CN1843364A - Pharmaceutical for preventing and treating coccidiosis, and its usage method - Google Patents
Pharmaceutical for preventing and treating coccidiosis, and its usage method Download PDFInfo
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- CN1843364A CN1843364A CN 200610042338 CN200610042338A CN1843364A CN 1843364 A CN1843364 A CN 1843364A CN 200610042338 CN200610042338 CN 200610042338 CN 200610042338 A CN200610042338 A CN 200610042338A CN 1843364 A CN1843364 A CN 1843364A
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Abstract
The invention relates to a pharmaceutical composition for preventing and treating coccidiosis and method of use, it is found that the combination of trimethoprim diaveridine with sulfonamides can produce evident synergism to sulphonamides and reduce the consumption of sulphonamides, the anti-drug tolerance of can also be improved.
Description
Technical field
The present invention relates to the medicine of a kind of prevention and treatment coccidiosis, and the using method of this medicine.
Background technology
Coccidiosis is a kind of general disease of culturing carnivore, and it is to be caused by Eimeria, and causes damage of intestines, diarrhoea, enteritis and death.Coccidiosis is a kind of disease that influences economic benefit in livestock and poultry cultivation, even very not serious infection also can cause the minimizing that feed efficiency descends and weight increases, coccidium infection is known to be the inducement of other syndrome, particularly necrotic enteritis.
Coccidiosis is the important parasite disease that serious harm animal husbandry is produced.More typical birds, chicken for example, it is by 7 kinds of intestinal parasitical diseases that coccidiosis causes of Eimeria, mainly betides for 3 monthly ages with interior chicken, the chickling sickness rate of 15-50 age in days is the highest, this disease takes place, its infection rate 50-70%, mortality rate 20-30% in the broiler of especially raising in warm, wet environment easily, severe patient is up to 80%, causing enormous economic loss to poultry husbandry, is one of the expensive and the most general disease in producing of raising chickens, and accounts for the 1/5-1/6 of total fowl disease.Almost we can say have the place of chicken that coccidiosis is just arranged, do not taking just the popular of chicken coccidiosis will inevitably to take place under the situation of effective preventive measure.Whole world every year because of coccidiosis cause with a toll of 2,000,000,000 pounds.The expenses for prevention and control that China is used for chicken coccidiosis every year is several hundred million RMB.And, the loss that the economic loss that the decline of subclinical type infection poultry production power is caused is brought much larger than clinical type coccidiosis.The persistent infection of small intestinal coccidiosis, coccidiosis and necrotic enteritis be mixed to infect, have during the caecum coccidiosis break out, to occur in a large number be that popular main feature takes place current coccidiosis to the strain of drug resistance worm.
Along with improving constantly of China's poultry husbandry intensification degree, the harm of coccidiosis will be serious all the more.Should we have than past more more method now and removed to control coccidiosis; But coccidiosis still is, and is a major issue concerning animal health and economic benefit with continuing.Its main cause comprises: (1) our uncontrollable all factors that cause coccidiosis burst; (2) economic benefit of aquaculture is to the influence of disease control.
At present, chemoprophylaxis and treatment remain the main means of control coccidiosis, and people are generally by adding the eruption and prevalence that various anticoccidial drugs prevent coccidiosis in feedstuff.We can say there is not the development of anticoccidial drug, just do not have the poultry husbandry of today, the development of these medicines and be applied as the control chicken coccidiosis strong weapon is provided.The correct use of anticoccidial drug is very important, is the basic assurance of guaranteeing to give full play to anticoccidial effect.In a single day chicken house breaks out coccidiosis, the treatment of medication immediately.Although medication this moment is ineffective to the serious chicken that falls ill, and still is useful to disease controlling.Medicine reply second filial generation schizogony and gametogonia stage are effective, and preferably water miscible.Because of when being in a bad way, the loss of appetite of chicken even useless exhausted, but still can drink water.The anticoccidial drug that belongs to this class mainly contains that hundred balls are clear, sulfaclozine sodium, water solublity Amprolium, sodium sulfaquinoxaline etc., is that chicken house must standing anticoccidial drug.
Because the unusual fertility of coccidiosis, egg capsule is propagated by feces and straw in a mattress, but also can pass through air borne, for example propagates by the motion of dust with by carrier organism such as Lumbricus, beetle, fly and other insect.Present known coccidiosis control method comprises the use coccidiostat, puts it into feedstuff and can offer the animal that is prevented and treat easily.Typical medicine comprises sulfonamides coccidiosis chemical synthetic drug.But along with the frequency that uses increases, the organism of treatment produces certain drug resistance to this medicine.
For improving the curative effect of sulfonamides coccidiosis, people attempt to make the composite anti-coccidium medicine with adding a certain amount of medicament synergistic agent in the medicine.But in practice, this compound medicine storage period weak point causes caking easily, and drug effect descends greatly, must use immediately just to reach synergic purpose.Moreover this compound medicine can not be water-soluble fully, can not give the poultry dispenser by the mode of drinking water.
Summary of the invention
Technical problem to be solved by this invention provides a kind of synergic and suitable poultry are drunk or the medicine of a kind of prevention edible, evident in efficacy and treatment coccidiosis.
Simultaneously, the present invention also provides the using method of said medicine.
For achieving the above object, technical scheme of the present invention is: the medicine of a kind of prevention and treatment coccidiosis, comprise coccidiostat and medicament synergistic agent, it is characterized in that: described coccidiostat is the sulfonamides coccidiostat, and described medicament synergistic agent is a dimethoxy benzyl Aminometradine; Described coccidiostat and described medicament synergistic agent barrier packaging.
As a kind of technical scheme, described sulfonamides coccidiostat is sodium sulfaquinoxaline or sulfaclozine sodium.
As a kind of technical scheme, the using method of said medicine is at first used water dissolution with the sodium sulfaquinoxaline or the sulfaclozine sodium of barrier packaging in an independent container, simultaneously dimethoxy benzyl Aminometradine is also used water dissolution in an independent container; Then said medicine and medicament synergistic agent are mixed with the form of drinking for poultry, fowl.
As a kind of technical scheme, the using method of said medicine, at first get the sodium sulfaquinoxaline or the sulfaclozine sodium of a certain amount of barrier packaging, get a certain amount of dimethoxy benzyl Aminometradine simultaneously, then said medicine and medicament synergistic agent are mixed with for poultry, the edible form of fowl as feed additive.
Because adopt technique scheme, trimethoprim (TMP)-dimethoxy benzyl Aminometradine and sulfonamides share, and sulfonamides is had obvious synergistic effect, and can reduce the consumption of sulfonamides, have improved the anti-drug resistance of sulfonamides coccidiostat.Because the absorption for oral administration of dimethoxy benzyl Aminometradine is less, in digestive tract, keep higher concentration, so cooperate sulphonamides to be used for the effect of enterobacterial infection, coccidiosis of livestock and poultry significantly better than simple sulfa drugs; Described coccidiostat and described medicament synergistic agent barrier packaging have solved dimethoxy benzyl Aminometradine and can not dissolve, be difficult for the technical barrier of long-term storage fully with the mixture that coccidiostat is mixed in water; Improved the pharmaceutical effectiveness that dimethoxy benzyl Aminometradine and sulfa drugs are used greatly.
The specific embodiment
Embodiment one: the medicine of a kind of prevention and treatment coccidiosis, comprise coccidiostat and medicament synergistic agent, and described coccidiostat is a sodium sulfaquinoxaline; Described medicament synergistic agent is a dimethoxy benzyl Aminometradine; Described coccidiostat and described medicament synergistic agent barrier packaging.
Specifically, when producing,, be packaged in two packaging bags respectively and seal, be put into the packaging bag separately of two kinds of medicines in the packaging bag that is printed on description then and seal sodium sulfaquinoxaline and dimethoxy benzyl Aminometradine.During use, with two in packaging bag bag medicine, be dissolved in respectively in the low amounts of water and (be about 5～10 liters), the solution sulphaquinoxaline sodium solution and dimethoxy benzyl Aminometradine is blended into together; The mixed solution of sodium sulfaquinoxaline and dimethoxy benzyl Aminometradine, add clear water to the explanation amount then, drink for poultry according to explanation.
Certainly, described medicine also can use following method: sodium sulfaquinoxaline or the sulfaclozine sodium of at first getting a certain amount of barrier packaging, get a certain amount of dimethoxy benzyl Aminometradine simultaneously, then said medicine and medicament synergistic agent are mixed with for poultry, the edible form of fowl as feed additive.
Through overtesting, dimethoxy benzyl Aminometradine and sodium sulfaquinoxaline share in 1: 3～5 ratios, have obvious synergistic effect, and can reduce the consumption of sodium sulfaquinoxaline, improve the anti-drug resistance of sodium sulfaquinoxaline coccidiostat.
Embodiment two: the medicine of a kind of prevention and treatment coccidiosis, comprise coccidiostat and medicament synergistic agent, and described coccidiostat is a sulfaclozine sodium; Described medicament synergistic agent is a dimethoxy benzyl Aminometradine; Described coccidiostat and described medicament synergistic agent barrier packaging.
Specifically, when producing,, be packaged in two packaging bags respectively and seal, be put into the packaging bag separately of two kinds of medicines in the packaging bag that is printed on description then and seal sulfaclozine sodium and dimethoxy benzyl Aminometradine.During use, with two in packaging bag bag medicine, be dissolved in respectively in the low amounts of water and (be about 5～10 liters), the solution sulfaclozine sodium solution and dimethoxy benzyl Aminometradine is blended into together; The mixed solution of sulfaclozine sodium and dimethoxy benzyl Aminometradine, add clear water to the explanation amount then, drink for poultry according to explanation.
Certainly, described medicine also can use following method: the sulfaclozine sodium of at first getting a certain amount of barrier packaging, get a certain amount of dimethoxy benzyl Aminometradine simultaneously, then said medicine and medicament synergistic agent are mixed with for poultry, the edible form of fowl as feed additive.
Through overtesting, dimethoxy benzyl Aminometradine and sulfaclozine sodium share in 1: 3～5 ratios, have obvious synergistic effect, and can reduce the consumption of sulfaclozine sodium, improve the anti-drug resistance of sulfaclozine sodium coccidiostat.
Claims (4)
1. a medicine that prevents and treat coccidiosis comprises coccidiostat and medicament synergistic agent, and it is characterized in that: described coccidiostat is the sulfonamides coccidiostat, and described medicament synergistic agent is a dimethoxy benzyl Aminometradine; Described coccidiostat and described medicament synergistic agent barrier packaging.
2. the medicine of a kind of prevention as claimed in claim 1 and treatment coccidiosis, it is characterized in that: described sulfonamides coccidiostat is sodium sulfaquinoxaline or sulfaclozine sodium.
3. as the using method of medicine as described in the claim 2, it is characterized in that: at first the sodium sulfaquinoxaline or the sulfaclozine sodium of barrier packaging are used water dissolution in an independent container, simultaneously dimethoxy benzyl Aminometradine is also used water dissolution in an independent container; Then said medicine and medicament synergistic agent are mixed with the form of drinking for poultry, fowl.
4. as the using method of medicine as described in the claim 2, it is characterized in that: sodium sulfaquinoxaline or the sulfaclozine sodium of at first getting a certain amount of barrier packaging, get a certain amount of dimethoxy benzyl Aminometradine simultaneously, then said medicine and medicament synergistic agent are mixed with for poultry, the edible form of fowl as feed additive.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 200610042338 CN1843364A (en) | 2006-02-11 | 2006-02-11 | Pharmaceutical for preventing and treating coccidiosis, and its usage method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610042338 CN1843364A (en) | 2006-02-11 | 2006-02-11 | Pharmaceutical for preventing and treating coccidiosis, and its usage method |
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| CN1843364A true CN1843364A (en) | 2006-10-11 |
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| CN 200610042338 Pending CN1843364A (en) | 2006-02-11 | 2006-02-11 | Pharmaceutical for preventing and treating coccidiosis, and its usage method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188435A (en) * | 2011-02-12 | 2011-09-21 | 中牧南京动物药业有限公司 | Compound sulfaclozine sodium suspension and preparation method thereof |
| CN103070907A (en) * | 2012-12-28 | 2013-05-01 | 漳州师范学院 | Medicine resistant to poultry coccidiosis and preparation method thereof |
-
2006
- 2006-02-11 CN CN 200610042338 patent/CN1843364A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188435A (en) * | 2011-02-12 | 2011-09-21 | 中牧南京动物药业有限公司 | Compound sulfaclozine sodium suspension and preparation method thereof |
| CN102188435B (en) * | 2011-02-12 | 2012-08-29 | 中牧南京动物药业有限公司 | Compound sulfaclozine sodium suspension and preparation method thereof |
| CN103070907A (en) * | 2012-12-28 | 2013-05-01 | 漳州师范学院 | Medicine resistant to poultry coccidiosis and preparation method thereof |
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