JP6594937B2 - Sheet-like pack and method for producing the same - Google Patents

Description

  The present invention relates to a sheet-like pack agent that can be suitably used as cosmetics, pharmaceuticals, quasi drugs, or miscellaneous goods, and a method for producing the same.

In recent years, sheet-shaped packs are generally used as cosmetics, pharmaceuticals, quasi drugs, or miscellaneous goods (products that are not subject to the Pharmaceutical Affairs Law). Conventional sheet adhesives such as tapes and shipping agents are used for therapeutic purposes such as improvement of symptoms such as low back pain, stiff shoulders, bruises and sprains, and reduction of foot fatigue. The pack is mainly used in cosmetic applications for adjusting the condition of the face and body skin. In the skin, it is ideal that the stratum corneum moisture content is about 10 to 20%, and that epidermal lipids and natural moisturizing factors (amino acids, urea, lactic acid, etc.) are always 0.4 to 0.05 mg / cm ^2. State (healthy skin). If this balance is lost, the barrier function of the skin is lowered, and skin troubles such as extreme skin dryness, excessive sebum due to excessive sebum secretion, rough skin, pimples, and acne are likely to occur. For this reason, in order to improve and maintain such a balance, the sheet-shaped pack agent is required to have characteristics such as a moisturizing function for the skin of the face and body and suppression of excessive sebum secretion. Furthermore, in addition to this, in the sheet-like pack used for cosmetic purposes as described above, it is more excellent in use feeling than the above-mentioned sheet-like patch, and suppresses peeling / damage of the stratum corneum. Therefore, various properties such as more appropriate adhesiveness to the skin and more appropriate adhesion to the skin are required.

  As the sheet-like pack agent, for example, in JP-A-8-188527 (Patent Document 1), simplicity, appropriate adhesiveness and moisture retention to the skin, stability of the physical properties of the preparation, safety to the skin, and use For the purpose of improving the feeling of use and the pack effect, the sheet-shaped pack agent contains a water-soluble polymer, a polyhydric alcohol, a moisturizing component, a cross-linking agent, a beautifying skin component, and water. It is described. Furthermore, in JP-A-2006-206540 (Patent Document 2), for the purpose of maintaining the skin moisturizing effect for a long time after peeling, the base of the sheet-like pack agent provided with a support and a base is used. In addition, it is described that a hybrid gel of hydrogel and oil gel is contained.

  Moreover, what is equipped with the base layer containing a gel-like base is known as a form of the said sheet-like pack agent. Japanese Patent Application Laid-Open No. 2004-75540 (Patent Document 3) discloses a vinyl polymer, a cellulose polymer, a liquid as an external gel-like composition for the purpose of improving water repellency, moisture retention and coating properties. An external gel composition containing an oil and a fatty acid dextrin is described. Furthermore, JP-A-8-277302 (Patent Document 4) comprises a specific dextrin fatty acid ester which is an esterified product of dextrin and a fatty acid as a gelling agent for the purpose of obtaining a highly thixotropic gel. Gelling agents are described.

  Further, as the sheet-like patch, for example, in WO2015 / 025935 (Patent Document 5), a poultice having a paste layer on a support layer is described, and the paste layer is It is described that it is obtained by mixing a neutralized polyacrylic acid product, a poly (methyl acrylate / 2-ethylhexyl acrylate) emulsion, and water.

JP-A-8-188527 JP 2006-206540 A JP 2004-75540 A JP-A-8-277302 International Publication No. 2015/025935

  From the viewpoint of improving the feeling of use (feeling of skin familiarity), improving and maintaining the barrier function of the skin, and suppressing excessive sebum secretion, the sheet pack should contain more oil components (oil-based components). Is desired. However, the present inventors have found that when a large amount of oil component is contained in the base layer containing the gel-like base of the sheet-like pack agent, the uniformity, cohesive force, adhesive strength, and adhesion to the skin of the base layer It has been found that the properties as a sheet-like pack agent are required because the properties and the like may be lowered.

  The present invention has been made in view of the above problems, and even when a relatively large amount of oil component is contained, the uniformity of the base layer, cohesive force, adhesive force, and adhesion to the skin, In addition, it is an object of the present invention to provide a sheet-like pack agent that is excellent in the feeling of use at the time of use and sufficiently reduces pain at the time of peeling, and a method for producing the same.

  As a result of intensive studies to achieve the above object, the inventors of the present invention are selected from polyhydric alcohol fatty acid esters and fatty acids in the base layer of the sheet-like pack agent including the support layer and the base layer. A hybrid gel in which an oil gel containing at least one kind and a dextrin fatty acid ester is included in a hydrogel containing a water-soluble polymer, water, and a crosslinking agent; and a polymethyl 2-ethylhexyl polyacrylate In addition, the content of polymethyl acrylate / 2-ethylhexyl acrylate copolymer in the base layer is within a specific range, whereby an oil component (the polyhydric alcohol fatty acid) is added. At least one selected from the group consisting of an ester and the fatty acid (hereinafter referred to as “polyhydric alcohol”). Even if it contains a large amount of “fatty acid ester and / or fatty acid”)), all of them are excellent in the uniformity of the base layer, cohesive strength, adhesive strength, adhesion to the skin, and feeling during use. In addition, the present inventors have found that a sheet-like pack agent can be obtained in which pain during peeling is sufficiently reduced, and the present invention has been completed.

That is, the sheet pack of the present invention is a sheet pack comprising a support layer and a base layer,
The base layer contains a hybrid gel in which an oil gel is included in a hydrogel, and a polymethyl acrylate / 2-ethylhexyl acrylate copolymer,
The hydrogel contains a water-soluble polymer, water and a crosslinking agent;
The oil gel comprises a polyhydric alcohol fatty acid ester le, which contains a dextrin fatty acid ester,
The content of the polyhydric alcohol fatty acid ester in the base layer is 20 to 28% by mass,
Ri The content of polyacrylic acid methyl 2-ethylhexyl acrylate copolymer is from 1.77 to 5.90% by mass in the base layer, and,
Mass ratio of content of polyhydric alcohol fatty acid ester and content of polymethyl acrylate / 2-ethylhexyl acrylate copolymer in the base layer (polyhydric alcohol fatty acid ester content: polymethyl acrylate) - the content of 2-ethylhexyl acrylate copolymer) is 20: 5.90 to 20: Ru 1.77 der,
It is characterized by this.

The method for producing a sheet-like pack agent of the present invention is a method for producing a sheet-like pack agent comprising a support layer and a base layer,
Obtaining a polyhydric alcohol fatty acid ester le, a dextrin fatty acid ester, a oil gel containing,
Mixing the oil gel, polymethyl acrylate / acrylic acid 2-ethylhexyl copolymer, and water to obtain an oil gel composition;
Mixing the oil gel composition with a water-soluble polymer and a crosslinking agent to obtain a mixed composition; and
A hybrid gel in which the water gel is cross-linked, and the oil gel is included in a hydrogel containing the water-soluble polymer, the water and the cross-linking agent; and the polymethyl acrylate and 2-ethylhexyl polyacrylate A step of obtaining a base layer containing a copolymer,
The content of the polyhydric alcohol fatty acid ester in the base layer is 20 to 28% by mass,
Ri The content of polyacrylic acid methyl 2-ethylhexyl acrylate copolymer is from 1.77 to 5.90% by mass in the base layer, and,
Mass ratio of content of polyhydric alcohol fatty acid ester and content of polymethyl acrylate / 2-ethylhexyl acrylate copolymer in the base layer (polyhydric alcohol fatty acid ester content: polymethyl acrylate) - the content of 2-ethylhexyl acrylate copolymer) is 20: 5.90 to 20: Ru 1.77 der,
It is characterized by this.

  According to the present invention, even in the case where a relatively large amount of oil component is contained, any of the base layer uniformity, cohesive strength, adhesive strength, and adhesion to the skin, as well as the feeling of use during use. In addition, it is possible to provide a sheet-like pack agent that is excellent in that the pain during peeling is sufficiently reduced, and a method for producing the same.

  Hereinafter, the present invention will be described in detail with reference to preferred embodiments thereof.

[Sheet pack]
First, the sheet-like pack agent of the present invention will be described. The sheet pack of the present invention is a sheet pack comprising a support layer and a base layer,
The base layer contains a hybrid gel in which an oil gel is included in a hydrogel, and a polymethyl acrylate / 2-ethylhexyl acrylate copolymer,
The hydrogel contains a water-soluble polymer, water and a crosslinking agent;
The oil gel contains at least one selected from the group consisting of polyhydric alcohol fatty acid esters and fatty acids, and dextrin fatty acid esters; and
The content of the polymethyl acrylate / acrylic acid 2-ethylhexyl copolymer in the base layer is 1.77 to 5.90 mass%.

  The sheet-like pack agent of this invention is equipped with a support body layer and the base material layer arrange | positioned on one surface of the said support body layer.

<Support layer>
The support layer is not particularly limited as long as it can support the base layer described later, and a known layer as a support layer for the sheet-shaped pack agent can be appropriately employed. Examples of the material of the support layer include: polyolefins such as polyethylene and polypropylene; polyesters such as polyethylene terephthalate; ethylene-vinyl acetate copolymers and vinyl chloride; polyurethanes; polyamides such as nylon; rayon; Cotton may be mentioned, and only one of them or a combination of two or more may be used. Examples of the form of the support layer include films; sheets; fabrics such as nonwoven fabrics, woven fabrics, and knitted fabrics by entanglement, thermal fusion, pressure bonding, or binder adhesion; and laminates thereof. Among these, the support layer is preferably a nonwoven fabric made of polyester. In this case, it is preferable that the basis weight of the nonwoven fabric is 20 to 200 g / ^{m 2,} more preferably from 40 to 120 g / ^{m 2,} further preferably 80 to 120 / ^{m 2.} If the basis weight is less than the lower limit, it tends to cause shape breakage such as tearing, appearance defects due to seepage during base layer formation, molding defects, difficulty in sticking at the time of sticking, etc., on the other hand, exceeding the upper limit. And there exists a tendency for the usability fall by the elasticity defect of a support body layer, and a softness | flexibility defect, and the dripping at the time of sticking, and a cost increase.

Although it does not restrict | limit especially as thickness of the said support body layer, It is preferable that it is 0.1-1.5 mm in thickness when it measures by the press of 0.98N per contact area 5cm < ² >, 0.5- It is preferable that it is 1.0 mm. When the thickness of the support layer is less than the lower limit, there is a tendency to cause shape failure such as tearing, appearance failure due to seepage at the time of forming the base layer, molding defects, difficulty in sticking at the time of sticking, When the above upper limit is exceeded, the support layer tends to cause a decrease in usability due to poor stretchability and poor flexibility, and to cause dripping and cost increase at the time of sticking.

  Furthermore, the color of the support layer is not particularly limited, but from the viewpoint of greatly affecting the product image and improving the aesthetics and the feeling of use during use, for example, white, skin color, yellow, red, amber , Green, blue, pink, light blue, and brown, and the ones that are adjusted in density as necessary, and those that have been subjected to processing such as printing and embossing can be appropriately used.

<Release liner>
The sheet-like pack agent of the present invention preferably further comprises a release liner on the surface of the base layer opposite to the support layer until use. Such a release liner is not particularly limited, and any known release liner for sheet-like pack agents can be appropriately employed. Examples of such release liner include at least one selected from polyethylene, polypropylene, polyethylene terephthalate, ethylene-vinyl acetate copolymer, ethylene-vinyl alcohol copolymer, vinyl chloride, polyurethane, polyester, and polyamide. A molded one is mentioned. Among these, the release liner is preferably a polyethylene terephthalate film or a polypropylene film.

  Although it does not restrict | limit especially as thickness of the said release liner, It is preferable that it is 20-150 micrometers, It is more preferable that it is 40-120 micrometers, It is further more preferable that it is 50-100 micrometers. If the thickness of the release liner is less than the lower limit, it tends to cause difficulty in sticking at the time of sticking, shape breakage such as tearing due to strength reduction, workability at the time of production, and lowering of line suitability, etc. Exceeding the above tendency tends to cause poor cutting suitability, dripping at the time of application, and cost increase.

  The release liner is preferably one that has been subjected to a release treatment such as a silicone coat on the surface in contact with the base layer so that it can be easily peeled off from the base layer. For the main purpose of improvement and improvement of peelability, those that have been processed and / or printed with secant lines and perforations; those that have been subjected to embossing etc. for the main purpose of improving the appearance and preventing displacement it can.

<Base layer>
The base layer according to the present invention contains a hybrid gel in which an oil gel is included in a hydrogel, and a polymethyl acrylate / 2-ethylhexyl acrylate copolymer.

[Hybrid gel]
The hybrid gel according to the present invention is a gel structure including a hydrogel mainly composed of a water-soluble component and an oil gel mainly composed of a lipid component and / or a fat-soluble component, and the oil gel is included in the hydrogel. Gel. In the present invention, “a gel in which an oil gel is included in a hydrogel” means a gel in which the oil gel is incorporated into a three-dimensional network space of the hydrogel obtained by crosslinking the water-soluble polymer with the crosslinking agent. I mean.

(Hydrogel)
The hydrogel according to the present invention is a gel containing water as a dispersion medium, which is a gel containing a water-soluble polymer, water and a crosslinking agent. The hydrogel is preferably a structure in which a crosslinked structure is introduced into the water-soluble polymer so as to be partially insolubilized and swollen with water.

  Examples of the water-soluble polymer according to the present invention include, for example, partially neutralized polyacrylic acid, completely neutralized polyacrylic acid, polyacrylic acid, sodium carboxymethylcellulose, gelatin, casein, pullulan, agar, dextran, sodium alginate, Soluble starch, carboxy starch, dextrin, carboxymethyl cellulose, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, polyvinyl alcohol, polyethylene oxide, polyacrylamide, polyvinyl pyrrolidone, carboxyvinyl polymer, polyvinyl ether, polymaleic acid copolymer, methoxyethylene maleic anhydride copolymer Coalesce, isobutylene maleic anhydride copolymer, and polyethyleneimine, and only one of them may be two or more It may be a mixture. Among these, the water-soluble polymer is preferably a polyacrylic acid partial neutralized product. In this case, the polyacrylic acid partial neutralized product is particularly preferably a sodium salt having a neutralization degree of 30 to 80% and an average polymerization degree of 1,000 to 100,000. .

  The content of the water-soluble polymer is preferably 3 to 10% by mass, more preferably 4 to 8% by mass, based on the mass of the entire base layer. If the content of the water-soluble polymer is less than the lower limit, the adhesive strength, cohesive strength, shape retention, etc. of the base layer are reduced, resulting in a decrease in feeling during use, a decrease in moisturizing effect, a medicinal component However, when the above upper limit is exceeded, the cohesive force of the base layer increases and the base layer is not uniform. There is a tendency that deterioration in workability and workability at the time of manufacture tends to occur.

  The water according to the present invention mainly has a function of dispersing and dissolving the following moisturizing components and the like as required in addition to the water-soluble polymer and the crosslinking agent according to the present invention. In addition, the water itself improves the feeling of use and after use of the sheet-like pack, transfers moisture to the skin and moisturizes the skin, relieves skin irritation and softens the skin. By this, it becomes possible to improve the absorbability of the following medicinal components. Examples of such water include purified water, sterilized water, natural water, and ordinary water, and only one of them or a mixture of two or more thereof may be used.

  In the sheet-like pack agent of the present invention, the water content is preferably 29.5 to 44.7% by mass, and 35.1 to 44.7% by mass based on the mass of the entire base layer. %, More preferably 38.0 to 43.5% by mass. If the water content is less than the lower limit, the adhesive strength, cohesive strength, shape retention, water absorption capacity, etc. of the base layer are reduced, the base layer becomes non-uniform, and the extensibility and work at the time of manufacture are reduced. Tend to cause a decrease in sexuality, a decrease in feeling during use, a decrease in moisturizing effect, a decrease in transdermal absorbability of medicinal ingredients, a decrease in skin safety, and the like. Adhesive strength, cohesive strength, shape retention, water absorption ability, etc. of the base layer are reduced, the base layer becomes non-uniform, and the base layer is oozed out (bleeding out) or sticking out (extruding) from the support layer. ), Decrease in extensibility and workability at the time of manufacture, decrease in feeling during use, decrease in transdermal absorbability of medicinal ingredients, decrease in skin safety, bleeding of oily components, etc. . The water content according to the present invention includes, in addition to the mass of water contained in the hydrogel, the mass of other water added during the production of the sheet-like pack agent, for example, the following polyacrylic acid It also includes the mass of water contained in the aqueous emulsion of 2-ethylhexyl methyl acrylate copolymer and water contained as the following beautifying skin component and moisturizing component.

  Examples of the cross-linking agent according to the present invention include polyvalent metal compounds, poorly water-soluble aluminum compounds, and polyfunctional epoxy compounds. Even if only one of them or a mixture of two or more of them, Good.

  The polyvalent metal compound is preferably a combination of synthetic aluminum silicate and magnesium aluminate metasilicate. Further, the magnesium aluminate metasilicate preferably has an antacid power (pH: 3 or more) according to the Fuchs method of 200 ml or more with 0.1 N hydrochloric acid consumption per 1 g. When the antacid power is less than the lower limit, the base layer from the backing layer (bleeding) or tongue sticking (extinguishing), the spreadability and workability at the time of manufacture, the time of application and storage Changes in physical properties, poor adhesion due to insufficient adhesive strength, poor adhesion due to excessive adhesive strength, redness, rash, blood congestion, decreased moisturizing effect, decreased percutaneous absorption of medicinal ingredients, bleeding of oily components, etc. It tends to occur.

  Examples of the poorly water-soluble aluminum compound include aluminum hydroxide, aluminum hydroxide gel, hydrous aluminum silicate, kaolin, aluminum acetate, aluminum lactate, aluminum stearate, and magnesium aluminate silicate. It may be only one type or a mixture of two or more types. By using the poorly water-soluble aluminum compound, it functions as a filler that gives an appropriate strength to the gel as well as suppressing skin irritation due to antacid action and skin astringent action due to a small amount of aluminum ions; A function of elution into the agent layer and suppressing a decrease in gel strength due to the time-dependent degradation of the polymer and the time-dependent cutting of the polymer-covalently crosslinked cross-linked portion can be expected. In addition, it is possible to control the elution rate of such aluminum ions by adjusting the pH of the base layer.

  Examples of the polyfunctional epoxy compound include polyethylene glycol diglycidyl ether, ethylene glycol diglycidyl ether, glycerin diglycidyl ether, glycerin triglycidyl ether, propylene glycol diglycidyl ether, polyglycerol polyglycidyl ether, sorbitol polyglycidyl ether, Examples include sorbitan polyglycidyl ether, trimethylolpropane triglycidyl ether, and pentaerythritol diglycidyl ether, and only one of them or a mixture of two or more thereof may be used. By using the polyfunctional epoxy compound, it is possible to expect better water absorption ability and shape retention, and it is possible to efficiently covalently bond with a water-soluble polymer having a carboxyl group, an amino group, or a hydroxyl group. It can also be expected that the gel strength will be higher when formed.

  As content of the crosslinking agent which concerns on this invention, it is preferable that it is 0.3-10 mass% on the basis of the mass of the whole said base layer, and it is more preferable that it is 0.3-7 mass%. If the content of the cross-linking agent is out of the above range, the base layer from the backing layer (bleeding) or tongue sticking (extinguishing), the extensibility and workability at the time of manufacture, the sticking and storage Changes in physical properties over time, poor dripping and poor reattachment due to insufficient adhesive strength, remaining plaster and redness / cattle / congestion due to excessive adhesive strength, decreased moisturizing effect, decreased transdermal absorbability of medicinal ingredients, bleed of oily components, etc. Tends to occur.

  For the purpose of introducing a crosslinked structure into the water-soluble polymer, the hydrogel is optionally sequestered and / or pH-adjusting agent as long as the effects of the present invention are not impaired. May further be included.

Examples of the sequestering agent include ethylenediaminetetraacetic acid, ethylenediaminetetraacetic acid disodium, ethylenediaminetetraacetic acid tetrasodium, trimetaphosphoric acid, sodium hexametaphosphate, sodium tripolyphosphate, and sodium tetrapolyphosphate. It may be only one type or a mixture of two or more types. Among these, disodium ethylenediaminetetraacetate is particularly preferable. The sequestering agent has a calcium carbonate-chelating power (CaCO ₃ C.Vmg / g) of 100 or more mainly from the viewpoint of inhibiting the action of divalent metal ions. It is preferable. When the hydrogel contains the sequestering agent, the content thereof is preferably 0.005 to 1% by mass based on the mass of the entire base layer, and preferably 0.1 to 0. It is more preferable that it is 6 mass%. If the content of the sequestering agent is out of the above range, the base layer may be exuded from the backing layer (exudation) or tongue out (excess), the extensibility and workability at the time of manufacture will be reduced, or at the time of application And changes in physical properties during storage, dripping and poor reattachment due to insufficient adhesive strength, residual plaster due to excessive adhesiveness, redness, fogging, and congestion, decreased moisturizing effect, reduced transdermal absorbability of medicinal ingredients, oily components Bleed and the like tend to occur.

(Oil gel)
The oil gel according to the present invention is a gel using an oily component as a dispersion medium, and includes at least one selected from the group consisting of a polyhydric alcohol fatty acid ester and a fatty acid, and a dextrin fatty acid ester. It is a gel containing. The oil gel is preferably a structure in which a polyhydric alcohol fatty acid ester which is an oil component (oil component) and / or a dextrin fatty acid ester as a gelling agent is solubilized in a fatty acid.

  The oil gel according to the present invention contains at least one selected from the group consisting of the polyhydric alcohol fatty acid ester and the fatty acid, and among these, the cohesive strength, adhesive strength, adhesion, and use of the base layer It is more preferable that the polyhydric alcohol fatty acid ester is contained from the viewpoint that the feeling of use at the time tends to be more excellent.

  Examples of the polyhydric alcohol fatty acid ester according to the present invention include diglyceryl triisostearate, propylene glycol dicaprate, pentaerythritol tetra2-ethylhexanoate, propylene glycol monocaprylate, propylene glycol dicaprylate, and tri-2-ethylhexane. Trimethylolpropane triacid, trimethylolpropane triisostearate, glyceryl tri-2-ethylhexanoate, glyceryl tri (capryl-caprate), and 2-butyl-2-ethyl-1,3-propanediol 2-ethylhexanoate It may be mentioned, and only one of these or a mixture of two or more may be used. Among these, the polyhydric alcohol fatty acid ester is preferably glyceryl tri-2-ethylhexanoate. In addition, the glyceryl tri-2-ethylhexanoate has a saponification value (according to the saponification value test method of “Glyceryl Tri-2-ethylhexanoate” according to cosmetic varieties (Cosmetics Standards for Cosmetics)) of 340 to 370. The specific gravity (20 ° C.) is particularly preferably 0.949 to 0.959.

  As the fatty acid according to the present invention, those having 6 to 22 carbon atoms and 0 to 4 degrees of unsaturation are preferable. Examples of such fatty acids include caproic acid (6 carbon atoms, 0 degree of unsaturation), caprylic acid (8 carbon atoms, 0 degree of unsaturation), 2-ethylhexanoic acid (8 carbon atoms, 0 degree of unsaturation). , Capric acid (10 carbon atoms, 0 degree of unsaturation), lauric acid (12 carbon atoms, 0 degree of unsaturation), myristic acid (14 carbon atoms, 0 degree of unsaturation), palmitic acid (16 carbon atoms, degree of unsaturation) 0), palmitoleic acid (16 carbon atoms, 1 degree of unsaturation), stearic acid (18 carbon atoms, 0 degree of unsaturation), isostearic acid (18 carbon atoms, 0 degree of unsaturation), hydroxystearic acid (18 carbon atoms, Unsaturation degree 0), oleic acid (carbon number 18, unsaturation degree 1), linoleic acid (carbon number 18, unsaturation degree 2), linolenic acid (carbon number 18, unsaturation degree 3), arachidonic acid (carbon number) 20, degree of unsaturation 4), and behenic acid (22 carbon atoms) Degree of unsaturation 0). These may be mixtures of these or two or more kinds thereof may be only one of. Among these, the fatty acid is more preferably oleic acid and / or capric acid, and even more preferably oleic acid.

  Content of the polyhydric alcohol fatty acid ester and / or the fatty acid (in the case where any one of the polyhydric alcohol fatty acid ester and the fatty acid is contained, the content thereof is a mixture of two or more kinds) Is the total content thereof, the same shall apply hereinafter), preferably 20-30% by mass, more preferably 20-28% by mass, more preferably 21-28, based on the mass of the whole base layer. It is more preferable that it is mass%, and it is especially preferable that it is 21-25 mass%. When the content of the polyhydric alcohol fatty acid ester and / or the fatty acid is less than the lower limit, the skin moisturizing effect and the skin protective effect tend to be lowered. On the other hand, when the content exceeds the upper limit, Adhesive strength, cohesive strength, shape retention, water absorption ability, etc. are reduced, the base layer becomes non-uniform, the base layer's backing stain (exudation) and tongue sticking (extruding), oily components Bleeding, spreadability and workability at the time of manufacture, use feeling and skin moisturizing effect at the time of use, skin safety, and percutaneous absorbability of medicinal ingredients are likely to occur. .

  Examples of the dextrin fatty acid ester according to the present invention include dextrin palmitate, dextrin palmitate / octanoate, dextrin (palmitate / ethylhexanoate), and dextrin myristate. Or it may be a mixture of two or more. Among these, the dextrin fatty acid ester is preferably at least one selected from the group consisting of dextrin palmitate, (palmitic acid / ethylhexanoic acid) dextrin, and dextrin myristic acid. It is particularly preferred to use in Further, the dextrin palmitate preferably has an acid value (according to the acid value test method of “dextrin palmitate”, “drug additive standard” “dextrin palmitate”) of 38 or less, and more preferably 10 or less. . Furthermore, as said dextrin palmitate, it is preferable that melting | fusing point (according to medicine supplement "dextrin palmitate" confirmation test (3)) is 50-63 degreeC. If the acid value or the melting point is out of the above range, the oily component may be bleed.

  The dextrin fatty acid ester according to the present invention preferably has a gel strength of 10 to 300 g, more preferably 30 to 250 g. In the present invention, the gel strength of dextrin fatty acid ester refers to a value obtained by the following gel strength test method. If the gel strength is out of the above range, bleeding of oily components may occur.

Gel strength test method 5 g of dextrin fatty acid ester is weighed in a flat bottom container having an inner diameter of 45 mm, and 45 g of liquid paraffin (# 70) is added and dispersed, and heated to 90 ° C. while gently stirring to dissolve. Immediately after that, it is allowed to stand for 24 hours in a thermostatic bath at 30 ° C. to form a gel. This gel is quickly set on a rheometer (SUN RHEO METER CR-200D / CR-500DX (manufactured by San Kagaku Co., Ltd.)) so as not to cause a temperature change, and the following conditions:
Temperature: 30 ° C
Adapter: Disk with a diameter of 20 mm and a thickness of 2 mm Mounting speed: 60 mm / min
Measure gel strength with. The initial peak, that is, the yield value (g) is taken as the gel strength.

  As content of the said dextrin fatty acid ester, it is preferable that it is 0.1-6 mass% on the basis of the mass of the whole said base layer, and it is more preferable that it is 0.2-4 mass%. When the content of the dextrin fatty acid ester is less than the lower limit, the viscosity of the base layer increases and becomes hard, adhesive strength, cohesive force, water absorption ability, etc. decrease, moisturizing effect and feeling during use. On the other hand, if the above upper limit is exceeded, the oily component cannot be sufficiently retained in the base, the oily component may bleed and the skin may become sticky, and the feeling of use during use tends to decrease. Tend to be.

  The oil gel has an oil component other than the polyhydric alcohol fatty acid ester and the fatty acid, and / or a gelling agent other than the dextrin fatty acid ester (sucrose fatty acid ester, organic, within a range not inhibiting the effects of the present invention. Pentonite etc.) may be further contained.

[Polymethyl acrylate / 2-ethylhexyl acrylate copolymer]
In the sheet-like pack agent of the present invention, the base layer contains a polymethyl acrylate / 2-ethylhexyl acrylate copolymer, so that an oil component, that is, mainly the polyhydric alcohol fatty acid ester and / or Or even when a large amount of the fatty acid is contained, pain at the time of peeling is sufficiently reduced and excellent base layer uniformity, cohesive strength, adhesive strength, and adhesion to the skin, and Excellent use feeling during use can be achieved.

  The polymethyl acrylate / acrylic acid 2-ethylhexyl copolymer according to the present invention is a copolymer of methyl acrylate and 2-ethylhexyl acrylate. The polymethyl acrylate / acrylic acid 2-ethylhexyl copolymer has a viscosity of 100 to 500 mPa · S in a 56 to 60% by mass aqueous solution (aqueous emulsion, pH 2 to 3, temperature 25 ° C.). Preferably, it is 250 to 450 mPa · S.

  The content of the polymethyl acrylate / 2-ethylhexyl acrylate copolymer needs to be 1.77 to 5.90 mass% based on the mass of the entire base layer. Moreover, as said content, it is more preferable that it is 2.0-5.9 mass%, and it is especially preferable that it is 2.5-5.0 mass%. Furthermore, the mass ratio of the content of the polyhydric alcohol fatty acid ester and / or the fatty acid in the base layer to the content of the polymethyl acrylate / 2-ethylhexyl acrylate copolymer is 3.3: 1. -17.0: 1 is preferable, 3.4: 1 to 16.9: 1 is more preferable, and 3.5: 1 to 16.5: 1 is more preferable. When the content of the polymethyl acrylate / 2-ethylhexyl acrylate copolymer is less than the lower limit, the adhesive strength, cohesive force, shape retention, water absorption ability of the base layer are reduced, and Non-uniformity, spreadability and workability during production, use feeling during use, moisturizing effect, and transdermal absorbability of medicinal components are reduced. On the other hand, when the content exceeds the upper limit, the viscosity of the base layer increases, the base layer becomes non-uniform, the extensibility and workability at the time of manufacture, the feeling of use at the time of use, the medicinal effect Reduces transdermal absorbability of ingredients and skin safety.

  In the present invention, the polymethyl acrylate / 2-ethylhexyl acrylate copolymer is preferably blended in the form of an aqueous emulsion dispersed in water during the production of the sheet-like pack agent. The aqueous emulsion preferably further contains a surfactant and / or a protective colloid agent in addition to water and a polymethyl acrylate / 2-ethylhexyl acrylate copolymer. As the colloid agent, poly (oxyethylene) nonylphenyl ether is preferred. Therefore, the base layer according to the present invention may further contain a surfactant and / or a protective colloid agent derived from the emulsion. When the surfactant and / or the protective colloid agent (preferably, poly (oxyethylene) nonylphenyl ether) is further contained, the total content thereof is 0. 0 based on the mass of the entire base layer. It is preferable that it is 05-0.3 mass%.

[Other ingredients]
As the base layer according to the present invention, at least one selected from the group consisting of polyglycols and polyhydric alcohols (hereinafter referred to as “polyglycols and / or in some cases” within a range not inhibiting the effects of the present invention. Or “polyhydric alcohols”). By further containing the polyglycols and / or polyhydric alcohols, in addition to the water-soluble polymer and the crosslinking agent, the following moisturizing ingredients, skin-beautifying ingredients, preservatives, and the like can be dispersed and dissolved as necessary. The function as an agent or a plasticizer and the function of promoting the water release and volatilization can be expected.

  In the present invention, polyglycols refer to polyglycols having a weight average molecular weight (polystyrene conversion) of 200 or more by gel permeation chromatography (GPC). As the polyglycols, those having a polyether structure such as polyethylene glycol and polypropylene glycol are preferable, polyethylene glycol having a weight average molecular weight of 200 to 600, and polypropylene glycol having a weight average molecular weight of 500 to 3000 are particularly preferable. . These polyglycols have low hydrophilicity due to a small proportion of hydroxyl groups compared to the following low molecular weight polyhydric alcohols, and are low in hydrophilicity, and reduce the critical relative humidity of the base layer components excluding water. More water can be discharged to the outside. As a result, the skin can be moisturized and the heat of vaporization caused by the volatilization of water can suppress the burning and inflammation of the face and give a pleasant refreshing feeling.

  In the present invention, polyhydric alcohols refer to polyols having a molecular weight of less than 200. Examples of the polyhydric alcohols include low molecular weight polyhydric alcohols having 2 to 3 hydroxyl groups in one molecule, among which a group consisting of propylene glycol, 1,3-butylene glycol, glycerin, and concentrated glycerin. It is preferable that it is at least 1 type selected from. Since these polyhydric alcohols have high hydrophilicity and increase the critical relative humidity of the base layer component excluding water, the release and volatilization of water can be further suppressed during use.

  When the base layer further contains the polyglycols and / or the polyhydric alcohols, the content thereof (in the case of containing any one of the polyglycols and the polyhydric alcohols) In the case where the content is a mixture of two or more, the total content thereof, the same shall apply hereinafter) is preferably 5 to 50% by mass based on the mass of the whole base layer, and 10 to 30 More preferably, it is mass%. When the content is less than the lower limit, the adhesive strength and cohesive strength of the base layer are reduced, the water retention and the shape retention are reduced, the base layer is not uniform, the workability during production is reduced, and when used Decrease in feeling of use, decrease in moisturizing effect, decrease in transdermal absorbability of medicinal components, bleeding of oily components, etc., on the other hand, if the above upper limit is exceeded, the adhesive strength of the base layer, There is a tendency that the cohesive force and the shape retention are likely to be lowered. By adjusting the blending balance of these polyglycols and / or polyhydric alcohols and the water, it is possible to control more appropriate moisture retention and adhesiveness to the skin.

  Further, in the base layer according to the present invention, preservatives, medicinal ingredients, skin-beautifying ingredients, moisturizing ingredients, antioxidants, dissolution, depending on the use of the sheet-like pack agent, within the range not inhibiting the effects of the present invention. An appropriate amount of an agent, a pigment, a fragrance, a surfactant, an ultraviolet absorber, an inorganic filler, a cooling sensation imparting component, a warming sensation imparting component, a pH adjuster, and the like can be appropriately contained.

  Examples of the preservative include paraoxybenzoic acid esters (eg, methylparaben, ethylparaben, propylparaben), 1,2-pentanediol, benzoic acid, benzoate, salicylate, sorbic acid, sorbate, dehydroacetic acid Salt, 4-isopropyl-3-methylphenol, 2-isopropyl-5-methylphenol, phenol, hinokitiol, cresol, 2,4,4′-trichloro-2′-hydroxydiphenyl ether, 3,4,4′-trichlorocarba Nido, chlorobutanol, benzalkonium chloride, benzethonium chloride and the like can be mentioned, and only one of them or a mixture of two or more thereof may be used. Of these, paraoxybenzoic acid esters are preferred as the preservative.

  The medicinal component is not particularly limited as long as it is a transdermally absorbable drug. For example, prednisolone, dexamethasone, hydrocortisone, fluocinolone acetonide, betamethasone valerate, betamethasone dipropionate, clobetasone butyrate, succinic acid Steroidal anti-inflammatory agents such as prednisolone; methyl salicylate, glycol salicylate, indomethacin, ketoprofen, diclofenac, ibuprofen, flurbiprofen, felbinac, ketorolac, loxoprofen, suprofen, pranoprofen, thiaprofen, flufenamic acid, tenidap, aspirin, actarit Non-steroidal anti-inflammatory agents such as mizoribine, oxaprozin, mofezolac, etodolac, auranofin, indomethacin funnelsil Ester derivatives: anti-allergic agents such as tranilast, azelastine, ketotifen, ibudilast, oxatomide, emedastine, epinastine; antihistamines such as diphenhydramine, chlorpheniramine, promethazine, tripelamine; chlorpromazine, nitrazepam, diazepam, phenobarbital Agonists.

  Examples of the medicinal ingredients include hormones such as insulin, testosterone, norethisterone, methyltestosterone, progesterone, and estradiol; antihypertensive agents such as clonidine, reserpine, guanethidine sulfate, efonidipine, alprenolol, and nifedipine; digitoxin, digoxin, and the like Anti-arrhythmic agents such as propranolol hydrochloride, procainamide hydrochloride, ajmarin, pindolol, and tulobuterol hydrochloride; coronary vasodilators such as nitroglycerin, isosorbide nitrate, papaverine hydrochloride, nifedipine, diltiazem, and nicorandil; lidocaine, procaine, Local anesthetics such as procaine hydrochloride, benzocaine, tetracaine; analgesics such as morphine, aspirin, codeine, acetanilide, aminopyrine; tizanidine Muscle relaxants such as eperisone, tolperisone, inaperisone, dantrolene; antifungal agents such as acetophenylamine, nitrofurazone, pentamycin, naphthomate, miconazole, omoconazole, clotrimazole, butenafine hydrochloride; 5-fluorouracil, busulfan, actinomycin, pleio Antineoplastic agents such as mycin and mitomycin; Urinary incontinence agents such as terridine hydrochloride and oxybutynin hydrochloride; Antiepileptic agents such as nitrazepam and meprobamate; Antiparkinson agents such as chlorzoxazone, levodopa, amantadine, selegiline hydrochloride, ranolazine hydrochloride and ropinirole hydrochloride Antiemetics such as granisetron, azasetron, ondansetron, ramosetron; frequent urine treatments such as oxybutynin; Ca antagonists such as nifedipine; Le, morphine, psychotropic drugs such Imibiramin; diphenidol, antivertigo agents such as betahistine; benzothiazepine etc. Cardiovascular drugs; ketotifen, tulobuterol, also include antitussive 疲剤 such tranilast.

  Furthermore, as the medicinal component, cerebral circulation improving agents such as vinpocetine, nicergoline, nicorandil, clentiacem maleate, fasudil hydrochloride, benidipine hydrochloride, efonidipine hydrochloride; cerebrovascular dementia agents such as docosahexaenoic acid, vinconate hydrochloride, nebracetam fumarate; Alzheimer's therapeutic agents such as donepezil hydrochloride, amyridine hydrochloride, memantine hydrochloride; polypeptide hormones such as ruinizing hormone-releasing hormone and thyrotropin releasing hormone; immunomodulation of polysaccharides, auranofin, lobenzarit, etc. Agents; diuretics such as hydroflumethiazide; diabetic agents such as tolbutamide; anti-gout agents such as colchicine; smoking cessation aids such as nicotine; vitamins; Jin class; excitement stimulant; hypnotic sedative; autonomic agents, peripheral vasodilators may also be mentioned.

Examples of the medicinal ingredients include diphenhydramine hydrochloride, diphenhydramine salicylate, diphenhydramine tannate, triprolidine hydrochloride, mequitazine, chlorpheniramine maleate, chlorpheniramine maleate, clemastine fumarate, promethazine hydrochloride, tranilast, sodium cromoglycate , Ketotifen, allylsulfatase B, bufexamac, pendazac, butyl flufenamate, ibuprofen, indomethacin, aspirin, flurbiprofen, ketoprofen, piroxicam, 2-pyridinemethylmefenamic acid, 5,6-dehydroarachidonic acid, 5,6 -Methano-LTA ₄ , esculetin, eupatirin, 4-demethyl eupatilin, caffeic acid, benoxaprofen, arbutin, α- Drugs having a whitening action such as arbutin and β-arbutin (4-hydroxyphenyl-β-D-glucopyranoside); drugs having an antioxidative action such as α-lipoic acid, ubidecarenone and polyphenol are also included. The medicinal component may be only one of the above or a mixture of two or more.

  Examples of the beautifying skin component include allantoin; glycyrrhizic acid; dipotassium glycyrrhizinate; papain enzyme; amino acids such as L-arginine; arbutin; flavonoids; collagen; yogurt extract; lecithin; Placenta extracts such as water-soluble placenta extract; silk or silk extract; extracts from various herbal medicines such as aloe, loofah and licorice and Japanese and Han plants; ashitaba extract, asparagus sarius extract, asenyaku extract, avocado extract, achacha Extract, armature extract, altea extract, arnica extract, almond extract, aloe extract, anthracnose extract, izayoi rose extract, itadori extract, ginkgo biloba extract, nettle extract, iris root extract, oolong tea extract , Fennel extract, turmeric extract, ages extract, sorghum leaf extract, echinacea leaf extract, pea extract, dragonfly moth, peony extract, laurel extract, giant thistle extract, giant beetle extract, barley extract, barley fermented extract, okra extract, hypericum extract, Odori extract, Ononis extract, Dutch mustard extract, orange extract, orange flower water, seaweed extract, oyster tannin, cuckoo extract, valerian extract, gama extract, chamomile extract, chamomile water, oat extract, quince extract, carrot extract, kawara mugwort extract, licorice extract Liquid, raspberry extract, ginnan extract, vanapa tea extract, enju extract, buckwheat extract, neroli extract, magnolia extract, chickpea Extract, hibiscus extract, bilberry extract, cod extract, guavafenone, kujin, nogate tou, mucuna extract, melosria extract, lily bulb extract, raspberry extract, lumpuyan, green tea extract, apple phenon, touki extract, apricot extract, tea tree extract, peach extract, Macadamia oil, Almond oil, Kiwi extract, Kina extract, Cucumber extract, Kyonin extract, Quince seed extract, Gardenia extract, Kumazasa extract, Cumin extract, Clara extract, Walnut shell extract, Grapefruit extract, Clematis extract, Chlorella extract, Mulberry extract, Mulberry leaf Extract, Caquette extract, Keihi extract, Gentian extract, Gennoshoco extract, Kemponashi extract, Coffee Kiss, black tea extract, citrus extract, burdock extract, wheat germ extract, rice bran extract, rice bran extract, comfrey extract, saicin extract, saffron extract, savanna extract, hawthorn extract, salamander extract, shiitake extract, shiitake extract, shikon extract, perilla extract , Linden extract, citrus extract, peony extract, juzudama extract, ginger extract, ginger root extract, birch extract, birch sap, honeysuckle extract, horsetail extract, stevia extract, sage extract, sage water, squirrel extract, hawthorn extract, Elderberry extract, Apricot extract, Achillea millefolium extract, Acacia mint extract, Zeni mallow extract, Celery extract, Senkyu extract, Sen Agate water extract, soybean extract, peanut extract, thyme extract, tea extract, tea fruit extract, clove extract, chorei extract, chimpi extract, camellia extract, duckweed extract, duke extract, terminaria extract, tencha extract, red pepper extract, red pepper extract, Toki extract, Toki-Senka extract, Toki water, Cordyceps extract, Touninex, Spruce extract, Corn extract, Dokudami extract, Tomato extract, Tormentilla extract, Natto extract, Carrot extract, Garlic extract, Novara extract, Bakuga extract, Bakuga root extract, Baku Mondo extract, parsley extract, distilled mint water, Hamanashi extract, Hamamelis extract, Hamamelis extract, Rose extract, Parietalia extract, Toad extract, Hinoki water, Bi Kudan extract, loquat leaf extract, dandelion extract, buccal extract, butcher bloom extract, grape extract, grape water, grape leaf extract, beech extract, prune extract, hay flower extract, loofah extract, loofah water, safflower extract, button extract, hop extract, Pine extract, pine licorice extract, maria thistle extract, maronnier extract, mugwort extract, purple clover extract, muraya coconut extract, melissa extract, merirot extract, peach leaf extract, coconut extract, cornflower extract, cornflower water, eucalyptus extract, eucalyptus water, yukinoshita Extract, Yuzu Extract, Lily Extract, Yokuinin Extract, Artemisia Extract, Artemisia Water, Lavender Extract, Lavender Water, Cyanobacteria Extract, Apple Extract, Apple Water, Ganoderma Extract , Botanical extracts such as lettuce extract, lemon extract, lotus extract, rosemary extract, rosemary water, rose water, roman chamomile extract, logwood extract, bitumen extract, evening primrose seed extract, evening primrose extract; vitamin A, vitamin C , Vitamin D, vitamin E and other vitamins; vitamin C derivatives such as magnesium ascorbate phosphate, sodium ascorbate phosphate, ascorbyl 2-glucoside, ascorbyl tetrahexyldecanoate (ascorbyl tetraisopalmitate), etc. And may be one of these or a mixture of two or more.

  Examples of the moisturizing component include succinyl kefiran aqueous solution, acetyl kefiran aqueous solution, maleyl kefiran aqueous solution, malt root extract, age extract, orange extract, orange juice, kistrawberry extract, kiwi extract, cucumber extract, grapefruit extract, hawthorn extract, Salamander extract, Atlantic hawthorn extract, Atlantic rat extract, Atlantic extract, jujube extract, Duke extract, tomato extract, grape extract, loofah extract, lime juice, apple extract, apple juice, lemon extract, lemon juice, etc. Only one of them or a mixture of two or more may be used. Of these, the plant extract can also be used as the skin beautifying component, and the fruit juices can be used as the following fragrances.

  Examples of the antioxidant include ascorbic acid, propyl gallate, butylhydroxyanisole, dibutylhydroxytoluene, nordihydroguaiaretic acid, tocopherol, tocopherol acetate, sodium bisulfite, and the like. It may be a mixture of two or more.

  Examples of the solubilizer include benzyl alcohol, pyrothiodecane, mint oil, isopropyl myristate, crotamiton, pyrrolidones such as N-methyl-2-pyrrolidone, higher alcohols, diethyl adipate, isopropyl adipate, diisopropyl adipate, Polybasic acids such as diisobutyl adipate, dioctyl adipate, di (2-heptylundecyl) adipate, diisopropyl sebacate, diethyl sebacate and the like can be mentioned. It may be a mixture.

  Examples of the dye include Red No. 2 (Amaranth), Red No. 3 (Erythrosin), Red No. 102 (New Coxin), Red No. 104 (1) (Phloxine B), Red No. 105 (1) ( Rose Bengal), Red 106 (Acid Red), Yellow 4 (Tartrazine), Yellow 5 (Sunset Yellow FCF), Green 3 (Fast Green FCF), Blue 1 (Brilliant Blue FCF), Blue 2 Legal pigments such as (Indigo Carmine) can be mentioned, and only one of them or a mixture of two or more thereof may be used.

  Examples of the surfactant include anionic surfactants such as sodium dioctylsulfosuccinate, alkyl sulfate salt, sodium 2-ethylhexylalkyl sulfate, sodium normal dodecylbenzenesulfonate; hexadecyltrimethylammonium chloride, octadecyldimethylbenzylammonium chloride , Cationic surfactants such as polyoxyethylene dodecyl monomethyl ammonium chloride; polyoxyethylene (20) hydrogenated castor oil, polyoxyethylene (30) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene ( 50) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil, polyoxyethylene (80) hydrogenated castor oil, polyoxyethylene (100) hydrogenated castor oil, Sorbitan nooleate, sorbitan sesquioleate, sorbitan trioleate, polyoxyethylene stearyl ether, polyoxyethylene tridecyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, polyoxyethylene monostearate, sorbitan mono Nonionic surface activity such as stearate, sorbitan monopalmitate, sorbitan sesquioleate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate, glycerol monostearate, polyglycerin fatty acid ester, polyoxyethylene octadecylamine An agent may be mentioned, and only one of them or a mixture of two or more may be used.

  Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid ester, amyl paradimethylaminobenzoic acid, salicylic acid ester, menthyl anthranilate, umbelliferone, esculin, benzyl cinnamate, cinoxalate, guaiazulene, urocanic acid, 2- (2-hydroxy-5-methylphenyl) benzotriazole, 4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone, dioxybenzone, octabenzone, dihydroxydimethoxybenzophenone, soribenzone, benzoresorcinol, octyldimethylparaaminobenzoate, ethylhexylparamethoxy Cinamate etc. are mentioned, and it may be only one of these or a mixture of two or more.

  Examples of the inorganic filler include titanium oxide, zinc oxide, hydrous silica, magnesium carbonate, calcium hydrogen phosphate, magnesium silicate, hydrous magnesium silicate, diatomaceous earth, anhydrous silicic acid, pentonite, and the like. Or a mixture of two or more.

  Examples of the cooling sensation-imparting component include terpene hydrocarbon compounds, menthol-related compounds, and the like. Specifically, P-menthane such as limonene, terpinolene, menthane, terpinene, and monocyclic derivatives derived therefrom. Monoterpene hydrocarbon compounds: l-menthol, d-menthol, dl-menthol, isopulegol, 3,1-methoxypropane-1,2-diol, 1- (2-hydroxyphenyl) -4- (3-nitrophenyl ) -1,2,3,6-tetrahydroxypyrimidin-2-one, ethylmenthane carboxamide, p-menthane-3,8-diol, 3,8-dihydroxy-p-menthane-3-9-diol, trialkyl Substituted cyclohexanecarboxyamide and the like. Even if only one of these is used, two or more It may be a mixture of.

  Capsaicin analogs such as capsaicin, capsaicinoid, dihydroxycapsaicin, capsanthin; capsicoside, capsicum extract, capsicum tincture, capsicum powder, etc .; benzyl nicotinate; β-butoxyethyl nicotinate: N -Acyl vanilamide: Nonyl acid vanilamide and the like may be mentioned, and only one of them or a mixture of two or more may be used.

  Examples of the pH adjuster include acetic acid, formic acid, lactic acid, tartaric acid, oxalic acid, benzoic acid, glycolic acid, malic acid, citric acid, hydrochloric acid, nitric acid, sulfuric acid, sodium hydroxide, potassium hydroxide, methylamine, ethylamine, propyl Amine, dimethylamine, diethylamine, dipropylamine, trimethylamine, triethylamine, tripropylamine, monomethanolamine, monoethanolamine, monopropanolamine, dimethanolamine, diethanolamine, dipropanolamine, trimethanolamine, triethanolamine, triethanolamine A propanolamine etc. are mentioned, Only 1 type of these may be sufficient, and 2 or more types of mixtures may be sufficient. The pH of the base layer is 4 to 8 from the viewpoints of the spread state at the time of manufacture, the spreadable time, safety such as skin irritation, moisturizing effect, transdermal absorbability, and suppression of bleeding of oily components. It is preferable that it is 5-7.

[Method for producing sheet-shaped pack]
Subsequently, the manufacturing method of the sheet-like pack agent of this invention is demonstrated. The sheet-like pack agent of the present invention can be produced by appropriately adopting a known method for producing a sheet-like pack agent. In particular, the sheet-like pack agent of the present invention having a uniform base layer can be obtained. From the viewpoint of being able to produce, the manufacturing method of the following sheet-like pack agent of the present invention:
A method for producing a sheet-like pack comprising a support layer and a base layer,
A step of obtaining an oil gel containing at least one selected from the group consisting of a polyhydric alcohol fatty acid ester and a fatty acid, and a dextrin fatty acid ester;
Mixing the oil gel, polymethyl acrylate / acrylic acid 2-ethylhexyl copolymer, and water to obtain an oil gel composition;
Mixing the oil gel composition with a water-soluble polymer and a crosslinking agent to obtain a mixed composition; and
A hybrid gel in which the water gel is cross-linked, and the oil gel is included in a hydrogel containing the water-soluble polymer, the water and the cross-linking agent; and the polymethyl acrylate and 2-ethylhexyl polyacrylate A step of obtaining a base layer containing a copolymer, and
The content of the polymethyl acrylate / 2-ethylhexyl acrylate copolymer in the base layer is 1.77 to 5.90% by mass,
It is preferable to obtain by a manufacturing method.

  The support layer, the base layer, the polyhydric alcohol fatty acid ester, the fatty acid, the dextrin fatty acid ester, the oil gel, the polymethyl acrylate / 2-ethylhexyl acrylate copolymer, the water-soluble polymer, the The water, the cross-linking agent, the hydrogel, and the hybrid gel are as described in the sheet-like pack agent of the present invention.

  In the production method of the present invention, as the step of obtaining the oil gel, the polyhydric alcohol fatty acid ester and / or fatty acid and the dextrin fatty acid ester are mixed, and more specifically, the polyhydric alcohol fatty acid ester and / or Alternatively, the fatty acid is used as a dispersion medium, and the dextrin fatty acid ester is dispersed and stirred while heating until uniform, then returned to room temperature and the oil gel from the polyhydric alcohol fatty acid ester and / or fatty acid and the dextrin fatty acid ester. Is preferably formed. The heating temperature at this time is preferably 60 to 100 ° C. In this step, the oil gel is formed by crystallization of the long-chain alkyl group in the polyhydric alcohol fatty acid ester and / or fatty acid, and the dextrin fatty acid ester, and hydrogen bonding between the hydroxyl groups in the dextrin fatty acid ester. The

  As the step of obtaining the oil gel composition, first, the polymethyl acrylate / 2-ethylhexyl acrylate copolymer and the polymethyl acrylate / 2-ethylhexyl acrylate copolymer emulsion containing water are prepared and necessary. And further adding the sequestering agent and / or the pH adjuster, etc., and then mixing this with the oil gel, the oil gel, the polymethyl acrylate / 2-ethylhexyl acrylate copolymer, It is preferable to obtain an oil gel composition containing water.

  The polymethyl acrylate / acrylic acid 2-ethylhexyl copolymer emulsion is an aqueous solution further containing a surfactant and / or a protective colloid agent in addition to water and polymethyl acrylate / 2-ethylhexyl acrylate copolymer. An emulsion is preferred, and the surfactant and protective colloid agent are preferably the poly (oxyethylene) nonylphenyl ether. In the aqueous emulsion, the content of the polymethyl acrylate / 2-ethylhexyl acrylate copolymer is preferably 57 to 61% by mass. When the surfactant and / or the protective colloid agent (preferably, poly (oxyethylene) nonylphenyl ether) is further contained, the total content thereof is 2.0 to 3. It is preferably 0% by mass. As such a polymethyl acrylate / 2-ethylhexyl acrylate copolymer emulsion, for example, a commercially available product such as “Nicazole TS-620 (manufactured by Nippon Carbide Industries, Ltd.)” can be used.

  In the production method of the present invention, as the step of obtaining the mixed composition, the oil gel composition, the water-soluble polymer, and the crosslinking agent are mixed. At this time, after previously obtaining the hydrogel composition in which the water-soluble polymer and the crosslinking agent are mixed with water and the water-soluble polymer and the crosslinking agent are uniformly dispersed and dissolved in the water. The hydrogel composition and the oil gel composition may be mixed. Further, in the production method of the present invention, as the water, the total amount contained in the obtained base layer may be added at once in the step of obtaining the oil gel composition, or in the step of obtaining the oil gel composition. A part may be added and the rest may be added in the step of obtaining the mixed composition.

  As the mixing method, for example, the oil gel composition, the water-soluble polymer, water, and the cross-linking agent (or the hydrogel composition) are stirred and dispersed or dissolved until they are uniform. It is preferable to obtain In the stirring, it is preferable to use a high-viscosity squeezing machine for high viscosity such as a Henschel mixer or a low-speed squeezing machine for high viscosity such as a planetary kneader. In this step, a pseudo-crosslinked body of the water-soluble polymer and the oil gel is formed by hydrogen bonding or hydrophobic bonding.

  In the production method of the present invention, as the step of obtaining the base layer, first, the water-soluble polymer in the mixed composition is crosslinked by time-reactive crosslinking with the crosslinking agent to form the water-soluble polymer, Forming a hydrogel containing water and the cross-linking agent, enclosing the oil gel in a three-dimensional network space of the hydrogel, and enclosing the oil gel in the hydrogel, and the polyacrylic acid It is preferable to obtain a base layer composition containing methyl acrylate 2-ethylhexyl copolymer. As a crosslinking condition at this time, it is preferable that the mixed composition is allowed to stand at a temperature of 10 to 50 ° C. for 1 to 30 days.

  As the step of obtaining the base layer, then, after applying the base layer composition to a predetermined thickness on one surface of the support layer, by cutting into a desired shape as necessary, It is preferable to obtain the base layer disposed on one surface of the support layer. In the application, for example, a doctor blade type spreader or a roll coater type spreader is preferably used.

  Further, when the sheet-like pack agent of the present invention further includes the release liner, in the step of obtaining the base layer, the step of bonding the release liner on the surface of the base layer opposite to the support layer. May further be included. In addition, as the step of obtaining the base layer, after obtaining the base layer composition, the base layer composition is applied to one surface of the release liner with a predetermined thickness to form a base layer. After forming, the support layer is bonded on the surface of the base layer opposite to the release liner, and cut into a desired shape as necessary, so that the support layer is separated from the release liner. You may obtain the said base layer arrange | positioned.

  Furthermore, as the step of obtaining the base layer, first, the mixed composition is applied on one surface of the support layer (or the release liner) with a predetermined thickness, and then the crosslinking conditions similar to the above are applied. The water-soluble polymer is crosslinked by time-reactive crosslinking with the crosslinking agent to form a hydrogel containing the water-soluble polymer, the water and the crosslinking agent, and a three-dimensional network space of the hydrogel The base layer containing the hybrid gel in which the oil gel is included in the hydrogel and the polymethyl acrylate / 2-ethylhexyl acrylate copolymer may be obtained. . At this time, when the release liner is further bonded (or when the support layer is bonded), the bonding may be performed before or after the crosslinking.

  Further, in the present invention, the obtained sheet-like pack agent is a hermetically sealed bag or container (for example, aluminum) from the viewpoints of prevention of contamination during storage, suppression of reduction of effects due to evaporation of volatile substances, and the like. It may be enclosed in a laminate bag) to form a package.

  EXAMPLES Hereinafter, although this invention is demonstrated more concretely based on an Example and a comparative example, this invention is not limited to a following example.

Example 1
First, 20 parts by mass of polyhydric alcohol fatty acid ester (glyceryl tri-2-ethylhexanoate) and 2 parts by mass of dextrin fatty acid ester (dextrin palmitate) were mixed and dissolved at 60 to 100 ° C., then returned to room temperature and oil gel Formed. Next, 0.35 parts by mass of a sequestering agent, 0.2 parts by mass of a preservative, and 0.1 parts by mass of a pH adjuster are dissolved in 43.45 parts by mass of purified water (* 1). 3 parts by weight (polymethyl acrylate / 2-ethylhexyl acrylate copolymer: 1.77 parts by weight) of methyl / ethyl acrylate 2-ethylhexyl copolymer emulsion (Nicazole TS-620 (manufactured by Nippon Carbide Industries Co., Ltd.)) After mixing, the oil gel was further mixed and uniformly dispersed and dissolved to obtain an oil gel composition.

  Next, 6.5 parts by weight of a water-soluble polymer (polyacrylic acid partially neutralized product, neutralization degree: 50% (sodium salt)), 4.4 parts by weight of a crosslinking agent (aluminum metasilicate) was added to the oil gel composition. 0.4 parts by weight of magnesium and 4.0 parts by weight of synthetic aluminum silicate), 10 parts by weight of polyhydric alcohols and 10 parts by weight of polyglycols are added and mixed until uniform, and at 10-50 ° C. for 7 days. A base layer composition containing a hybrid gel in which the oil gel was included in the hydrogel was obtained by allowing to stand.

The base layer composition thus obtained was applied (spread) to 1000 g / m ² on one surface of a release liner (polyethylene terephthalate film) subjected to a release treatment to form a base layer. Then, after laminating a support layer (polyester nonwoven fabric) thereon, it was cut into a face shape to obtain a sheet-shaped pack agent laminated in the order of support layer / base layer / release liner. Table 1 shows the composition (base composition) of the base layer composition. In Table 1, the mass of purified water (* 1) does not include the mass of water contained in the polymethyl acrylate / 2-ethylhexyl acrylate copolymer emulsion (the same applies hereinafter).

(Examples 4-5 , 7-8 , 10-11 , Comparative Examples 1-8, 11-15 )
Each sheet-shaped pack was obtained in the same manner as in Example 1 except that the composition of the base layer composition (base composition) was changed to the composition shown in Table 1 below.

  For the sheet-like packs obtained in each of the examples and comparative examples, the base layer uniformity evaluation (manufacturing suitability evaluation), the base layer cohesive strength evaluation, the base layer adhesive strength evaluation, the base layer skin Evaluation of adhesion to the skin, evaluation of pain at the time of peeling, and evaluation of the feeling of use at the time of use were carried out by the following methods. The obtained results are shown in Tables 2 to 3 below.

<Evaluation of uniformity of base layer (production suitability evaluation)>
The ease with which the base layer composition is spread and the visual appearance of the obtained base layer are determined according to the following criteria:
A: Can be easily spread, and the obtained base layer is extremely uniform. B: Although the spread is possible, the obtained base layer has some unevenness. C: Can be spread. It was difficult, and evaluation was performed as the obtained base layer was not uniform.

<Cohesion force evaluation>
Evaluation was performed on the sheet-like pack agent in which the uniformity evaluation (manufacturing suitability evaluation) of the base layer was A. The release liner is peeled from the base layer, and the amount of the base layer remaining on the surface of the release liner after the peeling is visually determined according to the following criteria:
A: The base layer is not attached to the release liner surface at all. B: The base layer is slightly attached to the release liner surface (less than 10 area%).
C: The base layer is coherently broken, and a large amount of the base layer adheres to the surface of the release liner (10 area% or more)
According to the evaluation.

<Adhesive strength evaluation>
First, each sheet-shaped pack agent was cut out into a 25 mm × 90 mm rectangle and placed on a horizontal bottom portion under an inclined base made of a sine curve, and the release liner was removed to expose the base layer. Next, No. 10 steel ball (diameter 10/32 inch) was rolled on the inclined surface of the inclined table, and the distance (stop distance) until the ball stopped on the surface of the base layer was measured. The measurement was repeated three times, and the average value of the obtained stop distances was calculated as an evaluation value (unit: mm). In addition, for the case where the ball did not stop on the surface of the base layer, the value was “90 <(mm)”. It is recognized that the shorter the stopping distance, the better the adhesive strength of the base layer.

<Adhesion evaluation>
In the adhesive strength evaluation, the sheet-like pack agent whose stop distance was less than 90 mm was evaluated. For 6 subjects, any one sheet-like pack is applied to the face after bath washing for 30 minutes a day, and the adhesion to the skin is determined according to the following criteria:
5: Not peeled off even 30 minutes after the start of sticking 4: The edge of the sheet pack was peeled off 30 minutes after the start of sticking 3: 1/4 of the area of the sheet pack after 30 minutes from the start of sticking More than 1/2 is peeled off 2: More than 1/2 of the sheet-shaped pack agent is peeled off more than 1/2 of the area of the sheet-like pack 30 minutes after the start of application 1: Sheet-like pack 3 is released 30 minutes after the start of application Evaluation was performed according to peeling of / 4 or more. The average value of 6 persons of the obtained values was calculated and used as an evaluation value. In addition, it is recognized that evaluation is 3.0 or more and is accept | permitted as a sheet-like pack agent.

<Pain assessment during peeling>
In the adhesive strength evaluation, the sheet-like pack agent whose stop distance was less than 90 mm was evaluated. For 6 subjects, one of the sheet packs per day was applied to the face after washing after bathing for 30 minutes, and the pain when peeling from the skin was determined according to the following criteria:
5: I don't feel pain at all. 4: I can't say whether there is pain. 3: I feel a little pain. 2: I feel a little pain. The average value of 6 persons of the obtained values was calculated and used as an evaluation value. In addition, it is recognized that evaluation is 3.0 or more and is accept | permitted as a sheet-like pack agent.

<Evaluation of use>
In the adhesive strength evaluation, the sheet-like pack agent whose stop distance was less than 90 mm was evaluated. 6 subjects were asked to apply one sheet-like pack per day for 30 minutes on the face after washing their face after taking a bath, and the oil component remaining on the skin after peeling from the skin (of the oil component) Skin familiarity), respectively, the following criteria:
5: The oil component is familiar to the skin and feels that the oil component remains on the skin 4: The oil component is familiar to the skin and feels that the oil component remains slightly on the skin 3: The oil component to the skin 2: Feeling that there is not much oil component remaining in the skin 1: Evaluation was made according to the feeling that there was no oil component remaining in the skin. The average value of 6 persons of the obtained values was calculated and used as an evaluation value. In addition, it is recognized that evaluation is 3.0 or more and is accept | permitted as a sheet-like pack agent.

( Comparative Example 16 )
The same as Example 1 except that fatty acid (oleic acid) was used instead of the polyhydric alcohol fatty acid ester, and the composition of the base layer composition (base composition) was changed to the composition shown in Table 4 below. Thus, a sheet-like pack agent was obtained.

(Example 14)
A sheet-like pack agent in the same manner as in Example 1 except that dextrin myristate was used as the dextrin fatty acid ester and the composition of the base layer composition (base composition) was as shown in Table 4 below. Got.

(Example 15)
Example 1 except that dextrin (palmitic acid / ethylhexanoic acid) dextrin was used as the dextrin fatty acid ester, and the composition of the base layer composition (base composition) was as shown in Table 4 below. Thus, a sheet-like pack agent was obtained.

( Reference Example 1 )
Similar to Example 1 except that fatty acid (capric acid) was used in addition to the polyhydric alcohol fatty acid ester, and the composition of the base layer composition (base composition) was changed to the composition shown in Table 4 below. Thus, a sheet-like pack agent was obtained.

Comparative Example 16, Example 1 4 to 1 5, and the sheet-like pack agent obtained in Reference Example 1, uniformity evaluation of base layer, the cohesive force of the base layer evaluation, adhesive strength evaluation of base layer, adhesion evaluation of skin base layer, peeling during pain evaluation, and feeling evaluation of the time of use (for feeling evaluation when using Comparative example 16 and example 1 4-15) was performed. In addition, in the sheet-like pack obtained in Reference Example 1 , for the evaluation of the adhesion of the base layer to the skin and the pain evaluation at the time of peeling, each evaluation was performed by pasting the sheet-like pack on the back of the hand instead of the face. Carried out. Table 4 below shows the results obtained together with the composition of each base layer composition (base composition). Moreover, in Table 4, each evaluation result and base composition in the sheet-like pack agent obtained in Example 4 are also shown as a reference.

As is apparent from the results shown in Tables 2 to 4, a sheet-shaped pack agent containing a specific amount of polymethyl acrylate / 2-ethylhexyl acrylate copolymer in the base layer (Examples 1 , 4, 5 , 7, 8, 10, 11, 14, 15, Comparative Examples 11 to 16, and Reference Example 1 ), the polyhydric alcohol fatty acid ester and / or the fatty acid is contained in a relatively large amount of 20% by mass or more. However, the base layer uniformity, cohesive strength, adhesive strength, and adhesion to the skin are all excellent in use feeling during use, and the pain during peeling should be sufficiently reduced. Was confirmed.

(Comparative Example 9)
Instead of the poly (methyl acrylate) / 2-ethylhexyl acrylate copolymer emulsion, aminoalkyl methacrylate copolymer E (Eudragit EPO (Evonik Industries AG)) was used, and the composition of the base layer composition (base composition) was as follows: A sheet-like pack agent was obtained in the same manner as in Example 1 except that the composition shown in Table 5 was obtained.

(Comparative Example 10)
Instead of poly (methyl acrylate) / 2-ethylhexyl acrylate copolymer emulsion, a methyl methacrylate / butyl methacrylate copolymer (Plastoid B (manufactured by Evonik Industries AG)) is used, and the composition of the base layer composition (base composition) ) Was obtained in the same manner as in Example 1 except that the composition shown in Table 5 below was obtained.

  About the sheet-like pack agent obtained in Comparative Examples 9-10, the uniformity evaluation (manufacturing appropriateness evaluation) of the said base layer was implemented. Table 5 below shows the results obtained together with the composition (base composition) of each base layer composition. Table 5 also shows the uniformity evaluation results and base composition of the sheet-like pack obtained in Example 10 as a reference.

  As is apparent from the results shown in Table 5, in place of polymethyl acrylate / 2-ethylhexyl acrylate copolymer, tackiness and molding, such as aminoalkyl methacrylate copolymer E and methyl methacrylate / butyl methacrylate copolymer, are used. Even when other conventionally known polymers are used as the polymer for imparting the property (Comparative Examples 9 to 10), it is confirmed that the relatively uniform polyhydric alcohol fatty acid ester is inferior in the uniformity of the base layer. It was.

  As described above, according to the present invention, even when a relatively large amount of the oil component is contained, the uniformity of the base layer, the cohesive strength, the adhesive strength, and the adhesion to the skin, and the use It is possible to provide a sheet-like pack agent that is excellent in the feeling of use at the time and sufficiently reduces the pain during peeling, and a method for producing the same.

Claims (2)

A sheet-like pack agent comprising a support layer and a base layer,
The base layer contains a hybrid gel in which an oil gel is included in a hydrogel, and a polymethyl acrylate / 2-ethylhexyl acrylate copolymer,
The hydrogel contains a water-soluble polymer, water and a crosslinking agent;
The oil gel comprises a polyhydric alcohol fatty acid ester le, which contains a dextrin fatty acid ester,
The content of the polyhydric alcohol fatty acid ester in the base layer is 20 to 28% by mass,
Ri The content of polyacrylic acid methyl 2-ethylhexyl acrylate copolymer is from 1.77 to 5.90% by mass in the base layer, and,
Mass ratio of content of polyhydric alcohol fatty acid ester and content of polymethyl acrylate / 2-ethylhexyl acrylate copolymer in the base layer (polyhydric alcohol fatty acid ester content: polymethyl acrylate) - the content of 2-ethylhexyl acrylate copolymer) is 20: 5.90 to 20: Ru 1.77 der,
A sheet-like pack agent characterized by the above. A method for producing a sheet-like pack comprising a support layer and a base layer,
Obtaining a polyhydric alcohol fatty acid ester le, a dextrin fatty acid ester, a oil gel containing,
Mixing the oil gel, polymethyl acrylate / acrylic acid 2-ethylhexyl copolymer, and water to obtain an oil gel composition;
Mixing the oil gel composition with a water-soluble polymer and a crosslinking agent to obtain a mixed composition; and
A hybrid gel in which the water gel is cross-linked, and the oil gel is included in a hydrogel containing the water-soluble polymer, the water and the cross-linking agent; and the polymethyl acrylate and 2-ethylhexyl polyacrylate A step of obtaining a base layer containing a copolymer,
The content of the polyhydric alcohol fatty acid ester in the base layer is 20 to 28% by mass,
Ri The content of polyacrylic acid methyl 2-ethylhexyl acrylate copolymer is from 1.77 to 5.90% by mass in the base layer, and,
Mass ratio of content of polyhydric alcohol fatty acid ester and content of polymethyl acrylate / 2-ethylhexyl acrylate copolymer in the base layer (polyhydric alcohol fatty acid ester content: polymethyl acrylate) - the content of 2-ethylhexyl acrylate copolymer) is 20: 5.90 to 20: Ru 1.77 der,
The manufacturing method of the sheet-like pack agent characterized by the above-mentioned.