JPS59196825A - Protecting agent for mucous membrane - Google Patents

Abstract

PURPOSE:A protecting agent for mucous membranes, obtained by dissolving sodium polyacrylate in a solvent consisting essentially of a water, and capable of protecting the mucous membranes, e.g. rectum, vagina, oral cavity, and nasal cavity, etc. CONSTITUTION:A protecting agent for mucous membranes obtained by dissolving sodium polyacrylate, preferably >=10,000 viscosity-average polymerization degree (Pv) in water alone or a mixed solvent of water and a little another solvent, e.g. ethanol, ethylene glycol or glycerol, without irritating the skin. The above-mentioned solvent containing <=50wt% preferably >=5wt% liquid polyhydric alcohol, e.g. ethylene glycol, facilitates the dissolving action of the sodium polyacrylate, and the above-mentioned alcohol having the wetting property provides excellent protecting action on the mucous membranes due to the difficult drying property of the liquid. Another component, e.g. an emulsifying agent, germicide, hormonal agent or nutrient for the mucous membranes, etc. in a small amount may be added to the above-mentioned solution.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a mucosal protective agent for protecting the mucous membranes of the rectum, vaginal cavity, nasal cavity, etc.k) The mucosal protective agent according to the present invention comprises sodium polyacrylate. , which is characterized by being dissolved in a solvent containing water as a main component.

The invention will be explained in detail below. The viscosity average degree of polymerization (P~) of the sodium polyacrylate used in the present invention is preferably 10,000 or more. Below this,
The amount of resin required for a given viscosity increases, and therefore the amount of resin that adheres to the treated area increases, causing discomfort to the person to be treated. Other solvents, such as alcohols,
It can be dissolved in a mixed solvent of esters, etc. and water. Examples of the other solvents include ethanol.

Examples include ethylene glycol, glycerol, amyl acetate, etc. Especially ethylene glycol as a solvent.

The work of dissolving monosodium polyacrylate containing liquid polyhydric alcohol such as glycerin, erythrint, pentite, pinacol, etc. at s+BjMt% (hereinafter simply referred to as %) or less, preferably at least 5% is facilitated, and the alcohol has a wetting action. Since the liquid has the following characteristics, the liquid does not dry out and the mucous membrane protection properties are extremely good.

The solution of sodium polyacrylate has a molecular weight of 5,000 to 5,000 at room temperature.
A viscosity of about 15,000 cps is suitable for protecting the mucous membranes. The above viscosity is, for example, l)'
In the case of sodium polyacrylate with y = 35,000, a concentration of about 1 to 2% can be obtained.

Other ingredients such as an emulsifier,
A small amount of fungicides, hormones, mucosal nutrients, other drugs, zinc white, fragrances, two pigments, etc. may be added.

The sodium polyacrylate has little irritation to mucous membranes,
It is completely harmless to humans and animals, and the solution has a viscosity suitable for protecting mucous membranes, so it can be used during sexual intercourse, enema, oral cavity,
It is applied during procedures to the nasal cavity, vaginal cavity, rectum, anus, etc. to provide local lubricity and effectively protect the local mucous membranes, and it can also be applied to areas prone to shoe blisters to prevent shoe blisters. It is also useful for other purposes.

Example 1 15% of sodium polyacrylate with Pv=38,000
The aqueous solution exhibits a viscosity of 10,200 C/25°C.

This solution provides a mucosal protectant with favorable viscosity and lubricity.

Example 2 Sodium polyacrylate with pv=30,000 is dissolved in water containing 5% ethylene glycol to make 5%. The viscosity of the solution is 500 Cps, 725'C. 1100 tp of coumarin are added to the solution as fragrance.

To obtain a mucosal protective agent that is harmless to humans and animals, has an aroma, and provides good fx lubricity.

Example 6 1.7 parts by weight of sodium acrylate with Pv = 55,000 5 parts by weight of oyohiboxyethylene argylphenol ether were dispersed in 20 parts by weight of glycerin, and the mixture was poured into 75 parts by weight of water and dissolved with stirring. Viscosity 13.000 tps
/ Obtain a mucosal protectant at 25°C. This product has high wettability and exhibits good mucosal protective effect.

Patent applicant Toshi Nakashima's procedural amendment May 15, 1980 Commissioner of the Patent Office Kazuo Wakasugi 14 [Display of items] 1981 Patent Application No. 70936 2. Name of the invention Mucosal protective agent :3 Person making corrections Relationship with 411 cases Special fj’l applicant 4. 〒467　〒467 8. Contents of amendment 1, page 2, line 17 Insert the following sentence after "...can be obtained."

"Furthermore, considering the pH that is suitable for mucous membranes, it is desirable to adjust the sodium polyacrylate solution to a pT:I of 5.5 to 65. Usually, inorganic acids such as hydrochloric acid and acetic acid or organic acids are used to adjust the pH. , it is desirable to use a polymeric acid such as polyacrylic acid as the acid that causes less viscosity reduction in the sodium polyacrylate solution.'' 2, Page 3, line 12, ``indicates...'' is replaced with ``...'' ... and the pH is 9. When the pH of the aqueous solution is adjusted to 5.5 with polyacrylic acid, the viscosity becomes 10.100 cps/25°C. Corrected to 1.

　　　　　d

Claims (1)

[Claims] A mucosal protective agent made by dissolving sodium polyacrylate in a solvent mainly composed of water.