CN107875136B - Amoxicillin medicinal preparation and preparation method thereof - Google Patents
Amoxicillin medicinal preparation and preparation method thereof Download PDFInfo
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- CN107875136B CN107875136B CN201711441039.7A CN201711441039A CN107875136B CN 107875136 B CN107875136 B CN 107875136B CN 201711441039 A CN201711441039 A CN 201711441039A CN 107875136 B CN107875136 B CN 107875136B
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- amoxicillin
- preparation
- capsule
- magnesium stearate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
Abstract
The invention discloses an amoxicillin medicinal preparation and a preparation method thereof. The amoxicillin preparation comprises the following components in parts by mass: 90.0-99.9 parts of amoxicillin and 0.1-10.0 parts of magnesium stearate; the preparation method is a dry pressing method. The invention can ensure good dissolution and stability of the amoxicillin preparation by controlling the amoxicillin particle size distribution, the magnesium stearate particle size distribution and the pressure of a dry press.
Description
Technical Field
The invention relates to the field of pharmaceutical preparations, in particular to an amoxicillin capsule and a preparation method thereof.
Background
Amoxicillin is a broad-spectrum antibiotic, exerts a bactericidal effect by inhibiting the synthesis of bacterial cell walls, can make bacteria quickly become spheroids to be dissolved and broken, has strong and quick killing effect on gram-negative bacteria and gram-positive bacteria, and also has killing effect on leptospira. As the best choice of the WHO, the oral beta-lactam antibiotic, amoxicillin, has good effects on the infection of the respiratory system, the urinary system, the digestive system and the like. The amoxicillin oral dosage form comprises tablets, capsules, granules, dispersible tablets and the like, wherein the amoxicillin capsules are commonly used in clinic and are listed as national medical Baojia type varieties.
However, amoxicillin has poor solubility, is slightly soluble in water and is insoluble in ethanol, so that the prepared amoxicillin capsule has poor dissolution rate and becomes a key factor for limiting the absorption in vivo; in addition, amoxicillin is sensitive to humidity and heat, has poor stability under high temperature and high humidity, obviously increases polymers and impurities, and is easy to cause anaphylactic reaction.
CN 103417512B discloses an amoxicillin capsule and a preparation method thereof, the amoxicillin capsule is prepared by uniformly mixing drug-containing granules and a lubricant and the like and then loading the mixture into a capsule shell, wherein the drug-containing granules comprise amoxicillin and tartaric acid, and the amoxicillin capsule is prepared by adding absolute ethyl alcohol into the mixture and carrying out wet granulation. Although the dissolution rate and the stability of the medicine can be improved, the prescription composition and the preparation process are complex, and the absolute ethyl alcohol granulation has great potential safety hazard. CN101390846B discloses an amoxicillin capsule and a production method thereof, the amoxicillin capsule is prepared by adopting a micronization technology, and the prescription of the amoxicillin capsule consists of a plurality of components of amoxicillin, a filling agent, a disintegrating agent, a binding agent and/or a glidant. Although the dissolution rate is improved after the amoxicillin is micronized, the preparation process is complex, and the stability of the amoxicillin is not improved; meanwhile, due to the increase of the surface area, the contact with external moisture is increased, and the polymer is easier to generate. CN 104887645B discloses an amoxicillin capsule and a preparation method thereof, wherein the prescription of the amoxicillin capsule is composed of amoxicillin, sodium carboxymethyl starch, talcum powder and magnesium stearate, and the amoxicillin capsule is obtained by dry granulation, and can take account of both the volume size of the capsule and the drug dissolution (which can reach more than 90%). But also has the defect of complex prescription composition. CN 104856972A discloses an amoxicillin capsule and a preparation method thereof, wherein the amoxicillin capsule comprises the components of amoxicillin, sodium dodecyl sulfate, talcum powder and
magnesium stearate, which ensures higher dissolution of the amoxicillin capsule by adjusting the particle size of the raw material amoxicillin particles and adjusting the proportion of the auxiliary materials. However, the auxiliary materials used in the prescription are more than three, and the added surfactant, namely sodium dodecyl sulfate, has certain toxic and side effects on human bodies.
Therefore, the prescription, process and the like of the amoxicillin capsule need to be studied deeply.
Disclosure of Invention
The invention aims to realize the rapid dissolution of the amoxicillin capsule and improve the stability of the amoxicillin capsule under the condition of using less auxiliary materials.
The inventors have unexpectedly found in a number of experimental studies that the selection of only magnesium stearate as an adjuvant, while controlling the amoxicillin particle size distribution, magnesium stearate particle size distribution and pressure during dry pressing, can achieve this objective, and that the resulting formulation has good stability.
Specifically, the object of the present invention is achieved by:
an amoxicillin capsule comprises amoxicillin and magnesium stearate, and the mass fraction is as follows: 90.0-99.9 parts of amoxicillin and 0.1-10.0 parts of magnesium stearate.
The particle size distribution of the amoxicillin is D102.5-7.0 μm, D507.0-20.0 μm and D9012.0-45.0 μm (namely, the weight proportion of the amoxicillin with the diameter of 2.5-7.0 μm is 10%, the weight proportion of the amoxicillin with the diameter of 7.0-20.0 μm is 50%, and the weight proportion of the amoxicillin with the diameter of 15.0-40.0 μm is 90%); the particle size distribution of magnesium stearate is D104.0-14.0 μm, D5015.0-28.0 μm, and D9030.0-50.0 μm.
Preferably, the mass fraction of the amoxicillin is 92.0 to 96.0, and the mass fraction of the magnesium stearate is 4.0 to 8.0 parts.
Preferably, the particle size distribution of the amoxicillin is D103.0-6.0 μm, D508.0-18.0 μm and D9015.0-40.0 μm; the particle size distribution of magnesium stearate is D106.0-12.0 μm, D5018.0-24.0 μm, and D9037.0-47.0 μm.
The invention also provides a preparation method of the amoxicillin capsule, which comprises the following steps
(1) And (3) dry granulation: drying an amoxicillin raw material by airflow, adding the dried amoxicillin raw material into a dry press for granulation, granulating by a granulator, and sieving by a rotary vibration sieve to obtain amoxicillin heavy powder granules;
(2) mixing: pulverizing magnesium stearate, sieving with a rotary vibration sieve, adding into a powder mixing machine together with amoxicillin heavy powder particles, and mixing;
(3) filling: and filling the mixed medicinal powder into capsules by using a capsule filling machine.
Wherein, the pressure of the dry press is 60-150 bar.
Preferably, the dry press pressure is 90-130 bar.
Preferably, the amoxicillin capsule contains 0.125-0.5 g of amoxicillin per unit of preparation.
Compared with the prior art, the amoxicillin capsule provided by the invention only uses one auxiliary material, the prescription composition is simple, and the production cost is obviously reduced; and the prepared amoxicillin capsule has good dissolution. After accelerated investigation, the related substances and polymers are not obviously increased, and the stability is good.
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
The following are specific embodiments of the present invention, which are presented for the purpose of further describing the invention and are not intended to limit the invention thereto.
Example 1 Amoxicillin capsules and process for preparing the same
Amoxicillin 245g
Magnesium stearate
5g
Drying the amoxicillin raw material with the particle size distribution of D102.56 μm, D507.8 μm and D9020.2 μm by airflow, adding the dried amoxicillin raw material into a dry press for granulation, adjusting the pressure to 60bar, granulating by a granulator, and sieving by a rotary vibration sieve to obtain amoxicillin heavy powder particles; pulverizing magnesium stearate with particle size distribution of D104.2 μm, D5015.7 μm and D9033.8 μm, sieving with a rotary vibrating sieve, and mixing with amoxicillin heavy powder granules in a powder mixing machine; and filling the mixed medicinal powder into capsules by using a capsule filling machine, and preparing into 1000 granules.
EXAMPLE 2 Amoxicillin capsules and method for preparing the same
Amoxicillin 225g
Magnesium stearate 25g
Drying the amoxicillin raw material with the particle size distribution of D105.5 μm, D5013.7 μm and D9033.1 μm by airflow, adding the dried amoxicillin raw material into a dry press for granulation, adjusting the pressure to 1100bar, granulating by a granulator, and sieving by a rotary vibration sieve to obtain amoxicillin heavy powder particles; pulverizing magnesium stearate with particle size distribution of D106.1 μm, D5020.4 μm and D9049.7 μm, sieving with a rotary vibrating sieve, and mixing with amoxicillin heavy powder granules in a powder mixing machine; and filling the mixed medicinal powder into capsules by using a capsule filling machine, and preparing into 1000 granules.
EXAMPLE 3 Amoxicillin capsules and method for preparing the same
247.5g of Amoxicillin
Magnesium stearate 2.5g
Drying the amoxicillin raw material with the particle size distribution of D106.8 μm, D5017.0 μm and D9044.7 μm by airflow, adding the dried amoxicillin raw material into a dry press for granulation, adjusting the pressure to 150bar, granulating by a granulator, and sieving by a rotary vibration sieve to obtain amoxicillin heavy powder particles; pulverizing magnesium stearate with particle size distribution of D1012.5 μm, D5023.3 μm and D9043.3 μm, sieving with a rotary vibration sieve, and mixing with amoxicillin heavy powder granules in a powder mixing machine; and filling the mixed medicinal powder into capsules by using a capsule filling machine, and preparing into 1000 granules.
Stability test example
The beneficial effects of the technical scheme provided by the invention are illustrated through experiments. The amoxicillin capsules prepared in examples 1-3 were subjected to quality inspection while conducting accelerated tests (test conditions of elevated temperature 40 ℃ C., 6 months). The results are shown in table 1.
TABLE 1 Amoxicillin Capsule quality inspection results (%)
As shown in the results in Table 1, the amoxicillin capsules of the invention have the advantages of no obvious decrease in content and dissolution rate, no obvious increase in polymer and total impurities, and good stability after being accelerated for 6 months.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, so that any simple modification, equivalent change or modification made to the above embodiment according to the technical spirit of the present invention will still fall within the scope of the technical solution of the present invention without departing from the content of the technical solution of the present invention.
Claims (6)
1. An amoxicillin capsule, which is characterized in that: the capsule comprises the following components in parts by weight: 90.0-99.9 parts of amoxicillin and 0.1-10.0 parts of magnesium stearate; wherein the particle size distribution of the amoxicillin is D102.5-7.0 μm, D507.0-20.0 μm and D9012.0-45.0 μm; the particle size distribution of magnesium stearate is D104.0-14.0 μm, D50
15.0-28.0μm，D90 30.0-50.0μm；
The preparation method comprises the following steps: comprises the following steps
(1) And (3) dry granulation: drying an amoxicillin raw material by airflow, adding the dried amoxicillin raw material into a dry press for granulation, granulating by a granulator, and sieving by a rotary vibration sieve to obtain amoxicillin heavy powder granules;
(2) mixing: pulverizing magnesium stearate, sieving with a rotary vibration sieve, adding into a powder mixing machine together with amoxicillin heavy powder particles, and mixing;
(3) filling: filling the mixed medicinal powder into capsules by a capsule filling machine;
wherein: the pressure of the dry press is 60-150 bar.
2. An amoxicillin capsule according to claim 1, characterized in that: the capsule comprises the following components in parts by weight: 96.0-99.5 parts of amoxicillin and 0.5-4.0 parts of magnesium stearate.
3. An amoxicillin capsule according to claim 1 or 2, characterized in that: the particle size distribution of the amoxicillin is D103.0-6.0 μm, D508.0-18.0 μm and D9015.0-40.0 μm; the particle size distribution of magnesium stearate is D106.0-12.0 μm, D5018.0-24.0 μm, and D9037.0-47.0 μm.
4. A process for the preparation of amoxicillin capsules as claimed in any one of claims 1 to 3, characterized in that: comprises the following steps
(1) And (3) dry granulation: drying an amoxicillin raw material by airflow, adding the dried amoxicillin raw material into a dry press for granulation, granulating by a granulator, and sieving by a rotary vibration sieve to obtain amoxicillin heavy powder granules;
(2) mixing: pulverizing magnesium stearate, sieving with a rotary vibration sieve, adding into a powder mixing machine together with amoxicillin heavy powder particles, and mixing;
(3) filling: filling the mixed medicinal powder into capsules by a capsule filling machine;
the pressure of the dry press is 60-150 bar.
5. A process for the preparation of amoxycillin capsules according to claim 4, characterized in that: the pressure of the dry press is 90-130 bar.
6. A process for the preparation of amoxycillin capsules according to claim 4, characterized in that: each unit of preparation of the amoxicillin capsule contains 0.125-0.5 g of amoxicillin.
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| CN201711441039.7A CN107875136B (en) | 2017-12-27 | 2017-12-27 | Amoxicillin medicinal preparation and preparation method thereof |
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| CN107875136B true CN107875136B (en) | 2021-03-05 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107875136B (en) * | 2017-12-27 | 2021-03-05 | 广州白云山医药集团股份有限公司白云山制药总厂 | Amoxicillin medicinal preparation and preparation method thereof |
| CN108578383A (en) * | 2018-06-08 | 2018-09-28 | 安徽安科恒益药业有限公司 | A kind of amoxil capsule and its manufacturing method |
| CN109172539A (en) * | 2018-10-26 | 2019-01-11 | 海口市制药厂有限公司 | A kind of Biomox and its production method and application |
| CN109908104B (en) * | 2019-04-23 | 2021-07-27 | 石药集团中诺药业（石家庄）有限公司 | Amoxicillin capsule and preparation method thereof |
| CN109953971A (en) * | 2019-05-14 | 2019-07-02 | 吉林市吴太感康药业有限公司 | A kind of preparation method of amoxil capsule |
| CN112263569B (en) * | 2020-11-05 | 2022-07-08 | 贝克诺顿(浙江)制药有限公司 | Amoxicillin capsule and preparation method thereof |
| CN112156082A (en) * | 2020-11-16 | 2021-01-01 | 海南海力制药有限公司 | Amoxicillin capsule preparation method and amoxicillin capsule |
| CN113133985A (en) * | 2021-04-16 | 2021-07-20 | 海南通用三洋药业有限公司 | Preparation method of amoxicillin capsule |
| CN113133986A (en) * | 2021-04-21 | 2021-07-20 | 海南通用三洋药业有限公司 | Amoxicillin capsule and preparation method thereof |
| CN113274357B (en) * | 2021-05-28 | 2022-12-27 | 广州白云山医药集团股份有限公司白云山制药总厂 | Amoxicillin medicine and preparation method thereof |
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