wall cell disruption powder;
4) ball milling wall cell disruption powder in step 3) is added raw material weight 3-5 water soaking 2-3h doubly, then 100 DEG C of big fire decoct 30-40min, then use little fire decoction 5-10min instead, and cold filtration, collects filtrate;
5) in filtrate, add pear Mel juice, then at 70-80 DEG C, vacuum is 0.09Mpa, and feed liquor flow velocity is 200-300mLmin
-1condition under carry out vacuum film concentrate drying, obtain relieving cough and resolving phlegm preparation.
2. a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine as claimed in claim 1, is characterized in that in step 1): Ganoderma 7%, Fructus Hippophae 6%, Herba Peristrophis Roxburghianae 12%, Herba Houttuyniae 15%, Flos Lonicerae 30%, Flos Eriobotryae 13%, pear 11%, Mel 6%.
3. a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine as claimed in claim 1, is characterized in that in step 3): the weight ratio of fine powder raw material and water is 1:5.5, and drum's speed of rotation is 350rpm.
4. a kind of relieving cough and resolving phlegm preparation extracted from Chinese herbal medicine as claimed in claim 1, is characterized in that in step 4): the water soaking 2.5h adding raw material weight 4 times, and then 100 DEG C of big fire decoct 35min, then uses little fire instead and decoct 6-8min.
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| 刘红等.小儿清热止咳口服液药效学实验研究.《河南职工医学院学报》.2002,第14卷(第1期), * |
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Effective date of registration: 20180625 Address after: 301712 east side of Chengguan Town North Ring Road in Wuqing District, Tianjin Patentee after: Medicine company limited company of Tianjin China and Sweden Address before: 301700 room 214, building 7, Beijing Bin Industrial Park, Wuqing Development Zone, Tianjin. Patentee before: Tianjin Jetion Power Co., Ltd. |
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