JP2006206535A - Washing disinfectant for medical equipment - Google Patents
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本発明は人工透析装置とそれに付随する配管、歯科用医療機器、及び内視鏡等を始めとするさまざまな医療機器用洗浄消毒剤に関し、更に詳しくは、洗浄及び消毒効果に優れ、環境負荷が少なく、安全性の高い医療機器用洗浄消毒剤に関する。 The present invention relates to an artificial dialysis apparatus and its accompanying piping, dental medical equipment, and various medical equipment cleaning and disinfecting agents such as endoscopes. More specifically, the present invention has excellent cleaning and disinfecting effects and has an environmental impact. The present invention relates to a small and highly safe cleaning and disinfectant for medical equipment.
人工透析装置とそれに付随する配管には、透析治療を行うたびに患者体内より濾過されたタンパク質等の老廃物や透析治療に使用される透析液由来の炭酸カルシウムが付着し、それを放置すると装置の誤作動や細菌の増殖による感染症、細菌から生成されるエンドトキシン等の毒素による発熱などがおこり正常な透析治療ができなくなる。そのため、透析治療を安全に行うには、人工透析装置とその周辺機器等の洗浄（除去）と消毒を適宜行うことが不可欠である。 When the dialysis treatment is performed, waste products such as proteins filtered from the patient's body and calcium carbonate derived from the dialysate used for dialysis treatment adhere to the artificial dialysis device and the piping associated therewith. Infection caused by malfunction of bacteria, bacterial infection, fever by toxins such as endotoxin produced from bacteria, etc., and normal dialysis treatment becomes impossible. Therefore, in order to safely perform dialysis treatment, it is indispensable to appropriately wash (remove) and disinfect the artificial dialysis apparatus and its peripheral devices.
人工透析装置及びその周辺機器の洗浄および消毒方法としては、患者体内より濾過されたタンパク質等の老廃物の洗浄と消毒を目的に次亜塩素酸ナトリウムを用いる方法と炭酸カルシウムの洗浄を目的に酢酸を用いる方法とを連続して行う方法、消毒と炭酸カルシウムの洗浄を目的に過酢酸水溶液を用いる方法と患者体内より濾過されたタンパク質等の老廃物の洗浄目的に次亜塩素酸ナトリウムを用いる方法を連続して行う方法（例えば、特許文献１参照）、過酢酸水溶液にリン酸等の無機酸を加えタンパク質等の洗浄能力を高めた水溶液を用い、消毒と炭酸カルシウムの洗浄と患者体内より濾過されたタンパク質等の老廃物の洗浄を一度に行う方法等がある。 Methods for cleaning and disinfecting the artificial dialysis machine and its peripheral devices include a method using sodium hypochlorite for the purpose of cleaning and disinfecting waste products such as proteins filtered from the patient's body and acetic acid for the purpose of cleaning calcium carbonate. A method of using sodium hypochlorite for the purpose of cleaning waste products such as proteins filtered from the body of a patient, a method of using a peracetic acid solution for the purpose of disinfection and cleaning of calcium carbonate (For example, see Patent Document 1), using an aqueous solution in which an inorganic acid such as phosphoric acid is added to an aqueous solution of peracetic acid to improve the washing ability of proteins, etc., disinfection, washing of calcium carbonate, and filtration from the patient For example, there is a method of cleaning waste products such as proteins at once.
また、歯科用医療機器は口腔内で使用されることが多く、体液やさまざまな汚れが付着するためその洗浄はもちろん、細菌やウイルス等による二次的感染を防止するための消毒も適宜行う必要があり、一般的には、次亜塩素酸ナトリウムや塩化ベンザルコニウムに界面活性剤を加えた水溶液等により洗浄及び消毒を行う方法等がある。 In addition, dental medical devices are often used in the oral cavity, and since body fluids and various types of dirt adhere to them, it is necessary to clean them as well as disinfect them to prevent secondary infections caused by bacteria and viruses. In general, there is a method of cleaning and disinfecting with an aqueous solution obtained by adding a surfactant to sodium hypochlorite or benzalkonium chloride.
また、内視鏡は患者体内に挿入し使用するため、体液や老廃物等、使用部位によりさまざまな汚れが付着するため、その洗浄はもちろん、細菌やウイルス等による二次的感染を防止するための消毒も適宜行う必要があり、一般的には、界面活性剤やタンパク分解酵素等で汚れを洗浄し、その後グルタールアルデヒド等の殺菌剤で消毒を行う方法等がある。 In addition, because endoscopes are inserted into the patient's body and used, various stains such as body fluids and wastes adhere to the site of use. In addition to cleaning, endoscopes are used to prevent secondary infections such as bacteria and viruses. In addition, there is a method in which dirt is washed with a surfactant or a proteolytic enzyme and then disinfected with a disinfectant such as glutaraldehyde.
また、過酸化水素３．５〜６％、有機酸５〜３０％、及び有機過酸０．４〜３．４％を含み、（有機酸＋有機過酸）／過酸化水素の重量比が１以上である水溶液からなる医療機器用消毒洗浄剤が提案されている（例えば、特許文献２参照）。
更に、過酢酸、酢酸、過酸化水素及び無機酸を含有する殺菌洗浄剤組成物が提案されている（例えば、特許文献３参照）。
Furthermore, a bactericidal cleaning composition containing peracetic acid, acetic acid, hydrogen peroxide and an inorganic acid has been proposed (see, for example, Patent Document 3).
しかしながら、次亜塩素酸ナトリウム洗浄と酢酸洗浄を連続して行う方法や、過酢酸水溶液洗浄と次亜塩素酸ナトリウム洗浄を連続して行う方法は、次亜塩素酸ナトリウムの特性である強い腐食性によって装置部品や配管等の劣化がおこるばかりでなく、２種類の洗浄方法を連続して行うことから作業上煩雑であり、多大な労力と時間を費やすという問題がある。また、実際の透析治療現場においては夜間遅い時間まで治療を行う場合もあり、２種類の洗浄方法を連続して行うことが出来ない場合もある。更に、塩素を未処理のまま廃液として排出し環境に悪影響を与えるという問題もある。 However, the method of performing sodium hypochlorite cleaning and acetic acid cleaning in succession, and the method of performing peracetic acid aqueous solution cleaning and sodium hypochlorite cleaning continuously are the strong corrosive properties that are characteristic of sodium hypochlorite. In addition to the deterioration of the device parts and piping, the two cleaning methods are continuously performed, which is cumbersome in work and requires a lot of labor and time. Further, in an actual dialysis treatment site, treatment may be performed until late at night, and two types of cleaning methods may not be performed continuously. Furthermore, there is also a problem in that chlorine is discharged as a waste liquid without being treated, thereby adversely affecting the environment.
また、過酢酸水溶液にリン酸等の無機酸を加えた水溶液を用いる洗浄方法の場合は、一般に多量のリンを使用することになるが、リンは環境負荷物質の代表的な物質であるため、この方法で洗浄を行うと自然環境に多大な影響を与えることが避けられない。 In the case of a cleaning method using an aqueous solution in which an inorganic acid such as phosphoric acid is added to an aqueous solution of peracetic acid, a large amount of phosphorus is generally used. However, since phosphorus is a representative substance of environmental impact, When cleaning is performed by this method, it is inevitable that the natural environment will be greatly affected.
また、歯科用医療機器において、従来の次亜塩素酸ナトリウムや塩化ベンザルコニウムに界面活性剤を加えた水溶液等により洗浄及び消毒を行う方法は、次亜塩素酸ナトリウムや塩化ベンザルコニウムの特性である強い腐食性によって機器の部品の劣化がおこる上、塩素を未処理のまま廃液として排出し環境を悪化させるという問題を含んでいる。
また、内視鏡において、従来のグルタールアルデヒドを使用する洗浄方法は、グルタールアルデヒド自体の毒性が強く作業者に対する安全確保に多大な注意が必要であり、かつ、タンパク質の凝固作用が強いため体液等の汚れが落としにくいという問題をはらんでいる。
Also, in dental medical devices, the conventional method of cleaning and disinfecting with sodium hypochlorite or benzalkonium chloride in an aqueous solution containing a surfactant is the characteristic of sodium hypochlorite or benzalkonium chloride. In addition to the deterioration of the parts of the equipment due to the strong corrosiveness, the problem is that chlorine is discharged as waste liquid untreated and the environment is deteriorated.
Also, in conventional endoscopes, the conventional cleaning method using glutaraldehyde is highly toxic to glutaraldehyde itself and requires great care to ensure the safety of workers, and also has a strong protein coagulation effect. There is a problem that dirt such as body fluids is difficult to remove.
更に、過酸化水素、有機酸及び有機過酸を含有する医療機器用消毒洗浄剤は、リン酸等の環境負荷物質を含まないものの、タンパク質等の老廃物や炭酸カルシウムの洗浄力が十分でないという問題を有している。 Furthermore, although disinfecting detergents for medical devices containing hydrogen peroxide, organic acids and organic peracids do not contain environmentally hazardous substances such as phosphoric acid, the cleaning power of protein and other waste products and calcium carbonate is not sufficient. Have a problem.
更にまた、過酢酸、酢酸、過酸化水素及び無機酸を含有する殺菌洗浄剤組成物は、例えば、実施例において、リン酸を２０％又は４０％含有する殺菌洗浄剤組成物が示されているが、このように多量のリン酸を使用すれば、前記した如く、環境への多大な影響は避けられない。 Furthermore, as for the germicidal detergent composition containing peracetic acid, acetic acid, hydrogen peroxide and inorganic acid, for example, the germicidal detergent composition containing 20% or 40% phosphoric acid is shown in the examples. However, if such a large amount of phosphoric acid is used, as described above, a great influence on the environment is inevitable.
本発明は、上記実情に鑑み、人工透析装置とそれに付随する配管、歯科用医療機器、及び内視鏡等を始めとするさまざまな医療機器の洗浄及び消毒において、一度の操作で効果の高い洗浄と消毒が可能で、環境負荷が少なく、取り扱いの安全性が高い洗浄消毒剤を提供することを目的としている。 In view of the above circumstances, the present invention is highly effective in a single operation for cleaning and disinfecting various medical devices including an artificial dialysis device and its associated piping, dental medical devices, and endoscopes. The purpose is to provide a cleaning disinfectant that can be disinfected, has a low environmental impact, and is highly safe to handle.
上記目的を達成するために、請求項１の発明は、過酸化水素０．１〜６．０重量％、有機過酸０．１〜２．０重量％、有機酸０．５〜４０重量％を含有してなり、前記有機酸が酢酸と、酒石酸及び／又はマロン酸とからなことを特徴とする医療機器用洗浄消毒剤を内容とする。 In order to achieve the above object, the invention of claim 1 includes hydrogen peroxide 0.1 to 6.0% by weight, organic peracid 0.1 to 2.0% by weight, organic acid 0.5 to 40% by weight. A cleaning / disinfectant for medical equipment, characterized in that the organic acid comprises acetic acid and tartaric acid and / or malonic acid.
請求項２の発明は、過酸化水素０．１〜６．０重量％、有機過酸０．１〜２．０重量％、有機酸０．５〜４０重量％、無機酸０．５〜２．０％を含有してなり、前記有機酸が酢酸と、酒石酸及び／又はマロン酸とからなことを特徴とする医療機器用洗浄消毒剤を内容とする。 The invention of claim 2 comprises hydrogen peroxide 0.1-6.0% by weight, organic peracid 0.1-2.0% by weight, organic acid 0.5-40% by weight, inorganic acid 0.5-2%. A cleaning / disinfecting agent for medical equipment, characterized in that it contains 0.0% and the organic acid comprises acetic acid and tartaric acid and / or malonic acid.
請求項３の発明は、酢酸と、酒石酸及び／又はマロン酸との割合が重量基準で前者が１に対して後者が１〜３であることを特徴とする請求項１又は２記載の医療機器用洗浄消毒剤を内容とする。 The invention according to claim 3 is characterized in that the ratio of acetic acid and tartaric acid and / or malonic acid is 1 on the basis of weight and 1 to 2 on the basis of weight. Contains cleaning disinfectant.
請求項４の発明は、無機酸がリン酸、硝酸、硫酸から選ばれる少なくとも１種であることを特徴とする請求項２又は３記載の医療機器用洗浄消毒剤を内容とする。 The invention according to claim 4 contains the cleaning / disinfecting agent for medical equipment according to claim 2 or 3, wherein the inorganic acid is at least one selected from phosphoric acid, nitric acid, and sulfuric acid.
請求項５の発明は、無機酸がリン酸であることを特徴とする請求項２〜４のいずれか１項に記載の医療機器用洗浄消毒剤を内容とする。 The invention according to claim 5 contains the cleaning / disinfecting agent for medical equipment according to any one of claims 2 to 4, wherein the inorganic acid is phosphoric acid.
請求項６の発明は、リン酸の含有量が１重量％未満であることを特徴とする請求項４又は５記載の医療機器用洗浄消毒剤を内容とする。 The invention according to claim 6 contains the cleaning / disinfecting agent for medical equipment according to claim 4 or 5, wherein the phosphoric acid content is less than 1% by weight.
本発明は、環境負荷物質であるリン酸に代表される無機酸の量を使用しないか又は環境に悪影響がない程度の量に減少させ、これの不使用又は減少によるタンパク質等に対する溶解力の低下を、有機酸として、酢酸と、酒石酸及び／又はマロン酸とを併用することによる補完したことを特徴とし、従って、洗浄消毒効果に優れるとともに、環境負荷が無いか又は少なく、安全性の高い医療機器用洗浄消毒剤を提供することができる。 In the present invention, the amount of inorganic acid typified by phosphoric acid, which is an environmental load substance, is not used or is reduced to an amount that does not adversely affect the environment, and the solubility in proteins and the like is reduced due to the nonuse or reduction of the amount Is supplemented by the combined use of acetic acid and tartaric acid and / or malonic acid as an organic acid, and thus has excellent cleaning and disinfecting effects and has little or no environmental impact and is highly safe Equipment cleaning / disinfecting agents can be provided.
酢酸と、酒石酸及び／又はマロン酸の割合が、重量基準で前者が１に対して後者が１〜３である場合に、上記した補完効果が最も効果的に発揮される。 When the ratio of acetic acid and tartaric acid and / or malonic acid is 1 on the basis of weight and 1 to 3 on the basis of weight, the above-mentioned complementary effect is most effectively exhibited.
本発明の第１の医療機器用洗浄消毒剤は、過酸化水素０．１〜６．０重量％、有機過酸０．１〜２．０重量％、有機酸０．５〜４０重量％を含有してなり、前記有機酸が酢酸と、酒石酸及び／又はマロン酸とからなことを特徴とする。 The first medical device cleaning / disinfecting agent of the present invention contains 0.1 to 6.0% by weight of hydrogen peroxide, 0.1 to 2.0% by weight of organic peracid, and 0.5 to 40% by weight of organic acid. And the organic acid comprises acetic acid and tartaric acid and / or malonic acid.
本発明における過酸化水素は、酸化剤として微生物の細胞タンパク質を変性又は破壊して殺菌するとともに、微生物が生成した毒素を酸化分解するものである。
過酸化水素の含有量は０．１〜６．０重量％が好ましい。過酸化水素の含有量が０．１重量％未満では上記殺菌力、毒素の分解力が不十分となり、一方、６．０重量％を越えると皮膚に接すると強い炎症を生じるなど安全性、取り扱い性に問題を生じ、薬事法上劇物となるので好ましくない。
The hydrogen peroxide in the present invention denatures or destroys microbial cell proteins as an oxidizing agent to sterilize, and oxidatively decomposes toxins produced by the microorganisms.
The content of hydrogen peroxide is preferably 0.1 to 6.0% by weight. If the hydrogen peroxide content is less than 0.1% by weight, the above bactericidal power and toxin decomposing power will be insufficient. On the other hand, if it exceeds 6.0% by weight, strong inflammation will occur when it comes into contact with the skin. This is not preferable because it causes problems in sex and becomes a deleterious substance under the Pharmaceutical Affairs Law.
有機過酸は、過酸化水素と同じく、酸化剤として上記した過酸化水素と同様の役割を果たすものである。有機過酸は過酸化水素と有機酸とが反応することにより生成するもので、その含有量は０．１〜２．０重量％が好ましい。有機過酸の含有量が０．１重量％未満では殺菌力、毒素の分解力が不十分となり、一方、２．０重量％を越えても余り効果に変化がなく、また、過酸化水素や有機酸の含有量を増大する必要が生じ、過酸化水素の場合は上記したように、安全性、取り扱い性に問題が生じ、有機酸の場合はコストアップとなる。 Like hydrogen peroxide, the organic peracid plays the same role as the above-described hydrogen peroxide as an oxidizing agent. The organic peracid is produced by a reaction between hydrogen peroxide and an organic acid, and its content is preferably 0.1 to 2.0% by weight. If the content of organic peracid is less than 0.1% by weight, the bactericidal power and the ability to decompose toxins will be insufficient. On the other hand, if the content exceeds 2.0% by weight, the effect will not change much. It is necessary to increase the content of the organic acid. In the case of hydrogen peroxide, as described above, there are problems in safety and handleability, and in the case of an organic acid, the cost is increased.
有機酸は、上記した如く、過酸化水素と反応して有機過酸を生成する。有機酸の含有量は０．５〜４０重量％が好ましい。有機酸の含有量が０．５重量％未満では過酸化水素と反応して生成する有機過酸が少なくなり、本発明の目的とする十分な効果が得られない傾向があり、一方、４０重量％を越えても余り効果に変化がなく、かえって不経済となる。
このような有機酸としては、酢酸と、酒石酸及び／又はマロン酸とを併用する。これらの併用する割合は、重量基準で酢酸が１に対して酒石酸及び／又はマロン酸が１〜３である場合に、より好ましい併用効果を発揮する。
As described above, the organic acid reacts with hydrogen peroxide to produce an organic peracid. The content of the organic acid is preferably 0.5 to 40% by weight. If the content of the organic acid is less than 0.5% by weight, the amount of the organic peracid generated by reaction with hydrogen peroxide decreases, and there is a tendency that a sufficient effect intended by the present invention cannot be obtained. Even if it exceeds 50%, there is no change in the effect, which is uneconomical.
As such an organic acid, acetic acid and tartaric acid and / or malonic acid are used in combination. The ratio of these combined use exhibits a more preferable combined effect when tartaric acid and / or malonic acid is 1 to 3 with respect to 1 for acetic acid on a weight basis.
上記過酸化水素、有機過酸、有機酸及び無機酸に通常水を加えて上記含有量の水溶液形態とされるが、必要に応じ、更に、安定剤、香料、その他の添加剤を含有することも可能である。また、本発明の医療機器用洗浄消毒剤は、そのまま又は必要に応じ５〜２００倍程度に希釈して使用される。 Usually, water is added to the hydrogen peroxide, organic peracid, organic acid and inorganic acid to form an aqueous solution with the above content, but if necessary, it may further contain stabilizers, fragrances and other additives. Is also possible. The medical device cleaning / disinfecting agent of the present invention is used as it is or after diluting to about 5-200 times as necessary.
本発明の第２の医療機器用洗浄消毒剤は、過酸化水素０．１〜６．０重量％、有機過酸０．１〜２．０重量％、有機酸０．５〜４０重量％、無機酸０．５〜２．０％を含有してなり、前記有機酸が酢酸と、酒石酸及び／又はマロン酸とからなことを特徴とする。 The second medical device cleaning and disinfecting agent of the present invention is hydrogen peroxide 0.1 to 6.0 wt%, organic peracid 0.1 to 2.0 wt%, organic acid 0.5 to 40 wt%, It contains 0.5 to 2.0% of an inorganic acid, and the organic acid is composed of acetic acid and tartaric acid and / or malonic acid.
即ち、上記第１の医療機器用洗浄消毒剤は、リン酸に代表される無機酸を使用することなく、特定の有機酸を併用することにより無機酸不使用によるタンパク質等の溶解力の低下を補完抑制したものであるが、第２の医療機器用洗浄消毒剤は、更に無機酸を含有させてタンパク質等の溶解力を高めると同時に、無機酸の含有量を環境に悪影響を与えない程度に減少させる一方、無機酸の減少によるタンパク質等の溶解力の低下を特定の有機酸の併用によって補完抑制したものである。 That is, the first medical device cleaning and disinfecting agent does not use an inorganic acid typified by phosphoric acid, but reduces the solubility of proteins and the like due to the non-use of an inorganic acid by using a specific organic acid in combination. Although supplementary suppression is performed, the second medical device cleaning / disinfecting agent further contains an inorganic acid to increase the solubility of proteins and the like, and at the same time, the content of the inorganic acid does not adversely affect the environment. On the other hand, the decrease in the dissolving power of proteins and the like due to the decrease in inorganic acid is complementarily suppressed by the combined use of a specific organic acid.
本発明における無機酸は、リン酸、硝酸、硫酸が用いられる。これらは単独で又は必要に応じ２種以上組み合わせて用いられるが、タンパク質等の溶解力の大きさからはリン酸が好ましい。無機酸の含有量は０．５〜２．０重量％が好ましく、０．５重量％未満ではタンパク質等の溶解力が不十分となり、一方、２．０重量％を越えると、特にリン酸を用いる場合には、環境への影響が無視し得なくなる。リン酸を使用する場合は、環境への影響の観点から、１．０重量％未満が好ましく、更に好ましくは０．９重量％以下である。 As the inorganic acid in the present invention, phosphoric acid, nitric acid, and sulfuric acid are used. These may be used alone or in combination of two or more as necessary, but phosphoric acid is preferred from the viewpoint of the solubility of proteins and the like. The content of the inorganic acid is preferably 0.5 to 2.0% by weight, and if it is less than 0.5% by weight, the solubility of proteins and the like is insufficient. When used, the environmental impact cannot be ignored. When phosphoric acid is used, it is preferably less than 1.0% by weight, more preferably 0.9% by weight or less, from the viewpoint of environmental impact.
以下、実施例を挙げて本発明を更に詳細に説明するが、本発明はかかる実施例のみに制限されないことは云うまでもない。
尚、以下の記載において、特に断らない限り、％は重量％である。
EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated further in detail, it cannot be overemphasized that this invention is not restrict | limited only to this Example.
In the following description, unless otherwise specified,% is% by weight.
実施例１〜３、比較例１〜４
表１の配合・組成からなる医療機器用洗浄消毒剤を調製した。尚、残部は水（ＲＯ水）で、組成物全体を１００％とした。
Examples 1-3, Comparative Examples 1-4
A medical device cleaning / disinfecting agent having the composition and composition shown in Table 1 was prepared. The balance was water (RO water), and the entire composition was 100%.
（タンパク質溶解力、炭酸カルシウム溶解力試験）
得られた実施例１〜３及び比較例１〜４で得られた医療機器用洗浄消毒剤のタンパク質溶解力及び炭酸カルシウム溶解力を下記の方法でテストした。結果を表１に示す。
(Protein solubility, calcium carbonate solubility test)
The protein dissolving power and calcium carbonate dissolving power of the medical device cleaning disinfectants obtained in Examples 1 to 3 and Comparative Examples 1 to 4 were tested by the following methods. The results are shown in Table 1.
「タンパク質溶解力試験」
ガラスプレートにアルブミン(卵製)と血漿グロブリンの混合物を水に溶解し、塗布して乾燥したものを準備し、医療機器用洗浄消毒剤を各々ＲＯ水で５０倍に希釈した液に浸漬して、たんぱく質の溶解力を大きい方から小さい方へ◎+ 、◎、◎- 、○、○- 、△、×で示す。
"Protein solubility test"
Dissolve a mixture of albumin (egg) and plasma globulin in water on a glass plate, apply and dry it, and immerse the cleaning disinfectant for medical equipment in a solution diluted 50 times with RO water. Protein solubility is shown as ◎ + , 、, -- , 、, ○ - , △, × from the largest to the smallest.
「炭酸カルシウム溶解力」
医療機器用洗浄消毒剤を各々２０ｍＬ採りＲＯ水で１０００ｍＬとして、これに炭酸カルシウムの粉末を加え、スターラーで撹拌しながら液の濁りが生じる直前の炭酸カルシウム添加量（ｇ）を測定する。
"Calcium carbonate solubility"
20 mL each of medical device cleaning disinfectant is taken up to 1000 mL with RO water, calcium carbonate powder is added thereto, and the calcium carbonate addition amount (g) immediately before the liquid becomes cloudy is measured while stirring with a stirrer.
上記表１の結果から明かなように、有機酸として酢酸と、酒石酸及び／又はマロン酸とを併用することにより、タンパク質溶解力及び炭酸カルシウム溶解力に優れた医療機器用洗浄消毒剤が得られることが分かる。これらの医療機器用洗浄消毒剤は、リン酸等の無機酸を含有していないので環境に悪影響を及ぼす恐れもない。 As is clear from the results in Table 1 above, by using acetic acid and tartaric acid and / or malonic acid as the organic acid in combination, a cleaning disinfectant for medical devices having excellent protein dissolving power and calcium carbonate dissolving power can be obtained. I understand that. Since these medical device cleaning / disinfecting agents do not contain an inorganic acid such as phosphoric acid, there is no fear of adversely affecting the environment.
実施例４〜９、比較例５〜６
表２の配合・組成に変更した他は実施例１〜３と同様にして医療機器用洗浄消毒剤を調製し、タンパク質溶解力、炭酸カルシウム溶解力試験を行った。結果を表２に示す。
Examples 4-9, Comparative Examples 5-6
A cleaning / disinfecting agent for medical devices was prepared in the same manner as in Examples 1 to 3 except that the composition and composition of Table 2 were changed, and protein solubility and calcium carbonate solubility tests were performed. The results are shown in Table 2.
上記表２の結果から明かなように、リン酸を１％未満にまで減少させても、有機酸として、酢酸と、酒石酸及び／又はマロン酸とを併用することにより、リン酸を１０％使用した比較例６と概ね同レベルのタンパク質溶解力及び炭酸カルシウム溶解力を示すことが分かる。しかも、リンの含有量は０．２８％で、比較例６に比べて１／１０以下であり、環境への悪影響が極めて小さいことが分かる。 As is clear from the results in Table 2 above, even when phosphoric acid is reduced to less than 1%, 10% phosphoric acid is used by combining acetic acid with tartaric acid and / or malonic acid as the organic acid. It can be seen that the protein dissolving power and calcium carbonate dissolving power of the same level as in Comparative Example 6 are shown. In addition, the phosphorus content is 0.28%, which is 1/10 or less compared to Comparative Example 6, and it can be seen that the adverse effect on the environment is extremely small.
（殺菌力試験）
次に、得られた実施例１〜９及び比較例１〜６で得られた医療機器用洗浄消毒剤の各種微生物に対する殺菌力を下記の方法でテストした。結果を表３、表４に示す。尚、表３、表４中「＋」は菌が死滅しなかったこと（殺菌力なし）を示し、「−」は菌が死滅した（殺菌力あり）ことを示す。
(Bactericidal test)
Next, the bactericidal activity against various microorganisms of the medical device cleaning disinfectants obtained in Examples 1 to 9 and Comparative Examples 1 to 6 was tested by the following method. The results are shown in Tables 3 and 4. In Tables 3 and 4, “+” indicates that the bacteria were not killed (no sterilizing power), and “−” indicates that the bacteria were killed (with sterilizing power).
「試験溶液の調製方法」
細菌：各試験菌株を０．２％肉エキス加普通ブイヨン［栄研化学］で３５℃、１８〜２４時間培養したものを試験菌液とした。
酵母：試験菌株をブドウ糖ペプトン培地［日本製薬］で２５℃、４８時間培養したものを試験菌液とした。
「後培養培地及び培養条件」
細菌：ＳＣＤＬＰ培地［日本製薬］、３５℃、２日間
酵母：ＧＰＬＰ培地［日本製薬］、２５℃、７日間
「試験操作」
精製水に各試験濃度に希釈した検体１０ｍＬに各試験菌液１ｍＬを加え、混合後、２０℃で一定時間作用させた。作用開始後、各試験時間後に作用試験管から後培養培地に１白金耳量移植し、培養後、試験菌の生育の有無を観察し、菌の生死を判定した。なお、対照例として精製水についても同様に試験した。
"Method for preparing test solution"
Bacteria: Each test strain was cultured in a normal bouillon with 0.2% meat extract [Eiken Chemical Co., Ltd.] at 35 ° C. for 18 to 24 hours as a test bacterial solution.
Yeast: A test bacterial solution was obtained by culturing the test strain in glucose peptone medium [Nippon Pharmaceutical Co., Ltd.] at 25 ° C. for 48 hours.
"Post-culture medium and conditions"
Bacteria: SCDLP medium [Nippon Pharmaceutical Co., Ltd.], 35 ° C., 2 days Yeast: GPLP medium [Nippon Pharmaceutical Co., Ltd.], 25 ° C., 7 days “Test operation”
1 mL of each test bacterial solution was added to 10 mL of a sample diluted to each test concentration in purified water, mixed, and allowed to act at 20 ° C. for a certain period of time. After the start of action, after each test time, 1 platinum loop was transplanted from the action test tube to the post-culture medium, and after culturing, the presence or absence of growth of the test bacteria was observed to determine the viability of the bacteria. As a control example, purified water was also tested in the same manner.
上記表３及び表４の結果から明かなように、本発明の医療機器用洗浄消毒剤は十分な殺菌力を備えていることが分かる。 As is clear from the results of Tables 3 and 4 above, it can be seen that the cleaning / disinfecting agent for medical devices of the present invention has sufficient sterilizing power.
叙上のとおり、本発明の医療機器用洗浄消毒剤は、洗浄作用及び消毒作用に優れるとともに、環境負荷が小さく、且つ安全性が高く、頗る有用性の高いものである。
As described above, the medical device cleaning / disinfecting agent of the present invention is excellent in cleaning action and disinfecting action, has a small environmental load, is highly safe, and is highly useful.
Claims (6)
The medical device cleaning and disinfecting agent according to claim 4 or 5, wherein the phosphoric acid content is less than 1% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005022820A JP2006206535A (en) | 2005-01-31 | 2005-01-31 | Washing disinfectant for medical equipment |
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| Application Number | Priority Date | Filing Date | Title |
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| JP2005022820A JP2006206535A (en) | 2005-01-31 | 2005-01-31 | Washing disinfectant for medical equipment |
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| JP2006206535A true JP2006206535A (en) | 2006-08-10 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008088062A (en) * | 2006-09-29 | 2008-04-17 | Kao Corp | Bactericide composition |
| JP2009051756A (en) * | 2007-08-24 | 2009-03-12 | Kao Corp | Bactericidal composition |
| WO2010095231A1 (en) * | 2009-02-19 | 2010-08-26 | サラヤ株式会社 | Acidic oxidant-containing composition having aluminum corrosion-suppressing effect and use thereof |
| JP2010537970A (en) * | 2007-08-30 | 2010-12-09 | イーコラブ インコーポレイティド | Storage stable low corrosive ready-to-use peroxycarboxylic acid antibacterial composition |
| JP2013515072A (en) * | 2009-12-21 | 2013-05-02 | フレッシュ・エクスプレス・インコーポレイテッド | Sterilization of articles with peracid and 2-hydroxy organic acid compositions |
| EP3797592A1 (en) * | 2019-09-25 | 2021-03-31 | Sani-Marc Inc. | Peracetic compositions, methods and kits for removing biofilms from an enclosed surface |
| KR102550050B1 (en) * | 2022-08-29 | 2023-06-30 | (주)하이진바이오컴퍼니 | disinfectant using organic peroxide and manufacturing method thereof |
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2005
- 2005-01-31 JP JP2005022820A patent/JP2006206535A/en not_active Withdrawn
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008088062A (en) * | 2006-09-29 | 2008-04-17 | Kao Corp | Bactericide composition |
| JP2009051756A (en) * | 2007-08-24 | 2009-03-12 | Kao Corp | Bactericidal composition |
| JP2010537970A (en) * | 2007-08-30 | 2010-12-09 | イーコラブ インコーポレイティド | Storage stable low corrosive ready-to-use peroxycarboxylic acid antibacterial composition |
| WO2010095231A1 (en) * | 2009-02-19 | 2010-08-26 | サラヤ株式会社 | Acidic oxidant-containing composition having aluminum corrosion-suppressing effect and use thereof |
| US8574632B2 (en) | 2009-02-19 | 2013-11-05 | Saraya Co., Ltd. | Acidic oxidant-containing composition having aluminum corrosion-suppressing effect and use thereof |
| US10736323B2 (en) | 2009-02-19 | 2020-08-11 | Saraya Co., Ltd. | Acidic oxidant-containing composition having aluminum corrosion-suppressing effect and use thereof |
| JP2013515072A (en) * | 2009-12-21 | 2013-05-02 | フレッシュ・エクスプレス・インコーポレイテッド | Sterilization of articles with peracid and 2-hydroxy organic acid compositions |
| EP3797592A1 (en) * | 2019-09-25 | 2021-03-31 | Sani-Marc Inc. | Peracetic compositions, methods and kits for removing biofilms from an enclosed surface |
| KR102550050B1 (en) * | 2022-08-29 | 2023-06-30 | (주)하이진바이오컴퍼니 | disinfectant using organic peroxide and manufacturing method thereof |
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