CN107582737A - A kind of compound chlorohexidene oral-cavity disinfectant and preparation method thereof - Google Patents
A kind of compound chlorohexidene oral-cavity disinfectant and preparation method thereof Download PDFInfo
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- CN107582737A CN107582737A CN201710964395.0A CN201710964395A CN107582737A CN 107582737 A CN107582737 A CN 107582737A CN 201710964395 A CN201710964395 A CN 201710964395A CN 107582737 A CN107582737 A CN 107582737A
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- chlorohexidene
- oral
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- hydrogen peroxide
- cavity disinfectant
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Abstract
The invention belongs to thimerosal field, and in particular to compound chlorohexidene oral-cavity disinfectant, further relate to the preparation method of above-mentioned thimerosal.Compound chlorohexidene oral-cavity disinfectant, it is characterised in that include the composition of following weight percentage：Chlorhexidine gluconate 0.05 0.10%, hydrogen peroxide 0.5 1.5%, Honegsukle flower P.E 1.0 2.0%, apple extract 1.0 1.5%, surfactant 0.1 0.3%, tea extract 1.0 1.5%, surplus are water.The present invention does not remain relative to the common oral-cavity disinfectant only with this single component of chlorohexidene, and this good feature of Disinfection Effect few with chlorohexidene dosage, and bactericidal effect are efficient, non-stimulated, safe.
Description
Technical field
The invention belongs to thimerosal field, and in particular to compound chlorohexidene oral-cavity disinfectant, further relate to above-mentioned thimerosal
Preparation method.
Background technology
On oral-cavity disinfectant, commercially available mainly this several best-selling product：For example Shanghai Linkwell Disinfection High-Tech Co Ltd grinds
The golden clock of system reaches chlorohexidene oral care antimicrobial fluid, its main component：Chlorhexidine gluconate, separately containing menthol, sorbierite,
Xylitol；Its shortcoming is：The main component gluconic acid chlorhexidine content of sterilization is very high, due to by oral cavity, considerably increasing
Hidden danger of the gluconic acid chlorhexidine to body harm.Because under the particular surroundings of oral cavity, anaerobic bacteria species is enriched, and number is more, single
Disinfection composition all can not effectively kill the most of anaerobic bacterias in oral cavity, bactericidal effect is not thorough.
Shandong rel health sterilization Science and Technology Ltd. discloses a kind of PCI-SLR Technology's element oral mucosa thimerosal, its main component
It is：Chlorhexidine gluconate；Its shortcoming is：The main component gluconic acid chlorhexidine content of sterilization is very high, due to by oral cavity,
Considerably increase hidden danger of the gluconic acid chlorhexidine to body harm；Because under the particular surroundings of oral cavity, anaerobic bacteria species is enriched, number
Mesh is more, and single disinfection composition all can not effectively kill the most of anaerobic bacterias in oral cavity, and bactericidal effect is not thorough.
The Shandong doctor that disappears sterilizes the clean dew of doctor's board mouth that disappears that Science and Technology Co., Ltd. releases, and its main component is：Grape
Saccharic acid chlorohexidene, its shortcoming are：The main component gluconic acid chlorhexidine content of sterilization is very high, due to by oral cavity, increasing
Hidden danger of the gluconic acid chlorhexidine to body harm is added；Because under the particular surroundings of oral cavity, anaerobic bacteria species is enriched, and number is more,
Single disinfection composition all can not effectively kill the most of anaerobic bacterias in oral cavity, and bactericidal effect is not thorough.
Therefore, it is necessary to be improved for the deficiency of the said goods, it is low to research and develop a kind of gluconic acid chlorhexidine content, effectively
Complicated for oral environment, anaerobic bacteria is enriched, the good compound chlorohexidene oral-cavity disinfectant of bactericidal effect.
The content of the invention
In order to solve above-mentioned technical problem, the invention provides a kind of compound chlorohexidene oral-cavity disinfectant, mainly adopt
Carried out with two kinds of disinfectants of chlorohexidene and hydrogen peroxide compound.Under conditions of content of hydrogen peroxide is very low, it can be played and killed
The oxidation of bacterium, the effect of the bigger performance macromolecular disinfectant chlorhexidine gluconate of and can, complete two kinds of disinfectants
It is preferably compound.
Compound chlorohexidene oral-cavity disinfectant provided by the present invention, include the composition of following weight percentage：
Chlorhexidine gluconate 0.05-0.10% hydrogen peroxide 0.5-1.5%
Honegsukle flower P.E 1.0-2.0% apple extracts 1.0-1.5%
Surfactant 0.1-0.3% tea extracts 1.0-1.5%
Surplus is water.
Preferably, compound chlorohexidene oral-cavity disinfectant, including following components in percentage by weight：
Chlorhexidine gluconate 0.05-0.08% hydrogen peroxide 0.5-1.0%
Honegsukle flower P.E 1.5-2.0% apple extracts 1.0-1.2%
Surfactant 0.1-0.2% tea extracts 1.0-1.2%
Surplus is water.
It is furthermore preferred that compound chlorohexidene oral-cavity disinfectant, including following components in percentage by weight：
The hydrogen peroxide 1.0% of chlorhexidine gluconate 0.05%
The apple extract 1.0% of Honegsukle flower P.E 2.0%
The tea extract 2% of surfactant 0.1%
Surplus is water.
Surfactant is specially：AEO or Tween 80 it is any.
Hydrogen peroxide is pharmaceutical grade, and its volumetric concentration is 50%.
The preparation method of compound chlorohexidene oral-cavity disinfectant, comprises the following steps：
（1）Chlorhexidine gluconate and hydrogen peroxide are stirred into soluble in water stir evenly A liquid is made；
（2）Honegsukle flower P.E, tea extract, apple extract are added to the water stirring B liquid is made；
（3）A liquid and B liquid are mixed, surfactant is added, stirs, obtain compound chlorohexidene oral-cavity disinfectant.
Chlorohexidene can be combined with saliva glycoprotein as a kind of wide-spectrum bactericide, so that facing adhesion protein is reduced,
Prevent bacterial plaque from being formed.In addition, chlorohexidene can also be combined with bacterial cell exo polysaccharides, make bacterium be not easy to be adsorbed onto on acquisition film, reach
To the purpose for preventing and reducing periodontosis and dental caries.The addition of hydrogen peroxide can produce bubble in the oral cavity, substantially increase
Killing to oral cavity anaerobium, while the white-skinned face function of tooth is effectively increased again.Honeysuckle, apple extract can effectively increase
Add the mouthfeel of this product.
The present invention is with chlorohexidene, hydrogen peroxide（Hydrogen peroxide）, Honegsukle flower P.E, tea extract, apple extract, table
Face activating agent mutually compounds as raw material, and the oral-cavity disinfectant of gained has the characteristics that：
（1）Compare with the common only oral-cavity disinfectant with this single component of chlorohexidene, washed in thimerosal of the invention
Must safe dosage be only common chlorohexidene dosage 10-50%, reduce the potential side effect that chlorohexidene is brought to human body, greatly
Ground reduces production cost.Reason is analyzed, is after compounding chlorohexidene and hydrogen peroxide in the present invention, not only to the sterilization in oral cavity
Effect particularly anaerobic bacteria is played a good role, and the content of chlorohexidene is reduced while Disinfection Effect is ensured；
The effect of its main cause is the addition of hydrogen peroxide, and one side itself can play restraining and sterilizing bacteria；Another aspect hydrogen peroxide
Produce bubble in the oral cavity, greatly effectively kill the anaerobic bacteria of complex environment in oral cavity so that chlorohexidene and hydrogen peroxide this
The bactericidal effect of two kinds of materials is effectively cooperateed with, and is greatly promoted the bactericidal effect of single chlorohexidene so that both
Material is effectively compounded.
（2）The thimerosal of the present invention, is detected according to the Ministry of Public Health《Disinfection technology standard》（Version in 2002）, in 19-21 DEG C of bar
Under part, act on 1 minute, quantitative kill is carried out to Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa stoste and is tested.Through 3
Secondary repetition experiment shows that thimerosal of the invention is excellent to three kinds of above-mentioned bacterium killing effects, and specific implementation is shown in detailed experiment
Example.
（3）The addition of surfactant solves the problems, such as that mouthfeel is astringent so that mouthfeel is more preferably；Honegsukle flower P.E conduct
A kind of Chinese herbal medicine, its addition use, and solve the problems such as swelling and aching of gum excessive internal heat.
Embodiment
The present invention is further described with reference to specific embodiment, so that those skilled in the art knows more about
The present invention, but and it is not so limited the present invention.
Embodiment 1
The formula of compound chlorohexidene oral-cavity disinfectant is as follows（Unless otherwise specified, it is weight percentage below, following examples
It is same）：
Chlorhexidine gluconate 0.05%, hydrogen peroxide 5%, Honegsukle flower P.E 3%, tea extract 3%, apple extract 3%,
Surfactant 0.4%, remaining is purified water.
The step of preparation is：
（1）Chlorhexidine gluconate and hydrogen peroxide are stirred into soluble in water stir evenly A liquid is made；
（2）Honegsukle flower P.E, tea extract, apple extract are added to the water stirring B liquid is made；
（3）A liquid and B liquid are mixed, surfactant is added, stirs, obtain compound chlorohexidene oral-cavity disinfectant.Each raw material
Parts by weight are as disclosed above.
In embodiment 2-4, main component is shown in table below, and surplus is water.
Embodiment 2-4 data are shown in Table shown in lattice.
For the product in embodiment 1-4, detect according to the Ministry of Public Health《Disinfection technology standard》（Version in 2002）, 19 DEG C-
Under the conditions of 21 DEG C, act on 1 minute, quantitative kill is carried out to Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa stoste and is tried
Test.Tested through 3 repetitions, calculate sterilization logarithm value and kill logarithm value（Specifically it see the table below）.
Calculate the viable bacteria concentration of each group（cfu/ml）, and it is scaled logarithm value（N）, killing logarithm is then calculated as follows
Value:
Kill the logarithm value of logarithm value (KL)=control group mean viable concentration（No）- test group viable bacteria concentration logarithm value（Nx）
When calculating killing logarithm value, 2 significant digits value is taken, Figure correction can be carried out.If sterilizing test group is disinfected
Clump count is averagely produced afterwards, and during less than or equal to 1, it kills logarithm value, that is, is more than or equal to control group mean viable concentration before experiment
Logarithm value.
Escherichia coli are killed with testing inspection sterilization logarithm value
Testing inspection sterilization logarithm value is killed to staphylococcus aureus
Testing inspection sterilization logarithm value is killed to pseudomonas aeruginosa
Claims (6)
1. compound chlorohexidene oral-cavity disinfectant, it is characterised in that include the composition of following weight percentage：
Chlorhexidine gluconate 0.05-0.10% hydrogen peroxide 0.5-1.5%
Honegsukle flower P.E 1.0-2.0% apple extracts 1.0-1.5%
Surfactant 0.1-0.3% tea extracts 1.0-1.5%
Surplus is water.
2. compound chlorohexidene oral-cavity disinfectant as claimed in claim 1, it is characterised in that
Chlorhexidine gluconate 0.05-0.08% hydrogen peroxide 0.5-1.0%
Honegsukle flower P.E 1.5-2.0% apple extracts 1.0-1.2%
Surfactant 0.1-0.2% tea extracts 1.0-1.2%
Surplus is water.
3. compound chlorohexidene oral-cavity disinfectant as claimed in claim 1, it is characterised in that
The hydrogen peroxide 1.0% of chlorhexidine gluconate 0.05%
The apple extract 1.0% of Honegsukle flower P.E 2.0%
The tea extract 2% of surfactant 0.1%
Surplus is water.
4. compound chlorohexidene oral-cavity disinfectant as claimed in claim 1, it is characterised in that surfactant is specially：Fat
Alcohol APEO or Tween 80 it is any.
5. compound chlorohexidene oral-cavity disinfectant as claimed in claim 1, it is characterised in that hydrogen peroxide is pharmaceutical grade, its volume
Concentration is 50%.
6. the preparation method of compound chlorohexidene oral-cavity disinfectant as claimed in claim 1, comprises the following steps：
（1）Chlorhexidine gluconate and hydrogen peroxide are stirred into soluble in water stir evenly A liquid is made；
（2）Honegsukle flower P.E, tea extract, apple extract are added to the water stirring B liquid is made；
（3）A liquid and B liquid are mixed, surfactant is added, stirs, obtain compound chlorohexidene oral-cavity disinfectant.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125180A (en) * | 2018-10-15 | 2019-01-04 | 山东麦德森医疗科技有限公司 | A kind of preparation and its detection test method of Traditional Chinese medicinal hand lotion |
| CN111973629A (en) * | 2020-07-15 | 2020-11-24 | 湖北华冠中科生物药业有限公司 | Wound disinfection flushing fluid and preparation method thereof |
Citations (3)
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| CN101292945A (en) * | 2008-05-21 | 2008-10-29 | 南方李锦记有限公司 | Composition with efficacy of clearing oral cavity foreign flavor and refreshing foul breath |
| CN101766183A (en) * | 2009-01-07 | 2010-07-07 | 沙巧云 | Sanitary disinfectant |
| CN104739685A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Gargle containing chlorhexidine gluconate and preparation method thereof |
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2017
- 2017-10-17 CN CN201710964395.0A patent/CN107582737A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101292945A (en) * | 2008-05-21 | 2008-10-29 | 南方李锦记有限公司 | Composition with efficacy of clearing oral cavity foreign flavor and refreshing foul breath |
| CN101766183A (en) * | 2009-01-07 | 2010-07-07 | 沙巧云 | Sanitary disinfectant |
| CN104739685A (en) * | 2013-12-26 | 2015-07-01 | 上海利康消毒高科技有限公司 | Gargle containing chlorhexidine gluconate and preparation method thereof |
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| 广州蕙帆医疗科技: "http://blog.kq88.com/101523.html", 《氯己定-广州蕙帆医疗科技的博客-KQ88口腔博客》 * |
| 李乡状主编: "《健康养生指南》", 31 January 2006 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109125180A (en) * | 2018-10-15 | 2019-01-04 | 山东麦德森医疗科技有限公司 | A kind of preparation and its detection test method of Traditional Chinese medicinal hand lotion |
| CN111973629A (en) * | 2020-07-15 | 2020-11-24 | 湖北华冠中科生物药业有限公司 | Wound disinfection flushing fluid and preparation method thereof |
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Application publication date: 20180116 |