CN109091290B - Lasting and effective antipyretic patch and preparation method thereof - Google Patents

Abstract

The invention provides a lasting and effective antipyretic patch and a preparation method thereof, belonging to the field of polymer hydrogel and a preparation method thereof. The problem of current subsides of bringing down a fever water content low radiating effect is poor is solved. The subsides of bringing down a fever, from the bottom up includes impressed watermark rete, hydrogel layer and non-woven fabrics layer in proper order, hydrogel layer, count according to parts by weight, including following raw materials: 3-7 parts of sodium polyacrylate, 15-25 parts of glycerol, 0.1-0.35 part of cross-linking agent, 0.05-0.25 part of cross-linking regulator, 0.05-0.25 part of forming agent, 0-2 parts of forming regulator, 0.05-2 parts of dispersing agent, 0.05-2 parts of traditional Chinese medicine extracting solution, 0-2 parts of borneol, 0.05-2 parts of alcohol, 0.05-2 parts of bacteriostatic agent and 81.6-55.15 parts of water. The invention provides a preparation method of a lasting and effective antipyretic patch. The cooling paste has high water content and good cooling effect.

Description

Lasting and effective antipyretic patch and preparation method thereof

Technical Field

The invention belongs to the field of polymer hydrogel and a preparation method thereof, and particularly relates to a lasting and effective antipyretic patch and a preparation method thereof.

Background

When a heat source occurs in a human body, the human body is often heated. Essentially, fever is a manifestation of the body's resistance, the process of which is a battle against the clearance of pathogenic agents by leukocytes. When the fever is higher than 39 ℃, the temperature of a patient needs to be reduced to below 39 ℃ by a physical cooling method besides keeping the ambient environment quiet and the patient lying in bed for rest, so as to avoid the functional disorder of the body and aggravate the illness. Especially for children with low immunity, before finding out the pathogenic cause, physical cooling is adopted, and the children cannot be forcibly treated by using antipyretic so as to avoid covering the pathogenic cause and missing the optimal treatment time. The common physical cooling methods include ice application and alcohol wiping. The former has limited continuous cooling time, insufficient fitting degree with the affected part and inconvenient operation for the patient without nursing. The latter has obvious cooling effect, but has strong skin irritation and is easy to cause damage to the health of infants.

The cooling paste belongs to physical cooling, and plays a role in cooling by pasting the cooling paste on the forehead, the palm and the sole of a patient and utilizing the principle that water in the paste is quickly evaporated to take away heat. The commercially available antipyretic patch is often limited in water content, resulting in poor heat dissipation effect, short action time, infirm adhesion and poor comfort for users, and is ideal in effect.

Disclosure of Invention

The invention aims to solve the problem that the existing cooling paste is low in water content and poor in cooling effect, and provides a lasting and effective cooling paste and a preparation method thereof.

In order to solve the problems, the invention adopts the technical scheme that:

the invention firstly provides a lasting and effective cooling paste which sequentially comprises an embossing film layer, a hydrogel layer and a non-woven fabric layer from bottom to top, wherein the hydrogel layer comprises the following raw materials in parts by weight:

3-7 parts of sodium polyacrylate, 15-25 parts of glycerol, 0.1-0.35 part of cross-linking agent, 0.05-0.25 part of cross-linking regulator, 0.05-0.25 part of forming agent, 0-2 parts of forming regulator, 0.05-2 parts of dispersing agent, 0.05-2 parts of traditional Chinese medicine extracting solution, 0-2 parts of borneol, 0.05-2 parts of alcohol, 0.05-2 parts of bacteriostatic agent and 81.6-55.15 parts of water.

Preferably, the hydrogel layer comprises the following raw materials in parts by weight:

5 parts of sodium polyacrylate, 20 parts of glycerol, 0.2 part of a cross-linking agent, 0.1 part of a cross-linking regulator, 0.05 part of a forming agent, 0.05 part of a forming regulator, 0.1 part of a dispersing agent, 0.05 part of a traditional Chinese medicine extracting solution, 1 part of borneol, 0.05 part of alcohol, 0.1 part of a bacteriostatic agent and 74.5 parts of water.

Preferably, the cross-linking agent is one or a mixture of aluminum glycollate or aluminum hydroxide.

Preferably, the crosslinking regulator is one or more of EDTA-2Na, EDTA-4Na or aluminum hydroxide.

Preferably, the forming agent is one or two of kaolin or titanium dioxide.

Preferably, the molding modifier is CMC-Na.

Preferably, the dispersant is PVPP.

Preferably, the traditional Chinese medicine extracting solution is one or more of mint, dandelion, honeysuckle, fructus forsythiae and ginkgo leaves.

Preferably, the bacteriostatic agent is methyl benzoate.

The invention also provides a preparation method of the lasting and effective antipyretic patch, which comprises the following steps:

(1) mixing sodium polyacrylate, cross-linking agent and glycerol, and stirring at normal temperature for 10-15 min to form a first mixture;

(2) dissolving the Chinese medicinal extractive solution and Borneolum Syntheticum in ethanol at room temperature to obtain a second mixture;

(3) dissolving the crosslinking regulator, the forming agent, the dispersing agent, the second mixture and the bacteriostatic agent in water, and stirring for 10-15 minutes at normal temperature to form a uniform water phase to obtain a third mixture;

(4) pouring the third mixture into a vacuum stirring kettle, adding the first mixture, stirring at the normal temperature for 20-25 minutes at the stirring speed of 2000-2500 rmp/min to form a bubble-free hydrogel colloidal material;

(5) coating the hydrogel colloid material, sticking an embossing film, shearing, curing and packaging to obtain the lasting and effective antipyretic patch.

The invention has the advantages of

1. The non-woven fabric has the advantages of good air permeability, bending resistance, comfortable touch feeling and the like, is beneficial to volatilization of heated moisture, and improves the heat dissipation efficiency;

2. the invention utilizes the sodium polyacrylate to construct the hydrogel structure with large water content, and the water is heated and is more easily volatilized through the principle of cold-heat exchange, thereby playing the effect of lasting temperature reduction.

3. The borneol and the traditional Chinese medicine extracting solution are added in the auxiliary manner, the borneol can quickly take away a part of heat after sublimation, the use comfort is enhanced, and the traditional Chinese medicine components can directly permeate into a human body through pores to play a role in cooling and reducing fever.

Drawings

Fig. 1 is a schematic structural diagram of a permanent effective cooling patch of the present invention.

Detailed Description

The invention firstly provides a lasting and effective cooling paste, as shown in figure 1, which sequentially comprises an embossing film layer 3, a hydrogel layer 2 and a non-woven fabric layer 1 from bottom to top, wherein the hydrogel layer 2 comprises the following raw materials in parts by weight:

3-7 parts of sodium polyacrylate, 15-25 parts of glycerol, 0.1-0.35 part of cross-linking agent, 0.05-0.25 part of cross-linking regulator, 0.05-0.25 part of forming agent, 0-2 parts of forming regulator, 0.05-2 parts of dispersing agent, 0.05-2 parts of traditional Chinese medicine extracting solution, 0-2 parts of borneol, 0.05-2 parts of alcohol, 0.05-2 parts of bacteriostatic agent and 81.6-55.15 parts of water.

Preferably, the traditional Chinese medicine composition comprises 5 parts of sodium polyacrylate, 20 parts of glycerol, 0.2 part of cross-linking agent, 0.1 part of cross-linking regulator, 0.05 part of forming agent, 0.05 part of forming regulator, 0.1 part of dispersing agent, 0.05 part of traditional Chinese medicine extracting solution, 1 part of borneol, 0.05 part of alcohol, 0.1 part of bacteriostatic agent and 74.5 parts of water.

According to the invention, the crosslinking agent is preferably one or a mixture of aluminum glycollate or aluminum hydroxide.

According to the invention, the crosslinking regulator is preferably one or more of EDTA-2Na, EDTA-4Na or aluminum hydroxide.

According to the invention, the forming agent is preferably one or two of kaolin or titanium dioxide.

According to the invention, the shaping modifier is preferably CMC-Na.

According to the invention, the dispersant is preferably PVPP.

According to the invention, the traditional Chinese medicine extracting solution is preferably one or more of mint, dandelion, honeysuckle, fructus forsythiae and ginkgo leaves.

According to the invention, the bacteriostatic agent is preferably methyl benzoate.

The invention also provides a preparation method of the lasting and effective antipyretic patch, which comprises the following steps:

(1) mixing sodium polyacrylate, cross-linking agent and glycerol, and stirring at normal temperature for 10-15 min to form a first mixture;

(2) dissolving the Chinese medicinal extractive solution and Borneolum Syntheticum in ethanol at room temperature to obtain a second mixture;

(3) dissolving the crosslinking regulator, the forming agent, the dispersing agent, the second mixture and the bacteriostatic agent in water, and stirring for 10-15 minutes at normal temperature to form a uniform water phase to obtain a third mixture;

(4) pouring the third mixture into a vacuum stirring kettle, adding the first mixture, stirring at the normal temperature for 20-25 minutes at the stirring speed of 2000-2500 rmp/min to form a bubble-free hydrogel colloidal material;

(5) coating hydrogel colloid material, sticking embossed film, cutting, solidifying and packaging so as to obtain the invented permanent effective defervescence plaster

The invention is further described with reference to the following examples, which are all commercially available, but are not intended to limit the scope of the invention.

Example 1

A long-lasting effective cooling and heat clearing plaster comprises an embossing film layer 3, a hydrogel layer 2 and a non-woven fabric layer 1 from bottom to top in sequence as shown in figure 1, wherein the hydrogel layer 2 comprises the following raw materials in parts by weight:

3g of sodium polyacrylate, 15g of glycerol, 0.1g of dihydroxyaluminium aminoacetate, 0.05g of EDTA-2Na, 0.05g of kaolin, 0.05g of PVPPP, 0.05g of mint extract, 0.05g of alcohol, 0.05g of methyl benzoate and 81.6g of water.

The preparation method of the cooling and heat clearing plaster comprises the following steps:

(1) mixing sodium polyacrylate, aluminium glycollate and glycerol, and stirring at normal temperature for 10 min to obtain a first mixture;

(2) dissolving the peppermint extract in alcohol at normal temperature to obtain a second mixture;

(3) dissolving EDTA-2Na, kaolin, PVPP, the second mixture and methyl benzoate in a water phase, and stirring for 10 minutes at normal temperature to form a uniform water phase to obtain a third mixture;

(4) pouring the third mixture into a vacuum stirring kettle, slowly stirring the first mixture for 20 minutes at normal temperature at the stirring speed of 2000 rmp/min to form a bubble-free hydrogel colloid material;

(5) coating, sticking embossed film, cutting, solidifying and packaging.

(6) Cutting a proper amount of the product, carrying out freeze-drying treatment, and measuring the water content according to the following formula to obtain the water content of 81.6%.

Example 2

A long-lasting effective cooling and heat clearing plaster comprises an embossing film layer 3, a hydrogel layer 2 and a non-woven fabric layer 1 from bottom to top in sequence as shown in figure 1, wherein the hydrogel layer 2 comprises the following raw materials in parts by weight:

5g of sodium polyacrylate, 20g of glycerol, 0.2g of dihydroxyaluminium aminoacetate, 0.1g of EDTA-2Na, 0.05g of kaolin, 0.05g of CMC-Na0, 0.1g of PVPP, 0.05g of mint traditional Chinese medicine extract, 1g of borneol, 0.05g of alcohol, 0.1g of methyl benzoate and 74.5g of water.

The preparation method of the cooling and heat clearing plaster comprises the following steps:

(1) mixing sodium polyacrylate, aluminium glycollate and glycerol, and stirring at normal temperature for 10 min to obtain a first mixture;

(2) dissolving herba Menthae extract and Borneolum Syntheticum in ethanol at room temperature to obtain a second mixture;

(3) dissolving EDTA-2Na, kaolin, CMC-Na, PVPP, the second mixture and methyl benzoate in the water phase, and stirring for 10 minutes at normal temperature to form a uniform water phase to obtain a third mixture;

(4) pouring the third mixture into a vacuum stirring kettle, slowly stirring the first mixture for 20 minutes at normal temperature at the stirring speed of 2000 rmp/min to form a bubble-free hydrogel colloid material;

(5) coating, sticking embossed film, cutting, solidifying and packaging.

(6) Cutting a proper amount of the product, carrying out freeze-drying treatment, and measuring the water content according to the following formula to obtain the water content of 74.5%.

Example 3

A long-lasting effective cooling and heat clearing plaster comprises an embossing film layer 3, a hydrogel layer 2 and a non-woven fabric layer 1 from bottom to top in sequence as shown in figure 1, wherein the hydrogel layer 2 comprises the following raw materials in parts by weight:

7g of sodium polyacrylate, 25g of glycerol, 0.35g of dihydroxyaluminium aminoacetate, 0.25g of EDTA-2Na, 0.25g of kaolin, CMC-Na2g, 2g of PVPP, 2g of mint traditional Chinese medicine extract, 2g of borneol, 2g of alcohol, 2g of methyl benzoate and 81.6g of water.

The preparation method of the cooling and heat clearing plaster comprises the following steps:

(1) mixing sodium polyacrylate, aluminium glycollate and glycerol, and stirring at normal temperature for 10 min to obtain a first mixture;

(2) dissolving herba Menthae extract and Borneolum Syntheticum in ethanol at room temperature to obtain a second mixture;

(3) dissolving EDTA-2Na, kaolin, CMC-Na, PVPP, the second mixture and methyl benzoate in the water phase, and stirring for 10 minutes at normal temperature to form a uniform water phase to obtain a third mixture;

(4) pouring the third mixture into a vacuum stirring kettle, slowly stirring the first mixture for 20 minutes at normal temperature at the stirring speed of 2000 rmp/min to form a bubble-free hydrogel colloid material;

(5) coating, sticking embossed film, cutting, solidifying and packaging.

(6) Cutting a proper amount of the product, carrying out freeze-drying treatment, and measuring the water content according to the following formula to obtain the water content of 81.6%.

Claims (1)

1. The utility model provides a lasting effective subsides of bringing down a fever, from the bottom up includes impressed watermark rete, hydrogel layer and non-woven fabrics layer in proper order, its characterized in that, hydrogel layer, count according to parts by weight, include following raw materials:

3-7 parts of sodium polyacrylate, 15-25 parts of glycerol, 0.1-0.35 part of cross-linking agent, 0.05-0.25 part of cross-linking regulator, 0.05-0.25 part of forming agent, 0-2 parts of forming regulator, 0.05-2 parts of dispersing agent, 0.05-2 parts of traditional Chinese medicine extracting solution, 0-2 parts of borneol, 0.05-2 parts of alcohol, 0.05-2 parts of bacteriostatic agent and 81.6-55.15 parts of water;

the traditional Chinese medicine extracting solution is one or more of mint, dandelion, honeysuckle, fructus forsythiae and ginkgo leaves;

the bacteriostatic agent is methyl benzoate;

the cross-linking agent is one or a mixture of dihydroxyaluminum glycinate and aluminum hydroxide;

the crosslinking regulator is one or more of EDTA-2Na, EDTA-4Na or aluminum hydroxide;

the forming agent is one or two of kaolin or titanium dioxide;

the molding regulator is CMC-Na;

the dispersing agent is PVPP;

the preparation method of the lasting and effective antipyretic patch comprises the following steps:

(1) mixing sodium polyacrylate, cross-linking agent and glycerol, and stirring at normal temperature for 10-15 min to form a first mixture;

(2) dissolving the Chinese medicinal extractive solution and Borneolum Syntheticum in ethanol at room temperature to obtain a second mixture;

(3) dissolving the crosslinking regulator, the forming agent, the dispersing agent, the second mixture and the bacteriostatic agent in water, and stirring for 10-15 minutes at normal temperature to form a uniform water phase to obtain a third mixture;

(4) pouring the third mixture into a vacuum stirring kettle, adding the first mixture, stirring at the normal temperature for 20-25 minutes at the stirring speed of 2000-2500rmp to form a bubble-free hydrogel colloidal material;

(5) coating the hydrogel colloid material, sticking an embossing film, shearing, curing and packaging to obtain the lasting and effective antipyretic patch.

Images