CN102973538A - Cataplasm substrate and application thereof - Google Patents
Cataplasm substrate and application thereof Download PDFInfo
- Publication number
- CN102973538A CN102973538A CN2012105523660A CN201210552366A CN102973538A CN 102973538 A CN102973538 A CN 102973538A CN 2012105523660 A CN2012105523660 A CN 2012105523660A CN 201210552366 A CN201210552366 A CN 201210552366A CN 102973538 A CN102973538 A CN 102973538A
- Authority
- CN
- China
- Prior art keywords
- water
- mixing
- stirring
- acid
- purified water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to a cataplasm substrate and application thereof. The cataplasm substrate can effectively solve the problems of insufficient viscoelasticity, bad adhesion and easiness for adhesion dropping in the prior art. The cataplasm substrate is prepared from the following materials in percentage by weight: 4%-8% of polyacrylic acid, 5%-10% of tackifiers, 25%-35% of humectants, 40%-65% of purified water, 0.05%-0.5% of cross-linking agents, 0.05%-0.2% of cross-linking regulating agents, 0.1%-0.5% of pH regulating agents, 0.5%-10% of filling agents and 0.01%-0.5% of antiseptics and through the following steps of: firstly dissolving the tackifiers by using the purified water, then adding the pH regulating agents and the antiseptics and mixing and stirring to obtain a uniform water phase for standby; then mixing the polyacrylic acid, the humectants, the cross-linking agents, the cross-linking regulating agents and the filling agents, and stirring to obtain a uniform oil phase; and then mixing the water phase and the oil phase together, uniformly stirring to obtain the cataplasm substrate. The cataplasm substrate disclosed by the invention has the advantages of good dependence on skin, no stimulation, quick medical effect, repeated viscosity, moisture preservation and air ventilation and good using effect and is an innovation of the cataplasm substrate.
Description
Technical field
The present invention relates to medicine, particularly a kind of catablasm base material and application thereof.
Background technology
Cataplasma refer to medicinal substances extract, medical material or and chemicals and suitable hydrophilic matrix mixing after, coat the emplastrum of making on the back lining materials.As far back as take the lead in invention cataplasma type and release correlated product of Japanese Saitama Daiichi Pharmaceutical Co., Ltd. in 1963.1999, " the compound recipe cercis disappears and hinders cream " obtained domestic first cataplasma New Drug Certificate.
Compare with traditional plaster, cataplasma has that drug loading is large, transdermal effect good, bioavailability is high, the dose composition is controlled, moisture retention is strong, good with the compatibility of skin, without advantages such as organic solvent pollutions, in addition, the moisturizing compositions such as catablasm base material is moisture, glycerol, sorbitol have skin care, promote skin hydration, be beneficial to the active component percutaneous and absorb, very high at tractions such as Japan, Korea S, Taiwan.
Simultaneously cataplasma exists also that viscoelasticity is inadequate, applicating property is bad, sticks the shortcoming such as easy landing.And domestic cataplasma production do not have a kind of generally acknowledged comparatively ripe preparation technology, and the production equipment different manufacturers is different, and properties of product differ greatly.Therefore, the improvement of cataplasma is the problem of needing at present solution badly.
Summary of the invention
For above-mentioned situation, be to solve the defective of prior art, the present invention's purpose just provides a kind of catablasm base material and application thereof, can solve effectively that the prior art viscoelasticity is inadequate, applicating property is bad, stick the problem of easy landing.
The technical scheme that the present invention solves is, by following weight percent meter: polyacrylic acid 4～8%, viscosifier 5～10%, wetting agent 25～35%, purified water 40～65%, cross-linking agent 0.05～0.5%, cross-linking regulator 0.05～0.2%, pH adjusting agent 0.1～0.5%, filler 0.5～10% and antiseptic 0.01～0.5% are made, wherein, first viscosifier, purified water, pH adjusting agent and antiseptic mixing and stirring are become water, for subsequent use; Again polyacrylic acid, wetting agent, cross-linking agent, cross-linking regulator and filler mixing and stirring are become oil phase, then above-mentioned water and oil phase are mixed and stir, and get final product; Described viscosifier are one or more compositions of sodium carboxymethyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol, gelatin, carbomer, polyethylene glycol oxide, acrylic acid grafted starch; Described wetting agent is one or more compositions of glycerol, sorbitol, propylene glycol; Described purified water is the medicinal water that drinking water makes through the way of distillation, ion exchange, hyperfiltration; Described cross-linking agent is one or more compositions of dihydroxyaluminum aminoacetate, aluminium hydroxide, aluminum chloride; Described cross-linking regulator is one or more compositions of ethylenediaminetetraacetic acid (EDTA), disodiumedetate (EDTA-2NA), tetrasodium ethylenediamine tetraacetate (EDTA-4NA); Described is one or both compositions of tartaric acid, citric acid for pH adjusting agent; Described filler is one or more compositions of polyvinylpolypyrrolidone, sodium carboxymethyl cellulose, silicon dioxide, titanium dioxide; Described antiseptic is one or more the compositions of Gloriosa saperba L. pellet, methyl hydroxybenzoate, ethyl hydroxybenzoate, germall BP.
Also can add in this substrate and to account for substrate weight: Oleum Ricini 0.1～1.0% is as plasticizer, and edible essence 0.01～1.0% is as correctives, and polyoxyethylene sorbitan monoleate 0.1～1.0% is as emulsifying agent, and food coloring 0.01～1.0% is as toner.
Catablasm base material of the present invention is for the preparation of cataplasma, and preparation method is: add active constituents of medicine 5～30g with every 100g catablasm base material and pour in the vacuum stirring tank, and evacuation, then first rapid dispersion at the uniform velocity is stirred to colloid and is uniformly dispersed, and get final product; Described active constituents of medicine is one or more compositions of medicine, Chinese medicine extract and volatile medicine.
Described medicine is one or more compositions of diphhydramine hydrochloride, alpha-tocopherol acetate, thymol, indomethacin, ketoprofen, Tulobuterol, flurbiprofen; Described Chinese medicine extract is one or more compositions of capsicum oleoresin, affection of dampness extractum, liguidamber resinoid, Fructus Capsici fluidextract, Semen daturae fluid extract; Described volatile medicine is one or more compositions of Camphora, Borneolum Syntheticum, Mentholum, Oleum menthae, methyl salicylate, glycol salicylate.
The present invention is good to the skin compliance, and is non-stimulated, and the property of medicine is rapid-action, and moisturizing is ventilative, and result of use is good, is the innovation on the catablasm base material.
The specific embodiment
Below in conjunction with embodiment the specific embodiment of the present invention is described in further detail.
Embodiment 1
The present invention in the specific implementation, can be by following weight percent meter: polyacrylic acid 4.2%, sodium carboxymethyl cellulose 4%, polyvinylpyrrolidone 4%, polyethylene glycol oxide 1.5%, glycerol 26%, purified water 58.5%, dihydroxyaluminum aminoacetate 0.1%, disodiumedetate 0.15%, tartaric acid 0.15%, polyvinylpolypyrrolidone 1% and germall BP 0.4% make, wherein, (1) first sodium carboxymethyl cellulose, polyvinylpyrrolidone and polyethylene glycol oxide are added heating for dissolving in the purified water, add again tartaric acid and become water with germall BP mixing and stirring, for subsequent use; (2) glycerol, polyacrylic acid, dihydroxyaluminum aminoacetate, disodiumedetate and polyvinylpolypyrrolidone mixing and stirring are become oil phase, water and oil phase are mixed, stir, and get final product.
Also can be by weighing scale: polyacrylic acid 420g, sodium carboxymethyl cellulose 400g, PVP 0g, polyethylene glycol oxide 150g, glycerol 2600g, purified water 5850g, dihydroxyaluminum aminoacetate 10g, disodiumedetate 15g, tartaric acid 15g, polyvinylpolypyrrolidone 100g and germall BP 40g make.
Embodiment 2
The present invention in the specific implementation, by following weight percent meter: polyacrylic acid 4.8%, sodium carboxymethyl cellulose 2.5%, polyvinylpyrrolidone 4%, glycerol 30%, purified water 55.79%, dihydroxyaluminum aminoacetate 0.06%, aluminium hydroxide 0.4%, ethylenediaminetetraacetic acid 0.1%, tartaric acid 0.2%, silicon dioxide 2% and Gloriosa saperba L. pellet 0.15% are made, wherein, (1) first sodium carboxymethyl cellulose and polyvinylpyrrolidone are added heating for dissolving in the purified water, add again tartaric acid and become water with the red mixing and stirring of Gloriosa saperba L., for subsequent use; (2) glycerol, polyacrylic acid, dihydroxyaluminum aminoacetate, aluminium hydroxide, ethylenediaminetetraacetic acid and silicon dioxide mixing and stirring are become oil phase, water and oil phase are mixed, stir, and get final product.
Also can be by weighing scale: the red 15g of polyacrylic acid 480g, sodium carboxymethyl cellulose 250g, PVP 0g, glycerol 3000g, purified water 5579g, dihydroxyaluminum aminoacetate 6g, aluminium hydroxide 40g, ethylenediaminetetraacetic acid 10g, tartaric acid 20g, silicon dioxide 200g and Gloriosa saperba L. makes.
Embodiment 3
The present invention in the specific implementation, by following weight percent meter: polyacrylic acid 8%, gelatin 3.2%, carbomer 2%, propylene glycol 30%, purified water 54.37%, aluminum chloride 0.3%, tetrasodium ethylenediamine tetraacetate 0.18%, citric acid 0.25%, sodium carboxymethyl cellulose 1.5% and methyl hydroxybenzoate 0.2% are made, wherein, (1) first gelatin and carbomer are added heating for dissolving in the purified water, add again citric acid, the methyl hydroxybenzoate mixing and stirring becomes water, and is for subsequent use; (2) propylene glycol, polyacrylic acid, aluminum chloride, tetrasodium ethylenediamine tetraacetate and sodium carboxymethyl cellulose mixing and stirring are become oil phase, water and oil phase are mixed, stir, and get final product.
Also can be by weighing scale: polyacrylic acid 800g, gelatin 320g, carbomer 200g, propylene glycol 3000g, purified water 5437g, aluminum chloride 30g, tetrasodium ethylenediamine tetraacetate 18g, citric acid 25g, sodium carboxymethyl cellulose 150g and methyl hydroxybenzoate 20g make.
Embodiment 4
The present invention in the specific implementation, by following weight percent meter: polyacrylic acid 5.8%, sodium carboxymethyl cellulose 5%, polyethylene glycol oxide 1%, acrylic acid grafted starch 3%, sorbitol 34%, purified water 47.87%, dihydroxyaluminum aminoacetate 0.08%, disodiumedetate 0.15%, citric acid 0.3%, titanium dioxide 2.5% and ethyl hydroxybenzoate 0.3% are made, wherein, (1) first sodium carboxymethyl cellulose, polyethylene glycol oxide and acrylic acid grafted starch are added heating for dissolving in the purified water, add again citric acid, the ethyl hydroxybenzoate mixing and stirring becomes water, and is for subsequent use; (2) sorbitol, polyacrylic acid, dihydroxyaluminum aminoacetate, disodiumedetate and titanium dioxide mixing and stirring are become oil phase, water and oil phase are mixed, stir, and get final product.
Also can be by weighing scale: polyacrylic acid 580g, sodium carboxymethyl cellulose 500g, polyethylene glycol oxide 100g, acrylic acid grafted starch 300g, sorbitol 3400g, purified water 4787g, dihydroxyaluminum aminoacetate 8g, disodiumedetate 15g, citric acid 30g, titanium dioxide 250g and ethyl hydroxybenzoate 30g make.
The cataplasma of the present invention's preparation, adopt the mode of pair roller squeezing and coating and secondary coating, effectively avoided the generation of bubble in the coating process, the back lining materials that uses is the bidirectional elastic non-woven fabrics, stick comfortable and be adapted to the joint and the larger position of quantity of motion, have good shrinkage, use comfort and convenient.
Performance: outward appearance: this product should be coated with evenly, and the cream face is bright and clean, and color and luster is consistent, without taking off cream, losing glutinous phenomenon; The backing face should smooth, clean, nothing leakage cream phenomenon.
Initial bonding strength, peel strength: all with reference to 2010 " an appendix XII of Chinese pharmacopoeia E emplastrum adhesion algoscopy is carried out, and the results are shown in following table:
Heat resistant test: get 2 of test samples, remove the lid lining, 60 ℃ of heating 2 hours, after letting cool, the cream back side should be without the oil impregnate phenomenon; The cream face is glossy, touches examination with finger and still has stickiness.
Low temperature resistant test: 2 of sample thiefs, put in-1 ℃ ± 1 ℃ the calorstat, keep taking out behind the 30min, gel should not freeze.
Breathability: under the pressure reduction condition of regulation, measure vertical air flow rate by the given area of sample in the certain hour, calculate air penetrability.R=
(mm/s)
In the formula: q
v-mean air flow amount, dm
3/ min (L/min);
A-test area, cm2;
167-be converted into the conversion coefficient of mm/s by dm3/min * cm2;
Stability: at 40 ℃ ± 2 ℃, accelerate June, stable performance under relative humidity 75% ± 5% condition.
Following table is the cataplasma for preparing of the present invention and the comparison of commercial like product:
Relatively found by upper table:
1. the cataplasma of the present invention's preparation is compared with the commercial like product, cream and inharmonious situation do not occur taking off, and commercially available portioned product has cream and the less situation of viscosity of taking off.
2. the cataplasma of the present invention preparation is compared with the commercial like product, has good initial bonding strength and the stronger effect of peeling off, and this is outstanding feature of the present invention.
3. the cataplasma of the present invention's preparation is compared with the commercial like product, has preferably cold tolerance.
4. the cataplasma of the present invention's preparation is compared with the commercial like product, has higher drug loading and better therapeutic effect.
5. the cataplasma of the present invention's preparation is compared with the commercial like product, adopts the bidirectional elastic non-woven fabrics with good permeability, has good breathability, is particularly suitable for joint and activity sticking than large part.
6. the cataplasma of the present invention's preparation is compared with the commercial like product, has better stability, and sample accelerates 6 months normally, meets stable guideline requirement.
Can find out more than comprehensive, the cataplasma of the present invention's preparation can effectively solve the weak problem of viscosity of the existing commercially available cataplasma product of part, can well increase the denseness of colloid and the viscosity of colloid, improve curative effect, good to the skin compliance, the property of medicine is rapid-action, can repeatedly paste, moisturizing is ventilative, and result of use is good.
Claims (7)
1. catablasm base material, it is characterized in that, by following weight percent meter: polyacrylic acid 4～8%, viscosifier 5～10%, wetting agent 25～35%, purified water 40～65%, cross-linking agent 0.05～0.5%, cross-linking regulator 0.05～0.2%, pH adjusting agent 0.1～0.5%, filler 0.5～10% and antiseptic 0.01～0.5% are made, wherein, first viscosifier are dissolved with purified water, add again pH adjusting agent and become water with the antiseptic mixing and stirring, for subsequent use; Again polyacrylic acid, wetting agent, cross-linking agent, cross-linking regulator and filler mixing and stirring are become oil phase, then above-mentioned water and oil phase are mixed, stir, and get final product; Described viscosifier are one or more compositions of sodium carboxymethyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol, gelatin, carbomer, polyethylene glycol oxide, acrylic acid grafted starch; Described wetting agent is one or more compositions of glycerol, sorbitol, propylene glycol; Described purified water is the medicinal water that drinking water makes through the way of distillation, ion exchange, hyperfiltration; Described cross-linking agent is one or more compositions of dihydroxyaluminum aminoacetate, aluminium hydroxide, aluminum chloride; Described cross-linking regulator is one or more compositions of ethylenediaminetetraacetic acid, disodiumedetate, tetrasodium ethylenediamine tetraacetate; Described is one or both compositions of tartaric acid, citric acid for pH adjusting agent; Described filler is one or more compositions of polyvinylpolypyrrolidone, sodium carboxymethyl cellulose, silicon dioxide, titanium dioxide; Described antiseptic is one or more the compositions of Gloriosa saperba L. pellet, methyl hydroxybenzoate, ethyl hydroxybenzoate, germall BP.
2. catablasm base material according to claim 1, it is characterized in that, by following weight percent meter: polyacrylic acid 4.2%, sodium carboxymethyl cellulose 4%, polyvinylpyrrolidone 4%, polyethylene glycol oxide 1.5%, glycerol 26%, purified water 58.5%, dihydroxyaluminum aminoacetate 0.1%, disodiumedetate 0.15%, tartaric acid 0.15%, polyvinylpolypyrrolidone 1% and germall BP 0.4% make, wherein, (1) first with sodium carboxymethyl cellulose, polyvinylpyrrolidone and polyethylene glycol oxide add heating for dissolving in the purified water, add again tartaric acid and become water with germall BP mixing and stirring, for subsequent use; (2) glycerol, polyacrylic acid, dihydroxyaluminum aminoacetate, disodiumedetate and polyvinylpolypyrrolidone mixing and stirring are become oil phase, water and oil phase are mixed, stir, and get final product.
3. catablasm base material according to claim 1, it is characterized in that, by following weight percent meter: polyacrylic acid 4.8%, sodium carboxymethyl cellulose 2.5%, polyvinylpyrrolidone 4%, glycerol 30%, purified water 55.79%, dihydroxyaluminum aminoacetate 0.06%, aluminium hydroxide 0.4%, ethylenediaminetetraacetic acid 0.1%, tartaric acid 0.2%, silicon dioxide 2% and Gloriosa saperba L. pellet 0.15% are made, wherein, (1) first sodium carboxymethyl cellulose and polyvinylpyrrolidone are added heating for dissolving in the purified water, add again tartaric acid and become water with the red mixing and stirring of Gloriosa saperba L., for subsequent use; (2) glycerol, polyacrylic acid, dihydroxyaluminum aminoacetate, aluminium hydroxide, ethylenediaminetetraacetic acid and silicon dioxide mixing and stirring are become oil phase, water and oil phase are mixed, stir, and get final product.
4. catablasm base material according to claim 1, it is characterized in that, by following weight percent meter: polyacrylic acid 8%, gelatin 3.2%, carbomer 2%, propylene glycol 30%, purified water 54.37%, aluminum chloride 0.3%, tetrasodium ethylenediamine tetraacetate 0.18%, citric acid 0.25%, sodium carboxymethyl cellulose 1.5% and methyl hydroxybenzoate 0.2% are made, wherein, (1) first gelatin and carbomer are added heating for dissolving in the purified water, add again citric acid, the methyl hydroxybenzoate mixing and stirring becomes water, and is for subsequent use; (2) propylene glycol, polyacrylic acid, aluminum chloride, tetrasodium ethylenediamine tetraacetate and sodium carboxymethyl cellulose mixing and stirring are become oil phase, water and oil phase are mixed, stir, and get final product.
5. catablasm base material according to claim 1, it is characterized in that, by following weight percent meter: polyacrylic acid 5.8%, sodium carboxymethyl cellulose 5%, polyethylene glycol oxide 1%, acrylic acid grafted starch 3%, sorbitol 34%, purified water 47.87%, dihydroxyaluminum aminoacetate 0.08%, disodiumedetate 0.15%, citric acid 0.3%, titanium dioxide 2.5% and ethyl hydroxybenzoate 0.3% made, wherein, (1) first with sodium carboxymethyl cellulose, polyethylene glycol oxide and acrylic acid grafted starch add heating for dissolving in the purified water, add again citric acid, the ethyl hydroxybenzoate mixing and stirring becomes water, and is for subsequent use; (2) sorbitol, polyacrylic acid, dihydroxyaluminum aminoacetate, disodiumedetate and titanium dioxide mixing and stirring are become oil phase, water and oil phase are mixed, stir, and get final product.
6. each described catablasm base material according to claim 1 and 2-5, it is characterized in that, also can add in this substrate and to account for substrate weight: Oleum Ricini 0.1～1.0% is as plasticizer, edible essence 0.01～1.0% is as correctives, polyoxyethylene sorbitan monoleate 0.1～1.0% is as emulsifying agent, and food coloring 0.01～1.0% is as toner.
7. the application of each described catablasm base material of claim 1 or 2-6 in the preparation cataplasma.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210552366.0A CN102973538B (en) | 2012-12-19 | 2012-12-19 | Cataplasm substrate and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210552366.0A CN102973538B (en) | 2012-12-19 | 2012-12-19 | Cataplasm substrate and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102973538A true CN102973538A (en) | 2013-03-20 |
| CN102973538B CN102973538B (en) | 2014-07-16 |
Family
ID=47848075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210552366.0A Active CN102973538B (en) | 2012-12-19 | 2012-12-19 | Cataplasm substrate and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102973538B (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394116A (en) * | 2013-08-21 | 2013-11-20 | 彭长生 | Hydrogel dressing capable of promoting wound healing and preparation method thereof |
| CN104491748A (en) * | 2015-01-06 | 2015-04-08 | 王芬 | Traditional Chinese medicine acupoint paste for treating dysmenorrhea and preparation and application method thereof |
| CN104547797A (en) * | 2014-09-23 | 2015-04-29 | 苏州市天灵中药饮片有限公司 | Dampness-affected analgesic cataplasm and preparation method thereof |
| CN104666652A (en) * | 2015-02-25 | 2015-06-03 | 吴凰 | Ointment with effects of promoting qi and activating blood circulation as well as promoting reunion of fractured bones and tendons |
| CN105963678A (en) * | 2016-05-17 | 2016-09-28 | 莆田学院附属医院 | Cyclosporine A micro-emulsion cataplasm eye patch and preparation method thereof |
| CN106822065A (en) * | 2016-12-06 | 2017-06-13 | 北京茗泽中和药物研究有限公司 | A kind of flurbiprofen cataplasms |
| CN104174007B (en) * | 2014-09-18 | 2018-05-08 | 北京中医药大学 | A kind of Traditional Chinese medicinal composition plaster agent for treating asthma |
| CN108704162A (en) * | 2018-08-08 | 2018-10-26 | 中国科学院长春应用化学研究所 | A kind of water suction dressing and preparation method thereof |
| CN110946846A (en) * | 2018-09-27 | 2020-04-03 | 湖南九典制药股份有限公司 | Loxoprofen sodium gel cream matrix without transdermal penetration enhancer and preparation method thereof |
| CN111789832A (en) * | 2019-08-19 | 2020-10-20 | 湖南九典制药股份有限公司 | Deketoprofen trometamol gel plaster and preparation method thereof |
| CN112245558A (en) * | 2020-10-30 | 2021-01-22 | 河南羚锐制药股份有限公司 | A hydrogel carsickness patch containing ginger oil and dried ginger powder |
| CN113350317A (en) * | 2021-06-03 | 2021-09-07 | 湖北恩威药业有限公司 | Allergy-free, red-swelling-resistant and fast-permeation solid hydrogel plaster base material |
| CN116265026A (en) * | 2021-12-17 | 2023-06-20 | 汶川县人民医院 | Radix aucklandiae gel emplastrum |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998579A (en) * | 2007-01-04 | 2007-07-18 | 中国人民解放军第二军医大学 | Hydrophillia Babu agent for treating depression |
| CN101780169A (en) * | 2010-03-10 | 2010-07-21 | 广州白云山制药股份有限公司白云山何济公制药厂 | Traumatic injury analgesic cataplasm preparation and preparation method thereof |
| CN101843608A (en) * | 2010-06-04 | 2010-09-29 | 齐齐哈尔医学院 | Buboo preparation for treating cardiovascular diseases and preparation method thereof |
| CN102225096A (en) * | 2011-06-07 | 2011-10-26 | 西安交通大学 | Rumex acetosa linn cataplasm and preparation method thereof |
| CN102397443A (en) * | 2010-09-17 | 2012-04-04 | 复旦大学 | Stagnation eliminating and pain stopping babu paste for treating proliferation of mammary gland and preparation method thereof |
-
2012
- 2012-12-19 CN CN201210552366.0A patent/CN102973538B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100998579A (en) * | 2007-01-04 | 2007-07-18 | 中国人民解放军第二军医大学 | Hydrophillia Babu agent for treating depression |
| CN101780169A (en) * | 2010-03-10 | 2010-07-21 | 广州白云山制药股份有限公司白云山何济公制药厂 | Traumatic injury analgesic cataplasm preparation and preparation method thereof |
| CN101843608A (en) * | 2010-06-04 | 2010-09-29 | 齐齐哈尔医学院 | Buboo preparation for treating cardiovascular diseases and preparation method thereof |
| CN102397443A (en) * | 2010-09-17 | 2012-04-04 | 复旦大学 | Stagnation eliminating and pain stopping babu paste for treating proliferation of mammary gland and preparation method thereof |
| CN102225096A (en) * | 2011-06-07 | 2011-10-26 | 西安交通大学 | Rumex acetosa linn cataplasm and preparation method thereof |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394116A (en) * | 2013-08-21 | 2013-11-20 | 彭长生 | Hydrogel dressing capable of promoting wound healing and preparation method thereof |
| CN104174007B (en) * | 2014-09-18 | 2018-05-08 | 北京中医药大学 | A kind of Traditional Chinese medicinal composition plaster agent for treating asthma |
| CN104547797A (en) * | 2014-09-23 | 2015-04-29 | 苏州市天灵中药饮片有限公司 | Dampness-affected analgesic cataplasm and preparation method thereof |
| CN104491748A (en) * | 2015-01-06 | 2015-04-08 | 王芬 | Traditional Chinese medicine acupoint paste for treating dysmenorrhea and preparation and application method thereof |
| CN104666652A (en) * | 2015-02-25 | 2015-06-03 | 吴凰 | Ointment with effects of promoting qi and activating blood circulation as well as promoting reunion of fractured bones and tendons |
| CN105963678A (en) * | 2016-05-17 | 2016-09-28 | 莆田学院附属医院 | Cyclosporine A micro-emulsion cataplasm eye patch and preparation method thereof |
| CN106822065A (en) * | 2016-12-06 | 2017-06-13 | 北京茗泽中和药物研究有限公司 | A kind of flurbiprofen cataplasms |
| CN108704162A (en) * | 2018-08-08 | 2018-10-26 | 中国科学院长春应用化学研究所 | A kind of water suction dressing and preparation method thereof |
| CN110946846A (en) * | 2018-09-27 | 2020-04-03 | 湖南九典制药股份有限公司 | Loxoprofen sodium gel cream matrix without transdermal penetration enhancer and preparation method thereof |
| CN110946846B (en) * | 2018-09-27 | 2021-08-10 | 湖南九典制药股份有限公司 | Loxoprofen sodium gel cream matrix without transdermal penetration enhancer and preparation method thereof |
| CN111789832A (en) * | 2019-08-19 | 2020-10-20 | 湖南九典制药股份有限公司 | Deketoprofen trometamol gel plaster and preparation method thereof |
| CN112245558A (en) * | 2020-10-30 | 2021-01-22 | 河南羚锐制药股份有限公司 | A hydrogel carsickness patch containing ginger oil and dried ginger powder |
| CN113350317A (en) * | 2021-06-03 | 2021-09-07 | 湖北恩威药业有限公司 | Allergy-free, red-swelling-resistant and fast-permeation solid hydrogel plaster base material |
| CN116265026A (en) * | 2021-12-17 | 2023-06-20 | 汶川县人民医院 | Radix aucklandiae gel emplastrum |
| CN116265026B (en) * | 2021-12-17 | 2024-05-10 | 汶川县人民医院 | Radix aucklandiae gel emplastrum |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102973538B (en) | 2014-07-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102973538B (en) | Cataplasm substrate and application thereof | |
| WO2016141755A1 (en) | Medical defervescence patch and preparation method therefor | |
| CN102634307A (en) | Hot-melting pressure sensitive adhesive and preparation method thereof | |
| TWI753901B (en) | Germinated brown rice saccharomyces veronae fermented liquid | |
| WO2006070578A1 (en) | Band seal for hard capsule | |
| CN100450480C (en) | Aquogel type thiamazole plaster preparation | |
| CN105125525B (en) | It is a kind of efficiently defervescence plaster used and preparation method thereof | |
| CN106880623A (en) | One kind carries the special hot-fusible pressure-sensitive adhesive of medicine | |
| CN103768063B (en) | A kind of moxifloxacin hydrochloride medicinal composition and preparation method thereof | |
| CN102850710B (en) | Framework material for medical plaster and preparation method thereof | |
| CN106063798A (en) | A kind of film for treating oral ulcer and preparation method thereof | |
| CN101703751B (en) | Emplastrum for treating white-plus disease and preparation method thereof | |
| CN105943521A (en) | Diatomite carrying taxinol functional non-woven fabric core | |
| CN101612141B (en) | Buprenorphine patch | |
| CN100473397C (en) | 'Rukuaixiao' preparation for treating mammary disease and preparation process thereof | |
| CN102488901A (en) | Cataplasm substrate with high-drug-load characteristic, and preparation method thereof | |
| CN110090198B (en) | Slow-release type oral ulcer gel with biological adhesion and preparation method thereof | |
| CN106822065A (en) | A kind of flurbiprofen cataplasms | |
| CN102343111A (en) | Adhesive patch and patch preparation | |
| CN104435078A (en) | Composition as well as application and preparation thereof | |
| CN107998072A (en) | clotrimazole cream and preparation method thereof | |
| CN103301093A (en) | Testosterone transdermal absorbent patch | |
| CN113318055A (en) | Soft membrane powder for maintaining barrier, resisting inflammation and activating blood and preparation method thereof | |
| CN101785864A (en) | Post-crosslinking hydrophilic patch substrate and preparation method thereof | |
| CN101780057B (en) | Transdermic absorption patch |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP02 | Change in the address of a patent holder | ||
| CP02 | Change in the address of a patent holder |
Address after: 465550 No. 666 General Road, Xinxian County, Henan Province Patentee after: Henan Lingrui Pharmaceutical Co., Ltd. Address before: 465550 No. 232 Xiangyang Road, Xinxian County, Xinyang City, Henan Province Patentee before: Henan Lingrui Pharmaceutical Co., Ltd. |