CN106822988A - Alginate fibre functional dressing and its application, alginate fibre functional dressing patch - Google Patents
Alginate fibre functional dressing and its application, alginate fibre functional dressing patch Download PDFInfo
- Publication number
- CN106822988A CN106822988A CN201710066389.3A CN201710066389A CN106822988A CN 106822988 A CN106822988 A CN 106822988A CN 201710066389 A CN201710066389 A CN 201710066389A CN 106822988 A CN106822988 A CN 106822988A
- Authority
- CN
- China
- Prior art keywords
- alginate fibre
- fibre functional
- functional dressing
- dressing
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention provides a kind of alginate fibre functional dressing and its application, alginate fibre functional dressing patch, it is related to field of medical materials.The raw material of the alginate fibre functional dressing includes by mass percentage：Carrageenan oligosaccharide 0.5~2%, brown alga oligose 1.5~3%, seeweed polyphenol 0.5~1.5%, OPC 0.5~2.5%, sodium chloride 0.05~0.2%, Carbomer 0.5~1.5%；PH conditioning agents 0.01~0.1%, surgical appliance adhesive 0.5~2%, moisturizing NMF 0.01~0.2%, balance of water for injection.Alginate fibre functional dressing patch includes being adsorbed with the dressing surface layer of above-mentioned alginate fibre functional dressing.Alginate fibre functional dressing can effectively be repaired and damaged with healing skin, shorten the time of wound healing.Additionally, the application the invention provides above-mentioned alginate fibre functional dressing in reparation and healing skin are damaged.
Description
Technical field
The present invention relates to field of medical materials, in particular to a kind of alginate fibre functional dressing and its application, sea
Algae fiber functional dressing is pasted.
Background technology
Relevant research after the 1950's finds：Complete wound of the wound than blister ulceration of blister on wound
Healing rate is substantially accelerated.The zoopery discovery of Britain doctor G.D.WinterHinman in 1962, the wound of wet environment
Healing rate is faster 1 times than dryness healing, and doctor Winter confirms moistening and the wound dressing application institute with permeability first
In the wet environment of formation, epidermal cell can preferably multiply and divide a word with a hyphen at the end of a line, and this result of study and wet environment healing theory are sent out
Table exists《Nature》.1963Hinman draws same conclusion in the treatment of wounds of people first.Nineteen ninety Turner confirms wet
Profit environment can rapidly reduce the surface of a wound, increase granulation tissue and formed, and promote surface of a wound re-epithelialization.Johns Hopkins University of the U.S.
The report of Fonder etc. is pointed out to promote wound healing always treatment of wounds to obtain a mistaken ideas in a dry manner.Past 40
Year for many years in, substantial amounts of research report is proved, wet union theory is received by American-European countries's medical profession.
The sixties in 20th century, to have used the wound dressing of over half a century its design concept be to absorb sepage and the surface of a wound in forward position
The effect of isolation.Dressing material Quality Research is also mainly in terms of biologically inert, non-toxic and biocompatibility etc. to consider
, though traditional dry therapy can reduce the chance of trauma surface infestation, the surface of a wound of normal function is lost, it is directly exposed to drying
Air or the very strong dressing wrapping of hygroscopicity under, the substantial amounts of moisture evaporation of the surface of a wound or loss, it will make blood stasis and stagnant zone cell a large amount of
Dehydration, but because congestion and edema band microcirculation disorder, moisture can not be supplemented in time, damaged tissues accelerate death because of dehydration,
So that wound surface deepening, influences the absorbability of wound healing limited, Moist healing environment can improve microcirculation, reduce histocyte
Necrosis, protects the dynamic histocyte of the surface of a wound to greatest extent, the cell being at death's door gradually is recovered normal, while to fill
The early recovery of the swollen cell band of watery blood creates conditions.
In August, 2000, FDA Food and Drug Administration (FDA) points out in the new industry guide promulgated：Keep wound
Moist environment be standard wound processing method.Can mitigate pain with wet union theory on treatment wound face and avoid dry scab
Formed, and form the healing environment of moistening.The time of wound healing is substantially reduced, the hair of wound contamination and infection is reduced
It is raw, nursing staff's workload is reduced, significantly improve clinical economic benefit.
Medical science shaping and beauty progressively develops, such as facial laser, photon delicate skin, crystallite grinding, tartaric acid skin-active art etc., these
Need to nurse surface of a wound skin after Minimally Invasive Surgery, and existing dressing still uses dry therapy, dry therapy easily to deepen
The surface of a wound, while easily forming dry scab.
The content of the invention
It is an object of the invention to provide a kind of alginate fibre functional dressing, it can effectively repair and be damaged with healing skin
Wound, shortens the time of wound healing, reduces the generation of wound contamination and infection, reduces the generation of scar.
Another object of the present invention is to provide a kind of alginate fibre function with above-mentioned alginate fibre functional dressing
Property dressing patch.
A further object of the present invention is to provide above-mentioned alginate fibre functional dressing in reparation and healing skin are damaged
Application.
The present invention is solved its technical problem and is realized using following technical scheme.
A kind of alginate fibre functional dressing, its raw material includes by mass percentage：
Preferably, in the preferred embodiment, the raw material of above-mentioned alginate fibre functional dressing presses quality percentage
Number meter includes：
Preferably, in the preferred embodiment, the PH conditioning agents of above-mentioned alginate fibre functional dressing include lemon
At least one in lemon acid, phosphoric acid, sodium phosphate and sodium citrate.
Preferably, in the preferred embodiment, the surgical appliance adhesive of above-mentioned alginate fibre functional dressing includes
At least one in sodium carboxymethylcellulose and a-cyanoacrylate
Preferably, in the preferred embodiment, the moisturizing NMF of above-mentioned alginate fibre functional dressing is three
Monoethanolamine or glycerine.
Preferably, in the preferred embodiment, the raw material of above-mentioned alginate fibre functional dressing presses quality percentage
Number meter also includes antiseptic 0.04~0.2%, and antiseptic includes at least one in biological peptide, chitosan oligosaccharide and tridecanoic peptide.
Preferably, in the preferred embodiment, the raw material of above-mentioned alginate fibre functional dressing presses quality percentage
Number meter also includes arabo-ascorbic acid 0.2~0.3%.
A kind of alginate fibre functional dressing patch, it includes dressing surface layer, and uniform adsorption has above-mentioned marine alga on dressing surface layer
Fiber functional dressing.
Preferably, in the preferred embodiment, the material of the dressing surface layer of above-mentioned alginate fibre functional dressing patch
Material is selected from any one in non-woven fabrics, biological fibrous material, pectin fiber cloth, cotton and silk.
Application of the above-mentioned alginate fibre functional dressing in reparation and healing skin are damaged.
Compared with prior art, the beneficial effects of the invention are as follows：OK a karaoke club in the raw material of the alginate fibre functional dressing
Glue oligosaccharides also has blood coagulation resisting function, the wound healing of impaired skin can be helped, while carrageenan oligosaccharide has to radiation injury
Obvious protective action, and with the activity of very strong removing ultra-oxygen anion free radical and hydroxy radical, and have
Reducing power, and brown alga oligose, seeweed polyphenol and OPC all have an antioxidation activity, carrageenan oligosaccharide and brown alga oligose,
Seeweed polyphenol and OPC cooperate, and strengthen the ability of antioxidation activity, and then can play maintenance to damaged skin
Effect, additionally, brown alga oligose, seeweed polyphenol, OPC and sodium chloride also have bacteriostatic activity, is prevented from impaired skin and receives
To the infringement of bacterium and fungi, the impaired skin of protection, additionally, the PH conditioning agents in raw material can adjust alginate fibre functional dressing
The pH value of material and skin, makes skin keep optimum state, and surgical appliance adhesive can help impaired skin wound healing, and moisturizing is protected
Humectant can keep skin moisture, and then keep the moist environment of wound.Carbomer can be by above-mentioned raw materials gel and thickening, just
Fitted with dressing surface layer in marine alga dressing.Can mitigate pain with wet union theory on treatment wound face and avoid dry scab from being formed,
And form the healing environment of moistening.The time of wound healing is substantially reduced, the generation of wound contamination and infection is reduced, reduced
Nursing staff's workload, significantly improves clinical economic benefit.The raw material selected in the embodiment of the present invention is safety non-toxic
The material of side effect, it is safer.Dressing surface layer is soaked in above-mentioned alginate fibre functional dressing, it is then that dressing surface layer is straight
Connect and act on impaired skin, impaired skin can be played a part of to repair and be healed.The present invention is controlled with wet union theory
Treatment trauma face can mitigate pain and avoid dry scab from being formed, and form the healing environment of moistening.Substantially reduce wound healing when
Between, the generation of wound contamination and infection is reduced, nursing staff's workload is reduced, significantly improve clinical economic benefit.
Specific embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below will be in the embodiment of the present invention
Technical scheme be clearly and completely described.Unreceipted actual conditions person, builds according to normal condition or manufacturer in embodiment
The condition of view is carried out.Agents useful for same or the unreceipted production firm person of instrument, are the conventional product that can be obtained by commercially available purchase
Product.
Below to a kind of alginate fibre functional dressing of the embodiment of the present invention and its application, a kind of alginate fibre feature
Dressing patch is specifically described.
A kind of alginate fibre functional dressing, its raw material includes by mass percentage：
Preferably, above-mentioned raw materials include by mass percentage：
The specific composition to above-mentioned raw materials is illustrated below：
Carrageenan oligosaccharide is main to be obtained by carragheen degraded, and for carragheen, carrageenan oligosaccharide molecular weight is smaller, molten
Solution property is preferable, stability and security all make moderate progress, while because the active group on strand fully exposes, its original work
Property is improved, or even generates new activity.
Carrageenan oligosaccharide can substantially mitigate the reduction of radiation-induced spleen nk cell activity, hematopoiesis function is suppressed,
The symptoms such as blood cell source reduction, improve body's immunity, there is obvious protective action to radiation injury.
Carrageenan oligosaccharide mainly damages protection and the aspect of hematopoietic function recovery two of Immune Organs of Body by enhanced rad
Play radiation resistance.Carrageenan oligose has the very strong activity for removing ultra-oxygen anion free radical and hydroxy radical simultaneously,
And with reducing power.Carrageenan oligosaccharide also has intracellular antioxidation activity, and it can protect cells from hydrogen peroxide
Damage.Additionally, carrageenan oligosaccharide also has blood coagulation resisting function：Carragheen has the anticoagulant active similar to heparin, undegraded
Carragheen and fibrin form insoluble compound, and the carrageenan oligosaccharide degraded is soluble with fibrin generation multiple
Compound, and its toxicity is obviously reduced than undegraded carragheen.
The effect that brown alga oligose has anti-inflammatory, regulation immunity of organism activity, promotes cell growth and Green Tea Extract oxidation,
It is pure-natural marine living-things preparation.Seeweed polyphenol has antioxidation activity and bacteriostatic activity.
OPC can eliminate the oedema that postoperative skin wound is brought, and OPC not only helps collagen fabric shape
Into cross-linked structure, and can help recover the infringement of the excessive crosslinking caused by injured and free radical.Anthocyanidin is also protected
Human body promotes to cure psoriasis and senile plaque from sun damages.OPC plays multiple action in skin care item, such as anti-ageing
Always, uvioresistant, radioresistance, brighten, moisturizing etc., have functions that uniqueness to the skin aging that many factors are caused.
Sodium chloride concentration can kill bacterium and fungi higher than the physiological concentration of people by osmotic pressure.Colonize in human body
The bacterium on skin trauma surface, its cytoplasm concentration is suitable with Human Physiology concentration, and sodium chloride concentration is dense higher than bacterial cytoplasm
Degree, can be used to kill bacterium.Additionally, sodium chloride can increase the viscosity effect of cosmetic formulations system, it is possible to reduce formula is former
Material application amount, reduces cost.
Carbomer is the very important rheology control agent of a class, and the Carbomer after neutralization is outstanding gel-type vehicle, there is increasing
The important uses such as thick, suspension, good stability is widely used in emulsion, cream, gel.The addition of Carbomer can will be above-mentioned
Raw material gel, thickening, make alginate fibre functional dressing be fitted with skin or dressing surface layer.
PH conditioning agents are used to adjust the PH and skin PH of the alginate fibre functional dressing, skin is in best repair
State.PH conditioning agents include at least one in citric acid, phosphoric acid, sodium phosphate and sodium citrate.
Surgical appliance adhesive is used to bond damaged skin, helps skin healing, and in the present embodiment, surgical appliance adhesive is selected from carboxylic first
At least one in base sodium cellulosate and a-cyanoacrylate.Sodium carboxymethylcellulose can be as thickener, while conduct
Pharmaceutical carrier, when damaged skin is bonded, skin is penetrated into by the active ingredient of alginate fibre functional dressing, helps impaired skin
Repair and heal.And a-cyanoacrylate can not only bond impaired skin, also with certain antibacterial action, it is to avoid art
Suture rejection afterwards.Thus there is the advantages of infection rate is low, and postoperative scar is small in terms of skin contusion treatment.
Moisturizing NMF can play a part of moisturizing and lubrication to damaged skin, while skin is repaired, keep flesh
Skin moisture.Moisturizing NMF is triethanolamine or glycerine in the present embodiment.
Additionally, raw material also includes antiseptic 0.04~0.2% and arabo-ascorbic acid 0.2~0.3% by mass percentage.
Specifically, antiseptic can effectively prevent damaged skin from being infected by bacterium and fungi.Antiseptic includes biological peptide, chitosan oligosaccharide
With at least one in tridecanoic peptide.The oxidation resistance of arabo-ascorbic acid considerably beyond vitamin C, the different Vitamin C of human intake
Acid, can be transformed into vitamin C, and then have white-skinned face function to human skin in vivo.The addition of arabo-ascorbic acid can be improved
The oxidation resistance of alginate fibre functional dressing, so that alginate fibre functional dressing can be applied to solar dermatitis,
And the skin injury caused by excessively sunburn is improved significantly and repair such that it is able to light spot, nti-freckle.
Hold above-mentioned, carrageenan oligosaccharide, brown alga oligose and seeweed polyphenol being capable of Green Tea Extract oxidation, anti-inflammatory, raising cutin
Cell growth；Brown alga oligose, seeweed polyphenol, sodium chloride and antiseptic can effectively suppress bacterium and fungi, the impaired flesh of protection
Skin, additionally, PH conditioning agents, surgical appliance adhesive and moisturizing NMF can help skin to recover optimal pH, while entering to skin
Row moisturizing lubricates, and Carbomer can carry out gel, thickening to above-mentioned raw materials.Can be with shape in wound surface after the mixing of these supplementary materials
The injury repair beneficial to barrier damaged skin with mucous membrane and nursing into protective layer.
Carrageenan oligosaccharide in the raw material of the alginate fibre functional dressing also has blood coagulation resisting function, can help be damaged
The wound healing of skin.Carrageenan oligosaccharide has obvious protective action to radiation injury simultaneously, and super with very strong removing
The activity of oxygen anion free radical and hydroxy radical, and with reducing power, and brown alga oligose, seeweed polyphenol and former cyanine
Element all has antioxidation activity, and carrageenan oligosaccharide cooperates with brown alga oligose, seeweed polyphenol and OPC, strengthens antioxygen
Change the ability of activity, and then maintenance effect can be played to damaged skin.Additionally, brown alga oligose, seeweed polyphenol, OPC and
Sodium chloride also has bacteriostatic activity, is prevented from impaired skin and is damaged by bacterium and fungi, the impaired skin of protection.In raw material
PH conditioning agents can adjust the pH value of alginate fibre functional dressing and skin, skin is kept optimum state, and skin is viscous
Mixture coordinates with Carbomer can make alginate fibre functional dressing in glue state, while impaired skin wound can be helped to heal
Close, moisturizing NMF can keep skin moisture, and then keep the moist environment of wound.With wet union theory on treatment wound
Face can mitigate pain and avoid dry scab from being formed, and form the healing environment of moistening.The time of wound healing is substantially reduced, is reduced
Wound contamination and the generation of infection, reduce nursing staff's workload, significantly improve clinical economic benefit.The present invention is implemented
The raw material selected in example is the material of safe without toxic side effect, safer.The present invention uses wet union theory on treatment wound
Face can mitigate pain and avoid dry scab from being formed, and form the healing environment of moistening.The time of wound healing is substantially reduced, is reduced
Wound contamination and the generation of infection, reduce nursing staff's workload, significantly improve clinical economic benefit.
It should be noted that the raw material selected in the embodiment of the present invention is non-animal source composition, can avoid former from animal sources
Expect produce allergy, poor compatibility, rejection high the problems such as, the embodiment of the present invention select materials safety, have no side effect, example
Such as, carrageenan oligosaccharide is obtained by carragheen degraded, and brown alga oligose, seeweed polyphenol and OPC are carried from plant
Take, the compatibility of the raw material human body surface of a wound of plant source is higher, and rejection is low, and then is not easy to cause the phenomenon of allergy, the present invention
Alginate fibre functional dressing cannot be only used for external application obtained in embodiment, can also take orally.The alginate fibre functional dressing
Preparation method it is simple, comprise the following steps that：
S1, the surgical appliance adhesive of formula ratio is dissolved in water for injection, is made solution, adjust pH value with PH conditioning agents, extremely
5.5-7.5,3~4h of placement, then the prepared glue of used membrane filtration is standby；
S2, the carrageenan oligosaccharide of formula ratio, brown alga oligose, seeweed polyphenol, OPC and moisturizing NMF are dissolved in it is few
Amount water for injection in, plus formula ratio sodium chloride, be subsequently adding the 0.5% of volume injection-use activated carbon dissolving circulation
30min is obtained and repairs liquid；
S3, by the reparation liquid of S2 be filtered until clear after mix with the glue in S1, fill penetrate water use regulation carrageenan oligosaccharide,
The content of brown alga oligose, seeweed polyphenol, OPC, moisturizing NMF, surgical appliance adhesive and PH conditioning agents in formula range,
And adjust isotonic with sodium chloride, alginate fibre functional dressing is obtained；
S4, the alginate fibre functional dressing in S3 is sterilized.
The preparation method of the alginate fibre functional dressing that the present embodiment is provided is simple, and operation is easy, easily realizes.
Additionally, the embodiment of the invention provides a kind of alginate fibre functional dressing patch, it includes dressing surface layer, dressing face
Uniform adsorption has above-mentioned alginate fibre functional dressing on layer.The material of dressing surface layer may be selected from non-woven fabrics, biological fibrous material,
Any one in pectin fiber cloth, cotton and silk.
Wherein, biological fibrous material is the corpus fibrosum for having acetobacter xylinum spontaneous fermentation to be made.With the dermatoid function of class,
Energy oxygen flow isolation bacterium, can be used in the coating of burn and scald, be the nanometer for deriving out via rigorous Fermentation Engineering
Level organic fiber.
The characteristic of biological fibrous material is as follows：The natural fiber that organic fiber is made is most small organic fibre in nature
Dimension, fibre diameter is about 0.05~0.08 micron, while 3D stereo staggered structures are presented, air can be allowed to pass through, soft to have simultaneously
There is excellent toughness.It has extremely strong water absorbing properties and extremely strong oil extraction dirt-removing power, no matter by any credit oil or iundustrial oil
Polluted, can be washed away in clear water easily, without cleaning agent, and itself there is the characteristic of non-sticky greasy dirt.Using biology
The facial mask quality that fibrous material is made is very soft, and elasticity is good, and toughness is strong, non-stimulated free from extraneous odour, is difficult growth bacterium, without glimmering
Stimulative substance, easily cleaning, is pure natural health environment-friendly articles for use.Because biological fibrous material has the characteristic do not repelled by human body,
Therefore, cardiovascular reparation is used as in medical field to be used with artificial skin.
Because Biofibre facial mask has superpower skin-friendly, while have that the cladding energy of wrinkle and Pi Qiu depths can be pasted into again
Power, therefore more general cloth surface of second order film more lifts surface application effect, and skin can be adjacent to, be not in the phenomenon that general facial mask comes off.
Preferably using biological fibrous material as dressing surface layer in the present embodiment.
In actual production and application, alginate fibre functional dressing patch can be cut into arbitrary shape, to fit
The surface of a wound of different shapes.Sacral shape, joint shape, facial mask shape, butterfly and teardrop shaped, zigzag.Alginate fibre functional dressing is pasted
Specification has multiple choices, for example：5g、10g、15g、20g、25g、30g、35g、50g.
The alginate fibre functional dressing patch that the present embodiment is provided is the non-sterile medical dressing of external application of single use, its
Superficial wound face is externally applied to be removed after 25-30 minutes, it is contemplated that use time within 24 hours, to facial laser, photon delicate skin,
Pigmentation and scar after the invasive surgeries such as crystallite grinding, tartaric acid skin-active art are formed, and can promote absorption of the skin to nutriment,
Shorten the course of disease and the human body superficial surface of a wound, dermatitis and eczema, solar dermatitis, allergic dermatitis, steroid dependent dermatitis etc. are made
Damage into barrier damaged skin and mucous membrane has the effect of reparation and nursing, according to《(office makes the 15th to medical apparatus classification rule
Number)》Article 6 and medical apparatus classification decision table carry out 6864 medical sanitary materials being judged under II class medicine equipment of classifying
Material and dressing.
Additionally, the embodiment of the present invention additionally provides above-mentioned alginate fibre functional dressing in reparation and healing skin are damaged
Application.Specifically, the alginate fibre functional dressing can be applied to the human body superficial surface of a wound, dermatitis and eczema, solar dermatitis,
Allergic dermatitis, steroid dependent dermatitis, bedsore, diabetes, abscess, ulcer etc., to barrier damaged skin and the damage of mucous membrane
Wound has the effect repaired with nursing；After the invasive surgeries such as facial laser operation, photon delicate skin, crystallite grinding, tartaric acid skin-active art
The scytitis later stage Secondary cases skin damaged, such as erythema, pigmentation spots, drying such as pigmentation and scar formation, light moderate acne
Furfur, small scar, swelling, thin crust, with it is anti-oxidant, remove free radical, improve it is allergic, beautification skin, prevented
Absorption of the skin injury, promotion skin subsisted caused by shining to nutriment, while being conducive to keeping the effect of skin elasticity.
Formula of the invention is illustrated with reference to specific embodiment.
Embodiment one：
The raw material dosage of alginate fibre functional dressing is as follows：Carrageenan oligosaccharide 1%, brown alga oligose 1.8%, seeweed polyphenol
0.6%th, OPC 1%, sodium chloride 0.07%, Carbomer 0.5%, PH conditioning agents 0.06%, surgical appliance adhesive 0.6%, profit
Skin NMF 0.2%, biological peptide 0.15%, water for injection add to 100%.Wherein, PH conditioning agents are citric acid；Surgical appliance adhesive
It is sodium carboxymethylcellulose；Moisturizing NMF is glycerine；Antiseptic is biological peptide.
The preparation method of alginate fibre functional dressing：Above-mentioned raw materials are dissolved in water for injection according to proportioning, are stirred
Uniformly.
The preparation method of alginate fibre functional dressing patch：The dressing surface layer that pectin fiber cloth material is made is soaked in this
In the alginate fibre functional dressing that embodiment is provided, make uniform adsorption alginate fibre functional dressing on dressing surface layer, make
Obtain alginate fibre functional dressing patch.
Embodiment two
The raw material dosage of alginate fibre functional dressing is as follows：Carrageenan oligosaccharide 1.5%, brown alga oligose 2.5%, marine alga are more
Phenol 0.5%, OPC 1.2%, sodium chloride 0.07%, Carbomer 1.5%, PH conditioning agents 0.05%, surgical appliance adhesive
1.3%th, moisturizing NMF 0.1%, antiseptic 0.04%, arabo-ascorbic acid 0.25%, water for injection add to 100%.Wherein：PH
Conditioning agent is citric acid；Surgical appliance adhesive is sodium carboxymethylcellulose；Moisturizing NMF is glycerine；Antiseptic is chitosan oligosaccharide.
The preparation method of alginate fibre functional dressing patch：In the present embodiment, the preparation of alginate fibre functional dressing patch
Method is identical with embodiment one, and difference is, in the present embodiment the dressing surface layer of alginate fibre functional dressing patch be by
What nonwoven cloth material was made.
Embodiment three
The raw material dosage of alginate fibre functional dressing is as follows：Carrageenan oligosaccharide 1.1%, brown alga oligose 2%, seeweed polyphenol
1%th, OPC 1.9%, sodium chloride 0.07%, Carbomer 1%, PH conditioning agents 0.04%, surgical appliance adhesive 0.5%, moisturizing
NMF 0.05%, antiseptic 0.19%, water for injection add to 100%.Wherein, PH conditioning agents are citric acid 0.02% and lemon
Sour sodium 0.02%；Surgical appliance adhesive is sodium carboxymethylcellulose；Moisturizing NMF is glycerine；Antiseptic is tridecanoic peptide.
The preparation method of alginate fibre functional dressing patch：In the present embodiment, the preparation of alginate fibre functional dressing patch
Method is identical with embodiment one, and difference is, in the present embodiment the dressing surface layer of alginate fibre functional dressing patch be by
What biological fibrous material was made.
Example IV
The raw material dosage of alginate fibre functional dressing is as follows：Carrageenan oligosaccharide 0.5%, brown alga oligose 1.5%, marine alga are more
Phenol 1.5%, OPC 0.5%, sodium chloride 0.05%, Carbomer 0.7%, PH conditioning agents 0.01%, surgical appliance adhesive 2%,
Moisturizing NMF 0.01%, antiseptic 0.2%, water for injection add to 100%.Wherein, PH conditioning agents are phosphoric acid；Surgical appliance adhesive
It is sodium carboxymethylcellulose 1% and a-cyanoacrylate 1%；Moisturizing NMF is glycerine；Antiseptic is biological peptide 0.1%
With tridecanoic peptide 0.1%.
The preparation method of alginate fibre functional dressing patch：In the present embodiment, the preparation of alginate fibre functional dressing patch
Method is identical with embodiment one, and difference is, in the present embodiment the dressing surface layer of alginate fibre functional dressing patch be by
Silk material is made.
Embodiment five
The raw material dosage of alginate fibre functional dressing is as follows：Carrageenan oligosaccharide 2%, brown alga oligose 3%, seeweed polyphenol
1%th, OPC 2.5%, sodium chloride 0.2%, Carbomer 0.8%, PH conditioning agents 0.1%, surgical appliance adhesive 1%, moisturizing are protected
Humectant 0.15%, antiseptic 0.15%, arabo-ascorbic acid 0.3%, water for injection add to 100%.Wherein, PH conditioning agents are lemon
Acid 0.05%, phosphoric acid 0.01%, sodium phosphate 0.02% and sodium citrate 0.02%；Surgical appliance adhesive is a-cyanoacrylate；
Moisturizing NMF is triethanolamine；Antiseptic is biological peptide 0.05%, chitosan oligosaccharide 0.05% and tridecanoic peptide 0.05%.
Embodiment six
The raw material dosage of alginate fibre functional dressing is as follows：Carrageenan oligosaccharide 1.2%, brown alga oligose 2%, seeweed polyphenol
0.8%th, OPC 2%, sodium chloride 0.1%, Carbomer 0.6%, PH conditioning agents 0.08%, surgical appliance adhesive 1.5%, moisturizing
NMF 0.1%, antiseptic 0.1%, arabo-ascorbic acid 0.2%, water for injection add to 100%.Wherein, PH conditioning agents are lemon
Acid 0.05%, phosphoric acid 0.01% and sodium citrate 0.02%；Surgical appliance adhesive is a-cyanoacrylate；Moisturizing NMF is
Triethanolamine；Antiseptic is biological peptide.
Next first the alginate fibre functional dressing in the present embodiment is detected and testing result such as table 1 is drawn：
The testing result of table 1.
Secondly the alginate fibre functional dressing patch provided in the present embodiment is illustrated：
1st, application method：External application.Cleaning illing skin, takes marine alga skin repair patch external application affected part, and light pressure non-woven fabrics makes it
It is adjacent to, each 25-30 minutes, once a day, continuous to use one week, second week is used 2-3 times, is within two weeks a course for the treatment of.
2nd, performance indications
2.1 outward appearances：The fiber facial mask of moistening or gluey shaping pad pasting.
2.2pH values：5.5-7.5.
2.3 heavy metals：60/1000000ths must not be crossed.
2.4 total plate counts：≤1000CFU/g
2.5 moulds：≤100CFU/g
2.6 Pseudomonas aeruginosas：Must not detect.
2.7 Acute systemic toxicities：Without Acute systemic toxicity.
2.8 stimulate：It is reactionless.
3 test methods
3.1 outward appearances
Take 3 to be estimated under normal illumination, 2.1 regulation should be met.
3.2pH values
Water in pad pasting or viscous fluid are extruded, according to (《Chinese Pharmacopoeia》Four general rules 0631 of version in 2015) examine in accordance with the law
Test, control range should meet 2.2 regulation.
3.3 heavy metals
According to (《Chinese Pharmacopoeia》The method of four general rules of version in 2015 0821 first) check in accordance with the law, arbitration law according to (《Middle traditional Chinese medicines
Allusion quotation》Four general rules 2321 of version in 2015) to check in accordance with the law, control range should meet 2.3 regulation.
3.4 total plate counts
According to (《Chinese Pharmacopoeia》Four general rules 1105 of version in 2015) check in accordance with the law, meet 2.4 regulation.
3.5 moulds
According to (《Chinese Pharmacopoeia》Four general rules 1105 of version in 2015) check in accordance with the law, meet 2.5 regulation.
3.6 Pseudomonas aeruginosas
According to (《Chinese Pharmacopoeia》Four general rules 1105 of version in 2015) check in accordance with the law, meet 2.6 regulation.
3.7 acute systemic toxicities
According to the ratio of 0.1g/mL, (72 ± 2) h is extracted under the conditions of (37 ± 1) DEG C, according to GB/T 16886.11-2011
Middle chapter 5 specifies test method, is tested using A.2 skin route of exposure, as a result should meet 2.7 requirement.
3.8 stimulate
According to the ratio of 0.1g/mL, (72 ± 2) h is extracted under the conditions of (37 ± 1) DEG C, according to GB/T 16886.10-2005
Middle Appendix B .2 regulations are tested, and as a result should meet 2.8 requirement.
4th, contrast test：With the comparing homogeny of like product
In sum, skin repair dressing and alginate fibre functional dressing are in performance requirement, desired use, user
Method, production technology are identical and skin repair dressing has been listed 2 years, and any clinical suspicious adverse events never occurred, and some face
Bed can be inquired using data in " middle National IP Network ".Can also be looked on official of State Food and Drug Administration data message
To the relevant information of many like products.The comparative illustration table of two products can be found in table 2.
The product comparative illustration table of table 2.
The contrast experiment to said two products illustrates below, but application not limited to this of the invention.
Application examples
Choose invasive surgery after, dermatitis and eczema, acne, allergic dermatitis patient totally 100,13~37 years old age, wherein；It is micro-
Wound postoperative patient 25, containing women 20, male 5；Dermatitis and eczema patient 40, containing women 30, male 10；Acne is suffered from
Person 15, containing women 8, male 7；Allergic dermatitis patient 20, containing women 15, male 5.To this 100 patients
Take following therapeutic scheme：Cleaning illing skin, takes alginate fibre functional dressing external application affected part, each 25-30 minutes, daily
Once, continuous to use one week, second week is used 2-3 times, is within two weeks a course for the treatment of.
The standard of curative effect evaluation includes：
(1) cure：Wound is wholly absent, and is produced without bacterium infection and scar；
(2) effectively：Wound is substantially eliminated, and without bacterium infection, scar is produced but of light color；
(3) it is invalid：Wound is without significant change.
Clinical practice experimental result is referring to table 3：
The clinical practice experimental result of the application alginate fibre functional dressing of table 3.
| The state of an illness | Total number of persons | Cure | Effectively | It is invalid | It is efficient |
| After invasive surgery | 25 people | 20 | 5 | 0 | 100% |
| Dermatitis and eczema | 40 people | 28 | 12 | 0 | 100% |
| Acne | 15 people | 13 | 2 | 0 | 100% |
| Allergic dermatitis | 20 people | 13 | 7 | 0 | 100% |
From upper table application experiment result, alginate fibre functional dressing provided in an embodiment of the present invention is directed to invasive surgery
Afterwards, the surface of a wound such as dermatitis and eczema, acne, allergic dermatitis skin has with significant curative effect.
Additionally, the curative effect to further illustrate alginate fibre functional dressing provided in an embodiment of the present invention, is also carried out
Substantial amounts of clinical comparison experiment, is illustrated by taking existing conventional skin repair dressing as an example below, but comparative illustration is not limited
In this.The specific composition and operation principle of the skin repair dressing can be found in above-mentioned table 2.
Control experiment example
Choose invasive surgery after, dermatitis and eczema, acne, allergic dermatitis patient totally 100,16~33 years old age, wherein；It is micro-
Wound postoperative patient 35, containing women 28, male 7；Dermatitis and eczema patient 28, containing women 20, male 8；Acne is suffered from
Person 25, containing women 8, male 17；Allergic dermatitis patient 12, containing women 6, male 6.To this 100 patients
Take following therapeutic scheme：Cleaning illing skin, takes skin repair dressing external application affected part, each 25-30 minutes, once a day,
Continuous to use one week, second week is used 2-3 times, is within two weeks a course for the treatment of.
The standard of curative effect evaluation includes：
(1) cure：Wound is wholly absent, and is produced without bacterium infection and scar；
(2) effectively：Wound is substantially eliminated, and without bacterium infection, scar is produced but of light color；
(3) it is invalid：Wound is without significant change.
Clinical practice experimental result is referring to table 4：
The clinical practice experimental result of the application skin repair dressing of table 4.
| The state of an illness | Total number of persons | Cure | Effectively | It is invalid | It is efficient |
| After invasive surgery | 35 people | 10 | 20 | 5 | 85.7% |
| Dermatitis and eczema | 28 people | 10 | 14 | 4 | 85.7% |
| Acne | 25 people | 15 | 3 | 7 | 72% |
| Allergic dermatitis | 12 people | 1 | 3 | 8 | 33.3% |
Through control experiment example as can be seen that alginate fibre functional dressing provided in an embodiment of the present invention is directed to invasive surgery
Afterwards, dermatitis and eczema, acne, allergic dermatitis have good therapeutic effect, and effective percentage reaches 100%.
Embodiments described above is a part of embodiment of the invention, rather than whole embodiments.Reality of the invention
The detailed description for applying example is not intended to limit the scope of claimed invention, but is merely representative of selected implementation of the invention
Example.Based on the embodiment in the present invention, what those of ordinary skill in the art were obtained under the premise of creative work is not made
Every other embodiment, belongs to the scope of protection of the invention.
Claims (10)
1. a kind of alginate fibre functional dressing, it is characterised in that its raw material includes by mass percentage：
2. alginate fibre functional dressing according to claim 1, it is characterised in that the raw material is by mass percentage
Including：
3. alginate fibre functional dressing according to claim 1, it is characterised in that the PH conditioning agents include lemon
At least one in acid, phosphoric acid, sodium phosphate and sodium citrate.
4. alginate fibre functional dressing according to claim 1, it is characterised in that the surgical appliance adhesive includes carboxylic first
At least one in base sodium cellulosate and a-cyanoacrylate.
5. alginate fibre functional dressing according to claim 1, it is characterised in that the moisturizing NMF is three ethanol
Amine or glycerine.
6. alginate fibre functional dressing according to claim 1, it is characterised in that the raw material is by mass percentage
Also include antiseptic 0.04~0.2%, the antiseptic includes at least one in biological peptide, chitosan oligosaccharide and tridecanoic peptide.
7. alginate fibre functional dressing according to claim 1, it is characterised in that the raw material is by mass percentage
Also include arabo-ascorbic acid 0.2~0.3%.
8. a kind of alginate fibre functional dressing is pasted, it is characterised in that it includes dressing surface layer, is uniformly inhaled on the dressing surface layer
With the alginate fibre functional dressing as described in any one of claim 1~7.
9. alginate fibre functional dressing according to claim 8 is pasted, it is characterised in that the material choosing of the dressing surface layer
Any one from non-woven fabrics, biological fibrous material, pectin fiber cloth, cotton and silk.
10. the alginate fibre functional dressing as described in any one of claim 1~7 in reparation and healing skin are damaged should
With.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710066389.3A CN106822988B (en) | 2017-02-08 | 2017-02-08 | Alginate fiber functional dressing and application thereof, and alginate fiber functional dressing patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710066389.3A CN106822988B (en) | 2017-02-08 | 2017-02-08 | Alginate fiber functional dressing and application thereof, and alginate fiber functional dressing patch |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106822988A true CN106822988A (en) | 2017-06-13 |
| CN106822988B CN106822988B (en) | 2019-12-31 |
Family
ID=59121406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710066389.3A Active CN106822988B (en) | 2017-02-08 | 2017-02-08 | Alginate fiber functional dressing and application thereof, and alginate fiber functional dressing patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106822988B (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108852900A (en) * | 2018-09-11 | 2018-11-23 | 吉林省蓝鼎陆和科技有限公司 | A kind of antibacterial facial mask and preparation method thereof containing tridecanoic peptide |
| CN108852944A (en) * | 2018-09-11 | 2018-11-23 | 吉林省蓝鼎陆和科技有限公司 | It is a kind of using OPC as tridecanoic peptide antibacterial repair latex of carrier and preparation method thereof |
| CN109106979A (en) * | 2018-09-11 | 2019-01-01 | 吉林省蓝鼎陆和科技有限公司 | A kind of tridecanoic peptide antiseptic dressing and preparation method thereof |
| CN109619163A (en) * | 2018-12-01 | 2019-04-16 | 浙江海洋大学 | A kind of production method of seeweed polyphenol-carrageenan oligosaccharide compound |
| CN110882176A (en) * | 2018-09-11 | 2020-03-17 | 吉林省蓝鼎陆和科技有限公司 | Tridecapeptide repairing and moisturizing mask taking OPC as carrier and manufacturing method thereof |
| CN110935056A (en) * | 2019-12-30 | 2020-03-31 | 山东星之诚生物科技有限公司 | Preparation method of alginate dressing with high hygroscopicity |
| CN111068097A (en) * | 2020-01-08 | 2020-04-28 | 河南亚都实业有限公司 | Sterilizing and anti-inflammatory wound repair dressing and preparation method thereof |
| CN111719221A (en) * | 2020-07-06 | 2020-09-29 | 温州大学 | Preparation method of high-breathability gauze special for diabetic foot |
| CN113318263A (en) * | 2021-08-02 | 2021-08-31 | 北京欣康研医药科技有限公司 | Antibacterial dressing and preparation method thereof |
| CN114832139A (en) * | 2022-05-17 | 2022-08-02 | 江西昂生生物科技有限公司 | Wound repair functional dressing and preparation method and application thereof |
| CN115607725A (en) * | 2021-12-31 | 2023-01-17 | 上海炫鑫医药科技有限公司 | Medical dressing with strong antibacterial property and preparation method thereof |
| CN117427201A (en) * | 2023-12-20 | 2024-01-23 | 辽宁帝东医药生物工程有限公司 | Antibacterial wound dressing capable of promoting healing |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279990A (en) * | 2008-05-05 | 2008-10-08 | 中国海洋大学 | Iota-carrageenan even oligosacchride monomer and preparation thereof |
| CN104622897A (en) * | 2015-03-04 | 2015-05-20 | 中英阿诺康（宁夏）生物科技有限公司 | Skin moisturizer for treating skin disease and preparation method of skin moisturizer |
| CN104994843A (en) * | 2013-02-13 | 2015-10-21 | 东亚制药株式会社 | Film-forming pharmaceutical composition for wound healing and method for preparing the same |
| CN105536042A (en) * | 2016-01-26 | 2016-05-04 | 依莱恩(上海)实业有限公司 | Hydrogel wound dressing and preparation method and application thereof |
| WO2016199905A1 (en) * | 2015-06-12 | 2016-12-15 | Ｊｆｅミネラル株式会社 | Therapeutic agent for skin wound or rough skin |
-
2017
- 2017-02-08 CN CN201710066389.3A patent/CN106822988B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279990A (en) * | 2008-05-05 | 2008-10-08 | 中国海洋大学 | Iota-carrageenan even oligosacchride monomer and preparation thereof |
| CN104994843A (en) * | 2013-02-13 | 2015-10-21 | 东亚制药株式会社 | Film-forming pharmaceutical composition for wound healing and method for preparing the same |
| CN104622897A (en) * | 2015-03-04 | 2015-05-20 | 中英阿诺康（宁夏）生物科技有限公司 | Skin moisturizer for treating skin disease and preparation method of skin moisturizer |
| WO2016199905A1 (en) * | 2015-06-12 | 2016-12-15 | Ｊｆｅミネラル株式会社 | Therapeutic agent for skin wound or rough skin |
| CN105536042A (en) * | 2016-01-26 | 2016-05-04 | 依莱恩(上海)实业有限公司 | Hydrogel wound dressing and preparation method and application thereof |
Non-Patent Citations (2)
| Title |
|---|
| 唐春红 主编: "《天然防腐剂与抗氧化剂》", 31 May 2010, 中国轻工业出版社 * |
| 邓开野 主编: "《天然药物概论》", 30 April 2008, 吉林科学技术出版社 * |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108852900B (en) * | 2018-09-11 | 2021-12-14 | 吉林省蓝鼎陆和科技有限公司 | Thirteen-peptide-containing antibacterial mask and preparation method thereof |
| CN108852944A (en) * | 2018-09-11 | 2018-11-23 | 吉林省蓝鼎陆和科技有限公司 | It is a kind of using OPC as tridecanoic peptide antibacterial repair latex of carrier and preparation method thereof |
| CN109106979A (en) * | 2018-09-11 | 2019-01-01 | 吉林省蓝鼎陆和科技有限公司 | A kind of tridecanoic peptide antiseptic dressing and preparation method thereof |
| CN110882176A (en) * | 2018-09-11 | 2020-03-17 | 吉林省蓝鼎陆和科技有限公司 | Tridecapeptide repairing and moisturizing mask taking OPC as carrier and manufacturing method thereof |
| CN108852900A (en) * | 2018-09-11 | 2018-11-23 | 吉林省蓝鼎陆和科技有限公司 | A kind of antibacterial facial mask and preparation method thereof containing tridecanoic peptide |
| CN109619163A (en) * | 2018-12-01 | 2019-04-16 | 浙江海洋大学 | A kind of production method of seeweed polyphenol-carrageenan oligosaccharide compound |
| CN110935056A (en) * | 2019-12-30 | 2020-03-31 | 山东星之诚生物科技有限公司 | Preparation method of alginate dressing with high hygroscopicity |
| CN111068097A (en) * | 2020-01-08 | 2020-04-28 | 河南亚都实业有限公司 | Sterilizing and anti-inflammatory wound repair dressing and preparation method thereof |
| CN111068097B (en) * | 2020-01-08 | 2021-12-07 | 优锐医药科技(上海)有限公司 | Sterilizing and anti-inflammatory wound repair dressing and preparation method thereof |
| CN111719221A (en) * | 2020-07-06 | 2020-09-29 | 温州大学 | Preparation method of high-breathability gauze special for diabetic foot |
| CN113318263A (en) * | 2021-08-02 | 2021-08-31 | 北京欣康研医药科技有限公司 | Antibacterial dressing and preparation method thereof |
| CN115607725A (en) * | 2021-12-31 | 2023-01-17 | 上海炫鑫医药科技有限公司 | Medical dressing with strong antibacterial property and preparation method thereof |
| CN114832139A (en) * | 2022-05-17 | 2022-08-02 | 江西昂生生物科技有限公司 | Wound repair functional dressing and preparation method and application thereof |
| CN117427201A (en) * | 2023-12-20 | 2024-01-23 | 辽宁帝东医药生物工程有限公司 | Antibacterial wound dressing capable of promoting healing |
| CN117427201B (en) * | 2023-12-20 | 2024-03-15 | 辽宁帝东医药生物工程有限公司 | Antibacterial wound dressing capable of promoting healing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106822988B (en) | 2019-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106822988A (en) | Alginate fibre functional dressing and its application, alginate fibre functional dressing patch | |
| CN108348577B (en) | Mussel mucin product and application thereof in inhibiting skin inflammation | |
| CN105107007B (en) | A kind of medical protective dressing of cation and preparation method thereof | |
| CN108136027A (en) | For the delivery system based on vaseline of active constituent | |
| CN107375905B (en) | Medical cold compress patch for repairing skin and preparation method thereof | |
| CN105168038B (en) | Golden flower flower clay mask and preparation method thereof | |
| CN110507845A (en) | Biological composite ventilating dressing and preparation method thereof | |
| CN108578747A (en) | A kind of gradient hyaluronic acid dressing and preparation method thereof | |
| CN111616992B (en) | Skin barrier repair compound, skin base fluid and preparation method thereof | |
| Khorasani et al. | The effects of Aloe Vera cream on split-thickness skin graft donor site management: a randomized, blinded, placebo-controlled study | |
| CN112842943A (en) | Itching-relieving moisturizing skin-repairing cream and preparation method thereof | |
| KR20100039532A (en) | Hydrogel composition for healing atopy and matrix patch for healing atopy using the hydrogel composition as a matrix | |
| JP2009269904A (en) | Herbal medicinal composition for curing external wound and bedsore and method of manufacturing medicine from the composition | |
| CN105616296A (en) | Populus tomentosa itch-stopping skin-protecting paste | |
| CN109432483A (en) | A kind of medical dressing and its preparation method and application accelerating wound healing | |
| RU2416425C1 (en) | Anti-decubitus oil | |
| CN111956562B (en) | Moisturizing liquid and mask moisturizing cotton batten | |
| CN111714681A (en) | Medical adhesive dressing and preparation method thereof | |
| CN107595819B (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof | |
| CN107982300B (en) | Spray and preparation method and application thereof | |
| CN112089827A (en) | Prebiotic-containing pharmaceutical composition for regulating female vaginal microecological balance, preparation and use thereof | |
| KR20210014515A (en) | Manufacturing method of hydrogel mask pack by using aloe and hydrogel mask pack by the same | |
| CN110585478A (en) | Hair-planting restoration liquid and preparation method thereof | |
| CN108355130A (en) | It is a kind of to treat psoriasic temperature sensitive type collagen composite antiphlogistic gel spray and preparation method thereof | |
| WO2023187632A1 (en) | Composition, application of the composition, cosmetic preparation hydrogel bio-mask in the form of a compress, method of manufacturing the preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |