CN102293199A - Disinfectant and preparation method thereof - Google Patents
Disinfectant and preparation method thereof Download PDFInfo
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- CN102293199A CN102293199A CN2011101076733A CN201110107673A CN102293199A CN 102293199 A CN102293199 A CN 102293199A CN 2011101076733 A CN2011101076733 A CN 2011101076733A CN 201110107673 A CN201110107673 A CN 201110107673A CN 102293199 A CN102293199 A CN 102293199A
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- deionized water
- thimerosal
- cocinic acid
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- potassium hydroxide
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Abstract
The invention relates to a disinfectant and a preparation method thereof. The disinfectant formula comprises the following components by weight percent: 5.0-7.0% of p-chloro-m-xylenol, 6.5-9.5% of coconut acid, 3.7-5.4% of potassium hydroxide, 15.0-25.0% of isopropanol, 3.0-6.0% of pine oil and the balance of deionized water. The preparation method comprises the following steps: (1) adding deionized water and potassium hydroxide, stirring, and heating to 90 DEG C-100 DEG C, and adding cocinic acid, so as to prepare potassium cocinin soap; and (2) mixing p-chloro-m-xylenol with isopropanol, heating for dissolving, adding the deionized water and the potassium cocinin soap, then stirring, cooling to 30 DEG C-35 DEG C, adding pine oil, stirring, replenishing the deionized water and continuing stirring so as to obtain the disinfectant. By using the disinfectant provided by the invention, 99.999% of enteropathogen, pyogenic coccus and saccharomytes can be killed; and the preparation method is simple, low in cost and suitable for industrial production.
Description
Technical field
The invention belongs to the disinfectant technical field, particularly relate to a kind of thimerosal and preparation method thereof.
Background technology
Microorganism is very extensive in distributed in nature, comprises water, soil, air and human body skin surface, and a large amount of microbial profile is all arranged, and a lot of pathogenic bacteria are wherein just arranged.
Target microorganism is multiplied and is bred, and can cause the article harm such as rotten, wound infection, communicate illness of going rotten.The kinsfolk once took place to account for 82.1% with infected by microbes diseases associated family in 1 year according to investigations, and it is relevant to comprise that the numerous disease domestic articles pollutes.
Domestic and international home disinfecting liquid product, commonly used was the thimerosal of clorox and Peracetic acid in the past, these thimerosals have low price, bactericidal effect rapidly and efficiently and generally uses, their defective also clearly simultaneously: stimulate infringement skin and respiratory mucosa, cause that metal gets rusty, corrosives, band yarn dyed fabric bleaching decolourization; Serious may cause skin burn; Also be easy in addition decompose, poor stability, general storage life has only some months.Because the problems referred to above cause production, transportation, storage and use that many potential safety hazards and inconvenience are arranged.
Summary of the invention
Technical problem to be solved by this invention provides a kind of thimerosal and preparation method thereof, and the bactericidal effect of this thimerosal is good, effective bacteriostasis rate 99.999%, and the holding time is long; And the preparation method is simple, and cost is low, is suitable for suitability for industrialized production.
A kind of thimerosal prescription of the present invention, its component be, parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water, its percentage by weight be,
5.0-7.0: 6.5-9.5: 3.7-5.4: 15.0-25.0: 3.0-6.0: surplus.
The pH value of the mixed liquor that described thimerosal prescription is formed is in the alkalescent scope.
The component of described thimerosal prescription is, parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water, and its percentage by weight is 6.0-6.5: 7.0-9.0: 4.0-5.0: 18.0-20.0: 4.0-5.0: surplus.
The preparation method of a kind of thimerosal of the present invention comprises:
(1) adds deionized water and potassium hydroxide, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, make the cocinic acid potash soap, leave standstill 6-8 hour sample examination, defective allotment is to qualified (qualified standard working substance content 〉=30%, free alkali content≤0.03%);
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving adds deionized water and above-mentioned cocinic acid potash soap again, stirs; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add deionized water and continue to stir, promptly; Standard total solid substance 〉=7.5% that semi-finished product are qualified, pH≤10.
The percentage by weight of the parachlorometaxylenol in wherein above-mentioned, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is, 5.0-7.0: 6.5-9.5: 3.7-5.4: 15.0-25.0: 3.0-6.0: surplus, described deionized water are the total amount in above-mentioned two steps.
Cocinic acid limit edged in the described step (1) stirs, and feeds intake to finish back continuation stirring 60-70 minute.
Thimerosal of the present invention is applicable to textile disinfecting, general surface disinfection.
The using method of thimerosal of the present invention:
1, textile disinfecting: get 48 milliliters and add 2.5 premium on currency, valid density is 0.09% (w/v), is used for underwear, coat, socks etc. and soaks 3-5 minute, and swimsuit, Children's diaper, napkin, towel etc. soaked 5 minutes.
2, floor, household surface sterilization: get 60 milliliters and add 1.25 premium on currency, valid density is 0.22% (w/v), is used to clean the cleaning piece surface 3-5 minute.
3, sterilization lavatory, tank, irrigation canals and ditches, litter-bin: smear or wiping 5 minutes with stoste.
The term of validity: 2 years.
The fill a prescription mechanism of action of each composition
1, parachlorometaxylenol (PCMX) is mainly as bactericide
PCMX belongs to the halogenated phenols compound, and halogenation can improve the sterilizing ability of phenols, but has reduced toxicity and excitant.PCMX has safe and efficient, broad-spectrum antiseptic bactericidal activity is all killed effect to multiple microorganism.
PCMX bactericidal action mechanism: cracking and penetration cell wall, make the bacterium protein sex change, making the main enzyme of microorganism is inactivation, and then changes the cell permeability of the membrane, causes the seepage failure of cell membrane, stops the active matter transportation, metabolite is piled up, thereby makes thalline death.
PCMX is dissolved in ethanol and alkaline aqueous solution, is slightly soluble in water, and 20 solvability when spending are 0.003% to be soluble in organic solvents such as alcohol, ether, polyethylene glycol, and solvability, stability are better in anion surfactant.
2, pine-tree oil is an auxiliary agent, and being used for removing has bacterial peculiar smell.
3, isopropyl alcohol is that organic solvent is used to dissolve PCMX in process of production.
4, cocinic acid is used to prepare the cocinic acid potash soap, and thimerosal will have certain clean result.The cocinic acid potash soap is main washing material, belongs to the anion surfactant class.Soluble in water and the alcohol organic solvent of cocinic acid potash soap, the ability of stronger wetting, infiltration, dispersion and decontamination.
5, potassium hydroxide is used for and cocinic acid.PCMX is dissolved in weakly alkaline solution, when preparation cocinic acid potash soap, certain free alkali is arranged, and helps dissolubility and the bactericidal properties of PCMX.PH fixes in the weak base scope.
6, deionized water is a solvent.
With PCMX is the thimerosal of main sterilization component, can be used for the sterilization of skin and mucous membrane, clothing sterilization, the sterilization of household crust etc., has broad-spectrum high-efficiency and low-toxicity, safe ready, and the advantage that efficiency time is long, and be used widely.This series products to human temperature and, the non-oxidation discoloration, though there is certain smell pungent, corrosivity is little, stable in properties, but long term storage have satisfied the security requirement that the agent of people's home disinfecting is used, thereby are subjected to mass consumption person's welcome.This series products is in the fast-developing phase at present.
Parachlorometaxylenol is along with the rising bactericidal action of the increase of concentration, the prolongation of action time, temperature strengthens, and this sterilization rule with general chemosterilant is consistent.In certain pH value scope, disinfectant can raise with the Ph value of solution, and bactericidal effect reduces.Organic matter has certain influence to disinfectant.
Table 1PCMX minimal inhibitory concentration (MIC)
| Microorganism | Minimal inhibitory concentration (MIC) (ppm) |
| Pseudomonas aeruginosa Pseudomonas aeruginosa | 1000 |
| Salmonella Salmonella entiritidis | 100 |
| Escherichia coli Escherichia coli | 50 |
| Staphylococcus aureus Staphylococcus aureus | 10 |
| Black-koji mould Aspergillus niger | 200 |
| Penicillium notatum Penicillium mineoluteum | 1000 |
| Tomato early blight bacterium Alternaria solani | 200 |
| Proteus vulgaris Proteus vulgaris | 100 |
| Candida albicans Candida albicans | 50 |
| Saccharomycete Saccharomyces cerevisiae | 50 |
S.A.Johnson has studied PCMX to the instantaneous bacterium of hand and residual neurological susceptibility, and with the triclosan contrast, testing its MIC (minimal inhibitory concentration) is 12.5-200mg/L, MBC (minimum is killed concentration) is 100-400mg/L.
Beneficial effect
(1) thimerosal of the present invention can effectively be killed 99.999% pathogenic entero becteria, pyococcus, pathogenic saccharomycete; Cut off the route of transmission of infectious disease, effectively prevention and control disease are propagated and are spread, protection people's health; Holding time is long;
(2) preparation method of thimerosal of the present invention is simple, and cost is low, is suitable for suitability for industrialized production.
Embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Embodiment 1
The thimerosal prescription
The percentage by weight of parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is 5.0: 9.5: 3.7: 25.0: 3.0: surplus.
According to above-mentioned prescription, the preparation method of thimerosal comprises:
(1) 1/3 and potassium hydroxide of deionized water in the adding prescription, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, the limit edged stirs, feed intake and finish back continuation stirring 60-70 minute, make the cocinic acid potash soap, leave standstill 6-8 hour sample examination, defective allotment is to qualified (qualified standard working substance content 〉=30%, free alkali content≤0.03%);
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving, 1/3 and above-mentioned cocinic acid potash soap of the deionized water in the adding prescription stir again; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add the residue deionized water and continue to stir, promptly.Standard total solid substance 〉=7.5% that semi-finished product are qualified, pH≤10.
PH value 9.30.
The effect that is used for textile disinfecting: under 20 ℃ ± 1 ℃ condition, the 48ml thimerosal adds 2.5L water, and the fabric soaking disinfection can effectively be killed 99.999% staphylococcus aureus in 3 minutes.
Embodiment 2
The thimerosal prescription
The percentage by weight of parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is (confirming), 7.0: 6.5: 5.4: 18.0: 4.0: surplus.
According to above-mentioned prescription, the preparation method of thimerosal comprises:
(1) 1/2 and potassium hydroxide of deionized water in the adding prescription, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, the limit edged stirs, feed intake and finish back continuation stirring 60-70 minute, make the cocinic acid potash soap, leave standstill 6-8 hour sample examination, defective allotment is to qualified (qualified standard working substance content 〉=30%, free alkali content≤0.03%);
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving, 1/3 and above-mentioned cocinic acid potash soap of deionized water in the adding prescription stir again; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add the residue deionized water and continue to stir, promptly.Standard total solid substance 〉=7.5% that semi-finished product are qualified, pH≤10.
PH value 9.38.
The effect that is used for the sterilization of floor, household surface: under 22 ℃ ± 1 ℃ condition, the 60ml thimerosal adds 1.25L water, be coated with wash the floor, household surface sterilization 3 minutes, can effectively kill 99.9% natural bacteria.
Embodiment 3
The thimerosal prescription
The percentage by weight of parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is (confirming), 6.5: 8.0: 4.5: 20.0: 4.0: surplus.
According to above-mentioned prescription, the preparation method of thimerosal comprises:
(1) 1/2 and potassium hydroxide of deionized water in the adding prescription, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, the limit edged stirs, feed intake and finish back continuation stirring 60-70 minute, make the cocinic acid potash soap, leave standstill 6-8 hour sample examination, defective allotment is to qualified (qualified standard working substance content 〉=30%, free alkali content≤0.03%);
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving, 1/3 and above-mentioned cocinic acid potash soap of deionized water in the adding prescription stir again; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add the residue deionized water and continue to stir, promptly.Standard total solid substance 〉=7.5% that semi-finished product are qualified, pH≤10.
PH value 9.35.
The effect in lavatory is used to sterilize: under 20 ℃ ± 1 ℃ condition, smear or wiping 5 minutes with thimerosal, can effectively kill 99.9% staphylococcus aureus, Escherichia coli, Candida albicans.
The raw material that uses among table 2 the foregoing description 1-3
| The source commodity title | Material content | The raw material rank |
| Parachlorometaxylenol | ≥99.0％ | Pharmaceutical grade |
| Cocinic acid | ≥99.0％ | Industry refining level |
| Potassium hydroxide | ≥48.0％ | The industry Grade A |
| Isopropyl alcohol | ≥99.0％ | Technical grade |
| Pine tar | ≥50.0％ | Technical grade |
| Deionized water |
Claims (5)
1. thimerosal prescription is characterized in that: this thimerosal prescription is, parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water, its percentage by weight be,
5.0-7.0: 6.5-9.5: 3.7-5.4: 15.0-25.0: 3.0-6.0: surplus.
2. a kind of thimerosal prescription according to claim 1 is characterized in that: the pH value of the mixed liquor that described thimerosal prescription is formed is in the alkalescent scope.
3. a kind of thimerosal prescription according to claim 1 and 2, it is characterized in that: the component of described thimerosal prescription is, parachlorometaxylenol, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water, its percentage by weight is 6.0-6.5: 7.0-9.0: 4.0-5.0: 18.0-20.0: 4.0-5.0: surplus.
4. the preparation method of a thimerosal comprises:
(1) adds deionized water and potassium hydroxide, stir, be warming up to 90 ℃-100 ℃, add cocinic acid again, make the cocinic acid potash soap;
(2) parachlorometaxylenol is mixed with isopropyl alcohol, rising temperature for dissolving adds deionized water and above-mentioned cocinic acid potash soap again, stirs; Be cooled to 30 ℃-35 ℃, add pine tar, stir, add deionized water and continue to stir, promptly;
The percentage by weight of the parachlorometaxylenol in wherein above-mentioned, cocinic acid, potassium hydroxide, isopropyl alcohol, pine tar and deionized water is, 5.0-7.0: 6.5-9.5: 3.7-5.4: 15.0-25.0: 3.0-6.0: surplus, described deionized water are the total amount in above-mentioned two steps.
5. the preparation method of a kind of thimerosal according to claim 4 is characterized in that: the cocinic acid limit edged in the described step (1) stirs, and feeds intake to finish the back and continue to stir 60-70 minute.
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| CN2011101076733A CN102293199A (en) | 2011-04-27 | 2011-04-27 | Disinfectant and preparation method thereof |
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| CN2011101076733A CN102293199A (en) | 2011-04-27 | 2011-04-27 | Disinfectant and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656717A (en) * | 2013-12-24 | 2014-03-26 | 北京绿伞化学股份有限公司 | Plant-extract-based footgear deodorant and preparation method thereof |
| CN105475280A (en) * | 2015-11-30 | 2016-04-13 | 广州世航生物科技有限公司 | Daily chemical product degerming agent and daily chemical product |
| CN107027827A (en) * | 2017-05-31 | 2017-08-11 | 太仓优活生物技术有限公司 | Preserving moisture and protecting skin disinfectant |
| CN107183058A (en) * | 2017-06-08 | 2017-09-22 | 太仓优活生物技术有限公司 | A kind of sterilized articles therefrom with good environmental protection |
| CN108617646A (en) * | 2018-06-01 | 2018-10-09 | 江苏敖广日化集团股份有限公司 | A kind of highly enriched PCMX thimerosals and preparation method thereof |
| CN109247343A (en) * | 2018-11-20 | 2019-01-22 | 娇时日化（杭州）股份有限公司 | A kind of thimerosal and preparation method thereof containing tea tree ethereal oil |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101731213A (en) * | 2009-12-18 | 2010-06-16 | 江苏省河浪生物科技有限公司 | Production process of disinfection mould-proof liquid |
| CN101916359A (en) * | 2005-01-27 | 2010-12-15 | 剑桥研究和仪器设备股份有限公司 | Methods and apparatus for classifying different parts of a sample into respective classes |
| CN101926369A (en) * | 2009-06-19 | 2010-12-29 | 王慧娟 | Disinfectant solution |
-
2011
- 2011-04-27 CN CN2011101076733A patent/CN102293199A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101916359A (en) * | 2005-01-27 | 2010-12-15 | 剑桥研究和仪器设备股份有限公司 | Methods and apparatus for classifying different parts of a sample into respective classes |
| CN101926369A (en) * | 2009-06-19 | 2010-12-29 | 王慧娟 | Disinfectant solution |
| CN101731213A (en) * | 2009-12-18 | 2010-06-16 | 江苏省河浪生物科技有限公司 | Production process of disinfection mould-proof liquid |
Non-Patent Citations (2)
| Title |
|---|
| 张文福等: "滴露消毒液的杀菌效果与抑菌能力研究", 《CHINESE JOURNAL OF DISINFECTION》, vol. 19, no. 1, 31 December 2002 (2002-12-31), pages 16 - 20 * |
| 雷德荣: "JB 新型家用消毒液的研制", 《江西化工》, no. 4, 31 December 2003 (2003-12-31), pages 125 - 127 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656717A (en) * | 2013-12-24 | 2014-03-26 | 北京绿伞化学股份有限公司 | Plant-extract-based footgear deodorant and preparation method thereof |
| CN103656717B (en) * | 2013-12-24 | 2016-05-04 | 北京绿伞化学股份有限公司 | A kind of is main Footgear deodorizer and preparation method thereof based on plant extraction liquid |
| CN105475280A (en) * | 2015-11-30 | 2016-04-13 | 广州世航生物科技有限公司 | Daily chemical product degerming agent and daily chemical product |
| CN107027827A (en) * | 2017-05-31 | 2017-08-11 | 太仓优活生物技术有限公司 | Preserving moisture and protecting skin disinfectant |
| CN107183058A (en) * | 2017-06-08 | 2017-09-22 | 太仓优活生物技术有限公司 | A kind of sterilized articles therefrom with good environmental protection |
| CN108617646A (en) * | 2018-06-01 | 2018-10-09 | 江苏敖广日化集团股份有限公司 | A kind of highly enriched PCMX thimerosals and preparation method thereof |
| CN109247343A (en) * | 2018-11-20 | 2019-01-22 | 娇时日化（杭州）股份有限公司 | A kind of thimerosal and preparation method thereof containing tea tree ethereal oil |
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Application publication date: 20111228 |