CN101450172A - Traditional Chinese medicine preparation for treating cough - Google Patents
Traditional Chinese medicine preparation for treating cough Download PDFInfo
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- CN101450172A CN101450172A CNA2007101505395A CN200710150539A CN101450172A CN 101450172 A CN101450172 A CN 101450172A CN A2007101505395 A CNA2007101505395 A CN A2007101505395A CN 200710150539 A CN200710150539 A CN 200710150539A CN 101450172 A CN101450172 A CN 101450172A
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Abstract
The invention discloses a Chinese herbal medicament for treating cough, which is characterized in being made from: radix peucedani 10-20%, white peony root 10-20%, Tuber of Dwarf Lilyturf 5-18%, cortex mori 20-30%, almond 10-20% and uncooked licorice 5-10%. The preparation method comprises: A, grinding the Tuber of Dwarf Lilyturf and half of the white peony root into fine powder, sieving and well mixing; B, decocting the rest medicines by water for three times, in which, the water amount is 10 times, 8 times and 6 times of the medicine amount, and the time is 2 hours, 1 hour and 0.5 hour; C, combining the decoctions, filtering and concentrating the filtrate to the relative density of 1.25-1.30 measured under the temperature of 60 degrees centigrade; D, adding the above fine powder, mixing well and drying under low temperature less than 60 degrees centigrade; E, grinding into fine powder of 80-120mu, sieving, well mixing and making into capsules. The Chinese herbal medicament for treating cough of the invention adopts locally common Chinese herbal medicament as raw material, has a low cost, achieves functions of relieving cough and removing phlegm, and good treatment effect, is suitable for patient in different ages suffered from cough caused by respiratory tract infection and cold.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, relate to a kind of Chinese medicine preparation for the treatment of cough and preparation method thereof.
Background technology
Influenza is the acute respiratory infectious disease that is caused by influenza virus.Virus is present in patient's the respiratory tract, gives others through droplet infection when patient's cough, sneeze.The infectiousness of influenza is very strong, because this virus makes a variation easily, even suffered from the people of influenza, meets influenza pandemic again when next time, and he still can infect, so influenza causes that easily fulminant is popular.Generally more in the popular chance of winter-spring season, have 20～40% people at every turn and can infect influenza.These viruses are present in patient's the respiratory tract, give others through droplet infection.Common cold wants much weak than the influenza infectiousness, common people suffer from cold, drench with rain, overtired after, because of resistance descends, just fall ill easily.So common cold occurs individually often, seldom resemble influenza when popular, patient occurs in batch.In common cold when morbidity,, majority is a low grade fever, hyperpyrexia seldom, patient have a stuffy nose watery nasal discharge, have sore throat, headache, systemic pain, fatigue and weak, cough.No matter be common cold or influenza, the patient causes cough at last easily, and the cough that wherein has can reach outbreak repeatedly in 1-2 month, is difficult to cure.Cough is the cardinal symptom of respiratory system disease, is dry cough seldom as cough but no phlegm or amount of expectoration, is common in acute pharyngolaryngitis, bronchitic initial stage; Foreign body in the bronchus is more common in the acute cough that takes place suddenly; Long-term chronic cough is more common in chronic bronchitis, pulmonary tuberculosis etc.The detrimental effect of cough is to be diffused into contiguous bronchia to the trachea pathological changes, aggravates disease.In addition, lasting violent cough can influence rest, goes back easy consumption muscle power, and can cause the destruction of alveolar wall Elastic tissue, brings out emphysema.
Summary of the invention
The objective of the invention is to, a kind of Chinese medicine preparation of treatment cough of pure Chinese medicine is provided, it is to be made by the herbal raw material of following weight percentage ratio: Radix Peucedani 10-20%, Radix Paeoniae Alba 10-20%, Radix Ophiopogonis 5-18%, Cortex Mori 20-30%, Semen Armeniacae Amarum 10-20%, Radix Glycyrrhizae 5-10%.
The present invention preferably treats the Chinese medicine preparation of cough, and it is made by following weight percentages: Radix Peucedani 13.35%, the Radix Paeoniae Alba 13.35%, Radix Ophiopogonis 16.55%, Cortex Mori 26.65%, Semen Armeniacae Amarum 12%, Radix Glycyrrhizae 8%.
The method of the Chinese medicine preparation of treatment of the present invention cough, it is characterized in that comprising the steps: A, with Radix Ophiopogonis with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve mixing; B, surplus medicine decoct with water three times, and 2-4 hour for the first time, 1-3 hour for the second time, 0.5 hour for the third time; C, collecting decoction filter, and filtrate is concentrated into relative density and is 1.25-1.30 down at 60 ℃; D, add above-mentioned fine powder, mixing, cold drying; E, be ground into fine powder, sieve, mixing, promptly encapsulated.
The further preparation method of the present invention, comprise the steps: A, with Radix Ophiopogonis with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve, mixing, standby; B, surplus medicine decoct with water three times, and amount of water is respectively 10 times, 8 times, 6 times, and decocting time is 2 hours, and 1 hour, 0.5 hour; C, collecting decoction filter, and filtrate is concentrated into relative density and is 1.25-1.30 60 ℃ of hot down surveys; D, the above-mentioned standby fine powder of adding, mixing, cold drying below 60 ℃; E, be ground into 80-120 purpose fine powder, sieve, mixing, promptly encapsulated.
The Chinese medicine preparation of treatment cough of the present invention is characterized in that described preparation comprises: conventional tablet, dispersible tablet, oral cavity disintegration tablet, effervescent tablet, chewable tablet, enteric coatel tablets, capsule, granule or enteric coated capsule, preferred capsule preparations.
The Chinese medicine preparation of treatment cough of the present invention is characterized in that described pharmaceutic adjuvant adjuvant comprises: filler, binding agent, disintegrating agent, lubricant, correctives or aromatic.
The Chinese medicine preparation of treatment cough of the present invention is characterized in that described filler comprises: xylitol, dextrin, starch, pregelatinized Starch, mannitol or microcrystalline Cellulose; Described binding agent comprises starch, polyvidone, hypromellose, hyprolose, Polyethylene Glycol, medicinal alcohol or water; Described disintegrating agent comprises starch, low-substituted hydroxypropyl cellulose or carmethose.
The physicochemical property of the Chinese crude drug that the present invention is selected is as follows:
Radix Peucedani: dispelling wind-heat, the therapeutic method to keep the adverse QI flowing downwards, expectorant.Control headache due to pathogenic wind-heat, the expectorant heat syndrome cough is breathed heavily, vomiting, and chest and diaphragm is full vexed.
Be used as medicine with tuber Radix Ophiopogonis.Nature,taste and action: sweet, little hardship, cold, Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, relieving restlessness clears away heart-fire.Cure mainly consumption of body fluid caused by febrile disease, vexed, thirsty, dry pharynx lung-heat, cough, pulmonary tuberculosis.
The Radix Paeoniae Alba: Radix Paeoniae Alba root contains paeoniflorin (paeoniflorin), oxypaeoniflorin (oxypaeoniflorin), peony lactone glycoside (albiflorin), benzoylpaeoniflorin (benzoylpaeoniflorin), paeoniflorin unit ketone (paeoniflorigenone), the former glycoside of paeonol (paeonolide), paeonol (paeonol); Still contain
Benzoic acid, daucosterol and multiple tannin class etc.The suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Be used for
It is dizzy to have a headache, hypochondriac pain,
Stomachache, limb pain twin, blood deficiency and yellow complexion,
Menoxenia, spontaneous perspiration, night sweat.
Cortex Mori contains umbelliferone, scopoletin, flavone component Morusin, Sang Suo, mulberrochromene, cyclomulberrin, cyclomulberrochromene etc.Has the sending down the abnormal ascending QI relieving cough and asthma, inducing diuresis to remove edema, loosening bowel to relieve constipation.Be used for cough and asthma, fullness in the chest abundant expectoration, withered, the dryness of the intestine constipation in blood deficiency Tianjin.
Semen Armeniacae Amarum: contain abundant fatty oil, the effect of cholesterol reducing is arranged, Semen Armeniacae Amarum has good effect to the control cardiovascular system diseases; The Chinese medicine theory thinks that Semen Armeniacae Amarum has the effect of promoting the production of body fluid to quench thirst, lung moistening Dingchuan, is usually used in the dryness of the lung patient's health care and treatment such as breath with cough.
Radix Glycyrrhizae: contain triterpene soap building site glycyrrhizic acid, i.e. glycyrrhizin, enoxolone.Still contain liquiritin, mannitol, malic acid, agedoite, volatile oil, estrogenic chemicals etc.Have heat-clearing and toxic substances removing, relieving cough and resolving phlegm, by the spleen stomach function regulating, the function of coordinating the actions of various ingredients in a prescription.All weakness of the spleen and stomach, deficiency of QI in middle-JIAO, shortness of breath and fatigue, anorexia and loose stool, cough, asthma, skin sore, gastral cavity abdomen contraction is anxious has a pain, but all compatibility is used.
The Chinese medicine preparation of treatment cough of the present invention, it adopts comparatively in the localities Chinese medicinal herbses of seeing as raw material more, and is with low cost.The function of relieving cough and expelling phlegm and better therapeutic effect are arranged, and the present invention has the cure rate height, instant effect, taking convenience, advantage such as without any side effects.Be suitable for all ages and classes by respiratory tract infection and the cough that causes of flu, it is short that it begins onset time, average out to 1.6 days, effective percentage reaches 95%, cures and obvious effective rate is 84%.
The Chinese medicine preparation of the treatment cough of the present invention's development has carried out clinical trial to 100 flu patients, and wherein the cough cure rate that causes after the flu reaches 95%, and model case is as follows:
(1) patient's sex: male patient age: 59 years old, the detailed state of an illness and consulting purpose: flu, rhinorrhea brought up phlegm when one coughs but do not have a fever.Fast two weeks, but pulmonary does not infect.Drank JIZHI TANGJIANG (a bottle), powerful Pi fragrant plant reveals (one bottle), eats compound recipe Rhizoma Seu Herba Bergeniae sheet (a bottle), has beaten two Zhi Aluo former times Weis.But also do not have now.Cough still.Take the capsule of the treatment cough of the present invention's development, every day 3 times, each 2, coughing after 3 days obviously alleviates, week back symptom complete obiteration.
(2) patient's sex: women patient age: 40 years old, the detailed state of an illness and consulting purpose: flu was 7 days on the future trouble of going on business, and wind and cold is violated lung, Lung Qi obstraction, card is seen cough, and thin white phlegm is with headache, nasal obstruction, snivel, itching of the throat is low voice speaking, and joint is ached, cold and heat are lossless, thin white fur of tongue, floating pulse.Drink cough mixture (a bottle), ate pioneer IV number, beaten ammonium Bian penicillin, but still the nocturnal cough, take the capsule of the treatment cough of the present invention's development, every day 3 times, each 2, coughing after 3 days obviously alleviates, week back symptom complete obiteration.
(3) patient's sex: women patient age: 8 years old, the in detail state of an illness and consulting purpose: child caught a cold and fully recovers substantially after a week, but has no temperature now, just nasal obstruction coughs difficultly, and the expectorant sound is arranged, taking nourishing YIN and clearing away lung-heat and Radix Glycyrrhizae tabellae at present, but poor effect, the nocturnal cough sees heavily, changes the capsule of the treatment cough of clothes the present invention development, every day 3 times, each 1, coughing after 3 days obviously alleviates, week back symptom complete obiteration.
(4) patient's sex: women patient age: 30 years old, the in detail state of an illness and consulting purpose: suffered from cold because of heavy rain is drenching excessively in 30 years old, and cause more than the fever 39oC, it was big to cough, tell the yellow sputum amount, takes one week of Roxithromycin, sx, but the nocturnal cough is still very heavy.Oral capsule of the present invention is after 1 course of treatment, and the nocturnal cough takes a turn for the better, and after obeying 3 courses of treatment, coughs, expectorant all eliminates.
The specific embodiment
Embodiment 1
Form: Radix Peucedani 10g, Radix Paeoniae Alba 10g, Radix Ophiopogonis 5g, Cortex Mori 20g, Semen Armeniacae Amarum 10g, Radix Glycyrrhizae 5g.Preparation method: A, with Radix Ophiopogonis with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve mixing; B, surplus medicine decoct with water three times, and 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time; C, collecting decoction filter, and it is 1.25 under 60 ℃ that filtrate is concentrated into relative density; D, add above-mentioned fine powder, add xylitol 2g again, mixing, cold drying; E, be ground into fine powder, sieve, mixing, promptly encapsulated.
Embodiment 2
Form: Radix Peucedani 20g, Radix Paeoniae Alba 5g, Radix Ophiopogonis 18g, Cortex Mori 30g, Semen Armeniacae Amarum 20g, Radix Glycyrrhizae 10g.Preparation method: A, with Radix Ophiopogonis with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve, mixing, standby; B, surplus medicine decoct with water three times, and amount of water is respectively 10 times, 8 times, 6 times, and decocting time is 2 hours, and 1 hour, 0.5 hour; C, collecting decoction filter, and it is 1.30 60 ℃ of hot down surveys that filtrate is concentrated into relative density; D, the above-mentioned standby fine powder of adding add xylitol 2g, mixing, cold drying below 60 ℃ again; E, be ground into 80 purpose fine powders, sieve, mixing, promptly encapsulated.
Embodiment 3
Form: Radix Peucedani 13.35g, Radix Paeoniae Alba 13.35g, Radix Ophiopogonis 16.55g, Cortex Mori 26.65g, Semen Armeniacae Amarum 12g, Radix Glycyrrhizae 8g.Preparation method: A, with Radix Ophiopogonis with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve, mixing, standby; B, surplus medicine decoct with water three times, and amount of water is respectively 10 times, 8 times, 6 times, and decocting time is 2 hours, and 1 hour, 0.5 hour; C, collecting decoction filter, and it is 1.30 60 ℃ of hot down surveys that filtrate is concentrated into relative density; D, the above-mentioned standby fine powder of adding add xylitol 2g, mixing, cold drying below 60 ℃ again; E, be ground into 80 purpose fine powders, sieve, mixing, promptly encapsulated.
Embodiment 4
Form: Radix Peucedani 15g, Radix Paeoniae Alba 15g, Radix Ophiopogonis 18g, Cortex Mori 23g, Semen Armeniacae Amarum 18g, Radix Glycyrrhizae 10g.Preparation method: A, with Radix Ophiopogonis with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve mixing; B, surplus medicine decoct with water three times, and 4 hours for the first time, 3 hours for the second time, 0.5 hour for the third time; C, collecting decoction filter, and it is 1.30 under 60 ℃ that filtrate is concentrated into relative density; D, add above-mentioned fine powder, add xylitol 2g again, mixing, cold drying; E, be ground into fine powder, sieve, mixing, promptly encapsulated.
Embodiment 5,
1, prescription is formed: Radix Peucedani 15g, Radix Paeoniae Alba 15g, Radix Ophiopogonis 18g, Cortex Mori 23g, Semen Armeniacae Amarum 18g, Radix Glycyrrhizae 10g.Preparation method:
2, method for making: A, with Radix Ophiopogonis with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve mixing; B, surplus medicine decoct with water three times, and 4 hours for the first time, 3 hours for the second time, 0.5 hour for the third time; C, collecting decoction filter, and it is 1.30 under 60 ℃ that filtrate is concentrated into relative density; D, add above-mentioned fine powder, add xylitol 2g again, mixing, cold drying; E, be ground into fine powder, sieve,
1) get substrate 33.0 gram, polyethylene glycol 6000,18.3 grams, Macrogol 4000,2.4 gram glycerol are put in the container, are heated to 90 ℃ in water-bath, treat whole fusions after, add fine powder 21.5 grams, be stirred to dissolving, evenly;
2) drip system: the medicinal liquid for preparing is transferred in the reservoir, and airtight and insulation is at 90 ℃, and regulator solution titer valve splashes in 15～40 ℃ the methyl-silicone oil;
3) drying: with the drop pill drop that forms to the greatest extent and wipe methyl-silicone oil, drying, promptly.
Although the present invention has done detailed description in conjunction with its special embodiment, clearly concerning the skilled people in present technique field, still can make various changes and improvements, can not depart from spirit of the present invention and protection domain.
Claims (7)
1, a kind of Chinese medicine preparation for the treatment of cough is characterized in that, it is made by the following weight percentages Chinese herbal medicine: Radix Peucedani 10-20%, Radix Paeoniae Alba 10-20%, Radix Ophiopogonis 5-18%, Cortex Mori 20-30%, Semen Armeniacae Amarum 10-20%, Radix Glycyrrhizae 5-10%.
2, the Chinese medicine preparation of treatment as claimed in claim 1 cough is characterized in that it is made by following weight percentages: Radix Peucedani 13.35%, the Radix Paeoniae Alba 13.35%, Radix Ophiopogonis 16.55%, Cortex Mori 26.65%, Semen Armeniacae Amarum 12%, Radix Glycyrrhizae 8%.
3, the Chinese medicine preparation of treatment cough as claimed in claim 1 is characterized in that described preparation comprises: conventional tablet, dispersible tablet, oral cavity disintegration tablet, effervescent tablet, chewable tablet, enteric coatel tablets, capsule, granule or enteric coated capsule.
4, the Chinese medicine preparation of treatment cough as claimed in claim 1 is characterized in that described pharmaceutic adjuvant adjuvant comprises: filler, binding agent, disintegrating agent, lubricant, correctives or aromatic.
5, the Chinese medicine preparation of treatment cough as claimed in claim 1 is characterized in that described filler comprises: xylitol, dextrin, starch, pregelatinized Starch, mannitol or microcrystalline Cellulose; Described binding agent comprises starch, polyvidone, hypromellose, hyprolose, Polyethylene Glycol, medicinal alcohol or water; Described disintegrating agent comprises starch, low-substituted hydroxypropyl cellulose or carmethose.
6, a kind of method for preparing the Chinese medicine preparation of claim 1 or 2 described treatments cough, it is characterized in that comprising the steps: A, with Radix Ophiopogonis with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve mixing; B, surplus medicine decoct with water three times, and 2-4 hour for the first time, 1-3 hour for the second time, 0.5 hour for the third time; C, collecting decoction filter, and filtrate is concentrated into relative density and is 1.25-1.30 down at 60 ℃; D, add above-mentioned fine powder, mixing, cold drying; E, be ground into fine powder, sieve, mixing, promptly encapsulated.
7, preparation method according to claim 1 and 2, it is characterized in that comprising the steps: A, with Radix Ophiopogonis with partly measure the Radix Paeoniae Alba and be ground into fine powder, sieve, mixing, standby; B, surplus medicine decoct with water three times, and amount of water is respectively 10 times, 8 times, 6 times, and decocting time is 2 hours, and 1 hour, 0.5 hour; C, collecting decoction filter, and filtrate is concentrated into relative density and is 1.25-1.30 60 ℃ of hot down surveys; D, the above-mentioned standby fine powder of adding, mixing, cold drying below 60 ℃; E, be ground into 80-120 purpose fine powder, sieve, mixing, promptly encapsulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101505395A CN101450172A (en) | 2007-11-28 | 2007-11-28 | Traditional Chinese medicine preparation for treating cough |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101505395A CN101450172A (en) | 2007-11-28 | 2007-11-28 | Traditional Chinese medicine preparation for treating cough |
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| CN101450172A true CN101450172A (en) | 2009-06-10 |
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| CNA2007101505395A Pending CN101450172A (en) | 2007-11-28 | 2007-11-28 | Traditional Chinese medicine preparation for treating cough |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535156A (en) * | 2016-01-05 | 2016-05-04 | 邱钱勇 | Traditional Chinese medicine preparation for treating coughs and preparation method and application thereof |
-
2007
- 2007-11-28 CN CNA2007101505395A patent/CN101450172A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535156A (en) * | 2016-01-05 | 2016-05-04 | 邱钱勇 | Traditional Chinese medicine preparation for treating coughs and preparation method and application thereof |
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Open date: 20090610 |