CN104083731B - Medicament for preventing and treating mixed infection of domestic rabbits as well as preparation method thereof - Google Patents
Medicament for preventing and treating mixed infection of domestic rabbits as well as preparation method thereof Download PDFInfo
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- CN104083731B CN104083731B CN201410374976.5A CN201410374976A CN104083731B CN 104083731 B CN104083731 B CN 104083731B CN 201410374976 A CN201410374976 A CN 201410374976A CN 104083731 B CN104083731 B CN 104083731B
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Abstract
The invention belongs to the field of veterinary medicines and particularly discloses a medicament for preventing and treating mixed infection of domestic rabbits as well as a preparation method and application thereof. The medicament for preventing and treating mixed infection of domestic rabbits is prepared from the following raw materials in percentage by weight: 20-40% of curcuma zedoaria extracts, 10-20% of angelica sinensis extracts, 15-25% of herba schizonepetae extracts, 20-30% of sulfamonomethoxine and the balance of auxiliary materials. The medicament for preventing and treating mixed infection of domestic rabbits, disclosed by the invention, is simple in preparation, scientific in compatibility, simple and easily available in raw materials, low in cost, affordable and capable of increasing the flow of arterial blood in the bodies of the domestic rabbits and increasing the amount of leucocytes, has the effects of resisting inflammation, clearing away heat, relieving pain, regulating the immunity function of the domestic rabbits and preventing and treating bacterium, virus and coccidiosis mixed infection of the domestic rabbits, can meet the requirements for safe veterinary medicines and animal-derived food safety guarantee and can be used for effectively reducing antibiotics used in a domestic rabbit breeding process to further reduce drug residues in the bodies of the domestic rabbits.
Description
(1) technical field
The invention belongs to field of veterinary, more particularly to a kind of medicine of preventing and treating rabbit mixed infection and preparation method thereof.
(2) background technology
The large-scale cultivation of rabbit has become the main flow of contemporary rabbit aquaculture, under large-scale cultivation pattern, rabbit
Population density is big, stressors increase, it is easy to cause a rabbit invasion even dead, wherein the antibacterial of rabbit, virus, coccidiosis
Mixed infection have become one of universal and serious disease of a rabbit cultivation farm.The antibacterial of rabbit, virus, coccidiosis mixing
Infection has generation in each province of China, particularly occurred frequently in rabbit cultivation close quarters, and rabbit mixed infection is without obvious season
Section property, can occur throughout the year, it is easy to cause a rabbit invasion even dead.Cause the primary sexual factor of rabbit mixed infection
It is some rabbit viruses, rabbit infection is viral, and particularly after atypia rabbit pestilence, then its immunity degradation is easy to by coccidiosiss
And bacterial infestation, cause the reason for secondary infection, rabbit death to be mostly the bacteremia caused due to antibacterial secondary infection.Rabbit
The treatment difficulty of mixed infection is big, mortality rate is high, and to rabbit raiser great economic loss is brought.At present, rabbit is tackled
The primary treatment scheme of mixed infection is the cephalo-type antibiosis of the astragalus polysaccharidess and treatment bacterial disease for lifting rabbit immunization power
Plain compatibility, program therapeutic effect feeds back throughout the country and differs and easily recur after curing, and rabbit is often due to resistance to
The generation of the property of medicine and cause uncertain therapeutic efficacy to be cut, and the Ministry of Agriculture of China forbidden antiviral Western medicine rabbit cultivation field should
With.Additionally, exploratory stage of the therapy field of at present rabbit mixed infection also in the initial stage, how the object of research is mainly controlled
The bacterial disease and coccidiosis disease of rabbit processed, also seldom relates to the Therapy study of rabbit viral disease, and this gives rabbit
Rehabilitation after mixed infection causes very big technology barrier.
(3) content of the invention
The present invention is in order to make up the deficiencies in the prior art, there is provided one kind prepare simply, compatibility science, low cost, can be straight
Connect be added in feed for rabbit, easy to use, instant effect, the use that antibacterials in rabbit breeding process can be reduced, reduce family
Medicine of preventing and treating rabbit mixed infection of rabbit drug disposition residual and preparation method thereof.
The present invention is achieved through the following technical solutions：
A kind of medicine of preventing and treating rabbit mixed infection, comprises the following raw materials by weight percent：Rhizoma Curcumae extract 20-
40%th, Radix Angelicae Sinensis extract 10-20%, Herba Schizonepetae extract 15-25%, sulfamonomethoxine 20-30%, balance of adjuvant.
The medicine of the preventing and treating rabbit mixed infection, the percentage by weight of its preferred each raw material is：Rhizoma Curcumae extract 30%,
Radix Angelicae Sinensis extract 15%, Herba Schizonepetae extract 20%, sulfamonomethoxine 25% and adjuvant 10%.
The adjuvant is any one in oral glucose, anhydrous glucose, sucrose or Lactose and precipitated calcium carbonate, weight
Matter Calcium Carbonate, powdered rice hulls, plus beneficial powder or the combination of any one in maize cob meal.
The preparation method of the medicine of the preventing and treating rabbit mixed infection, comprises the steps：
By above-mentioned percentage by weight weigh Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, sulfamonomethoxine and
Adjuvant crosses 80-100 mesh sieves after crushing respectively, then by methoxy between Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, sulfanilamide
Pyrimidine and adjuvant mix homogeneously, obtain final product the medicine of the preventing and treating rabbit mixed infection.
Application of the medicine of present invention preventing and treating rabbit mixed infection in preventing and treating rabbit mixed infection.
Usage and dosage：In every 1000 kilogram of feed ratio of 1000 grams of medicine of the present invention, medicine of the present invention is mixed and is in
In rabbit feed, after fully mixing, for rabbit free choice feeding, 5 days are used in conjunction.
The pharmaceutical characteristic of each raw material of the present invention is as follows：
Rhizoma Curcumae extract：It is Rhizoma Curcumae bitter in the mouth, pungent, temperature, Return liver, spleen channel, circulation of qi promoting removing blood stasis, Xiao Ji Zhi Tong, it is pained to cure mainly QI and blood, drink
Food stagnation is stagnant, abdominal distention , abdominal lump of mass in abdomen, traumatic injury.Modern study shows that Rhizoma Curcumae extract primary pharmacological activity composition is cowherb
Art alcohol, methoxyl group ethyl cinnamate, epicurzerenone, curzerene, pyrocurcuzerenone, isocurcumenol, procurcumenol, deoxidation curzerenone
Deng oral rear with antiviral, antibacterial, antineoplastic action, moreover it is possible to make blood flow volume increase, quantity of leucocyte in animal body
Raise, with the effect for adjusting animal body immunologic function；
Radix Angelicae Sinensis extract：Radix Angelicae Sinensis sweet in the mouth, temperature, Return liver, the heart, spleen channel, replenishing and activating blood, moisturize laxation.Cure mainly all Zheng , Disorder of blood deficiency
Abdominal mass knot is poly-, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, intestines are dry and shit is difficult, weight, ulcer sores, injury from falling down after bloody dysentery.Modern study table
It is bright：Radix Angelicae Sinensis extract has promotion body hemopoietic function, suppresses platelet aggregation and antithrombotic, the function of blood fat reducing, to blood
There is treatment with hemopoietic function to adjust；Also there is replenishing and activating blood, the effect of body's immunity and anti-hypoxia is adjusted；
Herba Schizonepetae extract：Herba Schizonepetae acrid in the mouth, tepor, return lung, Liver Channel, wind-dispelling is induced sweat, rash, hemostasis.Cure mainly cold, fever,
Headache, eye itching, cough, laryngopharynx swelling and pain, measles, rubella, carbuncle, sore scabies, epistaxis is spitted blood, and is had blood in stool.Modern study shows：Herba Schizonepetae
The primary pharmacological activity composition of extract is D-menthone, racemization menthone, nepetol, schizonodiol etc., with antiinflammatory, solution
Heat, analgesic activity, and have stronger antibacterial action, there is regulation immunity function to respiratory system, central nervous system；
Sulfamonomethoxine：Sulfamonomethoxine has powerful killing action to antibacterial and coccidiosiss, particularly to ball
The killing effect of worm is particularly evident, and sulfamonomethoxine is orally entered in animal body and absorbs good by animal gastrointestinal tract, and 4 is little
Shi Houda blood peak concentration of drugs, the persistent period is long, and blood eliminates the half-life for 30 hours or so, has to antibacterial in animal intestinal and coccidiosiss
Powerful killing action；Sulfamonomethoxine is 85~90% with the combination rate of plasma protein, and orally entering can after animal body
In being widely distributed in animal tissue's body fluid, blood-cerebrospinal fluid barrier is also can pass through, be conducive to the treatment of animal systemic infection.Sulfanilamide
Between Sulfamonomethoxine main metabolites in animal body equally there is antibacterial activity, and act on rapid, metabolite medicine
Concentration peak followed closely and occur after the concentration peak of medicine of the present invention, and circulation time in vivo will be longer than sulfamonomethoxine, no
Antimicrobial effect is only adds additional, the time of pathogen and medicament contact is also extended, is conducive to the treatment of disease.
The medicine preparation of present invention preventing and treating rabbit mixed infection is simple, and compatibility science, raw material is simple and easy to get, low cost, Jing
Ji is suitable for, and multi-medicament is suitably coordinated, and using its mutual collaboration or resistant function, improves curative effect, to adapt to complicated disease
The treatment of feelings requires that reduce untoward reaction, evident in efficacy persistently absorption is fast, proves effective rapid, by increasing capacitance it is possible to increase arterial blood in rabbit body
Flow, the quantity of leukocyte increasing, and with antiinflammatory, antipyretic, analgesia, the effect for adjusting rabbit body's immunity, between sulfanilamide
Sulfamonomethoxine orally can be widely distributed in animal tissue's body fluid into after animal body, also can pass through blood-cerebrospinal fluid barrier, favorably
In the treatment of animal systemic infection, the metabolite of sulfamonomethoxine equally has antibacterial activity and its metabolite medicine
Concentration peak circulation time in animal body is long, increased antimicrobial effect, extends the time of pathogen and medicament contact, is suitable for
In the needs of rabbit mixed infection preventing and treating；Oral glucose, anhydrous glucose, sucrose or Lactose are added with adjuvant, can be improved
The mouthfeel and palatability of medicine；Can directly be added in feed for rabbit, it is easy to use, have no toxic side effect and drug residue, have
Prevention and treatment rabbit antibacterial, virus, the effect of coccidiosis mixed infection, are that one kind meets safe veterinary drug, ensures animal sources food
The medicine of the preventing and treating rabbit mixed infection of product safety, can effectively reduce the use of antibiotic in rabbit breeding process and then reduce house
Drug residue in rabbit body.
(4) specific embodiment
With reference to embodiment, the invention will be further described, but the invention is not limited in this, the system in embodiment
Preparation Method is customary preparation methods, no longer describes in detail.
Embodiment 1：(weight is as follows in terms of double centner)
The medicine of the preventing and treating rabbit mixed infection, is made up of the raw material of following weight：30 kilograms of Rhizoma Curcumae extract, Radix Angelicae Sinensis are carried
Take 15 kilograms of thing, 20 kilograms of Herba Schizonepetae extract, 25 kilograms of sulfamonomethoxine, 6 kilograms of oral glucose and add beneficial powder 4,000
Gram；
The preparation method of the medicine of the preventing and treating rabbit mixed infection, using following steps：
Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, sulfamonomethoxine, oral Portugal are weighed by above-mentioned weight
Grape are sugared and add beneficial powder to cross 80-100 mesh sieves after crushing respectively, then by Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, sulphur
Sulfamonomethoxine between amine, oral glucose and add beneficial powder mix homogeneously, obtain final product the medicine of the preventing and treating rabbit mixed infection.
Usage and dosage：In every 1000 kilogram of feed ratio of 1000 grams of medicine of the present invention, medicine of the present invention is mixed and is in
In rabbit feed, after fully mixing, for rabbit free choice feeding, 5 days are used in conjunction.
Embodiment 2：
The medicine of the preventing and treating rabbit mixed infection, is made up of the raw material of following weight：
20 kilograms of Rhizoma Curcumae extract, 10 kilograms of Radix Angelicae Sinensis extract, 25 kilograms of Herba Schizonepetae extract, sulfamonomethoxine 30,000
Gram, 8 kilograms of 7 kilograms of anhydrous glucose and powdered rice hulls.
Preparation method is with usage and dosage with embodiment 1.
Embodiment 3：
The medicine of the preventing and treating rabbit mixed infection, is made up of the raw material of following weight：
40 kilograms of Rhizoma Curcumae extract, 20 kilograms of Radix Angelicae Sinensis extract, 15 kilograms of Herba Schizonepetae extract, sulfamonomethoxine 20,000
Gram, 3 kilograms of 2 kilograms of sucrose and precipitated calcium carbonate.
Preparation method is with usage and dosage with embodiment 1.
Embodiment 4：
The medicine of the preventing and treating rabbit mixed infection, is made up of the raw material of following weight：
25 kilograms of Rhizoma Curcumae extract, 18 kilograms of Radix Angelicae Sinensis extract, 17 kilograms of Herba Schizonepetae extract, sulfamonomethoxine 23,000
Gram, 8 kilograms of 9 kilograms of Lactose and maize cob meal.
Preparation method is with usage and dosage with embodiment 1.
Embodiment 5：
The medicine of the preventing and treating rabbit mixed infection, is made up of the raw material of following weight：
35 kilograms of Rhizoma Curcumae extract, 13 kilograms of Radix Angelicae Sinensis extract, 22 kilograms of Herba Schizonepetae extract, sulfamonomethoxine 27,000
Gram, 1 kilogram of 2 kilograms of oral glucose and ground calcium carbonate.
Preparation method is with usage and dosage with embodiment 1.
Rhizoma Curcumae extract used, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, sulfamonomethoxine, oral Portugal in embodiment 1-5
Grape sugar, anhydrous glucose, sucrose, Lactose, precipitated calcium carbonate, ground calcium carbonate, powdered rice hulls, plus beneficial powder, maize cob meal be city
Sell product.
In order to verify clinical treatment curative effect of the medicine of the present invention to rabbit mixed infection, the present inventor in September, 2013 extremely
In May, 2014 has carried out therapeutic test in the rabbit that different family's rabbit cultivation farms is fallen ill to mixed infection using medicine of the present invention,
It is specific as follows：
Treatment example 1：
Shandong Province Accessories during Binzhou meat rabbit plant, cultivate meat rabbit more than 800, meat rabbit occur successively diarrhoea, abdominal distention, cough,
Spirit is depressed, body temperature rises high symptom, and Jing clinical diagnosises are mixed infection.
Using the medicine of the made preventing and treating rabbit mixed infection of the embodiment of the present invention 1, by every 1000 kilogram of feed present invention
The ratio that 1000 grams of medicine, medicine of the present invention is mixed in meat rabbit feed, after fully mixing, for meat rabbit free choice feeding, is used in conjunction 5
My god.
After medication 2 days, ill meat rabbit situation takes a turn for the better, and after continuing medication 3 days, rabbit group's each side recovering state is normal.
Treatment example 2：
There is cough, rhinorrhea, spiritual depressed, body temperature in rex rabbit plant of Weifang City of Shandong Province, 830 rex rabbit morbidities
High symptom is risen, Jing clinical diagnosises are mixed infection.
Using the medicine of the made preventing and treating rabbit mixed infection of the embodiment of the present invention 2, by every 1000 kilogram of feed present invention
The ratio that 1000 grams of medicine, medicine of the present invention is mixed in beaver rabbit feed, after fully mixing, for rex rabbit free choice feeding, is used in conjunction 5
My god.
After medication 2 days, ill rex rabbit situation takes a turn for the better, and after continuing medication 3 days, rex rabbit group's each side recovering state is normal.
Treatment example 3：
Become mildewed rabbit cultivation farm for Linyi, there is Pili in Fetus of Haired Rabbit 2000, and rabbit group lassitude, appetite occurs successively and subtracts
The phenomenon moved back, nares have serosity, mucus or purulence nose liquid, accelerated breathing, occasionally there is sneeze, and body temperature is increased to 40-
41 DEG C, discharge of eye increases, diarrhoea, perianal and hind leg faecal contamination, and sick rabbit is front on one's deathbed asthma occurs, head layback, entirely
Body trembles, tic of the limbs symptom, and cut open inspection is shown in nasal cavity, larynx, trachea-bronchial epithelial cell mucous hyperemia, bleeding, inside has volume serosity, glues
Liquid or purulent secretion, lungs hyperemia, bleeding, the stagnation of the blood have volume pustule, and surface and tangent plane are scattered with many canescence, Semen Glyciness
Big pus sample tuberosity focus, Jing clinical diagnosises are atypical bacteria hemorrhagic disease and bordetella bacilli and coccidiosis mixed infection.
Using the medicine of the made preventing and treating rabbit mixed infection of the embodiment of the present invention 4, by every 1000 kilogram of feed present invention
The ratio that 1000 grams of medicine, medicine of the present invention is mixed in feedstuff for long-hair rabbits, after fully mixing, for Pili in Fetus of Haired Rabbit free choice feeding, is connected
With 5 days.
After medication 3 days, ill Pili in Fetus of Haired Rabbit situation takes a turn for the better, and after continuing medication 2 days, rabbit group's each side recovering state is normal.
Treatment example 4：
The foster rabbit specialty in Linyi raises on a household basis rabbit 336, in March, 2014 morbidity, starts to behave as loss of appetite,
Feces are yellow, white, Lycoperdon polymorphum Vitt loose stool, and the gluey sample material that has having is discharged, and body temperature is normal, and death is started after 2-3 days, big with celebrating
Mycin is failed to respond to any medical treatment.Cut open inspection is carried out to 3 dead rabbits, it is seen that stomach expands, full of a large amount of liquids and gases；Intestinal is full of gas
Body, liquid or gel-shaped liquid；Small intestinal mucosa has bleeding, hyperemia, intestinal serosa congestion, bleeding, edema, caecum mucosa is congested,
Bleeding；Liver enlargement has small point-like necrosis region, and gallbladder is filled；Heart, kidney are showed no ANOMALOUS VARIATIONS.According to epidemiology, face
Bed symptom and pathological anatomical change are diagnosed as coccidiosis and colibacillosiss mixed infection.
Using the medicine of the made preventing and treating rabbit mixed infection of the embodiment of the present invention 5, by every 1000 kilogram of feed present invention
The ratio that 1000 grams of medicine, medicine of the present invention is mixed in feed for rabbit, after fully mixing, for rabbit free choice feeding, is used in conjunction 5
My god.
2-3 days future trouble patient and his family's rabbit symptoms of medication disappear substantially, and spirit, appetite have been recovered, and feces also recover normal；Medication
To the 5th day, ill rabbit symptom was wholly absent, and spirit, appetite recover normal, no longer occurred not eating, tripe swollen, the clinical condition such as have loose bowels
Shape, urine and feces it is also normal.
Claims (2)
1. a kind of medicine of preventing and treating rabbit mixed infection, is characterized in that：Comprise the following raw materials by weight percent：Rhizoma Curcumae is extracted
Thing 20-40%, Radix Angelicae Sinensis extract 10-20%, Herba Schizonepetae extract 15-25%, sulfamonomethoxine 20-30%, supplemented by surplus
Material；The adjuvant is any one in oral glucose, anhydrous glucose, sucrose or Lactose and precipitated calcium carbonate, heavy carbon
Sour calcium, powdered rice hulls, plus beneficial powder or the combination of any one in maize cob meal；Preparation method is：Claim by above-mentioned percentage by weight
Take and cross after Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, sulfamonomethoxine and adjuvant are crushed respectively 80-100 mesh
Sieve, then by Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, sulfamonomethoxine and adjuvant mix homogeneously, obtains final product this
The medicine of preventing and treating rabbit mixed infection.
2. a kind of medicine of preventing and treating rabbit mixed infection according to claim 1, is characterized in that：By following percentage by weight
Raw material composition：Rhizoma Curcumae extract 30%, Radix Angelicae Sinensis extract 15%, Herba Schizonepetae extract 20%, the and of sulfamonomethoxine 25%
Adjuvant 10%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410374976.5A CN104083731B (en) | 2014-07-31 | 2014-07-31 | Medicament for preventing and treating mixed infection of domestic rabbits as well as preparation method thereof |
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| CN104083731B true CN104083731B (en) | 2017-05-17 |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104523887A (en) * | 2014-12-25 | 2015-04-22 | 北京资源亚太饲料科技有限公司 | Pharmaceutical composition for preventing and treating respiratory tract diseases of fur-bearing animals and preparation method and application of pharmaceutical composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062171A (en) * | 2007-05-18 | 2007-10-31 | 湛江市第一兽药厂 | Method for producing bacterial virus element medicine for preventing bacterial virus mixed infection for critter, fowl and aquatic animals |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006040816A1 (en) * | 2004-10-13 | 2006-04-20 | Kabushiki Kaisha Yakult Honsha | Additive for feeds and feed containing the same |
| CN101450055A (en) * | 2007-11-29 | 2009-06-10 | 天津瑞普生物技术集团有限公司 | Soluble powder for treating livestock and poultry bacterial infection and parasitic disease |
| CN101428125B (en) * | 2008-12-19 | 2011-06-29 | 成都青山利康药业有限公司 | Medicament composition with antiviral efficacy |
| CN103070907B (en) * | 2012-12-28 | 2014-11-12 | 漳州师范学院 | Medicine resistant to poultry coccidiosis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062171A (en) * | 2007-05-18 | 2007-10-31 | 湛江市第一兽药厂 | Method for producing bacterial virus element medicine for preventing bacterial virus mixed infection for critter, fowl and aquatic animals |
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Effective date of registration: 20151109 Address after: 256618 No. nine, No. 480, Bohai Road, Shandong, Binzhou Applicant after: Binzhou, Shandong Province animal and veterinary research institute Address before: 256600 No. three, No. 510, the Yellow River Road, Shandong, Binzhou Applicant before: Liu Jishan |
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