JP6984089B2 - Deodorant / disinfectant - Google Patents

Description

The present invention relates to an aqueous deodorant / disinfectant in which persimmon tannin, which is a deodorant component, and a quaternary ammonium salt, which is a cationic antibacterial agent, are simultaneously blended.

Persimmon tannin is a component contained in persimmon astringent, and persimmon astringent is a liquid made by fermenting the juice of astringent persimmon. Kakishibu has antiseptic, insect repellent and waterproof effects, and has been used for various purposes in Japan since the Heian period. Typical uses include bases and paints for wood construction, paints for Japanese umbrellas and fishing nets, and dyes for clothes (Non-Patent Document 1). Recently, it has been in the limelight again as a natural material, and new applications are being developed. For example, it is used for natural wall paint that does not cause sick building syndrome, rust preventive, and gold recovery from mobile phones. Furthermore, it has been reported that it is effective in inactivating various viruses such as norovirus, and it is attracting attention (Non-Patent Document 1). The component of persimmon astringent that has various effects in this way is persimmon tannin, which is a constituent requirement of the present invention.

Persimmon tannin is a kind of tannin, and tannin is also contained in tea, wine, etc., and is divided into water-soluble tannin (pyrogallol tannin) and condensed type tannin (catechol tannin) according to its properties. Persimmon tannin is a kind of condensed tannin (catechol tannin), but it has a large number of phenolic hydroxyl groups compared to tannins of other plants, retains extremely strong hydrogen bonding ability, and has a large molecular weight. Although there are various theories, its average molecular weight is estimated to be 13,800 (Non-Patent Document 2). In this way, persimmon tannins have a structure and properties that set them apart from the tannins of other plants. As a method for measuring the condensed tannin content contained in persimmon, the vanillin hydrochloride method is known (Non-Patent Document 3).

Further, persimmon tannin is known to have a deodorizing effect (Patent Documents 1 and 2), and a deodorizing effect on bad breath has also been confirmed (Patent Document 3 and Non-Patent Document 4). Although body odor deodorizing technology using persimmon tannin (Patent Document 4) and toilet odor deodorizing technology (Patent Document 5) are known, an aqueous solution containing a quaternary ammonium salt which is a cationic antibacterial agent at the same time. The technology for deodorizing and disinfecting agents was not known.

On the other hand, quaternary ammonium salts are used as disinfectants, surfactants, softeners, antistatic agents such as shampoos, and the like. Its antibacterial effect is high, and it is a component that is often used in pharmaceuticals and quasi-drugs.

Of these, the efficacy of benzalkonium chloride is disinfection (Non-Patent Document 5). It is a general disinfectant for disinfecting hands and fingers, and is used for disinfecting wounds on skin and mucous membranes and disinfecting infectious skin. Benzalkonium chloride is used as an active ingredient in a general inverted soap solution. It has a bactericidal effect against fungi, gram-positive bacteria, and gram-negative bacteria. The mechanism of action of benzalkonium chloride is to denature proteins on the cell membrane surface of bacteria to lose their activity, and this action functions as a bactericidal and disinfecting effect. In recent years, a technique for blending benzalkonium chloride as a deodorant composition (Patent Document 6), a technique for blending with an acne therapeutic agent (Patent Document 7), and the like have been developed.

However, since persimmon tannin and quaternary ammonium salt are suspended or precipitated by an acid-base reaction, it is difficult to mix both components at the same time. That is, no deodorant / sterilizing agent containing both components at the same time has been known.

Japanese Unexamined Patent Publication No. 61-87562 Japanese Unexamined Patent Publication No. 2005-118230 Japanese Unexamined Patent Publication No. 2006-298827 Japanese Unexamined Patent Publication No. 2001-302483 Japanese Unexamined Patent Publication No. 2015-047296 Japanese Unexamined Patent Publication No. 2015-199712 Japanese Unexamined Patent Publication No. 2007-308430

医薬品インタビューフォーム オロナイン外用液１０％（２００８） Sei Shimamoto, Chemistry of Kakishibu rooted in Japanese culture, Chemistry and Education, Vol. 64, No. 7, P348-349 (2016) Tomoaki Matsuo et al., Science and Biology, Vol. 15, No. 11, P732-736 (1977) Shinichiro Yokoyama et al., Condensed tannin content measurement method in water-insoluble persimmon (persimmon) component dry powder, analysis method manual for health functional components in food (Sangiren / Food Functional Component Analysis Study Group) Manual reference Form Ver. 1 (2012)

Pharmaceutical Interview Form Oronine External Solution 10% (2008)

As mentioned above, there is no deodorant / antibacterial agent containing persimmon tannin and quaternary ammonium salt at the same time, and it has not been known. An object of the present invention is to provide an aqueous solution-based deodorant / antibacterial agent in which persimmon tannin exhibiting high deodorizing power and a quaternary ammonium salt which is a cationic antibacterial agent are simultaneously blended.

Therefore, as a result of various diligent studies to overcome the above problems, the present inventor unexpectedly performed a suspension / precipitation reaction in an aqueous solution of persimmon tannin and a quaternary ammonium salt as a chloride of an alkali metal such as sodium chloride. It was found that it can be completely suppressed by adding chlorides of alkaline earth metals such as calcium chloride and calcium chloride. That is, the present inventor added one or more selected from sodium chloride, potassium chloride, magnesium chloride and / or calcium chloride to an aqueous solution of persimmon tannin and a quaternary ammonium salt for clear deodorization. The present invention has been accomplished by succeeding in providing an antibacterial agent. The present invention is a deodorant / antibacterial agent listed in the following [1] to [8].

[1] a) contains 0.05 to 5% by mass of persimmon tannin, b) contains 0.001 to 1% by mass of a quaternary ammonium salt, and c) contains 0.01 to 10% by mass of sodium chloride. An aqueous deodorant / disinfectant containing at least one selected from the group consisting of potassium chloride, magnesium chloride or calcium chloride.
[2] b) The quaternary ammonium salt consists of benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, methylbenzethonium chloride, domiphen bromide, stearyltrimethylammonium bromide, cetyltrimethylammonium bromide or lauryltrimethylammonium bromide. The deodorant / disinfectant according to the above [1], which is one or more selected from the group.
[3] Further, d) The deodorization according to the above [1] or [2], which contains at least one selected from the group consisting of 0.1 to 10% by mass of sodium carbonate, sodium hydrogencarbonate or sodium sesquicarbonate. Disinfectant.
[4] The deodorant / sterilizing agent according to any one of the above [1] to [3], which further contains e) 0.05 to 5% by mass of cyclodextrin and / or a derivative thereof.
[5] A spray-type deodorant / sterilizing agent prepared by filling a spray container with the composition according to any one of the above [1] to [4].
[6] The deodorant / sterilizing agent according to any one of the above [1] to [5], wherein the odor to be deodorized is body odor.
[7] The deodorant / sterilizing agent according to [6] above, which is a body odor derived from feet.
[8] The deodorant / sterilizing agent according to any one of the above [1] to [7], wherein the odor-causing substance to be deodorized is isovaleric acid.

The present invention has made it possible to provide a highly useful deodorant / antibacterial agent in which persimmon tannin having a strong deodorizing power and a quaternary ammonium salt which is a cationic antibacterial agent are simultaneously blended.

The embodiment of the present invention is a water-based liquid solution, which is used by filling it in a spray container such as a trigger bottle.

The persimmon tannin used in the present invention may be extracted from the persimmon juice, but it is preferable to use a processing raw material in consideration of the presence of impurities and the like. For example, the Pancil series (Release Science Industry Co., Ltd.) can be used. The final concentration of persimmon tannin is preferably 0.05 to 5% by mass, more preferably 0.1 to 1% by mass. If the final concentration of persimmon tannin is lower than 0.05% by mass, sufficient deodorizing power cannot be exhibited, and if it is higher than 5% by mass, the viscosity increases and the function as a liquid deodorant is impaired. .. The quantification of persimmon tannin can be performed by the vanillin hydrochloride method (Non-Patent Document 3), which is a method for quantifying condensed tannin.

The quaternary ammonium salt used in the present invention is benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, methylbenzethonium chloride, domiphen bromide, bromide, which are listed in the Japanese Pharmacopoeia and the standards for raw materials for non-pharmaceutical products. It is composed of one or more selected from stearyltrimethylammonium, cetylpyridinium bromide and lauryltrimethylammonium bromide, and the addition amount thereof is 0.001 to 1% by mass, more preferably 0.01 to 0.5% by mass. It is good to do. If the amount of quaternary ammoniu salt added is less than 0.001% by mass, sufficient antibacterial activity cannot be exhibited, and if it exceeds 1% by mass, excessive bactericidal activity may be exhibited, or foaming may interfere with use. Also, it is not preferable in terms of safety.

One or more of c) selected from sodium chloride, potassium chloride, magnesium chloride and calcium chloride, which is one of the essential constituents of the present invention, shall be one that conforms to, for example, the Japanese Pharmacopoeia or the standards for raw materials for non-pharmaceutical products. The amount added is preferably 0.01 to 10% by mass, more preferably 0.1 to 3.5% by mass. If these concentrations are less than 0.01% by mass, the suspension / precipitation reaction in the aqueous solution of persimmon tannin and quaternary ammonium salt cannot be suppressed, and if it exceeds 10% by mass, this deodorization / deodorization cannot be performed. It is not preferable in terms of the possibility that crystals are precipitated after being sprayed with the fungal agent and dried to cause a rough feeling, and that the corrosion of metals that have come into contact with the deodorant / disinfectant may be promoted.

The deodorant / disinfectant of the present invention includes d) sodium carbonate, sodium hydrogencarbonate and sodium sesquicarbonate from the viewpoint of improving the deodorizing power of short-chain fatty acid compounds such as isovaleric acid and acetic acid, which are the causative components of foot odor. It is preferable to contain one or more selected from the above. As these carbonates, for example, those conforming to the specifications for raw materials for non-medicinal products can be used (sodium sesquicarbonate is listed as trisodium dicarbonate-hydrogen hydrogen), and the amount added thereof is from the viewpoint of deodorizing power and storage stability. 0.1 to 10% by mass, more preferably 0.5 to 5% by mass.

Further, the deodorant / sterilizing agent of the present invention preferably contains e) cyclodextrin and / or a derivative thereof from the viewpoint of improving deodorizing power. In the present invention, any α-type, β-type or γ-type cyclodextrin can be used, but β-cyclodextrin is preferable from the viewpoint of cost. Further, considering the solubility in water, it is preferable to select a derivative of cyclodextrin, for example, methyl-α-cyclodextrin, ethyl-α-cyclodextrin, hydroxypropyl-α-cyclodextrin, dialkylaminoethyl-. α-cyclodextrin, sulfoalkyl-α-cyclodextrin, glycosyl-α-cyclodextrin, mannosyl-α-cyclodextrin, galactosyl-α-cyclodextrin, carboxymethyl-α-cyclodextrin, methyl-β-cyclodextrin, ethyl -Β-cyclodextrin, hydroxypropyl-β-cyclodextrin, dialkylaminoethyl-β-cyclodextrin, sulfoalkyl-β-cyclodextrin, glycosyl-β-cyclodextrin, mannosyl-β-cyclodextrin, galactosyl-β-cyclo Dextrin, carboxymethyl-β-cyclodextrin, methyl-γ-cyclodextrin, ethyl-γ-cyclodextrin, hydroxypropyl-γ-cyclodextrin, dialkylaminoethyl-γ-cyclodextrin, sulfoalkyl-γ-cyclodextrin, glycosyl Examples thereof include −γ-cyclodextrin, mannosyl-γ-cyclodextrin, galactosyl-γ-cyclodextrin, and carboxymethyl-γ-cyclodextrin. Of these, hydroxypropyl-β-cyclodextrin is preferably selected from the viewpoint of deodorizing power and cost. The concentration of cyclodextrin and / or a derivative thereof of the present invention is preferably 0.05 to 5% by mass, more preferably 0.1 to 2% by mass, from the viewpoint of deodorizing power and storage stability.

The deodorant / disinfectant of the present invention includes other deodorant materials such as tea tannin, an extract from the leaves of asparasas linearis, an extract from grape seeds, an extract from the bark such as Ezoyanagi, and a polyhydroxyamine compound. And / or it can also be used in combination with an amphoteric tenside agent or the like.

The present invention is particularly effective against body odor. The body odor that is the subject of the deodorization of the present invention includes not only the direct body odor but also the odor attached to clothes, socks and shoes. For example, if it is used for foot odor, the effect can be exhibited by spraying the deodorant / sterilizing agent of the present invention on socks or shoes.

The aqueous deodorant / disinfectant of the present invention is dissolved by adding, for example, persimmon tannin to water and then adding one or more selected from sodium chloride, potassium chloride, magnesium chloride and calcium chloride. Further, it may be prepared by adding and dissolving a quaternary ammonium salt, or a fourth solution in which one or more selected from a pre-prepared aqueous solution of persimmon tannin, sodium chloride, potassium chloride, magnesium chloride and calcium chloride is dissolved. An aqueous solution of grade ammonium may be added.

The manufactured aqueous deodorant / disinfectant can be used by filling it in a trigger bottle, for example, by spraying it into a mist on the source of the odor, or by soaking it in a cloth or sponge to remove the source of the odor. You may use it by wiping it.

Next, the present invention will be described in detail with reference to examples, but the present invention is not limited thereto. In addition, the preparation method of the deodorant / disinfectant is described in each Example and the comparative example, and the evaluation method of each sample, that is, the property (appearance) evaluation, the deodorant power test and the antibacterial power test will be described later. do. In addition, the compositions of each component in each deodorant / disinfectant are summarized in Tables 1 and 2.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 5 g (corresponding to 0.25 g of persimmon tannin) and 0.9 g of sodium chloride were dissolved in an appropriate amount of purified water. 0.1 g of benzalkonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the mixture was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 10 g (corresponding to 0.5 g of persimmon tannin) and 0.5 g of potassium chloride were dissolved in an appropriate amount of purified water. 0.01 g of benzalkonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the mixture was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 40 g (corresponding to 2 g of persimmon tannin) and 2 g of magnesium chloride were dissolved in an appropriate amount of purified water. 0.1 g of benzalkonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the mixture was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 2 g (corresponding to 0.1 g of persimmon tannin) and 3 g of calcium chloride were dissolved in an appropriate amount of purified water. 0.1 g of benzalkonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the mixture was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 5 g (corresponding to 0.25 g of persimmon tannin) and 0.1 g of potassium chloride were dissolved in an appropriate amount of purified water. 0.2 g of benzethonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 1 g (corresponding to 0.05 g of persimmon tannin) and 0.01 g of sodium chloride were dissolved in an appropriate amount of purified water. A solution prepared by dissolving 0.2 g of cetylpyridinium chloride in an appropriate amount of purified water and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then filled in a high-density polyethylene trigger bottle to obtain a deodorant / disinfectant. ..

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 80 g (corresponding to 4 g of persimmon tannin) and 3.5 g of sodium chloride were dissolved in an appropriate amount of purified water. A solution prepared by dissolving 0.2 g of methylbenzethonium chloride in an appropriate amount of purified water and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then filled in a high-density polyethylene trigger bottle to obtain a deodorant / sterilizing agent. ..

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 2 g (corresponding to 0.1 g of persimmon tannin) and 0.7 g of sodium chloride were dissolved in an appropriate amount of purified water. A solution prepared by dissolving 1 g of domiphen bromide in an appropriate amount of purified water and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorant / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 5 g (corresponding to 0.25 g of persimmon tannin) and 0.02 g of sodium chloride were dissolved in an appropriate amount of purified water. A solution prepared by dissolving 0.1 g of stearyltrimethylammonium bromide in an appropriate amount of purified water and an appropriate amount of purified water are added thereto to make the total amount 100 g, and then filled in a high-density polyethylene trigger bottle to add a deodorant / sterilizing agent. Obtained.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 10 g (corresponding to 0.5 g of persimmon tannin) and 3.5 g of sodium chloride were dissolved in an appropriate amount of purified water. 0.1 g of cetyltrimethylammonium bromide solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the mixture was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 40 g (corresponding to 2 g of persimmon tannin) and 5 g of sodium chloride were dissolved in an appropriate amount of purified water. A solution prepared by dissolving 0.1 g of lauryltrimethylammonium bromide in an appropriate amount of purified water and an appropriate amount of purified water are added thereto to make the total amount 100 g, and then filled in a high-density polyethylene trigger bottle to add a deodorant / sterilizing agent. Obtained.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 5 g (corresponding to 0.25 g of persimmon tannin), 0.9 g of sodium chloride and 3 g of sodium hydrogen carbonate were dissolved in an appropriate amount of purified water. 0.1 g of benzalkonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the mixture was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 5 g (corresponding to 0.25 g of persimmon tannin), 0.9 g of sodium chloride, 2 g of hydroxypropyl-β-cyclodextrin and 3 g of sodium hydrogen carbonate were dissolved in an appropriate amount of purified water. 0.1 g of benzalkonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the mixture was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 5 g (corresponding to 0.25 g of persimmon tannin), 0.9 g of sodium chloride, 1 g of β-cyclodextrin and 1 g of sodium carbonate were dissolved in an appropriate amount of purified water. 0.1 g of benzalkonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the mixture was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 5 g (corresponding to 0.25 g of persimmon tannin), 0.9 g of sodium chloride, 1 g of hydroxypropyl-β-cyclodextrin and 2 g of sodium sesquicarbonate were dissolved in an appropriate amount of purified water. 0.1 g of benzalkonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the mixture was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 3 g (corresponding to 0.15 g of persimmon tannin), 0.5 g of calcium chloride and 3 g of sodium hydrogen carbonate were dissolved in an appropriate amount of purified water. 0.2 g of benzethonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 3 g (corresponding to 0.15 g as persimmon tannin), calcium chloride 0.5 g, hydroxypropyl-β-cyclodextrin 2 g and sodium hydrogen carbonate 3 g were dissolved in an appropriate amount of purified water. 0.2 g of benzethonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 3 g (corresponding to 0.15 g of persimmon tannin), 0.5 g of calcium chloride, 1 g of β-cyclodextrin and 1 g of sodium carbonate were dissolved in an appropriate amount of purified water. 0.2 g of benzethonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) 3 g (corresponding to 0.15 g as persimmon tannin), calcium chloride 0.5 g, hydroxypropyl-β-cyclodextrin 1 g and sodium sesquicarbonate 2 g were dissolved in an appropriate amount of purified water. 0.2 g of benzethonium chloride solution (10%) and an appropriate amount of purified water were added thereto to make the total amount 100 g, and then the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorizing / sterilizing agent.

[Comparative Example 1]
Take 5 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (corresponding to 0.25 g of persimmon tannin) and operate in the same manner as in Example 1 except that sodium chloride is not added. It was filled to obtain a deodorant / disinfectant.

[Comparative Example 2]
Take 10 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (equivalent to 0.5 g of persimmon tannin) and operate in the same manner as in Example 2 except that potassium chloride is not added. It was filled to obtain a deodorant / disinfectant.

[Comparative Example 3]
Take 40 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (equivalent to 2 g of persimmon tannin), and operate in the same manner as in Example 3 except that magnesium chloride is not added below, and fill the trigger bottle made of high-density polyethylene. Deodorant / disinfectant was obtained.

[Comparative Example 4]
Take 2 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (corresponding to 0.1 g of persimmon tannin) and operate in the same manner as in Example 4 except that calcium chloride is not added. It was filled to obtain a deodorant / disinfectant.

[Comparative Example 5]
Take 5 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (corresponding to 0.25 g of persimmon tannin), and operate in the same manner as in Example 5 except that potassium chloride is not added. It was filled to obtain a deodorant / disinfectant.

[Comparative Example 6]
Take 1 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (corresponding to 0.05 g of persimmon tannin) and operate in the same manner as in Example 6 except that sodium chloride is not added. It was filled to obtain a deodorant / disinfectant.

[Comparative Example 7]
Take 80 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (equivalent to 4 g of persimmon tannin), and operate in the same manner as in Example 7 except that sodium chloride is not added below, and fill the trigger bottle made of high-density polyethylene. Deodorant / disinfectant was obtained.

[Comparative Example 8]
Take 2 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (corresponding to 0.1 g of persimmon tannin) and operate in the same manner as in Example 8 except that sodium chloride is not added. It was filled to obtain a deodorant / disinfectant.

[Comparative Example 9]
Take 5 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (corresponding to 0.25 g of persimmon tannin), and operate in the same manner as in Example 9 except that sodium chloride is not added. It was filled to obtain a deodorant / disinfectant.

[Comparative Example 10]
Take 10 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (equivalent to 0.5 g of persimmon tannin) and operate in the same manner as in Example 10 except that sodium chloride is not added. It was filled to obtain a deodorant / disinfectant.

[Comparative Example 11]
Take 40 g of Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) (equivalent to 2 g of persimmon tannin), and operate in the same manner as in Example 11 except that sodium chloride is not added below, and fill the trigger bottle made of high-density polyethylene. Obtained a deodorizing and disinfecting agent.

[Comparative Example 12]
The operation was the same as in Example 1 except that Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) was not added, and a high-density polyethylene trigger bottle was filled to obtain a deodorant / sterilizing agent.

[Comparative Example 13]
The operation was the same as in Example 2 except that Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) was not added, and a high-density polyethylene trigger bottle was filled to obtain a deodorant / sterilizing agent.

[Comparative Example 14]
The operation was the same as in Example 3 except that Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) was not added, and a high-density polyethylene trigger bottle was filled to obtain a deodorant / sterilizing agent.

[Comparative Example 15]
The operation was the same as in Example 4 except that Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) was not added, and a high-density polyethylene trigger bottle was filled to obtain a deodorant / sterilizing agent.

[Comparative Example 16]
The operation was the same as in Example 5 except that Pancil COS-17 (Release Kagaku Kogyo Co., Ltd.) was not added, and the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorant / sterilizing agent.

[Comparative Example 17]
The operation was the same as in Example 1 except that the benzalkonium chloride solution (10%) was not added, and the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorant / sterilizing agent.

[Comparative Example 18]
The operation was the same as in Example 2 except that the benzalkonium chloride solution (10%) was not added, and the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorant / sterilizing agent.

[Comparative Example 19]
The operation was the same as in Example 3 except that the benzalkonium chloride solution (10%) was not added, and the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorant / sterilizing agent.

[Comparative Example 20]
The operation was the same as in Example 4 except that the benzalkonium chloride solution (10%) was not added, and the bottle was filled in a high-density polyethylene trigger bottle to obtain a deodorant / sterilizing agent.

[Comparative Example 21]
The operation was the same as in Example 5 except that the benzethonium chloride solution (10%) was not added, and the bottle was filled with a high-density polyethylene trigger bottle to obtain a deodorant / sterilizing agent.

[Comparative Example 22]
Deodorant / antibacterial agent commercially available product A (lot number 634424B00405, purchased at a convenience store in Hasuda City, Saitama Prefecture in March 2017, display component: corn-derived deodorant component, sterilization component (organic))

[Comparative Example 23]
Deodorant / antibacterial agent commercially available product B (lot number WO243376, purchased at a convenience store in Hasuda City, Saitama Prefecture in March 2017, labeled ingredients: amphoteric surfactant, green tea extract, disinfectant, fragrance, ethanol )

[Comparative Example 24]
Deodorant / antibacterial agent commercially available product C (lot number GEFJ, purchased at Amazon.com in August 2017, display component: amphoteric surfactant deodorant, disinfectant, ethanol)

Table 1 is a table showing the compositions of Examples 1 to 11 and Comparative Examples 1 to 21.

Table 2 is a table showing the compositions of Examples 12 to 19.

[Test Example 1] Evaluation of properties (appearance) The properties (appearance) of Examples 1 to 19 and Comparative Examples 1 to 11 were observed, and a dissolution determination was carried out. In addition, in the dissolution judgment, − and ± were regarded as conforming, and +, ++ and +++ were regarded as unsuitable according to the following evaluation criteria. Inappropriate determination cannot maintain uniformity of content and cannot function as an aqueous deodorant / antibacterial agent. The test results are shown in Table 3.
-Dissolution criteria-: No precipitation, suspension or suspended matter is observed (conformity).
±: Very little precipitation, suspension or suspension is observed (conformity).
+: Precipitation, suspension or suspension is observed (inappropriate).
++: Many precipitates, suspensions or suspended matter are observed (inappropriate).
+++: Very many precipitates, suspensions or suspended matter (inappropriate)

Table 3 is a table showing the dissolution determination results of Examples 1 to 19 and Comparative Examples 1 to 11.

In the aqueous solution containing persimmon tannin and the quaternary ammonium salt, in Comparative Examples 1 to 11, precipitation, suspension or suspended matter was generated and the dissolution determination was unsuitable, whereas sodium chloride and chloride were found therein. Examples 1 to 19 of the present invention to which potassium, magnesium chloride or calcium chloride was added showed good solubility with no precipitation, suspension or suspension. It has been confirmed that the present invention can provide a clear deodorant / sterilizing agent containing persimmon tannin and a quaternary ammonium salt.

[Test Example 2] Deodorant power test The deodorant / sterilizing agents of Examples 1 to 5, 12 to 19 and Comparative Examples 12 to 16 and 22 to 24 were tested. Separateable flask (cylindrical type, diameter φ120 mm, body diameter φ130 mm, height 300 mm) with separable cover (flat mating type, two mouths, brim inner diameter φ120 mm, brim outer diameter 150 mm) under room temperature 23 ° C environment , Height 122 mm) was placed, and isovaleric acid gas (hereinafter abbreviated as IVA gas) was generated and filled in the flask so as to be about 20 ppm. Acetic acid detector tube No. After measuring the above-mentioned IVA gas concentration using 81 (Gastec Co., Ltd.), 5 mL of a sample (deodorant / sterilizing agent of Examples and Comparative Examples) was injected from the upper port and allowed to stand. After allowing to stand for 1 hour, the acetic acid detector tube No. The IVA gas concentration was measured using 81, and the deodorizing rate of the IVA gas was determined by the following formula.
Deodorization rate of IVA gas (%) = 100- {(IVA gas concentration after standing for 1 hour) / (IVA gas concentration before sample injection) x 100}
The test results are shown in Table 4.

Table 4 is a table showing the deodorizing power test results of Examples 1 to 5, 12 to 19 and Comparative Examples 12 to 16 and 22 to 24.

As is clear from Table 4, the deodorant rates of Comparative Examples 12 to 16 containing no persimmon tannin are less than 15%, and the deodorant rates of the deodorant / antibacterial agents commercially available products A, B and C are. While it was less than 40%, the deodorizing rates of Examples 1 to 5 and 12 to 19 of the present invention were 70% or more, showing good deodorizing power. Further, among the examples of the present invention, a sample to which sodium carbonate, sodium hydrogencarbonate or sodium sesquicarbonate was added (Examples 12 and 16), and a sample to which hydroxypropyl-β-cyclodextrin or β-cyclodextrin was further added. The IVA gas deodorization rate of (Examples 13 to 15 and 17 to 19) was particularly high and good.

[Test Example 3] (Antibacterial activity test)
Tests were carried out on the deodorant / sterilizing agents of Examples 1 to 5, 12 to 19 and Comparative Examples 17 to 24. Various germs in the skin stratum corneum were collected from the soles of healthy male feet by the tape stripping method (cellophane tape; 15 mm x 70 mm was used to peel off the skin stratum corneum around the soles of the toes). 25 mL of physiological saline was added to the cellophane tape to which the stratum corneum was attached and shaken to extract germs and uniformly disperse them (miscellaneous germ extraction stock solution). The undiluted solution for extracting various germs was diluted 10-fold with physiological saline to obtain a sterilized extract diluted solution. Add 0.5 mL of the deodorant / sterilizing agent of each example or comparative example to 1 mL of the miscellaneous bacteria extraction diluted solution, shake the mixture, allow to stand for 30 minutes, and put these solutions in a standard agar plate medium. In addition to (diameter 10 cm, depth 1.5 cm), the mixture was well mixed and cultured at 35 ± 1.0 ° C. for 48 ± 3 hours to count the number of bacterial colonies. In addition, the control was operated in the same manner by adding 0.5 mL of purified water to 1 mL of the diluted solution for extracting germs instead of 0.5 mL of the deodorant / disinfectant. In addition, both the undiluted solution for extracting germs and the diluted solution for extracting germs were prepared at the time of use. The antibacterial activity was judged to be suitable for − and ± and unsuitable for + and ++ according to the following bacterial growth evaluation criteria. Since the sample judged to be unsuitable does not have sufficient antibacterial activity, it cannot function as a deodorant / antibacterial agent.
-: No bacterial growth was observed (no bacterial colony was observed in the Petri dish) (conformity)
±: Bacterial growth was significantly suppressed compared to the control (the number of bacterial colonies in the Petri dish was significantly lower than that of the control) (fit)
+: Similar growth of bacteria was observed compared to the control (the number of bacterial colonies in the Petri dish was the same as that of the control) (inappropriate).
The test results are shown in Table 5.

Table 5 is a table showing the antibacterial activity test results of Examples 1 to 5, 12 to 19 and Comparative Examples 17 to 24.

As is clear from Table 5, Comparative Examples 17 to 21 containing no quaternary ammonium salt showed the same level of bacterial growth as the control, and the determination of antibacterial activity was inappropriate. In addition, the deodorant / antibacterial agents commercially available products A and B completely inhibited the growth of bacteria, and the products C sold by other companies showed the same degree of bacterial growth as the control, and the determination of antibacterial activity was inappropriate. On the other hand, the effect of suppressing the growth of the bacteria of Examples 1 to 5 and 12 to 19 of the present invention was remarkable, and it was confirmed that the antibacterial activity was suitable.

INDUSTRIAL APPLICABILITY According to the present invention, it is useful to simultaneously combine persimmon tannin having a strong deodorizing power, which was conventionally impossible to mix in an aqueous deodorant / disinfectant, and a quaternary ammonium salt having high versatility as an antibacterial agent. It has made it possible to provide highly deodorant and antibacterial agents.

Claims (8)

a) 0.05 to 5% by mass of persimmon tannin, b) 0.001 to 1% by mass of quaternary ammonium salt, and c) 0.01 to 10% by mass of sodium chloride and potassium chloride. An aqueous deodorant / disinfectant containing at least one selected from the group consisting of magnesium chloride or calcium chloride. b) The quaternary ammonium salt is selected from the group consisting of benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, methylbenzethonium chloride, domiphen bromide, stearyltrimethylammonium bromide, cetyltrimethylammonium bromide or lauryltrimethylammonium bromide. The deodorant / disinfectant according to claim 1, which is one or more of them. Further, d) The deodorant / disinfectant according to claim 1 or 2, which contains at least one selected from the group consisting of 0.1 to 10% by mass of sodium carbonate, sodium hydrogencarbonate or sodium sesquicarbonate. Further, the deodorant / sterilizing agent according to any one of claims 1 to 3, which further contains e) 0.05 to 5% by mass of cyclodextrin and / or a derivative thereof. A spray-type deodorant / sterilizing agent obtained by filling a spray container with the composition according to any one of claims 1 to 4. The deodorant / sterilizing agent according to any one of claims 1 to 5, wherein the odor to be deodorized is body odor. The deodorant / sterilizing agent according to claim 6, which is a body odor derived from feet. The deodorant / sterilizing agent according to any one of claims 1 to 7, wherein the odor-causing substance to be deodorized is isovaleric acid.