CN111973629A - Wound disinfection flushing fluid and preparation method thereof - Google Patents
Wound disinfection flushing fluid and preparation method thereof Download PDFInfo
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- CN111973629A CN111973629A CN202010679960.0A CN202010679960A CN111973629A CN 111973629 A CN111973629 A CN 111973629A CN 202010679960 A CN202010679960 A CN 202010679960A CN 111973629 A CN111973629 A CN 111973629A
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- hydrogen peroxide
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- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 40
- 239000012530 fluid Substances 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 238000011010 flushing procedure Methods 0.000 title abstract description 15
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 80
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims abstract description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960002152 chlorhexidine acetate Drugs 0.000 claims abstract description 10
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 8
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 8
- 239000002562 thickening agent Substances 0.000 claims abstract description 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 21
- 239000011259 mixed solution Substances 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 14
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 12
- 239000000661 sodium alginate Substances 0.000 claims description 12
- 235000010413 sodium alginate Nutrition 0.000 claims description 12
- 229940005550 sodium alginate Drugs 0.000 claims description 12
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 11
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 11
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 11
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 11
- 239000000243 solution Substances 0.000 claims description 9
- 238000005406 washing Methods 0.000 claims description 7
- 230000000249 desinfective effect Effects 0.000 claims description 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 5
- 239000004327 boric acid Substances 0.000 claims description 5
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 230000001954 sterilising effect Effects 0.000 abstract description 7
- 206010052428 Wound Diseases 0.000 description 32
- 208000027418 Wounds and injury Diseases 0.000 description 32
- 238000005303 weighing Methods 0.000 description 10
- 238000013268 sustained release Methods 0.000 description 9
- 239000012730 sustained-release form Substances 0.000 description 9
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 7
- 241000193449 Clostridium tetani Species 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 229940031705 hydroxypropyl methylcellulose 2910 Drugs 0.000 description 5
- 229940113601 irrigation solution Drugs 0.000 description 5
- 241000193468 Clostridium perfringens Species 0.000 description 4
- 241000193830 Bacillus <bacterium> Species 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 229910021538 borax Inorganic materials 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000004328 sodium tetraborate Substances 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000193155 Clostridium botulinum Species 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 238000001266 bandaging Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229960003943 hypromellose Drugs 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- -1 preferably Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Abstract
The invention provides a wound disinfection flushing fluid and a preparation method thereof, the wound disinfection flushing fluid comprises 20-30% of hydrogen peroxide slow-release agent, 2-4% of chlorhexidine acetate, 0.1-0.5% of thickening agent and the balance of water by mass percent of 100%, wherein the hydrogen peroxide slow-release agent is prepared by mixing hydroxypropyl methylcellulose and hydrogen peroxide, and can slowly release the hydrogen peroxide at a wound, so that the long-acting sterilization and bacteriostasis effects are achieved.
Description
Technical Field
The invention relates to the technical field of disinfection cleaning agents, and particularly relates to a wound disinfection flushing fluid and a preparation method thereof.
Background
The skin is an important organ of the human body, has an important biological barrier function, covers the surface of the human body, and prevents the interior of the human body from directly contacting with the external environment, but the skin is mostly contacted with the external environment, so the skin surface is often injured. The conventional wound treatment means is surface cleaning and disinfection and then bandaging, and the purpose of self-healing is achieved through self-repair of a human body. However, for some special care situations, such as deep wounds or operation wounds, the conventional cleaning and disinfecting liquid can only clean and disinfect the surface of the wound, cannot reach the deep layer, has poor disinfection effect, and the deep wound is also easily infected with specific pathogenic bacteria, such as anaerobic bacteria like tetanus bacillus, clostridium tetani, clostridium botulinum and the like, and once the pathogenic bacteria are not cleared in time, serious harm or even death is caused to the human body.
Disclosure of Invention
In view of the above, the invention provides a wound disinfection irrigation fluid capable of slowly releasing a bactericide at a wound, creating an aerobic environment and avoiding propagation of anaerobic pathogenic bacteria and a preparation method thereof.
The technical scheme of the invention is realized as follows: the invention provides a wound disinfection washing fluid, which comprises the following components in percentage by mass of 100:
on the basis of the technical scheme, preferably, each component comprises the following components in percentage by mass of 100 percent:
on the basis of the technical scheme, preferably, each component comprises the following components in percentage by mass of 100 percent:
on the basis of the above technical scheme, preferably, the water is purified water.
On the basis of the technical scheme, preferably, the thickening agent comprises sodium alginate and sodium carboxymethyl cellulose, wherein the sodium alginate: the mass ratio of the sodium carboxymethylcellulose is 1: (2.5-4).
Still preferably, the preparation method of the hydrogen peroxide sustained release agent comprises the following steps: mixing hydroxypropyl methylcellulose with 3% hydrogen peroxide, heating to 50-60 deg.C under sealed condition, stirring for 10-20min under heat preservation, and cooling to 20-30 deg.C to obtain hydrogen peroxide sustained release agent, wherein the hydroxypropyl methylcellulose: the mass ratio of 3% hydrogen peroxide is 1: (4-8).
On the basis of the technical scheme, preferably, the methoxyl content of the hypromellose is 28-30%.
In the technical scheme, the hydrogen peroxide sustained release agent can slowly release hydrogen peroxide with the sterilization and disinfection functions at the wound for a long time, meanwhile, the hydrogen peroxide is decomposed to generate oxygen, an aerobic environment is created for the wound, the reproduction of anaerobic bacteria is inhibited, and the hydroxypropyl methylcellulose is used as a sustained release carrier, so that the rapid release of the hydrogen peroxide is effectively prevented.
In the technical scheme, the chlorhexidine acetate is used as the sterilizing disinfectant which is directly contacted with the wound, and plays a role in broad-spectrum sterilization.
The invention also adopts the composition compounded by sodium alginate and sodium carboxymethylcellulose as the thickening agent, on one hand, the sodium alginate and connective tissue at the wound interact to form a net structure, thereby retaining the hydrogen peroxide slow-release agent, so that the long-acting slow-release sterilization and disinfection effect is achieved, meanwhile, the sodium carboxymethylcellulose has certain thixotropy, the macromolecules of the sodium alginate slow-release agent generate a recovery effect, a three-dimensional structure can be formed, the effective components in the disinfectant can be retained and stored, and a protective film can be formed on the surface of the mucous membrane, thereby playing a further protective role.
The invention also provides a preparation method of the wound disinfection washing fluid, which comprises the following steps:
step one, mixing a thickening agent and water, heating to 40-50 ℃, keeping the temperature, stirring for 1 +/-0.5 h, cooling to 20-30 ℃, sequentially adding a hydrogen peroxide slow-release agent and chlorhexidine acetate, and stirring for 1-2h to obtain a first mixed solution;
and step two, adjusting the pH value of the first mixed solution to 6.0-7.0 to obtain the wound disinfection washing solution.
On the basis of the above technical solution, preferably, boric acid or borax is used to adjust the pH value of the first mixed solution in the second step.
Compared with the prior art, the wound disinfection irrigation solution has the following beneficial effects:
(1) the wound disinfection flushing fluid can be used for flushing and disinfecting the surface of a wound, and after flushing, the disinfection flushing fluid can stay at the wound, hydrogen peroxide with a sterilization and disinfection effect is continuously released by utilizing the slow release effect of the hydrogen peroxide slow release agent, and oxygen can be released after the hydrogen peroxide is decomposed, so that the wound is in an aerobic environment for a long time, the propagation of highly pathogenic anaerobic bacteria is effectively inhibited, the time is won for the subsequent wound treatment, and the infection risk is reduced;
(2) the thickening agent in the disinfection flushing fluid can enable a wound to form a network-shaped protective layer more easily, and the hydrogen peroxide slow-release agent is convenient to stay in the network-shaped structure, so that external bacteria are prevented from continuously invading, further infection of the wound can be prevented, meanwhile, long-acting hydrogen peroxide can be provided, and the effects of sterilization and bacteriostasis are achieved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
Respectively weighing 10g of hydroxypropyl methylcellulose 2910 and 40g of 3% hydrogen peroxide, mixing, adding into a high-pressure glass reaction bottle, heating to 50 ℃, keeping the temperature and stirring for 10min, and cooling to 20 ℃ to obtain 48g of hydrogen peroxide sustained release agent.
Weighing 0.03g of sodium alginate, 0.07g of sodium carboxymethylcellulose and 77.9g of water, mixing and heating to 40 ℃ in a three-necked bottle, preserving heat and stirring for 30min, cooling to 20 ℃, sequentially adding 20g of hydrogen peroxide slow-release agent and 2g of chlorhexidine acetate, stirring for 1h to obtain a first mixed solution, and slowly adding trace boric acid to adjust the pH value of the first mixed solution to 6.0 to obtain the wound disinfection flushing fluid.
Example 2
Respectively weighing 10g of hydroxypropyl methylcellulose 2910 and 80g of 3% hydrogen peroxide, mixing, adding into a high-pressure glass reaction bottle, heating to 60 ℃, keeping the temperature, stirring for 20min, and cooling to 20 ℃ to obtain 96g of hydrogen peroxide sustained release agent.
Weighing 0.1g of sodium alginate, 0.4g of sodium carboxymethylcellulose and 65.5g of water, mixing and heating to 50 ℃ in a three-necked bottle, preserving heat and stirring for 90min, cooling to 30 ℃, sequentially adding 30g of hydrogen peroxide slow-release agent and 4g of chlorhexidine acetate, stirring for 2h to obtain a first mixed solution, and slowly adding trace borax to adjust the pH value of the first mixed solution to 7.0 to obtain the wound disinfection flushing fluid.
Example 3
Respectively weighing 10g of hydroxypropyl methylcellulose 2910 and 50g of 3% hydrogen peroxide, mixing, adding into a high-pressure glass reaction bottle, heating to 55 ℃, keeping the temperature and stirring for 15min, and cooling to 25 ℃ to obtain 58g of hydrogen peroxide sustained release agent.
Weighing 0.05g of sodium alginate, 0.15g of sodium carboxymethylcellulose and 73.8g of water, mixing and heating to 45 ℃ in a three-necked bottle, preserving heat and stirring for 60min, cooling to 25 ℃, sequentially adding 24g of hydrogen peroxide slow-release agent and 2g of chlorhexidine acetate, stirring for 1.5h to obtain a first mixed solution, and slowly adding trace boric acid to adjust the pH value of the first mixed solution to 6.5 to obtain the wound disinfection flushing fluid.
Example 4
Respectively weighing 10g of hydroxypropyl methylcellulose 2910 and 70g of 3% hydrogen peroxide, mixing, adding into a high-pressure glass reaction bottle, heating to 58 ℃, keeping the temperature, stirring for 12min, and cooling to 25 ℃ to obtain 76g of hydrogen peroxide sustained release agent.
Weighing 0.09g of sodium alginate, 0.31g of sodium carboxymethylcellulose and 67.6g of water, mixing and heating to 48 ℃ in a three-necked bottle, preserving heat and stirring for 90min, cooling to 25 ℃, sequentially adding 28g of hydrogen peroxide slow-release agent and 4g of chlorhexidine acetate, stirring for 2h to obtain a first mixed solution, and slowly adding trace borax to adjust the pH value of the first mixed solution to 6.0 to obtain the wound disinfection flushing fluid.
Example 5
Respectively weighing 10g of hydroxypropyl methylcellulose 2910 and 60g of 3% hydrogen peroxide, mixing, adding into a high-pressure glass reaction bottle, heating to 54 ℃, keeping the temperature, stirring for 16min, and cooling to 25 ℃ to obtain 69g of hydrogen peroxide sustained release agent.
Weighing 0.075g of sodium alginate, 0.225g of sodium carboxymethylcellulose and 71.7g of water, mixing and heating to 55 ℃ in a three-necked bottle, preserving heat and stirring for 80min, cooling to 25 ℃, sequentially adding 25g of a hydrogen peroxide slow-release agent and 3g of chlorhexidine acetate, stirring for 1.5h to obtain a first mixed solution, and slowly adding trace boric acid to adjust the pH value of the first mixed solution to 6.8 to obtain the wound disinfection flushing fluid.
Examples 1-5 and a commercially available wound irrigation solution were each subjected to experimental comparison.
Anaerobic bacteria disinfection test:
according to the requirements of the disinfection technical specification, the bactericidal logarithm value of the tubercle bacillus, the clostridium tetani and the clostridium perfringens is respectively determined, and the determination result is as follows:
| log sterilization value | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Comparative example |
| Mycobacterium tuberculosis | 5.24 | 5.42 | 5.36 | 5.38 | 5.51 | 5.11 |
| Clostridium tetani | 5.44 | 5.58 | 5.41 | 5.50 | 5.58 | 5.06 |
| Clostridium perfringens | 5.32 | 5.31 | 5.44 | 5.25 | 5.51 | 5.05 |
Slow-release anaerobic bacteria disinfection test:
the rinse solutions of examples 1 to 5 and the comparative example were exposed to air, left standing for 4 hours, and then the bactericidal log values of tubercle bacillus, clostridium tetani and clostridium perfringens were measured according to the requirements of disinfection specifications, and the measurement results were as follows:
| log sterilization value | Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | Comparative example |
| Mycobacterium tuberculosis | 5.12 | 5.15 | 5.12 | 5.13 | 5.14 | 4.23 |
| Clostridium tetani | 5.08 | 5.18 | 4.99 | 5.05 | 5.06 | 4.15 |
| Clostridium perfringens | 5.01 | 5.12 | 5.15 | 4.89 | 5.08 | 4.33 |
In conclusion, the wound disinfection irrigation solution has a good disinfection effect on anaerobic bacteria, and after a certain period of exposure, the wound disinfection irrigation solution still has a good disinfection effect on the anaerobic bacteria, while the sterilization performance of the commercially available irrigation solution is greatly reduced.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (6)
1. The wound disinfection washing fluid is characterized by comprising the following components in percentage by mass of 100 percent:
20 to 30 percent of hydrogen peroxide slow release agent
Chlorhexidine acetate 2-4%
0.1 to 0.5 percent of thickening agent
The balance being water.
2. The wound disinfecting washing solution as claimed in claim 1, wherein the thickener is a combination of sodium alginate and sodium carboxymethylcellulose, and the ratio of sodium alginate: the mass ratio of the sodium carboxymethylcellulose is 1: (2.5-4).
3. The wound disinfecting washing solution as claimed in claim 1, wherein the preparation method of the hydrogen peroxide slow-release agent comprises: mixing hydroxypropyl methylcellulose with 3% hydrogen peroxide, heating to 50-60 ℃ under a closed condition, keeping the temperature, stirring for 10-20min, and cooling to 20-30 ℃ to obtain a hydrogen peroxide slow release agent, wherein the hydroxypropyl methylcellulose: the mass ratio of 3% hydrogen peroxide is 1: (4-8).
4. A wound disinfecting irrigant according to claim 3 wherein the hydroxypropyl methylcellulose has a methoxyl content of 28-30%.
5. A method of preparing a wound disinfecting irrigant solution according to claim 1, comprising the steps of:
step one, mixing a thickening agent and water, heating to 40-50 ℃, keeping the temperature, stirring for 1 +/-0.5 h, cooling to 20-30 ℃, sequentially adding a hydrogen peroxide slow-release agent and chlorhexidine acetate, and stirring for 1-2h to obtain a first mixed solution;
and step two, adjusting the pH value of the first mixed solution to 6.0-7.0 to obtain the wound disinfection washing solution.
6. The method of preparing a wound-disinfecting rinse solution according to claim 5, wherein boric acid is used to adjust the pH of the first mixture in the second step.
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| CN202010679960.0A CN111973629A (en) | 2020-07-15 | 2020-07-15 | Wound disinfection flushing fluid and preparation method thereof |
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| CN202010679960.0A CN111973629A (en) | 2020-07-15 | 2020-07-15 | Wound disinfection flushing fluid and preparation method thereof |
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