CN107737206A - A kind of Chinese medicine composition for treating secretory otitis media and preparation method thereof - Google Patents

A kind of Chinese medicine composition for treating secretory otitis media and preparation method thereof Download PDF

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CN107737206A
CN107737206A CN201711281919.2A CN201711281919A CN107737206A CN 107737206 A CN107737206 A CN 107737206A CN 201711281919 A CN201711281919 A CN 201711281919A CN 107737206 A CN107737206 A CN 107737206A
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chinese medicine
otitis media
medicine composition
root
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谭仁燕
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Abstract

The present invention relates to a kind of Chinese medicine composition for treating secretory otitis media and preparation method thereof.The Chinese medicine composition is to be prepared from the following materials:The root of bidentate achyranthes, asafoetide, kelp, asarum, Ramulus Taxilli, the achene of Siberian cocklebur, cortex albiziae, dracontomelon duperreanum, comospore Glochidion puberum, the root of bidentate achyranthes, balloonflower root, Flos Ilicis Asprellae, red green onion, paniculate swallowwort, cockscomb, radix pseudostellariae, honey raisin tree.The Chinese medicine composition can effectively improve the various malaise symptoms of secretory otitis media, have good therapeutic effect to secretory otitis media.

Description

A kind of Chinese medicine composition for treating secretory otitis media and preparation method thereof
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating secretory otitis media and its preparation side Method.
Background technology
Secretory otitis media is the middle ear apyetous inflammatory disease using hydrotympanum and Hearing as principal character, in Doctor thinks secretory otitis media category " wind is deaf ", " Erzhang-erbi ", " distending pain of ear ", the category of " ear numbness ".Its interpretation of the cause, onset and process of an illness is mostly that ailment said due to cold or exposure is invaded Attack, through gas ruffian plug, or phlegm wet turbid pathogenic factor, upper poly- ear key or evil poison are detained, qi and blood stagnation.The main points of its diagnosis and treatment based on an overall analysis of the illness and the patient's condition are:
1st, the stagnant key of ailment said due to cold or exposure:Swollen vexed or hypodynia, tinnitus and dysacousis in ear are felt after flu, is strengthened from sound, otopiesis, color Redness is swollen or sees fluid level.With fever and aversion to wind, nasal obstruction runny nose etc..Control suitable dispelling wind and dissipate heresy, promoting the circulation of qi a surname's ruffian.
2nd, the poly- ear of phlegm wet:Heavier, Hearing is felt in swollen vexed occlusion in ear, strengthens from sound, there is water sound when shaking the head in ear.Inspection Look into and see that eardrum has arc horizontal line or eardrum evagination.Whole body has nose heave dizziness, lassitude hypodynamia more, and the light abdomen of mouth is expired;Pale tongue with greasy fur, arteries and veins Moisten or sliding.Suitable invigorating the spleen rises clearly, and dampness removing is sensible.
3rd, qi and blood stasis of blood network:There are inaccessible sense, dysacousis in ear, tinnitus is gradually risen, is not with the passing of time cured.Otopiesis is obvious, or has Thicken, calcinosis, adhesion atrophy;Dimly red tongue, uneven pulse.Control preferably it is promoting blood circulation and removing obstruction in channels, clever ear is had one's ideas straightened out.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition for treating secretory otitis media;
It is a further object of the present invention to provide a kind of Chinese medicine composition preparation method for treating secretory otitis media.
The purpose of the present invention is realized by following technical scheme:
It is of the present invention treatment secretory otitis media Chinese medicine composition, it be by including following parts by weight raw material prepare and Into:
Root of bidentate achyranthes 30-50 parts, asafoetide 25-40 parts, kelp 15-30 parts, asarum 5-15 parts, Ramulus Taxilli 10-30 parts, achene of Siberian cocklebur 5-15 Part, cortex albiziae 3-10 parts, dracontomelon duperreanum 8-20 parts, comospore Glochidion puberum 5-10 parts, root of bidentate achyranthes 20-40 parts, balloonflower root 5-15 parts, Flos Ilicis Asprellae 8-20 Part, red green onion 20-40 parts, paniculate swallowwort 15-30 parts, cockscomb 15-30 parts, radix pseudostellariae 15-30 parts, honey raisin tree 15-30 parts.
Preferably, it is to be prepared by the raw material including following parts by weight:
Root of bidentate achyranthes 35-45 parts, asafoetide 30-35 parts, kelp 20-25 parts, asarum 8-12 parts, Ramulus Taxilli 15-25 parts, achene of Siberian cocklebur 8-12 Part, cortex albiziae 5-8 parts, dracontomelon duperreanum 10-15 parts, comospore Glochidion puberum 7-9 parts, root of bidentate achyranthes 25-35 parts, balloonflower root 8-12 parts, Flos Ilicis Asprellae 10-15 Part, red green onion 25-35 parts, paniculate swallowwort 20-25 parts, cockscomb 20-25 parts, radix pseudostellariae 20-25 parts, honey raisin tree 20-25 parts.
It is the crude drug source of Chinese medicine composition of the present invention below:
Sculellaria barbata, it is the dry of labiate Sculellaria barbata Scutellaria barbata Don [S. rivularis Wall] Dry herb.【Nature and flavor】It is pungent, bitter, tremble with fear.【Channel tropism】Return lung, liver and kidney channel.【Major function】It is clearing heat and detoxicating, stagnation resolvation diuresis.For Furuncle swelling toxin, abscess of throat, venomous snake bite, the pain of injury caused by falling and tumbling, oedema, jaundice.
Asafoetide, it is samphire Ferula sinkiangensis Ferula sinkiangensis K. M. Shen or Ferula fukanensis K.M.Shen Ferula fukanensis K. M. Shen resin.【Nature and flavor】It is bitter, pungent, temperature.【Channel tropism】Returns spleen, stomach.【Function master Control】Disperse accumulations, dissipate ruffian, desinsection.For meat stagnation, hemostasis abdominal mass, mass in abdomen, abdominal pain due to enterositosis.
Kelp, it is Laminariaceae plant sea-tangle Laminaria japonica Aresch. or Alariaceae plant kelp(Goose slaps Dish)Ecklonia kurome Okam. drying thallus.【Nature and flavor】It is salty, tremble with fear.【Channel tropism】Return liver, stomach, kidney channel.【Function master Control】Softening and resolving hard mass, dissolving phlegm, Li Shui.For goiter and tumor, scrofula, testiclar gall, phlegm and retained fluid oedema.
Asarum, it is aristolochiaceae plant Herba Asari Asarum heterotropoides Fr. Schmidt var.mandshuricum(Maxim.)Kitag., Seoul asarum Asarum sieboldii Miq. var. seoulense Nakai or asarum sieboldii Asarum sieboldii Miq. drying herb.It is pungent, temperature.The thoughts of returning home, lung, kidney channel.Expelling wind and clearing away cold, it is sensible Analgesic, Wenfei of drink.For anemofrigid cold, have a headache, toothache, nasosinusitis of having a stuffy nose, arthralgia pain due to rheumatism, sputum cough.
Ramulus Taxilli, it is Loranthaceae plant Ramulus Taxilli Taxillus chinensis(DC.)Danser dry zone leaf Stem branch.Bitter, sweet, flat.Return liver and kidney channel.Filling liver kidney, strengthening the bones and muscles, wind-damp dispelling, antiabortive member.For arthralgia pain due to rheumatism, soreness and weakness of waist and knees, muscle Bone is powerless, and uterine bleeding passes through more, blood leaking in gestation, fetal irritability;Hypertension.
The achene of Siberian cocklebur, it is feverfew Siberian cocklebur Xanthium sibiricum Patr. fruit of the drying and ripening with involucre. It is pungent, bitter, temperature;It is poisonous.Return lung passes through.Dissipate wind dehumidifying, clearing the nasal passage.For anemofrigid headache, nasosinusitis runny nose, rubella itch, arthritis with fixed pain caused by dampness contraction.
Cortex albiziae, it is legume silk tree Albizia julibrissin Durazz. dry bark.It is sweet, put down.Return The heart, liver, lung channel.Resolving stagnation for tranquilization, activating blood circulation and reducing swelling.For confused and worried, melancholy insomnia, lung carbuncle sore swells, the pain of injury caused by falling and tumbling.
Dracontomelon duperreanum, Anacardiaceae dracontomelon duperreanum Dracontomelon dao(Blanco)Merr. et Rolfe, it is used as medicine with fruit. 【Nature and flavor】It is sweet;Acid;It is cool in nature【Channel tropism】Spleen;Stomach;Liver Channel【Major function】Stomach invigorating;Promote the production of body fluid;Sober up;Removing toxic substances.Main poor appetite; Pyreticosis is thirsty;It is drunk;Abscess of throat;Pathogenic wind-toxic sore is itched.
Comospore Glochidion puberum, it is Euphorbiaceae Glochidion plant comospore Glochidion puberum Glochidion eriocarpum Champ., it is used as medicine with root and leaf.【Nature and flavor】It is bitter, puckery, put down.【Major function】Clearing heat and promoting diuresis, detoxifying and relieving itching.Root:Enteritis, dysentery Disease.Leaf:Raw lacquer allergy, paddy-field dermatitis, skin itching, nettle rash, eczema, exfoliative dermatitis are controlled in external application.
The root of bidentate achyranthes, it is amaranthaceous plant root of bidentate achyranthes Achyranthes bidentata Blume. dry root.Nature and flavor】Bitter, acid, It is flat.【Channel tropism】Return liver and kidney channel.【Major function】Filling liver kidney, strengthening the bones and muscles, dispelling stasis of blood and stimulating the menstrual flow, ensuring proper downward flow of the blood.For soreness of waist and knee joint, Muscles and bones is powerless, Amenorrhea abdominal mass, dizziness due to hyperactivity of liver-YANG.
Balloonflower root, it is Campanulaceae balloonflower root Platycodon grandiflorum(Jacq.)A.DC. dry root.【Property Taste】It is bitter, pungent, put down.【Channel tropism】Return lung passes through.【Major function】Facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, it is uncomfortable in chest not Freely, pharyngalgia, sound is mute, lung carbuncle pyemesis, and sore purulence is not into bursting.
Flos Ilicis Asprellae, Aquifoliaceae Holly leaf of plum Chinese ilex Ilex asprella(Hook. et Arn.) Champ. ex Benth., it is used as medicine with root, leaf.【Nature and flavor】It is bitter, sweet, it is cool.【Major function】It is clearing heat and detoxicating, promote the production of body fluid to quench thirst.For catching a cold, high fever Polydipsia, tonsillitis, sphagitis, tracheitis, pertussis, enteritis, dysentery, catarrhal jaundice, wild gill fungus, arsenic intoxication.For herbal tea Primary raw material;Traumatic injury, carbuncle furuncle poison are controlled in leaf external application.
Red green onion, the red green onion Eleutherine americana Merr. ex K. Heyne of Iridaceae(E. plicata Herb.), it is used as medicine with herb, bulb.【Nature and flavor】Hardship, it is cool.【Major function】It is clearing heat and detoxicating, eliminating stasis to subdue swelling, hemostasis.
Paniculate swallowwort, Asclepiadaceae Cynanchum plant paniculate swallowwort Cynanchum paniculatum(Bge.)Kitag. Dry root and rhizome.【Nature and flavor】It is pungent, temperature.【Channel tropism】Return liver, stomach.【Major function】Wind-dispelling dampness elimination, antalgesic-antipruritic.For Arthralgia pain due to rheumatism, turgor of having a stomachache, toothache, pain in the back, injury from falling down, nettle rash, eczema.
Cockscomb, it is amaranthaceous plant cockscomb Celosia cristata L. drying inflorescence.It is sweet, puckery, it is cool.Return liver, Large intestine channel.Astringing to arrest bleeding, stop-band, stop dysentery.For spitting blood, uterine bleeding, have blood in stool, hemorrhoid blood, leukorrhea with reddish discharge, protracted dysentery is more than.
Radix pseudostellariae, it is pinkwort caryophyllaceous ginseng Pseudostellaria heterophylla(Miq.)Pax ex Pax et Hoffm. dried root.Sweet, slight bitter, put down.Returns spleen, lung channel.Replenish qi to invigorate the spleen, it is promoting production of body fluid and nourishing the lung.It is tired for insufficiency of the spleen body, Poor appetite, eak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Honey raisin tree, alias:Papaw, Drung nationality river trifoliate orange Dulcis, Rhizoma Coptidis, golden hook pears, honey raisin tree, smelly matrimony vine, chicken feet, dragon's paw, chicken Pawl pears(Hakka), knot basket etc., Latin literary fame Hovenia dulcis. Rhamnaceaes, trifoliate orange Dulcis category deciduous trees carry succulent fruit The fruits and seedses of handle.Sweet acid, put down.Enter the heart, spleen two passes through.Drunk, dysphoria with smothery sensation is controlled, thirsty, vomiting, difficulty in urination and defecation.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and this method is It is prepared using the ethanol extraction using water extraction or 40-80% concentration expressed in percentage by volumes.Specific preparation method is as follows:
Scheme one:Take whole medicinal materials, extracting in water 2-3 times after mixing, each amount of water equivalent to 6-12 times of medicinal material gross weight, Each extraction time is 1-3 hours, merges extract solution, filtration, relative density is 1.15-1.20 when filtrate is concentrated into 70-80 DEG C Clear cream, produce active component.
Scheme two:Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs after mixing, each ethanol consumption is medicinal material total amount 4-10 times, extraction time is 1-4 hours, merge extract solution, filtering, relative density is when filtrate is concentrated into 70-80 DEG C 1.15-1.20 clear cream, produces active component.
Scheme three:Whole medicinal materials are taken, extracting in water 2-3 times after mixing, 6- of each amount of water equivalent to medicinal material gross weight 12 times, each extraction time is 1-3 hours, merges extract solution, filtration, relative density is when filtrate is concentrated into 70-80 DEG C 1.15-1.20 clear cream, ethanol is added, it is 40-70% to make alcohol content, stands 12-24 hours, and filtration, filtrate is concentrated into 70-80 DEG C when relative density be 1.10-1.25 medicinal extract, produce active component.
It is of the present invention treatment secretory otitis media Chinese medicine, can also with pharmaceutically acceptable carrier combination, Various oral formulations, such as tablet, capsule, oral liquid, syrup, mixture are made.
The pharmaceutically acceptable carrier of the present invention includes but is not limited to following:
Oral formulations:
Diluent:Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive:Purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant:Starch, sodium carboxymethyl starch, cellulose derivative, PVPP etc..
Lubricant:Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent:Water, ethanol, glycerine, propane diols, liquid paraffin, vegetable oil etc..
Flavouring:Sucrose, monose, aromatic etc..
Preservative:Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1:Tablet
Scheme one is taken to add tablet and often use auxiliary material one of to the gained active component of scheme three, routinely production method is prepared into Invention tablet.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 1:Capsule
Scheme one is taken to add capsule and often use auxiliary material, routinely production method is prepared into one of to the gained active component of scheme three Capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrant, lubricant or whole with auxiliary material.
Method 3:Syrup
Scheme one is taken to add syrup and often use auxiliary material, routinely production method is prepared into one of to the gained active component of scheme three Syrup of the present invention.
Above-mentioned syrup often includes one of flavouring, preservative, cosolvent or whole with auxiliary material.
Method 4:Mixture
Scheme one is taken to add mixture and often use auxiliary material one of to the gained active component of scheme three, routinely production method is prepared into Invention mixture.
Above-mentioned mixture often includes one of flavouring, preservative or whole with auxiliary material.
Method 5:Oral liquid
Scheme one is taken dissolving after-purification, concentration, to add oral liquid and often use auxiliary material, by normal one of to the gained active component of scheme three Rule production method is prepared into oral liquid of the present invention.
Above-mentioned oral liquid often includes one of flavouring, preservative, cosolvent or whole with auxiliary material.
The applicant refers to modern pharmacological research achievement on the basis of Traditional Chinese Medicine Coryza Treated by Syndrome Differentiation is studied, by for many years Experiment, multiple formulations are screened, have found the Chinese medicine preparation that can effectively treat secretory otitis media.
Chinese medicine composition active ingredient disclosed in this invention is by the root of bidentate achyranthes, asafoetide, kelp, asarum, Ramulus Taxilli, Siberian cocklebur It is prepared by son, cortex albiziae, dracontomelon duperreanum, comospore Glochidion puberum, the root of bidentate achyranthes, balloonflower root, Flos Ilicis Asprellae, red green onion, paniculate swallowwort, cockscomb, radix pseudostellariae, honey raisin tree Form.The mutually collaboration of full side, has dispelling wind dampness removing, sensible active effect, has good therapeutic effect to secretory otitis media.
A kind of Chinese medicine composition for treating secretory otitis media provided by the invention has advantages below:
1st, composite preparation provided by the invention is safe and effective, has dispelling wind dampness removing, sensible active effect, to secretory otitis media There is good therapeutic effect.
2nd, clinical tests prove that, patient after traditional Chinese medicine composition for treating of the present invention, patients with secretory otitis media Total effective rate is up to 97.4%, and each symptom compared with pre-treatment, is significantly improved after treatment.
3rd, Chinese medicinal composition preparation provided by the invention, scientific formulation is reasonable, and technique is simple, in good taste, and cost is low.
Embodiment
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate The present invention rather than limitation of the present invention.The present invention is belonged to according to the simple modifications that the essence of the present invention is carried out to the present invention Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution Volume ratio.
The oral liquid of embodiment 1
Weigh root of bidentate achyranthes 3kg, asafoetide 2.5kg, kelp 1.5kg, asarum 0.5kg, Ramulus Taxilli 1kg, achene of Siberian cocklebur 0.5kg, cortex albiziae 0.3kg, dracontomelon duperreanum 0.8kg, comospore Glochidion puberum 0.5kg, root of bidentate achyranthes 2kg, balloonflower root 0.5kg, Flos Ilicis Asprellae 0.8kg, red green onion 2kg, paniculate swallowwort 1.5kg, cockscomb 1.5kg, radix pseudostellariae 1.5kg, honey raisin tree 1.5kg.Extracting in water 2 times, amount of water is respectively medicinal material gross weight twice 10 times, 8 times of amount, extraction time is respectively 2 hours, 1 hour twice, merges extract solution, filtration, and filtrate is concentrated into 80 DEG C of phases To the medicinal extract that density is 1.10, addition auxiliary material mannitol, sorbic acid, water stir in medicinal extract, dispense, and oral liquid is made.
The tablet of embodiment 2
Weigh root of bidentate achyranthes 5kg, asafoetide 4kg, kelp 3kg, asarum 1.5kg, Ramulus Taxilli 3kg, achene of Siberian cocklebur 1.5kg, cortex albiziae 1kg, people Face 2kg, comospore Glochidion puberum 1kg, root of bidentate achyranthes 4kg, balloonflower root 1.5kg, Flos Ilicis Asprellae 2kg, red green onion 4kg, paniculate swallowwort 3kg, cockscomb 3kg, Radix pseudostellariae 3kg, honey raisin tree 3kg.Extracted 3 times with 40% alcohol reflux, each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, 4 Times, extraction time is distinguished 3 hours, 2 hours, 1 hour, merges extract solution, filtering, relative density is 1.25 when filtrate concentrates 60 DEG C Medicinal extract, add supplementary product starch, ethanol, talcum powder, be made tablet.
The granule of embodiment 3
Weigh root of bidentate achyranthes 3.5kg, asafoetide 3kg, kelp 2kg, asarum 0.8kg, Ramulus Taxilli 1.5kg, achene of Siberian cocklebur 0.8kg, cortex albiziae 0.5kg, dracontomelon duperreanum 1kg, comospore Glochidion puberum 0.7kg, root of bidentate achyranthes 2.5kg, balloonflower root 0.8kg, Flos Ilicis Asprellae 1kg, red green onion 2.5kg, paniculate swallowwort 2kg, cockscomb 2kg, radix pseudostellariae 2kg, honey raisin tree 2kg.Extracting in water 3 times, three times amount of water be respectively equivalent to medicinal material gross weight 12 times, 8 times, 6 times, each extraction time is distinguished 3 hours, 2 hours, 1 hour, merges extract solution, filtration, and filtrate is concentrated into 70 DEG C When relative density be 1.20 clear cream, add ethanol, it is 40% to make alcohol content, stands 24 hours, and filtration, filtrate is concentrated into filtrate Relative density is 1.10 medicinal extract when being concentrated into 70 DEG C, adds starch, dextrin, and granulation, dry, whole grain produce.
The capsule of embodiment 4
Weigh root of bidentate achyranthes 4.5kg, asafoetide 3.5kg, kelp 2.5kg, asarum 1.2kg, Ramulus Taxilli 2.5kg, achene of Siberian cocklebur 1.2kg, silk tree Skin 0.8kg, dracontomelon duperreanum 1.5kg, comospore Glochidion puberum 0.9kg, root of bidentate achyranthes 3.5kg, balloonflower root 1.2kg, Flos Ilicis Asprellae 1.5kg, red green onion 3.5kg, Paniculate swallowwort 2.5kg, cockscomb 2.5kg, radix pseudostellariae 2.5kg, honey raisin tree 2.5kg.Extracted 2 times with alcohol reflux, each concentration of alcohol Respectively 80%, 60%, each ethanol consumption is respectively 10 times of medicinal material total amount, 8 times, and extraction time is respectively 4 hours, 3 hours, Merge extract solution, filtering, relative density is 1.10 medicinal extract when filtrate is concentrated into 80 DEG C, and supplementary product starch, second are added in medicinal extract Alcohol, dextrin, magnesium stearate, are made capsule according to a conventional method.
The tablet of embodiment 5
Weigh root of bidentate achyranthes 4kg, asafoetide 3.2kg, kelp 2.3kg, asarum 1kg, Ramulus Taxilli 2kg, achene of Siberian cocklebur 1kg, cortex albiziae 0.6kg, Dracontomelon duperreanum 1.2kg, comospore Glochidion puberum 0.7kg, root of bidentate achyranthes 3kg, balloonflower root 1kg, Flos Ilicis Asprellae 1.2kg, red green onion 3kg, paniculate swallowwort 2.3kg, chicken Hat flower 2.3kg, radix pseudostellariae 2.3kg, honey raisin tree 2.3kg.Extracting in water 3 times, three times amount of water be respectively 12 times of medicinal material gross weight, 8 times, 6 times, extraction time is respectively 3 hours, 2 hours, 1 hour three times, merges extract solution, filtration, when filtrate is concentrated into 70 DEG C Relative density is 1.25 clear cream, adds supplementary product starch, ethanol, talcum powder, and tablet is made.
The granule of embodiment 6
Weigh root of bidentate achyranthes 3.8kg, asafoetide 2.8kg, kelp 1.8kg, asarum 0.6kg, Ramulus Taxilli 2.3kg, achene of Siberian cocklebur 1.3kg, silk tree Skin 0.4kg, dracontomelon duperreanum 1.8kg, comospore Glochidion puberum 0.6kg, root of bidentate achyranthes 3.8kg, balloonflower root 0.6kg, Flos Ilicis Asprellae 1.8kg, red green onion 3.8kg, Paniculate swallowwort 1.8kg, cockscomb 1.8kg, radix pseudostellariae 1.8kg, honey raisin tree 1.8kg.Extracting in water 2 times, each amount of water difference are suitable 12 times, 10 times in medicinal material gross weight, each extraction time is respectively 3 hours, 2 hours, merges extract solution, is filtered, and filtrate is dense The clear cream that relative density at 80 DEG C is 1.05 is reduced to, adds ethanol, it is 70% to make alcohol content, stands 12 hours, filtration, and filtrate is dense Relative density is 1.25 medicinal extract when being reduced to 70 DEG C, adds starch, dextrin, and granulation, dry, whole grain produce.
The syrup of embodiment 7
Weigh root of bidentate achyranthes 4.2kg, asafoetide 3.8kg, kelp 2.8kg, asarum 1.4kg, Ramulus Taxilli 2.8kg, achene of Siberian cocklebur 0.6kg, silk tree Skin 0.6kg, dracontomelon duperreanum 0.9kg, comospore Glochidion puberum 0.7kg, root of bidentate achyranthes 2.8kg, balloonflower root 0.7kg, Flos Ilicis Asprellae 0.9kg, red green onion 2.8kg, Paniculate swallowwort 2.8kg, cockscomb 2.8kg, radix pseudostellariae 2.8kg, honey raisin tree 2.8kg.Extracting in water 2 times, amount of water is respectively medicine twice 10 times, 8 times of material gross weight, extraction time is respectively 2 hours, 1 hour twice, merges extract solution, filtration, and filtrate is concentrated into 80 DEG C when relative density be 1.10 medicinal extract.Syrup auxiliary material sucrose, sorbic acid, water are added in medicinal extract to stir, and sugar is made Starch agent.
The mixture of embodiment 8
Weigh root of bidentate achyranthes 3.2kg, asafoetide 3kg, kelp 1.5kg, asarum 1.3kg, Ramulus Taxilli 1.2kg, achene of Siberian cocklebur 1kg, cortex albiziae 0.7kg, dracontomelon duperreanum 1.2kg, comospore Glochidion puberum 0.9kg, root of bidentate achyranthes 3.2kg, balloonflower root 0.9kg, Flos Ilicis Asprellae 1.2kg, red green onion 3.2kg, Xu Long minister in ancient times 1.5kg, cockscomb 1.5kg, radix pseudostellariae 1.5kg, honey raisin tree 1.5kg.Extracting in water 3 times, amount of water is respectively equivalent to three times 12 times, 8 times, 6 times of medicinal material gross weight, each extraction time are distinguished 3 hours, 2 hours, 1 hour, merge extract solution, filter, filter Liquid concentration ad pond om is 3 times of medicinal material gross weight, filling, adds mixture auxiliary material sucrose, ethyl ester, water, sorbic acid and stirs, Mixture is made.
The pulvis of embodiment 9
Weigh root of bidentate achyranthes 3kg, asafoetide 2.8kg, kelp 3kg, asarum 1.2kg, Ramulus Taxilli 2kg, achene of Siberian cocklebur 1.2kg, cortex albiziae 0.5kg, dracontomelon duperreanum 1.8kg, comospore Glochidion puberum 0.8kg, root of bidentate achyranthes 2.2kg, balloonflower root 1.4kg, Flos Ilicis Asprellae 1.8kg, red green onion 2.2kg, Xu Long minister in ancient times 3kg, cockscomb 3kg, radix pseudostellariae 3kg, honey raisin tree 3kg.Crush, sieving, produce.
Embodiment 10
Granule prepared by the embodiment of the present invention 6, it is oral to give patients with secretory otitis media, 1 bag every time, 3 times a day, clinical Data are as follows:
Disorder class Illness number of cases The course of disease Treatment time Efficiently individual quantity Total effective rate
Secretory otitis media 89 7 days-October 5-15 days 78 people 87.6%
Embodiment 11
Zhang, female, 26 years old, main suit's ears suffocation companion Hearing 1 day.It is vexed that patient ears occurred before 1 day after the infection of the upper respiratory tract Stifled sense, companion's Hearing, intermittent low-key tinnitus, in roar, slight otalgia.Heating, facial paralysis, dizziness, nausea are not told and are vomitted The symptom such as tell.For secretory otitis media(Bilateral), acute upper respiratory infection.The embodiment of the present invention 1 is given to treat, it is multiple after 3 days When examining, patients symptomatic relief.Although above the present invention is made with general explanation, embodiment and experiment Description in detail, but on the basis of the present invention, it can be made some modifications or improvements, this is to those skilled in the art Obviously.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belonging to the present invention will Seek the scope of protection.

Claims (7)

1. a kind of Chinese medicine composition for treating secretory otitis media, it is characterised in that it is the raw material system by including following parts by weight Into:
Root of bidentate achyranthes 30-50 parts, asafoetide 25-40 parts, kelp 15-30 parts, asarum 5-15 parts, Ramulus Taxilli 10-30 parts, achene of Siberian cocklebur 5-15 Part, cortex albiziae 3-10 parts, dracontomelon duperreanum 8-20 parts, comospore Glochidion puberum 5-10 parts, root of bidentate achyranthes 20-40 parts, balloonflower root 5-15 parts, Flos Ilicis Asprellae 8-20 Part, red green onion 20-40 parts, paniculate swallowwort 15-30 parts, cockscomb 15-30 parts, radix pseudostellariae 15-30 parts, honey raisin tree 15-30 parts.
2. the Chinese medicine composition for the treatment of secretory otitis media as claimed in claim 1, it is characterised in that it is by including following Made of the raw material of parts by weight:
Root of bidentate achyranthes 35-45 parts, asafoetide 30-35 parts, kelp 20-25 parts, asarum 8-12 parts, Ramulus Taxilli 15-25 parts, achene of Siberian cocklebur 8-12 Part, cortex albiziae 5-8 parts, dracontomelon duperreanum 10-15 parts, comospore Glochidion puberum 7-9 parts, root of bidentate achyranthes 25-35 parts, balloonflower root 8-12 parts, Flos Ilicis Asprellae 10-15 Part, red green onion 25-35 parts, paniculate swallowwort 20-25 parts, cockscomb 20-25 parts, radix pseudostellariae 20-25 parts, honey raisin tree 20-25 parts.
3. the Chinese medicine composition for the treatment of secretory otitis media as claimed in claim 1 or 2, it is characterised in that its active component It is to be prepared using the extraction of the ethanol of water extraction or 40-80% concentration expressed in percentage by volumes.
4. the Chinese medicine composition for the treatment of secretory otitis media as claimed in claim 3, it is characterised in that its active component is It is prepared by the following method:Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is total equivalent to medicinal material 6-12 times of weight, each extraction time are 1-3 hours, merge extract solution, filtration, filtrate is concentrated into relatively close at 70-80 DEG C The clear cream for 1.15-1.20 is spent, produces active component.
5. the Chinese medicine composition for the treatment of secretory otitis media as claimed in claim 3, it is characterised in that its active component is It is prepared by the following method:Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs after mixing, each ethanol is used Measure as 4-10 times of medicinal material total amount, extraction time is 1-4 hours, merges extract solution, filtering, and filtrate is concentrated into 70-80 DEG C of phase To the clear cream that density is 1.15-1.20, active component is produced.
6. the Chinese medicine composition for the treatment of secretory otitis media as claimed in claim 3, it is characterised in that its active component It is prepared by the following method and forms:Whole medicinal materials are taken, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material 6-12 times of gross weight, each extraction time are 1-3 hours, merge extract solution, filtration, filtrate is concentrated into relative at 70-80 DEG C Density is 1.15-1.20 clear cream, adds ethanol, and it is 40-70% to make alcohol content, stands 12-24 hours, and filtration, filtrate is concentrated into Relative density is 1.10-1.25 medicinal extract at 70-80 DEG C, produces active component.
A kind of 7. Chinese medicine composition for treating secretory otitis media, as the treatment secretory otitis media described in claim 1 or 2 Chinese medicine composition is prepared with pharmaceutically acceptable carrier combination.
CN201711281919.2A 2017-12-07 2017-12-07 A kind of Chinese medicine composition for treating secretory otitis media and preparation method thereof Pending CN107737206A (en)

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