CN103070907B - Medicine resistant to poultry coccidiosis and preparation method thereof - Google Patents
Medicine resistant to poultry coccidiosis and preparation method thereof Download PDFInfo
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- CN103070907B CN103070907B CN201210583413.8A CN201210583413A CN103070907B CN 103070907 B CN103070907 B CN 103070907B CN 201210583413 A CN201210583413 A CN 201210583413A CN 103070907 B CN103070907 B CN 103070907B
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Abstract
The invention discloses a medicine resistant to poultry coccidiosis and a preparation method thereof. The medicine resistant to poultry coccidiosis is compounded by a plurality of effective components, which have the mutual synergistic effect and great prevention and treatment effects on coccidiosis; and coccidium infection is frequently accompanied with multi-bacterial infection, and the medicine resistant to poultry coccidiosis comprises the components of honeysuckle, wild chrysanthemum flower, common andrographis herb and eucommia ulmoides, so that the medicine has the coccidium-resistant effect by effectively synergizing with sulfonamides, sulfonamide synergists and antiprotozoal agents, and further expands the antibacterial spectrum, and accordingly the rapid treatment for coccidiosis is facilitated.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind of anti-coccidiosis of domestic fowls medicine and preparation method thereof.
Background technology
Coccidiosis is the parasitic disease being caused by unicellular parasite Amy ear, can cause poultry meat and egg to be produced and occur serious loss.The fresh egg capsule of discharging with the feces that infects poultry there is no appeal, is called " unsporulated oocysts ".These unsporulated oocysts need to carry out Sporogony under suitable temperature, humidity, after 1～2 day, just grow for there being the Sporulated Oocysts of infection ability.Sporulated Oocysts disengages Sporangium after being eaten by susceptible poultry under muscular stomach wearing and tearing.The Sporangium that enters small intestinal with food disengages zygoblast under the effect of trypsin and bile, and zygoblast is invaded enterocyte, forms many merozoites after schizogony.Merozoite row schizogony again, forms many merozoites.Coccidiosis is pathogenic the strongest in the schizogony stage, because polypide breeds repeatedly, destroyed a large amount of intestinal submucosa tissues and blood capillary, a large amount of intestinals that cause are thus lost blood, intestinal epithelial cell considerable damage and secondary infection are to cause infected poultry main causes of death.
The birdss such as chicken, duck, goose, pigeon, Carnis Coturnicis japonicae, peafowl, Ostriches all can infect coccidiosis.Intensive culture field is because stocking density is large, and coccidian oocyst quantity is large and relatively concentrated, is therefore the optimum place that coccidiosis breaks out, and sickness rate is about 50%～70%; Mortality rate 20%～30%, serious harm poultry farming.
Summary of the invention
The object of the present invention is to provide a kind of anti-coccidiosis of domestic fowls medicine and preparation method thereof.
Technical scheme of the present invention is as follows:
An anti-coccidiosis of domestic fowls medicine, comprises the component of following weight portion:
In a preferred embodiment of the invention, described sulfa drugs is sulfamonomethoxine.
In a preferred embodiment of the invention, described sulfa drugs synergist is NSC 408735.
In a preferred embodiment of the invention, described antiprotozoal drug is first nitre file.
Another technical scheme of the present invention is as follows:
A preparation method for anti-coccidiosis of domestic fowls medicine, comprises the steps:
(1) by following weight portion, take each component:
(2) above-mentioned each component is made into after powdery to evenly mixing and obtains described anti-coccidiosis of domestic fowls medicine.
In a preferred embodiment of the invention, described sulfa drugs is sulfamonomethoxine.
In a preferred embodiment of the invention, described sulfa drugs synergist is NSC 408735.
In a preferred embodiment of the invention, described antiprotozoal drug is first nitre file.
The invention has the beneficial effects as follows:
1, anti-coccidiosis of domestic fowls medicine of the present invention forms by multiple active ingredient is composite, and each component has mutual synergism, and coccidiosis is had to good prevention and therapeutic effect.
2, coccidium infection is many infects with many bacterium, the present invention comprises Flos Lonicerae, Flos Chrysanthemi Indici, Herba Andrographis and the Cortex Eucommiae, can effectively work in coordination with sulfa drugs, sulfa drugs synergist and the effect of antiprotozoal drug performance anticoccidial, and further expand antimicrobial spectrum, be conducive to the fast treating of coccidiosis.
The specific embodiment
By the specific embodiment, technical scheme of the present invention is further detailed and is described below.
Embodiment 1
Prepare Flos Lonicerae extract: get 10kg Flos Lonicerae and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains described Flos Lonicerae extract 0.3kg;
Prepare Flos Chrysanthemi Indici extract: get 10kg Flos Chrysanthemi Indici and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains described Flos Chrysanthemi Indici extract 0.3kg;
Prepare Herba Andrographis extract: get 10kg Herba Andrographis and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains described Herba Andrographis extract 0.3kg;
Prepare Cortex Eucommiae extract: get 10kg Cortex Eucommiae section and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains described Cortex Eucommiae extract 0.3kg.
Embodiment 2
By following weight portion, take each component: 70 parts of sulfamonomethoxines, 15 parts of NSC 408735s, 18 parts of metronidazoles, 5 parts of Ascorbyl C pill sheets (vitamin C containing 10%), 5 parts of Flos Lonicerae extracts in embodiment 1,3 parts of Flos Chrysanthemi Indici extracts, 1 part of Herba Andrographis extract, 5 parts of Cortex Eucommiae extract.
After above-mentioned each component is made into powdery, even mixing obtains anti-coccidiosis of domestic fowls medicine of the present invention.
Embodiment 3
By following weight portion, take each component: 80 parts of sulfamonomethoxines, 23 parts of NSC 408735s, 23 parts of metronidazoles, 10 parts of Ascorbyl C pill sheets (vitamin C containing 10%), 10 parts of Flos Lonicerae extracts in embodiment 1,5 parts of Flos Chrysanthemi Indici extracts, 3 parts of Herba Andrographis extracts, 10 parts of Cortex Eucommiae extract.
After above-mentioned each component is made into powdery, even mixing obtains anti-coccidiosis of domestic fowls medicine of the present invention.
Embodiment 4
By following weight portion, take each component: 75 parts of sulfamonomethoxines, 20 parts of NSC 408735s, 20 parts of metronidazoles, 8 parts of Ascorbyl C pill sheets (vitamin C containing 10%), 8 parts of Flos Lonicerae extracts in embodiment 1,4 parts of Flos Chrysanthemi Indici extracts, 2 parts of Herba Andrographis extracts, 8 parts of Cortex Eucommiae extract.
After above-mentioned each component is made into powdery, even mixing obtains anti-coccidiosis of domestic fowls medicine of the present invention.
Embodiment 5
The effect test of anti-coccidiosis of domestic fowls medicine of the present invention:
One, test material
1.1 experimental animals: cock, under non-ball worm environment, brood to 12 ages in days, after pretest inspection non-ball worm egg capsule, weigh, divide into groups.
1.2 test coccidiosis worm strains: eimeria tenella cause of disease.
1.3 trial drugs: sulfamonomethoxine, NSC 408735, metronidazole, and anti-coccidiosis of domestic fowls medicine of the present invention (comprises sulfamonomethoxine 70 weight portions, NSC 408735 15 weight portions, metronidazole 20 weight portions, Ascorbyl C pill sheet 5 weight portions, Flos Lonicerae extract 5 weight portions, Flos Chrysanthemi Indici extract 4 weight portions, Herba Andrographis extract 2 weight portions, Cortex Eucommiae extract 10 weight portions.）。
Two, test method
2.1 test groupings: according to body weight dispersion, test chicken is divided into 7 groups at random, 20 every group, record is starting weight just.1st～5 groups for infecting medication group, and the 6th group for infecting not medication group, and the 7th group for not infecting not medication group.
2.2 infect and administration:
Except the 7th group, other respectively organizes chicken all in 12 age in days oral vaccination coccidian oocyst 2.0*10
5individual/only, and table 1(Chinese poultry resource 31 16 phase of the volume p16 in 2009 in > > that affect with reference to < < gluconic acid on meat chicken production performance and Nutrient Apparent Digestibility) preparation basal diet; 1 ~ 5 group after infecting 48h throw something and feed be mixed with relative medicine basal diet to off-test, and the 6th group and the 7th group of basal diet of only throwing something and feeding.Specifically mixing dose sees the following form.
Duration of test observed and recorded every day is respectively organized mental status, appetite, drinking-water and the feces situation of chicken, and morbidity and the death condition of chicken respectively organized in record, and dead chicken weighs at any time, cuts open and examine and record the cause of death.Gram feces egg capsule output (OPG) of the 6th day after calculating counteracting toxic substances; After counteracting toxic substances the 8th day, test chicken is all weighed, cutd open and kill on an empty stomach, carry out lesion score, measure corresponding test index, measurement result sees the following form.
ACI is curative effect index objective, accurate evaluation anticoccidial drug, calculates, that is: ACI=(the relative weight gain rate+survival rate by the method for Merck & Co., Inc.) * 100-(pathological changes value+egg capsule value).ACI < 120 is invalid, and ACI=120～160 are medium effective, and ACI=160～180 are that drug effect is good, and ACI > 180 is efficient.
After the 6th group (matched group) infects coccidiosis, the 5th day chicken starts to discharge a small amount of hemafecia, the 6th, 7 days, especially the 7th day the most serious, discharge a large amount of hemafecias, spirit is depressed, and necking down is slow-witted vertical, drowsiness, feather is fluffy and disorderly, eats less or does not eat, occur dead, survival rate 65.00%, pathological changes value 33.21, egg capsule value 21.00, anticoccidial index (ACI) is only 84.13, and this shows the success of this test ball insect infection.
As can be seen from the above table, sulfamonomethoxine, NSC 408735, metronidazole all can improve anticoccidial ACI, but effect is far away from composition of medicine of the present invention.The anticoccidial Index A CI of anti-coccidiosis of domestic fowls medicine of the present invention is 194.9, apparently higher than the effect of single (1-3 group) or simply composite (4 groups) medicine, belongs to the combination of Effective Anti coccidiosis.Test confirmation, anti-coccidiosis of domestic fowls medicine of the present invention has good therapeutic effect to coccidiosis of domestic fowls.
The above, be only preferred embodiment of the present invention, therefore can not limit according to this scope of the invention process, the equivalence done according to the scope of the claims of the present invention and description changes and modifies, and all should still belong in the scope that the present invention contains.
Claims (2)
1. an anti-coccidiosis of domestic fowls medicine, is characterized in that: the component by following weight portion forms:
Described sulfa drugs is sulfamonomethoxine, and described sulfa drugs synergist is NSC 408735, and described antiprotozoal drug is first nitre file;
The preparation method of described Flos Lonicerae extract is: extracting honeysuckle adds certain amount of boiling water to soak three times, and each 30min merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains;
The preparation method of described Flos Chrysanthemi Indici extract is: get Flos Chrysanthemi Indici and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains;
The preparation method of described Herba Andrographis extract is: get Herba Andrographis and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains;
The preparation method of described Cortex Eucommiae extract is: get Cortex Eucommiae section and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains.
2. a preparation method for anti-coccidiosis of domestic fowls medicine, is characterized in that: comprise the steps:
(1) by following weight portion, take each component:
Described sulfa drugs is sulfamonomethoxine, and described sulfa drugs synergist is NSC 408735, and described antiprotozoal drug is first nitre file;
(2) above-mentioned each component is made into after powdery to evenly mixing and obtains described anti-coccidiosis of domestic fowls medicine;
The preparation method of described Flos Lonicerae extract is: extracting honeysuckle adds certain amount of boiling water to soak three times, and each 30min merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains;
The preparation method of described Flos Chrysanthemi Indici extract is: get Flos Chrysanthemi Indici and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains;
The preparation method of described Herba Andrographis extract is: get Herba Andrographis and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains;
The preparation method of described Cortex Eucommiae extract is: get Cortex Eucommiae section and add certain amount of boiling water to soak three times, each 30min, merges three water extraction liquid, filtration, concentrated, spraying is dried, and obtains described Cortex Eucommiae extract 0.3kg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201210583413.8A CN103070907B (en) | 2012-12-28 | 2012-12-28 | Medicine resistant to poultry coccidiosis and preparation method thereof |
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| CN201210583413.8A CN103070907B (en) | 2012-12-28 | 2012-12-28 | Medicine resistant to poultry coccidiosis and preparation method thereof |
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| CN103070907B true CN103070907B (en) | 2014-11-12 |
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| CN104083731B (en) * | 2014-07-31 | 2017-05-17 | 山东省滨州畜牧兽医研究院 | Medicament for preventing and treating mixed infection of domestic rabbits as well as preparation method thereof |
| CN105454709A (en) * | 2015-11-24 | 2016-04-06 | 浙江群大饲料科技股份有限公司 | Chinese herbal medicine premix for preventing chicken coccocidiosis |
| CN108524913A (en) * | 2018-05-26 | 2018-09-14 | 谢媛 | A kind of medicine and preparation method thereof of prevention Penaeus Vannmei intestinal bacteria disease |
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| CA857296A (en) * | 1970-12-01 | Davis Michael | Veterinary compositions | |
| GB1108112A (en) * | 1965-03-04 | 1968-04-03 | Wellcome Found | Compositions containing sulphaquinoxaline and diaveridine for use in veterinary medicine |
| JPS49110810A (en) * | 1973-03-02 | 1974-10-22 | ||
| JPH09110810A (en) * | 1995-08-11 | 1997-04-28 | Sumitomo Chem Co Ltd | Production of optical active aminoalcohol compounds |
| CN1102027C (en) * | 1998-08-24 | 2003-02-26 | 张家界大众饲料有限责任公司 | Production method of poultry eucommia feed |
| CN1843364A (en) * | 2006-02-11 | 2006-10-11 | 庄晓峰 | Pharmaceutical for preventing and treating coccidiosis, and its usage method |
| CN101007126B (en) * | 2007-01-23 | 2010-09-01 | 天津生机集团有限公司 | Drug for preventing or treating parasites of avian and its preparation method |
| CN102266346B (en) * | 2011-06-24 | 2012-06-13 | 河南牧翔动物药业有限公司 | Medicament for preventing and controlling coccidiosis |
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