CN115429715A - Hydrogels - Google Patents
Hydrogels Download PDFInfo
- Publication number
- CN115429715A CN115429715A CN202210402526.7A CN202210402526A CN115429715A CN 115429715 A CN115429715 A CN 115429715A CN 202210402526 A CN202210402526 A CN 202210402526A CN 115429715 A CN115429715 A CN 115429715A
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- Prior art keywords
- hydrogel
- component
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- content
- Prior art date
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- Pending
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- 239000000017 hydrogel Substances 0.000 title claims abstract description 114
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 21
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 229910052751 metal Inorganic materials 0.000 claims abstract description 9
- 239000002184 metal Substances 0.000 claims abstract description 9
- 229920006318 anionic polymer Polymers 0.000 claims abstract description 8
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- -1 fatty acid ester Chemical class 0.000 claims description 34
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 26
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 25
- 125000000129 anionic group Chemical group 0.000 claims description 24
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 15
- 239000000194 fatty acid Substances 0.000 claims description 15
- 229930195729 fatty acid Natural products 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 239000000178 monomer Substances 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 7
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 6
- 125000005456 glyceride group Chemical group 0.000 claims description 6
- 229920000570 polyether Polymers 0.000 claims description 6
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 5
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 5
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims description 5
- 150000001642 boronic acid derivatives Chemical class 0.000 claims description 5
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 239000004359 castor oil Substances 0.000 claims description 5
- 235000019438 castor oil Nutrition 0.000 claims description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 5
- 230000000379 polymerizing effect Effects 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 229920006243 acrylic copolymer Polymers 0.000 claims description 4
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 4
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 4
- 229920000223 polyglycerol Polymers 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 229930182478 glucoside Natural products 0.000 claims description 3
- 150000008131 glucosides Chemical class 0.000 claims description 3
- 239000007864 aqueous solution Substances 0.000 description 16
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 14
- 239000004480 active ingredient Substances 0.000 description 12
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 12
- 230000000052 comparative effect Effects 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- 229920002125 Sokalan® Polymers 0.000 description 9
- 229910052782 aluminium Inorganic materials 0.000 description 9
- 239000000499 gel Substances 0.000 description 9
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 229910021645 metal ion Inorganic materials 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 7
- 229910021538 borax Inorganic materials 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 7
- 235000010339 sodium tetraborate Nutrition 0.000 description 7
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 6
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 description 6
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 6
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 6
- 230000001815 facial effect Effects 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 5
- 239000004584 polyacrylic acid Substances 0.000 description 5
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 5
- 239000004328 sodium tetraborate Substances 0.000 description 5
- 239000013531 ACULYN rheology modifier Substances 0.000 description 4
- 235000011126 aluminium potassium sulphate Nutrition 0.000 description 4
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 230000003020 moisturizing effect Effects 0.000 description 4
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 4
- 229940077412 peg-12 laurate Drugs 0.000 description 4
- 229920001451 polypropylene glycol Polymers 0.000 description 4
- 229940050271 potassium alum Drugs 0.000 description 4
- 235000013772 propylene glycol Nutrition 0.000 description 4
- 238000007127 saponification reaction Methods 0.000 description 4
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 3
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 3
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 3
- WZUKKIPWIPZMAS-UHFFFAOYSA-K Ammonium alum Chemical compound [NH4+].O.O.O.O.O.O.O.O.O.O.O.O.[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O WZUKKIPWIPZMAS-UHFFFAOYSA-K 0.000 description 3
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 3
- 239000005977 Ethylene Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 3
- HDYRYUINDGQKMC-UHFFFAOYSA-M acetyloxyaluminum;dihydrate Chemical compound O.O.CC(=O)O[Al] HDYRYUINDGQKMC-UHFFFAOYSA-M 0.000 description 3
- 125000005250 alkyl acrylate group Chemical group 0.000 description 3
- 235000011124 aluminium ammonium sulphate Nutrition 0.000 description 3
- 229940009827 aluminum acetate Drugs 0.000 description 3
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 3
- 150000007942 carboxylates Chemical group 0.000 description 3
- 239000013043 chemical agent Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 238000001879 gelation Methods 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 description 3
- 238000006116 polymerization reaction Methods 0.000 description 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 description 3
- 229920001567 vinyl ester resin Polymers 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- CCLARULDIPFTCP-BOYHRMMASA-N (2r,3r,4r,5s)-heptane-1,2,3,4,5,6-hexol Chemical compound CC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CCLARULDIPFTCP-BOYHRMMASA-N 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- WAEMQWOKJMHJLA-UHFFFAOYSA-N Manganese(2+) Chemical compound [Mn+2] WAEMQWOKJMHJLA-UHFFFAOYSA-N 0.000 description 2
- LGRFSURHDFAFJT-UHFFFAOYSA-N Phthalic anhydride Natural products C1=CC=C2C(=O)OC(=O)C2=C1 LGRFSURHDFAFJT-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical group [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- 229940103272 aluminum potassium sulfate Drugs 0.000 description 2
- OJMOMXZKOWKUTA-UHFFFAOYSA-N aluminum;borate Chemical compound [Al+3].[O-]B([O-])[O-] OJMOMXZKOWKUTA-UHFFFAOYSA-N 0.000 description 2
- RJZNFXWQRHAVBP-UHFFFAOYSA-I aluminum;magnesium;pentahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Al+3] RJZNFXWQRHAVBP-UHFFFAOYSA-I 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 description 2
- 150000001844 chromium Chemical class 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 229910001430 chromium ion Inorganic materials 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 150000001991 dicarboxylic acids Chemical class 0.000 description 2
- 150000002009 diols Chemical class 0.000 description 2
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 150000002505 iron Chemical class 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 230000002427 irreversible effect Effects 0.000 description 2
- 150000002688 maleic acid derivatives Chemical class 0.000 description 2
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 2
- 150000002696 manganese Chemical class 0.000 description 2
- 239000011572 manganese Substances 0.000 description 2
- 229910001437 manganese ion Inorganic materials 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 239000011591 potassium Chemical group 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 125000000542 sulfonic acid group Chemical group 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 2
- 239000012498 ultrapure water Substances 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 description 1
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 1
- DEKFZWMENCCOFU-LIKAHPKFSA-N 2-[(2r)-2-[(2r,3s,4r)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOC[C@@H](OCCO)[C@H]1OC[C@@H](OCCO)[C@@H]1OCCO DEKFZWMENCCOFU-LIKAHPKFSA-N 0.000 description 1
- GDTSJMKGXGJFGQ-UHFFFAOYSA-N 3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound O1B([O-])OB2OB([O-])OB1O2 GDTSJMKGXGJFGQ-UHFFFAOYSA-N 0.000 description 1
- OFNISBHGPNMTMS-UHFFFAOYSA-N 3-methylideneoxolane-2,5-dione Chemical compound C=C1CC(=O)OC1=O OFNISBHGPNMTMS-UHFFFAOYSA-N 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 1
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
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- 229920002884 Laureth 4 Polymers 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- GRSMWKLPSNHDHA-UHFFFAOYSA-N Naphthalic anhydride Chemical compound C1=CC(C(=O)OC2=O)=C3C2=CC=CC3=C1 GRSMWKLPSNHDHA-UHFFFAOYSA-N 0.000 description 1
- OTRAYOBSWCVTIN-UHFFFAOYSA-N OB(O)O.OB(O)O.OB(O)O.OB(O)O.OB(O)O.N.N.N.N.N.N.N.N.N.N.N.N.N.N.N Chemical compound OB(O)O.OB(O)O.OB(O)O.OB(O)O.OB(O)O.N.N.N.N.N.N.N.N.N.N.N.N.N.N.N OTRAYOBSWCVTIN-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 229920001219 Polysorbate 40 Polymers 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- LWZFANDGMFTDAV-BURFUSLBSA-N [(2r)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O LWZFANDGMFTDAV-BURFUSLBSA-N 0.000 description 1
- FZQSLXQPHPOTHG-UHFFFAOYSA-N [K+].[K+].O1B([O-])OB2OB([O-])OB1O2 Chemical compound [K+].[K+].O1B([O-])OB2OB([O-])OB1O2 FZQSLXQPHPOTHG-UHFFFAOYSA-N 0.000 description 1
- 125000005396 acrylic acid ester group Chemical group 0.000 description 1
- 238000012644 addition polymerization Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 159000000013 aluminium salts Chemical class 0.000 description 1
- 229940009868 aluminum magnesium silicate Drugs 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
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- 229910052796 boron Inorganic materials 0.000 description 1
- JHIWVOJDXOSYLW-UHFFFAOYSA-N butyl 2,2-difluorocyclopropane-1-carboxylate Chemical compound CCCCOC(=O)C1CC1(F)F JHIWVOJDXOSYLW-UHFFFAOYSA-N 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
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- 230000005591 charge neutralization Effects 0.000 description 1
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- 229940071160 cocoate Drugs 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000005397 methacrylic acid ester group Chemical group 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical group CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 description 1
- PYUBPZNJWXUSID-UHFFFAOYSA-N pentadecapotassium;pentaborate Chemical compound [K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-] PYUBPZNJWXUSID-UHFFFAOYSA-N 0.000 description 1
- VPOLVWCUBVJURT-UHFFFAOYSA-N pentadecasodium;pentaborate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-].[O-]B([O-])[O-] VPOLVWCUBVJURT-UHFFFAOYSA-N 0.000 description 1
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- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229940043707 polyglyceryl-6 distearate Drugs 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229940101027 polysorbate 40 Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
- 229950006451 sorbitan laurate Drugs 0.000 description 1
- 235000011067 sorbitan monolaureate Nutrition 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- SRPWOOOHEPICQU-UHFFFAOYSA-N trimellitic anhydride Chemical compound OC(=O)C1=CC=C2C(=O)OC(=O)C2=C1 SRPWOOOHEPICQU-UHFFFAOYSA-N 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
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- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
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Abstract
The present invention provides a hydrogel comprising the following components (A), (B), (C) and (D): (a) an anionic polymer; (B) a trivalent metal salt and/or borate; (C) A nonionic surfactant having an IOB value of 0.1 or more and 2 or less; (D) water.
Description
Technical Field
The present invention relates to a hydrogel.
Background
In China, as more and more mask products are used, the cognition of consumers on the mask products gradually rises and the mask products are used as necessities for skin care.
The facial mask using the non-woven fabric soaked with the essence has a good skin care effect, but when the facial mask is used, the application position needs to be adjusted for many times in order to enable the facial mask to be applied to the face comfortably, and the facial mask is troublesome to use. In addition, as the essence must be exuded out of the non-woven fabric to achieve the skin care effect, the skin feel of the facial patches is very sticky and is a cause of scaling for consumers.
On the other hand, some gel-like facial mask materials are generally adapted to be applied only to a certain part of the face, such as the periphery of the eye. The material which can not change the shape is fixed, and the use requirements of consumers on variety and flexibility can not be met.
Therefore, consumers are urgently in demand for mask products which have a good use feeling, do not have the problems of dry feeling and sticky feeling, and maintain the original skin care function. Furthermore, the ground mask product can be conveniently applied to any position of the face.
Documents of the prior art
Patent document
Patent document 1: CN 110430859A
Patent document 2: CN 101002722A
Disclosure of Invention
In view of the above, an object of the present invention is to provide a hydrogel having excellent non-sticky feeling and non-dry feeling, and capable of realizing good feeling and feeling in use. Furthermore, the patch can be conveniently pasted on any position of the face.
The present inventors have found that by including a nonionic surfactant in a hydrogel, it is possible to improve the dry and astringent feeling and the sticky feeling, and that a hydrogel having no sticky feeling or dry and astringent feeling can be obtained when used on the skin.
The present invention provides a hydrogel comprising the following components (A), (B), (C) and (D):
(A) An anionic polymer;
(B) Trivalent metal salts and/or borates;
(C) A nonionic surfactant having an IOB value of 0.1 or more and 2 or less;
(D) And (3) water.
The inventors of the present invention have not clearly confirmed the mechanism by which the hydrogel of the present invention can realize excellent non-sticky feeling and non-dry and astringent feeling, but presume as follows: the main reason why the hydrogel exhibits dry feeling is the presence of trivalent metal ions or borate anions in the hydrogel, however, when a nonionic surfactant is included in the hydrogel, the oleophilic end of the surfactant exhibits excellent skin-affinity, thereby reducing the setback feeling due to the ions. On the other hand, the hydrogel shows oily and slippery feeling after the surfactant is added, thereby improving the sticky feeling.
In addition, the present invention also provides the use of the hydrogel as an external preparation for skin.
The present invention also provides a skin care method of applying the hydrogel of the present invention to skin.
Detailed Description
The following are detailed descriptions of the hydrogel of the present invention, its preparation method, and its use method.
< hydrogel >
[ component (A) ]
The component (A) used in the present invention is an anionic polymer which can form a large network structure with other ions by charge neutralization because of a certain number of polar groups contained in its molecular chain.
The anionic polymer of the component (a) may be 1 or 2 or more selected from the following components (A1), (A2) and (A3).
(A1) Anionic polyvinyl alcohol;
(A2) An acrylic copolymer obtained by polymerizing at least 1 monomer selected from acrylic acid, methacrylic acid, and alkyl acrylates having an alkyl group of 1 to 30 carbon atoms;
(A3) Carboxymethyl cellulose.
The carboxyl groups present in the components (A1), (A2), and (A3) are polar groups, and when other ions are present in the solution, the carboxyl groups are bonded to the other ions to form a three-dimensional network structure.
Component (A1)
The hydrogel of the present invention contains an anionic polyvinyl alcohol as the component (A1).
The component (A1) is, for example, polyvinyl alcohol having an anionic group such as a sulfonic acid group, a sulfuric acid group, a carboxyl group, a phosphoric acid group, or a phosphonic acid group.
From the viewpoint of suppressing a sticky feeling, the component (A1) is preferably a polyvinyl alcohol having at least one anionic group of a sulfonic acid group and a carboxyl group, and more preferably a polyvinyl alcohol having a carboxyl group.
In the present invention, an anionic group refers to an anionic group itself or a group capable of ionizing into an anionic group.
Examples of the polyvinyl alcohol having a carboxyl group include: (1) A product obtained by graft polymerization or block polymerization of polyvinyl alcohol and an unsaturated monomer having a carboxyl group; (2) A product obtained by copolymerizing a vinyl ester compound with an unsaturated monomer having at least one group selected from a carboxyl group and a carboxylate group and then saponifying the resultant; (3) A product obtained by polymerizing a vinyl ester compound with a chain transfer agent having a carboxyl group and then saponifying the polymerized product; and (4) a product obtained by reacting polyvinyl alcohol with a carboxylating agent; and the like.
Examples of the unsaturated monomer having a carboxyl group used in the methods (1) and (2) and the unsaturated monomer having a carboxylate group used in the method (2) include: ethylene-based unsaturated dicarboxylic acids such as maleic acid, fumaric acid, and itaconic acid; ethylene-based unsaturated dicarboxylic acid monoesters such as monoalkyl maleates, monoalkyl fumarates, and monoalkyl itaconates; ethylene-based unsaturated dicarboxylic acid diesters such as dialkyl maleates, dialkyl fumarates and dialkyl itaconates; ethylenically unsaturated carboxylic acid anhydrides such as maleic anhydride and itaconic anhydride; unsaturated monocarboxylic acids such as (meth) acrylic acid, and unsaturated monocarboxylic acid esters such as alkyl (meth) acrylates. In addition, as the unsaturated monomer having at least one selected from the group consisting of a carboxyl group and a carboxylate group, a salt of the above compound may also be used. These compounds may be used alone or in combination of two or more.
Examples of the vinyl ester compound used in the method (2) and the method (3) include vinyl acetate, vinyl formate, vinyl acrylate, vinyl versatate, and vinyl pivalate. Among these, vinyl acetate is preferable from the viewpoints of reactivity at the time of synthesis and easiness of starting. These compounds may be used alone or in combination of two or more.
Examples of the carboxylating agent used in the method (4) include: carboxylic acid anhydrides such as succinic anhydride, maleic anhydride, acetic anhydride, trimellitic anhydride, phthalic anhydride, pyromellitic anhydride, glutaric anhydride, hydrogenated phthalic anhydride, and naphthalene dicarboxylic anhydride. These may be used alone or in combination of two or more.
The amount of the anionic group (the proportion derived from the monomer having an anionic group) in the anionic polyvinyl alcohol is preferably 0.1 mol% or more, more preferably 0.5 mol% or more, and even more preferably 1 mol% or more from the viewpoint of further suppressing a sticky feeling and enhancing water retention and gel strength, and is preferably 10 mol% or less, more preferably 5 mol% or less, and even more preferably 3 mol% or less from the viewpoint of enhancing adhesiveness and enhancing the amount of water supplied and the moisturizing feeling when applied to the skin. As to the amount of anionic groups in the anionic polyvinyl alcohol, 1H-NMR (solvent: CDCl) can be used 3 ) The anionic polyvinyl alcohol before saponification was analyzed to determine.
From the viewpoint of further suppressing a sticky feeling and from the viewpoint of improving the water retention and gel strength, the saponification degree of the anionic polyvinyl alcohol is preferably 90 mol% or more, more preferably 95 mol% or more, and still more preferably 98 mol% or more. The upper limit of the saponification degree is not particularly limited, but is, for example, 100.0 mol% or less, preferably 99.9 mol% or less, and more preferably 99.5 mol% or less. The degree of saponification of anionic polyvinyl alcohol can be measured according to JIS K6726.
The polymerization degree of the anionic polyvinyl alcohol is preferably 100 or more, more preferably 500 or more, and more preferably 1000 or more from the viewpoint of suppressing a sticky feeling and improving water retention and gel strength, and is preferably 20 ten thousand or less, more preferably 1 ten thousand or less, and more preferably 4000 or less from the viewpoint of improving adhesion and improving flexibility and extensibility. The polymerization degree of anionic polyvinyl alcohol can be calculated from the relative viscosity of an aqueous solution of completely saponified polyvinyl alcohol and water (see JIS K6726.
Specific examples of the anionic polyvinyl alcohol include: KL-118, KL-318, KL-506, KM-118 and KM-618 manufactured by KURARAY; GOHSENX CKS50, GOHSENX T-330H, GOHSENX T-330, and GOHSENX T-350, all of which are available from Mitsubishi chemical corporation; JAPAN VAM & POVAL CO., AP-17, AT-17, AF-17 manufactured by LTD.
In the present invention, one or more of the components (A1) may be used alone or in combination.
From the viewpoint of obtaining an appropriate hardness, the viscosity (Brookfield viscometer S61 spindle, rotation speed of 20 rpm) of a 4% aqueous solution of the anionic polyvinyl alcohol of the component (A1) at 20 ℃ is preferably 10mPa · S or more, more preferably 20mPa · S or more, and still more preferably 25mPa · S or more; from the viewpoint of obtaining appropriate softness, the viscosity is preferably 50mPa · s or less, more preferably 40mPa · s or less, and further preferably 35mPa · s or less. Therefore, from the viewpoint of satisfying both appropriate hardness and softness, the viscosity is preferably 10 to 50mPa · s, more preferably 20 to 40mPa · s, and even more preferably 25 to 35mPa · s.
From the viewpoint of obtaining an appropriate hardness, the content of the component (A1) in the hydrogel of the present invention is 5% by mass or more, preferably 8% by mass or more and 20% by mass or less, preferably 12% by mass or less. From the above viewpoints, the content of the component (A1) in the hydrogel of the present invention is 5 mass% or more and 20 mass% or less, preferably 8 mass% or more and 12 mass% or less.
Component (A2)
The component (A2) is an acrylic copolymer obtained by polymerizing at least 1 monomer selected from acrylic acid, methacrylic acid, and alkyl (meth) acrylates having alkyl groups of 1 to 30 carbon atoms. The acrylic polymer as the component (A2) includes polyacrylic acid and sodium polyacrylate, crosslinked sodium polyacrylate, carbomer, acrylic resin.
Polyacrylic acid is a polymer formed by addition polymerization of acrylic acid monomers, and sodium polyacrylate is obtained by neutralizing polyacrylic acid with sodium hydroxide. As polyacrylic acid and sodium polyacrylate, the molecular weight is preferably 100 to 4000000, the viscosity is preferably 100 to 50000 mPas (0.5% by weight: 25 ℃ C., brookfield viscometer S61 to S64 spindle, the spindle and the rotation speed are selected differently depending on the viscosity of the measurement product), and commercially available products thereof include 323667, 181285, 306215, 306231, 306223, 447013, 420344, 81123 and the like of Merck corporation, nihon Junyaku AC-10H and Jurymer AC-1 0CreP, synthron Modarez V1300PX of Synthron corporation, oristar PAL of Orient Stars, C.I.T. TN 500, and the like. Carbomers are polyacrylic acid polymers, which are high molecular weight, crosslinked homopolymers. The viscosity is preferably 500 to 80000 mPas cps (0.2% aqueous,25 ℃, pH-neutral with KOH, brookfield viscometer S61 to S64 spindle, spindle and rotation speed are selected according to the viscosity of the measurement product), and commercially available products thereof include Ultrez 10, ultrez 21, ultrz 30 and the like, which are Luborun.
The acrylate copolymer is a polymer obtained by copolymerizing monomers such as methacrylate, acrylate, and acrylic acid in a certain ratio. In the present invention, both the methacrylic acid ester and the acrylic acid ester are alkyl (meth) acrylates having an alkyl group of 1 to 30 carbon atoms, and among them, methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, and C10-30 alkyl acrylate are preferable. The acrylate copolymer is preferably 100 to 80000 mPas (0.2% aqueous,25 ℃ C., pH adjusted to neutral with KOH, brookfield viscometer S61 to S64 spindle, spindle and rotation speed selected depending on the viscosity of the measurement product), and its commercially available products include Pemulen TR-1, pemulen TR-2, SF-1, SF-2, ETD 2020 available from Loborun, and ACULYN 88, ACULYN 22, ACULYN 28, and ACULYN 38 available from Rohm and Haas.
From the viewpoint of obtaining an appropriate hardness, the content of the component (A2) in the hydrogel of the present invention is 0.1 mass% or more and 20 mass% or less, preferably 15 mass% or less. From the above viewpoints, the content of the component (A2) in the hydrogel of the present invention is 0.1 mass% or more and 20 mass% or less, and preferably 0.1 mass% or more and 15 mass% or less.
Ingredient (A3)
The component (A3) is carboxymethyl cellulose (CMC), which is a cellulose ether compound obtained by carboxymethylation of cellulose.
From the viewpoint of obtaining an appropriate hardness, the viscosity of a 1% aqueous solution of the carboxymethyl cellulose as the component (A3) at 20 ℃ (Brookfield viscometer S61-S64 spindle, the spindle and the rotation speed are selected depending on the viscosity of the measurement product) is 200 mPas or more; from the viewpoint of obtaining appropriate softness, the viscosity is preferably 5000mPa · s or less. Therefore, the viscosity is preferably 200 to 5000mPa · s from the viewpoint of satisfying both appropriate hardness and softness.
As the carboxymethyl cellulose, commercially available products thereof include Aqualon, blanose, bondwell series of Himalayan, such as TH10A and 9H4 FU.
From the viewpoint of obtaining an appropriate hardness, the content of the component (A3) in the hydrogel of the present invention is 0.2 mass% or more and 20 mass% or less, preferably 15 mass% or less. From the above viewpoints, the content of the component (A3) in the hydrogel of the present invention is 0.2 mass% or more and 20 mass% or less, and preferably 0.5 mass% or more and 15 mass% or less.
In the present invention, the component (a) is 1 or 2 or more selected from the components (A1), (A2), and (A3), and preferably the component (a) is polyvinyl alcohol.
From the viewpoint of obtaining a gel having an appropriate viscosity, the total content of the component (a) in the hydrogel of the present invention is 0.1 mass% or more, preferably 0.5 mass% or more, and 30 mass% or less, preferably 20 mass% or less. From the above viewpoints, the total content of the component (a) in the hydrogel of the present invention is 0.1 mass% or more and 30 mass% or less, and preferably 0.5 mass% or more and 20 mass% or less.
[ component (B) ]
The component (B) used in the present invention is 1 or 2 or more selected from trivalent metal salts and borates.
As the trivalent metal salt of the component (B) used in the present invention, iron ions (Fe) can be contained 3+ ) Iron salt containing manganese ion (Mn) 3+ ) Manganese salt of (2), containing chromium ions (Cr) 3+ ) Chromium salt of (1) aluminum ion (Al) 3+ ) Among them, aluminum ion (Al) is preferred from the viewpoint of easy availability 3+ ) Of (2) an aluminum salt of (a).
Examples of the aluminum salt include 1 or 2 or more kinds of aluminum chloride, potassium alum, ammonium alum, aluminum acetate, aluminum magnesium methylsilicate, aluminum magnesium silicate, aluminum magnesium metasilicate, aluminum EDTA, aluminum allantoate, aluminum hydroxide, aluminum magnesium hydroxide, p-hydroxyaluminum aminoacetate, aluminum sulfate, aluminum potassium sulfate, aluminum lactate, aluminum glycollate, aluminum glycinate, aluminum oxide, and aluminum borate.
Among these, aluminum chloride, potassium alum, ammonium alum, aluminum acetate, aluminum magnesium methylsilicate, aluminum allantoate, aluminum sulfate, aluminum potassium sulfate, aluminum lactate, aluminum glycollate, and aluminum glycinate are preferable from the viewpoint of easy availability. More preferred are aluminum chloride, aluminum sulfate, potassium alum, and aluminum glycinate. Further preferred are aluminum chloride and aluminum sulfate.
When the trivalent metal salt is dissolved in water, trivalent metal ions are released; the irreversible gelation reaction occurs when an aqueous solution of the anionic polymer of component (a) is mixed with an aqueous solution of the trivalent metal salt of component (B). Wherein the trivalent metal ion in the trivalent metal salt reacts with the carboxylate radical in the component (A) to form covalent coordinate bond, thereby forming the reticular gel.
The borate as the component (B) used in the present invention mainly includes tetraborate (M [ B ] 4 O 5 (OH) 4 ]M is sodium, potassium or ammonium) and pentaborate (M [ B ] 5 O 6 (OH) 4 ]M is sodium, potassium or ammonium), sodium tetraborate is preferred from the viewpoint of availability. As a commercially available product, there may be mentionedAnd BORAX manufactured by Wako pure chemical industries, ltd.
When the borate is dissolved in water to form an aqueous borate solution, the borate anions present in the aqueous solution consist essentially of [ B (OH) 4 ] - 、[B 3 O 3 (OH) 4 ] - 、[B 4 O 5 (OH) 4 ] 2- 、[B 5 O 6 (OH) 4 ] - And the like.
When an aqueous solution of the anionic polymer of the component (A1) is mixed with an aqueous solution of the borate of the component (B), an irreversible gelation reaction occurs. Wherein the trivalent boron ion in the borate forms a covalent coordinate bond with the hydroxyl group in the component (A-1), thereby forming a network gel.
The hydrogel obtained by coordinate covalent bonding can have appropriate hardness and extensibility, and can maintain its shape even when attached to the skin for a long period of time.
The component (B) is dissolved in water and used as an aqueous solution. The component (B) may be used alone or in combination of 2 or more, and the content of the component (B) in the hydrogel of the present invention is 0.2 mass% or more and 3 mass% or less from the viewpoint of the extensibility of the hydrogel. From the above viewpoints, the content of the component (B) in the hydrogel of the present invention is 0.2 mass% or more and 3 mass% or less.
Therefore, from the viewpoint of ensuring the stability of the network structure of the hydrogel, the relationship between the component (B) and the component (a) is 0.5 to 10, preferably 3 to 6, in terms of the ratio of the molar amount of the trivalent metal ion contained in the component (B) to the molar amount of the carboxyl group contained in the component (a) ((molar amount of the trivalent metal ion in B/(molar amount of the carboxyl group in a)). This ratio is obtained by the following method. First, the trivalent metal ion in the component (B) is obtained by calculating the molar amount of the trivalent metal ion in the component B, and is denoted as M1. Next, the molar amount of the anionic groups in the component (A) was obtained by measuring the molar amount of the carboxylic acid groups in the component (A-1) and was designated as M2. The above molar ratio is obtained by dividing M1 by M2.
On the other hand, the mass ratio of the component (B) to the component (a) (the content of (B)/the content of (a)) is 0.001 to 0.5, preferably 0.01 to 0.06, from the viewpoint of ensuring the stability of the network structure of the hydrogel.
[ component (C) ]
The component (C) used in the present invention is a nonionic surfactant having an IOB value of 0.1 or more and 2 or less.
The nonionic surfactant with the IOB of less than 2 has the interfacial activity and shows hydrophilic and lipophilic amphipathy, and when the nonionic surfactant is added into a gel system, the skin feel shown by the oleophilic end is smooth and has strong skin affinity, so that the advantages of improving the sticky feel and the dry and astringent feel are achieved. When the IOB is more than 2, the nonionic surfactant has a decreased interfacial activity, a strong water-soluble ability, and a reduced smooth feeling exhibited by the oleophilic end, and is not effective for improving a dry and astringent feeling. When the IOB value is less than 0.1, the stability of the gel system is not favorable. The nonionic surfactant has an IOB value of 2.0 or less, preferably 1 to 1.5, and more preferably 1.16 to 1.37, from the viewpoint of achieving a non-sticky feeling and a non-dry and astringent feeling of the hydrogel. The nonionic surfactant has an IOB value of 0.1 or more from the viewpoint of stability of the gel system.
Specific examples of the nonionic surfactant as the component (C) include: PEG fatty acid ester, PEG hydrogenated castor oil, PEG fatty glyceride, PPG glucose polyether, PPG polyglycerol ether, polyglycerol fatty acid ester, PEG polydimethylsiloxane, sorbitan fatty acid ester, PEG sorbitan fatty acid ester, polysorbate, fatty alcohol polyether and glucoside. Among them, PEG fatty acid esters, PEG fatty acid glycerides, and the like are preferable.
Specific examples of the nonionic surfactant as the component (C) include: PPG-9 dipolylether (IOB value: 0.90), PPG-10 methylglucylether (IOB value: 0.95), PEG-7 glyceryl cocoate (IOB value: 1.16), PEG-6 caprylic/capric glyceride (IOB value: 1.25), PEG-60 castor oil (IOB value: 1.36), PEG-12 laurate (IOB value: 1.37), polyglyceryl-6 distearate (IOB value: 0.76), PEG-11 methyl ether polydimethylsiloxane (IOB value: 1.45), sorbitan laurate (IOB value: 0.86), PEG-6 sorbitan stearate (IOB value: 0.96), polysorbate-40 (IOB value: 1.56), laureth-9 (IOB value: 1.34), ceteareth-13 (IOB value: 1.42), decyl glucoside (IOB value: 1.57), and the like.
The component (C) may be used in 1 kind or a combination of 2 or more, and the content thereof is 2.0% by mass or more, preferably 3.0% by mass or more, and 10.0% by mass or less, preferably 5.0% by mass or less in the total composition from the viewpoint of non-dry and non-sticky feeling of the hydrogel. From the above viewpoints, the content of the component (C) in the hydrogel of the present invention is 2.0 mass% or more and 10.0 mass% or less, preferably 2.0 mass% or more and 5.0 mass% or less, and more preferably 2.0 mass% or more and 4.0 mass% or less.
From the viewpoint of improving both the sticky feeling and the dry feeling, the mass ratio of the component (C) to the content of the component (a) [ content of the component (C)/content of the component (a) ] is 0.15 to 2.0, preferably 0.15 to 0.5.
[ component (D) ]
The component (D) used in the present invention is water.
Examples of the water as the component (D) used in the present invention include water conventionally used in the cosmetic field such as deionized water, distilled water, high purity water, and ultrapure water.
In the present invention, the content of water as the component (D) in the hydrogel is 60 mass% or more, preferably 70 mass% or more, and 97 mass% or less, preferably 95 mass% or less, from the viewpoint of keeping the form of the hydrogel well and from the viewpoint of improving the dry, astringent and sticky feeling of the hydrogel well. From the above viewpoints, the content of water as the component (D) in the hydrogel of the present invention is 60 mass% or more and 97 mass% or less, and preferably 70 mass% or more and 95 mass% or less.
In the hydrogel of the present invention, water may be added specifically, or may be water contained in another raw material (for example, water added to components (a) to (C)).
[ other ingredients ]
The hydrogel of the present invention may further contain a polyol having a molecular weight of 50 to 380.
From the viewpoint of having little influence on the hydrogel viscosity, alcohols having an alkyl group as the main chain are preferable, diols are more preferable, and diols having a structure in which hydroxyl groups are not adjacent to each other in the main chain are further preferable.
Examples of the polyol having a molecular weight of 50 to 380 include: 1,2-propanediol, 1,3-propanediol, glycerin, 1,3-butanediol, 1,4-butanediol, dipropylene glycol, trehalose, and the like. Of these, from the viewpoint of ensuring a suitable viscosity of the hydrogel with a small influence on the viscosity of the hydrogel, 1 or 2 or more of 1,3-propanediol, 1,3-butanediol, 1,4-butanediol, 1,2-propanediol, glycerol and trehalose are preferable, and 1 or 2 or more of 1,3-propanediol, 1,3-butanediol, and 1,4-butanediol are more preferable.
From the viewpoint of stability of the hydrogel, the content of the polyhydric alcohol is 0.1% by mass or more, preferably 2% by mass or more, more preferably 5% by mass or more, and 27% by mass or less, preferably 20% by mass or less, more preferably 16.5% by mass or less, further preferably 10% by mass or less, further preferably 8% by mass or less in the total composition.
In addition, in the hydrogel of the present invention, in addition to the above-mentioned components, components generally used in cosmetics, for example, a moisturizing agent, a whitening agent, a blood circulation-promoting agent, an anti-inflammatory agent, a bactericide, an ultraviolet absorber, a coloring agent, a preservative, an antioxidant, a perfume, a pH adjuster, a chelating agent, and the like may be used within a range not affecting the effects of the present invention.
< method for producing hydrogel >
The method for producing the hydrogel of the present invention includes a method in which the component (A), the component (C) and the component (D) are mixed together to form an aqueous solution, the component (B) is dissolved in the component (D) to form an aqueous solution, and then the aqueous solution of the component (B) is added to the aqueous solutions of the components (A) and (C), stirred and left to stand to obtain the hydrogel.
The hydrogel of the present invention preferably has a viscosity of 500 pas or more and 8000 pas or less at room temperature (25 ℃ C.).
The hydrogel of the present invention can be easily taken out and does not remain in a package even when filled in a tube-like or bag-like package which is easy to carry.
The hydrogel of the present invention is used by being attached to the skin, preferably to any part of the face, body, hands and feet other than the scalp. Can be stretched and extended freely when in use, has good fitting degree to the skin, brings good moisture retention to users, is not sticky and dry, and is easy to peel off from the skin after use.
< method of Using hydrogel >
In any case, the hydrogel of the present invention can be applied to the skin as an external preparation for skin, thereby achieving skin care. Specifically, in use, the hydrogel may be first stretched to a suitable size and then attached to the skin; alternatively, the hydrogel is first applied to the skin and then spread to a suitable size, and then left on the skin for a period of time, preferably 1 minute to 2 hours, more preferably 5 minutes to 1 hour, and is easily peeled off after use, thereby obtaining a good skin care effect. In addition, the hydrogel can be used in combination with massage, and the massage can be performed directly by hand or with a tool such as sponge.
Further, the present invention provides a method for moisturizing skin, wherein the hydrogel of the present invention is applied to skin to moisturize the skin.
Preferred embodiments of the present invention are further disclosed below with respect to the above-described embodiments.
<1> a hydrogel, wherein,
comprises the following components (A), (B), (C) and (D):
(A) An anionic polymer;
(B) Trivalent metal salts and/or borates;
(C) A nonionic surfactant having an IOB value of 0.1 to 2;
(D) And (3) water.
<2> the hydrogel according to the above <1>, wherein,
the component (A) is 1 or 2 or more selected from the following components (A1), (A2) and (A3),
(A1) Anionic polyvinyl alcohol;
(A2) An acrylic copolymer obtained by polymerizing at least 1 monomer selected from acrylic acid, methacrylic acid, and alkyl (meth) acrylates having an alkyl group of 1 to 30 carbon atoms;
(A3) Carboxymethyl cellulose.
<3> the hydrogel according to the above <2>, wherein,
the viscosity of a 4% aqueous solution of the anionic polyvinyl alcohol of the component (A1) at 20 ℃ is preferably 10 mPas or more, more preferably 20 mPas or more, further preferably 25 mPas or more, and is preferably 50 mPas or less, more preferably 40 mPas or less, further preferably 35 mPas or less; further, it is preferably 10 to 50 mPas, more preferably 20 to 40 mPas, and further preferably 25 to 35 mPas. .
<4> the hydrogel according to <2> or <3> above, wherein,
the content of the component (A1) in the hydrogel is 5% by mass or more and 20% by mass or less, preferably 12% by mass or less; further, the content of the component (A1) in the hydrogel is 5 mass% or more and 20 mass% or less, preferably 8 mass% or more and 12 mass% or less.
<5> the hydrogel according to any one of above <2> to <4>, wherein,
the component (A2) is selected from 1 or more than 2 of polyacrylic acid and sodium polyacrylate, carbomer, methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, and C10-30 alkyl acrylate.
<6> the hydrogel according to any one of above <2> to <5>, wherein,
the content of the component (A2) in the hydrogel is 0.1 mass% or more and 20 mass% or less, preferably 15 mass% or less; further, the content of the component (A2) in the hydrogel is 0.1 mass% or more and 20 mass% or less, preferably 0.1 mass% or more and 15 mass% or less.
<7> the hydrogel according to any one of the above <2> to <6>, wherein,
the carboxymethyl cellulose as the component (A3) has a viscosity of 200 mPas or more, preferably 5000 mPas or less, and more preferably 200 to 5000 mPas in a 1% aqueous solution at 20 ℃.
<8> the hydrogel according to any one of above <2> to <7>, wherein,
the content of the component (A3) in the hydrogel is 0.2 mass% or more and 20 mass% or less, preferably 15 mass% or less; further, the content of the component (A3) in the hydrogel is 0.2 mass% or more and 20 mass% or less, and preferably 0.5 mass% or more and 15 mass% or less.
<9> the hydrogel according to any one of above <1> to <8>, wherein,
the total content of the component (a) in the hydrogel is 0.1% by mass or more, preferably 0.5% by mass or more, and 30% by mass or less, preferably 20% by mass or less; further, the total content of the component (a) is 0.1 mass% or more and 30 mass% or less, and preferably 0.5 mass% or more and 20 mass% or less.
<10> the hydrogel according to any one of the above <1> to <9>, wherein,
component (B) is selected from the group consisting of iron (Fe) ions 3+ ) Iron salt containing manganese ion (Mn) 3+ ) Manganese salt of (2), containing chromium ions (Cr) 3+ ) Chromium salt of (1) aluminum ion (Al) 3+ ) 1 or 2 or more of the aluminum salts of (a);
component (B) is preferably selected from aluminium salts and/or borate salts,
the component (B) is more preferably 1 or 2 or more selected from the group consisting of aluminum chloride, potassium alum, ammonium alum, aluminum acetate, magnesium aluminum methylsilicate, magnesium aluminum silicate, magnesium aluminum metasilicate, aluminum EDTA, allantoin, aluminum hydroxide, magnesium aluminum hydroxide, p-hydroxyaluminum aminoacetic acid, aluminum sulfate, potassium aluminum sulfate, aluminum lactate, dihydroxyaluminum glycinate, aluminum oxide, aluminum borate, sodium tetraborate, potassium tetraborate, ammonium tetraborate, sodium pentaborate, potassium pentaborate, and ammonium pentaborate.
<11> the hydrogel according to any one of above <1> to <10>, wherein,
the content of the component (B) in the hydrogel is 0.2 mass% or more and 3 mass% or less in terms of the amount of sodium borate; the content of the component (B) in the hydrogel is 0.2 mass% or more and 3 mass% or less in terms of the amount of sodium borate.
<12> the hydrogel according to any one of above <1> to <11>, wherein,
the ratio of the molar amount of trivalent metal ions in component (B) to the molar amount of anionic groups in component (A) is from 0.5 to 10, preferably from 3 to 6; (B) The mass ratio of (A) to (B) is 0.001 to 0.5, preferably 0.01 to 0.06.
<13> the hydrogel according to any one of above <1> to <12>, wherein,
the nonionic surfactant having an IOB value of 0.1 or more and 2 or less as component (C) is preferably 1 or 2 or more selected from the group consisting of PEG fatty acid esters, PEG hydrogenated castor oil, PEG fatty acid glycerides, PPG glucose polyether, PPG polyglyceryl ether, polyglyceryl fatty acid esters, PEG polydimethylsiloxane, sorbitan fatty acid esters, PEG sorbitan fatty acid esters, fatty alcohol polyethers, and glucosides.
<14> the hydrogel according to any one of above <1> to <13>, wherein,
the nonionic surfactant as the component (C) preferably has an IOB value of 1 to 1.5, more preferably 1.16 to 1.37.
<15> the hydrogel according to any one of above <1> to <14>, wherein,
the content of the component (C) in the hydrogel is 2.0% by mass or more, preferably 3.0% by mass or more, and 10.0% by mass or less, preferably 5.0% by mass or less; further, the content of the component (C) in the hydrogel is 2.0 mass% or more and 10.0 mass% or less, preferably 2.0 mass% or more and 5.0 mass% or less, and more preferably 2.0 mass% or more and 4.0 mass% or less.
<16> the hydrogel according to any one of the above <1> to <15>, wherein,
the mass ratio (C)/(A) of the component (C) to the component (A) is 0.15 to 2.0, preferably 0.15 to 0.5.
<17> the hydrogel according to any one of above <1> to <16>, wherein,
the content of water as the component (D) in the hydrogel is 60 mass% or more, preferably 70 mass% or more, and 97 mass% or less, preferably 95 mass% or less; the content of water as the component (D) in the hydrogel is 60 mass% or more and 97 mass% or less, and preferably 70 mass% or more and 95 mass% or less.
<18> the hydrogel according to any one of above <1> to <17>, wherein,
the hydrogel preferably has a viscosity of 500 pas or more and 8000 pas or less at room temperature (25 ℃).
<19> the use of the hydrogel according to any one of <1> to <18> above as an external preparation for skin.
<20> a skin care method, wherein the hydrogel according to any one of <1> to <18> is applied to the skin to care the skin.
<21> a method for moisturizing skin, wherein the hydrogel of any one of <1> to <18> is applied to the skin to moisturize the skin.
Examples
The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to the following examples. The amount of each component is mass%.
1. Manufacturing method
According to the compositions shown in tables 1 to 3 (the numerical values shown in table 1 are the contents of the effective components), the components (a), (C) and optionally other components than (a) were dispersed in deionized water at room temperature, and stirred in a water bath at 80 ℃ or higher to dissolve them completely, and after cooling to room temperature, the evaporated water content was made up, and then an aqueous solution of the component (B) was added, and the resulting mixture was stirred manually to cause gelation reaction between the component (a) and the component (B), and after standing, the mixture was stirred once again to obtain a hydrogel.
2. Evaluation of feeling of use
(1) Evaluation of Dry feeling-improving Effect
A sensory evaluation method was used. The samples of the control group to which no nonionic surfactant was added and the comparative samples to which the nonionic surfactant was added in the examples and comparative examples of the present invention were taken at 2g each, and the samples were rubbed with fingers to be subjected to the difference. The difference in dry and astringent feeling was evaluated according to the following scoring criteria. The test subjects 10 were evaluated for dryness and astringency for each of the control samples and the samples of the examples and comparative examples of the present invention, and scored. Finally, the 10-person scores were averaged.
And 3, dividing: the comparative samples were improved compared to the control group.
And 2, dividing: the comparative samples were slightly improved compared to the control group.
1 minute: the control sample showed no improvement compared to the control group.
(2) Evaluation of the effect of improving sticky feeling
A sensory evaluation method was used. The samples of the control group to which no nonionic surfactant was added and the comparative samples to which the nonionic surfactant was added in the examples and comparative examples of the present invention were taken at 2g each, and the difference between the samples was sensed by pressing with a finger. The difference in the sticky feeling was evaluated according to the following scoring criteria. The subjects were 10 persons, and each of the control group samples and the samples in the examples and comparative examples of the present invention was evaluated for the sticky feeling and scored. Finally, the 10-person scores were averaged.
And 3, dividing: the comparative samples were improved compared to the control group.
And 2, dividing: the comparative samples were slightly improved compared to the control group.
1 minute: the control sample showed no improvement compared to the control group.
TABLE 3
* Wherein B/A is Al 3+ Molar ratio of carboxyl groups.
As is clear from tables 1 to 3, the hydrogel of the present invention has excellent non-sticky feeling and non-dry feeling, and can realize good touch and use feeling.
The components in tables 1 to 3 are as follows.
Polyvinyl alcohol: GOHSENX T-330H (active ingredient content: 96%), manufactured by Mitsubishi Chemical Corporation.
Aluminum chloride: manufactured by the national drug group chemical agents limited.
Aluminum sulfate: manufactured by the national drug group chemical agents limited.
Aluminum glycinate: manufactured by the national drug group chemical agents limited.
Borax: manufactured by Jianrong pharmaceutical Co.
PPG-9 polyglyceryl ether: SY-DP9 (active ingredient content: 100%), manufactured by Sakamoto Yakuhin Kogyo Co., ltd.
PPG-10 methyl dextran ether: under the trade name MACBIO BRIDE MG-10P (active ingredient content: 100%), manufactured by NOF CORPORATION.
PEG-7 Glycerol cocoate: the product is CETIOL HE (active ingredient content: 100%), manufactured by BASF SE.
PEG-6 caprylic/capric glycerides: the trade name is TEGOSOFT GMC 6 (active ingredient content: 100%), manufactured by Evonik Operations GmbH.
PEG-60 Castor oil: the product is NIKKOL HCO-60 (active ingredient content: 100%), manufactured by Nippon surface Industries Co., ltd.
PEG-12 laurate: trade name of EMANON 1112 (active ingredient content: 100%), manufactured by Kao Corporation.
Methyl glucitol polyether-20: under the trade name MACBIO BRIDE MG-20E (active ingredient content: 100%), manufactured by NOF CORPORATION.
Methyl glucitol polyether-10: under the trade name MACBIO BRIDE MG-10E (active ingredient content: 100%), manufactured by NOF CORPORATION.
PROPYLENE GLYCOL (JSQI): propylene glycol, trade name (active ingredient content: 100%), manufactured by AGC inc.
1,3-butyl GLYCOL-P:1,3-butanediol, trade name (active ingredient content: 100%), manufactured by KH NeoChem co.
MEKKINS-M (UENO METHYL PARABEN NF): methylparaben, trade name (active ingredient content: 100%), manufactured by Ueno Fine Chemicals Industry, ltd.
The following examples of the formulation of the hydrogel of the present invention are given. It should be noted that the present invention is not limited to these formulation examples. The hydrogels of the formulation examples had no sticky and dry feeling and exhibited good touch and use feeling.
Formulation example 1:
polyvinyl alcohol (T330H) 11.2% by mass
Aluminum glycinate 0.345% by mass
PEG-6 caprylic/capric glycerides 0.33% by mass
PEG-12 laurate 1.67% by mass.
Formulation example 2:
polyvinyl alcohol (T330H) 11% by mass
10% by mass of borax
PEG-6 caprylic/capric glycerides 0.33% by mass
PEG-12 laurate 1.67% by mass.
Claims (11)
1. A hydrogel, wherein the hydrogel is a hydrogel,
comprises the following components (A), (B), (C) and (D):
(A) An anionic polymer;
(B) Trivalent metal salts and/or borates;
(C) A nonionic surfactant having an IOB value of 0.1 or more and 2 or less;
(D) And (3) water.
2. The hydrogel of claim 1, wherein,
the component (A) is 1 or 2 or more selected from the following components (A1), (A2) and (A3),
(A1) Anionic polyvinyl alcohol;
(A2) An acrylic copolymer obtained by polymerizing at least 1 monomer selected from acrylic acid, methacrylic acid, and alkyl (meth) acrylates having an alkyl group of 1 to 30 carbon atoms;
(A3) Carboxymethyl cellulose.
3. The hydrogel according to claim 1 or 2, wherein,
the component (B) is selected from aluminum salt and/or borate.
4. The hydrogel according to any one of claims 1 to 3,
the component (C) is 1 or more than 2 nonionic surfactants selected from PEG fatty acid ester, PEG hydrogenated castor oil, PEG fatty glyceride, PPG glucose polyether, PPG polyglycerol ether, polyglycerol fatty acid ester, PEG polydimethylsiloxane, sorbitan fatty acid ester, PEG sorbitan fatty acid ester, fatty alcohol polyether and glucoside.
5. The hydrogel according to any one of claims 1 to 4,
the mass ratio (C)/(A) of the component (C) to the component (A) is 0.15 to 2.
6. The hydrogel according to any one of claims 1 to 5,
the content of the component (A) in the hydrogel is 5 to 20% by mass.
7. The hydrogel according to any one of claims 1 to 6,
the content of the component (B) in the hydrogel is 0.2 to 3% by mass.
8. The hydrogel according to any one of claims 1 to 7, wherein,
the content of the component (C) in the hydrogel is 2 to 10% by mass.
9. The hydrogel according to any one of claims 1 to 8,
the content of the component (D) in the hydrogel is 60 to 93% by mass.
10. Use of the hydrogel according to any one of claims 1 to 9 as an external preparation for skin.
11. A method of skin care, wherein,
applying the hydrogel of any one of claims 1 to 9 to the skin.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW111119376A TW202312973A (en) | 2021-06-04 | 2022-05-25 | Hydrogel |
| JP2023572793A JP2024520007A (en) | 2021-06-04 | 2022-05-25 | Hydrogels |
| PCT/IB2022/054880 WO2022254289A1 (en) | 2021-06-04 | 2022-05-25 | Hydrogel |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2021106250778 | 2021-06-04 | ||
| CN202110625077 | 2021-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115429715A true CN115429715A (en) | 2022-12-06 |
Family
ID=84241505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210402526.7A Pending CN115429715A (en) | 2021-06-04 | 2022-04-18 | Hydrogels |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2024520007A (en) |
| CN (1) | CN115429715A (en) |
| TW (1) | TW202312973A (en) |
| WO (1) | WO2022254289A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024178530A1 (en) * | 2023-02-27 | 2024-09-06 | L'oreal | Composition for caring for keratin materials in the form of hydrogel |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3736761B2 (en) * | 2002-09-20 | 2006-01-18 | 花王株式会社 | Skin cosmetics |
| JP5856739B2 (en) * | 2011-02-15 | 2016-02-10 | 花王株式会社 | Body cosmetics for blood circulation promotion |
| JP6393610B2 (en) * | 2014-12-18 | 2018-09-19 | 花王株式会社 | Hydrogel preparation for neck |
| JP6594937B2 (en) * | 2016-09-05 | 2019-10-23 | 久光製薬株式会社 | Sheet-like pack and method for producing the same |
| JP6840324B2 (en) * | 2017-03-13 | 2021-03-10 | 日本メナード化粧品株式会社 | Topical skin for acne prevention and / or improvement |
-
2022
- 2022-04-18 CN CN202210402526.7A patent/CN115429715A/en active Pending
- 2022-05-25 JP JP2023572793A patent/JP2024520007A/en active Pending
- 2022-05-25 TW TW111119376A patent/TW202312973A/en unknown
- 2022-05-25 WO PCT/IB2022/054880 patent/WO2022254289A1/en active Application Filing
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024178530A1 (en) * | 2023-02-27 | 2024-09-06 | L'oreal | Composition for caring for keratin materials in the form of hydrogel |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022254289A1 (en) | 2022-12-08 |
| TW202312973A (en) | 2023-04-01 |
| JP2024520007A (en) | 2024-05-21 |
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