CN106389466A - 98-compound iodine disinfection solution and preparation method thereof - Google Patents
98-compound iodine disinfection solution and preparation method thereof Download PDFInfo
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- CN106389466A CN106389466A CN201611029856.7A CN201611029856A CN106389466A CN 106389466 A CN106389466 A CN 106389466A CN 201611029856 A CN201611029856 A CN 201611029856A CN 106389466 A CN106389466 A CN 106389466A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses a 98-compound iodine disinfection solution. Each 100ml of the disinfection solution contains the components such as effective iodine, chlorhexidine, alkylphenol polyoxyethylene ether, a defoaming agent, chlorhexidine, glycerin, an antibacterial synergist and purified water. The invention further discloses a preparation method of the 98-compound iodine disinfection solution. The 98-compound iodine disinfection solution prepared by virtue of the preparation method is capable of rapidly and efficiently killing common germs such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and Candida albicans in hospitals, and the sterilizing rate can be infinitely close to 100%, so that the 98-compound iodine disinfection solution can be widely applied to the clinical medicine.
Description
Technical field
The present invention relates to Medical antiseptic solution field, particularly to a kind of 98 compound iodic disinfecting liquids and preparation method thereof.
Background technology
Iodic disinfecting liquid is to be the disinfectant solution that main sterilization component is made with iodine, and it is so that protein is sunk by free I
The class that bactericidal action is played in shallow lake is efficient, broad-spectrum disinfectant, can quickly kill the diseases such as antibacterial, spore, virus, phage, funguses
Substance.Common sterile products have ethanol, povidone iodine, hibitane iodine composite disinfecting product.Wherein, hibitane iodine composite disinfecting produces
Product, are to be mixed with hibitane by iodine to form, and its bactericidal effect is more powerful compared with hibitane or iodine, has broad-spectrum sterilization well
Effect.
Sterilization to human body skin, often using sterilized cotton ball or cotton swab, disinfecting process is generally divided into two steps to be carried out：
First, carry out scrape skin using the absorbent cotton containing iodine tincture and reach the purpose killing antibacterial；Second, for the disinfectant solution that disappears to skin
Zest, carries out second wiping using alcoholic absorbent cotton, dilutes the iodine tincture content on skin by ethanol.Above-mentioned carry out
Sterilization twice relatively complicated, increased the workload of medical and nursing work personnel, and within the busy working time, some medical cares
Personnel easily forget to carry out second step, consequently, it is possible to not only reduce Disinfection Effect, also can increase the misery of patient；Have
A little medical personnel may carelessness carry out disinfection within the busy working time, causes to operate incorrect.If in second step mistake
Operate incorrect in journey it is possible to Disinfection Effect can be affected, or even cause cross-contamination.
Content of the invention
The technical problem to be solved in the present invention is to provide a kind of collocation method unique, and configuration disinfectant solution sterilizing rate out is high
98 compound iodic disinfecting liquids and preparation method thereof.
In order to solve above-mentioned technical problem, the technical scheme is that：A kind of 98 compound iodic disinfecting liquids, every 100ml disappears
The mass component containing in venom is：1～1.6 part of available iodine, 0.1～0.3 part of hibitane, alkylphenol polyoxyethylene 0.2～
0.3 part, 0.4～0.5 part of defoamer, 0.5～0.6 part of hibitane, 1～3 part of glycerol, 2～5 parts of Trimethoprim, polyoxyethylene
3～6 parts of Oleum Ricini, remaining is purified water.
Further, the mass component containing in every 100ml disinfectant solution is：1.4 parts of available iodine, 0.15 part of hibitane,
0.2 part of alkylphenol polyoxyethylene, defoamer 0.4,0.5 part of hibitane, 1.5 parts of glycerol, 3 parts of Trimethoprim, polyoxyethylene
3.5 parts of Oleum Ricini, remaining is purified water.
Further, described hibitane is according to chlorhexidine acetate or chlorhexidine hydrochloride, the body with citric acid hibitane
Long-pending ratio is 1:1.2 ratio mixes.
Further, described Trimethoprim is trimethoprim.
The present invention also provides a kind of preparation method occuping above-mentioned disinfectant solution, comprises the following steps：
(1) carry out disinfection marking graduated dispensing containers at high temperature, dry standby in an aseptic environment；
(2) add the purified water of 60～80ml into described dispensing containers；
(3) chlorine has been successively into described dispensing containers to be combined the proportioning of iodic disinfecting liquid according to 98 described in claim 1 or 2
Calmly, alkylphenol polyoxyethylene, defoamer and hibitane, stir, and standing obtains solution A in 10～18 minutes；
(4) take aseptic graduated cylinder, and add glycerol and polyoxy second according to the ratio of claim 1 or 2 to described aseptic graduated cylinder
Alkene Oleum Ricini, obtains solution B after stirring；
(5) solution B is poured in solution A, described backward aseptic graduated cylinder in pour the purified water of 10ml into, rock half a minute
After pour into and in solution B, obtain solution C, agitating solution C is uniform；
(6) Trimethoprim, available iodine are added successively in solution C according to the ratio of claim 1 or 2；
(7) add deionized water solvent into described dispensing containers, until whole sterilization medicinal liquid reaches 100ml；
(8) stir sterilization medicinal liquid, is then charged in tank the liquid finished product that is sterilized；
Further, the maximum capacity of described dispensing containers is 120ml.
Further, described solution A, solution B and solution C all configure at room temperature and form.
Further, in described step (3), the time standing described solution A is 16 minutes.
Compared with prior art, beneficial effects of the present invention are：
The compound iodic disinfecting liquid in the 98 of the present invention can once can complete to patient skin sterilization in clinical medicine uses, and subtracts
The light labor intensity of medical personnel, it is to avoid the occurrence of by mistake sterilization, poor sense will not occur in disinfecting process simultaneously
Dye is so as in clinical medicine using more convenient.
Meanwhile, the present invention, using the collocation method of specialty, will distil under slight fever, and have volatile available iodine and be placed on
Final step adds, and can effectively prevent the volatilization of available iodine, remain the disinfection pharmacology of available iodine very well, using this preparation
The 98 compound iodic disinfecting liquids that method is prepared out can quickly, efficiently kill escherichia coli, staphylococcus aureuses, the false list of Aerugo
The common pathogenic bacteria of the hospitals such as born of the same parents bacterium, Candida albicans, and sterilizing rate can infinite approach a hundred per cent.
Specific embodiment
Below the specific embodiment of the present invention is described further.Here is it should be noted that implement for these
The explanation of mode is used to help understand the present invention, but does not constitute limitation of the invention.Additionally, invention described below
As long as involved technical characteristic does not constitute conflict each other and just can be mutually combined in each embodiment.
The invention mainly comprises two parts：One is 98 compound iodic disinfecting liquid formula, and two is using specialty for this disinfectant solution
Preparation method, below taking the disinfectant solution of 100ml as a example, with formula combine preparation method come the present invention will be described.
Embodiment 1：
The mass component that 98 compound iodic disinfecting liquids contain is：1 part of available iodine, 0.1 part of hibitane, alkylphenol polyoxyethylene
0.2 part, 0.4 part of defoamer, 0.5 part of hibitane, 1 part of glycerol, 2 parts of Trimethoprim, 3 parts of polyoxyethylene castor oil, remaining is
Purified water.Wherein, hibitane be the volume ratio according to chlorhexidine acetate or chlorhexidine hydrochloride and citric acid hibitane be 1:1.2
Ratio mixes；Trimethoprim is trimethoprim.
In actual preparation, first, maximum capacity is taken to be 120ml and mark graduated dispensing containers and disappeared at high temperature
Poison, is added thereto to the purified water of 60～80ml in temperature for 21-25 DEG C (hereinafter referred to as room temperature) after drying in an aseptic environment,
Then according to above-mentioned mass component hibitane, alkylphenol polyoxyethylene, defoamer and wash must successively into this dispensing containers
Thailand, stirs, standing obtain solution A within 15 minutes, remaining available iodine, glycerol, polyoxyethylene castor oil, Trimethoprim,
Follow-up addition.
Secondly, take aseptic graduated cylinder, add glycerol to aseptic graduated cylinder at room temperature according to above-mentioned mass component ratio and gather
Oxygen ethylene castor oil, obtain solution after stirring, solution B poured in solution A, aseptic backward graduated cylinder in pour 10ml's into
Purified water, pours into after rocking half a minute in solution B and obtains solution C, and agitating solution C is uniform.
Again, add Trimethoprim, available iodine successively in solution C according to above-mentioned mass component, backward configuration
Deionized water solvent is added, until whole sterilization medicinal liquid reaches 100ml, stir sterilization medicinal liquid, is then charged into tank in container
Inside be sterilized liquid finished product.So far, 98 compound iodic disinfecting liquids are just prepared and are completed.
Embodiment 1 sterilization conditions table：
Embodiment 2：
The mass component that 98 compound iodic disinfecting liquids contain is：1.6 parts of available iodine, 0.3 part of hibitane, alkylphenol-polyethenoxy
0.3 part of ether, 0.5 part of defoamer, 0.6 part of hibitane, 3 parts of glycerol, 5 parts of Trimethoprim, 6 parts of polyoxyethylene castor oil, remaining
For purified water.Wherein, hibitane be the volume ratio according to chlorhexidine acetate or chlorhexidine hydrochloride and citric acid hibitane be 1:1.2
Ratio mix；Trimethoprim is trimethoprim.
In actual preparation, first, maximum capacity is taken to be 120ml and mark graduated dispensing containers and disappeared at high temperature
Poison, is added thereto to the purified water of 60～80ml in room temperature, then according to above-mentioned mass component into this dispensing containers successively
Hibitane, alkylphenol polyoxyethylene, defoamer and hibitane, stir, and standing obtains solution A in 16 minutes, and remaining have
Effect iodine, glycerol, polyoxyethylene castor oil, Trimethoprim, follow-up addition.
Secondly, take aseptic graduated cylinder, add glycerol to aseptic graduated cylinder at room temperature according to above-mentioned mass component ratio and gather
Oxygen ethylene castor oil, obtain solution after stirring, solution B poured in solution A, aseptic backward graduated cylinder in pour 10ml's into
Purified water, pours into after rocking half a minute in solution B and obtains solution C, and agitating solution C is uniform.
Again, add Trimethoprim, available iodine successively in solution C according to above-mentioned mass component, backward configuration
Deionized water solvent is added, until whole sterilization medicinal liquid reaches 100ml, stir sterilization medicinal liquid, is then charged into tank in container
Inside be sterilized liquid finished product.So far, 98 compound iodic disinfecting liquids are just prepared and are completed.
Embodiment 2 sterilization conditions table：
Embodiment 3：
The mass component that 98 compound iodic disinfecting liquids contain is：1.4 parts of available iodine, 0.15 part of hibitane, alkyl phenol polyoxy second
0.2 part of alkene ether, defoamer 0.4,0.5 part of hibitane, 1.5 parts of glycerol, 3 parts of Trimethoprim, 3.5 parts of polyoxyethylene castor oil,
Remaining is purified water.Wherein, hibitane is to be with the volume ratio of citric acid hibitane according to chlorhexidine acetate or chlorhexidine hydrochloride
1:1.2 ratio mixes；Trimethoprim is trimethoprim.
In actual preparation, collocation method is consistent with embodiment 2, is not just repeating here.
Embodiment 3 sterilization conditions table：
The 98 compound iodic disinfecting liquids that can be seen that the present invention from the form of embodiment 3 using mass component are：Available iodine
1.4 parts, 0.15 part of hibitane, 0.2 part of alkylphenol polyoxyethylene, defoamer 0.4,0.5 part of hibitane, 1.5 parts of glycerol, antibacterial
3 parts of synergist, 3.5 parts of polyoxyethylene castor oil, remaining is purified water formula, and the sterilization configuring out according to professional method
Liquid can infinite approach 100% to pathogenic bacteria highest sterilizing rate.Therefore, the present invention, using the collocation method of specialty, will be under slight fever
Distillation, there is volatile available iodine it is placed on final step to add, can effectively prevent the volatilization of available iodine, remain effectively very well
The disinfection pharmacology of iodine, can quickly, efficiently kill large intestine using the 98 compound iodic disinfecting liquids that this preparation method is prepared out
The common pathogenic bacteria of the hospitals such as bacillus, staphylococcus aureuses, Pseudomonas aeruginosa, Candida albicans, and sterilizing rate can infinite approach
Absolutely.
Meanwhile, the 98 of the present invention compound iodic disinfecting liquids can be once complete to patient skin sterilization in clinical medicine uses
Become, alleviate the labor intensity of medical personnel, it is to avoid the occurrence of by mistake sterilize, will not occur relatively in disinfecting process simultaneously
Difference infection is so as in clinical medicine using more convenient.
Above embodiments of the present invention are explained in detail, but the invention is not restricted to described embodiment.Right
For those skilled in the art, in the case of without departing from the principle of the invention and spirit, these embodiments are carried out many
Plant change, modification, replace and modification, still fall within protection scope of the present invention.
Claims (8)
1. a kind of 98 compound iodic disinfecting liquids are it is characterised in that the mass component containing in every 100ml disinfectant solution is：Available iodine 1～
1.6 parts, 0.1～0.3 part of hibitane, 0.2～0.3 part of alkylphenol polyoxyethylene, 0.4～0.5 part of defoamer, hibitane 0.5
～0.6 part, 1～3 part of glycerol, 2～5 parts of Trimethoprim, 3～6 parts of polyoxyethylene castor oil, remaining be purified water.
2. according to claim 1 98 compound iodic disinfecting liquids it is characterised in that：The quality containing in every 100ml disinfectant solution
Group is divided into：1.4 parts of available iodine, 0.15 part of hibitane, 0.2 part of alkylphenol polyoxyethylene, defoamer 0.4,0.5 part of hibitane,
1.5 parts of glycerol, 3 parts of Trimethoprim, 3.5 parts of polyoxyethylene castor oil, remaining is purified water.
3. according to claim 1 and 2 98 compound iodic disinfecting liquids it is characterised in that：Described hibitane is according to acetic acid chlorine
Oneself determines or chlorhexidine hydrochloride, and the volume ratio with citric acid hibitane is 1:1.2 ratio mixes.
4. according to claim 1 and 2 98 compound iodic disinfecting liquids it is characterised in that：Described Trimethoprim is trimethoxy
Benzyl Aminometradine.
5. a kind of 98 compound iodic disinfecting liquid preparation methoies are it is characterised in that comprise the following steps：
(1) carry out disinfection marking graduated dispensing containers at high temperature, dry standby in an aseptic environment；
(2) add the purified water of 60～80ml into described dispensing containers；
(3) according to 98 described in claim 1 or 2 be combined iodic disinfecting liquid proportioning into described dispensing containers successively hibitane,
Alkylphenol polyoxyethylene, defoamer and hibitane, stir, and standing obtains solution A in 10～18 minutes；
(4) take aseptic graduated cylinder, and add glycerol and polyoxyethylene castor according to the ratio of claim 1 or 2 to described aseptic graduated cylinder
Oleum Sesami, obtains solution B after stirring；
(5) solution B is poured in solution A, described backward aseptic graduated cylinder in pour the purified water of 10ml into, fall after rocking half a minute
Enter and in solution B, obtain solution C, agitating solution C is uniform；
(6) Trimethoprim, available iodine are added successively in solution C according to the ratio of claim 1 or 2；
(7) add deionized water solvent into described dispensing containers, until whole sterilization medicinal liquid reaches 100ml；
(8) stir sterilization medicinal liquid, is then charged in tank the liquid finished product that is sterilized；
6. according to claim 5 98 compound iodic disinfecting liquid preparation methoies are it is characterised in that the maximum of described dispensing containers
Capacity is 120ml.
7. according to claim 5 98 compound iodic disinfecting liquid preparation methoies it is characterised in that described solution A, solution B with
And solution C all configures at room temperature and forms.
8. according to claim 5 98 compound iodic disinfecting liquid preparation methoies are it is characterised in that in described step (3), stand
The time of described solution A is 16 minutes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201611029856.7A CN106389466A (en) | 2016-11-15 | 2016-11-15 | 98-compound iodine disinfection solution and preparation method thereof |
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| CN201611029856.7A CN106389466A (en) | 2016-11-15 | 2016-11-15 | 98-compound iodine disinfection solution and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107251920A (en) * | 2017-07-12 | 2017-10-17 | 合肥华盖生物科技有限公司 | It is a kind of for thimerosal of animal husbandry and preparation method thereof |
| WO2018202687A1 (en) * | 2017-05-02 | 2018-11-08 | Pierre Fabre Medicament | Antiseptic composition combining chlorhexidine and iodine |
| CN114868762A (en) * | 2022-04-23 | 2022-08-09 | 杭州西子卫生消毒药械有限公司 | Composite intermediate-effect disinfectant and preparation method thereof |
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| CN114868762A (en) * | 2022-04-23 | 2022-08-09 | 杭州西子卫生消毒药械有限公司 | Composite intermediate-effect disinfectant and preparation method thereof |
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Application publication date: 20170215 |