KR100700890B1 - Gel-type mouthwash containing silver nano - Google Patents

Abstract

The present invention relates to a gel-type mouthwash composition 40, and more specifically, a gel-type mouthwash composition 40, hydrogen peroxide, carbamide peroxide, calcium peroxide. Sodium per carbonate and sodium per borate, tetra sodium pyrophosphate peroxide, glucose oxidase, dextranase, lactoperoxidase, gluten It is at least one selected from the group consisting of glaucoma lysozyme, protease and water containing the same, wherein the silver nano solution material is mixed (80) and heated (120), including 0.01 to 20% by weight. Or a gel-type mouthwash composition 40 made of a gelled tablet which has been dried to remove moisture.

Mouthwash, antibacterial, antiseptic, inflammation, plaque removal, bad breath removal,

Description

 Gel-type mouthwash containing silver nano {Nano silver contain gelatin the mouth cleaning}

1 is a block diagram of a blend 80 of a gel-type mouthwash containing silver nanoparticles of the present invention.

Figure 2 is a photograph taken in 60,000 times magnification of the cross section of the silver nano of the present invention.

Figure 3 is a photograph of an 80,000-fold magnification of the side of the silver nano of the present invention by an electron microscope.

Figure 4 is a photograph taken at 50,000 times magnification of the surface of the silver nano of the present invention.

Figure 5 is a photograph of the antimicrobial activity of the strain into which the silver nano of the present invention.

6 is Staphylococcus aureus, pneumococci, bacteria in which the silver nano of the present invention is added.

MRSA (Methicillin-Resistant Staphylococcus Aureus) Bacteria Antimicrobial Test Picture.

7 is a three-dimensional structural diagram of silver nano of the present invention.

* Description of the symbols for the main parts of the drawings *

10: mouthwash 20: silver nano

40: composition 60: container

80: Mix 100: Input Step

120: heating step 140: stirring step

160: manure step 180: slow cooling

200: moisture evaporation 220: gel

240: container 260: completion

280: Packing

The present invention relates to a gelled gel 220 type mouthwash composition 40,

More specifically, the gelled gel 220 removes moisture as a main effect of the antibacterial function of teeth, as well as the effect of removing bad breath, preventing tooth decay, and the like, which have a tooth whitening effect of the conventional fern solution. It relates to a gel-type mouthwash composition 40 made.

In general, teeth may cause diseases such as odors in the mouth, coloration of teeth, tooth decay, etc. due to drinks, food intake, and the like.

As a method for a conventional mouthwash, Korean Patent Registration No. 294515 describes a gelled gel 220 type oral cleaning foam containing a cellulose, a foaming agent, an abrasive, an organic acid, and a caries prevention agent.

However, the method is a liquid mouthwash, but only a general odor removal effect, such as showing no teeth whitening effect. In addition, Korean Patent Publication No. 93-9595 discloses an oral composition comprising peroxyacetic acid for whitening teeth.

 According to the present invention, a typical mouthwash composition 40 includes hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium per carbonate and sodium perborate, and peroxide fatigue. Tetra sodium pyrophosphate peroxide glucose oxidase, dextranase, lactoperoxidase, gluconase, lysozyme, protease and their acceptance At least one selected from the group consisting of water was used to remove the smell of the mouth and have a slight whitening effect, but did not have an anti-oral antiseptic function.

Bad breath is caused by inflammation of the oral cavity or gums, or protein or food waste in saliva is decomposed into amino acids by microorganisms in the oral cavity, and then amino acids are decomposed by deacidification enzymes or amino enzymes, causing odors. Occurs by creating a.

In addition, ingestion of garlic or onions also causes bad breath due to sulfides contained in these substances.

Plaque, on the other hand, is a white or yellowish-brown light deposit attached to the surface of a tooth, and is composed of many oral bacteria and bacterial liver substrates.

Bacterial liver matrix is composed of polysaccharides produced by bacteria, sugar protein of saliva, food residues, proteins of exudate from gums and the like, and in the bacterial liver matrix, declining epithelial cells are often mixed (80).

The plaque is formed in large quantities in parts where mechanical cleaning is incomplete, such as the cervical area, the proximal surface, the bovine, and the hothouse part.

The formation of plaques is first started by the attachment of sugar protein components in saliva onto the membrane on the surface of the teeth, where bacteria are settled and multiplied. The bacteria that form the early plaque are cocci, but as the plaque matures, the bacteria turn into fungi.

As the fungus multiplies, the plaque rapidly increases in thickness.

Recently, the streptococcus mutans, a group of chains in prag, has attracted attention as an important bacterium that causes caries. Streptococcus mutans breaks down sugar in foods to produce acid, and large amounts of glue

This is because it produces a polysaccharide called glucan.

Glucan does not dissolve well in water and is very sticky. Therefore, it is believed that glucan plays a role in attaching and stagnating plaque to the surface of teeth. In addition, plaque is a common cause of incomplete oral cleanliness and causes bad breath, caries, and periodontal disease.

Among the enzymes of the active ingredient that suppresses the generation of bad breath, the production of plaque.

 However, in the case of enzymes, the efficacy is excellent, but the stability in the liquid formulation is poor, there are many difficulties in realizing the efficacy.

As described above, the present invention relates to an easy-to-use gelled gel-type oral cleanser (10) containing silver nano (20) which greatly improves the problem of decay, deterioration and deodorization of the conventional mouthwash. Since it is mixed (80) during the preparation of the mouthwash (10) without electric sterilization or washing, it contains a strong silver nano (20) material which is economical and sterilization and sustainability is unpredictable. When administered to the (220) type oral cleanser (10) material can be consistently obtained the following excellent benefits.

   Silver nano (20) is harmless to the human body and has a sterilizing power and antibacterial power of several times stronger than chlorine series.

If so, look at the characteristics of the gel 220-type mouthwash 10 containing the silver nano (20);

1: When silver is nano-ized, the antimicrobial, sterilization, deodorization and detoxification functions are superior to any disinfectant, and the gel type 220 oral cleanser (10) containing silver nano (20) has good silver ions and far-infrared rays. It can cause blood circulation and endocrine activity and block more than 90% of the form hormone, an environmental hormone that has become a problem recently, and can have antiviral and antiallergic effects.

 2: It reacts sensitively according to the pollution level of the surrounding environment

It binds strongly to bacteria's bacterial membranes (SH, COOH, OH) and the like and destroys the bacterial cell membranes or disturbs the function of the cells and shows a continuous antiseptic action.

 Recent research has shown that 650 bacteria and viruses can be sterilized, and the proliferation suppression and antiseptic function is excellent against harmful bacteria, fungi, athlete's foot, and allergic bacteria, preventing secondary infections from other pathogens that are problematic. Silver catalyzes the conversion of oxygen into free radicals, which prevents the growth of bacteria that grow by germicidal activity.

  3: The silver nano 20 has an antistatic function and an electromagnetic wave blocking function to solve harmful electromagnetic waves, have excellent electrical conductivity, and suppress static electricity generation.

  4: The silver nano 20 is very easy to coat, mix, or administer with a substance, and is a mouthwash composition 40 of the present invention, hydrogen peroxide, carbamide peroxide, and calcium peroxide. , Sodium per carbonate and

Sodium borate (sodium per borate),

Tetra sodium pyrophosphate peroxide: glucose oxidase, dextranase, lactoperoxidase, gluconase lysozyme, and protease This is very easy.

  5: In addition, it can have good effect of negative ions and far infrared rays in the body, which makes blood circulation and endocrine activity vigorous. It also has the effect of killing oral bacteria, preventing tooth decay, relieving inflammation and lasting antibacterial effect for a long time. Can be.

The present invention relates to a gel-type mouthwash (10) mixed 80 of the silver nano 20 of the present invention when manufactured in the gel-type mouthwash (10) as described above to solve the conventional problems as described above. ,

       In the present invention, silver, which is a technique different from general silver powder or ions, is a nano-form powder or silver (Ag) solution. The particle size of the silver nano (20) mixed in 80% by weight and put into the cleaning agent is 0.01 ~ 500nm to have an excellent gel-type mouthwash having an antibacterial function, sterilization function and deodorizing effect and anion and far infrared radiation function (10) Its purpose is to make it extremely portable and have excellent antiseptic efficacy, contributing to national oral health.

In order to achieve the above object, the present invention in the gel 220 type mouthwash composition 40,

Hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, which is a common mouthwash composition 40,

Sodium perborate, tetra sodium pyrophosphate peroxide glucose oxidase, dextranase, lactoperoxidase, gluconase lysozyme, At least one selected from the group consisting of protease and water containing the same;

Here, the particle size of the silver nano 20, which is added to the detergent at 0.01 to 20% by weight based on 100% by weight of the total weight including the water, is mixed (80) at a gel diameter of 0.01 to 500 nm. Mixing (80) of the cleaning composition (40), heating (120) or dried to prepare a gelled mouthwash composition (40) made of a gelled gel 220 to remove moisture, except the silver nano-material composition The numerical value of the content of 40 will follow the content of the conventional oral composition 40.

Brief description of the drawings of the gel-type oral composition 40 containing the silver nano of the present invention for achieving the above object.

FIG. 1 is a block diagram of a mixture 80 of a gel-type mouthwash 10 containing silver nanoparticles of the present invention, wherein the above-described conventional mouthwash 10 composition 40 and purified water are put into a container, and silver is To the nano (20) in the step of injecting 100 to 0.01% by weight based on 100% by weight of the total weight of the composition 40 and water and the injected composition 40 and purified water and silver nano (20) The heating step 120 to be added to the container 60, the composition 40 is mixed well (80) and the stirring step of stirring the composition 40, water and silver nano (20) well mixed (80) (140) and the filter 120 to filter the precipitate generated during the heating 120 and the slow cooling (180) process for slow cooling it after the heating 120 to gel the oral cleaning composition in the liquid state (120) Moisture evaporation step (200) to evaporate the water by the water and the mouthwash of the gel 220 in a state where the water is evaporated to some extent Which will be put into the sacred vessel (240) and distribute them after packing (280).

The present invention relates to a gelled oral gel oral cleanser (10) used to remove foreign substances and food odors in the oral cavity after a meal as described above. You can make it easier to rinse your mouth by dissolving it or dissolving it in your mouth with water.

The present invention relates to the incorporation of silver nano (20) material, which is a substance having a strong antibacterial and bactericidal action, into a gelled gel oral cleanser (10). ) Is described in detail as follows.

 Silver, the main component of silver nano (20), has been recognized as a precious metal of high value since ancient times, and has been the object of sampling. It is not only valued as a currency but also attracted attention as an important industrial material in modern industry. Production and proportion in many ways. Silver was mined early in Europe's Mediterranean coast, where silver was produced from the Incas and Aztecs before the discovery of the Americas, and then silver from Peru and Bolivia was introduced into Europe, and the flow of silver was from 1520 to 1800.

It has grown steadily, but has declined since the discovery of large amounts of silver in the early 19th century. Currently, the world's major silver producers are Russia (13.8%), Canada (13.5%), Mexico (13%), Peru (13%), United States (11%), Australia (8%), Poland (6%). The country's silver reserves are 17 million tons, and its reserves are about 9.2 million tons. As of 2002, the amount of silver produced in our country is about 5,000 kg, which is 1.2% of the total domestic demand. It's a very small amount.

Characteristics of silver: The color of silver is gray in the case of elegant gray-white metal or powder, specific gravity is 10-12, Mohs hardness is 2.5-3, and melting (80) point is 960.5 ℃.

In particular, the melting point of silver is very important for temperature compensation of high thermometers, which is the standard of scientific and industrial temperature. Silver is the best conductor of all metals and is used extensively for contacts and other electronics. Optically, the reflectance of visible light is 90, which is one of the most excellent metals such as platinum, and pure silver does not form rust even when left in the air or heated, but it reacts with sulfur and hydrogen to make black emulsified silver. Special attention should be paid to the film of the camera.

     In addition, the mechanical properties change according to the amount of impurities (O₂) contained in the silver, and the hardness of the high-purity silver obtained by thermal annealing is Brinell hardness HBS (10/500) 25-27, tensile strength 12-16kgf / mm2. The cast strength of the cast was up to about 29 kgf / mm 2, the combustion rate was 48 to 54%, and the recrystallization temperature was 150 ° C.

    Particularly, in the case of pure silver, the processed hardened material is softened by recrystallization at normal room temperature (400), and the malleability and flexibility are abundant next to gold.

     Silver's efficacy has been used as a tool to check the imbalance of the body that one cannot feel because the gloss or color changes depending on the condition of the body when used on the body since ancient times. This fatigue or low rhythm), Dongbobogam said that it is effective in the prevention and treatment of mental disorders and women's diseases such as epilepsy and game. The five chapters are said to be comfortable, the mind and body are stabilized, and the main body records that the body is lengthened by chasing morale and lightening the body.

      Also, when the Black Plague prevailed in the Middle Ages, nobility of the black aristocrats and royals, who had many silverware and silver utensils, did not have black plague, which released silver to the extent that it was able to sterilize the Black Plague bacteria, making it relatively safe from infectious diseases. In the place where the royal family and the state guests were served, silver products were used habitually.

In order to help the understanding of the silver nano 20, the present invention will be described briefly with respect to the silver nano 20 (Nano silver) extraction method and features.

The atomic weight of silver is 107.87 amu and the fact that silver (Ag) is bactericidal has been known for a long time.

Silver nano (20) was first developed by a biotechnology company, a government-affiliated organization in our country, and was named silver nano (20) as a compound name of the brand name Na no-technology and silver. ;

  Silver nano (20) is a field of Na no-technology and is an advanced antimicrobial agent that utilizes silver's strong antibacterial and bactericidal function and excellent electrical conductivity mechanism. Silver nano (20) is unlikely to be resistant to bacteria, unlike conventional antibiotics. Silver nano (20) has been shown to kill almost all single cell germs on the ground in a short time. .

 Currently, a variety of products based on silver nano (20) consisting of powder and solution have been invented and commercialized and produced in real life.

It refers to the fine particle size of silver (Nano / nm / 10 billion / m / 10-9), or 0,000000001 meter. When one gram of silver is aged, it produces ten particles. Can be.

Therefore, Ag silver (Ag) in the form of ultra-fine particles is a new concept made by utilizing the excellent efficacy of antibacterial, deodorizing power, and longer food preservation time among the many characteristics of silver. .

 Since ancient times, silver has been recognized as a disinfecting material that not only prevents bacteria but also East and West. Currently, the extraction method of silver (20) (Age 99.9%) is added to distilled water. It generates low current at low temperature, electrolyzes compounds containing silver, and conducts electrophoresis using + and-poles of each molecule to collect silver (Ag 99.9%). In addition, liquid reduction and grinding It can be manufactured by the physical method such as and the like is used a lot of the above electrolysis method to obtain a stable silver nano (20).

Silver ions are also used in general sterilization concept machines and disinfectants, and all silver products currently used are silver obtained by decomposition, and the sterilization power of silver varies depending on the product, but can obtain up to 99%.

 The silver nano 20 injected into the gel-type oral composition 40 of the present invention acts directly on harmful bacteria as 0.01 to 500 nm silver microparticles, directly dissolves the cell membranes of harmful bacteria and interferes with the electron transfer system of the harmful bacteria. As a result, it has a certain antibacterial and antibacterial activity (99.9%). (The virus size is about 10nm.)

     The main antimicrobial mechanism of silver nano (20) is to dissolve harmful bacteria cell membranes and interact with enzymes in the cells to block the metabolic function of nutrients, ie, the influx and discharge of nutrients, and to stop the respiratory function and production of harmful bacteria. And destroys regenerating ability to kill harmful bacteria.

     In addition, the silver nano (20) by controlling the harmful bacteria by releasing the antimicrobial power continuously from the fine particles is excellent in the antimicrobial, antimicrobial sustainability.

Therefore, silver nano (20) does not produce resistance and silver nano (20) is effective to perform a surface reaction and kill all the germs 99%, particularly effective in the general E. coli or food poisoning.

   The smaller the nanoparticles, the better the bactericidal and antimicrobial activity. Based on the experimental data so far, Escherichia coli, Staphylococcus aureus, Salmonella, Vibrio bacillus, Heterogeneous bacteria, Pneumococcus, Typhoid bacillus and the most resistant MRSA Resistant Staphylococcus aureus) can be 99.9% antibacterial and sterilized.

     Even if silver exists in an ionic state or a metal state, it can be referred to as colloidal silver if it exists in a colloidal state by a solvent.

In silver nano (20) (Nano silver) is the best antibacterial silver nano particles (20) minimized.

   In addition, unlike the general chemical antibacterial or chlorine disinfectant, silver nano (20) is a pure silver ultra fine particle, has excellent antibacterial and bactericidal zone (99.9%) even at high temperature, non-toxic and non-irritating to the human body, bacteria and E. coli virus fungus It has been reported that bacteria cannot live in contact with silver nano 20 for more than 5 minutes.

Next, in order to help the understanding of the present invention, the photographs and experimental data of the cross section, the side surface, and the surface of the silver nano 20 are illustrated in the drawings.

Figure 2 is a photograph taken in 60,000 times magnification of the cross section of the silver nano of the present invention.

Figure 3 is a photograph of an 80,000-fold magnification of the side of the silver nano of the present invention by an electron microscope.

Figure 4 is a photograph taken at 50,000 times magnification of the surface of the silver nano of the present invention.

Figure 5 is a photograph of the antimicrobial activity of the strain into which the silver nano of the present invention.

6 is Staphylococcus aureus, pneumococci, bacteria in which the silver nano of the present invention is added.

MRSA (Methicillin-Resistant Staphylococcus Aureus) Bacteria Antimicrobial Test Picture.

Example 1

The main cause of this experiment is to produce silver ions stably with high purity in order to experiment with this. Electrolytic method using silver / silver current using D / C current with silver rod as a solution To prepare the silver nano (20) ionized water and 30% by weight of silver nano ionized water diluted to 100% by weight of the total weight of distilled water to prepare a 100ml silver nano solution purchased from the pharmacy
Into a pot of metal material, add 2L of Dong-A Pharmaceutical Gaglin, an oral drug, which is a quasi-drug, consisting of 0.02mg of sodium fluoride (mint), cetylpyridinium chloride, 0.05g of xylitol, 2g (dent) and the remaining water in 100ml of main ingredients. And the green solution is added to 20% by weight and stirred well, and slowly boiled for 10 hours with a weak flame to completely evaporate the water, and the gelated 220 oral cleaning solution is put in a container 240 and divided into 20 people After dissolving in water or staying in the mouth and testing, it was confirmed that a good reaction was obtained and could be sufficiently applied industrially, and thus, the present invention was completed.

In the above, the embodiments or preferred embodiments of the present invention are easily described.

Those skilled in the art to which the present invention pertains will understand that the spirit and scope of the present invention described in the claims below can be variously modified or modified within the scope of the present invention.

As described above, the present invention, as described above, the present invention is a silver nano (20) (NANO SILVER) powder or silver (Ag) solution having a number of the advantages in the body of the gel-type mouthwash (10) 0.01 to 20 By introducing the weight percent into the gel-type mouthwash composition (10) composition 40, it is possible to maintain a clean and hygienic mouth and easy to produce bad breath, bacteria, pathogens and microorganisms.

Claims (3)

In the gelled gel-type mouthwash composition 40, Hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, and sodium pyrophosphate, which are common mouthwash compositions 40 pyrophosphate peroxide One or more from the group consisting of glucose oxidase, dextranase, lactoperoxidase, glucanase lysozyme, protease and water The gel-type mouthwash containing silver nano is selected, characterized in that 0.01 to 20% by weight of the silver nano (20) material is added. The method of claim 1, Particle diameter of the silver nano (20) injected into the gel oral cleanser is a gel-type mouthwash containing silver nano, characterized in that 0.01 to 500nm. The method of claim 1,  A conventional mouthwash 10 composition 40 and purified water are added to a container, and silver nano 20 is added in an amount of 0.01 to 20% by weight based on 100% by weight of the total weight of the composition 40 and water. The heating step 120 and the input step (100) and the injected composition (40) and purified water and silver nano (20) to the container (60) so that the injected composition 40 is mixed well (80). The composition 40 and the stirring step 140 for mixing the water and the silver nano 20 well (80) and the filtering step (160) for filtering the precipitate generated during the heating 120 and slow cooling (180) In order to gel the liquid mouthwash composition after the process through the gel (220), the water evaporation step (200) of evaporating water by heating (120) and the mouthwash of the gel 220 state in which water is evaporated to some extent After the composition is put into the container 240 is completed (260) and packaged 280 characterized in that the distribution The gel is a nano-containing mouthwashes.

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