CN109124862A - A kind of control-release long-acting is defervescence plaster used and preparation method thereof - Google Patents
A kind of control-release long-acting is defervescence plaster used and preparation method thereof Download PDFInfo
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- CN109124862A CN109124862A CN201810765972.8A CN201810765972A CN109124862A CN 109124862 A CN109124862 A CN 109124862A CN 201810765972 A CN201810765972 A CN 201810765972A CN 109124862 A CN109124862 A CN 109124862A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0059—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit
- A61F2007/0063—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit for cooling
- A61F2007/0068—Heating or cooling appliances for medical or therapeutic treatment of the human body with an open fluid circuit for cooling evaporating on the spot to be cooled
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0203—Cataplasms, poultices or compresses, characterised by their contents; Bags therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0244—Compresses or poultices for effecting heating or cooling with layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/02—Compresses or poultices for effecting heating or cooling
- A61F2007/0261—Compresses or poultices for effecting heating or cooling medicated
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Abstract
It is defervescence plaster used and preparation method thereof the invention belongs to defervescence plaster used technical field more particularly to a kind of control-release long-acting.The present invention provides a kind of control-release long-acting is defervescence plaster used, comprising: back sheet, hydrogel layer and the protective film layer set gradually；The hydrogel layer is dispersed with microcapsules, and the encapsulation has volatile essential oil；The microcapsules are hydrophily chitosan nano mcirocapsule.In the present invention, defervescence plaster used hydrogel layer is dispersed with microcapsules, encapsulation has volatile essential oil, volatile essential oil can be made slowly to volatilize, extend the duration of the defervescence plaster used effect of bringing down a fever, microcapsules are hydrophily chitosan nano mcirocapsule, when the defervescence plaster used use, patient temperature is higher, the speed that combination water in hydrogel layer is converted into Free water is faster, so that the volatile essential oil in hydrophily chitosan nano mcirocapsule discharges faster, and then make the defervescence plaster used temperature sensitivity for having quick response.
Description
Technical field
It is defervescence plaster used and preparation method thereof the invention belongs to defervescence plaster used technical field more particularly to a kind of control-release long-acting.
Background technique
The heat production of normal human and heat dissipation keep dynamic equilibrium, but under many disease events, because pyrogen and pyrogenicity because
Element induces body heat production and increases, radiates and reduce, and body temperature is caused to rise or cause to have a fever.Fever, fever are the common physiology of people
And pathological reaction.When organism fever, internal heat mainly is distributed by forms such as convection current, radiation and evaporations, meanwhile, hypothalamus
Heat-regulating centers is recycled by expansion blood vessel, quickening and the modes such as perspiration enhance body heat dissipation.Being worth noting is, body heat
It is quick scatter and disappear, often will appear it is secondary feel cold and the clinical symptoms such as muscle tremors, while inducing internal heat production and rising rapidly, and
Cause vicious circle.Prolonged hay fever easily causes convulsions and stupor, the baby especially not yet to reach maturity to immune system etc.
It influences even more serious, carries out cooling of bringing down a fever therefore, it is necessary to take timely measure.
Clinically mainly there are drug cooling and physical method to cool down the processing of fever, specific processing is according to the cause of disease and trouble
Person's constitution and the degree of heat determine.Wherein, drug cooling has many advantages, such as that effect is obvious, application method is simple.Drug cooling packet
The oral of antipyretic, intramuscular injection and infusion etc. are included, currently used antipyretic has aspirin, paracetamol, disappears
Scorching pain and brufen etc..In recent years, people very pay close attention to the adverse reaction of drug therapy, and the side effect of drug cooling is larger, especially
It is unsuitable for baby and brings down a fever.Also, some antipyretics are serious to the liver kidney of patient and gastral damage, and have many taboos
Disease, the patient with antipyretic allergies should disable such drug, and allergic constitution patient and liver function immunocompromised patients are applying
Also it answers prudent when antipyretic or is discontinued, in addition, some antipyretics should not be taken for a long time because having side effect.It is defended according to the world
Raw tissue advocate safely, effectively, the clinical application theory that has no toxic side effect, the pass that Applied Physics method cools down by people
Note.Traditional physical cooling method includes control room temperature, ice compress and alcohol bath, is widely used in clinic.Currently used for physics
The product of method cooling has an ice bag and liquid cooling bag etc., and traditional ice bag is usually plastic foil or waterproof cloth bag, and when use will be cold
Freeze block to be placed in sack, spreads on forehead or other positions.Liquid cooling bag closed usually in plastic material bag built-in ethyl alcohol,
The biggish liquid of the specific heat capacities such as propylene glycol is freezed in refrigerator using preposition, these cooling products are using preceding because needing precooling
The processes such as processing, therefore limit its use.
The product of physical method cooling is defervescence plaster used according to Transdermal absorption principle there are also defervescence plaster used, after moisture is transdermal, through steam
The physical process for changing heat absorption reaches the hypothermic effect of drop.Currently, defervescence plaster used based on hydrogel is mostly based on macromolecule
Hydrogel is substrate, and water and the addition of natural freshener and active material are prepared in hydrogel.In use, passing through moisture
Evaporation takes away heat to achieve the purpose that cooling is brought down a fever, while the freshener and active material added in hydrogel locally plays
Relieveing pain and refreshing effect.Defervescence plaster used use is simple and convenient, is suitable for the clinical symptoms such as children acute fever, headache and strain.But
Existing defervescence plaster used effect duration of bringing down a fever is shorter, and the not temperature sensitivity of quick response.
Summary of the invention
In view of this, it is defervescence plaster used and preparation method thereof the present invention provides a kind of control-release long-acting, for solving existing bring down a fever
Patch effect duration of bringing down a fever it is shorter, and not the temperature sensitivity of quick response the problem of.
The specific technical solution of the present invention is as follows:
A kind of control-release long-acting is defervescence plaster used, comprising: back sheet, hydrogel layer and the protective film layer set gradually；
The hydrogel layer is dispersed with microcapsules, and the encapsulation has volatile essential oil；
The microcapsules are hydrophily chitosan nano mcirocapsule.
Preferably, the partial size of the hydrophily chitosan nano mcirocapsule is 50nm~1000nm.
Preferably, the mass ratio of the hydrophily chitosan nano mcirocapsule and the hydrogel layer be 0~30:60~
100。
Preferably, the volatile essential oil includes one in peppermint oil, borneol, asbolin, lemon and eucalyptus leaf essential oil
Kind is a variety of.
Preferably, the hydrogel layer is prepared by polymeric gel agent；
The polymeric gel agent includes high molecular polymer, moisturizer, crosslinking agent and cross-linking regulator.
Preferably, the mass ratio of the high molecular polymer, the moisturizer, the crosslinking agent and the cross-linking regulator
For 15~30:10~30:0.01~2:0.05~0.5.
The present invention also provides a kind of preparation methods that control-release long-acting is defervescence plaster used, comprising the following steps:
Hydrogel layer is dispersed by the hydrophily chitosan nano mcirocapsule for being enclosed with volatile essential oil, then in the water-setting
The two sides of glue-line bond back sheet and protective film layer respectively, and it is defervescence plaster used to obtain control-release long-acting.
Preferably, the hydrophily chitosan nano mcirocapsule for being enclosed with volatile essential oil is prepared via a method which
It arrives:
Hydrophily chitosan is dissolved in deionized water, chitosan aqueous solution is made；
The property of will volatilize essential oil is dissolved in organic solvent obtain essential oil solution and be scattered in emulsifier aqueous solution after, then with it is described
Chitosan aqueous solution is uniformly mixed and adjusts pH is coagulated reaction again, then is sprayed using coaxial nozzle, is obtained being enclosed with and be waved
The hydrophily chitosan nano mcirocapsule of hair property essential oil.
Preferably, the spraying nozzle rate is 1ml/min~15ml/min.
Preferably, the spraying air pressure is 0.3bar~0.5bar；
The spraying frequency is 40Hz~200Hz.
In conclusion the present invention provides a kind of control-release long-acting is defervescence plaster used, comprising: back sheet, the hydrogel set gradually
Layer and protective film layer；The hydrogel layer is dispersed with microcapsules, and the encapsulation has volatile essential oil；The microcapsules are
Hydrophily chitosan nano mcirocapsule.In the present invention, defervescence plaster used hydrogel layer is dispersed with microcapsules, and encapsulation has volatilization
Property essential oil, can make volatile essential oil slowly volatilize, improve and overcome volatile essential oil high volatility, be easily oxidized, effectively at
The defects of partial volume easily loses and its color and quality easily change with the extension of storage time extends this and defervescence plaster used brings down a fever
The duration of effect；The present invention it is defervescence plaster used have the function of it is dual bring down a fever, on the one hand using hydrogel layer energy transformation,
It is absorbed heat by vaporization, reaches rapid physical cooling, on the other hand utilize the volatility essence of the encapsulation of hydrogel layer setting
Oil plays antipyretic effect through skin；Microcapsules are hydrophily chitosan nano mcirocapsule, this is defervescence plaster used in use, patient temperature
Higher, the speed that the combination water in hydrogel layer is converted into Free water is faster, so that in hydrophily chitosan nano mcirocapsule
Volatile essential oil discharges faster, and then makes the defervescence plaster used temperature sensitivity for having quick response.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below
There is attached drawing needed in technical description to be briefly described.
Fig. 1 is the peppermint oil release profiles of the hydrophily chitosan nano mcirocapsule in the embodiment of the present invention.
Specific embodiment
It is defervescence plaster used and preparation method thereof the present invention provides a kind of control-release long-acting, for solving existing defervescence plaster used effect of bringing down a fever
The fruit duration is shorter, and not the temperature sensitivity of quick response the problem of.
The technical scheme in the embodiments of the invention will be clearly and completely described below, it is clear that described implementation
Example is only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without making creative work belongs to the model that the present invention protects
It encloses.
A kind of control-release long-acting is defervescence plaster used, comprising: back sheet, hydrogel layer and the protective film layer set gradually；
Hydrogel layer is dispersed with microcapsules, and encapsulation has volatile essential oil；
Microcapsules are hydrophily chitosan nano mcirocapsule.
In the present invention, defervescence plaster used hydrogel layer is dispersed with microcapsules, and encapsulation has volatile essential oil, can make to volatilize
Property essential oil slowly volatilize, improve and overcome volatile essential oil high volatility, be easily oxidized, effective component be easy loss and its face
The defects of color and quality easily change with the extension of storage time, extends the duration of the defervescence plaster used effect of bringing down a fever；
The present invention it is defervescence plaster used have the function of it is dual bring down a fever, on the one hand utilize hydrogel layer energy transformation, by vaporization heat absorption, reach
Cool down to rapid physical, is on the other hand moved back using the volatile essential oil of the encapsulation of hydrogel layer setting through skin performance
Heat effect；Microcapsules are hydrophily chitosan nano mcirocapsule, this is defervescence plaster used in use, patient temperature is higher, in hydrogel layer
Combination water be converted into Free water speed it is faster so that the volatile essential oil in hydrophily chitosan nano mcirocapsule discharges
Faster, and then make the defervescence plaster used temperature sensitivity for having quick response.
In the present invention, the partial size of hydrophily chitosan nano mcirocapsule is 50nm~1000nm.
The partial size of hydrophily chitosan nano mcirocapsule is preferably 200nm~1000nm.
In the present invention, the mass ratio of hydrophily chitosan nano mcirocapsule and hydrogel layer is 0~30:60~100.
The mass ratio of hydrophily chitosan nano mcirocapsule and hydrogel layer is preferably 10~20:70~80.
In the present invention, volatile essential oil includes one of peppermint oil, borneol, asbolin, lemon and eucalyptus leaf essential oil
Or it is a variety of.
Peppermint oil is the active constituent extracted from peppermint stem and leaf, has clearing away heat and removing summer effect and is widely used in refrigerant
In the products such as oil, anodyne, toothpaste, candy.Asbolin is the work with tranquilizing effect obtained from pine roots wood temples portion
Property ingredient.Peppermint oil, borneol, asbolin, lemon and eucalyptus leaf essential oil are derived from the extract of natural plants, safety, perfume
Taste persistently, can relieving mental strain and helping sleep and be conducive to play cooling effect.
Peppermint oil is made from the stem and leaf of fresh mint through distilling, and has special refrigerant fragrance.Peppermint oil high volatility,
It is easily oxidized, the color and quality for being easy loss and peppermint oil can also change with the extension of storage time, and the present invention will
Peppermint oil is wrapped in hydrophily chitosan nano mcirocapsule, can improve and overcome above-mentioned deficiency, improve the exploitation of peppermint oil
Utility value.
It should be noted that volatile essential oil may also include edible fragrant constituents, make defervescence plaster used with the fragrance of a flower or fruit
Temperature, and then it is defervescence plaster used using this to allow patient to be easier to.
The present invention defervescence plaster used back sheet, hydrogel layer and protective film layer are successively pasted, and protective film layer protects hydrogel layer
It is environmentally isolated with, for the glue film that can be opened, it can be compound that glue film, which can be selected from transparent or opaque glassine paper or plastic foil etc.,
With the materials such as polyethylene film or high temperature resistance polyester film.Hydrogel layer is defervescence plaster used main part, and hydrogel layer is using tool
The water soluble polymer gel for having good energy conversion function is carrier, add one or more kinds of extracted form natural plants at
Divide or other active components, retentiveness are good.
The defervescence plaster used present invention is a kind of topical patch preparation, in its local use, by the defervescence plaster used skin applied in user
It on skin surface, and is kept on certain time in application site, to reach cooling effect.The defervescence plaster used not only hydrophily is strong, ventilative
Property it is good, water penetration is good, water imbibition is strong and retentiveness is good, and also have the characteristics that tensile strength and elasticity it is strong.The present invention brings down a fever
The hydrogel layer of patch has good biocompatibility, and clean and safe will not generate stimulation to skin.The present invention is defervescence plaster used can be with
It is applied to arm, leg, trunk and first-class any suitable part, the active skull cap components such as volatile essential oil of addition have clear
Cool analgesic activity, and then expanded and defervescence plaster used relieved pain, cooling of reducing swelling, arousing brain, raising spirit, relax one's muscles and improve sleep etc.
Multiple functions are suitable for the multiple fields such as medicine, sports goods, articles for daily use.
In the present invention, hydrogel layer is prepared by polymeric gel agent；
Polymeric gel agent includes high molecular polymer, moisturizer, crosslinking agent and cross-linking regulator.
High molecular polymer, moisturizer, crosslinking agent and cross-linking regulator mass ratio be 15~30:10~30:0.01~
2:0.05~0.5.
High molecular polymer, moisturizer, crosslinking agent and cross-linking regulator mass ratio be preferably 20~25:15~20:0.1
~0.2:0.1~0.2.
In the present invention, high molecular polymer is selected from gelatin, starch, agar, mannosan, carbomer, alginic acid, polypropylene
Acid, Sodium Polyacrylate, dextrin, methylcellulose, sodium carboxymethylcellulose pyce, hydroxypropyl cellulose, sodium carboxymethylcellulose, carboxymethyl
Cellulose, carboxyl vinyl polymer, polyvinyl alcohol, poly- second special bags of willow branches, framed by bamboo, for building dykes pyrrolidones, gum arabic, bassora gum, gum karaya,
Starch acrylate copolymer or starch acrylamide acid sodium；High molecular polymer be further selected from gelatin, starch, agar, mannosan,
Carbomer, alginic acid, polyacrylic acid, Sodium Polyacrylate, dextrin, methylcellulose, sodium carboxymethylcellulose pyce, hydroxypropyl cellulose, carboxylic
Sodium carboxymethylcellulose pyce, carboxymethyl cellulose, carboxyl vinyl polymer, polyvinyl alcohol, poly- second special bags of willow branches, framed by bamboo, for building dykes pyrrolidones, Arabic tree
Glue, bassora gum, gum karaya, starch acrylate copolymer or starch acrylamide acid sodium metal salt；High molecular polymer is also
It can be selected from gelatin, starch, agar, mannosan, carbomer, alginic acid, polyacrylic acid, Sodium Polyacrylate, dextrin, Methyl cellulose
Element, hydroxypropyl cellulose, sodium carboxymethylcellulose, carboxymethyl cellulose, carboxyl vinyl polymer, gathers sodium carboxymethylcellulose pyce
Vinyl alcohol, polyvinylpyrrolidone, gum arabic, bassora gum, gum karaya, starch acrylate copolymer or starch third
The product that olefin(e) acid sodium is cross-linked to form by organic or inorganic.
There is good biocompatibility using polymeric gel agent prepared by polyvinyl alcohol and polyacrylic acid, it will not be to people
Body skin causes stimulation or sense of discomfort.It should be noted that polyvinyl alcohol can be replaced dextran, dextran and polypropylene
The polymeric gel agent swellability and water-retaining property of acid preparation are good.
In the present invention, moisturizer is selected from glycerol, sorbierite, diethylene glycol (DEG), 1,3-BDO, glycerine, propylene glycol or poly- second
Glycol.Crosslinking agent is selected from alchlor, aluminum oxide or Dihydroxyaluminium Aminoacetate.Cross-linking regulator is selected from citric acid, tartaric acid, ice vinegar
Acid, citric acid or formic acid.
In the present invention, polymeric gel agent further includes cosolvent, and cosolvent is organic cosolvent, for dissolve activity at
Point.Organic cosolvent is selected from n-methyl-2-pyrrolidone, diethyltoluamide, ethyl alcohol, methanol, polyethylene glycol or nutmeg
Isopropyl propionate.Mass percent of the cosolvent in polymeric gel agent is 0.1%~5%.
Polymeric gel agent further includes p-hydroxybenzoate, anion, cation and nonionic surface active agent etc..
Hydrogel layer further includes oils, and oils can be selected from jojoba oil or steam sesame oil；Hydrogel layer further includes pH adjusting agent to adjust
The pH value of hydrogel layer is 4.0~7.0, and pH adjusting agent is selected from malic acid, tartaric acid or diisopropanolamine (DIPA)；Hydrogel layer further includes
Alcohols, alcohols are selected from ethyl alcohol.
In the present invention, the material of back sheet is flexible material, conveniently adapts to human motion.Also, flexible material is ventilative
Property material.Poromeric material is selected from supatex fabric, Woven fabric, ammonia human relations fiber or flannel；Poromeric material is further selected from
Supatex fabric, Woven fabric, ammonia human relations fiber or flannel and polyethylene film, ethylene glycol terephthalate film, polychlorostyrene
The laminate of vinyl film, second Xi-acetic acid, vinyl ester copolymers film or polyurethane film.
The present invention it is defervescence plaster used have the function of it is dual bring down a fever, on the one hand using hydrogel layer energy transformation, pass through vapour
Change heat absorption, reaches rapid physical cooling；On the other hand it is penetrated using the volatile essential oil of the encapsulation of hydrogel layer setting
Skin plays antipyretic effect.The microcapsules property of will volatilize essential oil package during the present invention is defervescence plaster used improves and overcomes volatility essence
Oily high volatility, be easily oxidized, effective component is easy loss and its color and quality easily become with the extension of storage time
The defects of change, it is ensured that and extend the duration of defervescence plaster used effect of bringing down a fever.Also, microcapsules are that hydrophily chitosan nano is micro-
Capsule, this is defervescence plaster used in use, patient temperature is higher, and the speed that the combination water in hydrogel layer is converted into Free water is faster, makes
The volatile essential oil obtained in hydrophily chitosan nano mcirocapsule discharges faster, and then makes the defervescence plaster used temperature for having quick response
Spend sensibility.The defervescence plaster used volatile essential oil Cutaneous permeation of the present invention is made good use of, and advantages of nontoxic raw materials side effect, skin contained by heat posted are solved
Compatibility is good, without skin irritation, noresidue, water content height, good water-retaining property, toughness is strong, good permeability, will not be to skin
Generate any discomfort sense.It is not required to freezing equipment when defervescence plaster used use of the invention, is not required to pre-coo time, when use opens packaging, glues
Forehead or other positions are affixed on, without time, can be used at any time, it is easy to use, and there is cooling to ease pain, is refrigerant refreshing
Effect, use is easy to clean, safe and non-toxic, is especially suitable for children and uses, and can be used for cold compress physical therapy, alleviates pain and cooling of relieving summer heat
Deng, it may also be used for arousing brain, raising spirit, relax one's muscles, improve sleep, skin moisture-keeping and beauty etc., can be applied to medicine, sports goods,
The fields such as beauty and articles for daily use.
The present invention also provides a kind of preparation methods that control-release long-acting is defervescence plaster used, comprising the following steps:
Hydrogel layer is dispersed by hydrophily chitosan nano mcirocapsule, then bonds backing respectively in the two sides of hydrogel layer
Layer and protective film layer, it is defervescence plaster used to obtain control-release long-acting.
In the present invention, hydrophily chitosan nano mcirocapsule is prepared via a method which to obtain:
Hydrogel layer is dispersed by the hydrophily chitosan nano mcirocapsule for being enclosed with volatile essential oil, then in hydrogel layer
Two sides bond back sheet and protective film layer respectively, it is defervescence plaster used to obtain control-release long-acting.
In the present invention, the hydrophily chitosan nano mcirocapsule for being enclosed with volatile essential oil is prepared via a method which
It arrives:
Hydrophily chitosan is dissolved in deionized water, chitosan aqueous solution is made；
The property of will volatilize essential oil is dissolved in organic solvent obtain essential oil solution and be scattered in emulsifier aqueous solution after, then it is poly- with shell
Sugar aqueous solution is uniformly mixed and adjusts pH is coagulated reaction again, then is sprayed using coaxial nozzle, obtains being enclosed with volatility
The hydrophily chitosan nano mcirocapsule of essential oil.
In the present invention, the hydrophily chitosan nano mcirocapsule for being enclosed with volatile essential oil is prepared especially by following method
It obtains:
Hydrophily chitosan is dissolved in deionized water, chitosan aqueous solution is made；Peppermint oil is dissolved in ethyl alcohol obtain it is thin
Lotus oil ethanol solution and after being scattered in Arabic gum aqueous solution, then be uniformly mixed with chitosan aqueous solution and adjust pH and coagulated again
Reaction, then be sprayed using coaxial nozzle, obtain the hydrophily chitosan nano mcirocapsule for being enclosed with volatile essential oil.
Be uniformly mixed again with chitosan aqueous solution and adjust pH coagulated again react further be specially again with chitosan water
Solution is uniformly mixed and adjusts pH to 4.0~5.5 is coagulated reaction again.
In the present invention, spraying nozzle rate is 1ml/min~15ml/min, more preferably 5ml/min.
Spraying air pressure is 0.3bar~0.5bar；
Spraying frequency is 40Hz~200Hz.
In the present invention, the mass ratio of hydrophily chitosan and deionized water is 2:50~95, more preferably 2:75；Emulsifier
Selected from Arabic gum, poloxamer188 or decyl glucoside, the mass ratio of volatile essential oil and emulsifier is 0.2:5~10,
More preferably 0.2:6.
The defervescence plaster used preparation method of the present invention is simple, is readily produced.
For a further understanding of the present invention, the present invention will be described in detail combined with specific embodiments below.
The preparation of 1 hydrophily chitosan nano mcirocapsule of embodiment
1) 2g hydrophily chitosan is dissolved in 50g deionized water, and adjusts pH to 2.0~3.5, A phase is made；
2) 0.3g peppermint oil is evenly dispersed into 4g ethyl alcohol, and the Arabic gum aqueous solution that 40g concentration is 15% is added
In, obtain B phase；
3) A is added in B phase and adjusts pH to 4.0~5.5 after mixing, and under the conditions of 500rpm~700rpm into
Row 60min coagulates reaction again and obtains peppermint oil-chitosan-Arabic gum condensation product；It is sprayed using B-395 coaxial nozzle,
In, 450 μm/900 μm of inner nozzle/outer nozzle, flow 3mL/min, air pressure 300mbar, stirring 100%, frequency 70Hz, amplitude 5,
Obtain the hydrophily chitosan nano mcirocapsule of uniform-spherical.
The sustained release performance of 2 Static Headspace method of embodiment measurement hydrophily chitosan nano mcirocapsule
1) standard curve determination is respectively by the thin of 0.002g, 0.004g, 0.006g, 0.01g, 0.015g, 0.02g, 0.04g
The deionized water of 0.5% Tween-80 of lotus oil and 10mL is put into ml headspace bottle, is covered, is strongly stirred in 37 DEG C of water bath with thermostatic control
It mixes, after ready to balance, takes out 0.25mL headspace gas with syringe and carry out gas chromatographic analysis.Use menthol peak as containing in map
Figureofmerit calculates peppermint oil burst size.GC conditions are as follows: gas chromatograph: GC-14BPF+HSS-2B type；Chromatographic column:
CBPI0.53mm × 25m, df=3.0 μm；Chromatographic condition: 60 DEG C of initial temperature, 3min, 5 DEG C/min temperature programming to 200 are kept the temperature
DEG C, keep the temperature 10min.Using the peak area of menthol and internal standard compound as ordinate, menthol mass concentration is abscissa, obtains and linearly returns
Return equation are as follows:
Y=6.995 × 10-5+ 0.142x, r=0.9999.
The result shows that menthol mass concentration is within the scope of 1.0mg/ml~5.0mg/ml, the concentration of peak area is in good line
Sexual intercourse.
2) hydrophily chitosan nano mcirocapsule measures: weighing 0.10g hydrophily chitosan nano mcirocapsule, is placed in drying
30mL ml headspace bottle in, stirrer is placed in ml headspace bottle, the deionized water of 10mL0.5% Tween-80 is added in the ml headspace bottle, and
Start timing.It covers, then ml headspace bottle is put into 37 DEG C of water bath with thermostatic control, while with the magnetic agitation of strength immediately.?
0.5h, 1h, 2h, 4h, 6h, 8h carry out headspace analysis respectively.0.25mL static headspace gas is taken out with 0.25mL hermetic type gas syringe
Body carries out gas chromatographic analysis.GC conditions such as step 1).
Referring to Fig. 1, for the peppermint oil release profiles of the hydrophily chitosan nano mcirocapsule in the embodiment of the present invention.Knot
Fruit shows that peppermint oil microencapsulation has good slow release effect, and release time is lasting, is longer than 10h, illustrates that the present invention brings down a fever
The duration for pasting effect of bringing down a fever is long.
The preparation of 3 polymeric gel agent of embodiment
8g polyacrylic acid and 0.4g Dihydroxyaluminium Aminoacetate are weighed into 30ml glycerol and is mixed, glycerol suspension is obtained；Weigh 0.3g
Tartaric acid is dissolved in 91g deionized water, is added at one time after adjusting pH to 4.0~7.0 into glycerol suspension and is stirred evenly, obtains
To polymeric gel agent.
The defervescence plaster used preparation of embodiment 4
8g polyacrylic acid and 0.4g Dihydroxyaluminium Aminoacetate are weighed into 30ml glycerol and is mixed, glycerol suspension is obtained；Weigh 25g reality
It applies 1 gained hydrophily chitosan nano mcirocapsule of example and is added into the aqueous tartaric acid solution of 91ml tartaric acid containing 0.3g, adjust
It is added at one time after pH to 4.0~7.0 in glycerol suspension after mixing evenly, pours into mold or coated machine is applied to backing
On layer, solidify, while covering protection film layer, is packed after cutting, be made defervescence plaster used.
Embodiment 5
Sticked on defervescence plaster used on qualified health volunteer's forehead, using infrared radiation thermometer 0h, 1h, 3h,
5h, 7h, 9h are measured respectively sticks place's skin surface temperature and elsewhere skin surface temperature, observes cooling effect.Separately with
Upper time point simultaneously weighs defervescence plaster used weight, the weight change of observation period in use.Cooling test effect is shown in Table 1.1 knot of table
Fruit shows that the duration of the defervescence plaster used effect of bringing down a fever of the present invention is long, and this is defervescence plaster used in use, body temperature is higher, and hydrophily shell is poly-
Volatile essential oil in sugared capsule of nano discharges faster, the defervescence plaster used temperature sensitivity for having quick response.
1 defervescence plaster used cooling effect (n=10) of table
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of control-release long-acting is defervescence plaster used characterized by comprising back sheet, hydrogel layer and the protective film layer set gradually；
The hydrogel layer is dispersed with microcapsules, and the encapsulation has volatile essential oil；
The microcapsules are hydrophily chitosan nano mcirocapsule.
2. control-release long-acting according to claim 1 is defervescence plaster used, which is characterized in that the hydrophily chitosan nano mcirocapsule
Partial size be 50nm~1000nm.
3. control-release long-acting according to claim 1 is defervescence plaster used, which is characterized in that the hydrophily chitosan nano mcirocapsule
Mass ratio with the hydrogel layer is 0~30:60~100.
4. control-release long-acting according to claim 1 is defervescence plaster used, which is characterized in that the volatile essential oil include peppermint oil,
One of borneol, asbolin, lemon and eucalyptus leaf essential oil are a variety of.
5. control-release long-acting according to claim 1 is defervescence plaster used, which is characterized in that the hydrogel layer is by polymeric gel agent
It is prepared；
The polymeric gel agent includes high molecular polymer, moisturizer, crosslinking agent and cross-linking regulator.
6. control-release long-acting according to claim 5 is defervescence plaster used, which is characterized in that the high molecular polymer, the moisturizing
The mass ratio of agent, the crosslinking agent and the cross-linking regulator is 15~30:10~30:0.01~2:0.05~0.5.
7. a kind of preparation method that control-release long-acting is defervescence plaster used, which comprises the following steps:
Hydrogel layer is dispersed by the hydrophily chitosan nano mcirocapsule for being enclosed with volatile essential oil, then in the hydrogel layer
Two sides bond back sheet and protective film layer respectively, it is defervescence plaster used to obtain control-release long-acting.
8. preparation method according to claim 7, which is characterized in that the hydrophily shell for being enclosed with volatile essential oil is poly-
Sugared capsule of nano is prepared via a method which to obtain:
Hydrophily chitosan is dissolved in deionized water, chitosan aqueous solution is made；
The property of will volatilize essential oil is dissolved in organic solvent obtain essential oil solution and be scattered in emulsifier aqueous solution after, then it is poly- with the shell
Sugar aqueous solution is uniformly mixed and adjusts pH is coagulated reaction again, then is sprayed using coaxial nozzle, obtains being enclosed with volatility
The hydrophily chitosan nano mcirocapsule of essential oil.
9. preparation method according to claim 8, which is characterized in that the spraying nozzle rate be 1ml/min~
15ml/min。
10. preparation method according to claim 9, which is characterized in that the spraying air pressure is 0.3bar~0.5bar；
The spraying frequency is 40Hz~200Hz.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114732798A (en) * | 2022-03-14 | 2022-07-12 | 珠海国佳新材股份有限公司 | Medical gel patch |
| CN116966224A (en) * | 2023-04-27 | 2023-10-31 | 广东省时珍本草科学研究院 | Preparation method of silver Hu Ganmao antipyretic external preparation |
Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995017866A1 (en) * | 1993-12-30 | 1995-07-06 | Royds Robert B | Transdermal drug delivery system |
| CN1144087A (en) * | 1995-04-28 | 1997-03-05 | 立德化学株式会社 | Medicine release control type percutaneous absorber |
| CN1387920A (en) * | 2001-05-17 | 2003-01-01 | 庄臣及庄臣工商有限公司 | Adhesive bandage |
| CN101928641A (en) * | 2010-09-29 | 2010-12-29 | 江南大学 | Essence microcapsule with long-term effectiveness and preparation method thereof |
| US20110004150A1 (en) * | 2002-12-31 | 2011-01-06 | Ultra-Sonic Technologies, L.L.C. | Transdermal Delivery Using Encapsulated Agent Activated by Ultrasound and or Heat |
| CN103800206A (en) * | 2012-12-30 | 2014-05-21 | 苏州福兴纳米科技有限公司 | Heating type beauty mask |
| CN104688408A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Medical defervescence patch and preparation method thereof |
| CN204379527U (en) * | 2014-12-31 | 2015-06-10 | 黑龙江省信泰医药科技开发有限公司 | Plants essential oil type heat discoloration defervescence plaster used |
| CN204744612U (en) * | 2015-07-17 | 2015-11-11 | 张辉海 | Woundplast with ice compress effect |
| CN204839932U (en) * | 2015-07-14 | 2015-12-09 | 嘉恒医药（江苏）有限公司 | Scar dressing |
| CN204863344U (en) * | 2015-07-29 | 2015-12-16 | 张云叶 | Tourniquet with ice compress effect |
| CN105165911A (en) * | 2015-07-14 | 2015-12-23 | 浙江理工大学 | Preparation method of herba schizonepetae essential oil nanometer mosquito-repellent microcapsules |
| CN105496635A (en) * | 2016-01-21 | 2016-04-20 | 江苏得迪医疗器械有限公司 | Water-retention slow-release fever cooling paster and making method thereof |
| CN206120565U (en) * | 2016-06-03 | 2017-04-26 | 源之初生物科技（深圳）有限公司 | Sanitary pad |
| CN106632900A (en) * | 2016-11-22 | 2017-05-10 | 孙祎 | Method for preparing functional heating patch |
| CN107335091A (en) * | 2017-08-31 | 2017-11-10 | 河南汇博医疗股份有限公司 | A kind of long acting antibiotic hydrogel and preparation method thereof |
| CN107419527A (en) * | 2017-06-23 | 2017-12-01 | 宁波高新区达康工业科技有限公司 | A kind of mosquito-proof refrigerant fabric for infant-wear |
-
2018
- 2018-07-12 CN CN201810765972.8A patent/CN109124862B/en active Active
Patent Citations (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995017866A1 (en) * | 1993-12-30 | 1995-07-06 | Royds Robert B | Transdermal drug delivery system |
| CN1144087A (en) * | 1995-04-28 | 1997-03-05 | 立德化学株式会社 | Medicine release control type percutaneous absorber |
| CN1387920A (en) * | 2001-05-17 | 2003-01-01 | 庄臣及庄臣工商有限公司 | Adhesive bandage |
| US20110004150A1 (en) * | 2002-12-31 | 2011-01-06 | Ultra-Sonic Technologies, L.L.C. | Transdermal Delivery Using Encapsulated Agent Activated by Ultrasound and or Heat |
| CN101928641A (en) * | 2010-09-29 | 2010-12-29 | 江南大学 | Essence microcapsule with long-term effectiveness and preparation method thereof |
| CN103800206A (en) * | 2012-12-30 | 2014-05-21 | 苏州福兴纳米科技有限公司 | Heating type beauty mask |
| CN204379527U (en) * | 2014-12-31 | 2015-06-10 | 黑龙江省信泰医药科技开发有限公司 | Plants essential oil type heat discoloration defervescence plaster used |
| CN104688408A (en) * | 2015-03-12 | 2015-06-10 | 施敬东 | Medical defervescence patch and preparation method thereof |
| CN105165911A (en) * | 2015-07-14 | 2015-12-23 | 浙江理工大学 | Preparation method of herba schizonepetae essential oil nanometer mosquito-repellent microcapsules |
| CN204839932U (en) * | 2015-07-14 | 2015-12-09 | 嘉恒医药（江苏）有限公司 | Scar dressing |
| CN204744612U (en) * | 2015-07-17 | 2015-11-11 | 张辉海 | Woundplast with ice compress effect |
| CN204863344U (en) * | 2015-07-29 | 2015-12-16 | 张云叶 | Tourniquet with ice compress effect |
| CN105496635A (en) * | 2016-01-21 | 2016-04-20 | 江苏得迪医疗器械有限公司 | Water-retention slow-release fever cooling paster and making method thereof |
| CN206120565U (en) * | 2016-06-03 | 2017-04-26 | 源之初生物科技（深圳）有限公司 | Sanitary pad |
| CN106632900A (en) * | 2016-11-22 | 2017-05-10 | 孙祎 | Method for preparing functional heating patch |
| CN107419527A (en) * | 2017-06-23 | 2017-12-01 | 宁波高新区达康工业科技有限公司 | A kind of mosquito-proof refrigerant fabric for infant-wear |
| CN107335091A (en) * | 2017-08-31 | 2017-11-10 | 河南汇博医疗股份有限公司 | A kind of long acting antibiotic hydrogel and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 余松林、俞昊、功靓、朱美芳、陈彦模: "同轴电喷法制备PCL-蛋清体系复合微胶囊", 《功能高分子学报》 * |
| 皮佳鑫、栾瀚森、杨莉、王浩: "生物可降解聚合物微球的制备设备概况", 《中国医药工业杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114732798A (en) * | 2022-03-14 | 2022-07-12 | 珠海国佳新材股份有限公司 | Medical gel patch |
| CN116966224A (en) * | 2023-04-27 | 2023-10-31 | 广东省时珍本草科学研究院 | Preparation method of silver Hu Ganmao antipyretic external preparation |
| CN116966224B (en) * | 2023-04-27 | 2024-03-19 | 广东省时珍本草科学研究院 | Preparation method of silver Hu Ganmao antipyretic external preparation |
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