CN109662993A - It is medical defervescence plaster used and preparation method thereof - Google Patents
It is medical defervescence plaster used and preparation method thereof Download PDFInfo
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- CN109662993A CN109662993A CN201910053510.8A CN201910053510A CN109662993A CN 109662993 A CN109662993 A CN 109662993A CN 201910053510 A CN201910053510 A CN 201910053510A CN 109662993 A CN109662993 A CN 109662993A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F7/03—Compresses or poultices for effecting heating or cooling thermophore, i.e. self-heating, e.g. using a chemical reaction
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
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Abstract
The present invention provides a kind of medical defervescence plaster used, including back sheet, gel layer, coating, gel layer be made by each raw material, and each raw material is in terms of mass fraction, 80-120 parts of Chinese medical concrete, 20-35 parts of polymer substance, 15-30 parts of bleeding agent, 20-50 parts of purified water；Chinese medical concrete includes following parts by weight Chinese medicine: 20-30 parts of Radix Isatidis, 5-15 parts of radix saposhnikoviae, 15-30 parts of radix scutellariae, 15-30 parts of Radix Glycyrrhizae, 3-10 parts of honeysuckle, 10-20 parts of bupleurum extract.The present invention also provides a kind of medical defervescence plaster used preparation methods.The beneficial effects of the present invention are: it is of the present invention medical defervescence plaster used containing pure natural Chinese herbal medicine, heat evil, while regulating the function of the liver and spleen and stomach are released using accord method, this product is external use plaster, and soft, tack is strong, it is easy to use, it is highly-safe, it can be used for children；Medical defervescence plaster used preparation method of the present invention is easy to operate, raw material sources are extensive, preparation cost is cheap.
Description
Technical field
Field of medical article technology of the present invention, more particularly to it is a kind of medical defervescence plaster used and preparation method thereof.
Background technique
When " pyrogen " occurs in human body, often cause human body fever, for essence, fever is body in fact
Has resistive performance, process is the fight that leucocyte understands virulence factor.When fever is higher than 39 DEG C, except holding
Patient's rest is outer, also in time to put question to patient near safe range, avoids causing function of collective sexual disorder, the state of an illness is caused to add
Weight.In particular for the children that immunity is poor, pathogenesis money, Ying Caiyong Physical temperature-lowering are being found, rather than is being used by force
Antipyretic is treated, in order to avoid covering the cause of disease, misses best occasion for the treatment.
The method of common Physical temperature-lowering has ice compress method, alcohol wipe method, pastes defervescence plaster used etc., but the sustainable drop of ice compress method
Warm limited time, it is inadequate with the compactness in affected part, along with comfort level is inadequate, cause to be difficult to children and infant；Alcohol
Although wipe method cooling effect is obvious, strong to skin irritation, it is easy to damage infantile health；It is defervescence plaster used to belong to day
Normal most common physical cooling method, but commercially available defervescence plaster used water content is larger, and heat dissipation effect is poor, is pasted not strongly, in addition greatly
The commercially available defervescence plaster used only cooling effect in part, without any therapeutic effect, therefore when treating high fever, it is still desirable to itself and oral medicine
Object uses simultaneously.
Summary of the invention
One of the technical problems to be solved by the present invention are: to solve above-mentioned technical problem, it provides a kind of medical defervescence plaster used
And preparation method, larger to solve commercially available defervescence plaster used water content, heat dissipation effect is poor, is pasted not strongly, without any therapeutic effect
Problem.
The technical scheme adopted by the invention is that:
It is medical defervescence plaster used that the present invention provides one kind, including back sheet, gel layer, coating, the gel layer are by each raw material system
, each raw material is in terms of mass fraction, 80-120 parts of Chinese medical concrete, 20-35 parts of polymer substance, 15-30 parts of bleeding agent, purified water
20-50 parts；The Chinese medical concrete includes following parts by weight Chinese medicine: 20-30 parts of Radix Isatidis, 5-15 parts of radix saposhnikoviae, 15-30 parts of radix scutellariae,
15-30 parts of Radix Glycyrrhizae, 3-10 parts of honeysuckle, 10-20 parts of bupleurum extract.
Preferably, the gel layer is made by each raw material, and each raw material is in terms of mass fraction, 95 parts of Chinese medical concrete, high score
28 parts of sub- substance, 22 parts of bleeding agent, 42 parts of purified water；The Chinese medical concrete includes following parts by weight Chinese medicine: 26 parts of Radix Isatidis is prevented
12 parts of wind, 25 parts of radix scutellariae, 22 parts of Radix Glycyrrhizae, 5 parts of Honegsukle flower P.E, 14 parts of bupleurum extract.
Preferably, the polymer substance is one of carbomer, hydroxypropyl methyl cellulose sodium, chitosan or one kind
Above mixture.
Preferably, the bleeding agent is one of menthol, borneol, essential oil.
Preferably, the bleeding agent is one of Laurocapram, propylene glycol or more than one mixture.
Preferably, the bleeding agent is one of volatile clove oil, eucalyptus oil, cinnamon oil.
Preferably, the radix bupleuri extracting solution is to mix after crushing radix bupleuri with water, first adds cellulase and carries out at enzymatic hydrolysis
Then reason carries out decocting extraction, filtering, gained supernatant is precipitated with dehydrated alcohol, refiltered, and gained supernatant is removed anhydrous
The medical fluid obtained after ethyl alcohol.
Preferably, the extracting mode of the Chinese medical concrete is as follows:
Step A: it is spare to prepare radix bupleuri extracting solution；
Step B: Radix Isatidis, radix saposhnikoviae, radix scutellariae, Radix Glycyrrhizae, flos lonicerae material are cleaned, crushed and sieved with 100 mesh sieve, is added 2-3 times
75% ethanol water of parts by weight impregnates 20-40 minutes；
Step C: radix bupleuri extracting solution obtained in step A is added in the mixed solution in step B, then ultrasound 20-30 minutes,
Refluxing extraction, gained fraction are concentrated into 0.8-1.5 times of former Chinese medicine weight to get Chinese medical concrete.
Preferably, the back sheet is non-woven fabrics or compound nonwoven cloth, and the coating is film layer, polypropylene
One of film layer, polycarbonate film layer.
The present invention provides a kind of medical defervescence plaster used preparation method, the specific steps are as follows:
Step 1: spare after weighing each raw material according to the proportion speed of each raw material；
Step 2: by the purified water of the mass parts such as polymer substance addition, polymer substance being made to impregnate swelling under normal temperature conditions
Then 15-30min is added the purified water of remainder and stirs 10-20min with the stirring rate of 60-100r/min, stirring is mixed
It is spare as component one after even；
Step 3: Chinese medical concrete is prepared, it is spare as component two；
Step 4: component two being added in component one and is mixed, is stirred under normal temperature condition with the stirring rate of 100-180r/min
Mix 20-40min to be uniformly mixed；
Step 5: bleeding agent being added into mixture obtained in step 4, the stirring rate of 60-100r/min stirs 30-50min
Extremely it is uniformly mixed；
Step 6: gained mixture in step 5 being spread evenly across on back sheet, upper caldding layer is pressed, clipped, solidification, packaging are
Obtain medical defervescence plaster used finished product.
Preferably, immersion swelling time described in step 2 is 22 minutes, and the stirring rate is 85r/min, when stirring
Between be 16min；Stirring rate described in step 4 is 140r/min, mixing time 30min；The speed of stirring described in step 5
Rate is 82r/min, mixing time 42min.
The beneficial effects of the present invention are:
1. of the present invention medical defervescence plaster used containing pure natural Chinese herbal medicine, heat evil is released using the method for reconciliation, while reconciling liver
Spleen and stomach have effects that clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, antibacterial anti-inflammatory, alleviate dizziness headache, be completely suitable for children.
2. it is of the present invention it is medical it is defervescence plaster used be external use plaster, soft, tack is strong, easy to use, has good
Penetrability, gas permeability the advantages that, and it is without any side effects, it is highly-safe, be applicable to children；
3. medical defervescence plaster used preparation method of the present invention is easy to operate, raw material sources are extensive, preparation cost is cheap, use
Securely and reliably.
Detailed description of the invention
Fig. 1 is cross section structure schematic diagram of the present invention.
Wherein, 1- coating 2- gel layer 3- back sheet.
Specific embodiment
Embodiment 1:
It is a kind of medical defervescence plaster used, including back sheet, gel layer, coating, the gel layer are made by each raw material, each raw material with
Mass fraction meter, 80 parts of Chinese medical concrete, 20 parts of polymer substance, 15 parts of bleeding agent, 25 parts of purified water；The Chinese medical concrete includes
Following parts by weight Chinese medicine: 25 parts of Radix Isatidis, windproof 5 parts, 15 parts of radix scutellariae, 15 parts of Radix Glycyrrhizae, 3 parts of honeysuckle, 17 parts of bupleurum extract.
The polymer substance is carbomer.
The bleeding agent is menthol.
The radix bupleuri extracting solution is to mix after crushing radix bupleuri with water, first adds cellulase and carries out enzymolysis processing, then
Decocting extraction, filtering are carried out, gained supernatant is precipitated with dehydrated alcohol, refiltered, after gained supernatant is removed dehydrated alcohol
Obtained medical fluid.
The extracting mode of the Chinese medical concrete is as follows:
Step A: it is spare to prepare radix bupleuri extracting solution；
Step B: Radix Isatidis, radix saposhnikoviae, radix scutellariae, Radix Glycyrrhizae, flos lonicerae material are cleaned, crushed and sieved with 100 mesh sieve, is added 2.3 times
75% ethanol water of parts by weight impregnates 26 minutes；
Step C: radix bupleuri extracting solution obtained in step A is added in the mixed solution in step B, then ultrasound 22 minutes, is returned
Stream extracts, and gained fraction is concentrated into 1.2 times of former Chinese medicine weight to get Chinese medical concrete.
The back sheet is non-woven fabrics, and the coating is film layer.
Above-mentioned medical defervescence plaster used preparation method, the specific steps are as follows:
Step 1: spare after weighing each raw material according to the proportion speed of each raw material；
Step 2: by the purified water of the mass parts such as polymer substance addition, polymer substance being made to impregnate swelling under normal temperature conditions
Then 15min is added the purified water of remainder and stirs 10min with the stirring rate of 60r/min, after stirring and evenly mixing, as
Component one is spare；
Step 3: Chinese medical concrete is prepared, it is spare as component two；
Step 4: component two being added in component one and is mixed, is stirred under normal temperature condition with the stirring rate of 100r/min
20min to be uniformly mixed；
Step 5: bleeding agent being added into mixture obtained in step 4, the stirring rate stirring 30min of 60r/min is extremely mixed
Uniformly；
Step 6: gained mixture in step 5 being spread evenly across on back sheet, upper caldding layer is pressed, clipped, solidification, packaging are
Obtain medical defervescence plaster used finished product.
Embodiment 2
It is a kind of medical defervescence plaster used, including back sheet, gel layer, coating, the gel layer are made by each raw material, each raw material with
Mass fraction meter, 90 parts of Chinese medical concrete, 25 parts of polymer substance, 23 parts of bleeding agent, 38 parts of purifying；The Chinese medical concrete includes such as
Lower parts by weight Chinese medicine: 20 parts of Radix Isatidis, windproof 10 parts, 22 parts of radix scutellariae, 18 parts of Radix Glycyrrhizae, 7 parts of honeysuckle, 13 parts of bupleurum extract.
The polymer substance is hydroxypropyl methyl cellulose sodium.
The bleeding agent is borneol.
The radix bupleuri extracting solution is to mix after crushing radix bupleuri with water, first adds cellulase and carries out enzymolysis processing, then
Decocting extraction, filtering are carried out, gained supernatant is precipitated with dehydrated alcohol, refiltered, after gained supernatant is removed dehydrated alcohol
Obtained medical fluid.
The extracting mode of the Chinese medical concrete is as follows:
Step A: it is spare to prepare radix bupleuri extracting solution；
Step B: Radix Isatidis, radix saposhnikoviae, radix scutellariae, Radix Glycyrrhizae, flos lonicerae material are cleaned, crushed and sieved with 100 mesh sieve, 2 times of weights are added
75% ethanol water for measuring part impregnates 40 minutes；
Step C: radix bupleuri extracting solution obtained in step A is added in the mixed solution in step B, then ultrasound 20 minutes, is returned
Stream extracts, and gained fraction is concentrated into 1.0 times of former Chinese medicine weight to get Chinese medical concrete.
The back sheet is non-woven fabrics, and the coating is film layer.
Above-mentioned medical defervescence plaster used preparation method, the specific steps are as follows:
Step 1: spare after weighing each raw material according to the proportion speed of each raw material；
Step 2: by the purified water of the mass parts such as polymer substance addition, polymer substance being made to impregnate swelling under normal temperature conditions
Then 19min is added the purified water of remainder and stirs 15min with the stirring rate of 75r/min, after stirring and evenly mixing, as
Component one is spare；
Step 3: Chinese medical concrete is prepared, it is spare as component two；
Step 4: component two being added in component one and is mixed, is stirred under normal temperature condition with the stirring rate of 136r/min
28min to be uniformly mixed；
Step 5: bleeding agent being added into mixture obtained in step 4, the stirring rate stirring 39min of 82r/min is extremely mixed
Uniformly；
Step 6: gained mixture in step 5 being spread evenly across on back sheet, upper caldding layer is pressed, clipped, solidification, packaging are
Obtain medical defervescence plaster used finished product.
Embodiment 3:
It is a kind of medical defervescence plaster used, including back sheet, gel layer, coating, the gel layer are made by each raw material, each raw material with
Mass fraction meter, 95 parts of Chinese medical concrete, 28 parts of polymer substance, 22 parts of bleeding agent, 42 parts of purified water；The Chinese medical concrete includes
Following parts by weight Chinese medicine: 26 parts of Radix Isatidis, 12 parts of radix saposhnikoviae, 25 parts of radix scutellariae, 22 parts of Radix Glycyrrhizae, 5 parts of Honegsukle flower P.E, radix bupleuri extract
14 parts of object.
The polymer substance is carbomer.
The bleeding agent is eucalyptus oil.
The radix bupleuri extracting solution is to mix after crushing radix bupleuri with water, first adds cellulase and carries out enzymolysis processing, then
Decocting extraction, filtering are carried out, gained supernatant is precipitated with dehydrated alcohol, refiltered, after gained supernatant is removed dehydrated alcohol
Obtained medical fluid.
The extracting mode of the Chinese medical concrete is as follows:
Step A: it is spare to prepare radix bupleuri extracting solution；
Step B: Radix Isatidis, radix saposhnikoviae, radix scutellariae, Radix Glycyrrhizae, flos lonicerae material are cleaned, crushed and sieved with 100 mesh sieve, 3 times of weights are added
75% ethanol water for measuring part impregnates 40 minutes；
Step C: radix bupleuri extracting solution obtained in step A is added in the mixed solution in step B, then ultrasound 25 minutes, is returned
Stream extracts, and gained fraction is concentrated into 1.5 times of former Chinese medicine weight to get Chinese medical concrete.
The back sheet is compound nonwoven cloth, and the coating is polycarbonate film layer.
Above-mentioned medical defervescence plaster used preparation method, the specific steps are as follows:
Step 1: spare after weighing each raw material according to the proportion speed of each raw material；
Step 2: by the purified water of the mass parts such as polymer substance addition, polymer substance being made to impregnate swelling under normal temperature conditions
Then 22min is added the purified water of remainder and stirs 106min with the stirring rate of 85r/min, after stirring and evenly mixing, as
Component one is spare；
Step 3: Chinese medical concrete is prepared, it is spare as component two；
Step 4: component two being added in component one and is mixed, is stirred under normal temperature condition with the stirring rate of 140r/min
30min to be uniformly mixed；
Step 5: bleeding agent being added into mixture obtained in step 4, the stirring rate stirring 42min of 82r/min is extremely mixed
Uniformly；
Step 6: gained mixture in step 5 being spread evenly across on back sheet, upper caldding layer is pressed, clipped, solidification, packaging are
Obtain medical defervescence plaster used finished product.
Embodiment 4:
It is a kind of medical defervescence plaster used, including back sheet, gel layer, coating, the gel layer are made by each raw material, each raw material with
Mass fraction meter, 120 parts of Chinese medical concrete, 35 parts of polymer substance, 30 parts of bleeding agent, 50 parts of purified water；The Chinese medical concrete packet
Include following parts by weight Chinese medicine: 30 parts of Radix Isatidis, windproof 15 parts, 25 parts of radix scutellariae, 22 parts of Radix Glycyrrhizae, 8 parts of honeysuckle, bupleurum extract 20
Part.
The polymer substance is chitosan.
The bleeding agent is Laurocapram.
The radix bupleuri extracting solution is to mix after crushing radix bupleuri with water, first adds cellulase and carries out enzymolysis processing, then
Decocting extraction, filtering are carried out, gained supernatant is precipitated with dehydrated alcohol, refiltered, after gained supernatant is removed dehydrated alcohol
Obtained medical fluid.
The extracting mode of the Chinese medical concrete is as follows:
Step A: it is spare to prepare radix bupleuri extracting solution；
Step B: Radix Isatidis, radix saposhnikoviae, radix scutellariae, Radix Glycyrrhizae, flos lonicerae material are cleaned, crushed and sieved with 100 mesh sieve, 3 times of weights are added
75% ethanol water for measuring part impregnates 40 minutes；
Step C: radix bupleuri extracting solution obtained in step A is added in the mixed solution in step B, then ultrasound 30 minutes, is returned
Stream extracts, and gained fraction is concentrated into 1.3 times of former Chinese medicine weight to get Chinese medical concrete.
The back sheet is compound nonwoven cloth, and the coating is layer of polypropylene foil.
Above-mentioned medical defervescence plaster used preparation method, the specific steps are as follows:
Step 1: spare after weighing each raw material according to the proportion speed of each raw material；
Step 2: by the purified water of the mass parts such as polymer substance addition, polymer substance being made to impregnate swelling under normal temperature conditions
Then 30min is added the purified water of remainder and stirs 20min with the stirring rate of 100r/min, after stirring and evenly mixing, as
Component one is spare；
Step 3: Chinese medical concrete is prepared, it is spare as component two；
Step 4: component two being added in component one and is mixed, is stirred under normal temperature condition with the stirring rate of 166r/min
38min to be uniformly mixed；
Step 5: bleeding agent being added into mixture obtained in step 4, the stirring rate stirring 45min of 100r/min is extremely mixed
Uniformly；
Step 6: gained mixture in step 5 being spread evenly across on back sheet, upper caldding layer is pressed, clipped, solidification, packaging are
Obtain medical defervescence plaster used finished product.
Embodiment 5:
It is a kind of medical defervescence plaster used, including back sheet, gel layer, coating, the gel layer are made by each raw material, each raw material with
Mass fraction meter, 90 parts of Chinese medical concrete, 25 parts of polymer substance, 23 parts of bleeding agent, 38 parts of purifying；The Chinese medical concrete includes such as
Lower parts by weight Chinese medicine: 20 parts of Radix Isatidis, windproof 10 parts, 22 parts of radix scutellariae, 18 parts of Radix Glycyrrhizae, 7 parts of honeysuckle, 13 parts of bupleurum extract.
The polymer substance is carbomer.
The bleeding agent is eucalyptus oil.
The radix bupleuri extracting solution is to mix after crushing radix bupleuri with water, first adds cellulase and carries out enzymolysis processing, then
Decocting extraction, filtering are carried out, gained supernatant is precipitated with dehydrated alcohol, refiltered, after gained supernatant is removed dehydrated alcohol
Obtained medical fluid.
The extracting mode of the Chinese medical concrete is as follows:
Step A: it is spare to prepare radix bupleuri extracting solution；
Step B: Radix Isatidis, radix saposhnikoviae, radix scutellariae, Radix Glycyrrhizae, flos lonicerae material are cleaned, crushed and sieved with 100 mesh sieve, 3 times of weights are added
75% ethanol water for measuring part impregnates 40 minutes；
Step C: radix bupleuri extracting solution obtained in step A is added in the mixed solution in step B, then ultrasound 25 minutes, is returned
Stream extracts, and gained fraction is concentrated into 1.5 times of former Chinese medicine weight to get Chinese medical concrete.
The back sheet is compound nonwoven cloth, and the coating is polycarbonate film layer.
Above-mentioned medical defervescence plaster used preparation method, the specific steps are as follows:
Step 1: spare after weighing each raw material according to the proportion speed of each raw material；
Step 2: by the purified water of the mass parts such as polymer substance addition, polymer substance being made to impregnate swelling under normal temperature conditions
Then 22min is added the purified water of remainder and stirs 106min with the stirring rate of 85r/min, after stirring and evenly mixing, as
Component one is spare；
Step 3: Chinese medical concrete is prepared, it is spare as component two；
Step 4: component two being added in component one and is mixed, is stirred under normal temperature condition with the stirring rate of 140r/min
30min to be uniformly mixed；
Step 5: bleeding agent being added into mixture obtained in step 4, the stirring rate stirring 42min of 82r/min is extremely mixed
Uniformly；
Step 6: gained mixture in step 5 being spread evenly across on back sheet, upper caldding layer is pressed, clipped, solidification, packaging are
Obtain medical defervescence plaster used finished product.
Embodiment 6:
It is a kind of medical defervescence plaster used, including back sheet, gel layer, coating, the gel layer are made by each raw material, each raw material with
Mass fraction meter, 95 parts of Chinese medical concrete, 28 parts of polymer substance, 22 parts of bleeding agent, 42 parts of purified water；The Chinese medical concrete includes
Following parts by weight Chinese medicine: 26 parts of Radix Isatidis, 12 parts of radix saposhnikoviae, 25 parts of radix scutellariae, 22 parts of Radix Glycyrrhizae, 5 parts of Honegsukle flower P.E, radix bupleuri extract
14 parts of object.
The polymer substance is chitosan.
The bleeding agent is Laurocapram.
The radix bupleuri extracting solution is to mix after crushing radix bupleuri with water, first adds cellulase and carries out enzymolysis processing, then
Decocting extraction, filtering are carried out, gained supernatant is precipitated with dehydrated alcohol, refiltered, after gained supernatant is removed dehydrated alcohol
Obtained medical fluid.
The extracting mode of the Chinese medical concrete is as follows:
Step A: it is spare to prepare radix bupleuri extracting solution；
Step B: Radix Isatidis, radix saposhnikoviae, radix scutellariae, Radix Glycyrrhizae, flos lonicerae material are cleaned, crushed and sieved with 100 mesh sieve, 3 times of weights are added
75% ethanol water for measuring part impregnates 40 minutes；
Step C: radix bupleuri extracting solution obtained in step A is added in the mixed solution in step B, then ultrasound 30 minutes, is returned
Stream extracts, and gained fraction is concentrated into 1.3 times of former Chinese medicine weight to get Chinese medical concrete.
The back sheet is compound nonwoven cloth, and the coating is layer of polypropylene foil.
Above-mentioned medical defervescence plaster used preparation method, the specific steps are as follows:
Step 1: spare after weighing each raw material according to the proportion speed of each raw material；
Step 2: by the purified water of the mass parts such as polymer substance addition, polymer substance being made to impregnate swelling under normal temperature conditions
Then 30min is added the purified water of remainder and stirs 20min with the stirring rate of 100r/min, after stirring and evenly mixing, as
Component one is spare；
Step 3: Chinese medical concrete is prepared, it is spare as component two；
Step 4: component two being added in component one and is mixed, is stirred under normal temperature condition with the stirring rate of 166r/min
38min to be uniformly mixed；
Step 5: bleeding agent being added into mixture obtained in step 4, the stirring rate stirring 45min of 100r/min is extremely mixed
Uniformly；
Step 6: gained mixture in step 5 being spread evenly across on back sheet, upper caldding layer is pressed, clipped, solidification, packaging are
Obtain medical defervescence plaster used finished product.
Embodiment 7:
It is a kind of medical defervescence plaster used, including back sheet, gel layer, coating, the gel layer are made by each raw material, each raw material with
Mass fraction meter, 120 parts of Chinese medical concrete, 35 parts of polymer substance, 30 parts of bleeding agent, 50 parts of purified water；The Chinese medical concrete packet
Include following parts by weight Chinese medicine: 30 parts of Radix Isatidis, windproof 15 parts, 25 parts of radix scutellariae, 22 parts of Radix Glycyrrhizae, 8 parts of honeysuckle, bupleurum extract 20
Part.
The polymer substance is chitosan.
The bleeding agent is Laurocapram.
The radix bupleuri extracting solution is to mix after crushing radix bupleuri with water, first adds cellulase and carries out enzymolysis processing, then
Decocting extraction, filtering are carried out, gained supernatant is precipitated with dehydrated alcohol, refiltered, after gained supernatant is removed dehydrated alcohol
Obtained medical fluid.
The extracting mode of the Chinese medical concrete is as follows:
Step A: it is spare to prepare radix bupleuri extracting solution；
Step B: Radix Isatidis, radix saposhnikoviae, radix scutellariae, Radix Glycyrrhizae, flos lonicerae material are cleaned, crushed and sieved with 100 mesh sieve, 3 times of weights are added
75% ethanol water for measuring part impregnates 40 minutes；
Step C: radix bupleuri extracting solution obtained in step A is added in the mixed solution in step B, then ultrasound 30 minutes, is returned
Stream extracts, and gained fraction is concentrated into 1.3 times of former Chinese medicine weight to get Chinese medical concrete.
The back sheet is compound nonwoven cloth, and the coating is layer of polypropylene foil.
Above-mentioned medical defervescence plaster used preparation method, the specific steps are as follows:
Step 1: spare after weighing each raw material according to the proportion speed of each raw material；
Step 2: by the purified water of the mass parts such as polymer substance addition, polymer substance being made to impregnate swelling under normal temperature conditions
Then 22min is added the purified water of remainder and stirs 106min with the stirring rate of 85r/min, after stirring and evenly mixing, as
Component one is spare；
Step 3: Chinese medical concrete is prepared, it is spare as component two；
Step 4: component two being added in component one and is mixed, is stirred under normal temperature condition with the stirring rate of 140r/min
30min to be uniformly mixed；
Step 5: bleeding agent being added into mixture obtained in step 4, the stirring rate stirring 42min of 82r/min is extremely mixed
Uniformly；
Step 6: gained mixture in step 5 being spread evenly across on back sheet, upper caldding layer is pressed, clipped, solidification, packaging are
Obtain medical defervescence plaster used finished product.
Clinical and drug efficacy study
Selection 140 has the infant of fever in children symptom, the age 1-5 years old, is randomly divided into experimental group 1, experimental group 2, experimental group
3, experimental group 4, experimental group 5, experimental group 6, experimental group 7, control group, every group of 20 people.Experimental group 1-7 is successively implemented using the present invention
Medical defervescence plaster used obtained by example 1-7, control group takes Western medicine (paracetamol).The results are shown in Table 1 for it, recovery from illness: using this
After product, heating paresthesia disappears, and the recoveries such as diet are normal；Effective: using after this product, heating paresthesia mitigates or partial disappearance；It is invalid:
After this product, heating paresthesia is unchanged.
Table 1
It can be seen that for effective percentage up to 99%, cure rate is of the present invention up to 94.3% using of the present invention medical defervescence plaster used
The medical defervescence plaster used therapeutic equivalence with oral antipyretic, but found during clinical test, compared with small children to oral medicine
Compliance it is poor, compare oral medicine, it is medical defervescence plaster used more convenient, safe and effective, be more suitable for children.
Specific embodiments of the present invention are only a part of the embodiments of the present invention, instead of all the embodiments, are not constituted
Limitation of the present invention.Based on the embodiments of the present invention, those of ordinary skill in the art are not before making creative work
Every other embodiment obtained is put, shall fall within the protection scope of the present invention.
Claims (10)
1. it is a kind of medical defervescence plaster used, including back sheet, gel layer, coating, which is characterized in that the gel layer is by each raw material
It is made, each raw material is in terms of mass fraction, 80-120 parts of Chinese medical concrete, 20-35 parts of polymer substance, 15-30 parts of bleeding agent, purifying
20-50 parts of water；The Chinese medical concrete includes following parts by weight Chinese medicine: 20-30 parts of Radix Isatidis, 5-15 parts of radix saposhnikoviae, radix scutellariae 15-30
Part, 15-30 parts of Radix Glycyrrhizae, 3-10 parts of honeysuckle, 10-20 parts of bupleurum extract.
2. one kind according to claim 1 is medical defervescence plaster used, including back sheet, gel layer, coating, which is characterized in that
The gel layer is made by each raw material, and each raw material is in terms of mass fraction, 95 parts of Chinese medical concrete, 28 parts of polymer substance, infiltration
22 parts of agent, 42 parts of purified water；The Chinese medical concrete includes following parts by weight Chinese medicine: 26 parts of Radix Isatidis, windproof 12 parts, radix scutellariae 25
Part, 22 parts of Radix Glycyrrhizae, 5 parts of Honegsukle flower P.E, 14 parts of bupleurum extract.
3. according to claim 1 or one kind described in 2 is medical defervescence plaster used, which is characterized in that the polymer substance is card wave
One of nurse, hydroxypropyl methyl cellulose sodium, chitosan or more than one mixture.
4. according to claim 1 or one kind described in 2 is medical defervescence plaster used, which is characterized in that the bleeding agent is menthol, ice
One of piece, essential oil.
5. one kind according to claim 4 is medical defervescence plaster used, which is characterized in that the bleeding agent be volatile clove oil,
One of eucalyptus oil, cinnamon oil.
6. according to claim 1 or one kind described in 2 is medical defervescence plaster used, which is characterized in that the bleeding agent is that laurel nitrogen is tall and erect
One of ketone, propylene glycol or more than one mixture.
7. according to claim 1 or one kind described in 2 is medical defervescence plaster used, which is characterized in that the radix bupleuri extracting solution is by bavin
It is mixed after English white is broken with water, first adds cellulase and carry out enzymolysis processing, then carry out decocting extraction, filtering, gained supernatant
It is precipitated, is refiltered with dehydrated alcohol, gained supernatant is removed to the medical fluid obtained after dehydrated alcohol.
8. according to claim 1 or one kind described in 2 is medical defervescence plaster used, which is characterized in that the extraction side of the Chinese medical concrete
Formula is as follows:
Step A: it is spare to prepare radix bupleuri extracting solution；
Step B: Radix Isatidis, radix saposhnikoviae, radix scutellariae, Radix Glycyrrhizae, flos lonicerae material are cleaned, crushed and sieved with 100 mesh sieve, is added 2-3 times
75% ethanol water of parts by weight impregnates 20-40 minutes；
Step C: radix bupleuri extracting solution obtained in step A is added in the mixed solution in step B, then ultrasound 20-30 minutes,
Refluxing extraction, gained fraction are concentrated into 0.8-1.5 times of former Chinese medicine weight to get Chinese medical concrete.
9. according to claim 1 or one kind described in 2 is medical defervescence plaster used, which is characterized in that the back sheet be non-woven fabrics or
Compound nonwoven cloth, the coating are one of film layer, layer of polypropylene foil, polycarbonate film layer.
10. according to claim 1 or the medical defervescence plaster used preparation method of one kind described in 2, which is characterized in that specific steps are such as
Under:
Step 1: spare after weighing each raw material according to the proportion speed of each raw material；
Step 2: by the purified water of the mass parts such as polymer substance addition, polymer substance being made to impregnate swelling under normal temperature conditions
Then 15-30min is added the purified water of remainder and stirs 10-20min with the stirring rate of 60-100r/min, stirring is mixed
It is spare as component one after even；
Step 3: Chinese medical concrete is prepared, it is spare as component two；
Step 4: component two being added in component one and is mixed, is stirred under normal temperature condition with the stirring rate of 100-180r/min
Mix 20-40min to be uniformly mixed；
Step 5: bleeding agent being added into mixture obtained in step 4, the stirring rate of 60-100r/min stirs 30-50min
Extremely it is uniformly mixed；
Step 6: gained mixture in step 5 being spread evenly across on back sheet, upper caldding layer is pressed, clipped, solidification, packaging are
Obtain medical defervescence plaster used finished product.
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Cited By (1)
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| CN111358920A (en) * | 2020-01-18 | 2020-07-03 | 日照海旭医疗器械有限公司 | Method for manufacturing medical cooling paste and matched cooling paste production equipment |
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