JP4592326B2 - Patch - Google Patents

Description

  The present invention relates to a patch.

In addition to being used for external preparations as pharmaceuticals, packs as cosmetics and quasi-drugs, etc., patches are widely used up to adhesive bandages. Patches can be broadly classified into those containing moisture in the adhesive base (such as a poultice) and those not containing (such as a plaster). As a patch containing water in the adhesive base, it contains gelatin-based poultice, polyacrylic acid and polyacrylate, and further contains carboxymethylcellulose and / or alkali metal alginate. A non-gelatin poultice (Patent Document 1) is known.
JP 59-110617 A JP-A-6-135828 JP-A-9-143060 JP-A-9-208462

  However, although a patch containing moisture in the adhesive base has higher moisturizing properties and superior usability compared to a patch that does not contain moisture in the adhesive base (so-called non-aqueous patch), There was a problem that the adhesive strength was weak and it was easily peeled off from the skin during use. Accordingly, an object of the present invention is to provide a patch having excellent usability and sufficient adhesive strength.

  As a result of intensive studies to achieve the above object, the present inventors have found that a patch having excellent adhesive strength can be obtained by adding β-glucan to the adhesive base, and the present invention has been completed. It came to do.

  That is, the present invention is a patch comprising a support and an adhesive layer disposed on at least one surface of the support, wherein the adhesive layer includes an adhesive base containing β-glucan. Provided is a patch characterized by being formed. Here, from the viewpoint of obtaining excellent adhesiveness, β-glucan is preferably β-1,3-glucan, and more preferably curdlan. The excellent adhesiveness of β-glucan is exhibited not only in a patch containing moisture in an adhesive base such as a patch, but also in a patch containing no moisture in an adhesive base such as a plaster.

  In addition, by including β-glucan in the adhesive base, not only the adhesiveness is improved, but the adhesive base can be softened. When the adhesive base becomes soft, the patch becomes easy to adhere to the skin, and there is an advantage that it is difficult to peel off even when it is applied near a joint where movement is intense. Furthermore, when the fragrance | flavor is contained in the adhesive base, (beta) -glucan also has the effect | action of strengthening the fragrance of a fragrance | flavor.

  In the present invention, the adhesive base may be one or more water-soluble substances selected from the group consisting of natural polymers, cellulose polymers and salts thereof, acrylic polymers and salts thereof, and vinyl polymers and salts thereof. Provided is the patch, which further contains a polymer. When the adhesive base contains such a water-soluble polymer, the adhesiveness can be made better.

  In the present invention, the adhesive base is composed of polyacrylic acid and a salt thereof, polyvinyl alcohol, polyvinylpyrrolidone, poly-N-methylvinylacetamide, carboxymethylcellulose and a salt thereof, hydroxyethylcellulose, and hydroxypropylcellulose. The patch further comprises at least one water-soluble polymer selected from the group consisting of: When the adhesive base contains such a water-soluble polymer, the adhesiveness can be made better.

  The present invention also includes 0.1 to 15% by mass of β-glucan, 0.1 to 40% by mass of polyacrylic acid and / or a salt thereof, based on the total mass of the adhesive base, The adhesive patch containing 20% by mass of polyvinyl alcohol is provided. A patch having such a composition is excellent in feeling of use and adhesiveness.

  The present invention also provides the patch, wherein the adhesive base further contains an acrylic adhesive and / or a block copolymer adhesive. By including β-glucan in the adhesive base of the plaster agent, it is possible to improve the adhesiveness of the plaster agent.

  The present invention further provides the patch, wherein the adhesive base contains a drug. By containing a drug (medicinal component) in the pressure-sensitive adhesive layer, it is possible to obtain a patch exhibiting a medicinal effect and excellent in feeling of use and adhesiveness.

  The adhesive patch of the present invention can exhibit sufficient adhesive strength when β-glucan is contained in the adhesive base.

  DESCRIPTION OF EMBODIMENTS Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings.

  FIG. 1 is a perspective view showing a preferred embodiment of the patch of the present invention. In FIG. 1, a patch 1 includes a support 2, a pressure-sensitive adhesive layer 3 disposed on the support 2, and a release sheet 4 attached on the pressure-sensitive adhesive layer 3.

  The pressure-sensitive adhesive layer 3 provided in the patch 1 of the present embodiment is formed from a pressure-sensitive adhesive base containing β-glucan. By blending β-glucan in the adhesive base, the adhesive strength of the obtained patch increases, and it becomes possible to solve the problem that the adhesive peels off during use.

  As β-glucan, there are β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, etc., from the viewpoint of obtaining a patch having sufficient adhesive force, β-1,3-glucan is preferred, with curdlan being most preferred. Moreover, from the viewpoint of exerting appropriate adhesive strength, the content of β-glucan is preferably 0.1 to 15% by mass, based on the total mass of the adhesive base, and 0.1 to 5% by mass. It is more preferable that

  The adhesive base used in the present embodiment may be any one of a sticking adhesive base and a plaster adhesive base. First, the adhesive base of the poultice will be described.

  The adhesive base of the poultice contains water in addition to β-glucan, and comprises a natural polymer, a cellulose polymer and a salt thereof, an acrylic polymer and a salt thereof, and a vinyl polymer and a salt thereof. It further contains one or more water-soluble polymers selected from the group.

  Specific examples of the water-soluble polymer are as follows. Examples of natural polymers include agarose, sodium alginate, gum arabic, carrageenan, gua gum, locust bean gum, pectin, tragacanth, starch, pullulan, xanthan gum, dextrin, gelatin, and casein. Examples of the cellulose polymer include ethyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose, nitrocellulose, and cationized cellulose. Examples of the acrylic polymer include polyacrylic acid, sodium polyacrylate, carboxyvinyl polymer, polyacrylamide, and polyacrylamide / acrylate copolymer. Examples of the vinyl polymer include polyvinyl pyrrolidone, polyvinyl alcohol, vinyl pyrrolidone, and polyvinyl pyrrolidone / vinyl alcohol copolymer. In addition, polyethylene oxide, polyvinyl ether, methoxyethylene maleic anhydride copolymer, isobutylene maleic anhydride copolymer, N-vinylacetamide, N-vinylacetamide and acrylic acid and / or acrylate copolymer, and the like are also included. .

  Among these, from the viewpoint of enhancing the adhesive strength of β-glucan, the water-soluble polymer contained in the adhesive base of the poultice is polyacrylic acid and a salt thereof, polyvinyl alcohol, polyvinyl pyrrolidone, poly-N-methyl. One or more water-soluble polymers selected from the group consisting of vinylacetamide, carboxymethylcellulose and salts thereof, hydroxyethylcellulose, and hydroxypropylcellulose are preferred.

  In particular, the adhesive base of the poultice is based on the total mass of the adhesive base, 0.1 to 15% by mass of β-glucan, 0.1 to 40% by mass of polyacrylic acid and / or a salt thereof, It is preferable to contain 0.1-20 mass% polyvinyl alcohol. The adhesive base having such a composition can enhance the adhesive strength of β-glucan, and can provide a patch having excellent use feeling and sufficient adhesive strength.

  The adhesive base of the poultice may contain a drug in addition to the above components. By blending a drug (medicinal component) with the adhesive base, it is possible to obtain a patch exhibiting medicinal effects and having excellent usability and adhesiveness. The drug to be blended in the adhesive base is not particularly limited as long as it has a pharmaceutical effect. For example, anti-inflammatory analgesics (indomethacin, ketoprofen, flurbiprofen, felbinac, ketorolac, diclofenac sodium, etc.), antiemetics (Granisetron hydrochloride, azasetron hydrochloride, ondansetron hydrochloride, ramosetron hydrochloride, etc.), hormonal agents (estradiol, estrone, estriol, echirin, echilenin, progesterone, hydroxyprogesterone caproate, medroxyprogesterone acetate, didrogesterone acetate, chlormadinone acetate, ethisterone, Dimethisterone, norethisterone, norethisterone acetate, norethisterone enanthate, ethinodiol acetate, megestrol acetate, allylestrenol, etc.), frequent urination Agents (oxybutynin hydrochloride, etc.), Ca antagonists (nifedipine, nisoldipine, nicardipine, nitredipine, etc.), corticosteroids (hydrocortisone, prednisolone, clobetasol propionate, etc.), hypnotic sedatives (phenobarbital, triazolam, nitrazepam, lorazepam, etc.) Tranquilizers (fluphenazine, diazepam, chlorpromazine, etc.), antihypertensive agents (clonidine, clonidine hydrochloride, pindolol, propranolol, nitrendipine, metoprolol, etc.), antihypertensive diuretics (hydrothiazide, etc.), antibiotics (penicillin, tetracycline, erythromycin) , Chloramphenicol), anesthetics (lidocaine, dibucaine hydrochloride, ethyl aminobenzoate, etc.), antibacterial substances (benzalkonium hydrochloride, clotrimazo) ), Vitamins (such as vitamin A), antiepileptics (such as nitrazepam), coronary vasodilators (such as nitroglycerin and isosorbide nitrate), antihistamines (such as diphenhydramine and chlorpheniramine), antitussives (tulobuterol hydrochloride, salbutamol, Ketotifen fumarate, tranilast, isoproterenol hydrochloride, etc.), antidepressants (clomipramine hydrochloride, amitriptyline hydrochloride, etc.), cerebral circulation improvers (dihydroergotoxine mesylate, ifenprodil, etc.), antitumor agents (5-fluorouracil, etc.), muscle Relaxants (eperisone, dantrolene, etc.), analgesics (fentanyl, morphine, etc.), polypeptide hormones (luteinizing hormone releasing hormone (LH-RH), thyroid stimulating hormone releasing hormone (TRH), etc.), peripheral vasodilation Agent, immunity Regulators (polysaccharides, auranofin, lobanzarit, etc.), biliary (ursodesoxycholic acid, etc.), diuretics (hydroflumethiazide, etc.), diabetics (tolbutamide, etc.), gout treatments (colchicine, etc.) ), Anti-Parkinson agents (amantadine, levodopa, etc.), anti-vertigo agents (difenidol, betahistine, etc.) and the like can be used.

  Usually, it is preferable to add 0.1 to 10% by mass of the drug based on the total mass of the adhesive base, although it varies depending on the compounding purpose. In addition, these drugs can be blended with two or more kinds of drugs as required when there is no inconvenience due to interaction.

  In addition, when the patch of the present invention is used as a cosmetic application, a compound and / or composition such as a skin-beautifying component or a moisturizing component having a whitening effect may be added to the adhesive base. Examples of skin-beautifying ingredients include aloe extract, age extract, orange extract, raspberry extract, kiwi extract, mulberry extract, cucumber extract, gardenia extract, chamomile extract, hawthorn extract, Atlantic rat extract, tiso extract, duke extract, tomato extract, loofah extract , Succinyl kefiran, maleil kefiran, malt root extract, rose extract, collagen, ceramide, squalane, hyaluronic acid, allantoin, marronnier extract, water-soluble placenta extract, vitamins, kojic acid and the like. Moreover, as a moisturizing component, acylated kefiran aqueous solution, malt extract, urea, glycols etc. are mentioned, for example.

  Furthermore, the adhesive base of the poultice agent may contain an antioxidant, a crosslinking agent, an antiseptic, a tackifier, a solubilizer, a dye, a fragrance, an ultraviolet absorber, an inorganic filler, a pH adjuster, etc. It can mix | blend with an adhesive layer. As these components, substances usually used in patches can be used. Specific examples are as follows.

  Examples of antioxidants include ascorbic acid, propyl gallate, butylhydroxyanisole, dibutylhydroxytoluene, nordihydroguaiaretic acid, tocopherol, tocopherol acetate, natural vitamin E, sodium nitrite, and sodium hydrogen nitrite. Can be mentioned.

  Examples of the crosslinking agent include a water-insoluble aluminum compound, a polyfunctional epoxy compound, an amino resin, a phenol resin, an epoxy resin, an alkyd resin, and an unsaturated polyester thermosetting resin, an isocyanate compound, a blocked isocyanate compound, and an organic crosslinking. Inorganic crosslinking agents such as agents, metals or metal compounds. These can be used alone or in combination of two or more.

  Examples of the preservative include ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, sorbic acid, and dehydroacetic acid.

  Examples of tackifiers include casein, pullulan, dextran, sodium alginate, soluble starch, carboxy starch, dextrin, carboxymethyl cellulose, sodium carboxymethyl cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, polyvinyl alcohol, polyethylene oxide, polyacrylamide, polyacrylamide. Acrylic acid, polyvinylpyrrolidone, carboxyvinyl polymer, polyvinyl ether, polymaleic acid copolymer, methoxyethylene maleic anhydride copolymer, isobutylene maleic anhydride copolymer, polyethyleneimine, polyvinyl alcohol partially saponified product, hydroxypropylmethylcellulose, Examples include xanthan gum and N-vinylacetamide.

  Examples of the solubilizer include diethyl sebacate, N-methyl-2-pyrrolidone, methyl salicylate, glycol salicylate, triacetin, oleyl alcohol, benzyl alcohol, isopropyl myristate, diisopropyl adipate, crotamiton, mint oil, camellia oil, castor oil And oil and olive oil.

  Examples of pigments include Red No. 2 (Amaranth), Red No. 3 (Erythrosin), Red No. 102 (New Coxin), Red No. 104 (1) (Phloxine B), Red No. 105 (1) (Rose) Bengal), Red 106 (Acid Red), Yellow 4 (Tartrazine), Yellow 5 (Sunset Yellow FCF), Green 3 (Fast Green FCF), Blue 1 (Brilliant Blue FCF), Blue 2 ( Indigo carmine) and the like.

  Examples of fragrances include mint oil, cinnamon oil, clove oil, fennel oil, castor oil, turpentine oil, eucalyptus oil, orange oil, lavender oil, lemon oil, rose oil, lemongrass oil, rosemary, sage, etc. A plant extract etc. are mentioned.

  Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid ester, amyl paradimethylaminobenzoic acid, salicylic acid ester, menthyl anthranilate, umbelliferone, esculin, benzyl cinnamate, cinoxalate, guaiazulene, urocanic acid, 2 -(2-hydroxy-5-methylphenyl) benzotriazole, 4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone, dioxybenzone, octabenzone, dihydroxydimethoxybenzophenone, soribenzone, benzoresorcinol, octyldimethylparaaminobenzoate, ethylhexylpara Examples thereof include methoxycynamate and butylmethoxydibenzoylmethane.

  Examples of the inorganic filler include calcium carbonate, magnesium carbonate, silicate (eg, aluminum silicate, magnesium silicate, etc.), silicic acid, barium sulfate, calcium sulfate, calcium zincate, zinc oxide, titanium oxide, and the like. Can be mentioned.

  Examples of the pH adjuster include acetic acid, formic acid, lactic acid, tartaric acid, oxalic acid, benzoic acid, glycolic acid, malic acid, citric acid, hydrochloric acid, nitric acid, sulfuric acid, sodium hydroxide, calcium hydroxide, methylamine, ethylamine, Propylamine, dimethylamine, diethylamine, dipropylamine, trimethylamine, triethylamine, tripropylamine, monomethanolamine, monoethanolamine, monopropanolamine, dimethanolamine, diethanolamine, dipropanolamine, trimethanolamine, triethanolamine, Examples include tripropanolamine, citrate buffer, phosphate buffer, glycine buffer, acetate buffer, and other buffer solutions.

  While the adhesive base of the poultice has been described above, the adhesive base of the present invention may use a plaster adhesive base. The plaster adhesive base will be described below.

  The adhesive base of the plaster agent contains an adhesive, and may contain a tackifier and a softener as necessary. As an adhesive, it is excellent in adhesiveness and drug release, so an acrylic adhesive containing a polymer containing (meth) acrylic acid ester as a monomer unit, a styrene block containing a styrene block copolymer Examples thereof include an adhesive containing a copolymer adhesive or an acrylic adhesive and a styrene block copolymer adhesive.

  Examples of acrylic pressure-sensitive adhesives include (meth) acrylic acid such as (meth) acrylic acid, (meth) acrylic acid-2-ethylhexyl, methyl (meth) acrylate, butyl (meth) acrylate, and hydroxyethyl (meth) acrylate. Examples thereof include an adhesive obtained by polymerizing or copolymerizing at least one monomer at a monomer ratio that exhibits adhesiveness at the temperature at which the patch is used.

  Acrylic adhesive is a copolymer that combines a high Tg monomer (a monomer having a glass transition point higher than room temperature when homopolymerized) and a low Tg monomer (a monomer having a glass transition point below room temperature when homopolymerized). Is preferred. As the high Tg monomer, (meth) acrylic acid that is polar and contributes to high adhesion is suitable, and as the low Tg monomer, an alkyl group having 4 to 12 carbon atoms (preferably 4 to 8) (meth) Acrylic acid esters (wherein the hydrogen atom of the alkyl group may be substituted with a hydroxyl group) are preferred.

  Acrylic adhesives include: 2-ethylhexyl acrylate / vinyl acetate copolymer, 2-ethylhexyl acrylate / vinyl acetate / acrylic acid copolymer, 2-ethylhexyl acrylate / vinyl acetate / hydroxyethyl acrylate Preferred are copolymers, 2-ethylhexyl acrylate / vinyl acetate / hydroxyethyl acrylate / acrylic acid copolymer, 2-ethylhexyl acrylate / -2-ethylhexyl methacrylate / dodecyl methacrylate copolymer, etc. 2-ethylhexyl acrylate / vinyl acetate copolymer and 2-ethylhexyl acrylate / vinyl acetate / acrylic acid copolymer are preferable.

  Styrene block copolymers include styrene-isoprene-styrene block copolymer (SIS), styrene-butadiene-styrene block copolymer (SBS), styrene-ethylene-butylene-styrene block copolymer (SEBS) or styrene-ethylene-propylene-styrene. Examples thereof include block copolymers (SEPS), and styrene-isoprene-styrene block copolymers (SIS) are particularly preferable. A styrene block copolymer-based pressure-sensitive adhesive usually contains these styrene block copolymers and a tackifier described below as essential components.

  Any combination of the above can be used as an adhesive containing an acrylic adhesive and a block copolymer adhesive, but SIS and 2-ethylhexyl acrylate / vinyl acetate / acrylic acid copolymer are mixed. Particularly preferred is the adhesive.

  Examples of tackifiers include alicyclic saturated hydrocarbon resins, rosins or rosin derivatives (eg, rosin glycerin ester, hydrogenated rosin, hydrogenated rosin glycerin ester or rosin pentaerythritol ester), terpene resins, petroleum resins Or a maleic acid resin etc. are mentioned. Among these, alicyclic saturated hydrocarbon resins and glycerin esters of hydrogenated rosin are particularly preferable. These tackifiers may be used alone or in combination of two or more.

  Softeners include petroleum oils (eg paraffinic process oil, naphthenic process oil or aromatic process oil), squalane, squalene, vegetable oils (eg almond oil, olive oil, camellia oil, castor oil, tall oil) Or peanut oil, etc.), olefinic acid, silicone oil, dibasic acid ester (such as dibutyl phthalate or dioctyl phthalate), liquid rubber (such as polybutene or liquid isoprene rubber), liquid fatty acid ester (isopropyl myristate, hexyl laurate, Diethyl sebacate or isopropyl sebacate), diethylene glycol, polyethylene glycol, salicylate glycol, propylene glycol, dipropylene glycol, triacetin, triethyl citrate Tamiton, and the like. Among these, liquid paraffin and / or isopropyl myristate are preferable because they can impart appropriate adhesion to the skin. These softeners may be used alone or in combination of two or more.

  Furthermore, the adhesive base of the plaster agent may contain the aforementioned drug, skin beautifying component and moisturizing component. Moreover, the adhesive base of the plaster agent may contain an antioxidant, a crosslinking agent, an antiseptic, a solubilizer, a dye, a fragrance, an ultraviolet absorber, an inorganic filler, a pH adjuster, and the like as necessary. Good. Specific examples of these components are the same as the specific examples given for the adhesive base of the poultice.

  The pressure-sensitive adhesive layer 3 formed from the pressure-sensitive adhesive base containing the components described above is disposed on the support 2. The support 2 used in the patch 1 of the present embodiment is not particularly limited as long as it can support the pressure-sensitive adhesive layer 3, and a stretchable or non-stretchable support can be used.

  As such a support, specifically, synthetic fibers or natural fibers such as polyurethane, polyester, polypropylene, polyvinyl acetate, polyvinylidene chloride, polyethylene, polyethylene terephthalate, aluminum sheet, nylon, acrylic, cotton, rayon, acetate, Or the fiber sheet which combined these fibers into the woven fabric or the nonwoven fabric, Furthermore, the fiber sheet etc. which consist of a composite material with these and the film which has water vapor permeability are mentioned.

  Among these, from the viewpoint of safety, versatility, and stretchability, a woven or non-woven fiber sheet made of polyester, polyethylene and / or polyethylene terephthalate is preferable, and a woven or non-woven fiber sheet made of polyethylene terephthalate is more preferable. . Even if such a fiber sheet is thick, it has flexibility, is easy to follow the skin, and has low skin irritation. Furthermore, it is possible to obtain a patch having an appropriate self-supporting property by using such a fiber sheet.

  The patch 1 includes a release sheet 4 attached on the pressure-sensitive adhesive layer 3. Examples of such release sheet 4 include polyesters such as polyethylene terephthalate, films such as polyvinyl chloride and polyvinylidene chloride, and laminate films of fine paper and polyolefin. These release sheets are preferably subjected to silicone treatment on the surface in contact with the pressure-sensitive adhesive layer 3 because the workability when peeling the release sheet 4 from the patch 1 is enhanced.

  Next, the manufacturing method of the patch 1 of this embodiment is demonstrated. First, an adhesive base is prepared according to a conventional method. Next, the obtained adhesive base is applied on a support to form a coating film, and a release sheet is laminated on the coating film. This is stored at room temperature for several days and is sufficiently crosslinked to form an adhesive layer. After the pressure-sensitive adhesive layer is formed, the patch is obtained by cutting into a predetermined shape.

  As mentioned above, although preferred embodiment of the patch of this invention and the manufacturing method of the patch of this invention were demonstrated, this invention is not limited to the said embodiment.

  For example, the shape of the patch may be a circle or an ellipse. Moreover, you may give a hole, a cut | interruption, etc. Furthermore, it can be made into the shape designed suitably according to the site | part of the body where a patch is used. For example, it can be cut into the shape of a face so that it can be applied to the face, and the eyes, nose, mouth and chin can be cut into appropriate shapes.

  Moreover, in the manufacturing method of a patch, after apply | coating an adhesive base on a peeling sheet and forming an adhesive layer, you may bond a support body to an adhesive layer.

  The patch of the present invention can be used for pharmaceuticals or a similar patch, plaster, cooling sheet, cosmetic or similar pack.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in more detail, this invention is not limited to these Examples.

Example 1
1.5% curdlan, 3.5% polyacrylic acid, 2.5% sodium polyacrylate, 1.5% polyvinyl alcohol, 30.0% concentrated glycerin, 0.5% monostearin Polyethylene glycol acid, 0.5% synthetic aluminum silicate, 0.3% magnesium aluminate metasilicate, 1.0% titanium oxide, 0.35% sodium edetate, 0.3% tartaric acid, 1% Pap of 25% glycol salicylate, 0.1% l-menthol 0.3% dl-camphor, 1.0% tocopherol acetate, remaining amount of water (% represents mass%). The agent was prepared by a conventional method. The pH of the obtained cataplasm was 5.08.

(Comparative Example 1)
In the composition of the cataplasm of Example 1, a cataplasm having a composition using gelatin instead of curdlan was produced in the same manner as in Example 1. In addition, pH of the obtained cataplasm was 5.24.

(Test Example 1)
The adhesive force of the cataplasm of Example 1 and Comparative Example 1 was measured. The adhesive strength was measured according to the Nichiban Rolling Ball method ("Adhesion Handbook", Kobunshi Shuppankai, 14th edition, p. 381, 1985). That is, a 20/32 inch stainless steel ball was rolled on a poultice, and the adhesive strength was measured using the distance the ball rolled as an index of adhesive strength.

  The adhesive strength (mm) of the cataplasm of Comparative Example 1 was 40.2, whereas the adhesive of the cataplasm of Example 1 was 23.2, and the adhesive of the cataplasm of Example 1 It became clear that was stronger.

(Test Example 2)
Eight healthy persons were allowed to apply the patch of Example 1 and Comparative Example 1 on their elbows for 6 hours, and evaluated the adhesive strength, the softness of the plaster (adhesive base) and the strength of the scent. Evaluation was based on the numerical value of multiples, such as how many times the poultice of Example 1 is stronger, with the cataplasm of Comparative Example 1 as a reference. The evaluation results for each item are summarized in Table 1.

  As can be seen from the results shown in Table 1, regarding the adhesive strength, all the subjects evaluated that the cataplasm of Example 1 had better adhesive strength. Moreover, about the softness of the plaster and the strength of the fragrance, the same evaluation or evaluation that the cataplasm of Example 1 was superior was obtained. From the above results, it was confirmed that the patch of the present invention was excellent in use feeling and had sufficient adhesive strength.

It is a perspective view which shows suitable one Embodiment of the patch of this invention.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1 ... Patch, 2 ... Support body, 3 ... Adhesive layer, 4 ... Release sheet.

Claims (7)

A patch comprising a support and a pressure-sensitive adhesive layer disposed on at least one surface of the support, wherein the pressure-sensitive adhesive layer contains β-1,3-glucan and contains a starch degradation product A patch characterized by being formed from a non- adhesive base. The patch according to claim 1 , wherein the β-1,3-glucan is curdlan. The adhesive base further contains at least one water-soluble polymer selected from the group consisting of natural polymers, cellulose polymers and salts thereof, acrylic polymers and salts thereof, and vinyl polymers and salts thereof. The patch according to claim 1 or 2, wherein the patch is. The adhesive base is one or more selected from the group consisting of polyacrylic acid and salts thereof, polyvinyl alcohol, polyvinylpyrrolidone, poly-N-methylvinylacetamide, carboxymethylcellulose and salts thereof, hydroxyethylcellulose, and hydroxypropylcellulose. The patch according to claim 1 or 2, further comprising a water-soluble polymer. 0.1 to 15% by mass of β-1,3-glucan , 0.1 to 40% by mass of polyacrylic acid and / or a salt thereof, and 0.1 to 20% by mass based on the total mass of the adhesive base The patch according to claim 4 , comprising:% polyvinyl alcohol. The patch according to claim 1 or 2 , wherein the adhesive base further contains an acrylic adhesive and / or a block copolymer adhesive. The patch according to any one of claims 1 to 6 , wherein the adhesive base contains a drug.

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