CN102085313A - Composition with cough-relieving effect - Google Patents

Abstract

The invention discloses a composition with a cough-relieving effect, which is prepared from the raw medicinal materials including 10-15 parts of loguat leaf, 10-15 parts of unibract fritillary bulb, 5-10 parts of dried tangerine or orange peel, 5-10 parts of platycodon root, 5-10 parts of bamboo shavings, 2-5 parts of glehnia root, 2-5 parts of snakegourd seed, 2-5 parts of polygala root and 2-5 parts of liquorice. The composition is prepared by reasonably matching and combining different herbal medicines and has an obvious cough-relieving effect and good safety.

Description

A kind of compositions with antitussive action

Technical field

The present invention relates to the pharmaceutical preparations technology field, especially a kind of compositions with antitussive action.

Background technology

The human immune system has three kinds of defencive functions:

1. defense function: the pathogenic microorganism invasion and attack of opposing antibacterial, virus, fungus etc.

2. stabilization function: in time remove dead cell old and feeble in the body,, thereby keep intravital stable with the performance of obstruction free body normal function.

3. immune surveillance function: in time find and eliminate the cell that morphs in the body, prevent the generation of cancer.

Immunologic dysfunction comprises the hyperfunction and immunologic hypofunction of immunologic function.

So-called immunologic hypofunction is exactly that a variety of causes makes immune system normally not bring into play protective effect, in the case, very easily causes infection such as antibacterial, virus, fungus, and various diseases takes place, even causes tumor.

The typical clinical manifestation of immunologic hypofunction is easily various serious infection to take place repeatedly because of losing immune surveillance function, as upper respiratory tract infection, and urinary tract infection, septicemia, meningitis, chickenpox, measles, pulmonary tuberculosis etc.

In addition, opportunistic infection is the characteristic performance of immunologic hypofunction.The toxicity of most of antibacterials, virus, fungus is lower, can not make the normal person ill, but because the patient immune function who has reduction, these hypotoxicity antibacterials, virus, fungus also can infect body, cause disease, thisly be reduced to the infection of condition, be called opportunistic infection by medical circle with immunologic function.The common skin of the patient of opportunistic infection, mucosa, gastrointestinal tract candida albicans infection.Due to illness the people often infects, and has strengthened the consumption of body, so generally have a delicate constitution, performance such as malnutrition, listlessness, fatigue and weak, appetite depression, sleep disorder.Serious immunologic hypofunction person is arranged, behind inoculation attenuation challenge virus or antibacterial vaccine, can cause serious opportunistic infection, even cause that causing gangrenosum acne reacts.

At present, control immunologic hypofunction, the particularly key of Secondary cases immunologic hypofunction is the function that improves immunocyte.The medicine of cough-relieving power commonly used adopts genetic engineering to produce more at present, and the production cost height costs an arm and a leg, unsuitable life-time service.The Lac regis apis that can often take during even expert advice keeps healthy usually, fish zamene, Oleum Bulbus Allii, lecithin, Radix Panacis Quinquefolii etc., all price is high, and for the immunologic hypofunction patient that needs are often taken, its financial burden is also well imagined.

Summary of the invention

Main purpose of the present invention just provides a kind of compositions with antitussive action safe and effective and with low cost.

In order to realize the foregoing invention purpose, the technical solution used in the present invention is as follows:

A kind of compositions with antitussive action, make with following amount amount part proportion raw material medicine:

Folium Eriobotryae 10-15 part, Bulbus Fritillariae Cirrhosae 10-15 part, Pericarpium Citri Reticulatae 5-10 part, Radix Platycodonis 5-10 part, Caulis Bambusae In Taenia 5-10 part, Radix Glehniae 2-5 part, Semen Trichosanthis 2-5 part, Radix Polygalae 2-5 part, Radix Glycyrrhizae 2-5 part.

The crude drug proportioning of above-mentioned composition can be preferably:

Folium Eriobotryae 12-15 part, Bulbus Fritillariae Cirrhosae 10-12 part, Pericarpium Citri Reticulatae 8-10 part, Radix Platycodonis 8-10 part, Caulis Bambusae In Taenia 5-8 part, Radix Glehniae 2-4 part, Semen Trichosanthis 2-4 part, Radix Polygalae 2-4 part, Radix Glycyrrhizae 3-5 part.

Medicine of the present invention can be according to the conventional preparation method preparation of various peroral dosage form medicines.

In each crude drug of the present composition:

Folium Eriobotryae is the dried leaves of dicotyledon Rosaceae Rosaceae Folium Eriobotryae Eriobotrya japonica (Thunb.) Lindl..Contain compositions such as amygdalin (amygdalin), ursolic acid, oleanolic acid, vitamin B1 and C, tannin, organic acid, saccharide.Effect with clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI; Cure mainly cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastropyretic vomiting, hiccup.

Bulbus Fritillariae Cirrhosae is the dry bulb of Liliaceae (Liliaceae) Bulbus Fritillariae Cirrhosae Fritilla riacirrhosa D.Don, dark violet Bulbus Fritillariae Uninbracteatae Fritillaria unibracteata Hsiao et K.C.Hsia, Gansu Bulbus Fritillariae Uninbracteatae Fritillaria przewalskii Maxim. or Bulbus Fritillariae cirrhosae Fritillaria delavayi Ftanch..Former three is practised title " loose shellfish " and " blue or green shellfish " respectively by the character difference, and the latter practises title " lubei ".Commodity Bulbus Fritillariae Cirrhosae contains Bulbus Fritillariae Uninbracteatae third element (Fritimine), and the Gansu Bulbus Fritillariae Uninbracteatae contains Min shellfish alkali (Minpeimine) and the Min shellfish is divided alkali (Minpeiminine), chinpeimine (Chinpeimine), and lubei contains lu pei alkali (Fritiminine).Effect with clearing heat and moistening lung, preventing phlegm from forming and stopping coughing; Be used for lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.

Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Medical material is divided into " Pericarpium Citri Reticulatae " and " Pericarpium citri reticuatae chachiensis ".Mainly contain Hesperidin (C ₂₈H ₃₄O ₁₅).Have regulate the flow of vital energy, transfer in, dampness, clears phlegm; Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia, abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in the turbid damp resistance, phlegm-damp is stopped up the cough and asthma of lung.

Radix Platycodonis is the root of dicotyledon campanulaceae Radix Platycodonis Platycodon grandiflorum (Jacq.) A.DC..Contain platycodoside C, kikyosaponin D, hitodesterol, hitodesterol-β-D-glycoside, Betula platyphylla Suk. ester alcohol, triterpene material platycogenic acid A, B, C, and composition such as platycodonin, inulin.The energy expelling phlegm for arresting cough, and lung qi dispersing, evacuation of pus effect are arranged; Cure mainly: cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, uroschesis.

Caulis Bambusae In Taenia is the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro Bambusa tuldoides Munro, major part allusion quotation bamboo Sinocalamus beecheyanus (Munro) Mc-Clure var.pubescens P.F.Li or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle Phyllostachys nigra (Lodd.) Munro var.henonis (Mitf.) Stapf ex Rendle.Contain lignin, cellulose.The effect that have removing heat-phlegm, relieves restlessness and prevents vomiting; Being used for phlegm-heat cough, gallbladder fire holds expectorant, dysphoria with smothery sensation vomiting, palpitation with fear under the arm and loses eye, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.

Radix Glehniae is the root of samphire glehnia littoralis Glehnia littoralis Fr.schmidt ex Miq..Contain imperatorin (imperatorin), psoralen (psoralen).Bergapten, circle angelica lactone-7-0-β-gentiobioside (multiple coumarin such as oosthenol-7-0-β-gentio-bioside), and contain alkaloid, starch, trace volatilization wet goods.Effect with nourishing YIN and clearing away lung-heat, reinforcing stomach reg fluid; It is thirsty to be used for lung-heat type cough, chronic cough expectorant blood, calentura Tianjin wound.

Semen Trichosanthis is the seed of cucurbitaceous plant Fructus Trichosanthis or trichosanthes rosthornii Harms, big sub-Fructus Trichosanthis etc.Contain glycoside, Saponin, organic acid and its esters (as calcium oxalate), natural gum, resin, fatty oil and pigment etc.; Fatty oil contains rate and is about 26%, and wherein satisfied fatty acid accounts for 30%, and unsaturated person accounts for 66.5%; Unsaturated fatty acid is based on trichosanic acid.Have lung moistening, reduce phlegm, the effect of laxation; Control phlegm-heat cough, the dryness accumulated in the stomach and intestine constipation, carbuncle, breast is few.

Radix Polygalae is the dry root of milk wort Radix Polygalae Polygala tenuifolia Willd. or ovum leaf Radix Polygalae Polygala sibirica L..The effect of have the Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling; Be used for that insomnia and dreamful sleep, forgetful palpitation with fear, staring spells, expectoration that disarmony between the heart and kidney causes are not well, sore swollen toxin, breast swell and pain.

Radix Glycyrrhizae is dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. G.inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G.glabra L..Have effects such as invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.But be usually used in the anxious pain of weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, and cushion toxicity and strong.

Compared with prior art, the invention has the beneficial effects as follows: the present composition is reasonably combined by different pharmaceutical, and antitussive action is obvious, and safety is good.

The specific embodiment

The present invention is described in further detail below in conjunction with the specific embodiment.

Embodiment 1

Present embodiment has the compositions of antitussive action and makes with following amount amount part proportion raw material medicine:

10 parts of Folium Eriobotryaes, 10 parts of Bulbus Fritillariae Cirrhosaes, 10 parts of Pericarpium Citri Reticulataes, 8 parts of Radix Platycodoniss, 8 parts of Caulis Bambusae In Taenia, 5 parts of Radix Glehniaes, 4 parts of Semen Trichosanthis, 4 parts of Radix Polygalaes, 2 parts in Radix Glycyrrhizae.

Embodiment 2

Present embodiment has the compositions of antitussive action and makes with following amount amount part proportion raw material medicine:

15 parts of Folium Eriobotryaes, 12 parts of Bulbus Fritillariae Cirrhosaes, 5 parts of Pericarpium Citri Reticulataes, 10 parts of Radix Platycodoniss, 10 parts of Caulis Bambusae In Taenia, 2 parts of Radix Glehniaes, 5 parts of Semen Trichosanthis, 2 parts of Radix Polygalaes, 3 parts in Radix Glycyrrhizae.

Embodiment 3

Present embodiment has the compositions of antitussive action and makes with following amount amount part proportion raw material medicine:

12 parts of Folium Eriobotryaes, 15 parts of Bulbus Fritillariae Cirrhosaes, 8 parts of Pericarpium Citri Reticulataes, 5 parts of Radix Platycodoniss, 5 parts of Caulis Bambusae In Taenia, 4 parts of Radix Glehniaes, 2 parts of Semen Trichosanthis, 5 parts of Radix Polygalaes, 5 parts in Radix Glycyrrhizae.

The various embodiments described above medicine is all by following method preparation: the crude drug of getting described ratio mixes, and adds 12 times of water boiling and extraction 2 hours, filters filtrate for later use; Filtering residue added 10 times of water boiling and extraction 2 hours again, filtered; Merge filtrate twice, be concentrated into about 1.10 (60 ℃) of relative density, adding starch is an amount of, and the back tabletting of granulating is made tablet, promptly.

Claims (2)

1. compositions with antitussive action, make with following amount amount part proportion raw material medicine:

Folium Eriobotryae 10-15 part, Bulbus Fritillariae Cirrhosae 10-15 part, Pericarpium Citri Reticulatae 5-10 part, Radix Platycodonis 5-10 part, Caulis Bambusae In Taenia 5-10 part, Radix Glehniae 2-5 part, Semen Trichosanthis 2-5 part, Radix Polygalae 2-5 part, Radix Glycyrrhizae 2-5 part.

2. compositions according to claim 1 is characterized in that: amount amount part proportioning of described crude drug is:

Folium Eriobotryae 12-15 part, Bulbus Fritillariae Cirrhosae 10-12 part, Pericarpium Citri Reticulatae 8-10 part, Radix Platycodonis 8-10 part, Caulis Bambusae In Taenia 5-8 part, Radix Glehniae 2-4 part, Semen Trichosanthis 2-4 part, Radix Polygalae 2-4 part, Radix Glycyrrhizae 3-5 part.