CN104688408A - Medical defervescence patch and preparation method thereof - Google Patents
Medical defervescence patch and preparation method thereof Download PDFInfo
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- CN104688408A CN104688408A CN201510108257.3A CN201510108257A CN104688408A CN 104688408 A CN104688408 A CN 104688408A CN 201510108257 A CN201510108257 A CN 201510108257A CN 104688408 A CN104688408 A CN 104688408A
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- medical defervescence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
Abstract
The invention discloses a medical defervescence patch and a preparation method thereof. The medical defervescence patch comprises a medical defervescence patch body composed of a backing layer, an adhesive layer and a screen membrane, wherein the screen membrane layer is arranged above the adhesive layer, the backing layer is arranged below adhesive layer, and the backing layer is made of a PU film. The invention also discloses a preparation method of the medical defervescence patch. The method includes the steps of uniformly mixing and stirring dihydroxyaluminum aminoacetate with a dispersant and a humectant, adding a cross-linking agent, an adhesion agent, a thickener, a temperature-sensitive color changing microcapsule, medical ethanol and the balance of purified water, adding peppermint essential oil, lemon essential oil and folium eucalypti essential oil in a cross-linking polymerization process of the above materials, uniformly dispersing and mixing into a polymer delivery material containing active ingredients, applying the material to an anti-adhesion layer to be made into attached preparation, and adhering the attached preparation to the PU film to obtain the medical defervescence patch. The PU film is non-toxic and harmless and has high water resistance and good moisture permeability. The medical defervescence patch is provided with temperature-sensitive ink for enabling a user to judge whether a fever is abated or not according to the color change on the medical defervescence patch, thereby being easy to operate.
Description
Technical field
The present invention relates to a kind of medical defervescence plaster used, also relate to a kind of medical defervescence plaster used preparation method.
Background technology
In daily life; people often can run into the heating that a variety of causes causes; especially fever caused by exogenous pathogens; carrying out Physical temperature-lowering is in time the measure first taked; the multiplex ethanol of Physical temperature-lowering is at place's rubbing bath such as patient back, face, abdominal part, axillary fossas; single cooling antipyretic effect is just played with ethanol cooling; fundamentally can not eliminate the cause of disease; in addition antipyretic analgesic can be taken; and medicine can bring very large toxic and side effects to human body, especially the special population such as anemia of pregnant woman, baby more should not take antibiotics.
Medical defervescence plaster used it belong to Physical temperature-lowering articles for use, be widely used in fever of children fever, pass the summer in a leisurely way and the situation such as work in hot environment.But current medical defervescence plaster used backing layer is made primarily of non-woven fabrics, and whether patient is brought down a fever do not show intuitively.
Summary of the invention
Whether the technical issues that need to address of the present invention are to provide a kind of medical defervescence plaster used, can decline according to the temperature of the change patient of medical defervescence plaster used upper color.
Present invention also offers a kind of medical defervescence plaster used preparation method.
The technical solution used in the present invention is: medical defervescence plaster used, comprise medical defervescence plaster used body, described medical defervescence plaster used body is made up of backing layer, gel layer and net barrier film, described net barrier film is positioned at the upper strata of gel layer, described backing layer is positioned at the lower floor of gel layer, described gel layer is Macromolecule glue-line, and described Macromolecule glue-line is made up of the raw material of following mass percent and proportioning thereof:
Macromolecule glue material 30-32%;
Dihydroxyaluminum aminoacetate 0.08-0.1%;
Mass concentration is the medical ethanol 1%-2% of 75%;
Peppermint essential oil 1%-2%;
Fructus Citri Limoniae quintessence oil 1%-1.5%;
Eucalyptus leaf essential oil 1%-1.5%;
Heat discoloration microcapsule 0.3%-0.5%;
Purified water adds to 100%;
Wherein, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, and described dispersant is sodium polyacrylate, described wetting agent is glycerol, described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone.
Described backing layer is made up of PU film.
Above-mentioned medical defervescence plaster used preparation method, comprise the following steps: be that the dispersant of 0.42-0.5% and the wetting agent mix homogeneously of 23%-24% stir 20min by mass percent in the dihydroxyaluminum aminoacetate of 0.08-0.1% and Macromolecule glue material, adding mass percent is more wherein 0.08-0.1% cross-linking agent, 4.5%-5.0% binder, 2%-2.4% thickening agent, 0.3%-0.5% heat discoloration microcapsule, 1%-2% mass concentration is the medical ethanol of 75% and the purified water of surplus, the material of above-mentioned mixing is carried out cross-linked polymeric, vacuum stirring 5-8 min, the Peppermint essential oil that mass percent is 1%-2% is added again in cross-linking polymerization process, the Fructus Citri Limoniae quintessence oil of 1%-1.5%, the eucalyptus leaf essential oil of 1%-1.5%, vacuum stirring 5 minutes in blender, the dispersed polymeric alloy membrane be mixed into containing active component of last above-mentioned material, polymeric alloy membrane is coated on adherent layer, make attached preparation, again attached preparation is affixed on PU film, medical defervescence plaster used.
In above-mentioned preparation method, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, described dispersant is sodium polyacrylate, described wetting agent is glycerol, described thickening agent is tartaric acid, described binder is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone.
Advantage of the present invention is: PU film is a kind of nontoxic environment-friendly materials, and its elasticity is good, slightly high, has and to have more splendid poisture-penetrability (human body antiperspirant gas can between thin film free penetrating) outside high water resistance, to human body skin without any injury.Adopt microcapsule technology to be applied to medical defervescence plaster used then for heat discoloration powder locks by filmogen, temperature is discharged by power conversion automatically more than 38 degrees Celsius, colloid variable color, absorbs head heat, makes patient temperature drop low.This is medical defervescence plaster usedly has temperature sensing ink, can according to the change of medical defervescence plaster used upper color, whether judges the decline of temperature, easy to operate.
Detailed description of the invention
In order to deepen the understanding of the present invention, below in conjunction with embodiment, the invention will be further described, and this embodiment only for explaining the present invention, does not form limiting the scope of the present invention.
Embodiment 1
Medical defervescence plaster used, comprise medical defervescence plaster used body, described medical defervescence plaster used body is made up of backing layer, gel layer and net barrier film, described net barrier film is positioned at the upper strata of gel layer, described backing layer is positioned at the lower floor of gel layer, described gel layer is Macromolecule glue-line, and described Macromolecule glue-line is made up of the raw material of following mass percent and proportioning thereof:
Macromolecule glue material 30%;
Dihydroxyaluminum aminoacetate 0.08%;
Mass concentration is the medical ethanol 1% of 75%;
Peppermint essential oil 1%;
Fructus Citri Limoniae quintessence oil 1%;
Eucalyptus leaf essential oil 1%
Heat discoloration microcapsule 0.3%
Add purified water to 100%.
Wherein, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, and described dispersant is sodium polyacrylate, and described wetting agent is glycerol, and described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidone.Described cross-linking agent is polyvinylpolypyrrolidone.Described backing layer is made up of PU film.
PU film replaces traditional non-woven fabrics, non-woven fabrics is originally opaque, color be cannot see by colloid, non-woven fabrics is replaced with PU film, PU film can be translucent, in colloid, add heat discoloration microcapsule, the change of colloid color can be seen through PU film, the situation of change of body temperature can be known intuitively.Because heat discoloration microcapsule comprises stealthy dyestuff, color forming agent and temperature control agent, select by different temperature control materials the colorant can producing different temperature range variable colors.
Embodiment 2
Medical defervescence plaster used, comprise medical defervescence plaster used body, described medical defervescence plaster used body is made up of backing layer, gel layer and net barrier film, described net barrier film is positioned at the upper strata of gel layer, described backing layer is positioned at the lower floor of gel layer, described gel layer is Macromolecule glue-line, and described Macromolecule glue-line is made up of the raw material of following mass percent and proportioning thereof:
Macromolecule glue material 32%;
Dihydroxyaluminum aminoacetate 0.1%;
Mass concentration is the medical ethanol 2% of 75%;
Peppermint essential oil 2%;
Fructus Citri Limoniae quintessence oil 1.5%;
Eucalyptus leaf essential oil 1.5%
Heat discoloration microcapsule 0.5%
Add purified water to 100%.
Wherein, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, and described dispersant is sodium polyacrylate, described wetting agent is glycerol, described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone.
Described backing layer is made up of PU film.
Embodiment 3
Medical defervescence plaster used, comprise medical defervescence plaster used body, described medical defervescence plaster used body is made up of backing layer, gel layer and net barrier film, described net barrier film is positioned at the upper strata of gel layer, described backing layer is positioned at the lower floor of gel layer, described gel layer is Macromolecule glue-line, and described Macromolecule glue-line is made up of the raw material of following mass percent and proportioning thereof:
Macromolecule glue material 31%;
Dihydroxyaluminum aminoacetate 0.09%;
Mass concentration is the medical ethanol 1.5% of 75%;
Peppermint essential oil 1.5%;
Fructus Citri Limoniae quintessence oil 1.3%;
Eucalyptus leaf essential oil 1.3%
Heat discoloration microcapsule 0.4%
Add purified water to 100%.
Wherein, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, and described dispersant is sodium polyacrylate, described wetting agent is glycerol, described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone.
Described backing layer is made up of PU film.
Embodiment 4
A kind of medical defervescence plaster used preparation method, comprise the following steps: be that the dispersant of 0.42% and the wetting agent mix homogeneously of 23% stir 20min by mass percent in the dihydroxyaluminum aminoacetate of 0.08% and Macromolecule glue material, adding mass percentage is more wherein 0.08% cross-linking agent, 4.5% binder, 2% thickening agent, 0.3% heat discoloration microcapsule, 1% mass concentration is the medical ethanol of 75% and the purified water of surplus, the material of above-mentioned mixing is carried out cross-linked polymeric, vacuum stirring 5-8 min, the Peppermint essential oil that mass percentage is 1% is added again in cross-linking polymerization process, the Fructus Citri Limoniae quintessence oil of 1%, the eucalyptus leaf essential oil of 1%, vacuum stirring 5 minutes in blender, the dispersed polymeric alloy membrane be mixed into containing active component of last above-mentioned material, polymeric alloy membrane is coated on adherent layer, make attached preparation, again attached preparation is affixed on PU film, medical defervescence plaster used.
In above-mentioned preparation method, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, described dispersant is sodium polyacrylate, described wetting agent is glycerol, described thickening agent is tartaric acid, described binder is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone.
Embodiment 5
A kind of medical defervescence plaster used preparation method, comprise the following steps: be that the dispersant of 0.5% and the wetting agent mix homogeneously of 24% stir 20min by mass percent in the dihydroxyaluminum aminoacetate of 0.1% and Macromolecule glue material, adding mass percentage is more wherein 0.1% cross-linking agent, 5% binder, 2.4% thickening agent, 0.5% heat discoloration microcapsule, 2% mass concentration is the medical ethanol of 75% and the purified water of surplus, the material of above-mentioned mixing is carried out cross-linked polymeric, vacuum stirring 5-8 min, the Peppermint essential oil that mass percentage is 2% is added again in cross-linking polymerization process, the Fructus Citri Limoniae quintessence oil of 1.5%, the eucalyptus leaf essential oil of 1.5%, vacuum stirring 5 minutes in blender, the dispersed polymeric alloy membrane be mixed into containing active component of last above-mentioned material, polymeric alloy membrane is coated on adherent layer, make attached preparation, again attached preparation is affixed on PU film, medical defervescence plaster used.
In above-mentioned preparation method, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, described dispersant is sodium polyacrylate, described wetting agent is glycerol, described thickening agent is tartaric acid, described binder is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone.
Embodiment 6
A kind of medical defervescence plaster used preparation method, comprise the following steps: be that the dispersant of 0.45% and the wetting agent mix homogeneously of 24% stir 20min by mass percent in the dihydroxyaluminum aminoacetate of 0.09% and Macromolecule glue material, adding mass percentage is more wherein 0.09% cross-linking agent, 4.8% binder, 2.3% thickening agent, 0.4% heat discoloration microcapsule, 1.5% mass concentration is the medical ethanol of 75% and the purified water of surplus, the material of above-mentioned mixing is carried out cross-linked polymeric, vacuum stirring 5-8 min, the Peppermint essential oil that mass percentage is 1.5% is added again in cross-linking polymerization process, the Fructus Citri Limoniae quintessence oil of 1.3%, the eucalyptus leaf essential oil of 1.3%, vacuum stirring 5 minutes in blender, the dispersed polymeric alloy membrane be mixed into containing active component of last above-mentioned material, polymeric alloy membrane is coated on adherent layer, make attached preparation, again attached preparation is affixed on PU film, medical defervescence plaster used.
In above-mentioned preparation method, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, described dispersant is sodium polyacrylate, described wetting agent is glycerol, described thickening agent is tartaric acid, described binder is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone.
Claims (4)
1. medical defervescence plaster used, comprise medical defervescence plaster used body, it is characterized in that: described medical defervescence plaster used body is made up of backing layer, gel layer and net barrier film, described net barrier film is positioned at the upper strata of gel layer, described backing layer is positioned at the lower floor of gel layer, described gel layer is Macromolecule glue-line, and described Macromolecule glue-line is made up of the raw material of following mass percent and proportioning thereof:
Macromolecule glue material 30-32%;
Dihydroxyaluminum aminoacetate 0.08-0.1%;
Mass concentration is the medical ethanol 1%-2% of 75%;
Peppermint essential oil 1%-2%;
Fructus Citri Limoniae quintessence oil 1%-1.5%;
Eucalyptus leaf essential oil 1%-1.5%;
Heat discoloration microcapsule 0.3%-0.5%;
Purified water adds to 100%;
Wherein, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, and described dispersant is sodium polyacrylate, described wetting agent is glycerol, described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone.
2. according to claim 1 medical defervescence plaster used, it is characterized in that: described backing layer is made up of PU film.
3. a medical defervescence plaster used preparation method as claimed in claim 1, it is characterized in that, comprise the following steps: be that the dispersant of 0.42%-0.5% and the wetting agent mix homogeneously of 23%-24% stir 20min by mass percent in the dihydroxyaluminum aminoacetate of 0.08%-0.1% and Macromolecule glue material, adding mass percent is more wherein 0.08%-0.1% cross-linking agent, 4.5%-5.0% binder, 2%-2.4% thickening agent, 0.3%-0.5% heat discoloration microcapsule, 1%-2% mass concentration is the medical ethanol of 75% and the purified water of surplus, the material of above-mentioned mixing is carried out cross-linked polymeric, vacuum stirring 5-8 min, the Peppermint essential oil that mass percent is 1%-2% is added again in cross-linking polymerization process, the Fructus Citri Limoniae quintessence oil of 1%-1.5%, the eucalyptus leaf essential oil of 1%-1.5%, vacuum stirring 5 minutes in blender, the dispersed polymeric alloy membrane be mixed into containing active component of last above-mentioned material, polymeric alloy membrane is coated on net barrier film, make attached preparation, again attached preparation is affixed on PU film, medical defervescence plaster used.
4. a medical defervescence plaster used preparation method as claimed in claim 3, it is characterized in that, described Macromolecule glue material comprises dispersant, wetting agent, thickening agent, binder and cross-linking agent, described dispersant is sodium polyacrylate, described wetting agent is glycerol, described thickening agent is tartaric acid, and described binder is polyvinylpyrrolidone, and described cross-linking agent is polyvinylpolypyrrolidone.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510108257.3A CN104688408B (en) | 2015-03-12 | 2015-03-12 | Medical defervescence plaster used and preparation method thereof |
| PCT/CN2015/099072 WO2016141755A1 (en) | 2015-03-12 | 2015-12-25 | Medical defervescence patch and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510108257.3A CN104688408B (en) | 2015-03-12 | 2015-03-12 | Medical defervescence plaster used and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104688408A true CN104688408A (en) | 2015-06-10 |
| CN104688408B CN104688408B (en) | 2016-08-31 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510108257.3A Active CN104688408B (en) | 2015-03-12 | 2015-03-12 | Medical defervescence plaster used and preparation method thereof |
Country Status (2)
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| CN (1) | CN104688408B (en) |
| WO (1) | WO2016141755A1 (en) |
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| CN105147443A (en) * | 2015-09-24 | 2015-12-16 | 江门市新时代外用制剂有限公司 | Thermochromic fever cooling patch and manufacturing method thereof |
| CN105213087A (en) * | 2015-09-24 | 2016-01-06 | 江门市新时代外用制剂有限公司 | One is defervescence plaster used and preparation method thereof |
| WO2016141755A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Medical defervescence patch and preparation method therefor |
| WO2016141756A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Headache-relieving patch and preparation method therefor |
| CN107647962A (en) * | 2017-09-30 | 2018-02-02 | 浙江三赢新材料有限公司 | Cold and hot compress product with temperature warning function |
| CN108553215A (en) * | 2018-07-03 | 2018-09-21 | 安徽省纳胜化工有限公司 | A kind of Reversible thermochromic of transparent PU Compound Fabrics is defervescence plaster used |
| CN109124862A (en) * | 2018-07-12 | 2019-01-04 | 广州馥邦科技应用有限公司 | A kind of control-release long-acting is defervescence plaster used and preparation method thereof |
| CN109498255A (en) * | 2018-12-18 | 2019-03-22 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | A kind of efficient heat transfer type is defervescence plaster used |
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| WO2016141755A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Medical defervescence patch and preparation method therefor |
| WO2016141756A1 (en) * | 2015-03-12 | 2016-09-15 | 施敬东 | Headache-relieving patch and preparation method therefor |
| CN105147443A (en) * | 2015-09-24 | 2015-12-16 | 江门市新时代外用制剂有限公司 | Thermochromic fever cooling patch and manufacturing method thereof |
| CN105213087A (en) * | 2015-09-24 | 2016-01-06 | 江门市新时代外用制剂有限公司 | One is defervescence plaster used and preparation method thereof |
| CN105147443B (en) * | 2015-09-24 | 2017-12-19 | 江门市新时代外用制剂有限公司 | A kind of heat discoloration is defervescence plaster used and preparation method thereof |
| CN107647962A (en) * | 2017-09-30 | 2018-02-02 | 浙江三赢新材料有限公司 | Cold and hot compress product with temperature warning function |
| CN107647962B (en) * | 2017-09-30 | 2022-05-13 | 浙江三赢新材料有限公司 | Cold and hot compress product with temperature warning function |
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| CN111588541A (en) * | 2020-04-28 | 2020-08-28 | 浙江理工大学 | Recyclable visual anti-counterfeiting physical cooling paste and preparation method thereof |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2016141755A1 (en) | 2016-09-15 |
| CN104688408B (en) | 2016-08-31 |
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