CN114832139A - Wound repair functional dressing and preparation method and application thereof - Google Patents
Wound repair functional dressing and preparation method and application thereof Download PDFInfo
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- CN114832139A CN114832139A CN202210540495.1A CN202210540495A CN114832139A CN 114832139 A CN114832139 A CN 114832139A CN 202210540495 A CN202210540495 A CN 202210540495A CN 114832139 A CN114832139 A CN 114832139A
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- parts
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- functional dressing
- chitosan
- wound repair
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- 230000037314 wound repair Effects 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 52
- 206010052428 Wound Diseases 0.000 claims abstract description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 37
- 229920001661 Chitosan Polymers 0.000 claims abstract description 27
- 239000005313 bioactive glass Substances 0.000 claims abstract description 24
- 239000000853 adhesive Substances 0.000 claims abstract description 17
- 230000001070 adhesive effect Effects 0.000 claims abstract description 17
- RXGSAYBOEDPICZ-UHFFFAOYSA-N 2-[6-[[amino-(diaminomethylideneamino)methylidene]amino]hexyl]-1-(diaminomethylidene)guanidine Chemical compound NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)N RXGSAYBOEDPICZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 13
- 102000008186 Collagen Human genes 0.000 claims abstract description 13
- 108010035532 Collagen Proteins 0.000 claims abstract description 13
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 13
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 13
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940069521 aloe extract Drugs 0.000 claims abstract description 13
- 239000000648 calcium alginate Substances 0.000 claims abstract description 13
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 13
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 13
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 13
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- 239000012153 distilled water Substances 0.000 claims abstract description 13
- 239000000835 fiber Substances 0.000 claims abstract description 13
- 229920001542 oligosaccharide Polymers 0.000 claims abstract description 13
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 13
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960003500 triclosan Drugs 0.000 claims abstract description 12
- 230000029663 wound healing Effects 0.000 claims abstract description 8
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract description 7
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 24
- 239000000243 solution Substances 0.000 claims description 24
- 238000006243 chemical reaction Methods 0.000 claims description 20
- 238000001035 drying Methods 0.000 claims description 20
- 239000000047 product Substances 0.000 claims description 18
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 16
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 16
- 238000005406 washing Methods 0.000 claims description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 12
- 238000002156 mixing Methods 0.000 claims description 12
- 230000007935 neutral effect Effects 0.000 claims description 12
- 238000002791 soaking Methods 0.000 claims description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 10
- 239000011575 calcium Substances 0.000 claims description 10
- 229910052791 calcium Inorganic materials 0.000 claims description 10
- 230000006196 deacetylation Effects 0.000 claims description 10
- 238000003381 deacetylation reaction Methods 0.000 claims description 10
- 230000003544 deproteinization Effects 0.000 claims description 10
- 238000000746 purification Methods 0.000 claims description 10
- 229920002101 Chitin Polymers 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 239000004367 Lipase Substances 0.000 claims description 8
- 102000004882 Lipase Human genes 0.000 claims description 8
- 108090001060 Lipase Proteins 0.000 claims description 8
- 108090000526 Papain Proteins 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- 239000004365 Protease Substances 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 102000004142 Trypsin Human genes 0.000 claims description 8
- 108090000631 Trypsin Proteins 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 8
- 229940088598 enzyme Drugs 0.000 claims description 8
- 239000012065 filter cake Substances 0.000 claims description 8
- 230000001678 irradiating effect Effects 0.000 claims description 8
- 235000019421 lipase Nutrition 0.000 claims description 8
- 239000012046 mixed solvent Substances 0.000 claims description 8
- 235000006408 oxalic acid Nutrition 0.000 claims description 8
- 229940055729 papain Drugs 0.000 claims description 8
- 235000019834 papain Nutrition 0.000 claims description 8
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 238000009987 spinning Methods 0.000 claims description 8
- 239000012588 trypsin Substances 0.000 claims description 8
- 229960005188 collagen Drugs 0.000 claims description 7
- 229940072056 alginate Drugs 0.000 claims description 6
- -1 alginate oligosaccharide Chemical class 0.000 claims description 6
- 235000010443 alginic acid Nutrition 0.000 claims description 6
- 229920000615 alginic acid Polymers 0.000 claims description 6
- 208000025865 Ulcer Diseases 0.000 claims description 5
- IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 claims description 4
- 208000008960 Diabetic foot Diseases 0.000 claims description 4
- 229920000855 Fucoidan Polymers 0.000 claims description 4
- 241000238631 Hexapoda Species 0.000 claims description 4
- 241000234280 Liliaceae Species 0.000 claims description 4
- 208000004210 Pressure Ulcer Diseases 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- 238000010894 electron beam technology Methods 0.000 claims description 4
- 230000003628 erosive effect Effects 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 230000003301 hydrolyzing effect Effects 0.000 claims description 4
- 238000003760 magnetic stirring Methods 0.000 claims description 4
- 239000011259 mixed solution Substances 0.000 claims description 4
- 239000003002 pH adjusting agent Substances 0.000 claims description 4
- 239000002244 precipitate Substances 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 239000001509 sodium citrate Substances 0.000 claims description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 4
- 239000001488 sodium phosphate Substances 0.000 claims description 4
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 238000009210 therapy by ultrasound Methods 0.000 claims description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
- 231100000397 ulcer Toxicity 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 241001116389 Aloe Species 0.000 claims 1
- 235000011399 aloe vera Nutrition 0.000 claims 1
- 230000035876 healing Effects 0.000 abstract description 7
- 230000006378 damage Effects 0.000 abstract description 6
- 208000014674 injury Diseases 0.000 abstract description 6
- 241000199919 Phaeophyceae Species 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 229940127554 medical product Drugs 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 15
- 230000006872 improvement Effects 0.000 description 4
- 208000002847 Surgical Wound Diseases 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- HODBJNPCEPMORW-UHFFFAOYSA-N 2,4,5-trichloro-3-phenoxyphenol Chemical compound OC1=CC(Cl)=C(Cl)C(OC=2C=CC=CC=2)=C1Cl HODBJNPCEPMORW-UHFFFAOYSA-N 0.000 description 1
- 208000018380 Chemical injury Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 208000025962 Crush injury Diseases 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
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- 208000026935 allergic disease Diseases 0.000 description 1
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- 239000002131 composite material Substances 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
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- 230000007170 pathology Effects 0.000 description 1
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- 230000001172 regenerating effect Effects 0.000 description 1
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- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000010388 wound contraction Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to a wound repair functional dressing, a preparation method and application thereof, and belongs to the technical field of medical products. Comprises bioactive glass, calcium alginate fiber, chitosan, distilled water, pH regulator, aloe extract, triclosan, skin adhesive, polyvinyl alcohol, collagen, hexamethylene biguanide, brown algae oligosaccharide, radix Sophorae Flavescentis, cortex Phellodendri, carbomer, and triethanolamine. The invention provides a wound repair functional dressing, a preparation method and application thereof, which have a better function of absorbing seepage, form a moist microenvironment for wound healing on one hand, and are beneficial to jointly exerting the wound protection efficacy of a first functional dressing layer and a second functional dressing layer by setting the bottom of the dressing to be a porous structure on the other hand, thereby achieving the best healing effect on the wound, avoiding frequently uncovering the dressing for changing the dressing and reducing the risk of secondary injury of the wound.
Description
Technical Field
The invention relates to a wound repair functional dressing, a preparation method and application thereof, and belongs to the technical field of medical products.
Background
Wounds are skin defects caused by mechanical, electrical, thermal, chemical, etc. factors or formed by a medical or physiological allergy. According to macroscopic classification, wounds can be classified into open wounds (open wind) and closed wounds (close wind). Among them, closed wounds include contusions, hematomas and crush injuries. The treatment of such wounds is often different from open wounds and therefore not described in detail herein. The dressing described herein is primarily directed to the treatment of open wounds (wounds for short). Wounds may also be classified according to items such as pathology, wound site, cause of injury, or wound color. Generally, according to the healing time, the wound can be classified into an acute wound and a chronic wound; according to the color of the surface of the wound, the wound can be divided into red, yellow and black; according to the cause of the injury, it can be classified into mechanical or traumatic wounds, heat or chemical injury wounds, ulcerative wounds, and radioactive wounds.
Wound healing refers to a complex process of regenerative repair after a body tissue has suffered a wound. Taking the healing process of skin wounds as an example, the healing process comprises the stages of inflammatory reaction, wound contraction, granulation tissue proliferation, epidermis regeneration and the like in the early stage of the wound. The wound is in different healing stages, and the dressing requirements for nursing the wound are different. With the development and maturation of the wound healing theory, various new types of dressings emerge endlessly. However, the dressing made of a single material or the dressing made of a composite material cannot completely care complex wounds until the complex wounds are healed, and the combined care of a plurality of dressings is needed. Such frequent dressing changes to care for the wound often result in secondary injury or infection of the wound, sometimes even aggravating the infection. Therefore, the existing dressing often has a large surface defect in nursing complex wounds
Disclosure of Invention
In view of the above, the invention provides a wound repair functional dressing, a preparation method and an application thereof, which have a better function of absorbing seepage, and on one hand, a moist microenvironment for wound healing is formed, and on the other hand, the bottom of the dressing is provided with a porous structure, so that the dressing function of a first functional dressing layer and a second functional dressing layer can be exerted in a combined manner, the optimal healing effect on a wound is achieved, frequent dressing removal and dressing change are avoided, and the risk of secondary wound injury is reduced.
The invention provides a wound repair functional dressing and a preparation method and application thereof, wherein the wound repair functional dressing comprises 10-15 parts of bioactive glass, 25-40 parts of calcium alginate fiber, 15-25 parts of chitosan, 50-90 parts of distilled water, a pH regulator, 3-15 parts of an aloe extract, 1-10 parts of dichlorophenoxy chlorophenol, a skin adhesive, 2-8 parts of polyvinyl alcohol, 1-8 parts of collagen, 2-10 parts of hexamethylene biguanide, 15-25 parts of alginate oligosaccharide, 1-15 parts of radix sophorae flavescentis, 3-12 parts of cortex phellodendri, 5-15 parts of carbomer and 3-10 parts of triethanolamine.
The bioactive glass as a further improvement of the invention is prepared by adopting leaves of liliaceae plants as a biological template, and the bioactive glass has a nano-microporous structure.
The preparation method of the chitosan serving as a further improvement of the invention comprises the steps of calcium removal, deproteinization, purification and deacetylation
The further improvement of the invention comprises 10 parts of bioactive glass, 25 parts of calcium alginate fiber, 15 parts of chitosan, 50 parts of distilled water, a pH regulator, 3 parts of aloe extract, 1 part of triclosan, a skin adhesive, 2 parts of polyvinyl alcohol, 1 part of collagen, 2 parts of hexamethylene biguanide, 15 parts of brown algae oligosaccharide, 1 part of radix sophorae flavescentis, 3 parts of cortex phellodendri, 5 parts of carbomer and 3 parts of triethanolamine.
The further improvement of the invention comprises 15 parts of bioactive glass, 40 parts of calcium alginate fiber, 15-25 parts of chitosan, 50-90 parts of distilled water, pH regulator, 3-15 parts of aloe extract, 1-10 parts of triclosan, skin adhesive, 2-8 parts of polyvinyl alcohol, 1-8 parts of collagen, 2-10 parts of hexamethylene biguanide, 15-25 parts of alginate oligosaccharide, 1-15 parts of radix sophorae flavescentis, 3-12 parts of cortex phellodendri, 5-15 parts of carbomer and 3-10 parts of triethanolamine
The microporous structure of the bioactive glass is a hollow structure, the micropores are communicated with one another, and the pH value of the wound repair functional dressing is 7-9.
The pH adjusting agent includes at least one of citric acid, phosphoric acid, sodium phosphate, and sodium citrate, and the skin adhesive includes at least one of sodium carboxymethyl cellulose and alpha-cyanoacrylate.
The preparation method of the chitosan comprises the following steps:
1) calcium removal: pulverizing insect carapace, soaking and boiling in 10-20% diluted acid at 30-50 deg.C for 4-6 hr, filtering, washing filter cake with water for 1-3 times, and drying to obtain decalcified product A;
2) deproteinization: placing the decalcified product A, the complex enzyme and water in a reaction container, and controlling the pH of the reaction solution to be 7.5-8.5
Stirring and hydrolyzing for 2-3 hours at 40-55 ℃, filtering, washing and drying a filter cake to obtain a deproteinized product B for later use; the compound enzyme is a mixture of trypsin, papain and alkaline lipase, and the mass ratio of the trypsin to the papain to the alkaline lipase is 1: 1: 2;
3) and (3) purification: placing the deproteinized product B in a mixed solvent, adding neutral salt, stirring and dissolving at 60-80 ℃ for 1-3 hours, filtering, drying the filtrate under reduced pressure to remove the solvent, washing with water to remove the neutral salt, and drying to obtain the required chitin; the mixed solvent is a mixture of caproic acid, oxalic acid and pyridine, and the mass ratio of the caproic acid to the oxalic acid to the pyridine is 1: 0.8: 0.5;
4) deacetylation: and (3) adding the chitin obtained in the step (3) and a 15-20% NaOH aqueous solution into a quartz glass reaction container, placing the quartz glass reaction container under ultraviolet light for irradiating for 2-3 hours, simultaneously carrying out ultrasonic treatment, cooling to room temperature after the reaction is finished, centrifuging, washing the precipitate to be neutral, and drying for 24 hours at 50-60 ℃ to obtain the chitosan.
The invention further improves a preparation method of a wound repair functional dressing, which comprises the following steps
1) Mixing chitosan and polyvinyl alcohol, dissolving the mixture in 20-40% acetic acid water solution in volume ratio to obtain 10% spinning solution, heating in 90 ℃ water bath, stirring for 4-6 hours until the mixture is dissolved, standing and cooling for 2 hours, adding 5-30% calcium alginate fiber into the spinning solution, placing the mixed solution in a constant temperature oscillator at 70 ℃ for magnetic stirring uniformly, standing and defoaming to obtain shell solution;
2) mixing bioactive glass, distilled water, aloe extract, triclosan, collagen, hexamethylene biguanide, fucoidan oligosaccharide, radix sophorae flavescentis, cortex phellodendri, carbomer and triethanolamine at the temperature of 80-110 ℃, stirring, defoaming in vacuum, pouring into a mold, irradiating by adopting an electron beam of 100Gy/S for 8-10 minutes, soaking by adopting deionized water, changing water every 12 hours, repeatedly soaking for 3 times, adding a pH regulator and a skin adhesive, and mixing with a shell solution to obtain the wound repair functional dressing.
The functional dressing for further improving wound repair is suitable for burns, incised wounds, surgical wounds, cervical erosion, bedsores, sinuses, fatty liquefaction wounds, diabetic feet or various skin surface ulcers.
Advantageous effects
The invention provides a wound repair functional dressing, a preparation method and application thereof, which have a better function of absorbing seepage, form a moist microenvironment for wound healing on one hand, and are beneficial to jointly exerting the wound protection efficacy of a first functional dressing layer and a second functional dressing layer by setting the bottom of the dressing to be a porous structure on the other hand, thereby achieving the best healing effect on the wound, avoiding frequently uncovering the dressing for changing the dressing and reducing the risk of secondary injury of the wound.
Detailed Description
The preferred embodiments of the present invention will be described in detail below.
Example one
The invention provides a wound repair functional dressing and a preparation method and application thereof, wherein the wound repair functional dressing comprises 10 parts of bioactive glass, 25 parts of calcium alginate fibers, 15 parts of chitosan, 50 parts of distilled water, a pH regulator, 3 parts of aloe extract, 1 part of triclosan, a skin adhesive, 2 parts of polyvinyl alcohol, 1 part of collagen, 2 parts of hexamethylene biguanide, 15 parts of brown algae oligosaccharide, 1 part of radix sophorae flavescentis, 3 parts of cortex phellodendri, 5 parts of carbomer and 3 parts of triethanolamine.
The bioactive glass is prepared by adopting leaves of liliaceous plants as a biological template, and has a nano micropore structure
The preparation method of the chitosan comprises the steps of calcium removal, deproteinization, purification and deacetylation.
The microporous structure of the bioactive glass is a hollow structure, the micropores are communicated with one another, and the pH value of the wound repair functional dressing is 7-9.
The PH adjusting agent of the present invention comprises at least one of citric acid, phosphoric acid, sodium phosphate and sodium citrate, and the skin adhesive comprises at least one of sodium carboxymethyl cellulose and α -cyanoacrylate.
The preparation method of the chitosan comprises the following steps:
1) calcium removal: pulverizing insect carapace, soaking and boiling in 10-20% diluted acid at 30-50 deg.C for 4-6 hr, filtering, washing filter cake with water for 1-3 times, and drying to obtain decalcified product A;
2) deproteinization: placing the decalcified product A, the complex enzyme and water in a reaction container, and controlling the pH of the reaction solution to be 7.5-8.5
Stirring and hydrolyzing for 2-3 hours at 40-55 ℃, filtering, washing and drying a filter cake to obtain a deproteinized product B for later use; the compound enzyme is a mixture of trypsin, papain and alkaline lipase, and the mass ratio of the trypsin to the papain to the alkaline lipase is 1: 1: 2;
3) and (3) purification: placing the deproteinized product B in a mixed solvent, adding neutral salt, stirring and dissolving at 60-80 ℃ for 1-3 hours, filtering, drying the filtrate under reduced pressure to remove the solvent, washing with water to remove the neutral salt, and drying to obtain the required chitin; the mixed solvent is a mixture of caproic acid, oxalic acid and pyridine, and the mass ratio of the caproic acid to the oxalic acid to the pyridine is 1: 0.8: 0.5;
4) deacetylation: and (3) adding the chitin obtained in the step (3) and a 15-20% NaOH aqueous solution into a quartz glass reaction container, placing the quartz glass reaction container under ultraviolet light for irradiating for 2-3 hours, simultaneously carrying out ultrasonic treatment, cooling to room temperature after the reaction is finished, centrifuging, washing the precipitate to be neutral, and drying for 24 hours at 50-60 ℃ to obtain the chitosan.
The invention specifically comprises the following steps:
1) mixing chitosan and polyvinyl alcohol, dissolving the mixture in 20-40% acetic acid water solution in volume ratio to obtain 10% spinning solution, heating in 90 ℃ water bath, stirring for 4-6 hours until the mixture is dissolved, standing and cooling for 2 hours, adding 5-30% calcium alginate fiber into the spinning solution, placing the mixed solution in a constant temperature oscillator at 70 ℃ for magnetic stirring uniformly, standing and defoaming to obtain shell solution;
2) mixing bioactive glass, distilled water, aloe extract, triclosan, collagen, hexamethylene biguanide, fucoidan oligosaccharide, radix sophorae flavescentis, cortex phellodendri, carbomer and triethanolamine at the temperature of 80-110 ℃, stirring, defoaming in vacuum, pouring into a mold, irradiating by adopting an electron beam of 100Gy/S for 8-10 minutes, soaking by adopting deionized water, changing water every 12 hours, repeatedly soaking for 3 times, adding a pH regulator and a skin adhesive, and mixing with a shell solution to obtain the wound repair functional dressing.
The wound repair functional dressing is suitable for burns, incised wounds, surgical wounds, cervical erosion, bedsores, sinus wounds, fatty liquefaction wounds, diabetic feet or various skin surface ulcers.
Example two
The invention provides a wound repair functional dressing and a preparation method and application thereof, wherein the wound repair functional dressing comprises 15 parts of bioactive glass, 40 parts of calcium alginate fibers, 15-25 parts of chitosan, 50-90 parts of distilled water, a pH regulator, 3-15 parts of an aloe extract, 1-10 parts of triclosan, a skin adhesive, 2-8 parts of polyvinyl alcohol, 1-8 parts of collagen, 2-10 parts of hexamethylene biguanide, 15-25 parts of alginate oligosaccharides, 1-15 parts of radix sophorae flavescentis, 3-12 parts of cortex phellodendri, 5-15 parts of carbomer and 3-10 parts of triethanolamine.
The bioactive glass is prepared by adopting leaves of liliaceous plants as a biological template, and has a nano micropore structure
The preparation method of the chitosan comprises the steps of calcium removal, deproteinization, purification and deacetylation.
The microporous structure of the bioactive glass is a hollow structure, the micropores are communicated with one another, and the pH value of the wound repair functional dressing is 7-9.
The PH adjusting agent of the present invention comprises at least one of citric acid, phosphoric acid, sodium phosphate and sodium citrate, and the skin adhesive comprises at least one of sodium carboxymethyl cellulose and α -cyanoacrylate.
The preparation method of the chitosan comprises the following steps:
1) calcium removal: pulverizing insect carapace, soaking and boiling in 10-20% diluted acid at 30-50 deg.C for 4-6 hr, filtering, washing filter cake with water for 1-3 times, and drying to obtain decalcified product A;
2) deproteinization: placing the decalcified product A, the complex enzyme and water in a reaction container, and controlling the pH of the reaction solution to be 7.5-8.5
Stirring and hydrolyzing for 2-3 hours at 40-55 ℃, filtering, washing and drying a filter cake to obtain a deproteinized product B for later use; the compound enzyme is a mixture of trypsin, papain and alkaline lipase, and the mass ratio of the trypsin to the papain to the alkaline lipase is 1: 1: 2;
3) and (3) purification: placing the deproteinized product B in a mixed solvent, adding neutral salt, stirring and dissolving at 60-80 ℃ for 1-3 hours, filtering, drying the filtrate under reduced pressure to remove the solvent, washing with water to remove the neutral salt, and drying to obtain the required chitin; the mixed solvent is a mixture of caproic acid, oxalic acid and pyridine, and the mass ratio of the caproic acid to the oxalic acid to the pyridine is 1: 0.8: 0.5;
4) deacetylation: and (3) adding the chitin obtained in the step (3) and a 15-20% NaOH aqueous solution into a quartz glass reaction container, placing the quartz glass reaction container under ultraviolet light for irradiating for 2-3 hours, simultaneously carrying out ultrasonic treatment, cooling to room temperature after the reaction is finished, centrifuging, washing the precipitate to be neutral, and drying for 24 hours at 50-60 ℃ to obtain the chitosan.
The invention specifically comprises the following steps:
1) mixing chitosan and polyvinyl alcohol, dissolving the mixture in 20-40% acetic acid water solution in volume ratio to obtain 10% spinning solution, heating in 90 ℃ water bath, stirring for 4-6 hours until the mixture is dissolved, standing and cooling for 2 hours, adding 5-30% calcium alginate fiber into the spinning solution, placing the mixed solution in a constant temperature oscillator at 70 ℃ for magnetic stirring uniformly, standing and defoaming to obtain shell solution;
2) mixing bioactive glass, distilled water, aloe extract, triclosan, collagen, hexamethylene biguanide, fucoidan oligosaccharide, radix sophorae flavescentis, cortex phellodendri, carbomer and triethanolamine at the temperature of 80-110 ℃, stirring, defoaming in vacuum, pouring into a mold, irradiating by adopting an electron beam of 100Gy/S for 8-10 minutes, soaking by adopting deionized water, changing water every 12 hours, repeatedly soaking for 3 times, adding a pH regulator and a skin adhesive, and mixing with a shell solution to obtain the wound repair functional dressing.
The wound repair functional dressing is suitable for burns, incised wounds, surgical wounds, cervical erosion, bedsores, sinus wounds, fatty liquefaction wounds, diabetic feet or various skin surface ulcers.
The present invention and its embodiments have been described above, but the description is not limitative, and the actual structure is not limited thereto. In summary, those skilled in the art should appreciate that they can readily use the disclosed conception and specific embodiments as a basis for designing or modifying other structures for carrying out the same purposes of the present invention without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (8)
1. A wound repair functional dressing is characterized in that: the skin care product comprises 10-15 parts of bioactive glass, 25-40 parts of calcium alginate fiber, 15-25 parts of chitosan, 50-90 parts of distilled water, a pH regulator, 3-15 parts of aloe extract, 1-10 parts of triclosan, a skin adhesive, 2-8 parts of polyvinyl alcohol, 1-8 parts of collagen, 2-10 parts of hexamethylene biguanide, 15-25 parts of alginate oligosaccharide, 1-15 parts of radix sophorae flavescentis, 3-12 parts of cortex phellodendri, 5-15 parts of carbomer and 3-10 parts of triethanolamine;
the bioactive glass is prepared by adopting leaves of a liliaceae plant as a biological template, and has a nano micropore structure;
the preparation method of the chitosan comprises the steps of calcium removal, deproteinization, purification and deacetylation.
2. A wound repair functional dressing according to claim 1, wherein: the aloe gel is characterized by comprising 10 parts of bioactive glass, 25 parts of calcium alginate fiber, 15 parts of chitosan, 50 parts of distilled water, a pH regulator, 3 parts of aloe extract, 1 part of triclosan, a skin adhesive, 2 parts of polyvinyl alcohol, 1 part of collagen, 2 parts of hexamethylene biguanide, 15 parts of alginate oligosaccharide, 1 part of radix sophorae flavescentis, 3 parts of cortex phellodendri, 5 parts of carbomer and 3 parts of triethanolamine;
the bioactive glass is prepared by adopting leaves of a liliaceae plant as a biological template, and has a nano micropore structure;
the preparation method of the chitosan comprises the steps of calcium removal, deproteinization, purification and deacetylation.
3. A wound repair functional dressing according to claim 1, wherein: the skin care product comprises 15 parts of bioactive glass, 40 parts of calcium alginate fiber, 15-25 parts of chitosan, 50-90 parts of distilled water, a pH regulator, 3-15 parts of aloe extract, 1-10 parts of triclosan, a skin adhesive, 2-8 parts of polyvinyl alcohol, 1-8 parts of collagen, 2-10 parts of hexamethylene biguanide, 15-25 parts of alginate oligosaccharide, 1-15 parts of radix sophorae flavescentis, 3-12 parts of cortex phellodendri, 5-15 parts of carbomer and 3-10 parts of triethanolamine. The bioactive glass is prepared by adopting leaves of a liliaceae plant as a biological template, and has a nano micropore structure;
the preparation method of the chitosan comprises the steps of calcium removal, deproteinization, purification and deacetylation.
4. A wound healing functional dressing according to any one of claims 1 to 3, wherein: the microporous structure of the bioactive glass is a hollow structure, the micropores are communicated with one another, and the pH value of the wound repair functional dressing is 7-9.
5. A wound repair functional dressing according to claim 4, wherein: the pH adjusting agent includes at least one of citric acid, phosphoric acid, sodium phosphate, and sodium citrate, and the skin adhesive includes at least one of sodium carboxymethyl cellulose and alpha-cyanoacrylate.
6. A wound repair functional dressing according to claim 4, wherein: the preparation method of the chitosan comprises the following steps:
1) calcium removal: pulverizing insect carapace, soaking and boiling in 10-20% diluted acid at 30-50 deg.C for 4-6 hr, filtering, washing filter cake with water for 1-3 times, and drying to obtain decalcified product A;
2) deproteinization: placing the decalcified product A, the complex enzyme and water in a reaction container, controlling the pH of a reaction solution to be 7.5-8.5, stirring and hydrolyzing at 40-55 ℃ for 2-3 hours, filtering, taking a filter cake, washing and drying to obtain a deproteinized product B for later use; the compound enzyme is a mixture of trypsin, papain and alkaline lipase, and the mass ratio of the trypsin to the papain to the alkaline lipase is 1: 1: 2;
3) and (3) purification: placing the deproteinized product B in a mixed solvent, adding neutral salt, stirring and dissolving at 60-80 ℃ for 1-3 hours, filtering, drying the filtrate under reduced pressure to remove the solvent, washing with water to remove the neutral salt, and drying to obtain the required chitin; the mixed solvent is a mixture of caproic acid, oxalic acid and pyridine, and the mass ratio of the caproic acid to the oxalic acid to the pyridine is 1: 0.8: 0.5;
4) deacetylation: and (3) adding the chitin obtained in the step (3) and a 15-20% NaOH aqueous solution into a quartz glass reaction container, placing the quartz glass reaction container under ultraviolet light for irradiating for 2-3 hours, simultaneously carrying out ultrasonic treatment, cooling to room temperature after the reaction is finished, centrifuging, washing the precipitate to be neutral, and drying for 24 hours at 50-60 ℃ to obtain the chitosan.
7. A method of preparing a wound healing functional dressing according to any one of claims 1, 2, 3, 5, 6, characterized in that: the method comprises the following steps:
1) mixing chitosan and polyvinyl alcohol, dissolving the mixture in 20-40% acetic acid water solution in volume ratio to obtain 10% spinning solution, heating in 90 ℃ water bath, stirring for 4-6 hours until the mixture is dissolved, standing and cooling for 2 hours, adding 5-30% calcium alginate fiber into the spinning solution, placing the mixed solution in a constant temperature oscillator at 70 ℃ for magnetic stirring uniformly, standing and defoaming to obtain shell solution;
2) mixing bioactive glass, distilled water, aloe extract, triclosan, collagen, hexamethylene biguanide, fucoidan oligosaccharide, radix sophorae flavescentis, cortex phellodendri, carbomer and triethanolamine at the temperature of 80-110 ℃, stirring, defoaming in vacuum, pouring into a mold, irradiating by adopting an electron beam of 100Gy/S for 8-10 minutes, soaking by adopting deionized water, changing water every 12 hours, repeatedly soaking for 3 times, adding a pH regulator and a skin adhesive, and mixing with a shell solution to obtain the wound repair functional dressing.
8. A wound healing functional dressing according to any one of claims 1 to 3, wherein: the wound repair functional dressing is suitable for burns, incised wounds, operation wounds, cervical erosion, bedsores, sinus tracts, fatty liquefaction wounds, diabetic feet or various skin surface ulcers.
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