CN108992448A - A kind of ornamental fish saliferous degerming tablet and preparation method thereof - Google Patents
A kind of ornamental fish saliferous degerming tablet and preparation method thereof Download PDFInfo
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- CN108992448A CN108992448A CN201811090627.5A CN201811090627A CN108992448A CN 108992448 A CN108992448 A CN 108992448A CN 201811090627 A CN201811090627 A CN 201811090627A CN 108992448 A CN108992448 A CN 108992448A
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Abstract
The invention discloses a kind of ornamental fish saliferous degerming tablets and preparation method thereof, belong to field of Chinese herbal.Above-mentioned ornamental fish is made of with saliferous degerming tablet following parts by weight of component: cultivation special-purpose salt 10-30 parts, 10-20 parts of multi-vitamins, 40-60 parts of composite mineral matter, 1-20 parts of methyl blue, 1-20 parts of malachite green, 5-15 parts of drug, 1-10 parts of filler, 1-10 parts of adhesive, 1-10 parts of lubricant, 1-10 parts of gas-producing disintegrant.Ornamental fish prepared by the present invention has preferable therapeutic effect to mushroom and parasite type with saliferous degerming tablet, and rapid-action, and function and effect are good；Preparation method is simple simultaneously, and tablet is readily transported, and is suitble to large-scale promotion application.
Description
Technical field
The present invention relates to culture of ornamental fish technical fields, are specifically to provide a kind of ornamental fish saliferous degerming tablet and its system
Preparation Method.
Background technique
Ornamental fish refers to the fish for having bright colors or fancy shapes with ornamental value, because its is lucuriant in design, by
People's likes.But during nursing, because of improper feeding, it is sick or generate various defects, shadow to will lead to fish
Ring its ornamental value.
In the prior art, when carrying out related disinfection and treatment to ornamental fish, choice drug is exactly salt, adds salt
Certain sterilization and prevention effect can be played, still, the fish for having existed illness is acted on smaller.In the prior art, about
It can cure the disease and diseases prevention and the bacteria-removing liquid sterilized to water body also have relevant report.
Patent CN102550609A discloses a kind of sterilization liquid for aquaculture of marine organisms, can be used for aquaculture process
In, the treatment and prevention and treatment of the bacteriosis common to the ginseng of cultivation, fish, shrimp, crab simultaneously can be used for the purification of breeding water body
With disinfection.99.999% or more is reached to the degerming rate of all kinds of pathogenic bacterias bred in breeding process, to cultivation crop without
Malicious, non-stimulated, not mutagens, while sterilization can be played the role of to breeding water body, there is long-acting bacteriostatic, can effectively safeguard water body
Environment reduces the pathogenic chance of material culture.Simple production process, cost price is low, no pollution to the environment.But the production of the invention
Product can only prevent and treat related disease, also need additionally to add related nutritional ingredient, guarantee healthy fish growth, while the invention
Product be liquid, transport difficult.
Summary of the invention
The present invention provides a kind of ornamental fish saliferous degerming tablet and preparation method thereof, and the present invention is specifically formulated can be fast
Fast efficiently treatment fish proposes disease, while can effectively prevent the generation of harmful substance, while adding related vitamin and minerals
Element guarantees healthy fish growth.
In order to solve the above technical problems, present invention offer technical solution is as follows:
The present invention provides a kind of ornamental fish saliferous degerming tablet, is made of following parts by weight of component:
Special-purpose salt 10-30 parts of cultivation
10-20 parts of multi-vitamins
40-60 parts of composite mineral matter
1-20 parts of methyl blue
1-20 parts of malachite green
5-15 parts of drug
1-10 parts of filler
1-10 parts of adhesive
1-10 parts of lubricant
1-10 parts of gas-producing disintegrant.
Preferably, above-mentioned ornamental fish is made of with saliferous degerming tablet following parts by weight of component:
Special-purpose salt 20-30 parts of cultivation
15-20 parts of multi-vitamins
50-60 parts of composite mineral matter
10-20 parts of methyl blue
10-20 parts of malachite green
10-15 parts of drug
5-10 parts of filler
5-10 parts of adhesive
5-10 parts of lubricant
5-10 parts of gas-producing disintegrant.
Preferably, above-mentioned ornamental fish is made of with saliferous degerming tablet following parts by weight of component:
25 parts of special-purpose salt of cultivation
20 parts of multi-vitamins
55 parts of composite mineral matter
15 parts of methyl blue
10 parts of malachite green
15 parts of drug
8 parts of filler
10 parts of adhesive
10 parts of lubricant
8 parts of gas-producing disintegrant.
Further, the drug is trichomonas net and/or furazolidone, and the two uses simultaneously, weight ratio 1:1；It is described
The weight ratio of methyl blue and malachite green is 1.5:1.
Trichomonas net is broad spectrum antibiotic, and Antibacterial Mechanism is the DNA synthesis for inhibiting thallus, and trichomonas net has most of bacteriums
There is very strong inhibiting effect.Gram-negative bacteria is acted on stronger.Meanwhile trichomonas net safety is good, takes orally and absorbs well.To fish
The bacillary hemorrhage of muscle of class, gill cover bleeding, fin ray bleeding, bleeding of skin and visceral hemorrhage have special efficacy.To various fish enteritis, rotten
The bacteriosis such as the gill, red skin, perpendicular squama, expophthalmos ascites have a better effect.
Furazolidone has certain antibacterial action to Grain-positive and negative bacterium, detection of Salmonella, shigella dysenteriae, Escherichia coli,
Proteus, streptococcus and staphylococcus etc. have antibacterial action.Bacterium is not likely to produce drug resistance to furazolidone, with sulfanilamide (SN) and
Antibiotic is also without cross resistance.There is preferable effect to the fish enteritis and gill rot of fish.
Methyl blue draws fish ichthyophthirius, saprolegniasis, mouth silk floss, fried squama, rotten tail, gill rot, white mouth and oblique tube insect, Gyrodactylus
The diseases such as the skin disease risen, have preferable therapeutic effect, wherein the therapeutic effect for saprolegniasis is best.
Malachite green can administer the helminth, fungi or bacterium infection of fish or fish-egg, have special efficacy to saprolegniasis.Peacock
The fresh water aquatic products that malachite green is influenced also highly useful as processing by helminth.
The present invention is using trichomonas net and furazolidone as main component, using methyl blue and malachite green as auxiliary element, four
Collective effect can effectively treat and prevent the disease generated during the culture of ornamental fish.
Preferably, the multi-vitamins are at least two in vitamin A, vitamine D3 and vitamin B2；It is described multiple
Conjunction minerals are at least two in medical stone, bentonite and zeolite.
General fish body cannot synthesize vitamin, but vitamin plays significant role in the metabolic process of fish, lack dimension
Raw element can cause dysbolism, generate deficiency disease.Meanwhile mineral matter element is critically important to the nutrition of fish, can effectively tie up
Hold the osmotic balance between fish body liquid and surrounding water.But addition can excessively cause fish slow poisoning, mineral matter element is excessive
The triumph activity that can inhibit enzyme, changes the activity of large biological molecule, right so as to cause fish in form, physiology and the variation of behavior
Fish growth is unfavorable.Vitamin and mine needed for the present invention provides growth by addition multi-vitamins and composite mineral matter for fish
Material element guarantees deficiency disease will not be caused to occur because vitamin and mineral element lacks in growth course.
Preferably, the filler is one or more of starch, dextrin, microcrystalline cellulose.
Preferably, described adhesive is the ethanol solution of the concentration 18wt%-20wt% of PEG4000 or PEG6000.
Preferably, the lubricant is one or more of ethyl alcohol, calcium stearate and lauryl sodium sulfate.
Further, the gas-producing disintegrant is the mixture of sodium bicarbonate and citric acid that mass ratio is 1:1.2-1.5.
The present invention also provides a kind of preparation methods of above-mentioned ornamental fish saliferous degerming tablet, comprising:
Step 1: special-purpose salt, multi-vitamins, composite mineral matter, methyl blue, malachite green, drug, filler, lubrication will be cultivated
Agent, gas-producing disintegrant crush, and cross 80-100 mesh；
Step 2: adhesive is added, granulation, 50 DEG C of dryings, tabletting is up to ornamental fish saliferous degerming tablet.
Further, every 5-10g of tablet when for preventing, launches 1 in every 50L water body, launched every 3 days primary；
When treating sick body fish, every 1Kg fish launches 0.5g tablet prepared by the present invention and continuous 4-6 days, then switchs to again 1 time a day
Preventative dispensing.
Compared with prior art, the invention has the following advantages:
The present invention provides a kind of ornamental fish saliferous degerming tablet and preparation method thereof, with trichomonas net and furazolidone be mainly at
Point, using methyl blue and malachite green as auxiliary element, can killing bacterium rapidly and efficiently, while the production of disease can be prevented
It is raw；The present invention also contains multi-vitamins and composite mineral matter, provides related nutritional substance for fish growth, prevents deficiency disease
It generates；The present invention is prepared into tablet, convenient transportation, and preparation method is simple, is suitable for large-scale promotion and uses.
Specific embodiment
To keep the technical problem to be solved in the present invention, technical solution and advantage clearer, specific embodiment will be used below
It is described in detail, but the present invention is limited to absolutely not these examples.The following is only the preferred embodiment of the present invention, is only used to
Explain the present invention, it cannot be construed as a limitation to the scope of the present invention.It should be pointed out that all of the invention
Any modifications, equivalent replacements, and improvements etc. done within spirit and principle, should all be included in the protection scope of the present invention.
Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Except specified otherwise, component used in the present invention is commercial product.
The present invention provides a kind of ornamental fish saliferous degerming tablet and preparation method thereof, and specific embodiment is as follows.
Embodiment 1
A kind of ornamental fish saliferous degerming tablet, is made of following parts by weight of component:
10 parts of special-purpose salt of cultivation
10 parts of vitamin A
10 parts of vitamine D3
20 parts of medical stone
20 parts of bentonite
20 parts of methyl blue
1 part of malachite green
15 parts of trichomonas net
10 parts of dextrin
1 part of 18wt%PEG4000 ethanol solution
1 part of ethyl alcohol
0.45 part of sodium bicarbonate
0.55 part of citric acid.
Embodiment 2
A kind of ornamental fish saliferous degerming tablet, is made of following parts by weight of component:
30 parts of special-purpose salt of cultivation
2 parts of vitamin A
4 parts of vitamine D3
4 parts of vitamin B2
20 parts of medical stone
25 parts of bentonite
15 parts of zeolite
1 part of methyl blue
20 parts of malachite green
5 parts of furazolidone
1 part of starch
10 parts of the ethanol solution of 18wt%PEG6000
10 parts of calcium stearate
4.5 parts of sodium bicarbonate
5.5 parts of citric acid.
Embodiment 3
A kind of ornamental fish saliferous degerming tablet, is made of following parts by weight of component:
20 parts of special-purpose salt of cultivation
8 parts of vitamin A
6 parts of vitamine D3
6 parts of vitamin B2
20 parts of medical stone
30 parts of zeolite
20 parts of methyl blue
10 parts of malachite green
7.5 parts of trichomonas net
7.5 parts of furazolidone
10 parts of microcrystalline cellulose
10 parts of the ethanol solution of 20wt%PEG6000
10 parts of lauryl sodium sulfate
2.25 parts of sodium bicarbonate
2.75 parts of citric acid.
Embodiment 4
A kind of ornamental fish saliferous degerming tablet, is made of following parts by weight of component:
30 parts of special-purpose salt of cultivation
4 parts of vitamin A
7 parts of vitamine D3
4 parts of vitamin B2
10 parts of medical stone
30 parts of bentonite
20 parts of zeolite
10 parts of methyl blue
20 parts of malachite green
5 parts of trichomonas net
5 parts of furazolidone
2 parts of starch
3 parts of dextrin
10 parts of the ethanol solution of 20wt%PEG4000
3 parts of calcium stearate
2 parts of lauryl sodium sulfate
4.5 parts of sodium bicarbonate
5.5 parts of citric acid.
Embodiment 5
A kind of ornamental fish saliferous degerming tablet, is made of following parts by weight of component:
25 parts of special-purpose salt of cultivation
10 parts of vitamin A
8 parts of vitamine D3
7 parts of vitamin B2
15 parts of medical stone
20 parts of bentonite
20 parts of zeolite
15 parts of methyl blue
10 parts of malachite green
7.5 parts of trichomonas net
7.5 parts of furazolidone
4 parts of dextrin
4 parts of microcrystalline cellulose
10 parts of the ethanol solution of 20wt%PEG46000
3 parts of ethyl alcohol
2 parts of calcium stearate
5 parts of lauryl sodium sulfate
3.6 parts of sodium bicarbonate
4.4 parts of citric acid.
Embodiment 6
A kind of ornamental fish saliferous degerming tablet, is made of following parts by weight of component:
22 parts of special-purpose salt of cultivation
6 parts of vitamin A
6 parts of vitamine D3
6 parts of vitamin B2
20 parts of medical stone
20 parts of bentonite
16 parts of zeolite
18 parts of methyl blue
12 parts of malachite green
6 parts of trichomonas net
6 parts of furazolidone
3 parts of dextrin
5 parts of microcrystalline cellulose
7 parts of the ethanol solution of 20wt%PEG46000
1 part of ethyl alcohol
3 parts of calcium stearate
5 parts of lauryl sodium sulfate
3.6 parts of sodium bicarbonate
4.4 parts of citric acid.
The present invention also provides a kind of preparation methods of above-mentioned ornamental fish saliferous degerming tablet, comprising:
Step 1: special-purpose salt, multi-vitamins, composite mineral matter, methyl blue, malachite green, drug, filler, lubrication will be cultivated
Agent, gas-producing disintegrant crush, and cross 80-100 mesh；
Step 2: adhesive is added, granulation, 50 DEG C of dryings, tabletting is up to ornamental fish saliferous degerming tablet.
Every 5-10g of tablet when for preventing, launches 1 in every 50L water body, launched every 3 days primary；Treat sick body
When fish, every 1Kg fish launches 0.5g tablet prepared by the present invention and continuous 4-6 days, then switchs to again preventative 2 times a day
It launches.
It is the effect for further proving ornamental fish saliferous degerming tablet prepared by the present invention, only with reality because length is limited
Building comparative example is as follows for applying example 5.
Comparative example 1
This comparative example omits multi-vitamins, remaining component and dosage are same as Example 5.
Comparative example 2
This comparative example omits composite mineral matter, remaining component and dosage are same as Example 5.
Comparative example 3
This comparative example omits methyl blue, remaining component and dosage are same as Example 5.
Comparative example 4
This comparative example omits malachite green, remaining component and dosage are same as Example 5.
Comparative example 5
This comparative example omits methyl blue and malachite green, remaining component and dosage are same as Example 5.
Comparative example 6
This comparative example omits trichomonas net, remaining component and dosage are same as Example 5.
Comparative example 7
This comparative example omits furazolidone, remaining component and dosage are same as Example 5.
Comparative example 8
This comparative example omits trichomonas net and furazolidone, remaining component and dosage are same as Example 5.
Comparative example 9
This comparative example omits multi-vitamins and furazolidone, remaining component and dosage are same as Example 5.
Above-mentioned comparative example 1-6 preparation and application is identical as the method provided by the present invention.
It include myxobacter, fluorescent pole to Common Fish by above-described embodiment 1-6 and comparative example 1-9 tablet prepared
Hair bacillus etc. mushrooms and the control efficiency of the insects such as small melonworm, oblique tube insect is detected.
With the glass aquarium of 16 100L that are filled with water, the tap water through being sufficiently aerated is loaded onto, utilizes siphon in experimentation
Method is removed contamination, and changes water twice, and each quantity of exchanged water is the 1/5 of total Water, and 20-28 DEG C of water temperature, pH is 7 or so, is used for breeding goldfish.
The goldfish for phenomena such as screening goldfish obtains fish body nigrescence, and mouth is congested, the gill is pale, and scale falls off, analyzes through dissect and sends out
It is now red skin, enteritis and gill rot as caused by pseudomonas fluorescens, dotted production gas pseudomonas bacillus and myxobacter mixed infection.It will be certainly
The goldfish so to fall ill is placed into above-mentioned aquarium, 50 in each glass aquarium.It is thrown in 15 aquariums thereto respectively
The pharmaceutical chemistry of the tablet containing 1-6 of the embodiment of the present invention and comparative example 1-9 preparation is put, the concentration of tablet prepared by the present invention is pharmaceutical chemistry
1.5%, feed daily 2 times, be changed to after 6 days every 3 days launch 2；Another aquarium is arranged to control group, launches equivalent bait
Material, but it is free from tablet of the invention.
Fish body observation in above-mentioned aquarium is fed to the 1st day, the 3rd day, the 6th day, the 9th day, the 15th day and the 30th day
Fish body death and survival condition are shown in Table 1.
Table 1
As shown in Table 1, degerming tablet prepared by the present invention causes pseudomonas fluorescens, dotted production gas pseudomonas bacillus and myxobacter
The illnesss such as red skin, enteritis and gill rot have preferable function and effect.Compared with comparative example, 1-6 of embodiment of the present invention preparation
Tablet, just plays the role of preferable on day 1, and at generally on earth 6 days, there is no fish death, can preferably control illness；Comparison
In example 1-9, the certain ingredients reduced in the present invention can also play the role of sterilization compared with the control group, but it is relatively slow to take effect,
Fish death is also had successively, and the death rate is significantly larger than the tablet of preparation of the embodiment of the present invention, it was demonstrated that only the present invention is complete
It is formulated while acting on, it is best to the therapeutic effect of above-mentioned illness.
The tablet prepared to the embodiment of the present invention and comparative example prevents effect from detecting helminth: each aquarium
In be put into 50 goldfish, carry out helminth (insects such as small melonworm, oblique tube insect) infection experiment, in experimentation, thrown in every 50L water
1 is put, is launched within every 3 days primary；Control group does not launch any medicament, and observing effect is shown in Table 2.
Table 2
As shown in Table 2, degerming tablet prepared by the present invention has preferable function and effect to eliminating fish parasites.Compared with comparative example,
The tablet of 1-6 of embodiment of the present invention preparation, cure rate is 90% or more；In comparative example 1-9, reduce the present invention in it is certain at
Point, compared with the control group, also it can play a role, but cure rate is well below tablet prepared by the embodiment of the present invention,
It proves there was only the complete formula of the present invention while act on, it is best to the therapeutic effect of above-mentioned illness.
To sum up, ornamental fish prepared by the present invention has preferable treatment effect to mushroom and parasite type with saliferous degerming tablet
Fruit, and it is rapid-action, and function and effect are good；Preparation method is simple simultaneously, and tablet is readily transported, and is suitble to large-scale promotion application.
The above is a preferred embodiment of the present invention, it is noted that for those skilled in the art
For, without departing from the principles of the present invention, it can also make several improvements and retouch, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of ornamental fish saliferous degerming tablet, which is characterized in that be made of following parts by weight of component:
Special-purpose salt 10-30 parts of cultivation
10-20 parts of multi-vitamins
40-60 parts of composite mineral matter
1-20 parts of methyl blue
1-20 parts of malachite green
5-15 parts of drug
1-10 parts of filler
1-10 parts of adhesive
1-10 parts of lubricant
1-10 parts of gas-producing disintegrant.
2. ornamental fish according to claim 1 saliferous degerming tablet, which is characterized in that by following parts by weight of component group
At:
Special-purpose salt 20-30 parts of cultivation
15-20 parts of multi-vitamins
50-60 parts of composite mineral matter
10-20 parts of methyl blue
10-20 parts of malachite green
10-15 parts of drug
5-10 parts of filler
5-10 parts of adhesive
5-10 parts of lubricant
5-10 parts of gas-producing disintegrant.
3. ornamental fish according to claim 2 saliferous degerming tablet, which is characterized in that by following parts by weight of component group
At:
25 parts of special-purpose salt of cultivation
20 parts of multi-vitamins
55 parts of composite mineral matter
15 parts of methyl blue
10 parts of malachite green
15 parts of drug
8 parts of filler
10 parts of adhesive
10 parts of lubricant
8 parts of gas-producing disintegrant.
4. ornamental fish according to claim 1 to 3 saliferous degerming tablet, which is characterized in that the drug is dysentery bacterium
Net and/or furazolidone；The weight ratio of the methyl blue and malachite green is 1.5:1.
5. ornamental fish according to claim 4 saliferous degerming tablet, which is characterized in that the multi-vitamins are dimension life
At least two in plain A, vitamine D3 and vitamin B2；The composite mineral matter be medical stone, bentonite and zeolite in extremely
It is two kinds few.
6. according to the saliferous degerming tablet of the ornamental fish described in claim 5, which is characterized in that the filler be starch, dextrin,
One or more of microcrystalline cellulose.
7. according to the saliferous degerming tablet of the ornamental fish described in claim 5, which is characterized in that described adhesive be PEG4000 or
The ethanol solution of the concentration 18wt%-20wt% of PEG6000.
8. according to the saliferous degerming tablet of the ornamental fish described in claim 5, which is characterized in that the lubricant is ethyl alcohol, tristearin
One or more of sour calcium and lauryl sodium sulfate.
9. according to the saliferous degerming tablet of the ornamental fish described in claim 5, which is characterized in that the gas-producing disintegrant is mass ratio
For the sodium bicarbonate of 1:1.2-1.5 and the mixture of citric acid.
10. the preparation method of any ornamental fish saliferous degerming tablet of claim 1-9 characterized by comprising
Step 1: special-purpose salt, multi-vitamins, composite mineral matter, methyl blue, malachite green, drug, filler, lubrication will be cultivated
Agent, gas-producing disintegrant crush, and cross 80-100 mesh；
Step 2: adhesive is added, granulation, 50 DEG C of dryings, tabletting is up to ornamental fish saliferous degerming tablet.
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