CN107281062A - A kind of whitening and anti-acne gel mask and preparation method thereof - Google Patents
A kind of whitening and anti-acne gel mask and preparation method thereof Download PDFInfo
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- CN107281062A CN107281062A CN201710490179.7A CN201710490179A CN107281062A CN 107281062 A CN107281062 A CN 107281062A CN 201710490179 A CN201710490179 A CN 201710490179A CN 107281062 A CN107281062 A CN 107281062A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/066—Multiple emulsions, e.g. water-in-oil-in-water
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
Abstract
The present invention relates to cosmetic products field, there is provided a kind of whitening and anti-acne gel mask and preparation method thereof.The facial mask includes the component of following parts by weight：40 60 parts of aloe extract, 46 parts of water soluble chitosan, 48 parts of hyaluronic acid, 48 parts of whitening and anti-acne microemulsion, 15 parts of antiseptic, 15 parts of coalescents, 13 parts of silk gum, 1 10 parts of pH adjusting agent, 15 25 parts of water.The facial mask of the present invention is spread on after face, and its active ingredient contained can be absorbed rapidly by skin of face, plays whitening, anti-acne effect.In addition, the facial mask of the present invention also has outstanding antibacterial action, long acne position is prevented to be infected by bacterial, while the antiseptic will not cause excessive damage to cell.
Description
Technical field
The present invention relates to cosmetic products field, especially, it is related to a kind of whitening and anti-acne gel mask and preparation method thereof.
Background technology
Gel mask is that, using hydrophilic gel as mask matrix, inside is rich in the nutritional ingredient and water needed for a large amount of skins
Point, stronger applicating property is non-stimulated to skin.The facial mask of various functions is sold on the market at present, wherein on whitening, anti-acne work(
The facial mask of effect also has many.
Such as patent CN201610475806.5 discloses a kind of anti-acne anti-inflammatory facial mask, by the raw material system of following mass fraction
Into：8-13 parts of aloe extract, 10-15 parts of tea tree ethereal oil, 6-8 parts of Honegsukle flower P.E, 7-8 parts of chrysanthemum extract, witch hazel
2-4 parts of extract, 5-9 parts of hyaluronic acid, 6-8 parts of cherry extract, 7-12 parts of red pomegranate essential oil, 2-4 parts of shaddock essential oil, cucumber
12-16 parts of juice, 5-7 parts of lemon juice, 3-7 parts of sodium hyaluronate, 12-14 parts of marine algae extract, 20-26 parts of distilled water.Anti-acne of the present invention
Except acne, anti-inflammation detumescence sterilizes antibacterial, while can desalinate the acne scar acne print of small pox generation again, improves blee.
The advantage of the invention is that, containing the natural plant composition with anti-acne and antibacterial, security, mildness are good, one
Anti-acne and antibacterial action can be played by determining degree.But it has the disadvantage：1st, natural component, absorbability of the skin to it are directly used
It is not ideal enough.2nd, the antibacterial activity of natural antibacterial ingredient is poor compared to chemical antiseptic.But if directly add chemical antibacterial
Agent has certain side effect to Skin Cell again.Therefore the face that a kind of skin absorption is good, safe, antibiotic property is strong is obtained
Film is highly desirable to.
The content of the invention
In order to solve the above-mentioned technical problem, the invention provides a kind of whitening and anti-acne gel mask and preparation method thereof.This
The facial mask of invention is spread on after face, and its active ingredient contained can be absorbed rapidly by skin of face, is played whitening, anti-acne and is made
With.In addition, the facial mask of the present invention also has outstanding antibacterial action, long acne position is prevented to be infected by bacterial, while the antiseptic
Excessive damage will not be caused to cell.
To achieve the above object, the invention provides a kind of whitening and anti-acne gel mask, the component of following parts by weight is included：
40-60 parts of aloe extract,
4-6 parts of water soluble chitosan,
4-8 parts of hyaluronic acid,
4-8 parts of whitening and anti-acne microemulsion,
1-5 parts of antiseptic,
1-5 parts of coalescents,
1-3 parts of silk gum,
1-10 parts of pH adjusting agent,
15-25 parts of water.
In the formula of the present invention, it is in mucus shape after aloe extract water suction, easily coats and in skin surface film forming,
Moisturizing, good permeability, using it as main base, biological safety is good, small to skin irritatin.
Water soluble chitosan, which is dissolved in after water, forms cotton-shaped with certain stickiness, with cladding effective active matter and guarantor
Wet effect, silk gum is natural materials, primarily serves raising facial mask in the effect of skin adhesive power.The whitening that the present invention contains resists
Acne microemulsion, compared to traditional natural extract with similar whitening, anti-acne function, its advantage is being capable of rapid cellular suction
Receive, so that effect is more preferable.There is antiseptic in inventive formulation simultaneously, long acne position bacterium infection can be prevented.
Preferably, the whitening and anti-acne microemulsion is to include fibroin albumen, Angelica Dahurica extract and salicylic water bag
Water-in-oil microemulsion agent.
Angelica Dahurica extract can play anti-acne, antiinflammation, and fibroin albumen richness can resist ultraviolet, play whitening effect
Really.Salicylic acid has effects that anti-inflammatory, detumescence, can coordinate Angelica Dahurica extract one is logical to play anti-acne effect.
Preferably, the preparation method of the whitening and anti-acne microemulsion is：By fibroin albumen, Angelica Dahurica extract and salicylic acid
It is dissolved in the water, adds after surfactant stirs and aqueous phase solution is made；By aqueous phase solution be added to containing fibroin albumen,
In the tea oil of Angelica Dahurica extract, salicylic acid and surfactant, Water-In-Oil particle is made after being sufficiently stirred for；Finally by Water-In-Oil
Particle is added in the water containing fibroin albumen, Angelica Dahurica extract, salicylic acid and surfactant, separates and is made after being sufficiently stirred for
The whitening and anti-acne microemulsion of W/O/W.
Whitening and anti-acne microemulsion made from the above method, it is and each with aqueous phase-oil phase and-three layers of clad structure of aqueous phase
Contain active material (fibroin albumen, Angelica Dahurica extract and salicylic acid) in layer water/oil phase, it has the benefit that, skin is thin
It is a variety of in born of the same parents that there is hydroaropic substance (cell liquid, cytoplasm etc.) and lipophilicity substance (cell membrane etc.), it is beautiful after facial mask is smeared
White anti-acne microemulsion can successively penetrate into cell, when meeting water hydroaropic substance, its aqueous layer material be dissolved in wherein, from
And discharge active material；When running into lipophilicity substance, its oil phase layer material is dissolved in wherein, also discharges active material.Therefore its
It fully rapid osmotic can enter cell, promote to absorb and work.In addition oil phase substance of the invention selects tea oil, tea oil
Itself also has good anti-oxidant, antibacterial action.
Preferably, the surfactant is polysorbas20, polysorbate40, polysorbate60 or Tween 80.
Preferably, the antiseptic is polycaprolactone, itaconic acid and methacrylic acid -2- (the diformazan ammonia of end group hydroxyl
Base) ethyl ester triblock copolymer.
Preferably, the polycaprolactone of the end group hydroxyl, itaconic acid and methacrylic acid -2- (dimethylamino) ethyl ester
The preparation method of triblock copolymer is：
The polycaprolactone of 8-10 parts by weight end group hydroxyls is dissolved in chloroform, to it under the conditions of nitrogen atmosphere, 0-5 DEG C
It is added dropwise after the bromo isobutyl acylbromide of 0.2-0.4 parts by weight, reaction 16-20h, reaction product is added in absolute methanol and sunk
Form sediment, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), 0.2-0.4 parts by weight cuprous bromides are added,
8-12 parts by weight itaconic acids are added under nitrogen atmosphere, and then the polymerisation 8-12h at 75-85 DEG C adds 10-15 parts by weight
Methacrylic acid -2- (dimethylamino) ethyl ester, is incubated polymerisation 4-6h, reaction product is precipitated, filtered, three are obtained embedding
Section copolymer.
In general, after skin is infected by bacterial, infected cell can secret out of the acidic materials such as lactic acid, so that
It is in faintly acid to obtain the infected place of wound.When skin is not infected or after infected place's healing, it returns to original in being in again
Property.According to this characteristic, above-mentioned antiseptic has been made in the present inventor.The antiseptic by three kinds of monomers (end group hydroxyl gather oneself
Lactone, itaconic acid and methacrylic acid -2- (dimethylamino) ethyl ester) copolymerization obtains, wherein, methacrylic acid -2- (diformazan ammonia
Base) ethyl ester due to quaternary ammonium salt functional group have antibiotic property.Above-mentioned copolymer has following characteristic：In weak acid environment
Under, segment where itaconic acid is in electroneutral, the polycaprolactone and methacrylic acid -2- (dimethylamino) ethyl ester at its two ends) segment
Trail, copolymer is in integrally positive electricity, and now, copolymer has antibiotic property.In neutral environment, the intermediate chain where itaconic acid
Section is in negative electricity, and the polycaprolactone at its two ends and methacrylic acid -2- (dimethylamino) ethyl ester) segment is in positive electricity, in electrostatic work
Under, antibiotic property is greatly reduced.Compared with other accompany antiseptic, antiseptic of the invention infected only in wound is in weak acid
Property after can just show preferable antibiotic property, for be not infected or remove metainfective skin, without antibiotic property.Because
Antiseptic can also be damaged while antibacterial to human body cell, and the antiseptic of the present invention can be rapid after bacterial destruction
Do not occur antibacterial action, excessively injury will not be caused to human body cell.
Preferably, the antiseptic is nano-scale particle.
Preferably, the coalescents are polyvinyl alcohol or xanthans.
Present invention also offers a kind of preparation method of whitening and anti-acne gel mask, comprise the following steps：
1) whitening and anti-acne microemulsion is prepared.
2) by proportioning respectively by aloe extract, water soluble chitosan, hyaluronic acid, whitening and anti-acne microemulsion, antiseptic,
Coalescents, silk gum are added in water, are stirred, are obtained sticky gelatinous mixture.
3) pH adjusting agent is added, the pH value of the gelatinous mixture is adjusted into 7-8, i.e. finished product.
The invention has the advantages that：The facial mask of the present invention is spread on after face, and its active ingredient contained can be fast
Speed is absorbed by skin of face, plays whitening, anti-acne effect, and good permeability after coating, and user's comfort level is high.In addition, this hair
Bright facial mask also has outstanding antibacterial action, prevents long acne position to be infected by bacterial, while the antiseptic will not be made to cell
Into excessive damage.
Embodiment
Embodiments of the invention are described in detail below, but the present invention can be limited and covered according to claim
Multitude of different ways implement.
Embodiment 1
A kind of whitening and anti-acne gel mask, includes the component of following parts by weight：
50 parts of aloe extract,
5 parts of water soluble chitosan,
6 parts of hyaluronic acid,
6 parts of whitening and anti-acne microemulsion,
3 parts of antiseptic,
3 parts of coalescents,
2 parts of silk gum,
Appropriate pH adjusting agent,
20 parts of water.
Wherein, the whitening and anti-acne microemulsion is to include fibroin albumen, Angelica Dahurica extract and salicylic oil-in-water bag
Water microemulsion, its preparation method is：Fibroin albumen, Angelica Dahurica extract and salicylic acid are dissolved in the water, surfactant is added
Aqueous phase solution is made after stirring in (polysorbas20)；Aqueous phase solution is added to containing fibroin albumen, Angelica Dahurica extract and bigcatkin willow
In the tea oil of acid and surfactant (polysorbas20), Water-In-Oil particle is made after being sufficiently stirred for；Finally Water-In-Oil particle is added
It is added in the water containing fibroin albumen, Angelica Dahurica extract and salicylic acid and surfactant (polysorbas20), is separated after being sufficiently stirred for
The whitening and anti-acne microemulsion of W/O/W is made.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 9 parts by weight end group hydroxyls is dissolved in chloroform
In, it is added dropwise under the conditions of nitrogen atmosphere, 2 DEG C to it after bromo isobutyl acylbromide of 0.3 parts by weight, reaction 18h, reaction product is added
Add in absolute methanol and precipitated, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.3 parts by weight cuprous bromide, adds 10 parts by weight itaconic acids, polymerisation 10h, is then added at 80 DEG C under nitrogen atmosphere
12 weight parts of methacrylic acid -2- (dimethylamino) ethyl esters, are incubated polymerisation 5h, reaction product are precipitated, filtered, is obtained
To triblock copolymer.
The preparation method of above-mentioned whitening and anti-acne gel mask, comprises the following steps：
1) whitening and anti-acne microemulsion is prepared.
2) by proportioning respectively by aloe extract, water soluble chitosan, hyaluronic acid, whitening and anti-acne microemulsion, antiseptic,
Coalescents, silk gum are added in water, are stirred, are obtained sticky gelatinous mixture.
3) pH adjusting agent is added, the pH value of the gelatinous mixture is adjusted into 8, i.e. finished product.
Embodiment 2
A kind of whitening and anti-acne gel mask, includes the component of following parts by weight：
40 parts of aloe extract,
4 parts of water soluble chitosan,
4 parts of hyaluronic acid,
4 parts of whitening and anti-acne microemulsion,
1 part of antiseptic,
1 part of coalescents,
1 part of silk gum,
Appropriate pH adjusting agent,
15 parts of water.
Wherein, the whitening and anti-acne microemulsion is to include fibroin albumen, Angelica Dahurica extract and salicylic oil-in-water bag
Water microemulsion, its preparation method is：Fibroin albumen, Angelica Dahurica extract and salicylic acid are dissolved in the water, surfactant is added
Aqueous phase solution is made after stirring in (polysorbate40)；Aqueous phase solution is added to containing fibroin albumen, Angelica Dahurica extract and bigcatkin willow
In the tea oil of acid and surfactant (polysorbate40), Water-In-Oil particle is made after being sufficiently stirred for；Finally Water-In-Oil particle is added
It is added in the water containing fibroin albumen, Angelica Dahurica extract and salicylic acid and surfactant (polysorbate40), is separated after being sufficiently stirred for
The whitening and anti-acne microemulsion of W/O/W is made.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 8 parts by weight end group hydroxyls is dissolved in chloroform
In, it is added dropwise under the conditions of nitrogen atmosphere, 0 DEG C to it after bromo isobutyl acylbromide of 0.2 parts by weight, reaction 16h, reaction product is added
Add in absolute methanol and precipitated, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.2 parts by weight cuprous bromide, adds 8 parts by weight itaconic acids, polymerisation 12h, is then added at 75 DEG C under nitrogen atmosphere
10 weight parts of methacrylic acid -2- (dimethylamino) ethyl esters, are incubated polymerisation 6h, reaction product are precipitated, filtered, is obtained
To triblock copolymer.
The preparation method of above-mentioned whitening and anti-acne gel mask, comprises the following steps：
1) whitening and anti-acne microemulsion is prepared.
2) by proportioning respectively by aloe extract, water soluble chitosan, hyaluronic acid, whitening and anti-acne microemulsion, antiseptic,
Coalescents, silk gum are added in water, are stirred, are obtained sticky gelatinous mixture.
3) pH adjusting agent is added, the pH value of the gelatinous mixture is adjusted into 7.5, i.e. finished product.
Embodiment 3
A kind of whitening and anti-acne gel mask, includes the component of following parts by weight：
60 parts of aloe extract,
6 parts of water soluble chitosan,
8 parts of hyaluronic acid,
8 parts of whitening and anti-acne microemulsion,
5 parts of antiseptic,
5 parts of coalescents,
3 parts of silk gum,
Appropriate pH adjusting agent,
25 parts of water.
Wherein, the whitening and anti-acne microemulsion is to include fibroin albumen, Angelica Dahurica extract and salicylic oil-in-water bag
Water microemulsion, its preparation method is：Fibroin albumen, Angelica Dahurica extract and salicylic acid are dissolved in the water, surfactant is added
Aqueous phase solution is made after stirring in (polysorbate60)；Aqueous phase solution is added to containing fibroin albumen, Angelica Dahurica extract and bigcatkin willow
In the tea oil of acid and surfactant (polysorbate60), Water-In-Oil particle is made after being sufficiently stirred for；Finally Water-In-Oil particle is added
It is added in the water containing fibroin albumen, Angelica Dahurica extract and salicylic acid and surfactant (polysorbate60), is separated after being sufficiently stirred for
The whitening and anti-acne microemulsion of W/O/W is made.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 10 parts by weight end group hydroxyls is dissolved in chlorine
In imitative, it is added dropwise under the conditions of nitrogen atmosphere, 5 DEG C to it after bromo isobutyl acylbromide of 0.4 parts by weight, reaction 20h, by reaction product
Precipitated added in absolute methanol, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.4 parts by weight cuprous bromide, adds 12 parts by weight itaconic acids, polymerisation 8h, is then added at 85 DEG C under nitrogen atmosphere
15 weight parts of methacrylic acid -2- (dimethylamino) ethyl esters, are incubated polymerisation 6h, reaction product are precipitated, filtered, is obtained
To triblock copolymer.
The preparation method of above-mentioned whitening and anti-acne gel mask, comprises the following steps：
1) whitening and anti-acne microemulsion is prepared.
2) by proportioning respectively by aloe extract, water soluble chitosan, hyaluronic acid, whitening and anti-acne microemulsion, antiseptic,
Coalescents, silk gum are added in water, are stirred, are obtained sticky gelatinous mixture.
3) pH adjusting agent is added, the pH value of the gelatinous mixture is adjusted into 7, i.e. finished product.
Embodiment 4
A kind of whitening and anti-acne gel mask, includes the component of following parts by weight：
45 parts of aloe extract,
5 parts of water soluble chitosan,
5 parts of hyaluronic acid,
5 parts of whitening and anti-acne microemulsion,
2 parts of antiseptic,
2 parts of coalescents,
2 parts of silk gum,
Appropriate pH adjusting agent,
18 parts of water.
Wherein, the whitening and anti-acne microemulsion is to include fibroin albumen, Angelica Dahurica extract and salicylic oil-in-water bag
Water microemulsion, its preparation method is：Fibroin albumen, Angelica Dahurica extract and salicylic acid are dissolved in the water, surfactant is added
Aqueous phase solution is made after stirring in (Tween 80)；Aqueous phase solution is added to containing fibroin albumen, Angelica Dahurica extract and bigcatkin willow
In the tea oil of acid and surfactant (Tween 80), Water-In-Oil particle is made after being sufficiently stirred for；Finally Water-In-Oil particle is added
It is added in the water containing fibroin albumen, Angelica Dahurica extract and salicylic acid and surfactant (Tween 80), is separated after being sufficiently stirred for
The whitening and anti-acne microemulsion of W/O/W is made.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 8 parts by weight end group hydroxyls is dissolved in chloroform
In, it is added dropwise under the conditions of nitrogen atmosphere, 0 DEG C to it after bromo isobutyl acylbromide of 0.3 parts by weight, reaction 18h, reaction product is added
Add in absolute methanol and precipitated, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.3 parts by weight cuprous bromide, adds 8-12 parts by weight itaconic acids, polymerisation 9h, Ran Houjia at 80 DEG C under nitrogen atmosphere
Enter 14 weight parts of methacrylic acid -2- (dimethylamino) ethyl esters, be incubated polymerisation 5.5h, reaction product is precipitated, mistake
Filter, obtains triblock copolymer.
The preparation method of above-mentioned whitening and anti-acne gel mask, comprises the following steps：
1) whitening and anti-acne microemulsion is prepared.
2) by proportioning respectively by aloe extract, water soluble chitosan, hyaluronic acid, whitening and anti-acne microemulsion, antiseptic,
Coalescents, silk gum are added in water, are stirred, are obtained sticky gelatinous mixture.
3) pH adjusting agent is added, the pH value of the gelatinous mixture is adjusted into 7.4, i.e. finished product.
Embodiment 5
A kind of whitening and anti-acne gel mask, includes the component of following parts by weight：
55 parts of aloe extract,
6 parts of water soluble chitosan,
7 parts of hyaluronic acid,
7 parts of whitening and anti-acne microemulsion,
4 parts of antiseptic,
4 parts of coalescents,
3 parts of silk gum,
Appropriate pH adjusting agent,
22 parts of water.
Wherein, the whitening and anti-acne microemulsion is to include fibroin albumen, Angelica Dahurica extract and salicylic oil-in-water bag
Water microemulsion, its preparation method is：Fibroin albumen, Angelica Dahurica extract and salicylic acid are dissolved in the water, surfactant is added
Aqueous phase solution is made after stirring in (polysorbas20)；Aqueous phase solution is added to containing fibroin albumen, Angelica Dahurica extract and bigcatkin willow
In the tea oil of acid and surfactant (polysorbas20), Water-In-Oil particle is made after being sufficiently stirred for；Finally Water-In-Oil particle is added
It is added in the water containing fibroin albumen, Angelica Dahurica extract and salicylic acid and surfactant (polysorbas20), is separated after being sufficiently stirred for
The whitening and anti-acne microemulsion of W/O/W is made.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 8 parts by weight end group hydroxyls is dissolved in chloroform
In, it is added dropwise under the conditions of nitrogen atmosphere, 1 DEG C to it after bromo isobutyl acylbromide of 0.2 parts by weight, reaction 16h, reaction product is added
Add in absolute methanol and precipitated, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.2 parts by weight cuprous bromide, adds 8 parts by weight itaconic acids, polymerisation 9h, then adds 12 at 80 DEG C under nitrogen atmosphere
Weight parts of methacrylic acid -2- (dimethylamino) ethyl ester, is incubated polymerisation 4.5h, reaction product is precipitated, filtered, is obtained
To triblock copolymer.
The preparation method of above-mentioned whitening and anti-acne gel mask, comprises the following steps：
1) whitening and anti-acne microemulsion is prepared.
2) by proportioning respectively by aloe extract, water soluble chitosan, hyaluronic acid, whitening and anti-acne microemulsion, antiseptic,
Coalescents, silk gum are added in water, are stirred, are obtained sticky gelatinous mixture.
3) pH adjusting agent is added, the pH value of the gelatinous mixture is adjusted into 7.0, i.e. finished product.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (9)
1. a kind of whitening and anti-acne gel mask, it is characterised in that include the component of following parts by weight：
40-60 parts of aloe extract,
4-6 parts of water soluble chitosan,
4-8 parts of hyaluronic acid,
4-8 parts of whitening and anti-acne microemulsion,
1-5 parts of antiseptic,
1-5 parts of coalescents,
1-3 parts of silk gum,
1-10 parts of pH adjusting agent,
15-25 parts of water.
2. a kind of whitening and anti-acne gel mask according to claim 1, it is characterised in that the whitening and anti-acne microemulsion is
Include fibroin albumen, Angelica Dahurica extract and salicylic W/O/W microemulsion.
3. a kind of whitening and anti-acne gel mask according to claim 2, it is characterised in that the whitening and anti-acne microemulsion
Preparation method is：
Fibroin albumen, Angelica Dahurica extract and salicylic acid are dissolved in the water, adds after surfactant stirs and aqueous phase is made
Solution；Aqueous phase solution is added in the tea oil containing fibroin albumen, Angelica Dahurica extract, salicylic acid and surfactant, filled
Divide and Water-In-Oil particle is made after stirring；Finally by Water-In-Oil particle be added to containing fibroin albumen, Angelica Dahurica extract, salicylic acid and
In the water of surfactant, the whitening and anti-acne microemulsion that W/O/W is made is separated after being sufficiently stirred for.
4. a kind of whitening and anti-acne gel mask according to claim 3, it is characterised in that the surfactant is tween
20th, polysorbate40, polysorbate60 or Tween 80.
5. a kind of whitening and anti-acne gel mask according to claim 1, it is characterised in that the antiseptic is that end group contains hydroxyl
The triblock copolymer of the polycaprolactone of base, itaconic acid and methacrylic acid -2- (dimethylamino) ethyl ester.
6. a kind of whitening and anti-acne gel mask according to claim 5, it is characterised in that the end group hydroxyl gathers oneself
The preparation method of the triblock copolymer of lactone, itaconic acid and methacrylic acid -2- (dimethylamino) ethyl ester is：
The polycaprolactone of 8-10 parts by weight end group hydroxyls is dissolved in chloroform, is added dropwise under the conditions of nitrogen atmosphere, 0-5 DEG C to it
After the bromo isobutyl acylbromide of 0.2-0.4 parts by weight, reaction 16-20h, reaction product is added in absolute methanol and precipitated,
Obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), 0.2-0.4 parts by weight cuprous bromides are added,
8-12 parts by weight itaconic acids are added under nitrogen atmosphere, then the polymerisation 8-12h at 75-85 DEG C adds 10-15 parts by weight first
Base acrylic acid -2- (dimethylamino) ethyl ester, is incubated polymerisation 4-6h, reaction product is precipitated, filtered, three block is obtained
Copolymer.
7. a kind of whitening and anti-acne gel mask according to claim 5, it is characterised in that the antiseptic is nanoscale
Grain.
8. a kind of whitening and anti-acne gel mask according to claim 1, it is characterised in that the coalescents are polyethylene
Alcohol or xanthans.
9. a kind of a kind of preparation method of whitening and anti-acne gel mask according to one of claim 1-8, it is characterised in that
Comprise the following steps：
1) whitening and anti-acne microemulsion is prepared；
2) by proportioning respectively by aloe extract, water soluble chitosan, hyaluronic acid, whitening and anti-acne microemulsion, antiseptic, film forming
Auxiliary agent, silk gum are added in water, are stirred, are obtained sticky gelatinous mixture；
3) pH adjusting agent is added, the pH value of the gelatinous mixture is adjusted into 7-8, i.e. finished product.
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|---|---|---|---|
| CN201710490179.7A CN107281062A (en) | 2017-06-25 | 2017-06-25 | A kind of whitening and anti-acne gel mask and preparation method thereof |
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| CN201710490179.7A CN107281062A (en) | 2017-06-25 | 2017-06-25 | A kind of whitening and anti-acne gel mask and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478485A (en) * | 2018-05-04 | 2018-09-04 | 邵立坤 | A kind of temperature-sensitive hydrogel facial mask and preparation method thereof |
| CN111759750A (en) * | 2020-08-06 | 2020-10-13 | 苏州讯如电子科技有限公司 | Hydrogel sustained-release mask for removing acne and lightening spots and preparation method thereof |
| IT201900014607A1 (en) * | 2019-08-09 | 2021-02-09 | Sapienza Univ Di Roma | Nanofibroin and compositions containing it for cosmetic applications |
-
2017
- 2017-06-25 CN CN201710490179.7A patent/CN107281062A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108478485A (en) * | 2018-05-04 | 2018-09-04 | 邵立坤 | A kind of temperature-sensitive hydrogel facial mask and preparation method thereof |
| IT201900014607A1 (en) * | 2019-08-09 | 2021-02-09 | Sapienza Univ Di Roma | Nanofibroin and compositions containing it for cosmetic applications |
| CN111759750A (en) * | 2020-08-06 | 2020-10-13 | 苏州讯如电子科技有限公司 | Hydrogel sustained-release mask for removing acne and lightening spots and preparation method thereof |
| CN111759750B (en) * | 2020-08-06 | 2021-11-30 | 乐清市然景电气有限公司 | Hydrogel sustained-release mask for removing acne and lightening spots and preparation method thereof |
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