CN108125931A - A kind of hydrogel is brought down a fever patch and its preparation process - Google Patents

A kind of hydrogel is brought down a fever patch and its preparation process Download PDF

Info

Publication number
CN108125931A
CN108125931A CN201711247369.2A CN201711247369A CN108125931A CN 108125931 A CN108125931 A CN 108125931A CN 201711247369 A CN201711247369 A CN 201711247369A CN 108125931 A CN108125931 A CN 108125931A
Authority
CN
China
Prior art keywords
parts
hydrogel
fever
patch
brought down
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711247369.2A
Other languages
Chinese (zh)
Inventor
蔡金山
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NANJING FANKANG MEDICAL TECHNOLOGY Co Ltd
Original Assignee
NANJING FANKANG MEDICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NANJING FANKANG MEDICAL TECHNOLOGY Co Ltd filed Critical NANJING FANKANG MEDICAL TECHNOLOGY Co Ltd
Priority to CN201711247369.2A priority Critical patent/CN108125931A/en
Publication of CN108125931A publication Critical patent/CN108125931A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention belongs to pharmaceutical technology fields, more particularly to a kind of hydrogel is brought down a fever patch and its preparation process, the present invention hydrogel bring down a fever patch with NP 700 for hydrophilic polymer, it is aided with gelatin polymer, gel time controlling agent, preservative, moisturizer, pH controlling agents, thickener and coolant agent again to be made, ingredient safety, speed of bringing down a fever is fast, has no irritating odor, there is light perfume (or spice), usage comfort is high；The nerol wherein added in is since unique molecular structure can be combined closely with macromolecular scaffold, and dispersed polymer at a certain temperature, improves the permeability of hydrogel, the hydrone after vaporization can quickly be spread, and have the function that cool down rapidly to the adsorption capacity of hydrone；In addition, the fresh scent of nerol can also promote the use feeling for patch of bringing down a fever；The present invention prepare hydrogel bring down a fever patch simple process and low cost it is honest and clean, manufacturing process is nontoxic and pollution-free.

Description

A kind of hydrogel is brought down a fever patch and its preparation process
Technical field
The invention belongs to pharmaceutical technology field, more particularly to a kind of hydrogel is brought down a fever patch and its preparation process.
Background technology
Hydrogel can be used for human body Physical temperature-lowering articles for use as a kind of high water-keeping material of high water absorption；By hydrogel patch For human body surface, in hydrogel, the vaporization of sufficient moisture, which is absorbed heat, takes away internal heat, so as to reduce human body temperature.The prior art In hydrogel patch speed of bringing down a fever of bringing down a fever it is slower, mainly due to hydrogel bring down a fever patch macromolecule solid water effect it is too strong, Transpirable hydrone is few, and gas permeability is bad, leads to that heat transfer speed is slow, and endothermic effect is not notable.
Peppermint can be also added in existing hydrogel patch as coolant agent, peppermint can generate cooling effect and pharmacological property not By force, the temperature sensor of human body can be acted, makes to give people cool feeling by cold sensor；But due to its strong smell And the intense irritation to skin, mucous membrane tissue and eye, therefore should not largely use.
Invention content
The present invention solves hydrogel in the prior art patch of bringing down a fever and brings down a fever the skill of slower, the irritant smell of speed Art problem.
To solve the above problems, technical scheme is as follows：
A kind of hydrogel is brought down a fever patch, includes the component of following parts by weight：
NP-700 (Sodium Polyacrylate Viscomate NP-700)：150 parts；
Glycerine：650-850 parts, as moisturizer；
Dihydroxyaluminium Aminoacetate：3-6 parts；
EDETATE DISODIUM：2-4 parts, as chelating agent；
PVPP (crosslinked polyvinylpyrrolidone)：20-40 parts；
CMC (carboxymethyl cellulose)：18-24 parts；
Pure water：1600-2000 parts；
PVP-K120 (polyvinylpyrrolidone K120)：160-180 parts, as tackifier；
Tartaric acid：6-10 parts；
Brilliant blue：0.006-0.009 parts, as colorant；
Ethyl alcohol：14-22 parts；
WS-23 (N, 2,3. trimethyl -2- butanamides)：3-9 parts, as coolant agent, have clear happy, lasting, new Fresh, nonirritant pungent, without the advantages such as bitter taste, dosage be low；
Borneol：3-9 parts, as coolant agent adjuvant；
DMDMH (1,3 dihydroxymethyl -5,5 Dimethyl Hydan)：6-12 parts；As preservative.
Preferably, the hydrogel patch of bringing down a fever of going back further includes the components of following parts by weight：
Nerol：3-6 parts, nerol chemical name is cis- 3,7- dimethyl -2,6- octadienol, is deposited in molecular structure In two-C=C- and-OH, can combine closely with macromolecular scaffold, and dispersed polymer changes the adsorption capacity of hydrone The permeability of kind hydrogel.
Preferably, the hydrogel patch of bringing down a fever of going back includes the components of following parts by weight：
NP-700：150 parts；
Glycerine：750 parts；
Dihydroxyaluminium Aminoacetate：4.5 part；
EDETATE DISODIUM：3 parts；
PVPP：30 parts；
CMC：21 parts；
Pure water：1800 parts；
PVP-K120：170 parts；
Tartaric acid：8 parts；
Brilliant blue：0.007 part；
Ethyl alcohol：18 parts；
WS-23：6 parts；
Borneol：6 parts；
DMDMH：9 parts；
Nerol：4.5 part.
A kind of hydrogel is brought down a fever the preparation process of patch, is included the following steps,
A. the ethanol water of configuration quality score 95% is spare, and configuration quality score is 10% aqueous tartaric acid solution, Configuration quality score is 0.1% brilliant blue aqueous solution, the DMDMH is dissolved in purified water remainder, DMDMH aqueous solutions are made；
B. the borneol, WS-23 are added in ethanol water described in step A, fully dissolved；
C. the NP-700, Dihydroxyaluminium Aminoacetate, EDETATE DISODIUM, PVPP, CMC, PVP-K120 are added in the glycerine, fully Dissolving；
D. aqueous tartaric acid solution, brilliant blue aqueous solution, DMDMH aqueous solutions described in step A are sequentially added and is mixed obtained by step C In solution, it is uniformly mixed；
E. mixed solution made from step B is added in mixed solution made from step D, after stirring evenly, ultrasonic 5-10 Minute, stand 12-36 hours under the conditions of 5-10 DEG C.
In step E, by stirring, ultrasound, cross-linked polymer is obtained, by stand at low temperature, obtains stable three-dimensional network Water
Gel.
Preferably, the hydrogel bring down a fever patch step of preparation process B in also to add in nerol.
Preferably, the hydrogel bring down a fever the step of preparation process E of patch mixing speed be 120-240 revs/min.
Preferably, the hydrogel bring down a fever patch step of preparation process E ultrasonic powers be 0.2-0.4W/cm2。
Relative to the prior art, advantages of the present invention is as follows,
The hydrogel of the present invention brings down a fever patch using NP-700 as hydrophilic polymer, then be aided with gelatin polymer, gel time Controlling agent, preservative, moisturizer, pH controlling agents, thickener and coolant agent are made, and ingredient safety, speed of bringing down a fever is fast, non-stimulated Property smell, have light perfume (or spice), usage comfort is high；The nerol wherein added in can be close with macromolecular scaffold due to unique molecular structure With reference to, and dispersed polymer at a certain temperature, improves the permeability of hydrogel, the water after vaporization to the adsorption capacity of hydrone Molecule can quickly be spread, and have the function that cool down rapidly；In addition, the fresh scent of nerol can also promote the use for patch of bringing down a fever Impression；The present invention prepare hydrogel bring down a fever patch simple process and low cost it is honest and clean, manufacturing process is nontoxic and pollution-free.
Specific embodiment
Embodiment 1：
A kind of hydrogel is brought down a fever patch, includes the component of following parts by weight：
NP-700：150 parts；
Glycerine：650 parts；
Dihydroxyaluminium Aminoacetate：3 parts；
EDETATE DISODIUM：2 parts；
PVPP：20 parts；
CMC：18 parts；
Pure water：1600 parts；
PVP-K120：160 parts；
Tartaric acid：6 parts；
Brilliant blue：0.006 part；
Ethyl alcohol：14 parts；
WS-23：3 parts；
Borneol：3 parts；
DMDMH：6 parts.
Embodiment 2：
NP-700：150 parts；
Glycerine：750 parts；
Dihydroxyaluminium Aminoacetate：4.5 part；
EDETATE DISODIUM：3 parts；
PVPP：30 parts；
CMC：21 parts；
Pure water：1800 parts；
PVP-K120：170 parts；
Tartaric acid：8 parts；
Brilliant blue：0.007 part；
Ethyl alcohol：18 parts；
WS-23：6 parts；
Borneol：6 parts；
DMDMH：9 parts.
Embodiment 3：
A kind of hydrogel is brought down a fever patch, includes the component of following parts by weight：
NP-700：150 parts；
Glycerine：850 parts；
Dihydroxyaluminium Aminoacetate：6 parts；
EDETATE DISODIUM：4 parts；
PVPP：40 parts；
CMC：24 parts；
Pure water：2000 parts；
PVP-K120：180 parts；
Tartaric acid：10 parts；
Brilliant blue：0.009 part；
Ethyl alcohol：22 parts；
WS-23：9 parts；
Borneol：9 parts；
DMDMH：12 parts.
Embodiment 4：
NP-700：150 parts；
Glycerine：750 parts；
Dihydroxyaluminium Aminoacetate：4.5 part；
EDETATE DISODIUM：3 parts；
PVPP：30 parts；
CMC：21 parts；
Pure water：1800 parts；
PVP-K120：170 parts；
Tartaric acid：8 parts；
Brilliant blue：0.007 part；
Ethyl alcohol：18 parts；
WS-23：6 parts；
Borneol：6 parts；
DMDMH：9 parts；
Nerol：4.5 part.
Embodiment 5：
The proportioning that embodiment 1-3 is respectively adopted prepares hydrogel and brings down a fever patch, includes the following steps,
A. the ethanol water of configuration quality score 95% is spare, and configuration quality score is 10% aqueous tartaric acid solution, Configuration quality score is 0.1% brilliant blue aqueous solution, the DMDMH is dissolved in purified water remainder, DMDMH aqueous solutions are made；
B. the borneol, WS-23 are added in ethanol water described in step A, fully dissolved；
C. the NP-700, Dihydroxyaluminium Aminoacetate, EDETATE DISODIUM, PVPP, CMC, PVP-K120 are added in the glycerine, fully Dissolving；
D. aqueous tartaric acid solution, brilliant blue aqueous solution, DMDMH aqueous solutions described in step A are sequentially added and is mixed obtained by step C In solution, it is uniformly mixed；
E. mixed solution made from step B is added in mixed solution made from step D, is stirred with 120 revs/min of speed It mixes, after stirring evenly, ultrasound 5 minutes, ultrasonic power 0.2W/cm2, 12 hours are stood under the conditions of 5-10 DEG C.
Embodiment 6：
The proportioning that embodiment 4 is respectively adopted prepares hydrogel and brings down a fever patch, includes the following steps,
A. the ethanol water of configuration quality score 95% is spare, and configuration quality score is 10% aqueous tartaric acid solution, Configuration quality score is 0.1% brilliant blue aqueous solution, the DMDMH is dissolved in purified water remainder, DMDMH aqueous solutions are made；
B. the borneol, WS-23, nerol are added in ethanol water described in step A, fully dissolved；
C. the NP-700, Dihydroxyaluminium Aminoacetate, EDETATE DISODIUM, PVPP, CMC, PVP-K120 are added in the glycerine, fully Dissolving；
D. aqueous tartaric acid solution, brilliant blue aqueous solution, DMDMH aqueous solutions described in step A are sequentially added and is mixed obtained by step C In solution, it is uniformly mixed；
E. mixed solution made from step B is added in mixed solution made from step D, is stirred with 240 revs/min of speed It mixes, after stirring evenly, ultrasound 10 minutes, ultrasonic power 0.4W/cm2, 36 hours are stood under the conditions of 5-10 DEG C.
Embodiment 7：
The hydrogel of embodiment 1-4 patch of bringing down a fever is made defervescence plaster used, is attached to patient's temple, for antipyretic treatment, In typical 100 leading case example, that brought down a fever in 2-3 hours accounts for 78%, and that brought down a fever in 3-4 hours accounts for 13%；Patient generally makes With impression：It has no irritating odor, have light fragrance.
It should be noted that above-described embodiment is only presently preferred embodiments of the present invention, there is no be used for limiting the present invention's Protection domain, the equivalent replacement or replacement made on the basis of the above all belong to the scope of protection of the present invention.

Claims (7)

  1. The patch 1. a kind of hydrogel is brought down a fever, which is characterized in that include the component of following parts by weight：
    NP-700：150 parts；
    Glycerine：650-850 parts；
    Dihydroxyaluminium Aminoacetate：3-6 parts；
    EDETATE DISODIUM：2-4 parts；
    PVPP：20-40 parts；
    CMC：18-24 parts；
    Pure water：1600-2000 parts；
    PVP-K120：160-180 parts；
    Tartaric acid：6-10 parts；
    Brilliant blue：0.006-0.009 parts；
    Ethyl alcohol：14-22 parts；
    WS-23：3-9 parts；
    Borneol：3-9 parts；
    DMDMH：6-12 parts.
  2. The patch 2. hydrogel as described in claim 1 is brought down a fever, which is characterized in that it is described go back hydrogel bring down a fever patch further include with The component of lower parts by weight：
    Nerol：3-6 parts.
  3. The patch 3. hydrogel as claimed in claim 2 is brought down a fever, which is characterized in that include the component of following parts by weight：
    NP-700：150 parts；
    Glycerine：750 parts；
    Dihydroxyaluminium Aminoacetate：4.5 part；
    EDETATE DISODIUM：3 parts；
    PVPP：30 parts；
    CMC：21 parts；
    Pure water：1800 parts；
    PVP-K120：170 parts；
    Tartaric acid：8 parts；
    Brilliant blue：0.007 part；
    Ethyl alcohol：18 parts；
    WS-23：6 parts；
    Borneol：6 parts；
    DMDMH：9 parts；
    Nerol：4.5 part.
  4. The preparation process of patch 4. the hydrogel as described in claim 1-3 is brought down a fever, which is characterized in that include the following steps,
    A. the ethanol water of configuration quality score 95% is spare, and configuration quality score is 10% aqueous tartaric acid solution, is configured Mass fraction is 0.1% brilliant blue aqueous solution, the DMDMH is dissolved in purified water remainder, DMDMH aqueous solutions are made；
    B. the borneol, WS-23 are added in ethanol water described in step A, fully dissolved；
    C. the NP-700, Dihydroxyaluminium Aminoacetate, EDETATE DISODIUM, PVPP, CMC, PVP-K120 are added in the glycerine, it is fully molten Solution；
    D. aqueous tartaric acid solution, brilliant blue aqueous solution, DMDMH aqueous solutions described in step A are sequentially added into mixed solution obtained by step C In, it is uniformly mixed；
    E. mixed solution made from step B is added in mixed solution made from step D, it is 5-10 minutes ultrasonic after stirring evenly, 12-36 hours are stood under the conditions of 5-10 DEG C.
  5. The preparation process of patch 5. hydrogel as claimed in claim 4 is brought down a fever, which is characterized in that also to be added in the step B Nerol.
  6. The preparation process of patch 6. hydrogel as claimed in claim 5 is brought down a fever, which is characterized in that the mixing speed of the step E It is 120-240 revs/min.
  7. The preparation process of patch 7. hydrogel as claimed in claim 5 is brought down a fever, which is characterized in that the step E ultrasonic powers are 0.2-0.4W/cm2。
CN201711247369.2A 2017-12-01 2017-12-01 A kind of hydrogel is brought down a fever patch and its preparation process Pending CN108125931A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711247369.2A CN108125931A (en) 2017-12-01 2017-12-01 A kind of hydrogel is brought down a fever patch and its preparation process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711247369.2A CN108125931A (en) 2017-12-01 2017-12-01 A kind of hydrogel is brought down a fever patch and its preparation process

Publications (1)

Publication Number Publication Date
CN108125931A true CN108125931A (en) 2018-06-08

Family

ID=62390015

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711247369.2A Pending CN108125931A (en) 2017-12-01 2017-12-01 A kind of hydrogel is brought down a fever patch and its preparation process

Country Status (1)

Country Link
CN (1) CN108125931A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108704162A (en) * 2018-08-08 2018-10-26 中国科学院长春应用化学研究所 A kind of water suction dressing and preparation method thereof
CN109091290A (en) * 2018-08-08 2018-12-28 中国科学院长春应用化学研究所 It is a kind of persistently effectively defervescence plaster used and preparation method thereof
CN109512802A (en) * 2018-12-13 2019-03-26 广州润虹医药科技股份有限公司 It is a kind of defervescence plaster used and preparation method thereof
CN110693813A (en) * 2019-09-30 2020-01-17 杭州金花医药生物科技有限公司 Hydrogel for defervescence and preservative-free defervescence patch containing hydrogel
CN111437432A (en) * 2020-04-17 2020-07-24 常州美洛医疗科技有限公司 Preparation method of graphene physical antibacterial hydrogel dressing
CN112107413A (en) * 2020-09-24 2020-12-22 江苏江南烯元石墨烯科技有限公司 Preparation method of graphene medical antipyretic patch
CN115350165A (en) * 2022-08-19 2022-11-18 海南涛生医药科技研究院有限公司 Gel for medical antipyretic patch and preparation method of medical antipyretic patch

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013164426A3 (en) * 2012-05-02 2014-01-30 Attratec Gmbh Attractant composition
CN105919981A (en) * 2016-06-28 2016-09-07 江苏迪沃生物制品有限公司 Defervescence patch and preparation process thereof
CN107286020A (en) * 2017-06-27 2017-10-24 华北理工大学 Nerol fatty acid ester analog derivative and its application and preparation method
CN107362155A (en) * 2017-08-31 2017-11-21 苏州幼儿师范高等专科学校 It is a kind of defervescence plaster used

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013164426A3 (en) * 2012-05-02 2014-01-30 Attratec Gmbh Attractant composition
CN105919981A (en) * 2016-06-28 2016-09-07 江苏迪沃生物制品有限公司 Defervescence patch and preparation process thereof
CN107286020A (en) * 2017-06-27 2017-10-24 华北理工大学 Nerol fatty acid ester analog derivative and its application and preparation method
CN107362155A (en) * 2017-08-31 2017-11-21 苏州幼儿师范高等专科学校 It is a kind of defervescence plaster used

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108704162A (en) * 2018-08-08 2018-10-26 中国科学院长春应用化学研究所 A kind of water suction dressing and preparation method thereof
CN109091290A (en) * 2018-08-08 2018-12-28 中国科学院长春应用化学研究所 It is a kind of persistently effectively defervescence plaster used and preparation method thereof
CN109091290B (en) * 2018-08-08 2020-06-26 中国科学院长春应用化学研究所 Lasting and effective antipyretic patch and preparation method thereof
CN109512802A (en) * 2018-12-13 2019-03-26 广州润虹医药科技股份有限公司 It is a kind of defervescence plaster used and preparation method thereof
CN110693813A (en) * 2019-09-30 2020-01-17 杭州金花医药生物科技有限公司 Hydrogel for defervescence and preservative-free defervescence patch containing hydrogel
CN111437432A (en) * 2020-04-17 2020-07-24 常州美洛医疗科技有限公司 Preparation method of graphene physical antibacterial hydrogel dressing
CN112107413A (en) * 2020-09-24 2020-12-22 江苏江南烯元石墨烯科技有限公司 Preparation method of graphene medical antipyretic patch
CN115350165A (en) * 2022-08-19 2022-11-18 海南涛生医药科技研究院有限公司 Gel for medical antipyretic patch and preparation method of medical antipyretic patch

Similar Documents

Publication Publication Date Title
CN108125931A (en) A kind of hydrogel is brought down a fever patch and its preparation process
CN102078284B (en) Gatifloxacin-containing gel for eyes and preparation method thereof
CN113952460B (en) Compound external preparation for treating alopecia areata and preparation method thereof
AU2003233304B2 (en) Film-shaped, dissolvable preparations for active substance release and method for the production thereof
JP3553174B2 (en) Sheet pack
CN1407898A (en) Novel topical oestroprogestational compositions with systemic effect
JPS63174924A (en) Ointment base and ointment
JPH0739748A (en) Low temperature crosslinked type gel agent
JP3908275B2 (en) Cold seat
JP2002020274A (en) Non-steroidal anti-inflammatory analgesic transdermal patch agent for outer application and transdermal patch for outer application
JPH078779B2 (en) Effervescent cosmetics
JP4677063B2 (en) Dutch mustard extract combination external preparation
JP2004307491A (en) Skin care preparation for external use containing heparinoid
CN108403622A (en) A kind of hydrogel and the technique using hydrogel making temperature-reducing paste
JP2008024651A (en) Method for suppressing color development of catechin
WO2003002075A1 (en) Sheet-type packs
WO2001087244A1 (en) Sheet-type packs
WO2000044336A1 (en) Sheet-type packs
JP2003128557A (en) Glucosamine-containing cataplasm
JPH01151524A (en) 'satotsu-ko' poultice and preparation thereof
CN106560175A (en) Menthol-camphor eutectic mixture nano-emulsion in situ gel preparation
JPH03109326A (en) Fleroxacin eye drop
CN107625920A (en) Gynaecology's gel and preparation method thereof
KR101080444B1 (en) Manufacturing method of water-soluble gel having cooling effect
JP2003095924A (en) Heat gelling artificial lacrima

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180608

RJ01 Rejection of invention patent application after publication