AT15430U1 - Dental agent based on hyaluronan and octenidine dihydrochloride - Google Patents

Abstract

The invention relates to a dental agent based on hyaluronan and octenidine dihydrochloride characterized in that it contains physiologically acceptable salt of hyaluronanic acid and octenidine dihydrochloride in a weight ratio of 100: 1 to 2000: 1, the agent being in the form of lyophilisate or gel.

Description

description

DENTAL MEDIUM BASED ON HYALURONANE AND OCTENIDINE DIHYDROCHLORIDE TECHNICAL FIELD

The technical solution relates to a dental agent in the form of lyophilisate or gel based on physiologically acceptable salt of hyaluronic acid and octenidine dihydrochloride as antiseptic, optionally based on a further polysaccharide or other polysaccharides and a physiologically acceptable inorganic salt for treatment and prevention of dental complications, for example, for the treatment and prevention of alveolar osteitis, for the treatment of gingival injury after scaling, for the treatment of oral mucosal wounds or tongue wounds, or for other types of wounds and injuries in the oral cavity.

STATE OF THE ART

Alveolar osteitis (alveolitis sicca, dry alveolitis, dry tooth bed, fibrinolytic alveolitis, post-extraction syndrome) is a complication after tooth extraction in which either no coagulum creation occurs, or in which disintegration of the coagulum occurs. Dental beds in the lower jaw are the most affected. The tooth bed is empty, gray colored, very painful. The incidence rate of alveolar osteitis after tooth extractions of wisdom teeth is up to 35%.

Alveolar osteitis means partial or total disintegration of the coagulum due to fibrinolysis (by the conversion of plasminogen to plasmin) with microbial action on the bed wall of the extraction wound. Clinically, it is particularly characterized by intense analgesic pain that is difficult to anesthetize, not only at the extraction site, but also throughout the jaw or ear area. There is no exudation, the tooth bed is empty, with no coagulum, or it is filled with food residues.

The treatment consists in the irrigation (rinsing) and excochleation of the extraction wound to remove the necrotic parts of the bed, bloating of the wound and reintroduction of wound healing. It is also possible to use an intra-alveolar remedy after exo-chill and rinse the bed. Preventive measures are also very important, including several options for limiting the development of alveolar osteitis, using either total or local remedies.

[0005] Prophylactic total remedies include steroids and antibiotics. Antibiotic prophylaxis is one of the most prevalent methods of preventive treatment, providing a safeguard for an antimicrobial environment that makes disease development impossible. One-time pre-surgical administration is preferred to ensure systemic antibiotic coverage during surgery.

Mostly, linkosamide (clindamycin), penicillin antibiotics (amoxicillin) and tetracycline are recommended. In the case of antibiotics, the indications can not be strictly limited, yet prophylactic administration of the antibiotics is considered to be useful in impacted (non-penetrated) wisdom teeth, where a protracted, complicated procedure requiring extensive bone preparation is desired.

Locally administered remedies are administered in two forms, as antiseptic oral rinses, or intra-alveolar. Rinses are taken with isotonic saline, hydrogen peroxide (3%), hexetidine and chlorhexidine based.

Chlorhexidine is taken in the form of solutions (in concentration of 0.2 and 0.12%) and gel (in concentration of 1 and 0.5%), now also in the form of tablets and spray.

As an advantage of chlorhexidine, the binding to the surface structures of epithelial cells of the oral mucosa is considered. After rinsing, about 30% remains bound. This amount is gradually dissolved in the saliva and the effect is prolonged. Chlorhexidine is most recommended in the form of oral irrigations, just prior to surgery. Analog purging is practiced twice daily within seven postoperative days. The effect of irrigation, where there is almost 50% reduction in the incidence of alveolitis, has been demonstrated by numerous studies.

Intra-alveolar prophylaxis consists in application of an antiseptic / antimicrobial agent directly into the extraction wound. A very suitable method is the application of the chlorhexidine gel into the extraction wound at the end of the procedure. The gel is applied only in a single dose.

As a further variant, a so-called open method can be used, in which the antiseptic effect of iodoform is exploited. The open method consists in leaving the free-open wound, which is tamponated in its crown part with an iodoform drainage. The iodoform drainage protects by its antiseptic effect the blood clot with the subsequent wound healing. The drainage is always exchanged for a shorter one after 3 to 5 days, with the wound only being rinsed with a saline solution. After two weeks, the drainage should be removed. Disadvantages of this method are the need for multiple controls on iodoform drainage, which significantly affects the patient's postoperative comfort, as well as the unpleasant odor of iodoform.

Another possibility is the introduction of a framykoin (Pamycon) impregnated drainage or spreading of the wound with benzocaine powder. As a significant analgesic and antiseptic for use in dentistry is the clove oil with the active ingredient eugenol.

In veterinary medicine can be seen relatively often soft tissue pathology in the oral cavity, which is caused by excessive formation and attachment of tartar, especially in dogs and cats. The cause of the overgrowth is usually not only a genetic predisposition, but also the composition of the feed ration and the nature (possibly complete absence) of the oral and oral care of the grower considered. The presence of calculus may be subdivided according to the localization on supragingival and subgingival. Tartar, which is supragingival, deposits on the neck of the tooth above the gum line and can cover a substantial tooth surface. Tartar, which is subgingival, is formed under the gingival margin in the gingival groove or periodontal pocket. It forms deposits on root walls that can only be eliminated problematically. Tartar can also be removed by ultrasound, manually or by a combination of both methods. In veterinary medicine, the ultrasonic cleaning of the teeth is performed in general anesthesia in most cases. With the help of an ultrasound device, the removal of coarse and hard calculus deposits is possible.

When using the ultrasound device may damage the soft tissue in the oral cavity and therefore it is convenient to treat the damaged gums and support healing. This can be done by means of rinsing with antiseptic solutions, gels or pastes with disinfectant action (in human medicine for example with gels Gengigel, Corsodyl 1%, Curasept ADS Periodontal, Phyteneo Neocide, in veterinary medicine for example with Gelen Gingisan a.u.v, Stomodine). Some animal products also contain natural products with antibacterial or healing benefits (for example, Hexocare Tooth Gel, Stomaclean TM, etc.). Hyaluronic acid-based mouth gel provides active protection against gum disease and supports natural healing of inflamed and damaged tissues in the oral cavity. Hyaluronan also stimulates formation of a new tissue. Also in tooth extraction (whether it is abnormally long time persistent milk teeth, or whether it is tooth trauma, if it is a large tooth decay) is as a result of surgery, the tissue integrity injured and in healing it then too

Inflammation may occur. Here is another possible indication for using antiseptic and healing agents to support faster gum regeneration.

The utilization of hyaluronan in dentistry for the healing of mucous membranes is known. For example, hyaluronan provides the basis for Gengigel range agents designed for preventive and supportive care in the management of conditions associated with gingivitis and tooth-brush inflammation. In combination with bovine colposing, hyaluronan is a component of the Hypro-sorb Z agent, which acts as a hemostatic agent after tooth extraction. Octenidine dihydrochloride is used in oral hygiene as a component of the mouthwash octenidol, but it is also a component of skin antisepsis and wound healing agents, for example octenept, octeniline and the like.

European Patent Application EP 2401914 describes an antimicrobial mixture for antisepsis of wounds and mucous membranes. The agent contains bispyridinium alkane (octenidine dihydrochloride), a humectant and water. As a preferred humectant is glycerol. The patent application mentions no other forms of the agent other than solution. The octenidine dihydrochloride content is higher in proportion to the moistening component, which may result in prolonged application of irritation to mucous membranes or skin.

International Patent Application WO02009032406 describes a means of curing and preventing xerostomia and the associated pathologies, for example, bacterial infection, tooth decay, and the like. It is a mixture containing surfactant, antimicrobial component and adhesive. The remedy is available in the form of a toothpaste, a mouthwash or oral spray. A disadvantage of this solution is a high content of the antiseptic, which can have an irritating effect, therefore, such solutions are only suitable for a short-term application.

International Patent Application W02006105196 describes a mixture whose main component is diindolylmethane, which may be in combination with another anti-inflammatory or antibacterial substance. The agent may be available in the form of capsules, tablets, toothpaste, mouth gel, mouthwash, lozenges. The agent has been used to heal an injured oral mucosa, for example in periodontitis or gingivitis, for prevention and bone loss arrest (osteopenia, osteoporosis) or to cure chronic mucosal inflammation.

International Patent Application WO2012174076 describes a polymetallic complex and suitable carrier for oral use. It is a mixture of a multifunctional compound (for example, polycarboxylic acids, polyamino acids, etc.) of two or more elements, and optionally other active components. A preferred complex is a copper-zinc malonate. Cheap forms of this remedy are solution, foam, sticks and ointment.

International Patent Application WO 2012073191 describes a mucosal regeneration agent containing cholinal foskerate and high molecular weight hyaluronan (0.8-4 MDa). In addition, it may contain other active components, for example silver, aloe vera, allantoin, chlorhexidine or bansalkonium chloride. European patent application EP 2520279 describes a medical device for dental application based on a thermo-reversible gel. The product consists of water, topically active substance, thickening agent and a slimy-adhesive component, which improves the adhesion of the agent to the oral mucosa or tooth enamel, thus prolonging the whereabouts at the site of use. Slimy-adhesive component is hyaluronic acid or its salt, poloxamer works as a thickening agent, and active ingredient comes from a disinfectant, fluoride salt, antioxidant, local anesthetic, antibiotic, or anti-inflammatory drug group. International Patent Application WO 2013079443 describes a mammalian bone regeneration agent, preferably for human jaw bones, for example in periodontal disease. The agent consists of binder, granules and hyaluronan. As granules is here

Aragonite, bioceramics, bioglass or allogeneic, autogenous or xenogenous bone substance used. The binder used is collagen, or fibrin glue.

International patent applications WO 201329796, WO 2013029797 and WO 2013029798 describe a multilayer wound dressing containing textile layers, activated carbon and another specific layer. It may be either a hydrocolloid or an air-permeable layer. Hyaluronan can be used as the hydrocolloid. The agent may further contain an antiseptic or other active (for example, allantoin, bromelain, riboflavin, etc.).

BEING THE TECHNICAL SOLUTION

The technical solution relates to a dental agent hyaluronan and Octenidindihyd-rochloridsbasis, which is characterized by having a physiologically acceptable salt of hyaluronic acid and octenidine dihydrochloride in a weight ratio of 100: 1 to 2000: 1, preferably 400: 1 to 800: 1, more preferably 500: 1, being in the form of lyophilisate or gel.

The above-mentioned weight ratio 100: 1 to 2000: 1 of the two active components of the composition represents a range which ensures both the safety and the effectiveness of the composition according to the invention.

The dental agent in the form of lyophilisate or gel has the advantage that it is easily manipulatable and in the form of lyophilisate has an adapted shape and the possibility of further shaping into the shape of a tampon as needed according to e.g. Form of the extraction wound after tooth extraction. Thanks to the adhesiveness of hyaluronan, it remains very well and longer in the wound or on the oral mucosa.

The agent according to the technical solution of the present utility model in the form of lyophilisate and gel can be very well prepared so that it has a precise content of octenidine dihydrochloride, which is in the range in which it is effective, but not yet is lovely.

In the above-mentioned preferred weight ratio of 400: 1 to 800: 1, more preferably 500: 1, there is no injury to the wound healing and at the same time the efficiency remains very high both against G +, and bacteria and yeasts.

The agent according to the technical solution of the present utility model in the form of gel can be prepared very well so that it has a pH which corresponds to the pH of the saliva of the target group of mammals, for example of dogs and cats , which supports the compatibility with the environment and thus the slower degradation from the application site.

According to a preferred embodiment of the technical solution of the utility model, the physiologically acceptable salt of hyaluronic acid is selected on average from the group of alkali metal ions or alkaline earth ions, advantageously Na +, K +, Ca 2+ or Mg 2+.

Further, according to a preferred embodiment of the technical solution of the utility model, the molecular weight of the physiologically acceptable salt of hyaluronic acid on average from 2 x 105 to 2.5 x 106 g / mol, preferably from 1 x 106 to 2.5 x 106 g / mol due to the higher moisture retention capacity, or the slower degradation from the wound space.

According to an advantageous development of the technical solution of the utility model, the agent preferably further contains at least one auxiliary polysaccharide and / or at least one physiologically acceptable inorganic salt, which is suitable for the healing and prevention of alveolar osteitis or other complications after dental extraction in the dental Practice, or for healing of other types of wounds and mucosal injuries, for example, for the treatment of gums after calculus removal apply. The auxiliary polysaccharide is preferably selected from carboxymethyl cellulose (CMC), hydroxyethylene cellulose (HEC), hydroxypropylmethyl cellulose (HPMC), alginate or polyvinyl pyrrolidone (PVP) containing group. According to yet another advantageous development of the technical solution of the utility model, the weight ratio of hyaluronan to auxiliary polysaccharide is from 80:20 to 20:80, preferably from 75:25 to 40:60.

As a physiologically acceptable salt is preferably calcium chloride, which has a dual function, on the one hand, the eventual hemostasis of the wound, on the other hand, the emergence of calcium salt of hyaluronic acid, which has a longer half-life as sodium salt supports. Preferred concentration is by the mutual ratio of the carboxyl groups of hyaluronan and calcium ions, which should be within the range of 1: 1 to 1: 0.1, advantageously of 1: 0.4.

The total concentration of polysaccharides on average according to the technical solution of the utility model is 1 to 5 wt.%, Preferably 4 to 5 wt.% In the gel.

According to a development of the technical solution of the utility model, the agent in the form of tampon is present, which consists of lyophilisate.

For the Lyophilisatausbildung also starting solutions in concentration 1 to 5 wt.% Are suitable, but a particularly preferred range is 2 to 3.5 wt.%. The most favorable concentration in terms of formability and, at the same time, the duration of the wound remains at a concentration of 2.5% by weight, in the case of hyaluronan with Mw in the range from 1.5 to 1.8 × 10 6 g / mol ,

The term "total concentration of the polysaccharides" describes the total concentration of the physiologically acceptable hyaluronic acid salt and all other auxiliary polysaccharides present on average according to the technical solution of the utility model in the form of gel. It is stated in% by weight.

EMBODIMENTS OF THE TECHNICAL SOLUTION EXAMPLE 1

Lyophilisate with hyaluronan, octenidine dihydrochloride and calcium chloride First pipet 16 μΙ of 10% solution of octenidine dihydrochloride in ethanol into 24.271 ml of injection water, then add 92 mg of calcium chloride dihydrate and mix the solution thoroughly. 625 mg of sodium hyaluronan having a molecular weight of 1.78 × 10 6 g / mol are gradually poured into this solution, with constant mixing, and it is thoroughly stirred. It is recommended to let the solution bubble through afterwards. The total concentration of polysaccharides in the starting solution is thus 2.5% by weight. The resulting viscous solution is dosed in doses of 1.2 ml in PE blisters with Ovalformgrübchen. The filled blister is placed in a lyophilizer, frozen and, after lyophilization, optionally frozen in a freezer box at temperature below -50 ° C, and then placed in the lyophilizer and freeze-dried. The blister is then closed with a paper wrapper and the lyophilisates are sterilized with ethylene oxide. Lyophilisates are intended for the treatment or prevention of alveolar osteitis after tooth extraction and they are deformable according to current needs, for example, depending on the Kavitätsgrösse. It is possible, for example, to alter the lyophilizate to a smaller size with a scalpel, for example platelets and to treat other injuries of the oral mucosa, for example the aphthae. EXAMPLE 2

Lyophilisate with hyaluronan and octenidine dihydrochloride.

21 μΙ of 10% solution of octenidine dihydrochloride in ethanol is pipetted into 24.171 ml of injection water and the solution is thoroughly mixed. 812.5 mg of sodium hyaluronan having a molecular weight of 1 × 10 6 g / mol are gradually poured into this solution, with constant mixing, and it is thoroughly stirred. It is recommended to let the solution bubble through afterwards. The total concentration of polysaccharides in the starting solution is thus 3.25% by weight. The resulting viscous solution is dosed in doses of 1.2 ml in PE blisters with Ovalformgrübchen. The filled blister is placed in a lyophilizer, frozen and, after lyophilization, optionally frozen in a freezer box at temperature below -50 ° C, and then placed in the lyophilizer and freeze-dried. The blister is then closed with a paper wrapper and the lyophilisates are sterilized with ethylene oxide. Lyophilisates are intended for the treatment or prevention of alveolar osteitis after tooth extraction and are malleable according to current needs, for example, depending on the size of the cavity. It is possible, for example, to alter the lyophilizate to a smaller size with a scalpel, for example platelets and to treat other injuries of the oral mucosa, for example the aphthae. EXAMPLE 3

Lyophilisate with hyaluronan, octenidine dihydrochloride, calcium chloride and hydroxyethylcellulose. 13 μΙ of 10% solution of octenidine dihydrochloride in ethanol is pipetted into 24.703 ml of injection water, then 37 mg of calcium chloride dihydrate are added and the solution thoroughly mixed. 150 mg of hydroxyethylcellulose and 100 mg of sodium hyaluronan having a molecular weight of 2.5 × 10 6 g / mol are gradually poured into this solution, with constant mixing, and the solution is thoroughly stirred. It is recommended to let the solution bubble through afterwards. The total concentration of polysaccharides in the starting solution is thus 1% by weight. The resulting viscous solution is dosed in doses of 1.2 ml in PE blisters with Ovalformgrübchen. The filled blister is placed in a lyophilizer, frozen and, after lyophilization, optionally frozen in a freezer box at temperature below -50 ° C, and then placed in the lyophilizer and freeze-dried. The blister is then closed with a paper wrapper and the lyophilisates are sterilized with ethylene oxide. Lyophilisates are intended for the treatment or prevention of alveolar osteitis after tooth extraction and are malleable according to current needs, for example, depending on the size of the cavity. It is possible, for example, to alter the lyophilizate to a smaller size with a scalpel, for example platelets and to treat other injuries of the oral mucosa, for example the aphthae. EXAMPLE 4

Lyophilisate with hyaluronan, octenidine dihydrochloride, calcium chloride and hydroxypropyl-methyl-cellulose (HPMC) 6 μΙ of 10% solution of octenidine dihydrochloride in ethanol is pipetted into 23.708 ml of injection water, then 37 mg of calcium chloride dihydrate are added and the solution thoroughly mixed. 250 mg HPMC and 1 g sodium hyaluronan having a molecular weight of 0.2 × 10 6 g / mol are gradually poured into this solution while mixing continuously, and the solution is thoroughly stirred. It is recommended to let the solution bubble through afterwards. The total concentration of polysaccharides in the starting solution is thus 5% by weight. The resulting viscous solution is dosed in doses of 1.2 ml in PE blisters with Ovalformgrübchen. The filled blister is placed in a lyophilizer, frozen and, after lyophilization, optionally frozen in a freezer box at temperature below -50 ° C, and then placed in the lyophilizer and freeze-dried. The blister is then closed with a paper wrapper and the lyophilisates are sterilized with ethylene oxide. Lyophilisates are intended for the treatment or prevention of alveolar osteitis after tooth extraction and are malleable according to current needs, for example, depending on the size of the cavity. It is possible, for example, to alter the lyophilizate to a smaller size with a scalpel, for example platelets and to treat other injuries of the oral mucosa, for example the aphthae. EXAMPLE 5

Gel with hyaluronan and octenidine dihydrochloride 8 μΙ of 10% solution of octenidine dihydrochloride in ethanol is pipetted into 23.688 ml of injection water and the solution thoroughly mixed. 1.25 g of sodium hyaluronan having a molecular weight of 0.2 × 10 6 g / mol are gradually added to this solution, with constant mixing, and the solution is thoroughly stirred again. The resulting viscous solution is dosed into suitable casings, for example in glass vials, in tubes or hypodermic syringes. Then it is sterilized with moist heat. The total concentration of polysaccharides in the gel is thus 5% by weight. The gel is intended for the treatment of gingiva after removal of tartar, for the treatment or prevention of alveolar osteitis or for the treatment of other oral mucosal or skin lesions, and also in the case of a microbial infection. EXAMPLE 6

Gel with Hyaluronan, Octenidine Dihydrochloride, Calcium Chloride and Polyvinylpyrrolidone 16 μL of 10% solution of octenidine dihydrochloride in ethanol is pipetted into 24.270 mL of injection water, then 92 mg of calcium chloride dihydrate are added and the resulting solution is thoroughly mixed. 175 mg of cross-linked polyvinylpyrrolidone (Kollidon 30) are gradually poured into this solution, with constant mixing. Thereafter, the pH is changed with the addition of 2.5 μM 5M NaOH and the solution is stirred thoroughly. Finally, 450 mg of sodium hyaluronan having a molecular weight of 1.78 × 10 6 g / mol is gradually poured in, and the solution is thoroughly stirred again. The resulting viscous solution is dosed into suitable casings, for example in glass vials, in tubes or hypodermic syringes. Then it is sterilized with moist heat. The total concentration of polysaccharides in the gel is thus 2.5% by weight. The gel is intended for veterinary practice, for example, for the treatment of gums after removal of tartar, especially in dogs and cats, with regard to its pH, which is in the range of 7.4 +/- 0.4 , which corresponds to the pH of saliva, especially in dogs and cats. EXAMPLE 7

Gel with Hyaluronan, Octenidine Dihydrochloride and Carboxymethyl Cellulose 6 μΙ of 10% solution of octenidine dihydrochloride in ethanol is pipetted into 24.750 ml of injection water and the resulting solution is thoroughly mixed. 150 mg of carboxymethylcellulose and 100 mg of sodium hyaluronan having a molecular weight of 2.5 × 10 6 g / mol are gradually poured into this solution, with constant mixing, and the solution is thoroughly stirred. The resulting viscous solution is dosed into suitable casings, for example in glass vials, in tubes or hypodermic syringes. Then it is sterilized with moist heat. The total concentration of polysaccharides in the gel is thus 1% by weight. The gel is intended for the treatment of gingiva after removal of tartar, for the treatment or prevention of alveolar osteitis or for the treatment of other oral mucosal or skin lesions, and also in the case of a microbial infection. EXAMPLE 8

Hyaluronan, hydroxyethylcellulose, calcium chloride, octenidine dihydrochloride and BAC benzalkonium chloride gel

16 μΙ of 10% solution of octenidine dihydrochloride in ethanol is pipetted into 24.342 ml of injection water and the resulting solution is thoroughly mixed. 150 mg of hydroxyethylcellulose are gradually poured into this solution with constant mixing. Thereafter, 2.5 mg of calcium chloride dihydrate is added and the resulting solution is thoroughly mixed. Subsequently, 2.5 .mu.l benzalkonium chloride is added, the solution is thoroughly mixed and then the pH with the addition of 1.7 .mu.Ι 5M

NaOH converted. Finally, 450 mg of sodium hyaluronan having a molecular weight of 1.78 × 10 6 g / mol is gradually poured in, and the solution is thoroughly stirred again. The resulting viscous solution is dosed into suitable casings, for example in glass vials, in tubes or hypodermic syringes. The total concentration of polysaccharides in the gel is thus 2.5% by weight. The gel is intended for veterinary practice, for example, for the treatment of gums after removal of tartar, especially in dogs and cats, because of its pH, which is in the range of 7.4 +/- 0.4, which the pH of saliva just in dogs and cats. EXAMPLE 9

Gel with hyaluronan, octenidine dihydrochloride, calcium chloride, hydroxyethylcellulose and polyvinylpyrrolidone 30.4 μΙ of 10% solution of the octenidine dihydrochloride in ethanol is pipetted into 23.68 ml of injection water, then the pH is added with addition of 2.4 μΙ 5M NaOH and the resulting solution is thoroughly mixed. 200 mg of hydroxyethylcellulose and 750 mg of cross-linked polyvinylpyrrolidone (Kollidon 90F) are gradually poured into this solution with constant mixing. Further, 92 mg of calcium chloride is added and the resulting solution is thoroughly mixed. Finally, 250 mg of sodium hyaluronan having a molecular weight of 1.78 × 10 6 g / mol is gradually poured in, and the solution is thoroughly stirred again. The total concentration of polysaccharides in the gel is thus 4.8% by weight. EXAMPLE 10

Gel with Hyaluronan, Octenidine Dihydrochloride, Calcium Chloride, Alginate and Polyvinylpyrrolidone 30.4 μΙ of 10% solution of octenidine dihydrochloride in ethanol is pipetted into 23.69 ml of injection water and the resulting solution thoroughly mixed. Thereafter, the pH is changed with the addition of 2 μΙ 5M NaOH and the solution is thoroughly mixed. 250 mg of alginate and 700 mg of cross-linked polyvinylpyrrolidone (Kollidon 90F) are gradually poured into this solution with constant mixing. After thorough stirring of the solution, 92 mg of calcium chloride dihydrate is added and the resulting solution is thoroughly mixed again. Finally, 250 mg of sodium hyaluronan with a molecular weight of 2.5 × 10 6 g / mol are gradually poured in and the solution is stirred thoroughly again. The total concentration of polysaccharides in the gel is thus 4.8% by weight.

Claims (12)

claims A hyaluronan-octenidine dihydrochloride-based dental preparation characterized by containing physiologically acceptable salts of hyaluronanic acid and octenidine dihydrochloride in a weight ratio of 100: 1 to 2000: 1, said agent being in the form of lyophilisate or gel. 2. A dental agent according to claim 1, characterized in that the physiologically acceptable salt of hyaluronanic acid is selected from a group containing alkali metal or alkaline earth ions, preferably Na +, K +, Ca 2+ or Mg 2+. 3. A dental agent according to claim 1 or 2, characterized in that the molecular weight of the physiologically acceptable salt of hyaluronanic acid in the range between 2 x 105 and 2.5 x 106 g / mol. 4. Dental agent according to one of the preceding claims 1 to 3, characterized in that the molecular weight of the physiologically acceptable salt of hyaluronanic acid in the range between 1 x 106 and 2.5 x 106 g / mol. 5. Dental agent according to one of the preceding claims 1 to 4, characterized in that it contains physiologically acceptable salt of hyaluronanic acid and octenidine dihydrochloride in a weight ratio of 400: 1 to 800: 1, preferably 500: 1. 6. A dental agent according to any one of the preceding claims 1 to 5, characterized in that it further contains at least one auxiliary polysaccharide selected from a group comprising carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylmethylcellulose, alginate or polyvinylpyrrolidone and / or at least one physiological acceptable inorganic salt. A dental composition according to claim 6, characterized in that the weight ratio of the physiologically acceptable salt of the hyaluronic acid and at least one auxiliary sac char is in the range of 80:20 to 20:80, preferably in the range of 75:25 to 40:60. A dental composition according to claim 6, characterized in that the physiologically acceptable inorganic salt is calcium chloride. The dental agent according to claim 8, characterized in that the molar ratio of the carboxyl groups of hyaluronan and the calcium ions is in the range of 1: 1 to 1: 0.1. 10. A dental agent according to claim 9, characterized in that the molar ratio of the carboxyl groups of hyaluronan and calcium ions is preferably in the range of 1: 0.4. 11. A dental agent according to any one of the preceding claims 1 to 10, characterized in that it is in the form of formed from lyophilizate tampon. 12. A dental agent according to any one of the preceding claims 1 to 10, characterized in that the total concentration of polysaccharides in the gel in the range of 1 to 5 wt.%, Preferably in the range of 4 to 5 wt.%.