CN107281261A - A kind of mouth ulcer paster easily absorbed and preparation method thereof - Google Patents
A kind of mouth ulcer paster easily absorbed and preparation method thereof Download PDFInfo
- Publication number
- CN107281261A CN107281261A CN201710490178.2A CN201710490178A CN107281261A CN 107281261 A CN107281261 A CN 107281261A CN 201710490178 A CN201710490178 A CN 201710490178A CN 107281261 A CN107281261 A CN 107281261A
- Authority
- CN
- China
- Prior art keywords
- parts
- easily absorbed
- active component
- mouth ulcer
- micro emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028034 Mouth ulceration Diseases 0.000 title claims abstract description 33
- 208000007117 Oral Ulcer Diseases 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000003814 drug Substances 0.000 claims abstract description 56
- 239000004530 micro-emulsion Substances 0.000 claims abstract description 51
- 230000002421 anti-septic effect Effects 0.000 claims abstract description 26
- 239000011248 coating agent Substances 0.000 claims abstract description 18
- 239000000314 lubricant Substances 0.000 claims abstract description 18
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 17
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940116229 borneol Drugs 0.000 claims abstract description 17
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 17
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 17
- 241000241413 Propolis Species 0.000 claims abstract description 16
- 229940069949 propolis Drugs 0.000 claims abstract description 16
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 15
- 239000003002 pH adjusting agent Substances 0.000 claims abstract description 15
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 15
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 15
- 238000010521 absorption reaction Methods 0.000 claims abstract description 5
- 229920001610 polycaprolactone Polymers 0.000 claims description 33
- 239000004632 polycaprolactone Substances 0.000 claims description 33
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 28
- 239000004094 surface-active agent Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 19
- 239000002245 particle Substances 0.000 claims description 19
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims description 18
- 239000003921 oil Substances 0.000 claims description 18
- 208000020670 canker sore Diseases 0.000 claims description 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
- 239000008346 aqueous phase Substances 0.000 claims description 15
- -1 polypropylene Polymers 0.000 claims description 15
- 239000007795 chemical reaction product Substances 0.000 claims description 14
- 239000012299 nitrogen atmosphere Substances 0.000 claims description 14
- 229920000428 triblock copolymer Polymers 0.000 claims description 14
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 12
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims description 11
- 239000010495 camellia oil Substances 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 claims description 8
- 229940063953 ammonium lauryl sulfate Drugs 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 238000001035 drying Methods 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 7
- 241000050051 Chelone glabra Species 0.000 claims description 6
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 claims description 6
- 229920001577 copolymer Polymers 0.000 claims description 5
- 229940105902 mint extract Drugs 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 4
- 240000005373 Panax quinquefolius Species 0.000 claims description 4
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 229910021529 ammonia Inorganic materials 0.000 claims description 2
- 150000001649 bromium compounds Chemical class 0.000 claims description 2
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical compound C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims 1
- DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 7
- 230000006378 damage Effects 0.000 abstract description 5
- 229940079593 drug Drugs 0.000 abstract description 5
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract description 4
- 229940127554 medical product Drugs 0.000 abstract description 2
- 239000000463 material Substances 0.000 description 9
- 210000000214 mouth Anatomy 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 208000025865 Ulcer Diseases 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 6
- 229910021589 Copper(I) bromide Inorganic materials 0.000 description 5
- 230000003115 biocidal effect Effects 0.000 description 5
- NKNDPYCGAZPOFS-UHFFFAOYSA-M copper(i) bromide Chemical compound Br[Cu] NKNDPYCGAZPOFS-UHFFFAOYSA-M 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 231100000397 ulcer Toxicity 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 235000010603 pastilles Nutrition 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 230000005611 electricity Effects 0.000 description 3
- 125000004494 ethyl ester group Chemical group 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 210000004927 skin cell Anatomy 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- PBQVHWFDMNCCIH-KNJAVFAGSA-N (4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;n,n-dimethyl-1-phenothiazin-10-ylpropan-2-amine;n-(4-hydroxyphenyl)acetamide;phosphoric acid;hydrochloride Chemical compound Cl.OP(O)(O)=O.CC(=O)NC1=CC=C(O)C=C1.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1.C([C@H]1C(N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC PBQVHWFDMNCCIH-KNJAVFAGSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000165940 Houjia Species 0.000 description 1
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical group C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- 235000014676 Phragmites communis Nutrition 0.000 description 1
- 206010042566 Superinfection Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 229940037003 alum Drugs 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical group 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Dispersion Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to medical products field, there is provided a kind of mouth ulcer paster easily absorbed and preparation method thereof.The mouth ulcer paster, includes the component of following parts by weight：20 30 parts of active component micro emulsion grain, 30 40 parts of propolis, 10 20 parts of borneol, 15 parts of antiseptic, 46 parts of lubricant, 5 10 parts of sodium carboxymethylcellulose, 26 parts of coating agent.0 10 parts of pH adjusting agent.Containing active component micro emulsion grain in the mouth ulcer paster of the present invention, wherein containing drug ingedient, easily by buccal absorption, so that rapid-action.In addition, in the present invention excessive damage will not be caused to cell containing the antiseptic that antibacterial activity is high, mildness is good.
Description
Technical field
The present invention relates to medical products field, especially, it is related to a kind of mouth ulcer paster easily absorbed and preparation method thereof.
Background technology
Canker sore betides the ulcerative damages illness of mucous membrane of mouth, and sharp ache when canker sore is broken out is local to burn
Substantially, severe patient can also influence diet, speak pain, and daily life is affected greatly.Polytype has been sold on the market at present
Mouth paster.
Patent CN200410060586.7 discloses a kind of mouth ulcer paster, and it is by pastille adhesion layer, fish tail and waterproof layer
Two layers of composition, its pastille adhesion layer is to mix each effective in direct tablet compressing, pastille adhesion layer with adhesion material to be passed through containing active drug
Material medicine ratio of weight and number is indigo naturalis: alum: borneol=0.5~10: 0.5~10: 0.05~2；Material medicine total amount is with gluing
Attached material total amount ratio is 1: 2-8；The dispenser of this drug paste is convenient, and treatment is quick, reduce pain, and several drugses use in conjunction, effect is mutual
Mend, treat stomatocace, with sterilization, anti-inflammatory, analgesic, promotion healing effect；The adhesion layer of pastille adheres to oral cavity
The time, up to 2~4 hours, discharges the medicaments uniformity in preparation, can both play therapeutic action, can protect again on the surface of a wound of ulcer
The surface of a wound.
But the mouth ulcer paster of above-mentioned patent also has certain deficiency, active constituents of medicine can not after paster attaching
Fully by buccal absorption, thus it is slower to take effect.
The content of the invention
In order to solve the above-mentioned technical problem, the invention provides a kind of mouth ulcer paster easily absorbed and its preparation side
Method.Containing active component micro emulsion grain in the mouth ulcer paster of the present invention, wherein containing drug ingedient, easily inhaled by mucous membrane of mouth
Receive, so that rapid-action.In addition, will not be caused excessively to cell containing the antiseptic that antibacterial activity is high, mildness is good in the present invention
Infringement.
To achieve the above object, the invention provides a kind of mouth ulcer paster easily absorbed, including following parts by weight
Component：
20-30 parts of active component micro emulsion grain,
30-40 parts of propolis,
10-20 parts of borneol,
1-5 parts of antiseptic,
4-6 parts of lubricant,
5-10 parts of sodium carboxymethylcellulose,
2-6 parts of coating agent,
0-10 parts of pH adjusting agent.
In the formula of the present invention, containing active component micro emulsion grain, Chinese medicine and western medicine composition are coated with, compared to conventional method
Directly add medicine in formula, its advantage be can quick buccal absorption so that effect is more preferable.Borneol has heat-clearing solution
Poison, effect of swelling and pain relieving.Propolis is as main carriers material, and the adhesiveness with mucous membrane of mouth is good.Simultaneously in inventive formulation
Also antiseptic, can ulcer spot sterilized, prevent wound superinfection.
Preferably, active component micro emulsion grain is includes Chinese medical extract for treating canker sore and for controlling
Treat the W/O/W microemulsion of the Western medicine of canker sore.
Preferably, the Chinese medical extract is selected from mint extract, Baical Skullcap root P.E, Honegsukle flower P.E, pseudo-ginseng and extracted
At least one of thing, American ginseng extract.
Preferably, the Western medicine is at least one of Glu and sodium azulenesulfonate.
The present invention is compounded from Chinese medicine and Western medicine simultaneously, and Western medicine is rapid-action, can quickly alleviating pain stop swollen, and Chinese medicine energy
Enough thoroughly radical cures, both cooperate, and effect is more preferable.
Preferably, the preparation method of the active component micro emulsion grain is：
Chinese medical extract and Western medicine are dissolved in the water, adds after surfactant stirs and aqueous phase solution is made；Will
Aqueous phase solution is added in the tea oil containing Chinese medical extract, Western medicine and surfactant, and Water-In-Oil is made after being sufficiently stirred for
Particle；Finally Water-In-Oil particle is added in the water containing Chinese medical extract, Western medicine and surfactant, divided after being sufficiently stirred for
From the active component micro emulsion grain of obtained W/O/W.
Active component micro emulsion grain made from the above method, it is and each with aqueous phase-oil phase and-three layers of clad structure of aqueous phase
Contain active material (Ginger P.E, hyaluronic acid) in layer water/oil phase, it has the benefit that, a variety of in Skin Cell
With hydroaropic substance (cell liquid, cytoplasm etc.) and lipophilicity substance (cell membrane etc.), when deployed, active component micro emulsion grain
Skin Cell can be successively penetrated into, when meeting water hydroaropic substance, its aqueous layer material is dissolved in wherein, so as to discharge work
Property material；When running into lipophilicity substance, its oil phase layer material is dissolved in wherein, also discharges active material.Therefore it can be abundant
Rapid osmotic enters Skin Cell, promotes to absorb and work.In addition oil phase substance of the invention selects tea oil, tea oil itself
Also there is good anti-oxidant, antibacterial action.
Preferably, the surfactant is neopelex or ammonium lauryl sulfate.
Preferably, the lubricant is selected from least one of stearic acid, magnesium stearate, superfine silica gel powder or talcum powder；Institute
Coating agent is stated for polypropylene for medical article resin.
Preferably, the antiseptic is polycaprolactone, itaconic acid and methacrylic acid -2- (the diformazan ammonia of end group hydroxyl
Base) ethyl ester triblock copolymer.
Preferably, the polycaprolactone of the end group hydroxyl, itaconic acid and methacrylic acid -2- (dimethylamino) ethyl ester
The preparation method of triblock copolymer is：
The polycaprolactone of 8-10 parts by weight end group hydroxyls is dissolved in chloroform, to it under the conditions of nitrogen atmosphere, 0-5 DEG C
It is added dropwise after the bromo isobutyl acylbromide of 0.2-0.4 parts by weight, reaction 16-20h, reaction product is added in absolute methanol and sunk
Form sediment, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), 0.2-0.4 parts by weight cuprous bromides are added,
8-12 parts by weight itaconic acids are added under nitrogen atmosphere, and then the polymerisation 8-12h at 75-85 DEG C adds 10-15 parts by weight
Methacrylic acid -2- (dimethylamino) ethyl ester, is incubated polymerisation 4-6h, reaction product is precipitated, filtered, three are obtained embedding
Section copolymer.
After oral cavity ulcer spot is infected by bacterial, infected cell can secret out of the acidic materials such as lactic acid, so that
So that the infected place in canker sore position is in faintly acid.After oral cavity ulcer spot is not infected or infected place heals, its
Return to again original in neutrality.According to this characteristic, above-mentioned antiseptic has been made in the present inventor.The antiseptic is by three kinds of monomers
(polycaprolactone, itaconic acid and methacrylic acid -2- (dimethylamino) ethyl ester of end group hydroxyl) copolymerization is obtained, wherein, methyl
Acrylic acid -2- (dimethylamino) ethyl esters are due to having antibiotic property with quaternary ammonium salt functional group.Above-mentioned copolymer has following spy
Property：Under weak acid environment, segment where itaconic acid is in electroneutral, the polycaprolactone and methacrylic acid -2- (diformazans at its two ends
Amino) ethyl ester) segment trails, and copolymer is in integrally positive electricity, and now, copolymer has antibiotic property.In neutral environment, clothing health
Middle segment where acid is in negative electricity, and the polycaprolactone at its two ends and methacrylic acid -2- (dimethylamino) ethyl ester) segment is in
Positive electricity, under electrostatic interaction, antibiotic property is greatly reduced.Compared with other classical antibacterial agents, antiseptic of the invention is only in mouth
Chamber ulcer spot is infected in can just show preferable antibiotic property after faintly acid, for not being infected or removing metainfective
Position, without antibiotic property.Because antiseptic can also be damaged while antibacterial to human body cell, and the antibacterial of the present invention
Antibacterial action can not occur rapidly after bacterial destruction for agent, and excessively injury will not be caused to human body cell.
Preferably, the antiseptic is nano-scale particle.
A kind of preparation method of the mouth ulcer paster easily absorbed, comprises the following steps：
1) active component micro emulsion grain is prepared；
2) add after being well mixed active component micro emulsion grain, propolis, borneol, antiseptic, lubricant, sodium carboxymethylcellulose
Water is soaked, and addition pH adjusting agent regulation pH value is 7-8, carries out tabletting；
3) finally it is coated with coating agent, finished product after drying process.
The invention has the advantages that：Containing active component micro emulsion grain in the mouth ulcer paster of the present invention, wherein
Containing drug ingedient, easily by buccal absorption, so that rapid-action.In addition, containing antibacterial activity height, mildness in the present invention
Good antiseptic, will not cause excessive damage to cell.
Embodiment
Embodiments of the invention are described in detail below, but the present invention can be limited and covered according to claim
Multitude of different ways implement.
Embodiment 1
A kind of mouth ulcer paster easily absorbed, includes the component of following parts by weight：
25 parts of active component micro emulsion grain,
35 parts of propolis,
15 parts of borneol,
3 parts of antiseptic,
5 parts of lubricant,
8 parts of sodium carboxymethylcellulose,
4 parts of coating agent,
Appropriate pH adjusting agent.
Wherein, active component micro emulsion grain is includes Chinese medical extract for treating canker sore and for treating
The W/O/W microemulsion of the Western medicine of canker sore.Its preparation method is：Chinese medical extract and Western medicine are dissolved in the water, plus
Enter and aqueous phase solution is made after surfactant (neopelex) stirs；Aqueous phase solution is added to containing Chinese medicine
In the tea oil of extract, Western medicine and surfactant (neopelex), Water-In-Oil particle is made after being sufficiently stirred for；
Water-In-Oil particle is finally added to the water containing Chinese medical extract, Western medicine and surfactant (neopelex)
In, the active component micro emulsion grain that W/O/W is made is separated after being sufficiently stirred for.
The Chinese medical extract is mint extract, Baical Skullcap root P.E, the mixture of Honegsukle flower P.E.The Western medicine is
Glu and sodium azulenesulfonate.
The lubricant is stearic acid；The coating agent is polypropylene for medical article resin.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 9 parts by weight end group hydroxyls is dissolved in chloroform
In, it is added dropwise under the conditions of nitrogen atmosphere, 2 DEG C to it after bromo isobutyl acylbromide of 0.3 parts by weight, reaction 18h, reaction product is added
Add in absolute methanol and precipitated, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.3 parts by weight cuprous bromide, adds 10 parts by weight itaconic acids, polymerisation 10h, is then added at 80 DEG C under nitrogen atmosphere
12 weight parts of methacrylic acid -2- (dimethylamino) ethyl esters, are incubated polymerisation 5h, reaction product are precipitated, filtered, is obtained
To triblock copolymer.
The preparation method of the above-mentioned mouth ulcer paster easily absorbed, comprises the following steps：
1) active component micro emulsion grain is prepared；
2) add after being well mixed active component micro emulsion grain, propolis, borneol, antiseptic, lubricant, sodium carboxymethylcellulose
Water is soaked, and addition pH adjusting agent regulation pH value is 7.5, carries out tabletting；
3) finally it is coated with coating agent, finished product after drying process.
Embodiment 2
A kind of mouth ulcer paster easily absorbed, includes the component of following parts by weight：
20 parts of active component micro emulsion grain,
30 parts of propolis,
10 parts of borneol,
Antiseptic part,
Lubricant part,
5 parts of sodium carboxymethylcellulose,
2 parts of coating agent,
Appropriate pH adjusting agent.
Wherein, active component micro emulsion grain is includes Chinese medical extract for treating canker sore and for treating
The W/O/W microemulsion of the Western medicine of canker sore.Its preparation method is：Chinese medical extract and Western medicine are dissolved in the water, plus
Enter and aqueous phase solution is made after surfactant (ammonium lauryl sulfate) stirs；Aqueous phase solution is added to and carried containing Chinese medicine
In the tea oil for taking thing, Western medicine and surfactant (ammonium lauryl sulfate), Water-In-Oil particle is made after being sufficiently stirred for；Finally
Water-In-Oil particle is added in the water containing Chinese medical extract, Western medicine and surfactant (ammonium lauryl sulfate), fully
The active component micro emulsion grain that W/O/W is made is separated after stirring.
The Chinese medical extract is a kind of reed mentioned in ancient books extract, Honegsukle flower P.E, Notogineng Extract, the mixing of American ginseng extract
Thing.The Western medicine is Glu.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 8 parts by weight end group hydroxyls is dissolved in chloroform
In, it is added dropwise under the conditions of nitrogen atmosphere, 0 DEG C to it after bromo isobutyl acylbromide of 0.2 parts by weight, reaction 16h, reaction product is added
Add in absolute methanol and precipitated, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.2 parts by weight cuprous bromide, adds 8 parts by weight itaconic acids, polymerisation 12h, is then added at 75 DEG C under nitrogen atmosphere
10 weight parts of methacrylic acid -2- (dimethylamino) ethyl esters, are incubated polymerisation 6h, reaction product are precipitated, filtered, is obtained
To triblock copolymer.
The preparation method of the above-mentioned mouth ulcer paster easily absorbed, comprises the following steps：
1) active component micro emulsion grain is prepared；
2) add after being well mixed active component micro emulsion grain, propolis, borneol, antiseptic, lubricant, sodium carboxymethylcellulose
Water is soaked, and addition pH adjusting agent regulation pH value is 7, carries out tabletting；
3) finally it is coated with coating agent, finished product after drying process.
Embodiment 3
A kind of mouth ulcer paster easily absorbed, includes the component of following parts by weight：
30 parts of active component micro emulsion grain,
40 parts of propolis,
20 parts of borneol,
5 parts of antiseptic,
6 parts of lubricant,
10 parts of sodium carboxymethylcellulose,
6 parts of coating agent,
Appropriate pH adjusting agent.
Wherein, active component micro emulsion grain is includes Chinese medical extract for treating canker sore and for treating
The W/O/W microemulsion of the Western medicine of canker sore.Its preparation method is：Chinese medical extract and Western medicine are dissolved in the water, plus
Enter and aqueous phase solution is made after surfactant (neopelex) stirs；Aqueous phase solution is added to containing Chinese medicine
In the tea oil of extract, Western medicine and surfactant (neopelex), Water-In-Oil particle is made after being sufficiently stirred for；
Water-In-Oil particle is finally added to the water containing Chinese medical extract, Western medicine and surfactant (neopelex)
In, the active component micro emulsion grain that W/O/W is made is separated after being sufficiently stirred for.
The Chinese medical extract is mint extract, Baical Skullcap root P.E, Honegsukle flower P.E, Notogineng Extract, American Ginseng
The mixture of extract.The Western medicine is sodium azulenesulfonate.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 10 parts by weight end group hydroxyls is dissolved in chlorine
In imitative, it is added dropwise under the conditions of nitrogen atmosphere, 5 DEG C to it after bromo isobutyl acylbromide of 0.4 parts by weight, reaction 20h, by reaction product
Precipitated added in absolute methanol, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.4 parts by weight cuprous bromide, adds 12 parts by weight itaconic acids, polymerisation 8h, is then added at 85 DEG C under nitrogen atmosphere
15 weight parts of methacrylic acid -2- (dimethylamino) ethyl esters, are incubated polymerisation 6h, reaction product are precipitated, filtered, is obtained
To triblock copolymer.
The preparation method of the above-mentioned mouth ulcer paster easily absorbed, comprises the following steps：
1) active component micro emulsion grain is prepared；
2) add after being well mixed active component micro emulsion grain, propolis, borneol, antiseptic, lubricant, sodium carboxymethylcellulose
Water is soaked, and addition pH adjusting agent regulation pH value is 8, carries out tabletting；
3) finally it is coated with coating agent, finished product after drying process.
Embodiment 4
A kind of mouth ulcer paster easily absorbed, includes the component of following parts by weight：
22 parts of active component micro emulsion grain,
38 parts of propolis,
12 parts of borneol,
4 parts of antiseptic,
5 parts of lubricant,
6 parts of sodium carboxymethylcellulose,
3 parts of coating agent,
Appropriate pH adjusting agent.
Wherein, active component micro emulsion grain is includes Chinese medical extract for treating canker sore and for treating
The W/O/W microemulsion of the Western medicine of canker sore.Its preparation method is：Chinese medical extract and Western medicine are dissolved in the water, plus
Enter and aqueous phase solution is made after surfactant (neopelex) stirs；Aqueous phase solution is added to containing Chinese medicine
In the tea oil of extract, Western medicine and surfactant (neopelex), Water-In-Oil particle is made after being sufficiently stirred for；
Water-In-Oil particle is finally added to the water containing Chinese medical extract, Western medicine and surfactant (neopelex)
In, the active component micro emulsion grain that W/O/W is made is separated after being sufficiently stirred for.
The Chinese medical extract is Baical Skullcap root P.E, the mixture of Honegsukle flower P.E.The Western medicine is Glu
And sodium azulenesulfonate.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 8 parts by weight end group hydroxyls is dissolved in chloroform
In, it is added dropwise under the conditions of nitrogen atmosphere, 0 DEG C to it after bromo isobutyl acylbromide of 0.3 parts by weight, reaction 18h, reaction product is added
Add in absolute methanol and precipitated, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.3 parts by weight cuprous bromide, adds 8-12 parts by weight itaconic acids, polymerisation 9h, Ran Houjia at 80 DEG C under nitrogen atmosphere
Enter 14 weight parts of methacrylic acid -2- (dimethylamino) ethyl esters, be incubated polymerisation 5.5h, reaction product is precipitated, mistake
Filter, obtains triblock copolymer.
The preparation method of the above-mentioned mouth ulcer paster easily absorbed, comprises the following steps：
1) active component micro emulsion grain is prepared；
2) add after being well mixed active component micro emulsion grain, propolis, borneol, antiseptic, lubricant, sodium carboxymethylcellulose
Water is soaked, and addition pH adjusting agent regulation pH value is 7.5, carries out tabletting；
3) finally it is coated with coating agent, finished product after drying process.
Embodiment 5
A kind of mouth ulcer paster easily absorbed, includes the component of following parts by weight：
28 parts of active component micro emulsion grain,
32 parts of propolis,
16 parts of borneol,
4 parts of antiseptic,
6 parts of lubricant,
8 parts of sodium carboxymethylcellulose,
5 parts of coating agent,
Appropriate pH adjusting agent.
Wherein, active component micro emulsion grain is includes Chinese medical extract for treating canker sore and for treating
The W/O/W microemulsion of the Western medicine of canker sore.Its preparation method is：Chinese medical extract and Western medicine are dissolved in the water, plus
Enter and aqueous phase solution is made after surfactant (ammonium lauryl sulfate) stirs；Aqueous phase solution is added to and carried containing Chinese medicine
In the tea oil for taking thing, Western medicine and surfactant (ammonium lauryl sulfate), Water-In-Oil particle is made after being sufficiently stirred for；Finally
Water-In-Oil particle is added in the water containing Chinese medical extract, Western medicine and surfactant (ammonium lauryl sulfate), fully
The active component micro emulsion grain that W/O/W is made is separated after stirring.
The Chinese medical extract is mint extract, the mixture of Baical Skullcap root P.E.The Western medicine be Glu and
Sodium azulenesulfonate.
The nano-class antibacterial agent particle be in end group hydroxyl polycaprolactone, itaconic acid and methacrylic acid -2-
The triblock copolymer of (dimethylamino) ethyl ester, preparation method is：The polycaprolactone of 8 parts by weight end group hydroxyls is dissolved in chloroform
In, it is added dropwise under the conditions of nitrogen atmosphere, 1 DEG C to it after bromo isobutyl acylbromide of 0.2 parts by weight, reaction 16h, reaction product is added
Add in absolute methanol and precipitated, obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), added
0.2 parts by weight cuprous bromide, adds 8 parts by weight itaconic acids, polymerisation 9h, then adds 12 at 80 DEG C under nitrogen atmosphere
Weight parts of methacrylic acid -2- (dimethylamino) ethyl ester, is incubated polymerisation 4.5h, reaction product is precipitated, filtered, is obtained
To triblock copolymer.
The preparation method of the above-mentioned mouth ulcer paster easily absorbed, comprises the following steps：
1) active component micro emulsion grain is prepared；
2) add after being well mixed active component micro emulsion grain, propolis, borneol, antiseptic, lubricant, sodium carboxymethylcellulose
Water is soaked, and addition pH adjusting agent regulation pH value is 7, carries out tabletting；
3) finally it is coated with coating agent, finished product after drying process.
The preferred embodiments of the present invention are the foregoing is only, are not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.Within the spirit and principles of the invention, that is made any repaiies
Change, equivalent substitution, improvement etc., should be included in the scope of the protection.
Claims (10)
1. a kind of mouth ulcer paster easily absorbed, it is characterised in that include the component of following parts by weight：
20-30 parts of active component micro emulsion grain,
30-40 parts of propolis,
10-20 parts of borneol,
1-5 parts of antiseptic,
4-6 parts of lubricant,
5-10 parts of sodium carboxymethylcellulose,
2-6 parts of coating agent,
0-10 parts of pH adjusting agent.
2. a kind of mouth ulcer paster easily absorbed according to claim 1, it is characterised in that the active component micro emulsion
Grain is includes the Chinese medical extract for treating canker sore and the W/O/W of the Western medicine for treating canker sore is micro-
Emulsion.
3. a kind of mouth ulcer paster easily absorbed according to claim 2, it is characterised in that the Chinese medical extract choosing
From at least one of mint extract, Baical Skullcap root P.E, Honegsukle flower P.E, Notogineng Extract, American ginseng extract.
4. a kind of mouth ulcer paster easily absorbed according to claim 2, it is characterised in that the Western medicine is L- paddy ammonia
At least one of acid amides and sodium azulenesulfonate.
5. a kind of mouth ulcer paster easily absorbed according to claim 2, it is characterised in that the active component micro emulsion
Grain preparation method be：
Chinese medical extract and Western medicine are dissolved in the water, adds after surfactant stirs and aqueous phase solution is made；By aqueous phase
Solution is added in the tea oil containing Chinese medical extract, Western medicine and surfactant, and Water-In-Oil particle is made after being sufficiently stirred for；
Finally Water-In-Oil particle is added in the water containing Chinese medical extract, Western medicine and surfactant, system is separated after being sufficiently stirred for
Obtain the active component micro emulsion grain of W/O/W.
6. a kind of mouth ulcer paster easily absorbed according to claim 5, it is characterised in that the surfactant is
Neopelex or ammonium lauryl sulfate.
7. a kind of mouth ulcer paster easily absorbed according to claim 1, it is characterised in that the lubricant is selected from hard
At least one of resin acid, magnesium stearate, superfine silica gel powder or talcum powder；The coating agent is polypropylene for medical article resin.
8. a kind of mouth ulcer paster easily absorbed according to claim 1, it is characterised in that the antiseptic is end group
The triblock copolymer of the polycaprolactone of hydroxyl, itaconic acid and methacrylic acid -2- (dimethylamino) ethyl ester.
9. a kind of mouth ulcer paster easily absorbed according to claim 8, it is characterised in that the end group hydroxyl
The preparation method of the triblock copolymer of polycaprolactone, itaconic acid and methacrylic acid -2- (dimethylamino) ethyl ester is：
The polycaprolactone of 8-10 parts by weight end group hydroxyls is dissolved in chloroform, is added dropwise under the conditions of nitrogen atmosphere, 0-5 DEG C to it
After the bromo isobutyl acylbromide of 0.2-0.4 parts by weight, reaction 16-20h, reaction product is added in absolute methanol and precipitated,
Obtain being modified polycaprolactone；Modified polycaprolactone is dissolved in dimethyl sulfoxide (DMSO), 0.2-0.4 parts by weight cuprous bromides are added,
8-12 parts by weight itaconic acids are added under nitrogen atmosphere, then the polymerisation 8-12h at 75-85 DEG C adds 10-15 parts by weight first
Base acrylic acid -2- (dimethylamino) ethyl ester, is incubated polymerisation 4-6h, reaction product is precipitated, filtered, three block is obtained
Copolymer.
10. a kind of preparation method of the mouth ulcer paster of easy absorption according to one of claim 1-9, it is characterised in that
Comprise the following steps：
1) active component micro emulsion grain is prepared；
2) add water profit after being well mixed active component micro emulsion grain, propolis, borneol, antiseptic, lubricant, sodium carboxymethylcellulose
Wet, addition pH adjusting agent regulation pH value is 7-8, carries out tabletting；
3) finally it is coated with coating agent, finished product after drying process.
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Inventor after: Li Xiaoqing Inventor after: Jiang Yahong Inventor after: Wu Miao Inventor before: Wu Miao |
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Effective date of registration: 20231023 Address after: 201114 room 304-9, building 10, No. 2168, Chenhang highway, Minhang District, Shanghai Patentee after: Shanghai Yaoda Biotechnology Co.,Ltd. Patentee after: Lingyao Biotechnology (Shanghai) Co.,Ltd. Address before: 201111 room e268, 2nd floor, building 3, 2118 Guanghua Road, Minhang District, Shanghai Patentee before: Shanghai Yaoda Biotechnology Co.,Ltd. |