JPH09143060A - Composition for water-containing gel plaster base - Google Patents

Abstract

PROBLEM TO BE SOLVED: To readily obtain the above composition excellent in transdermal absorption of medicine, favorably bonding to skin, rich in safety and useful as a base material for external medicine preparation, etc., by combinedly using an N-vinylacetamide homopolymer. SOLUTION: This composition consists essentially of (A) an N-vinylacetamide homopolymer, (B) a copolymer of a polyacrylic acid monovalent salt and/or an acrylic acid monovalent salt with acrylic acid, (C) a water-soluble aluminum salt and (D) water. Moreover, the component A content is preferably 0.1-30wt.% and the component B is preferably 0.005-1.0wt.% expressed in terms of aluminum and e.g,. aluminum hydroxide is preferably used as the component B.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention has a high gel strength,
Topical pharmaceutical preparations such as anti-inflammatory and analgesic poultices, etc., which have high adhesive strength and are easy to prepare without producing syneresis, hydrous gels for medical devices such as bioadhesives, wound protectants, therapeutic pads, etc. The present invention relates to a patch base composition and one used as a base.

[0002]

Water-containing gel patch bases such as poultices are generally natural water-soluble polymers such as tragacanth gum, karaya gum, gum arabic, sodium alginate, mannan, gelatin, pectin or polyacrylic acid, polyacrylate. A synthetic polymer such as polyvinyl alcohol or polyacrylamide is used, and a moisturizing agent such as polyhydric alcohol, water, a tackifier or the like is added to the composition.

Since the above-mentioned natural water-soluble polymer is a natural product, its quality is not stable, and phenomena such as contamination by contaminants and deterioration by impurities occur. On the other hand, since the synthetic polymer is a synthetic product, it does not have the above problems. However, synthetic polymers lack cohesive properties, and when they are used, the skeleton of the gel becomes weak, and the resulting hydrogel patch base causes so-called sagging in the summer and adhesive residue on the skin. The problem arises that In order to avoid this, various crosslinking treatments have been performed. For example,
Japanese Unexamined Patent Publication No. 53-115413 discloses a method in which a monovalent polyacrylic acid salt is dispersed in glycerin, and an aluminum salt is added thereto to prepare a hydrogel, and Japanese Unexamined Patent Publication No. 54-106598. Discloses a method of preparing a hydrogel by adding a sparingly soluble aluminum salt to an aqueous solution of polyacrylic acid monovalent salt in the presence of an organic acid.

[0004]

However, the above-mentioned acrylic acid-based polymers have poor solvent-philicity and tackiness, so that when the gel is applied on a non-woven fabric, the solvent in the gel is said to be behind. Was causing problems. Further, when used as a patch base, a paste becomes sticky at the time of peeling, and when exposed to high humidity, it becomes difficult for the gel to be sticky and to maintain a constant quality. The present invention has been made in view of such circumstances, and by using an N-vinylacetamide homopolymer in combination, the solvent retention is good, the adhesiveness to the skin is high, and the drug is transdermally absorbed. It is an object of the present invention to provide a composition for a hydrogel patch base having high properties and a base.

[0005]

Means for Solving the Problems In view of such circumstances, as a result of intensive studies, the composition for a water-containing gel patch base of the present invention has the following A to D in order to achieve the above object. It was found that the initial purpose can be achieved by containing the components as essential components. (A) N-vinylacetamide homopolymer. (B) Polyacrylic acid monovalent salt and / or copolymer of acrylic acid monovalent salt and acrylic acid. (C) Water-soluble aluminum salt. (D) water.

That is, the inventors of the present invention have conducted extensive research mainly on N-vinylacetamide homopolymers, and as a result, polyacrylic acid monovalent salts and / or acrylic acid monovalent salts and acrylic acid co-polymerized with them. The inventors have found that the initial object can be achieved by using a coalesced product, using a water-soluble aluminum salt as the cross-linking agent, and compounding water, and have reached the present invention. The base of the hydrogel patch of the present invention is essentially a hydrogel because the liquid retained between the skeletons of the gel has water as a main component.

The N-vinylacetamide homopolymer as the component A is blended in order to impart effective solvent retention and high tackiness. The polymer is odorless and has a high affinity with solvents, especially alcohols. Further, since it is nonionic, changes in physical properties due to salts in sweat, ionic drugs, additives, etc. are small, so that the adhesiveness to the skin is appropriately maintained. The amount of the N-vinylacetamide homopolymer added was 0.
It is 1 to 30% by weight, and if it is less than 0.1% by weight, solvent retention and skin adhesiveness are not expressed, and if it is more than 30% by weight, the viscosity at the time of compounding tends to be too high and molding processing tends to be difficult Is seen. The polyacrylic acid monovalent salt and / or the copolymer of acrylic acid monovalent salt and acrylic acid as the component B are added to obtain effective gel strength.

The component B is preferably added in an amount of 0.5 to 50% by weight, more preferably 1 to 15% by weight, in the resulting composition for a water-containing gel patch base.
It is. If the amount of the component B is less than 0.5% by weight, crosslinking tends to be insufficient, the skeleton of the gel becomes weak, and the resulting water-containing gel patch base tends to have poor shape retention. On the contrary, if it exceeds 50% by weight, the water-containing gel patch base becomes too hard, the adhesion to the skin becomes weak, and the molding process tends to be difficult. Examples of the monovalent acrylic acid salt include alkali metal salts such as sodium salt and potassium salt, alkanolamine salts such as ethanolamine, diethanolamine, methyldiethanolamine and triethanolamine, and ammonium salts.
For example, they can be used alone or in combination. That is, the acrylic acid-based polymer, which is the component B, provides a cross-linking point with aluminum, the N-vinylacetamide homopolymer exhibits gel retention of a solvent such as polyhydric alcohol, and these are blended. A water-containing gel in which the solvent is maintained at a high concentration can be obtained. This is a great feature of the present invention.

The water-soluble aluminum salt as the component C acts as a cross-linking agent for polyacrylic acid monovalent salt and polyacrylic acid, and is more trivalent than divalent metal salt among various metal salts. Metal salts have faster cross-linking speed,
Moreover, it was adopted from the viewpoint of being superior to other metal salts in terms of safety and discoloration, and these can be used alone or in combination without any problem. In this case, the water-soluble aluminum salt, as aluminum,
It is preferable to use it so that it will be contained in the hydrogel adhesive patch base composition in an amount of 0.005 to 1.0% by weight. If the amount of aluminum salt is less than 0.005% by weight, the crosslinking will be insufficient and the skeleton of the gel will be weakened. The base of the resulting hydrogel patch will have adhesive residue on the skin and shape retention at high temperature. Tend to get worse. On the contrary, if it exceeds 1.0% by weight, the hydrogel adhesive patch base becomes too hard, the adhesion to the skin becomes weak, and the molding process tends to become difficult.

Aluminum compounds such as aluminum hydroxide and hydroxides such as magnesium aluminum hydroxide,
Alternatively, normal salts of inorganic or organic acids such as aluminum chloride, aluminum sulfate, dihydroxyaluminum aminoacetate, kaolin, aluminum stearate or their basic salts, double salts such as aluminum alum, and sodium aluminate. Aluminates, inorganic aluminum complex salts and organic aluminum chelate compounds, synthetic hydrotalcite, magnesium metasilicate aluminate, magnesium aluminate silicate are included. These aluminum compounds may be those which are readily soluble in water or those which are sparingly soluble in water. When an aluminum salt having a slow dissolution rate is used, the gelling reaction is accelerated by adding an acid to the gelling reaction system. The reaction is remarkably accelerated by adding an organic acid having a hydroxyl group or a salt thereof as an acid. Examples of these organic acids include glycolic acid, lactic acid, tartaric acid, malic acid, gluconic acid and salicylic acid, which are generally called oxyacids.

The water used as the component D is
There is no particular limitation, and water usually used for producing a hydrogel can be used. The amount of water used is preferably 20 to 80% by weight of the hydrogel patch base composition.

Gelation proceeds at room temperature within a few days, but the time can be shortened by heat treatment. A solvent and the like can be added to the composition for a water-containing gel patch base of the present invention, and the solvent includes alcohols, acetone, methyl ethyl ketone, ketones such as cyclohexanone, water such as cellosolve, dioxane, dimethylformamide, and N-methylpyrrolidone. In addition to the organic solvent which is miscible with, there are organic solvents which are immiscible with water, such as toluene, ethyl acetate, crotamiton and trichloroethylene, but not limited thereto. Among them, polyhydric alcohols are particularly preferably used, and examples of the polyhydric alcohols used include glycerin, polyglycerin, 1,3-butanediol, 1,4-butanediol, ethylene glycol, diethylene glycol, triethylene glycol and polyethylene glycol. , Propylene glycol, dipropylene glycol, polypropylene glycol, ethylene-propylene glycol copolymer and the like. These polyhydric alcohols may be used alone or in combination of two or more kinds without any problem. It is known that polyhydric alcohols enhance the transdermal absorbability of a medicinal component by increasing the solubility of the medicinal component in the skin and the moisturizing property of the skin. Further, in the case of a patch, it is essential that the drug is dissolved in the base, otherwise the drug could not move in the gel and could not reach the skin. However, many drugs that can be appropriately absorbed from the skin are lipophilic, and with a base such as a current poultice, the drug is not dissolved in the base and transdermal absorption of the drug cannot be expected. On the other hand, polyhydric alcohols are known as cosolvents that increase the solubility of drugs. For example, dimenhydrinate is well soluble in 50% propylene glycol. That is, by maintaining the polyhydric alcohol in a high concentration in the base, the solubility of the drug in the base can be increased and the transdermal absorbability can be improved. By blending the N-vinylacetamide homopolymer, the solvent such as polyhydric alcohol can be blended at a high concentration.

The gel body obtained by the present invention has a simple composition, a high solvent retention ability, and can be prepared at an extremely low cost. The base for a hydrogel patch of the present invention can be produced, for example, as follows. First, a polyacrylic acid monovalent salt and / or a copolymer of acrylic acid monovalent salt and acrylic acid is added to a solvent such as the polyhydric alcohol and sufficiently dispersed. Then, a water-soluble aluminum salt is dispersed in the above dispersion liquid. Next, a polyacrylic acid monovalent salt and / or a copolymer of acrylic acid monovalent salt and acrylic acid obtained as described above, an aluminum salt,
The mixed solution of polyhydric alcohol is gradually added to the mixed solution of water, N-vinylacetamide homopolymer and, if necessary, organic acid. After being added to water or the like in this way, it is heated or cooled if necessary, and mixed under shear stress for 30 minutes or more. The mixing under the shear stress can be carried out by appropriately selecting and using, for example, a kneader, a co-kneader, a kneader ruder, an ajihomomixer, a planetary mixer, a biaxial kneader or the like. In this case, lowering the temperature of the solution during mixing after the addition of water or the like causes discoloration of the base of the hydrogel patch obtained by mixing at high temperature for a long time, or the crosslinking reaction of aluminum may occur. This is because the gelation progresses during the kneading too much and the viscosity remarkably increases during the kneading, so that the molding process after the kneading becomes difficult, or the additive components may be deteriorated or decomposed, so that these are avoided. It should be noted that additives such as drugs may be added at any stage in the above manufacturing process. For example, when the additive is hydrophilic, it is added at the same time when water is added, and when it is lipophilic, it is dissolved in a polyhydric alcohol or the like in advance and then added together with the polyhydric alcohol, or the above solution is added. The addition at the time of addition of water together with the surfactant also gives good results.

The hydrogel adhesive patch base of the present invention is formed into a sheet by using a device capable of imparting shear stress, such as a single-screw extruder or a twin-screw extruder, and continuously attaching a die to the discharge port. It is carried out by extrusion molding or the like. As a result, the water-containing gel patch base of the present invention is obtained. This base is usually commercialized by bonding it to a support. Examples of the support include paper, wood, metal, glass fiber, cloth (nell, woven cloth, non-woven cloth, etc.), synthetic resin (polyurethane, ethylene vinyl acetate copolymer, polyvinyl chloride, polyester (eg polyethylene terephthalate), polyolefin ( For example, polyethylene, polypropylene, etc.), polyamide (for example, nylon 6, nylon 66, etc.), polyvinylidene chloride, polytetrafluoroethylene, etc.),
Examples include metal foils such as aluminum, rubber or cellulose derivatives, and molded products such as laminated films of these and plastic films, sheets (foil), tapes, and the like.

Further, other polymers can be added to the composition for a water-containing gel patch base of the present invention. These are components A to D, or (co) polymers derived from them. Those that are sufficiently compatible or compatible with each other so as to be cloudy are preferable. Examples of these polymers include gum arabic, tragacanth gum, locust bean gum, guar gum, echo gum, karaya gum, agar, starch,
Carrageenan, alginic acid, alginates (eg sodium alginate), propylene glycol alginate,
Dextran, dextrin, amylose, gelatin,
Collagen, pullulan, pectin, amylopectin, starch, amylopectin sodium semiglycolate,
Natural polymers such as chitin, albumin and casein, polyglutamic acid, polyaspartic acid, methyl cellulose, ethyl cellulose, propyl cellulose, ethyl methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl starch, alkali metal carboxymethyl cellulose, Alkali metal cellulose sulfate, cellulose graft polymer, cross-linked gelatin, cellulose acetate phthalate, starch-acrylic acid graft polymerization, phthalic anhydride modified gelatin, succinic acid modified gelatin and other semi-synthetic polymers, polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl Methyl ether, carboxy vinyl polymer, vinyl pyrrolidone-ethyl acrylate copolymer , Vinylpyrrolidone-styrene copolymer, vinylpyrrolidone-vinyl acetate copolymer, vinyl acetate- (meth) acrylic acid copolymer, polyvinyl acetate-crotonic acid copolymer, N-vinylacetamide-sodium acrylate copolymer Like N-
Vinylacetamide-based copolymer, polyvinylsulfonic acid, N-vinylacetamide crosslinked product, polyitaconic acid,
There are synthetic polymers such as polyhydroxyethyl acrylate, polyacrylamide, styrene-maleic anhydride copolymer, and acrylamide-acrylic acid copolymer, but not limited to these. Similarly, tackifying substances can be added, and examples thereof include, but are not limited to, silicone rubber, polyisobrengon, styrene-block copolymer rubber, acrylic rubber, natural rubber, and other tackifying substances. There are many drugs that can be administered using the hydrogel patch base of the present invention, for example, salicylic acid, glycol salicylate, methyl salicylate,
1-menthol, camphor, sulindac, trimethine sodium, naproxen, fenbufen, piroxicam, triamcinolone, hydrocortisone acetate, indomethacin, ketoprofen, acetaminophen,
Mefenamic acid, flufenamic acid, ibufenac, loxoprofen, thiaprofen, pranoprofen, fempfen, diclofenac, diclofenac sodium, alclofenac, oxyphenbutazone,
In addition to anti-inflammatory analgesics such as ibuprofen, felpinac, ketronac, vermoprofen, napumetone, naproxen, flurbiprofen, fluocinonide, clobetasol propionate, corticosteroids, antifungal agents, antihistamines, hypnotics, tranquilizers Agents, antihypertensive agents, antihypertensive diuretics, antibiotics, anesthetics, antibacterial agents,
Vitamins, antiepileptics, coronary vasodilators, antihistamines, antitussives, sex hormones, antidepressants, angina remedies,
In addition to narcotic analgesics and crude drugs, 5-fluorouracil,
Dihydroergotamine, fentanyl, desmopressin, digoxin, metoclopramide, domperide, scopolamine, scopolamine hydrobromide, veterinary medicine, hypnotics, cardiovascular therapeutics, brain metabolism stimulants, fungicides, enzyme preparations, enzyme inhibitors, organisms Pharmaceuticals (polypeptides), keratoses therapeutic agents, narcotics, antineoplastic agents, general anesthetics, anxiolytics, asthma / nasal allergy agents, antiparkinson agents, chemotherapeutic agents,
Antiparasitic agent, antiprotozoal agent, gout treatment agent, hemostatic agent, cardiotonic agent, stimulant / stimulant agent, addictive drug, Chinese herbal medicine, radiopharmaceutical,
Urogenital and anal agents, hypoglycemic agents, anti-ulcer agents, hair agents, sequestering agents, red foaming agents, antiperspirants,
Examples thereof include tranquilizers, anti-pseudo-blood agents, anti-rheumatic agents, anti-gout agents, anti-coagulants, etc., but are not limited to these, and two or more of these drugs can be used in combination as necessary. .

In the composition for a water-containing gel patch base of the present invention, in order to exert its properties more, or to improve the processability / moldability and quality, and to improve the dispersibility and stability of the drug in the gel body. For the purpose such as the above, a product selected according to the purpose can be further optionally blended so long as the performance of the base for a hydrogel patch is not impaired. These include, for example, wetting agents, surfactants, fragrances, UV screening agents, antiseptic bactericides, stabilizers, fillers, usability improvers, preservatives, plasticizers, antiaging agents, softening agents, pH adjusting agents, and deterioration. There are preventive agents. These additives are arbitrarily added within a range that does not affect the properties of the obtained gel body.

[0017]

EXAMPLES The usefulness of the present invention is described below with reference to examples, but the present invention is not limited thereto. Solubility of (Co) Polymer in Solvent 5 g of the polymer or copolymer was added to various solvents in an amount of 5%, stirred with a stirrer for 1 hour, and heated at 50 ° C. for 24 hours to observe the appearance. did.

[0018]

[Table 1] ◯: Completely dissolved, Δ: Almost dissolved, X: Undissolved: N-vinylacetamide homocopolymer: Sodium polyacrylate

Example 1 (Compound) N-vinylacetamide homopolymer 2 parts Sodium acrylate / acrylic acid = 60/40 (wt ratio) 4 parts Polyethylene glycol # 400 25 parts Lactic acid 0.5 parts Aluminum hydroxide gel 0. 5 parts Water 67 parts Titanium oxide 0.5 parts Indomethacin 0.5 parts (formulation) N-vinylacetamide homopolymer is dissolved in an aqueous lactic acid solution, and a copolymer of sodium acrylate and acrylic acid and hydroxylation are carried out therein. Knead while gradually adding a polyethylene glycol # 400 dispersion liquid of aluminum gel, titanium oxide and indomethacin. The obtained sol was coated on polypropylene release paper with a knife coater with a clearance of 0.5 mm, and then a non-woven fabric was stuck on the sol, put in an aluminum laminate bag, heat-sealed, and aged for 5 days to give a patch. Obtained.

Example 2 (Compounding) N-vinylacetamide homopolymer 4 parts Sodium polyacrylate 5 parts Glycerin 20 parts Ethanol 25 parts Aluminum glycinal 0.3 parts Tartaric acid 0.3 parts Flurbiprofen 0.6 parts Purified water 49 parts (formulation) A solution of sodium polyacrylate, aluminum glycinal and flurbiprofen dispersed in ethanol is gradually added to a mixed solution of glycerin, tartaric acid, N-vinylacetamide homopolymer and purified water. Knead while doing. The obtained sol was used in Test Example 2.

Example 3 (formulation) N-vinylacetamide homopolymer 5 parts Sodium acrylate / acrylic acid = 50/50 (wt ratio) 3 parts Glycerin 20 parts Propylene glycol 25 parts Aluminum glycinal 0.5 parts Tartaric acid 0 .5 parts ketoprofen 0.6 parts purified water 49 parts (formulation) A solution prepared by dispersing a copolymer of sodium acrylate and acrylic acid, aluminum glycinal and ketoprofen in propylene glycol is glycerin, tartaric acid and N-vinylacetamide. The mixture is kneaded while gradually adding it to the mixed solution of the homopolymer and water. The obtained sol was coated on a polypropylene-made release paper with a knife coater to prepare a sol.
Coating was carried out with a clearance of 5 mm, and then a non-woven fabric was stuck on the sol, put in an aluminum laminate bag, heat-sealed, and aged for 5 days to obtain a patch.

Comparative Example 1 (Compounding) Sodium polyacrylate 2 parts Polyacrylic acid 4 parts Polyethylene glycol # 400 25 parts Lactic acid 0.5 parts Aluminum hydroxide gel 0.5 parts Water 67 parts Titanium oxide 0.5 parts Indomethacin 0. 5 parts (prescription) Sodium polyacrylate, polyacrylic acid, aluminum hydroxide gel and titanium oxide, and polyethylene glycol # 40 of indomethacin in an aqueous lactic acid solution.
Knead while gradually adding 0 dispersion liquid. 0.5 g of the obtained sol on a polypropylene release paper with a knife coater.
After coating with a clearance of mm, a non-woven fabric was attached to the sol, placed in an aluminum laminate bag, heat-sealed, and aged for 5 days to obtain a patch.

Comparative Example 2 (Compounding) N-vinylacetamide homopolymer 0.5 part Sodium polyacrylate 5 parts Glycerin 20 parts Ethanol 25 parts Aluminum glycinal 0.005 parts Tartaric acid 0.005 parts Flurbiprofen 0. 6 parts Purified water 49 parts (Formulation) A solution prepared by dispersing a copolymer of sodium acrylate and acrylic acid, aluminum glycinal and flurbiprofen in ethanol is added to glycerin, tartaric acid, N-vinylacetamide homopolymer and Knead while gradually adding to a mixture of purified water. The obtained sol was used in Test Example 2.

Comparative Example 3 (Compounding) Ammonium polyacrylate 5 parts Glycerin 5 parts Ethanol 25 parts Aluminum glycinal 0.5 parts Tartaric acid 0.5 parts Ketoprofen 0.6 parts Purified water 49 parts (Prescription) Ammonium polyacrylate A solution in which aluminum glycinal and ketoprofen are dispersed in ethanol is gradually added to a mixed solution of glycerin, tartaric acid and purified water and kneaded. The obtained sol was coated on polypropylene release paper with a knife coater with a clearance of 0.5 mm, and then a non-woven fabric was stuck on the sol.
It was placed in an aluminum laminate bag, heat-sealed and aged for 5 days to obtain a patch.

Test Example 1: Severe test of gel body After heating the patches of Example 1 and Comparative Example 1 at 40 ° C for 7 days, the release paper was peeled off and the appearance of the gel inside was observed.
Items to be observed were shape retention of gel, dripping of gel, wetting agent and oozing of water from gel.

[0026]

[Table 2] Test Example 2: Measurement of gel strength The sol obtained in Example 2 and Comparative Example 2 was placed in a glass sample bottle SV-50 (Nichiden Rika Glass Co., Ltd.), capped and left at 20 ° C. Sensitive to the strength of the gel axis (aluminum cylinder, diameter 10mm, height 12mm) travel distance 30m
It was measured as the maximum stress when entering the gel at m and a moving speed of 5 mm / sec. The measurement was performed at room temperature, and the number of measurements was five. The correlation between the sensory test for gel strength and the stress value is as follows. Approx. 10: Not cross-linked (paste pulls thread when touched with finger, no repulsion) Approx. 30: Very slightly cross-linked. (When the paste is touched with a finger, the thread pulls, but there is a little repulsion.) Approx. 50: A little crosslinked. (Extends considerably when you touch the paste with your finger. There is strong resilience.) Approx. 70: Crosslinked. (Stretches slightly when you touch the paste with your finger. It has a strong resilience.) Approx. 90: It is fairly crosslinked. (If you pull the paste with your fingers, it won't grow much.)

[0027]

[Table 3] Test Example 3: Transdermal absorbability of ketoprofen patch 180 g to 220 g of Wister rat was shaved on the back, and the patch of Example 3 and Comparative Example 3 was applied so that the dose was 50 mg / kg. The blood concentration was measured over time.

[0028]

[Table 4]

[0029]

INDUSTRIAL APPLICABILITY As described above, the composition and base for the hydrogel patch base of the present invention comprises N-vinylacetamide homopolymer, polyacrylic acid monovalent salt and / or acrylic acid monovalent salt. Since it contains a copolymer with acrylic acid, a water-soluble aluminum salt, and water, it has an excellent ability to retain a solvent in the gel that promotes the transdermal absorbability of the drug. Excel. Moreover, it is excellent in tackiness and adheres well to the skin, and the base for a hydrogel patch is highly safe because it does not use an epoxy-based crosslinking agent or a urethane-based crosslinking agent.

Claims (4)

[Claims] 1. (A) N-vinylacetamide homopolymer, (B) polyacrylic acid monovalent salt and / or copolymer of acrylic acid monovalent salt and acrylic acid, (C) water-soluble aluminum salt, (D) A water-based gel patch base composition, which contains water as an essential component. 2. The content of component A is 0.1 to 30% by weight.
The composition for a water-containing gel patch base according to claim 1, which is set to. 3. The composition for a water-containing gel patch base according to claim 1, wherein the content of the C component is set to 0.005 to 1.0% by weight as aluminum. 4. A hydrous gel patch base, which is derived from the composition for a hydrogel patch base according to claim 1.