CN105796806A - Preparation method of traditional Chinese medicine ointment for treating acute or chronic traumatic injuries - Google Patents

Preparation method of traditional Chinese medicine ointment for treating acute or chronic traumatic injuries Download PDF

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CN105796806A
CN105796806A CN201610191792.4A CN201610191792A CN105796806A CN 105796806 A CN105796806 A CN 105796806A CN 201610191792 A CN201610191792 A CN 201610191792A CN 105796806 A CN105796806 A CN 105796806A
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mass ratio
polymer substance
polyoxyethylene
product
chronic traumatic
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梁立明
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Yantai Xinhui Pharmaceutical Technology Co Ltd
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Yantai Xinhui Pharmaceutical Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Engineering & Computer Science (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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Abstract

The invention relates to a preparation method of traditional Chinese medicine ointment for treating acute or chronic traumatic injuries.The preparation method includes the steps that radix angelica sinensis, flos carthami, dragon's blood, mastic, myrrh, cutch and water are added into a container according to a certain mass ratio and decocted for a certain time under a certain temperature condition, cooling and filtering are performed, filter liquor is obtained after filtering, the filter liquor, a macromolecular matter solution, a moisturizer, a natural freshener and a wetting penetrant are mixed according to a certain mass ratio, and the traditional Chinese medicine ointment for treating acute or chronic traumatic injuries is obtained.The traditional Chinese medicine ointment is in a paste state and has the advantages of being convenient to use and carry.

Description

A kind of preparation method of the Chinese medicinal ointment for treating acute and chronic traumatic injury
Technical field
The preparation method that the present invention relates to a kind of Chinese medicine, the preparation method being specifically related to a kind of Chinese medicinal ointment for treating acute and chronic traumatic injury.
Background technology
The Chinese medicine of traditional treatment traumatic injury is divided into oral drugs and liniment, and oral drug therapy effect is slow, takes and need to use mixing in water for oral taking, and directly oral taste bitterness is difficult to swallow；Liniment powder then needs ethanol mediation to spread on affected part, fixes with article such as gauze, binder and adhesive plasters, and external application liquid then needs to be wiped over by swab stick, and traumatic injury is paroxysmal often, and Chinese medicine is existing defects in using and carrying.
Medical material present Research involved in the present invention is as follows:
Radix Angelicae Sinensis, (formal name used at school: Angelicasinensis) call dry return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Radix Angelicae Sinensis, Radix Angelicae Sinensis body, contain that Radix Angelicae Sinensis, Radix Angelicae Sinensis be bent, Radix Angelicae Gigatis, there is benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation, anti-old, immune effect anticancer, anti-ageing.
Flos Carthami (Classification system: CarthamustinctoriusL.), another name: red blue flower, thorn Flos Carthami, there is promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, wet dissipation goes the effect swollen.
Sanguis Draxonis has another name called dragon's blood, black horse exhausts, and has analgesic therapy of invigorating blood circulation, removing stasis to stop bleeding, effect of promoting tissue regeneration and ulcer healing.
Olibanum has another name called nipple perfume (or spice), pool, sky perfume, has blood-activating and qi-promoting pain relieving, effect of detumescence and promoting granulation.
Myrrha has another name called myrrh, bright Myrrha, has dissipating blood stasis analgesic therapy, effect of detumescence and promoting granulation.
Catechu has another name called CATECHU, Catechu, crow father's mud, has promoting blood circulation and stopping pain, hemostasia and promoting granulation, removing dampness sore, effect of removing heat from the lung and dissipating phlegm.
Summary of the invention
It is desirable to provide the preparation method of a kind of Chinese medicinal ointment for treating acute and chronic traumatic injury, there is therapeutic effect good, easy to use, it is simple to the feature carried.
In order to achieve the above object, the present invention is by the following technical solutions:
The preparation method of a kind of Chinese medicinal ointment for treating acute and chronic traumatic injury, it is characterised in that carry out according to following steps:
1), product A is made: joining in container by Radix Angelicae Sinensis, Flos Carthami, Sanguis Draxonis, Olibanum, Myrrha, catechu and water according to certain mass ratio, decoct 20～120min, cold filtration under 80～100 DEG C of conditions, the filtrate obtained after filtration is product A；
And make polymer substance solution: joining in container by polymer substance and distilled water according to certain mass ratio, heating is to 80～100 DEG C, and stirring, to being completely dissolved, obtains polymer substance solution；
2), by product A, polymer substance solution, wetting agent, natural freshener and wetting and penetrating agent according to certain mass than mix homogeneously, be concentrated into paste, obtain the Chinese medicinal ointment for treating acute and chronic traumatic injury；
The mass ratio of described Radix Angelicae Sinensis, Flos Carthami, Sanguis Draxonis, Olibanum, Myrrha, catechu and water is 1～20:1～20:1～20:1～20:1～20:1～20:100～1000；
The mass ratio of described polymer substance and distilled water is 5～15:85～95；The mass ratio of described product A, polymer substance solution, wetting agent, natural freshener and wetting and penetrating agent is 45～75:5～35:0.5～10:0.5～10:0.5～10；
Described polymer substance is the two or more of a kind of or arbitrary proportion in polyacrylamide, sodium polyacrylate, sodium alginate, guar gum, sodium carboxymethyl cellulose and polyvinyl alcohol；Described wetting agent is the two or more of a kind of or arbitrary proportion in glycerol, propylene glycol and sorbitol；Described natural freshener is the two or more of a kind of or arbitrary proportion in Oleum menthae, menthol and Borneolum Syntheticum；Described wetting and penetrating agent is the two or more of a kind of or arbitrary proportion in alkylphenol polyoxyethylene, Sorbitan fatty acid ester-20, Sorbitan fatty acid ester-30, Sorbitan fatty acid ester-80, polyoxyethylene 20 sorbitan monolaurate-20, polyoxyethylene 20 sorbitan monolaurate-40, polyoxyethylene 20 sorbitan monolaurate-60, polyoxyethylene 20 sorbitan monolaurate-80 and dimethicone.
The present invention has following Advantageous Effects:
1, the present invention is paste, is applied directly to injury, easy to use, be easy to carry.
2, the present invention adds wetting agent, makes medicine keep long moisture state, be beneficial to the skin absorption to medicine after smearing.
3, the present invention adds natural freshener, and the volatilization smearing rear freshener can reduce the temperature in affected part, is conducive to alleviating pain and hemostasis.
4, the present invention adds wetting and penetrating agent, contributes to medicine rapid osmotic and enters skin, play curative effect, accelerate treatment after smearing.
5, Chinese medicine is combined by the present invention with multiple auxiliary agent, better plays the external effect of Chinese medicine.
Detailed description of the invention
In order to be more fully understood that and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
By Radix Angelicae Sinensis, Flos Carthami, Sanguis Draxonis, Olibanum, Myrrha, catechu and water join in container at 98 DEG C according to mass ratio 1:1:2:1:2:1:100, decoct 40min, cold filtration, the filtrate obtained after filtration is product A, by polyacrylamide, sodium polyacrylate and distilled water join in container according to mass ratio 3:3:94, it is heated to 85 DEG C, stirring is to being completely dissolved, obtain polymer substance solution, by product A, polymer substance solution, glycerol, propylene glycol, Oleum menthae, menthol, Borneolum Syntheticum, Sorbitan fatty acid ester-20 and Sorbitan fatty acid ester-30 are according to mass ratio 72:17:2:2:1:2:1:2:1 mix homogeneously, it is concentrated into paste, obtain the Chinese medicinal ointment for treating acute and chronic traumatic injury.
Embodiment 2
nullBy Radix Angelicae Sinensis、Flos Carthami、Sanguis Draxonis、Olibanum、Myrrha、Catechu and water join in container at 85 DEG C according to mass ratio 10:10:8:12:8:9:500，Decoct 100min，Cold filtration，The filtrate obtained after filtration is product A,By polyvinyl alcohol、Sodium polyacrylate、Sodium alginate and distilled water join in container according to mass ratio 6:3:2:89，It is heated to 97 DEG C，Stirring is to being completely dissolved，Obtain polymer substance solution，By product A、Polymer substance solution、Propylene glycol、Sorbitol、Oleum menthae、Menthol、Sorbitan fatty acid ester-20、Polyoxyethylene 20 sorbitan monolaurate-20 and polyoxyethylene 20 sorbitan monolaurate-40 are according to mass ratio 65:15:5:2:3:2:3:2:3 mix homogeneously，It is concentrated into paste，Obtain the Chinese medicinal ointment for treating acute and chronic traumatic injury.
Embodiment 3
By Radix Angelicae Sinensis, Flos Carthami, Sanguis Draxonis, Olibanum, Myrrha, catechu and water join in container at 90 DEG C according to mass ratio 20:19:16:12:16:14:1000, decoct 30min, cold filtration, the filtrate obtained after filtration is product A, by sodium alginate, sodium polyacrylate, sodium carboxymethyl cellulose and distilled water join in container according to mass ratio 2:7:3:88, it is heated to 90 DEG C, stirring is to being completely dissolved, obtain polymer substance solution, by product A, polymer substance solution, glycerol, menthol and polyoxyethylene 20 sorbitan monolaurate-40 are according to mass ratio 45:30:8:8:9 mix homogeneously, it is concentrated into paste, obtain the Chinese medicinal ointment for treating acute and chronic traumatic injury.
Embodiment 4
By Radix Angelicae Sinensis, Flos Carthami, Sanguis Draxonis, Olibanum, Myrrha, catechu and water join in container at 98 DEG C according to mass ratio 8:5:9:16:5:15:700, decoct 80min, cold filtration, the filtrate obtained after filtration is product A, by sodium alginate, sodium polyacrylate and distilled water join in container according to mass ratio 3:9:88, it is heated to 80 DEG C, stirring is to being completely dissolved, obtain polymer substance solution, by product A, polymer substance solution, glycerol, sorbitol, menthol, Borneolum Syntheticum and polyoxyethylene 20 sorbitan monolaurate-40 are according to mass ratio 60:25:5:2:3:2:3 mix homogeneously, it is concentrated into paste, obtain the Chinese medicinal ointment for treating acute and chronic traumatic injury.
Further illustrate below in conjunction with experimental data and the method have the benefit that
1, physical data
Big pharmacy, swallow wedding hall, North Street, Zhifu District, Yantai City, the raw big pharmacy of hall, the vertical sales situation being good for three kinds of pharmacy, three, big pharmacy (capsule pill, liquid medicine, ointment of the present invention) medicine, between in August, 2014～in November, 2015, are added up by inventor.
2, statistical result is in Table 1
Table 1
Capsule pill sales volume (box) Liquid medicine sales volume (box) Product sales volume (box) of the present invention
Big pharmacy, swallow wedding hall 172 18 980
The raw big pharmacy of hall 156 11 863
Vertical strong big pharmacy 106 8 1002
Table 1 is this it appears that sales volume of the present invention is significantly more than traditional Chinese medicine, and investigation also finds that capsule pill class mostly is old people and buys, and product of the present invention is mainly Yong adult people and buys.
Within 5 months post sales, having done satisfaction investigation, statistical result is table 2 such as.
Table 2
Easy to use, be easy to carry Use rear instant effect Good results degree
Capsule pill 19% 15% 30%
Liquid medicine 3% 22% 23%
Product of the present invention 78% 63% 47%
As can be seen from Table 2, product of the present invention using, carry, be substantially better than conventional medicament in instant effect, in therapeutic effect, be also better than conventional medicament.
3, discuss
Seriousness acute and chronic traumatic injury advises that timely medical check is in order to avoid delaying treatment, advises that oral capsule pill adds product external application of the present invention during recuperating, and slows down pain and accelerates treatment；Damage not under serious conditions, directly smear this product.

Claims (1)

1. the preparation method for treating the Chinese medicinal ointment of acute and chronic traumatic injury, it is characterised in that carry out according to following steps:
1), product A is made: joining in container by Radix Angelicae Sinensis, Flos Carthami, Sanguis Draxonis, Olibanum, Myrrha, catechu and water according to certain mass ratio, decoct 20～120min, cold filtration under 80～100 DEG C of conditions, the filtrate obtained after filtration is product A；
And make polymer substance solution: joining in container by polymer substance and distilled water according to certain mass ratio, heating is to 80～100 DEG C, and stirring, to being completely dissolved, obtains polymer substance solution；
2), by product A, polymer substance solution, wetting agent, natural freshener and wetting and penetrating agent according to certain mass than mix homogeneously, be concentrated into paste, obtain the Chinese medicinal ointment for treating acute and chronic traumatic injury；
The mass ratio of described Radix Angelicae Sinensis, Flos Carthami, Sanguis Draxonis, Olibanum, Myrrha, catechu and water is 1～20:1～20:1～20:1～20:1～20:1～20:100～1000;
The mass ratio of described polymer substance and distilled water is 5～15:85～95；The mass ratio of described product A, polymer substance solution, wetting agent, natural freshener and wetting and penetrating agent is 45～75:5～35:0.5～10:0.5～10:0.5～10；
Described polymer substance is the two or more of a kind of or arbitrary proportion in polyacrylamide, sodium polyacrylate, sodium alginate, guar gum, sodium carboxymethyl cellulose and polyvinyl alcohol；Described wetting agent is the two or more of a kind of or arbitrary proportion in glycerol, propylene glycol and sorbitol；Described natural freshener is the two or more of a kind of or arbitrary proportion in Oleum menthae, menthol and Borneolum Syntheticum；Described wetting and penetrating agent is the two or more of a kind of or arbitrary proportion in alkylphenol polyoxyethylene, Sorbitan fatty acid ester-20, Sorbitan fatty acid ester-30, Sorbitan fatty acid ester-80, polyoxyethylene 20 sorbitan monolaurate-20, polyoxyethylene 20 sorbitan monolaurate-40, polyoxyethylene 20 sorbitan monolaurate-60, polyoxyethylene 20 sorbitan monolaurate-80 and dimethicone.
CN201610191792.4A 2016-03-30 2016-03-30 Preparation method of traditional Chinese medicine ointment for treating acute or chronic traumatic injuries Withdrawn CN105796806A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110946557A (en) * 2019-11-11 2020-04-03 华中科技大学 Traumatic injury treatment is with wearable real-time supervision device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1391939A (en) * 2002-08-06 2003-01-22 马世荣 External medicine for curing traumatic injuries

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1391939A (en) * 2002-08-06 2003-01-22 马世荣 External medicine for curing traumatic injuries

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张萍等: "近五年中药巴布剂的研究进展", 《中国现代中药》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110946557A (en) * 2019-11-11 2020-04-03 华中科技大学 Traumatic injury treatment is with wearable real-time supervision device
CN110946557B (en) * 2019-11-11 2021-03-26 华中科技大学 Traumatic injury treatment is with wearable real-time supervision device

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Application publication date: 20160727