JPH04135559A - Disinfecting detergent for medical treating equipment for artificial dialysis or the like - Google Patents

Abstract

PURPOSE:To provide excellent disinfecting detergency and to peel and decom pose away proteins and fats by compounding a specific anion surfactant with sodium hypochlorite. CONSTITUTION:The disinfecting for medical treating equipment for artificial dialysis, etc., contains the anion surfactant of an alkyl ether sulfate ester salt or alkyl phenyl ether sulfate ester salt system, the sodium hypochlorite and the stabilizer thereof, and ethylenediaminetetraacetic acid as essential components. The specific anion has general formula. The specific anion does not decompose even if a strong alkali agent is compounded with a sodium hypochlorite soln. contg strong alkali agent. The detergency of this specific anion and the sodium hypochlorite act synergistically to provide the effect of removing the proteins and fats sticking to the inside of the piping of the equipment simultaneously with sterilization and disinfection.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to the disinfection and cleaning of medical equipment, particularly artificial dialysis machines, and their peripheral equipment.

[Prior art] Blood, lymph fluid, sweat, urine, etc. adhere to artificial dialysis machines and their peripheral equipment/equipment, etc., and these also contain proteins and fats. In particular, foreign proteins can cause death from shock and anaphylaxis. These deposits must be disinfected and cleaned as they can easily become a cause of contamination, and it is desirable to wipe and disinfect as needed in the event of contamination, and to wipe and disinfect regularly.

In addition, dirt on dialysate supply equipment, dialysate supply lines, and especially patient monitoring equipment (internal dialysate piping) can lead to bacterial growth within the pipes, which may cause patient fever due to endotoxin. The backfiltration phenomenon caused by the use of biperformance membrane dialysers has created a need for more thorough cleaning and disinfection of dialyzer piping.

Furthermore, with the recent widespread use of sodium bicarbonate dialysate, calcium salts such as calcium carbonate are precipitated in pipes, which can cause problems with patient monitoring devices, so it is necessary to take precautions to prevent such problems.

Conventionally, formalin, sodium hypochlorite, cresol soap, Sterihyde (a glutaral type drug), etc. have been mainly used as agents to disinfect and clean these deposits and deposits.

However, although these agents all have sterilizing power, they have almost no cleaning power by peeling, decomposing, and removing proteins, fats, calcium salts, etc. that adhere to tubes and the like.

Calcium salts are removed by washing with acetic acid, but this acetic acid is corrosive to metals and accelerates equipment damage. Furthermore, there are problems such as negative effects on the final treatment of wastewater and legal wastewater restrictions. However, there are many problems in using it.

[Problems to be Solved by the Invention] The present invention aims to solve the problems of conventional disinfection-cleaning agents as described above, and has extremely excellent disinfection and cleaning power, and removes proteins and fats. - The aim is to provide a disinfectant and cleaning agent for medical equipment such as artificial dialysis that can be decomposed and removed and has excellent stability.

In addition, it has a decomposition and cleaning effect on the significant dirt and bacterial growth in piping caused by low-molecular proteins removed from the blood by biperformance membrane dialyzers, which have recently become popular, and patients The aim is to prevent frequent troubles with monitoring equipment and thereby reduce the mental burden on medical staff.

Furthermore, with the spread of the above-mentioned sodium bicarbonate dialysate, it is possible to remove calcium salts such as calcium carbonate that precipitate in pipes, without having to perform acetic acid cleaning, which can cause metal corrosion and pollution problems. It also seeks to eliminate it.

[Means for solving the problem] As a result of various studies to achieve the above objective, a certain anionic surfactant was blended into a sodium hypochlorite solution as a disinfectant, and added as a metal sequestering agent. By combining ethylenediaminetetraacetate at the same time, a greater synergistic effect can be achieved than when these agents are used separately, achieving disinfection and cleaning at the same time, removing proteins and fat by peeling and decomposition, and They discovered that they could solve all the problems of conventional methods at once, including the ability to remove calcium salts.

That is, the present invention provides anionic surfactants based on alkyl ether sulfates or alkylphenyl ether sulfates, sodium hypochlorite and its stabilizer,
and a disinfectant and cleaning agent for medical equipment such as artificial dialysis, which is characterized by containing ethylenediaminetetraacetate as an essential component.

The greatest feature of the present invention is that a specific anionic surfactant is blended with sodium hypochlorite, which has been conventionally used as a disinfectant.

In other words, the sodium hypochlorite solution is a strong oxidizing agent and is made alkaline by the strong alkaline agent added as a stabilizer.

Adding a surfactant to improve its cleaning power is
This is a breakthrough in the conventional wisdom that this is impossible because the surfactant decomposes.

In other words, as a result of repeated compounding tests of various surfactants and sodium hypochlorite containing alkaline agents,
By using an alkyl ether sulfate salt or alkyl phenyl ether sulfate salt-based anionic surfactant (hereinafter simply referred to as "specific anion"), this specific anion can stably coexist with sodium hypochlorite. They discovered that the synergistic effect of the two can significantly improve the cleaning power.

This specific anion has the following general formula.

General Formula % Formula % However, in the above general formula, R represents an alkyl group having 6 to 18 carbon atoms, and n represents an integer of 5 to 10.

When anionic surfactants other than the anionic anion are mixed with a sodium hypochlorite solution containing a strong alkaline agent, they decompose due to their oxidizing power and lose their action as surfactants, and at the same time, this oxidation causes hypochlorous acid. The disinfecting effect of sodium also decreases.

The above-mentioned specific anions do not decompose even when mixed with a sodium hypochlorite solution containing a strong alkaline agent, and the detergency of this specific anion and sodium hypochlorite act synergistically. The effect of removing proteins and fats adhering to the inside of equipment piping is achieved at the same time as sterilization.

Furthermore, it is mandatory to sterilize dialysis equipment and its piping/tubing with sodium hypochlorite, and this sodium hypochlorite itself has both sterilizing and cleaning power, and the above-mentioned specific anions The detergency of the product is greatly improved by its combination.

Further, if a nonionic surfactant having relatively excellent oxidation resistance and alkali resistance is used in combination with this specific anion, the improvement in detergency can be further increased.

The nonionic surfactant is preferably a polyoxyethylene alkyl ether type surfactant, and for example, polyoxyethylene lauryl ether, which is an adduct of 5 to 10 moles of ethylene oxide, can be suitably used.

However, this nonionic surfactant has the disadvantage that it foams easily, so it is not necessarily necessary to use it in combination, and even if it is used in combination, it is preferable that the amount of the nonionic surfactant is less than half of the amount of the specific anion.

Next, sodium hypochlorite, which is blended into the cleaning agent of the present invention, is the main ingredient that has the ability to decompose disinfectants using oxygen and chlorine.

In general, in the absence of organic matter such as fat or protein, 1
~The low level of available chlorine in the SPP garden eliminates viruses, algae,
It is possible to sterilize all microorganisms, including non-spore bacteria, but the presence of organic matter significantly reduces the sterilizing ability, resulting in
This requires 0 to 100 times more effective chlorine.

In the present invention, since the purpose is to clean under conditions where fat and protein are present, the amount of sodium hypochlorite added is increased, but by adding the specific anion mentioned above, this increase is suppressed as much as possible. It is now possible to do so.

It goes without saying that a large increase in the amount of sodium hypochlorite will cause significant damage to the internal components of the device.

In addition, this sodium hypochlorite becomes unstable when the pH becomes 5 or less and generates chlorine gas, so it is always necessary to use a stabilizer such as caustic soda in combination.

Next, as the ethylenediaminetetraacetic acid salt used in the present invention, disodium salt of ethylenediaminetetraacetic acid (hereinafter simply referred to as EDTA) may be used, and this EDTA is known as a chelating agent that sequesters metal ions. .

In other words, this EDTA is formulated to remove calcium salts such as calcium carbonate, and can chelate calcium ions that are difficult to chelate. It has the effect of chelating and removing substances and at the same time preventing re-deposition.

Chelating agents other than EDTA (e.g. citric acid,
birophosphoric acid, sodium tripolyphosphate, etc.) have a pH of 3 to 5.
It chelates calcium only in the following acidic range, but it does not act as a chelating agent at all in the alkaline range, such as the detergent of the present invention.

As described above, the present invention has a specific anion, sodium hypochlorite and its stabilizer, and EDTA as essential components, and the appropriate composition thereof is as follows.

Specific anions: 5-20% Sodium hypochlorite 12% solution: 40-80% Stabilizer (NaOH 25% solution): 3-6% EDTA
...0.2-1.0% distilled water
... Remaining amount % In addition, the cleaning agent of the present invention is used by diluting the above-mentioned composition 35 to 140 times, preferably about 70 times, in actual use.The following explanation of the composition is as follows. The following description assumes this dilution.

In the above formulation, if the specific anion is less than 5%, it is difficult to improve the detergency, and even if it exceeds 20%, the improvement in effectiveness will not increase proportionally, and usually around 105 is most appropriate.

Furthermore, if the proportion of 12% sodium hypochlorite solution is less than 40%, the sterilization and cleaning power in the presence of fat and protein will decrease, while if the proportion exceeds 80%, the stability will deteriorate and the loss rate of available chlorine will increase. The most appropriate blending amount is around 60%.

Furthermore, the blending ratio of the stabilizer to stabilize sodium hypochlorite may be increased or decreased in proportion to the blending amount of sodium hypochlorite, and is usually around 3 to 6% when using a 25% caustic soda solution. is appropriate; if too much is blended, metal corrosion will occur, and if too little is blended, the stability of sodium hypochlorite will deteriorate.

Second, EDTA is effective in very small amounts; more than 1.0% is unnecessary, and less than 0.2% does not sufficiently remove calcium salts.

In addition, when a nonionic surfactant is blended, as mentioned above, a blending ratio of less than half of the specific anion is appropriate, and if the blending ratio is too high, foaming properties may occur, which is undesirable.

[Function] The present invention has the above-mentioned structure, and its main feature is that a specific anion that can coexist with the sodium hypochlorite solution is blended, and EDTA that can chelate calcium salts in the alkaline region is added. That's what I did.

As a result, specific anions and sodium hypochlorite act synergistically, and even if fat or protein is attached or deposited in the piping of medical equipment such as artificial dialysis, sodium hypochlorite disinfects and sterilizes. The force is sufficiently exerted, and due to the action of specific anions, the adhering/deposited fats and proteins are easily peeled off, decomposed, washed, and removed.

Similarly, calcium salts deposited in pipes and the like can be peeled off and easily removed by chelation with EDTA, and the effect of preventing redeposition can be obtained.

Since this calcium salt can be easily removed, conventional acetic acid cleaning is not necessary, so there is little damage to equipment due to metal corrosion, and there is no problem of environmental pollution due to acetic acid emissions.

[Example] As a specific anion, one having the following chemical structural formula was used.

Specified anionic detergent preparation Sodium hypochlorite (NaCIO) 12% solution 40%
%, 60%, and 80%, disinfectant cleaning agents were prepared in which the specific anions were blended at concentrations of 0%, 5%, 10%, and 20%, respectively.

As stabilizers, 25% caustic soda solution was mixed at 4%, and EDTA was mixed at 0.5%.

Each of these mixed liquids was diluted 70 times to prepare a cleaning immersion liquid.

Test method Artificial dialysis tubing with fat, protein, and calcium carbonate uniformly adhered to it was cut into 3.50 square slices, and then vertically divided into 2 equal parts, which were used as test pieces, and their weights were accurately weighed. .

Each of the test pieces was immersed in the cleaning immersion liquid and taken out corresponding to the 12 measurement time, dried and accurately weighed.The removal rate of deposits was determined from the difference from the weight before immersion, and the cleaning power was compared.

The results were shown in graphs as shown in FIGS. 1 to 3.

From these graphs, 60% of 12% sodium hypochlorite is sufficient, and it is not much different from 80%.
It is recognized that the cleaning power decreases slightly when the percentage is mixed.

In addition, the best blending percentage of specific anions is 10%<20%.
At 5%, the detergency decreases slightly, and at 5%, the detergency decreases considerably, but it is clear that the effect is greater than when using sodium hypochlorite alone.

An experiment was also conducted in which the specific anion content was 30%, but there was a phenomenon of re-deposition of dirt and the effect was not good.

As a result, the concentration of 12% sodium hypochlorite solution was 60
It was confirmed that the concentration of the specific anion is preferably around 10%, and that the combined use of both is extremely effective.

Further, the graph in Figure 84 is a result of a similar experiment conducted using only a specific anion, and it is shown that the cleaning effect is low when using this specific anion alone.

In other words, it is recognized that a synergistic effect is produced by using sodium hypochlorite and a specific anion in combination rather than by using them individually.

Furthermore, the graph in Figure 5 assumes that the specific anion is 10%.
% Sodium hypochlorite amount 40%, 60%, 80%
cleaning agent, and 125 sodium hypochlorite 60%
It shows the change over time for each individual case, that is, the decline in the amount of available chlorine over the number of months.

The storage conditions were as follows: in a thermostatic chamber at 36° C., with ultraviolet rays cut off.

From this graph, the combination of specific anions is effective in improving stability, and the combination of 12% sodium hypochlorite is 6
The case of 0% is judged to be the most stable.

In other words, when considering the formulation of 12% sodium hypochlorite, 80% is slightly better than 60% judging from the detergency alone, but 60% is preferable when considering stability. It can be said that the certification is correct.

[Effects of the Invention] Various effects of the present invention have been described in the explanations so far, but they are briefly listed below.

(a) The cleaning agent of the present invention has a sterilizing and disinfecting effect comparable to that of sodium hypochlorite alone.

(b) Furthermore, it has the ability to peel off and decompose fats and proteins that are attached or deposited inside the pipes, and clean them.

(C) Furthermore, it also has the effect of chelating and removing calcium salts deposited in piping and preventing re-deposition.

(d) The amount of available chlorine does not decrease over time and is excellent in stability.

These effects were achieved by the synergistic effect of co-blending specific anions and sodium hypochlorite and the combination of EDTA, which simultaneously washes and removes proteins and fats that cause bacterial growth. This method solves all the problems of the conventional method in that it disinfects and sterilizes, and also eliminates calcium salts.

As a result, dirt on the dialysate supply device, dialysate supply line, patient monitoring device (internal dialysate piping), etc. in artificial dialysis can be easily cleaned, and the cause of patient fever due to endotoxin has been eliminated, and the biperformance membrane dialysis machine It can sufficiently deal with the backfiltration phenomenon caused by use, and plays an important role in preventing secondary infections due to virus-contaminated instruments and hospital infections.

Furthermore, the cleaning agent of the present invention can also remove calcium salts deposited in pipes due to the recent spread of sodium bicarbonate dialysate, eliminating the need for conventional acetic acid cleaning, thereby significantly reducing damage to equipment, water pipes, sewers, etc. due to metal corrosion. It is also effective in preventing pollution.

As described above, the present invention has various excellent effects and is extremely useful as a bulk cleaning agent for medical equipment such as artificial dialysis.

It is a stability graph showing changes compared to the case of sodium hypochlorite alone.

(a)...Additional amount of specific anion, (b) -12% NaCl0 addition amount

[Brief explanation of drawings]

Figures 1 to 3 are graphs of the cleaning effect showing the relationship between the deposit removal rate and immersion time of test pieces in Examples, and the ts1 diagram shows the cleaning effect when 12% sodium hypochlorite is 60%. Figure 2 shows the same 80% case, Figure 3 shows the same 4
The case of 0% is shown in each case. FIG. 4 is a graph of the cleaning effect similarly shown in the case of a specific anion alone. Figure 5 shows the amount of available chlorine over time for the cleaning agent of the present invention, patent applicant Ibuki Tadashi Chemical Industry Co., Ltd.

Claims (1)

[Claims] 1. Artificial dialysis etc. characterized by containing an alkyl ether sulfate salt or alkyl phenyl ether sulfate salt-based anionic surfactant, sodium hypochlorite and its stabilizer, and ethylenediaminetetraacetate as essential components. Disinfectant cleaning agent for medical equipment.