CN101647469A - Compound quaternary ammonium salt disinfectant liquid and preparation method thereof - Google Patents
Compound quaternary ammonium salt disinfectant liquid and preparation method thereof Download PDFInfo
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- CN101647469A CN101647469A CN200910307411A CN200910307411A CN101647469A CN 101647469 A CN101647469 A CN 101647469A CN 200910307411 A CN200910307411 A CN 200910307411A CN 200910307411 A CN200910307411 A CN 200910307411A CN 101647469 A CN101647469 A CN 101647469A
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Abstract
The invention relates to a compound quaternary ammonium salt disinfectant liquid, which is prepared by compounding single-double chain quaternary ammonium salt benzalkonium bromide and didodecyl dimethyl ammonium chloride used as raw components and povidone-iodine, dissolving the three components by using ethanol with the concentration of 95 percent as a solvent and mixing evenly. The compound quaternary ammonium salt disinfectant liquid comprises the following components by weight percent: 0.2-0.6 percent of benzalkonium bromide, 5-15 percent of didodecyl dimethyl ammonium chloride, 5-13 percent of povidone-iodine, 25-35 percent of ethanol with the concentration of 95 percent, and the balance of purified water. The implementation steps are as follows: (1), weighing benzalkonium bromide, didodecyl dimethyl ammonium chloride and povidone-iodine according to the proportion and placing into a container; (2), weighing the ethanol with the proportional concentration of 95 percent into the container; and (3) sufficiently and evenly mixing the components in the steps (1) and (2) to be dissolved, fixing volume by using purified water, separately packaging and checking according to the routine, and warehousing the qualified products. The invention has the advantages of simple preparation, safe use, no toxicity, no pollution for environment, stable medicine property and obvious effect.
Description
Technical field
The present invention relates to a kind of compound disinfectant and preparation method thereof, particularly a kind of compound quaternary ammonium salt disinfectant liquid and preparation method thereof.
Background technology
The production of current China, operation and most popular disinfection drug for animals are mainly compound phenols, iodine class, quaternary ammonium salts and chlorinated product four big classes.Still there are a lot of problems in actual applications in disinfectant for animals, as, ignore organic matters such as removing the interior ight soil of livestock and poultry house, food-residue, body surface cast; Think that the disinfection of drinking water agent is harmless and arbitrarily strengthen concentration to livestock and poultry, cause damage; Think and use warm boiling water to do the Disinfection Effect that solvent can increase all disinfectants; Can not accomplish cross-application polytype disinfectant, cause chemical sproof generation; Think that the disinfectant smell is dense more good more, cause the livestock and poultry mucosa injury, influence benefit.
In production practices, because the situation more complicated is more and more higher to the requirement of disinfectant.Test confirms merely to use single chemicals disinfectant can not satisfy the requirement of good biological safety program; Single disinfectant all exists some intrinsic defectives: penetrates a little less than the organic matter ability, and influenced by ambient temperature big, working concentration height, more and more serious safety problem, the forfeiture of price advantage etc.Have only just can the assemble a crowd chief of family of composite disinfection agent, reach the requirement of comprehensive organism safety program.When there are (excrement, urine, earth etc.) in organic matter, pathogenic microorganism quantity is big, kind is many, and temperature, humidity change greatly, and it is different to be sterilized article surface structure, and water quality (hardness, acid-base value) is when difference is big, and composite disinfectant is the ideal selection.
Therefore, provide a kind of antimicrobial efficiency height, effect rapidly, good stability, to human body nonhazardous, environmentally safe, anti-organic matter disturbs, cost is lower, security performance is high compound quaternary ammonium salt disinfectant liquid and preparation method thereof, will be one of current urgent problem of these those skilled in the art.
Summary of the invention
The objective of the invention is to overcome the prior art weak point, provide that a kind of effect is remarkable, widely used compound quaternary ammonium salt disinfectant liquid and preparation method thereof.
The technical solution adopted in the present invention is for achieving the above object:
A kind of compound quaternary ammonium salt disinfectant liquid, comprise that with single double-chain quaternary ammonium salt class benzalkonium bromide, two ten alkyl-dimethyl ammonium chlorides be main component and the mutually composite compound quaternary ammonium salt disinfectant liquid of povidone iodine, described three kinds of compositions are to dissolve under the effect of solvent at concentration 95% ethanol, mix to form; Described various composition proportion % by weight is: benzalkonium bromide 0.2-0.6%, two ten alkyl-dimethyl ammonium chloride 5-15%, povidone iodine 5-13%, concentration are that 95% ethanol 25-35%, surplus are purified water.
Described various composition optimal components ratio % by weight is: benzalkonium bromide 0.4%, two ten alkyl-dimethyl ammonium chlorides 10%, povidone iodine 9%, concentration are that 95% ethanol 30%, surplus are purified water.
A kind of preparation method of compound quaternary ammonium salt disinfectant liquid, concrete implementation step is as follows:
(1) takes by weighing benzalkonium bromide, two ten alkyl-dimethyl ammonium chlorides, povidone iodine in described ratio and put into the container mixing;
(2) taking by weighing described proportional concentration is that 95% ethanol is put into said vesse;
(3) composition that step (1), (2) are comprised carries out abundant mixing, makes its dissolving, uses the purified water constant volume then; Carry out packing more routinely, check, warehousing after passing.
After this compound component is mixed by a certain percentage,, thereby improved sterilization effect greatly by its synergistic characteristic energy killing bacteria gemma.Therefore contain multiple composition in the compound disinfectant, and, the ratio of each component content is reduced relatively, reduced side effects such as toxicity to the people, excitant effectively with single, double chain quaternary ammonium salt use in conjunction.
Main points of the present invention are to select suitable component, and carry out rationally composite, through weigh, dissolving, mixing, filtration, packing, add a cover, technology such as packing forms compound quaternary ammonium salt disinfectant liquid.
The outstanding effect of compound quaternary ammonium salt disinfectant liquid of the present invention is:
(1) uses liquor strength low, generally use one thousandth can reach bactericidal action.
(2) sterilization, bactericidal range is wide, is suitable for the antibiotic and sterilizing of every field, industry-by-industry, various article.
(3) antibiotic and sterilizing is effective, and is harmless to the article of being sterilized.
(4) safe in utilization, nontoxic, environmentally safe, and stable in properties.
(5) good product performance, price are low, easy to use, but wide popularization and application.
Its main component of compound quaternary ammonium salt disinfectant liquid of the present invention comprises benzalkonium bromide, two ten alkyl-dimethyl ammonium chlorides, and povidone iodine, ethanol is mixed into compound disinfectant in proportion.This thimerosal can be used for the antibiotic and sterilizing of various industries, every field, various article, it belongs to pharmaceutically a kind of novel wide spectrum, efficient, environment-friendly type disinfecting liquid, be the outstanding representative of compound quaternary ammonium salt disinfectant liquid of the 5th generation, solved China's medical and health services industry, food and medicine processing industry, livestock-raising and butchered the drawback of using traditional thimerosal to expose in industry and the healthy epidemic prevention of household person.In a word, compound quaternary ammonium salt disinfectant liquid is a kind of novel desirable environment-friendly type disinfecting liquid.
Embodiment
Below in conjunction with preferred embodiment, to details are as follows according to embodiment provided by the invention:
Embodiment 1 (percentage by weight %)
Take by weighing by weight percentage:
Benzalkonium bromide 0.2,
Two ten alkyl-dimethyl ammonium chlorides 5,
Povidone iodine 5,
Concentration 95% ethanol (by weight) 25,
Purified water adds to 100.
Concrete implementation step is as follows:
(1) takes by weighing benzalkonium bromide, two ten alkyl-dimethyl ammonium chlorides, povidone iodine in described ratio and put into the container mixing;
(2) taking by weighing described proportional concentration is that 95% ethanol is put into said vesse;
(3) composition that step (1), (2) are comprised carries out abundant mixing, makes its dissolving, uses the purified water constant volume, carries out packing more routinely, check, warehousing after passing.
Embodiment 2
Take by weighing by weight percentage:
Benzalkonium bromide 0.4,
Two ten alkyl-dimethyl ammonium chlorides 10,
Povidone iodine 9,
Concentration 95% ethanol 30,
Purified water adds to 100.
Preparation method and other are with embodiment 1.
Embodiment 3
Take by weighing by weight percentage:
Benzalkonium bromide 0.6,
Two ten alkyl-dimethyl ammonium chlorides 15,
Povidone iodine 13,
Concentration 95% ethanol 35,
Purified water adds to 100.
Preparation method and other are with embodiment 1.
Compound quaternary ammonium salt disinfectant liquid using method of the present invention:
The compound quaternary ammonium salt disinfectant liquid of getting above-mentioned (embodiment 2) preparation is an amount of, and after the dilution, drinking-water, spraying, immersion are used, and are generally action time 1-10 minute, and concrete operations are as follows:
1, routine disinfection and environment disinfected 1: 2000-3000 spray.
2, eqpidemic disease phase sterilization 1: 400-600 sprays.
3, plant the egg sterilization soaks at 1: 1500.
Wash away in the house when 4, sky is given up and instrument sterilization 1: 2500-3500 sprays.
5, drinking-water or band fowl poultry steam fog sterilization 1: 600-1000 drinking-water or spraying.
6, mouthful hoof, breast bubble, fester, wound disinfection smears at 1: 200.
7, infectious disease emergence period 1: 1500-2500 spraying.
Above-mentioned detailed description of compound quaternary ammonium salt disinfectant liquid and preparation method thereof being carried out with reference to embodiment; be illustrative rather than determinate; can exemplify out several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound quaternary ammonium salt disinfectant liquid, it is characterized in that comprising that with single double-chain quaternary ammonium salt class benzalkonium bromide, two ten alkyl-dimethyl ammonium chlorides be main component and the mutually composite compound quaternary ammonium salt disinfectant liquid of povidone iodine, described three kinds of compositions are to dissolve under the effect of solvent at concentration 95% ethanol, mix to form; Described various composition proportion % by weight is: benzalkonium bromide 0.2-0.6%, two ten alkyl-dimethyl ammonium chloride 5-15%, povidone iodine 5-13%, concentration are that 95% ethanol 25-35%, surplus are purified water.
2. compound quaternary ammonium salt disinfectant liquid according to claim 1, it is characterized in that described various composition optimal components ratio by weight % be: benzalkonium bromide 0.4%, two ten alkyl-dimethyl ammonium chlorides 10%, povidone iodine 9%, concentration are that 95% ethanol 30%, surplus are purified water.
3. the preparation method of a compound quaternary ammonium salt disinfectant liquid according to claim 1 and 2 is characterized in that concrete implementation step is as follows:
(1) takes by weighing benzalkonium bromide, two ten alkyl-dimethyl ammonium chlorides, povidone iodine in described ratio and put into the container mixing;
(2) taking by weighing described proportional concentration is that 95% ethanol is put into said vesse;
(3) composition that step (1), (2) are comprised carries out abundant mixing, makes its dissolving, uses the purified water constant volume then; Carry out packing more routinely, check, warehousing after passing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910307411A CN101647469A (en) | 2009-09-22 | 2009-09-22 | Compound quaternary ammonium salt disinfectant liquid and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910307411A CN101647469A (en) | 2009-09-22 | 2009-09-22 | Compound quaternary ammonium salt disinfectant liquid and preparation method thereof |
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| CN101647469A true CN101647469A (en) | 2010-02-17 |
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| CN200910307411A Pending CN101647469A (en) | 2009-09-22 | 2009-09-22 | Compound quaternary ammonium salt disinfectant liquid and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335197A (en) * | 2010-07-23 | 2012-02-01 | 北京施耐克生物制药有限公司 | Disinfector of skin and mucous membranes for inactivating viruses |
| CN102488705A (en) * | 2011-12-08 | 2012-06-13 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
| CN102600496A (en) * | 2012-01-30 | 2012-07-25 | 施耐克江苏生物制药有限公司 | I, II and III medical equipment products acting on skin, mucosa and wound for inactivating virus |
| CN103109861A (en) * | 2011-11-16 | 2013-05-22 | 洛阳惠中兽药有限公司 | Iodine-containing disinfectant |
| CN106804620A (en) * | 2016-11-30 | 2017-06-09 | 河池市技术开发中心 | A kind of disinfection of tools for silkworm rearing liquid containing quaternary ammonium salt |
| CN112273382A (en) * | 2020-08-03 | 2021-01-29 | 吴丹 | High-solubility compound disinfectant |
| CN112314640A (en) * | 2020-08-03 | 2021-02-05 | 吴丹 | Compound disinfectant with high adsorption performance |
| CN115777706A (en) * | 2023-02-02 | 2023-03-14 | 山东宏润空压机科技有限公司 | Concentrated quaternary ammonium salt disinfectant for oral cavity pipeline and preparation method thereof |
-
2009
- 2009-09-22 CN CN200910307411A patent/CN101647469A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102335197A (en) * | 2010-07-23 | 2012-02-01 | 北京施耐克生物制药有限公司 | Disinfector of skin and mucous membranes for inactivating viruses |
| CN102335197B (en) * | 2010-07-23 | 2013-08-14 | 北京施耐克生物制药有限公司 | Disinfector of skin and mucous membranes for inactivating viruses |
| CN103109861A (en) * | 2011-11-16 | 2013-05-22 | 洛阳惠中兽药有限公司 | Iodine-containing disinfectant |
| CN103109861B (en) * | 2011-11-16 | 2015-01-07 | 洛阳惠中兽药有限公司 | Iodine-containing disinfectant |
| CN102488705A (en) * | 2011-12-08 | 2012-06-13 | 施耐克江苏生物制药有限公司 | Skin mucous membrane disinfectant for killing virus |
| CN102600496A (en) * | 2012-01-30 | 2012-07-25 | 施耐克江苏生物制药有限公司 | I, II and III medical equipment products acting on skin, mucosa and wound for inactivating virus |
| CN102600496B (en) * | 2012-01-30 | 2014-06-04 | 施耐克江苏生物制药有限公司 | I, II and III medical equipment products acting on skin, mucosa and wound for inactivating virus |
| CN106804620A (en) * | 2016-11-30 | 2017-06-09 | 河池市技术开发中心 | A kind of disinfection of tools for silkworm rearing liquid containing quaternary ammonium salt |
| CN112273382A (en) * | 2020-08-03 | 2021-01-29 | 吴丹 | High-solubility compound disinfectant |
| CN112314640A (en) * | 2020-08-03 | 2021-02-05 | 吴丹 | Compound disinfectant with high adsorption performance |
| CN115777706A (en) * | 2023-02-02 | 2023-03-14 | 山东宏润空压机科技有限公司 | Concentrated quaternary ammonium salt disinfectant for oral cavity pipeline and preparation method thereof |
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Application publication date: 20100217 |