WO2022126629A1

WO2022126629A1 - Liquid adhesive bandage and preparation method therefor

Info

Publication number: WO2022126629A1
Application number: PCT/CN2020/137700
Authority: WO
Inventors: 吴克
Original assignee: 江苏奇力康皮肤药业有限公司
Priority date: 2020-12-18
Filing date: 2020-12-18
Publication date: 2022-06-23

Abstract

A liquid adhesive bandage, comprising the following component in percentage by weight: 15-25 parts of ethyl cellulose, 10-20 parts of carboxymethyl chitosan, 5-15 parts of hydroxyethyl cellulose, 5-10 parts of hydroxypropyl methyl cellulose, 10-15 parts of a polyvinylpyrrolidone-vinyl acetate copolymer, 1-5 parts of a plasticizer, 5-15 parts of hydrogen peroxide, 30-40 parts of ethanol, 40-50 parts of ethyl acetate, 0.5-1 part of borneol, 10-15 parts of propylene glycol, and 35-60 parts of distilled water, wherein the ethyl cellulose, the carboxymethyl chitosan, the hydroxyethyl cellulose, the hydroxypropyl methyl cellulose, and the polyvinylpyrrolidone-vinyl acetate copolymer are used as a combined film-forming agent. The ethyl cellulose improves film flexibility and elasticity. The hydroxyethyl cellulose is used for improving film adhesion. The hydroxypropyl methyl cellulose, the polyvinylpyrrolidone-vinyl acetate copolymer, and the hydrogen peroxide are used in the film to form through holes for improving air permeability.

Description

A kind of liquid band-aid and preparation method thereof

technical field

The invention belongs to the technical field of medical devices, and particularly relates to a liquid band-aid and a preparation method thereof.

Background technique

Small-area wounds in life are usually bandaged with band-aids. Although it can protect the wound surface, it also has certain drawbacks. For example, the bandaging of the wound surface in special parts such as joints is easy to deform and fall off, and it needs to be replaced repeatedly, which may cause secondary damage to the wound. The air permeability is poor, and the water vapor and sweat secreted by the wound cannot seep out in time, which will soak the local skin and easily lead to secondary infection of bacteria, and gauze or band-aid dressing cannot completely isolate the wound from contact with the outside world, which may easily lead to dust or water. It penetrates into the wound and is not conducive to wound recovery. Therefore, the research of liquid Band-Aid came into being, and the research on it is also deepening. However, the inventor found that the existing Band-Aid has the following defects:

At present, liquid Band-Aids mostly use a single permeability modifier, which has insufficient air permeability, and when the water-soluble polymer is used as the film-forming material, although it has excellent water absorption and swelling properties, the film is brittle and has poor adhesion. At present, the liquid Band-Aid cannot have the characteristics of better film flexibility, good adhesion, good water absorption and swelling, and good air permeability.

In view of the deficiencies in the prior art, it is necessary to provide a liquid Band-Aid and a preparation method thereof.

SUMMARY OF THE INVENTION

In view of the deficiencies in the prior art, the main purpose of the present invention is to provide a liquid Band-Aid, using ethyl cellulose, carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, Polyvinylpyrrolidone-vinyl acetate copolymer is used as a joint film-forming agent, and hydrogen peroxide is used as a gas permeability modifier, so that the liquid Band-Aid has the characteristics of film flexibility, adhesion, water absorption and swelling, and air permeability.

In order to realize the above-mentioned purpose of the present invention, the present invention provides the following technical solutions:

A liquid Band-Aid, comprising the following components by weight:

15-25 parts of ethyl cellulose, 10-20 parts of carboxymethyl chitosan, 5-15 parts of hydroxyethyl cellulose, 5-10 parts of hydroxypropyl methyl cellulose, polyvinylpyrrolidone-vinyl acetate copolymer 10-15 parts, plasticizer 1-5 parts, hydrogen peroxide 5-15 parts, ethanol 30-40 parts, ethyl acetate 40-50 parts, borneol 0.5-1 part, propylene glycol 10-15 parts; distilled water 35-60 parts ; Wherein, the ethyl cellulose, carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone-vinyl acetate copolymer are used as joint film-forming agents, and ethyl cellulose improves the Film flexibility and elasticity, the hydroxyethyl cellulose is used to improve film adhesion, hydroxypropyl methylcellulose, polyvinylpyrrolidone-vinyl acetate copolymer and hydrogen peroxide are used to form through holes in the film to improve air permeability .

The plasticizer is diethyl phthalate.

The preparation method of the liquid Band-Aid comprises the following steps:

1) take by weighing the ethanol of formula amount, ethyl acetate and place in the first container and mix;

2) in the above-mentioned mixture, add the plasticizer of formula quantity and stir and dissolve;

3) then slowly adding ethyl cellulose into the described first container containing solvent ethanol and ethyl acetate under stirring, until fully wetted and dissolved, to obtain the first solution;

4) add the distilled water of formula amount in the second container;

5) take by weighing the carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrrolidone-vinyl acetate copolymer of the formula amount and stir to dissolve in the second container to obtain the second solution; then Adding the hydrogen peroxide of the formula amount to the second solution;

6) take the borneol of formula amount and grind it into fine powder and place in the 3rd container, dissolve with the propylene glycol of formula amount to obtain borneol liquid;

7) Mix the first solution, the second solution and the Borneol solution and stir to obtain a liquid Band-Aid.

One of the technical solutions in the above-mentioned technical solutions has the following advantages or beneficial effects:

The present invention adopts ethyl cellulose, carboxymethyl chitosan, water-soluble hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrrolidone-vinyl acetate copolymer as a film-forming material, and the ethyl cellulose dissolves After ethanol and ethyl acetate, a uniform ethyl cellulose film is formed. The ethyl cellulose film is a porous polymer film with many small nano-scale pores, water-soluble carboxymethyl chitosan, hydroxyethyl cellulose Ethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrrolidone-vinyl acetate copolymer are embedded in the nano-scale holes of ethyl cellulose film to form good flexibility and elasticity, strong adhesion, water absorption and swelling and breathability Good composite film.

The ethyl cellulose film has good flexibility and elasticity, and can prevent the contamination of the wound by external bacteria;

Water-soluble carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose and polyvinylpyrrolidone-vinyl acetate copolymer make the liquid Band-Aid swellable;

Carboxymethyl chitosan exerts anti-inflammatory and hemostatic effects to promote rapid wound healing;

Water-soluble hydroxyethyl cellulose is used to improve the adhesiveness of the composite film and the adhesive ability of the liquid Band-Aid;

Hydroxypropyl methylcellulose and polyvinylpyrrolidone-vinyl acetate copolymer are used to form through holes in the composite film and play an excellent role in air permeability. They are good air permeability improvers; hydrogen peroxide releases oxygen by releasing its own disproportionation reaction to achieve The air permeability improver further improves the air permeability of the composite film of the liquid Band-Aid through the synergistic effect of hydroxypropyl methylcellulose, polyvinylpyrrolidone-vinyl acetate copolymer and hydrogen peroxide.

The hydrogen peroxide has the effect of bactericidal and anti-inflammatory, and the synergistic effect of the hydrogen peroxide and the carboxymethyl chitosan improves the anti-inflammatory and bactericidal functions of the liquid band-aid.

The use of borneol as an analgesic to reduce painful irritation makes the liquid band-aid gentler.

Detailed ways

It should be understood that terms such as "having", "comprising" and "including" as used herein do not assign the presence or addition of one or more other combinations.

Example 1

A liquid Band-Aid, comprising the following components by weight:

15 parts of ethyl cellulose, 10 parts of carboxymethyl chitosan, 5 parts of hydroxyethyl cellulose, 5 parts of hydroxypropyl methyl cellulose, 10 parts of polyvinylpyrrolidone-vinyl acetate copolymer, diphthalate 1 part of ethyl ester, 5 parts of hydrogen peroxide, 30 parts of ethanol, 40 parts of ethyl acetate, 0.5 part of borneol, 10 parts of propylene glycol; 35 parts of distilled water.

The preparation method of the liquid Band-Aid comprises the following steps:

4) add the distilled water of formula in the second container;

Ethyl cellulose is referred to as EC, generally insoluble in water, but soluble in different organic solvents, with good thermal stability, extremely low ash content when burning, little stickiness or astringency, and can form a tough film that remains stable at low temperatures. It can maintain flexibility, good flexibility, and the film-forming body is elastic and has good tensile strength. This product is safe and non-toxic, has strong anti-biological properties, and is metabolically inert. It is used as the main film-forming material. Ethyl cellulose (EC) has the advantages of no odor, no toxicity, good hydrophobicity and easy solubility in organic solvents, and is widely used in the field of pharmaceutical preparations. After EC is dissolved in an organic solvent as a film-forming material, a uniform film with good protective properties can be formed by a phase inversion method. Slowly add ethyl cellulose into a container containing volatile solvents ethanol and ethyl acetate under stirring until it is completely wetted and dissolved to form a flexible and elastic uniform film. Due to the use of volatile solvents Ethanol and ethyl acetate, the film forming speed is fast and the time is short.

Chitosan has good film-forming properties and is a commonly used biofilm-forming material. It also has the functions of bacteriostatic, hemostasis, healing, and analgesia. It can promote the division and cell division of epithelial cells, fibroblasts and other cells. The growth of extracellular matrix significantly accelerates wound healing and reduces scarring. Carboxymethyl chitosan is a water-soluble chitosan derivative with many properties, such as strong antibacterial properties, preservation of freshness, an amphoteric polyelectrolyte, etc. It has many applications in cosmetics, medicine, etc. One of the most studied chitosan derivatives in recent years, its stable properties, antibacterial and anti-infection, are of great significance in medicine and health care products.

Hydroxypropyl methyl cellulose (Hypromellose), also known as hypromellose, is a kind of non-ionic cellulose mixed ether. Soluble in water and some solvents, such as appropriate proportion of ethanol/water, propanol/water, etc., almost insoluble in absolute ethanol, ether, acetone; swelling into a clear or slightly turbid colloidal solution in cold water, and the aqueous solution has surface activity . High transparency and stable performance, the dissolution of HPMC in water is not affected by pH value. It has good adhesion and film-forming properties, and can be used as adhesive and film-forming agent, and is a widely used multifunctional auxiliary material.

Hydrogen peroxide has a very good pore-forming effect. Hydrogen peroxide releases oxygen by releasing its own disproportionation reaction to achieve the effect of air permeability improver.

Vinylpyrrolidone-vinyl acetate copolymer is also an alcohol-soluble and ideal film-forming material, with good non-toxic and tasteless, no irritation to the skin, no pollution, close contact with the skin, easy to degrade naturally and other excellent properties. nature. Vinylpyrrolidone-vinyl acetate copolymer is completely soluble in water, also soluble in ethanol, isopropanol, propylene glycol, glycerol, low molecular weight polyethylene glycol and other solvents, esters and ketones, slightly soluble in ether and Hydrocarbon solvents.

Vinylpyrrolidone-vinyl acetate copolymer is a highly cross-linked polymer material with a three-dimensional network structure, which can be used as an air permeability improver.

Hydroxyethyl cellulose (HEC), chemical formula (C2H6O2)n, is a white or light yellow, odorless, nontoxic fibrous or powdery solid composed of alkaline cellulose and ethylene oxide (or chlorohydrin) It is prepared by etherification and belongs to non-ionic water-soluble cellulose ethers. Since HEC has surface activity in pharmaceutical solid and liquid preparations, it has good properties such as thickening, suspending, dispersing, emulsifying, binding, protecting moisture, forming films and providing protective colloid effects, and can be used as adhesives, surface active agents, etc. agent, colloid protective agent, dispersant, emulsifier and dispersion stabilizer, etc. Hydroxyethyl cellulose is insoluble in common organic solvents, easily soluble in cold water and hot water, can provide solutions with a wide range of viscosity, and can prepare solutions with different viscosity ranges. HEC has exceptionally good salt solubility for electrolytes, and is widely used in coatings, inks, fibers, dyeing, papermaking, cosmetics, pesticides, mineral processing, oil extraction and medicine.

Using ethyl cellulose, carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrrolidone-vinyl acetate copolymer as film-forming material, ethyl cellulose is dissolved in ethanol and acetic acid After ethyl ester, a uniform ethyl cellulose film is formed, and the ethyl cellulose film has many small nano-scale pores, water-soluble carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, The polyvinylpyrrolidone-vinyl acetate copolymer is embedded in the nano-scale pores of the ethyl cellulose membrane to form a composite membrane. The ethyl cellulose film has good flexibility and elasticity, and can prevent the contamination of the wound by external bacteria; water-soluble carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose and polyvinylpyrrolidone- The vinyl acetate copolymer makes the liquid band-aid have water absorption and swelling; the water-soluble carboxymethyl chitosan plays an anti-inflammatory and hemostatic effect, which promotes the rapid healing of the wound; the water-soluble hydroxyethyl cellulose is used to improve the adhesion of the composite film It can improve the bonding ability of liquid Band-Aid; water-soluble hydroxypropyl methylcellulose and water-soluble polyvinylpyrrolidone-vinyl acetate copolymer are used to form through holes in the composite film and play an excellent ventilation effect, which is a good In addition, hydrogen peroxide releases oxygen by releasing its own disproportionation reaction to achieve the effect of air permeability improver, and the synergistic effect of hydroxypropyl methylcellulose and polyvinylpyrrolidone-vinyl acetate copolymer and hydrogen peroxide further improves the liquid The breathability of the Band-Aid's composite film. At the same time, hydrogen peroxide has the effect of bactericidal and anti-inflammatory, and its synergistic effect with the carboxymethyl chitosan improves the anti-inflammatory and bactericidal functions of the liquid band-aid. In addition, there is catalase in human tissue, which is an enzyme that catalyzes the decomposition of hydrogen peroxide into oxygen and water. The self-disproportionation reaction of hydrogen peroxide is an exothermic reaction. Under the action of catalase on the surface of skin wounds, it accelerates The reaction heat is generated, the local temperature rises, the volatilization of the solvent is accelerated, and the film forming and curing speed is accelerated. The composite protective film formed after the solvent volatilizes has certain toughness, and has remarkable waterproof, breathable and protective effects. Liquid Band-Aids use borneol as an analgesic to reduce painful irritation, making the Liquid Band-Aids gentler. Through the synergistic effect of the above-mentioned components, a liquid band-aid with good flexibility and elasticity, strong adhesive force, good water absorption and swelling property and good air permeability can be obtained.

Example 2

20 parts of ethyl cellulose, 15 parts of carboxymethyl chitosan, 10 parts of hydroxyethyl cellulose, 8 parts of hydroxypropyl methyl cellulose, 13 parts of polyvinylpyrrolidone-vinyl acetate copolymer, diphthalate 3 parts of ethyl ester, 10 parts of hydrogen peroxide, 35 parts of ethanol, 45 parts of ethyl acetate, 0.7 parts of borneol, 12 parts of propylene glycol; 48 parts of distilled water.

The preparation method of the liquid Band-Aid is as in Example 1.

Example 3

25 parts of ethyl cellulose, 20 parts of carboxymethyl chitosan, 15 parts of hydroxyethyl cellulose, 10 parts of hydroxypropyl methyl cellulose, 15 parts of polyvinylpyrrolidone-vinyl acetate copolymer, diphthalate 5 parts of ethyl ester, 15 parts of hydrogen peroxide, 40 parts of ethanol, 50 parts of ethyl acetate, 1 part of borneol, 15 parts of propylene glycol; 60 parts of distilled water.

The preparation method of the liquid Band-Aid is as in Example 1.

Comparative Example 1

The difference between this comparative example and Example 3 is that it does not contain carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, and polyvinylpyrrolidone-vinyl acetate copolymer. The plan is as follows:

A liquid Band-Aid, comprising the following components by weight: 25 parts of ethyl cellulose, 5 parts of diethyl phthalate, 15 parts of hydrogen peroxide, 40 parts of ethanol, 50 parts of ethyl acetate, 1 part of borneol, and 15 parts of propylene glycol share.

The preparation method of the liquid Band-Aid comprises the following steps:

Weigh the ethanol and ethyl acetate of the formula and place them in the first container and mix them uniformly;

In above-mentioned mixture, add the diethyl phthalate of formula amount and stir and dissolve;

Then under stirring, slowly add ethyl cellulose into the first container containing solvent ethanol and ethyl acetate until it is completely wetted and dissolved to obtain the first solution; then add the hydrogen peroxide of the formula amount to the first solution ;

Take the borneol of the formula amount and grind it into fine powder and place it in the second container, and dissolve it with the propylene glycol of the formula amount to obtain the borneol liquid;

After mixing the first solution and the Borneol liquid, stir evenly to obtain a liquid Band-Aid.

Comparative Example 2

The difference between this comparative example and Example 3 is that it does not contain ethyl cellulose. The plan is as follows:

A liquid Band-Aid, comprising the following components by weight:

20 parts of carboxymethyl chitosan, 15 parts of hydroxyethyl cellulose, 10 parts of hydroxypropyl methyl cellulose, 15 parts of polyvinylpyrrolidone-vinyl acetate copolymer, 5 parts of diethyl phthalate, 15 parts of hydrogen peroxide parts, 40 parts of ethanol, 50 parts of ethyl acetate, 1 part of borneol, 15 parts of propylene glycol; 60 parts of distilled water.

The preparation method of the liquid Band-Aid comprises the following steps:

In the above-mentioned mixture, add the diethyl phthalate of formula amount, stir and dissolve to obtain the first solution;

Add the distilled water of formula amount in the first container;

Weigh the carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrrolidone-vinyl acetate copolymer in the formula amount and stir to dissolve in the second container to obtain the second solution;

After mixing the first solution and the second solution, stir evenly, and then add the hydrogen peroxide of the formula to obtain a mixed solution;

Take the borneol of the formula and grind it into fine powder and place it in the third container, and dissolve it with the propylene glycol of the formula to obtain the borneol liquid;

The mixed solution and the Borneol solution are mixed and stirred evenly to obtain a liquid Band-Aid.

Comparative Example 3

The difference between this comparative example and Example 3 is that it does not contain hydrogen peroxide, hydroxypropyl methylcellulose and polyvinylpyrrolidone-vinyl acetate copolymer. The plan is as follows:

A liquid Band-Aid, comprising the following components by weight:

25 parts of ethyl cellulose, 20 parts of carboxymethyl chitosan, 15 parts of hydroxyethyl cellulose, 5 parts of diethyl phthalate, 40 parts of ethanol, 50 parts of ethyl acetate, 1 part of borneol, 15 parts of propylene glycol parts; 60 parts of distilled water.

The preparation method of the liquid Band-Aid comprises the following steps:

Then slowly add ethyl cellulose into the first container containing solvent ethanol and ethyl acetate under stirring, until it is completely wetted and dissolved to obtain the first solution;

Add the distilled water of the formula to the second container;

Weigh the carboxymethyl chitosan and hydroxyethyl cellulose of the formula amount and stir in the second container to dissolve to obtain the second solution;

The first solution, the second solution and the Borneol solution are mixed and stirred evenly to obtain a liquid Band-Aid.

Comparative Example 4

The difference between this comparative example and Example 3 is that it does not contain hydroxyethyl cellulose. The plan is as follows:

A liquid Band-Aid, comprising the following components by weight:

25 parts of ethyl cellulose, 20 parts of carboxymethyl chitosan, 10 parts of hydroxypropyl methyl cellulose, 15 parts of polyvinylpyrrolidone-vinyl acetate copolymer, 5 parts of diethyl phthalate, 15 parts of hydrogen peroxide , 40 parts of ethanol, 50 parts of ethyl acetate, 1 part of borneol, 15 parts of propylene glycol; 60 parts of distilled water.

The preparation method of the liquid Band-Aid comprises the following steps:

Add the distilled water of the formula to the second container;

Weigh the carboxymethyl chitosan, hydroxypropyl methylcellulose, polyvinylpyrrolidone-vinyl acetate copolymer of the formula amount and stir to dissolve in the second container to obtain the second solution; then add the hydrogen peroxide of the formula amount to the second solution. solution;

Test Example 1

Take about 4g of each liquid Band-Aid obtained by the solutions provided in Examples 1-3 and Comparative Examples 1-4, cast it, spread it, dry it naturally, and prepare it into a film, and then compare the effects. The three aspects of water vapor transmission rate are compared. Among them, the sterility is checked according to the sterility inspection method of the second appendix XIH of the Chinese Pharmacopoeia in 2010, and the tensile strength of the film is tested according to the GB13022-91 plastic film tensile property test method. ; Water vapor transmission rate is tested according to YY/T0471.2-2004 contact wound dressing test method for water vapor transmission rate. The results are shown in Table 1.

Table 1 Performance of the liquid Band-Aid provided by Example 1-3 and Comparative Example 1-4

As can be seen from Table 1, compared with Comparative Examples 1-4, Example 1-3 adopts ethyl cellulose, carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone-acetic acid The vinyl ester copolymer is combined as a film-forming material. The ethyl cellulose film has good flexibility and elasticity, which can prevent the contamination of the wound by external bacteria; water-soluble hydroxypropyl methylcellulose and water-soluble polyvinylpyrrolidone-vinyl acetate Ester copolymers are used to form through holes in composite films and play an excellent role in air permeability. They are good air permeability improvers. Hydrogen peroxide releases oxygen by releasing its own disproportionation reaction to achieve the effect of air permeability improvers. It is also a good air permeability improver. Through the synergistic effect of hydroxypropyl methylcellulose, polyvinylpyrrolidone-vinyl acetate copolymer and hydrogen peroxide, the air permeability of the composite film of the liquid Band-Aid is further improved.

Test case 2

200 cases of volunteers with skin damage were randomly divided into 2 groups, namely the test group and the control group, with 100 people in each group. The ventilation effect, anti-inflammatory effect, isolation effect, water absorption swelling property and adhesive force were evaluated, and the results are shown in Table 2.

Table 2 Test results of experimental group and control group

组别group	透气效果Breathable effect	消炎效果Anti-inflammatory effect	隔离效果isolation effect	吸水溶胀性water swellability	粘接力Adhesion
试验组test group	9898	9595	9797	9696	9797
对照组control group	8787	8282	8585	8686	8888

As can be seen from Table 2, the liquid Band-Aid of Example 3 has better ventilation effect, anti-inflammatory effect, isolation, water absorption swelling property and adhesive force.

It can be seen that ethyl cellulose, carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone-vinyl acetate copolymer are used as joint film-forming agents, and hydrogen peroxide is used as air permeability improvement The liquid Band-Aid has the characteristics of film flexibility, adhesion, water absorption and swelling, and breathability. Water-soluble carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose and polyvinylpyrrolidone-vinyl acetate copolymer make the liquid Band-Aid have better water absorption and swelling; water-soluble hydroxyethyl Cellulose is used to improve the adhesiveness of the composite film and improve the adhesiveness of the liquid Band-Aid.

Although the embodiment of the present invention has been disclosed as above, it is not limited to the application listed in the description and the embodiment, it can be applied to various fields suitable for the present invention, and those skilled in the art can easily Additional modifications are implemented, therefore, the invention is not limited to the specific details and embodiments shown and described herein without departing from the general concept defined by the appended claims and the scope of equivalents.

Claims

A liquid Band-Aid is characterized in that: it comprises the following components in parts by weight: 15-25 parts of ethyl cellulose, 10-20 parts of carboxymethyl chitosan, 5-15 parts of hydroxyethyl cellulose, hypromellose 5-10 parts of base cellulose, 10-15 parts of polyvinylpyrrolidone-vinyl acetate copolymer, 1-5 parts of plasticizer, 5-15 parts of hydrogen peroxide, 30-40 parts of ethanol, 40-50 parts of ethyl acetate, 0.5-1 part of borneol, 10-15 parts of propylene glycol; 35-60 parts of distilled water; wherein, the ethyl cellulose, carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinylpyrrolidone -Vinyl acetate copolymer as a joint film-forming agent, ethyl cellulose improves film flexibility and elasticity, the hydroxyethyl cellulose is used to improve film adhesion, hydroxypropyl methyl cellulose, polyvinylpyrrolidone-acetic acid Vinyl ester copolymer and hydrogen peroxide are used to form through-holes in the film to improve air permeability.
The liquid Band-Aid according to claim 1, wherein the plasticizer is diethyl phthalate.
A preparation method of liquid Band-Aid as claimed in claim 1, is characterized in that, comprises the following steps:

1) take by weighing the ethanol and ethyl acetate of formula quantity and place in the first container and mix well;

2) in the above-mentioned mixture, add the plasticizer of formula quantity and stir and dissolve;

3) then slowly adding ethyl cellulose into the described first container containing solvent ethanol and ethyl acetate under stirring, until fully wetted and dissolved, to obtain the first solution;

4) add the distilled water of formula in the second container;

5) take by weighing the carboxymethyl chitosan, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, polyvinyl pyrrolidone-vinyl acetate copolymer of the formula amount and stir to dissolve in the second container to obtain the second solution; then Adding the hydrogen peroxide of the formula amount to the second solution;

6) take the borneol of formula amount and grind it into fine powder and place in the 3rd container, dissolve with the propylene glycol of formula amount to obtain borneol liquid;

7) Mix the first solution, the second solution and the Borneol solution and stir to obtain a liquid Band-Aid.
The preparation method of claim 3, wherein the plasticizer is diethyl phthalate.