CN109645390A - A kind of matrimony vine capsule and preparation method thereof improved the immunity of the human body - Google Patents
A kind of matrimony vine capsule and preparation method thereof improved the immunity of the human body Download PDFInfo
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- CN109645390A CN109645390A CN201811517022.XA CN201811517022A CN109645390A CN 109645390 A CN109645390 A CN 109645390A CN 201811517022 A CN201811517022 A CN 201811517022A CN 109645390 A CN109645390 A CN 109645390A
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- China
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- immunity
- human body
- sodium alginate
- matrimony vine
- capsule
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Classifications
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The present invention relates to a kind of matrimony vine capsules and preparation method thereof improved the immunity of the human body, the matrimony vine capsule improved the immunity of the human body of the invention, including capsule shells and capsule base, capsule base includes that cladding improves the immunity of the human body the sodium alginate micro ball of composition and the chitosan being coated on outside sodium alginate micro ball；Improving the immunity of the human body composition includes fructus lycii fine powder, ganoderma lucidum polysaccharide, multi-vitamins, ginseng and tuber of dwarf lilyturf medicinal extract, Cordyceps militaris powder and minerals.The preparation method comprises the following steps: first obtaining the sodium alginate micro ball that cladding improves the immunity of the human body composition；Chitosan is added to the water and is stirred evenly, gel dispersion liquid is configured to；The sodium alginate micro ball surface for improving the immunity of the human body composition is coated by being sprayed at after gel dispersion liquid mist, is improved the matrimony vine capsule matrix of body immunity.Rationally, without any side effects, pharmacological property is mild, has the function of improving the immunity of the human body, and easy to produce, at low cost for matrimony vine capsule component proportion of the invention.
Description
Technical field
The invention belongs to health product technology field, it is related to a kind of matrimony vine capsule improved the immunity of the human body and its preparation side
Method.
Background technique
Sub-health state refers to that the body and mind of people is in a kind of healthy low-quality state between disease and health, though it is body nothing
Specific disease, but on body, psychologically there is various unconformable feelings and symptom, so that vigor be presented and fit to the external world
A kind of physiological status that stress reduces.According to one, World Health Organization it is global the survey showed that, there is 75% people in the whole world
In sub-health state.
Immunity degradation is a common feature of sub-health state, and it is people that immunity, which is the defense mechanism of human body itself,
Body identifies and eliminates virus and the bacterium of external intrusion, handles the cell of aging, damage, death, and identification and processing are in vivo
The ability of mutant cell and virus infected cell, the body of hypoimmunity are easy to infected or cancer stricken；A variety of causes makes to exempt from
Epidemic disease system cannot normally play protective effect, easily incur the infection such as bacterium, virus, fungi, liable to illness, if often suffered from
Disease can aggravate the consumption of body, cause to have a delicate constitution, malnutritive, apathetic, fatigue and weak, loss of appetite etc., seriously exempt from
The decline of epidemic disease power can also induce major disease.With the rapid development of modern industrial civilization, on the surface, people's lives water
Benefit improves on ordinary days, and still, the living environment of the mankind constantly deteriorates, environmental pollution, food pollution are got worse, in addition fast pace,
High pressure, irregular life style accumulate people's nutrient imbalance, toxin constantly, each dysfunction of organ of body, immunity
Decline, various chronic diseases are latent, seriously threaten health of people, and the presence of sub-health state more comes by public concern, therefore makes
The standby a product improved the immunity of the human body is highly desirable.
Summary of the invention
It is an object of the invention to provide a kind of matrimony vine capsules improved the immunity of the human body.Matrimony vine capsule of the invention is in addition to containing
Plurality of active ingredients, component proportion rationally, has the function of improving the immunity of the human body, and by way of capsule, easy to carry
With take.
To solve the above problems, the present invention adopts the following technical scheme:
A kind of matrimony vine capsule improved the immunity of the human body, including capsule shells and capsule base, the capsule base include that cladding mentions
The sodium alginate micro ball of high body immunity composition and the chitosan being coated on outside the sodium alginate micro ball；The raising
Body immunity composition includes 50-70 parts of fructus lycii fine powder, 10-20 parts of ganoderma lucidum polysaccharide, 5-10 parts of multi-vitamins, ginseng and wheat
Medicinal extract 20-30 parts of winter of door, 15-25 parts of Cordyceps militaris powder and 10-20 parts of minerals.Capsule shells of the invention are selected normal in the prior art
Conventional capsule shell.
As the further improvement of above-described embodiment, the fructus lycii fine powder is Ningxia lycium ruthenicum fine powder；The minerals are
One of zinc gluconate, copper gluconate or zinc sulfate.
As the further improvement of above-described embodiment, the multi-vitamins be vitamin A, vitamin B, vitamin C and
The mixture of vitamin D, wherein the ratio between mass fraction of vitamin A, vitamin B, vitamin C and vitamin D is 1:2:3:1.
As the further improvement of above-described embodiment, in the ginseng and tuber of dwarf lilyturf medicinal extract, the quality of ginseng and the tuber of dwarf lilyturf
The ratio between number is 1:2-3.
As the further improvement of above-described embodiment, the composition that improves the immunity of the human body includes improving the immunity of the human body
Composition includes 50 parts of fructus lycii fine powder, 15 parts of ganoderma lucidum polysaccharide, 10 parts of multi-vitamins, ginseng and 20 parts of tuber of dwarf lilyturf medicinal extract, pupa worm
20 parts and 10 parts of minerals of grass meal fine powder.
As the further improvement of above-described embodiment, the molecular weight of the chitosan is 5-10 ten thousand.
The present invention also provides a kind of preparation methods of matrimony vine capsule improved the immunity of the human body, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 3wt%, composition will be improved the immunity of the human body
It is proportionally added into sodium alginate aqueous solution, stirring is uniformly mixed it, and sodium alginate-is then improved the immunity of the human body group
It closes object mixed liquor to be transferred in constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 9%, and stirring is solid
Change 15-20 minute, filtering, be placed in 25-35 DEG C of vacuum drying, obtain coat improve the immunity of the human body composition sodium alginate it is micro-
Ball；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) bed spray is added in the sodium alginate micro ball that step (1) sodium alginate cladding improves the immunity of the human body composition
In pelletizer, adjusting fluidizing gas velocity is 2.5m/s, fluidized-bed layer temperature is 58 DEG C, atomization air pressure 0.3MPa, by step
(2) the sodium alginate micro ball table that cladding improves the immunity of the human body composition is uniformly sprayed at after chitosan gel rubber dispersion liquid atomization
Face, after fluidized drying is handled 25-35 minutes, the matrimony vine capsule matrix for being improved body immunity (forms graininess fructus lycii glue
Capsule matrix), the matrimony vine capsule matrix improved the immunity of the human body is added to the fructus lycii glue for being made and improving the immunity of the human body in capsule shells
Capsule.
As the further improvement of above-described embodiment, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is cut
Fructus lycii pulp is obtained to 2~3mm powder；B enzymatic hydrolysis: in the fructus lycii pulp obtained by step a, according to the quality of fructus lycii pulp and hydrolase
Than hydrolase is added for 100: 0.2~8, enzyme digestion reaction is carried out under constant temperature stirring condition, the time is 40-90 minutes, obtains fructus lycii
Digest pulp；The hydrolase is cellulase or the complex enzyme being made of pectase and cellulase；C freeze-drying: it will walk
It is to obtain fructus lycii dry crushing within 5% that fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by rapid b, which is freeze-dried under vacuum conditions to water content,
End；D is pulverized: the Chinese wolfberry fruit dry powder after step c freeze-drying process is pulverized the particle diameter to 90% less than 6
μm, obtain fructus lycii fine powder.
As the further improvement of above-described embodiment, the preparation method of the Cordyceps militaris powder specially freezes Cordyceps militaris powder
After dry, grind to powder and pulverize to 90% particle diameter less than 4 μm.
As the further improvement of above-described embodiment, the preparation method of the ginseng and tuber of dwarf lilyturf medicinal extract is ginseng and Mai Men
Green bean noodle end is added in ethyl alcohol, impregnates, and decocts, is concentrated to get medicinal extract, dry.
As the further improvement of above-described embodiment, the time of the immersion is 0.5h~2h；The temperature of the decoction
Degree is 80 DEG C~100 DEG C；The relative density of the medicinal extract is 1.1~1.4 at 60 DEG C.
Beneficial effect
The matrimony vine capsule improved the immunity of the human body of the invention uses sodium alginate as shell, combines to improving the immunity of the human body
Object is tentatively coated, and is utilized aldehyde groups later, is crosslinked and react with chitosan, is coated raising human body in sodium alginate and is exempted from
Epidemic disease power composition surface introduces temperature sensitive polymer, realizes and coats to the double-layer sustained release for improving the immunity of the human body composition, reaches slow
The effect for improving the immunity of the human body composition is released and protected, nutrition loss and waste are reduced.
The matrimony vine capsule improved the immunity of the human body of the invention has good antibacterial activity using chitosan shell, not
The pollution of matrimony vine capsule is avoided in the case where the additives such as preservative are added.
The matrimony vine capsule improved the immunity of the human body of the invention is coated first using sodium alginate improves the immunity of the human body group
Object is closed, improves the immunity of the human body and contains traditional Chinese medicine ingredients in composition, Chinese medicine taste will affect mouthfeel, poly- by sodium alginate and shell
What the double shielding of sugar can also improve matrimony vine capsule takes mouthfeel.
Ginseng in inventive formulation is the drying root and rhizome of Araliaceae ginseng panax ginsengC, A, Mey.
Nature and flavor are sweet, slight bitter, returns spleen, lung, the heart channel of Hang-Shaoyin, ginseng have reinforce vital energy, veins takes off admittedly, reinforce the spleen to benefit the lung, promoting production of body fluid and inducing sedation of the mind effect is
The traditional traditional tonic medicine in China has more than 4,000 years applicating histories, and history tree is on the books, and " Dragon Lord book on Chinese herbal medicine warp " is by ginseng
It is classified as top grade；Record in " food book on Chinese herbal medicine ": " ginseng is sweet in flavor slightly cold, nontoxic.Main bushing is dirty, soothe the nerves, determines soul, and stop palpitate with fear is removed
Perverse trend, the happy intelligence development of improving eyesight, long term usage are made light of one's life by commiting suicide macrobiosis." ginseng energy building up healthful vital energy, training tonifying spleen and stomach, the premunition for enhancing human body, therefore
Has the function of strengthen immunity.
The tuber of dwarf lilyturf in inventive formulation is liliaceous plant Radix Ophiopogonis Ophinopogon japonicus(Thunb.) Ker-
Gawl. dried root.Nature and flavor are sweet, slight bitter, slightly cold.Return heart, lung, stomach meridian.With nourishing Yin and promoting production of body fluid, the effect of moistening lung and clearing away the heart-fire, make
For the product of reinforcing both QI and YIN, it is widely used in clinic." Dragon Lord book on Chinese herbal medicine warp " is classified as top grade；Song Dynasty " figure is through book on Chinese herbal medicine " carries: the tuber of dwarf lilyturf
It decocts, heat wineization clothes, there is the effect of " bowl spares invigorating heart, beneficial color, tranquilizing the mind QI invigorating ".The tuber of dwarf lilyturf in clinical application, is not only attached most importance to
The tonifying yin drug wanted, and play the role of tonifying Qi invigorating heart.It not only helps the effect of helping ginseng qi-tonifying, and can play feeding with ginseng compatibility
The effect of yin." ginseng wheat dissipates " is the classical recipe for treating syndrome of deficiency of both qi and yin, and more clinical reports show different deficiency of both qi and yin sides
For medicine to the adjuvant treatment of tumour patient, the Analysis on Mechanism enhanced from immunity shows good auxiliary therapeutic action." high and level tone sun
Secret, the life activities being normally maintained " tuber of dwarf lilyturf improves the immunity of the human body aspect and plays important work in enriching yin, tonifying Qi, adjustment human body yin-yang balancing
With.
The present invention is by a variety of vitamins with strengthen immunity, minerals and Chinese medicine group containing inhomogeneity chemical component
It is combined, gives full play to their synergistic effect.Such as: minerals zinc can not only participate in immune function, promote appetite, promote
Growth and regeneration, moreover it is possible to promote the metabolism and physiological action of vitamin A.For another example: if vitamin E is to vitamin A and Wei Sheng
Plain C has protective effect, can promote storage of the vitamin A in liver.Vitamin C can be by improving other antioxidants in human body
Level, enhance the immune function of body.The present invention chooses specific effective for the trophic structure and life characteristic of specific crowd
Ingredient is suitble to children, old man and white collar clan to use.For example, vitamin C helps to consolidate cell tissue, strong bone and tooth
Tooth enhances immune system, promotes the absorption of irony；Zinc not only can strengthen immunity, can also maintain dysregulated appetite, promote children raw
Long development.Vitamin C, the minerals zinc added in the present invention, not only can be improved the immunity of user, can more be directed to children
Physilogical characteristics, promote its growth and development.For another example, the present invention is directed to the characteristics of the elderly, and immunity not only can be improved in selection, but also right
Beneficial minerals are remembered in cardiovascular and cerebrovascular health and improvement.The shortage of copper can cause memory of the elder to decline；Magnesium is living to heart
It is dynamic that there is important adjustment effect, be conducive to the diastole and rest of heart；And the content of Blood Cholesterol can be reduced, anti-stop
Arteries and veins hardening；Energy coronary artery dilator, increases heart blood supply amount；It cardioprotection can also escape injury when blood supply is obstructed suddenly, from
And prevents heart disease and reduce the heart attack death rate.For another example, the present invention is for white collar clan's activity indoors, use for a long time
The life characteristics such as machine time is longer, often stays up late, suitably increase the content of vitamin C, VITAMIN EVitamin.For a long time
It works before computer and will appear the computer syndromes such as lassitude, eye-blurred, this is the knot that body vitamin A largely consumes
Fruit.
Matrimony vine capsule of the invention reuses ginseng spleen strengthening QI invigorating qi-restoratives, and inducing diuresis for removing edema is monarch, compatibility semen astragali complanati, the tuber of dwarf lilyturf
It tonifies the liver and kidney, astringent sperm contracting urine；And with Cordyceps militaris powder, fructus lycii, minerals kidney tonifying arresting seminal emission, invigorating the spleen dehumidifying；Minerals: cure mainly kidney tonifying,
Moisturizing viscera.Kidney deficiency and liver, empty wind dizziness are controlled, wandering arthritis is paralysed, dry feces, virtual winning after being ill, poliosis, and married woman's cream is few.Gu Nong
Medical book is recorded: Cordyceps militaris powder " enriching yin and nourishing kidney, body-building warm stomach, improving eyesight promoting blood circulation ", " clearing liver ease constipation ", " sliding wet strengthening the essence, tonifying lung delay muscle "
And other effects；Can be used as medicine into meals, to Light-headedness, anaemia white hair, soreness and weakness of waist and knees, yctalopia tinnitus disease, curative effect it is further preferred that.The nature and flavor of fructus lycii
Gan Ping, Chinese medicine think that it being capable of nourishing liver and kidney, benefiting shrewd head and blood-nourishing, the immunity for enhancing people.Ganoderma lucidum polysaccharide, compound dimension
Raw element can play the role of delaying body aging with anti-oxidation protection body cell from the murder by poisoning of free radical.
This matrimony vine capsule of the invention, material combination composition formula is reasonable, has through pharmacological testing and clinical proof and improves
The effect of body immunity.
Specific embodiment
The invention will be further elucidated with reference to specific embodiments.It should be understood that these embodiments are merely to illustrate this hair
It is bright rather than limit the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, art technology
Personnel can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Fixed range.
Embodiment 1
A kind of matrimony vine capsule improved the immunity of the human body, including capsule shells and capsule base, capsule base include that cladding improves people
The sodium alginate micro ball of body immunity composition and the chitosan being coated on outside sodium alginate micro ball；Improve the immunity of the human body group
Closing object includes 50 parts of fructus lycii fine powder, 10 parts of ganoderma lucidum polysaccharide, 10 parts of multi-vitamins, ginseng and 30 parts of tuber of dwarf lilyturf medicinal extract, Cordyceps militaris
15 parts of powder and 20 parts of minerals, in ginseng and tuber of dwarf lilyturf medicinal extract, the ratio between mass fraction of ginseng and the tuber of dwarf lilyturf is 1:2.Minerals
For zinc gluconate, copper gluconate or zinc sulfate；Multi-vitamins are vitamin A, vitamin B, vitamin C and vitamin D
Mixture, wherein the ratio between mass fraction of vitamin A, vitamin B, vitamin C and vitamin D be 1:2:3:1.
Wherein, fructus lycii fine powder is Ningxia lycium ruthenicum fine powder, and the molecular weight of chitosan is 100,000.
The preparation method of the above-mentioned matrimony vine capsule improved the immunity of the human body, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 3wt%, composition will be improved the immunity of the human body
It is proportionally added into sodium alginate aqueous solution, stirring is uniformly mixed it, and sodium alginate-is then improved the immunity of the human body group
It closes object mixed liquor to be transferred in constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 9%, and stirring is solid
Change 15 minutes, filtering is placed in 35 DEG C of vacuum drying, obtains the sodium alginate micro ball that cladding improves the immunity of the human body composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) bed spray is added in the sodium alginate micro ball that step (1) sodium alginate cladding improves the immunity of the human body composition
In pelletizer, adjusting fluidizing gas velocity is 2.5m/s, fluidized-bed layer temperature is 58 DEG C, atomization air pressure 0.3MPa, by step
(2) the sodium alginate micro ball table that cladding improves the immunity of the human body composition is uniformly sprayed at after chitosan gel rubber dispersion liquid atomization
Face is improved the matrimony vine capsule matrix of body immunity, the Chinese holly that will be improved the immunity of the human body after fluidized drying is handled 25 minutes
The matrimony vine capsule for being made and improving the immunity of the human body in capsule shells is added in Qi capsule base.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 3mm powder and obtains fructus lycii pulp；B enzyme
Solution: being 100: 0.2 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase, in perseverance in the fructus lycii pulp obtained by step a
Enzyme digestion reaction is carried out under warm stirring condition, the time is 40 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by pectin
The complex enzyme of enzyme and cellulase composition；C freeze-drying: by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b in vacuum condition
Lower freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5%；D is pulverized: will be after step c freeze-drying process
Chinese wolfberry fruit dry powder is pulverized to 90% particle diameter less than 6 μm, obtains fructus lycii fine powder.
The preparation method of Cordyceps militaris powder, specially will Cordyceps militaris powder freeze-drying after, grind to powder pulverize to
90% particle diameter is less than 4 μm.
The preparation method of ginseng and tuber of dwarf lilyturf medicinal extract is that ginseng and tuber of dwarf lilyturf powder are added in ethyl alcohol, impregnates, decocts, concentration
Medicinal extract is obtained, it is dry；The time wherein impregnated is 2h；Decoction temperature be 80 DEG C；Medicinal extract at 60 DEG C it is relatively close
Degree is 1.1.
Embodiment 2
A kind of matrimony vine capsule improved the immunity of the human body, including capsule shells and capsule base, capsule base include that cladding improves people
The sodium alginate micro ball of body immunity composition and the chitosan being coated on outside sodium alginate micro ball；Improve the immunity of the human body group
Closing object includes 70 parts of fructus lycii fine powder, 20 parts of ganoderma lucidum polysaccharide, 5 parts of multi-vitamins, ginseng and 20 parts of tuber of dwarf lilyturf medicinal extract, Cordyceps militaris powder
25 parts and 10 parts of minerals, in ginseng and tuber of dwarf lilyturf medicinal extract, the ratio between mass fraction of ginseng and the tuber of dwarf lilyturf is 1:3.Minerals are
Zinc gluconate；Multi-vitamins be vitamin A, vitamin B, vitamin C and vitamin D mixture, wherein vitamin A,
The ratio between mass fraction of vitamin B, vitamin C and vitamin D is 1:2:3:1.
Wherein, fructus lycii fine powder is Ningxia lycium ruthenicum fine powder, and the molecular weight of chitosan is 50,000.
The preparation method of the above-mentioned matrimony vine capsule improved the immunity of the human body, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 3wt%, composition will be improved the immunity of the human body
It is proportionally added into sodium alginate aqueous solution, stirring is uniformly mixed it, and sodium alginate-is then improved the immunity of the human body group
It closes object mixed liquor to be transferred in constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 9%, and stirring is solid
Change 20 minutes, filtering is placed in 25 DEG C of vacuum drying, obtains the sodium alginate micro ball that cladding improves the immunity of the human body composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) bed spray is added in the sodium alginate micro ball that step (1) sodium alginate cladding improves the immunity of the human body composition
In pelletizer, adjusting fluidizing gas velocity is 2.5m/s, fluidized-bed layer temperature is 58 DEG C, atomization air pressure 0.3MPa, by step
(2) the sodium alginate micro ball table that cladding improves the immunity of the human body composition is uniformly sprayed at after chitosan gel rubber dispersion liquid atomization
Face is improved the matrimony vine capsule matrix of body immunity, the Chinese holly that will be improved the immunity of the human body after fluidized drying is handled 35 minutes
The matrimony vine capsule for being made and improving the immunity of the human body in capsule shells is added in Qi capsule base.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2mm powder and obtains fructus lycii pulp；B enzyme
Solution: being 100: 8 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase, in constant temperature in the fructus lycii pulp obtained by step a
Enzyme digestion reaction is carried out under stirring condition, the time is 90 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by pectase
With the complex enzyme of cellulase composition；C freeze-drying: under vacuum conditions by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b
Freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5%；D is pulverized: by the Chinese holly after step c freeze-drying process
Qi dry crushing end is pulverized to 90% particle diameter less than 6 μm, obtains fructus lycii fine powder.
The preparation method of Cordyceps militaris powder, specially will Cordyceps militaris powder freeze-drying after, grind to powder pulverize to
90% particle diameter is less than 4 μm.The preparation method of ginseng and tuber of dwarf lilyturf medicinal extract is that second is added in ginseng and tuber of dwarf lilyturf powder
It in alcohol, impregnates, decocts, be concentrated to get medicinal extract, it is dry；The time of immersion is 0.5h；100 DEG C of temperature of decoction；60℃
Under medicinal extract relative density be 1.4.
Embodiment 3
A kind of matrimony vine capsule improved the immunity of the human body, including capsule shells and capsule base, capsule base include that cladding improves people
The sodium alginate micro ball of body immunity composition and the chitosan being coated on outside sodium alginate micro ball；Improve the immunity of the human body group
Closing object includes 30 parts of fructus lycii fine powder, 20 parts of ganoderma lucidum polysaccharide, 8 parts of multi-vitamins, ginseng and 30 parts of tuber of dwarf lilyturf medicinal extract, Cordyceps militaris powder
25 parts of fine powder and 20 parts of minerals, in ginseng and tuber of dwarf lilyturf medicinal extract, the ratio between mass fraction of ginseng and the tuber of dwarf lilyturf is 1:2.5.Mine
Substance is copper gluconate；Multi-vitamins are the mixture of vitamin A, vitamin B, vitamin C and vitamin D, wherein tieing up
The ratio between raw element A, vitamin B, vitamin C and mass fraction of vitamin D are 1:2:3:1.
Wherein, fructus lycii fine powder is Ningxia lycium ruthenicum fine powder, and the molecular weight of chitosan is 70,000.
The preparation method of the above-mentioned matrimony vine capsule improved the immunity of the human body, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 3wt%, composition will be improved the immunity of the human body
It is proportionally added into sodium alginate aqueous solution, stirring is uniformly mixed it, and sodium alginate-is then improved the immunity of the human body group
It closes object mixed liquor to be transferred in constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 9%, and stirring is solid
Change 18 minutes, filtering is placed in 30 DEG C of vacuum drying, obtains the sodium alginate micro ball that cladding improves the immunity of the human body composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) bed spray is added in the sodium alginate micro ball that step (1) sodium alginate cladding improves the immunity of the human body composition
In pelletizer, adjusting fluidizing gas velocity is 2.5m/s, fluidized-bed layer temperature is 58 DEG C, atomization air pressure 0.3MPa, by step
(2) the sodium alginate micro ball table that cladding improves the immunity of the human body composition is uniformly sprayed at after chitosan gel rubber dispersion liquid atomization
Face is improved the matrimony vine capsule matrix of body immunity, the Chinese holly that will be improved the immunity of the human body after fluidized drying is handled 30 minutes
The matrimony vine capsule for being made and improving the immunity of the human body in capsule shells is added in Qi capsule base.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2.3mm powder and obtains fructus lycii pulp；b
Enzymatic hydrolysis: being 100: 6 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase, in perseverance in the fructus lycii pulp obtained by step a
Enzyme digestion reaction is carried out under warm stirring condition, the time is 70 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by pectin
The complex enzyme of enzyme and cellulase composition；C freeze-drying: by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b in vacuum condition
Lower freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5%；D is pulverized: will be after step c freeze-drying process
Chinese wolfberry fruit dry powder is pulverized to 90% particle diameter less than 6 μm, obtains fructus lycii fine powder.
The preparation method of Cordyceps militaris powder, specially will Cordyceps militaris powder freeze-drying after, grind to powder pulverize to
90% particle diameter is less than 4 μm.The preparation method of ginseng and tuber of dwarf lilyturf medicinal extract is that second is added in ginseng and tuber of dwarf lilyturf powder
It in alcohol, impregnates, decocts, be concentrated to get medicinal extract, it is dry；The time of immersion is 1h；Decoction temperature be 90 DEG C；At 60 DEG C
Medicinal extract relative density be 1.3.
Embodiment 4
A kind of matrimony vine capsule improved the immunity of the human body, including capsule shells and capsule base, capsule base include that cladding improves people
The sodium alginate micro ball of body immunity composition and the chitosan being coated on outside sodium alginate micro ball；Improve the immunity of the human body group
Closing object includes 50 parts of fructus lycii fine powder, 15 parts of ganoderma lucidum polysaccharide, 10 parts of multi-vitamins, ginseng and 20 parts of tuber of dwarf lilyturf medicinal extract, Cordyceps militaris
20 parts of powder and fine powder and 10 parts of minerals, in ginseng and tuber of dwarf lilyturf medicinal extract, the ratio between mass fraction of ginseng and the tuber of dwarf lilyturf is 1:3.Mine
Substance is zinc sulfate；Multi-vitamins are the mixture of vitamin A, vitamin B, vitamin C and vitamin D, wherein vitamin
A, the ratio between mass fraction of vitamin B, vitamin C and vitamin D is 1:2:3:1.
Wherein, fructus lycii fine powder is Ningxia lycium ruthenicum fine powder, and the molecular weight of chitosan is 80,000
The preparation method of the above-mentioned matrimony vine capsule improved the immunity of the human body, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 3wt%, composition will be improved the immunity of the human body
It is proportionally added into sodium alginate aqueous solution, stirring is uniformly mixed it, and sodium alginate-is then improved the immunity of the human body group
It closes object mixed liquor to be transferred in constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 9%, and stirring is solid
Change 16 minutes, filtering is placed in 28 DEG C of vacuum drying, obtains the sodium alginate micro ball that cladding improves the immunity of the human body composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) bed spray is added in the sodium alginate micro ball that step (1) sodium alginate cladding improves the immunity of the human body composition
In pelletizer, adjusting fluidizing gas velocity is 2.5m/s, fluidized-bed layer temperature is 58 DEG C, atomization air pressure 0.3MPa, by step
(2) the sodium alginate micro ball table that cladding improves the immunity of the human body composition is uniformly sprayed at after chitosan gel rubber dispersion liquid atomization
Face is improved the matrimony vine capsule matrix of body immunity, the Chinese holly that will be improved the immunity of the human body after fluidized drying is handled 26 minutes
The matrimony vine capsule for being made and improving the immunity of the human body in capsule shells is added in Qi capsule base.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2.53mm powder and obtains fructus lycii pulp；
B enzymatic hydrolysis: being 100: 5 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase in the fructus lycii pulp obtained by step a,
Enzyme digestion reaction is carried out under constant temperature stirring condition, the time is 60 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by fruit
The complex enzyme of glue enzyme and cellulase composition；C freeze-drying: by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b in vacuum item
Freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5% under part；D is pulverized: will be after step c freeze-drying process
Chinese wolfberry fruit dry powder pulverize to 90% particle diameter less than 6 μm, obtain fructus lycii fine powder.
The preparation method of Cordyceps militaris powder, specially will Cordyceps militaris powder freeze-drying after, grind to powder pulverize to
90% particle diameter is less than 4 μm.The preparation method of ginseng and tuber of dwarf lilyturf medicinal extract is that second is added in ginseng and tuber of dwarf lilyturf powder
It in alcohol, impregnates, decocts, be concentrated to get medicinal extract, it is dry；The time of immersion is 1.5h；Decoction temperature be 85 DEG C；60℃
Under medicinal extract relative density be 1.3.
Embodiment 5
A kind of matrimony vine capsule improved the immunity of the human body, including capsule shells and capsule base, capsule base include that cladding improves people
The sodium alginate micro ball of body immunity composition and the chitosan being coated on outside sodium alginate micro ball；Improve the immunity of the human body group
Closing object includes 45 parts of fructus lycii fine powder, 15 parts of ganoderma lucidum polysaccharide, 9 parts of multi-vitamins, ginseng and 25 parts of tuber of dwarf lilyturf medicinal extract, Cordyceps militaris powder
16 parts of fine powder and 16 parts of minerals, in ginseng and tuber of dwarf lilyturf medicinal extract, the ratio between mass fraction of ginseng and the tuber of dwarf lilyturf is 1:2.Wherein,
Fructus lycii fine powder is Ningxia lycium ruthenicum fine powder, and the molecular weight of chitosan is 80,000.Minerals are zinc gluconate；Multi-vitamins are
Vitamin A, vitamin B, vitamin C and vitamin D mixture, wherein vitamin A, vitamin B, vitamin C and vitamin D
The ratio between mass fraction be 1:2:3:1.
The preparation method of the above-mentioned matrimony vine capsule improved the immunity of the human body, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 3wt%, composition will be improved the immunity of the human body
It is proportionally added into sodium alginate aqueous solution, stirring is uniformly mixed it, and sodium alginate-is then improved the immunity of the human body group
It closes object mixed liquor to be transferred in constant pressure funnel, uniform speed slow is added dropwise in the calcium chloride water that concentration is 9%, and stirring is solid
Change 16 minutes, filtering is placed in 28 DEG C of vacuum drying, obtains the sodium alginate micro ball that cladding improves the immunity of the human body composition；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) bed spray is added in the sodium alginate micro ball that step (1) sodium alginate cladding improves the immunity of the human body composition
In pelletizer, adjusting fluidizing gas velocity is 2.5m/s, fluidized-bed layer temperature is 58 DEG C, atomization air pressure 0.3MPa, by step
(2) the sodium alginate micro ball table that cladding improves the immunity of the human body composition is uniformly sprayed at after chitosan gel rubber dispersion liquid atomization
Face is improved the matrimony vine capsule matrix of body immunity, the Chinese holly that will be improved the immunity of the human body after fluidized drying is handled 26 minutes
The matrimony vine capsule for being made and improving the immunity of the human body in capsule shells is added in Qi capsule base.
Wherein, fructus lycii fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2.53mm powder and obtains fructus lycii pulp；
B enzymatic hydrolysis: being 100: 5 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase in the fructus lycii pulp obtained by step a,
Enzyme digestion reaction is carried out under constant temperature stirring condition, the time is 60 minutes, obtains fructus lycii enzymatic hydrolysis pulp；Hydrolase is for cellulase or by fruit
The complex enzyme of glue enzyme and cellulase composition；C freeze-drying: by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b in vacuum item
Freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5% under part；D is pulverized: will be after step c freeze-drying process
Chinese wolfberry fruit dry powder pulverize to 90% particle diameter less than 6 μm, obtain fructus lycii fine powder.
The preparation method of Cordyceps militaris powder, specially will Cordyceps militaris powder freeze-drying after, grind to powder pulverize to
90% particle diameter is less than 4 μm.The preparation method of ginseng and tuber of dwarf lilyturf medicinal extract is that second is added in ginseng and tuber of dwarf lilyturf powder
It in alcohol, impregnates, decocts, be concentrated to get medicinal extract, it is dry；The time of immersion is 1.5h；Decoction temperature be 85 DEG C；60℃
Under medicinal extract relative density be 1.3.
Two, performance detection
The health care product of raising immunity of the invention passes through clinical verification, obtains different degrees of good curative effect.Now enumerate it
In three cases:
1. Mr. Wang, male, 55 years old.Often giddy headache, fatigue and weak, loss of appetite, spirit are poor, will feel when changing solar term every time
It emits, usually and minor illness is continuous.After taking this product one month, above-mentioned symptom is obviously improved；After persistently taking, mentality
Good, without obvious tired sense, appetite is good, and complexion, changing solar term every time will not easily catch a cold, and is usually even more no longer
Sick easily, work is worked also energetic.
2. Liu, female, 48 years old.Often in poor health, deficient in energy, complexion is poor, feels dizzy, and resistance is poor, often exists
It is sick when Changes in weather.After taking this product one month, above-mentioned symptom is improved well；After persistently taking, have rosy cheeks,
It is in high spirits, body be good for it is bright, will not be sick easily in Changes in weather, resistance is remarkably reinforced.
3. Qian, male, 59 years old.Body has a delicate constitution, malnutritive, apathetic, fatigue and weak, and loss of appetite is immunized
Power decline, is easy illness.After taking this product one month, above-mentioned symptom has and significantly improves；After persistently taking, body constitution increases
By force, appetite enhances, hale and hearty, without obvious tired sense, immunity enhancing, it is not easy to illness.
Claims (9)
1. a kind of matrimony vine capsule improved the immunity of the human body, characterized in that including capsule shells and capsule base, the capsule base
It is poly- including coating the sodium alginate micro ball for improving the immunity of the human body composition and the shell being coated on outside the sodium alginate micro ball
Sugar；The composition that improves the immunity of the human body includes 50-70 parts of fructus lycii fine powder, 10-20 parts of ganoderma lucidum polysaccharide, multi-vitamins 5-10
Part, ginseng and 20-30 parts of tuber of dwarf lilyturf medicinal extract, 15-25 parts of Cordyceps militaris powder and 10-20 parts of minerals.
2. a kind of matrimony vine capsule improved the immunity of the human body according to claim 1, which is characterized in that the ginseng and wheat
In door winter medicinal extract, the ratio between mass fraction of ginseng and the tuber of dwarf lilyturf is 1:2-3.
3. a kind of matrimony vine capsule improved the immunity of the human body according to claim 1, which is characterized in that the minerals are
One of zinc gluconate, copper gluconate or zinc sulfate.
4. a kind of matrimony vine capsule improved the immunity of the human body according to claim 1, which is characterized in that the compound dimension life
Element is the mixture of vitamin A, vitamin B, vitamin C and vitamin D, wherein vitamin A, vitamin B, vitamin C and dimension
The ratio between the mass fraction of raw element D is 1:2:3:1.
5. a kind of preparation method of matrimony vine capsule improved the immunity of the human body according to claim 1 to 4, feature
It is, comprising the following steps:
(1) sodium alginate is dissolved in the sodium alginate aqueous solution that distilled water is configured to 3wt%, composition will be improved the immunity of the human body
It is proportionally added into sodium alginate aqueous solution, stirring is uniformly mixed it, and sodium alginate-is then improved the immunity of the human body group
The mixed liquor for closing object is transferred in constant pressure funnel, and uniform speed slow is added dropwise in the calcium chloride water that concentration is 9%, stirring
Solidification 15-20 minutes, filtering, is placed in 25-35 DEG C of vacuum drying, obtains the sodium alginate that cladding improves the immunity of the human body composition
Microballoon；
(2) chitosan is added to the water and is stirred evenly, the gel dispersion liquid for being configured to 10wt% is spare；
(3) bed spray is added in the sodium alginate micro ball that step (1) sodium alginate cladding improves the immunity of the human body composition
In pelletizer, adjusting fluidizing gas velocity is 2.5m/s, fluidized-bed layer temperature is 58 DEG C, atomization air pressure 0.3MPa, by step
(2) the sodium alginate micro ball table that cladding improves the immunity of the human body composition is uniformly sprayed at after chitosan gel rubber dispersion liquid atomization
Face is improved the matrimony vine capsule matrix of body immunity, will improve the immunity of the human body after fluidized drying is handled 25-35 minutes
Matrimony vine capsule matrix be added in capsule shells the matrimony vine capsule that improves the immunity of the human body be made.
6. a kind of preparation method of matrimony vine capsule improved the immunity of the human body according to claim 5, which is characterized in that Chinese holly
Qi fine powder the preparation method comprises the following steps: a slurrying: the fructus lycii of stoning is switched to 2~3mm powder and obtains fructus lycii pulp；B enzymatic hydrolysis: in step a institute
It obtains in fructus lycii pulp, is 100: 0.2~8 addition hydrolases according to the mass ratio of fructus lycii pulp and hydrolase, in constant temperature stirring bar
Enzyme digestion reaction is carried out under part, the time is 40-90 minutes, obtains fructus lycii enzymatic hydrolysis pulp；The hydrolase is for cellulase or by pectin
The complex enzyme of enzyme and cellulase composition；C freeze-drying: by the fructus lycii enzymatic hydrolysis pulp after enzymatic hydrolysis obtained by step b in vacuum condition
Lower freeze-drying to water content is to obtain Chinese wolfberry fruit dry powder within 5%；D is pulverized: will be after step c freeze-drying process
Chinese wolfberry fruit dry powder is pulverized to 90% particle diameter less than 6 μm, obtains fructus lycii fine powder.
7. a kind of preparation method of matrimony vine capsule improved the immunity of the human body according to claim 5, which is characterized in that institute
The preparation method of Cordyceps militaris powder is stated, specially by after the freeze-drying of Cordyceps militaris powder, grinds to powder and pulverizes to 90%
Grain diameter is less than 4 μm.
8. a kind of preparation method of matrimony vine capsule improved the immunity of the human body according to claim 5, which is characterized in that institute
The preparation method for stating ginseng and tuber of dwarf lilyturf medicinal extract is that ginseng and tuber of dwarf lilyturf powder are added in ethyl alcohol, impregnates, decocts, be concentrated to get leaching
Cream, it is dry.
9. a kind of preparation method of matrimony vine capsule improved the immunity of the human body according to claim 8, which is characterized in that institute
The time for stating immersion is 0.5h~2h；The temperature of the decoction is 80 DEG C~100 DEG C；The relative density of the medicinal extract at 60 DEG C
It is 1.1~1.4.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116440204A (en) * | 2023-04-26 | 2023-07-18 | 江西维莱营健高科有限公司 | Capsule with immunity enhancing function and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116440204A (en) * | 2023-04-26 | 2023-07-18 | 江西维莱营健高科有限公司 | Capsule with immunity enhancing function and preparation method thereof |
| CN116440204B (en) * | 2023-04-26 | 2024-01-30 | 江西维莱营健高科有限公司 | Capsule with immunity enhancing function and preparation method thereof |
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Application publication date: 20190419 |