CN108210982A - Wound repair dressing and its preparation method and application - Google Patents

Wound repair dressing and its preparation method and application Download PDF

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Publication number
CN108210982A
CN108210982A CN201611195978.3A CN201611195978A CN108210982A CN 108210982 A CN108210982 A CN 108210982A CN 201611195978 A CN201611195978 A CN 201611195978A CN 108210982 A CN108210982 A CN 108210982A
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CN
China
Prior art keywords
wound repair
wound
glass microballoon
repair dressing
bioactivity glass
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Pending
Application number
CN201611195978.3A
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Chinese (zh)
Inventor
张劲松
李保芝
朱礼飞
张宇辰
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Nantong Bluewisdom New Material Co Ltd
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Nantong Bluewisdom New Material Co Ltd
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Priority to CN201611195978.3A priority Critical patent/CN108210982A/en
Publication of CN108210982A publication Critical patent/CN108210982A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/40Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62Encapsulated active agents, e.g. emulsified droplets

Abstract

The present invention provides a kind of wound repair dressing.The wound repair dressing includes bioactivity glass microballoon, aloe extract and triclosan, wherein the content of each substance is:0.5 60 mass parts of bioactivity glass microballoon, 0.001 0.003 mass parts of 0.1 50 mass parts of the aloe extract and the triclosan.The invention further relates to the preparation methods for using above-mentioned wound repair dressing.The wound repair dressing of the present invention has good biocompatibility, can mitigate wound pain, and wound healing is promoted to act on, and its preparation process is simple.

Description

Wound repair dressing and its preparation method and application
Technical field
The present invention relates to a kind of wound repair dressing and its preparation method and application.
Background technology
Bioactivity glass microballoon is made of to natural bone and tooth similar, has higher bioactivity, raw Object compatibility, degradability, no cytotoxicity, and the regeneration of sclerous tissues and soft tissue can be promoted, it is a kind of biology well Active material.
At present, Plus acidic particle to neutralize the bioactivity glass microballoon of alkalinity, and makes institute in wound repair dressing composition It states dressing to be in neutrality or acidity on the weak side, to reach the feeling of pain for mitigating the wounded's wound.However, the bioactivity glass microballoon It is unfavorable for carbonated hydroxyapatite (Hydroxy-carbonate-apatite, abbreviation HCA) with the acidic environment at solution interface The precipitation of phase and crystallization, and HCA has the composition and composition very much like with natural bone inorganic constituents, and with good life Object compatibility.Since the body fluid of wound is usually in acidity, if the dressing used influences the formation of HCA also in acidity, from And reduce the speed of wound healing.In addition, skin is wound, wound is easily dry and cracked because salt analyzes, and wound pain can be caused to aggravate.
Invention content
In view of the foregoing, it is necessary to provide it is a kind of promote wound healing, mitigate wound pain wound repair dressing and Preparation method.
A kind of wound repair dressing, including bioactivity glass microballoon, aloe extract and triclosan, In the content of each substance be:The bioactivity glass microballoon 0.5-60 mass parts, the aloe extract 0.001-0.5 mass Part and the triclosan 0.001-0.003 mass parts.
The wound repair dressing further includes medical glycerine, carbomer, triethanolamine, wherein the content of each substance is:Institute State medical glycerine 1-30 mass parts, the carbomer 0.001-30 mass parts, the triethanolamine 0.001-0.005 mass parts.
The bioactivity glass microballoon is to be made using liliaceous plant leaf as biological template.
The liliaceous plant is selected from liriope platyphylia Wang et Tang, Radix Ophiopogonis, broad-leaved native Radix Ophiopogonis, native Radix Ophiopogonis, evergreen, pink reineckea herb, tawny daylily In a kind of or combination.
The bioactivity glass microballoon has nanoporous structure.
The microcellular structure of the bioactivity glass microballoon is hollow structure, and has connectivity between the micropore.
The pH value of the wound repair dressing is 6-10.
The wound repair dressing is gelling agent or applicator.
A kind of preparation method of wound repair dressing as described above, includes the following steps:
A), raw material is weighed by following weight proportions:Bioactivity glass microballoon 0.5-60 mass parts, aloe extract 0.1- 50 mass parts and triclosan 0.001-0.003 mass parts;
B) raw material, is mixed, at a temperature of 80-110, the wound repair is made into gel in stirring, vacuum defoaming Dressing.
A kind of application of wound repair dressing as described above, it is characterised in that:The wound repair dressing is used as soft group Wound repair materials are knitted, the wound repair dressing is suitable for burn, cut wound, surgical wound surface, cervical erosion, bedsore, sinus, fat Fat liquescency wound, diabetes or all kinds of skin surface ulcer.
Compared with the prior art, above-mentioned wound repair dressing, by adding in bioactivity glass microballoon and aloe extract.Institute Aloe extract is stated with good performance of keeping humidity, human body anti-infection ability can not only be improved, moreover it is possible to promote wound healing And mitigate wound pain, and the formation of scar can be prevented, and bioactivity glass microballoon has good biocompatibility, specific surface Long-pending larger and good gas permeability, therefore, by the aloe extract and bioactivity glass microballoon under certain mass ratio The apparent dressing of curative effect can be formed.
Specific embodiment
As used in this article, term " room temperature " has its general sense well known in the art, and description indoor temperature is 25 DEG C ± 5 DEG C degrees Celsius.
The preparation method of bioactivity glass microballoon of the present invention, specifically comprises the following steps:
(1) acquisition and pre-treat biological template.
The biological template uses liliaceous plant blade, and the liliaceous plant is, for example, but is not limited to broad-leaved wheat Winter, Radix Ophiopogonis, broad-leaved native Radix Ophiopogonis, native Radix Ophiopogonis, evergreen, pink reineckea herb, tawny daylily.It should be understood that the liliaceous plant can be with Selected from the plant with the similar liriope platyphylia Wang et Tang leaf structure.
The liriope platyphylia Wang et Tang also known as " big Radix Ophiopogonis ";The Radix Ophiopogonis also known as " tuber of dwarf lilyturf ", " dwarf lilyturf ";It is described soil Radix Ophiopogonis also known as " Radix Ophiopogonis door ";The pink reineckea herb also known as " purple clothing grass ";And the tawny daylily also known as " day lily ", " day lily ", " deer green onion ", " river grass Flower " etc..
It is the liriope platyphylia Wang et Tang, the Radix Ophiopogonis, the broad-leaved native Radix Ophiopogonis, the native Radix Ophiopogonis, the pink reineckea herb, described evergreen And the tawny daylily is perennial evergreen herbaceous plant, and it is with wide Regional Distribution.Therefore, the liliaceous plant leaf Abundant source can reduce production cost.
It should be understood that the gas on the liriope platyphylia Wang et Tang, the Radix Ophiopogonis, the broad-leaved native Radix Ophiopogonis and the native Radix Ophiopogonis blade Hole moves towards identical in zonal distribution, no accessory cell with blade parallel veins, in two parallelodromous centres.The broad-leaved Radix Ophiopogonis, the described evergreen and pink reineckea herb have a similar stomatal apparatus structure, such as sunken stomata degree unobvious, stomata are big Small and similar density.The Radix Ophiopogonis, the native Radix Ophiopogonis, the sunken stomata degree of the broad-leaved native Radix Ophiopogonis and the tawny daylily are brighter It is aobvious, and stomata is smaller, stomatal frequency is big.Since the size of stomata, distribution and density can influence the bioactivity glass microballoon The infiltration of contained active constituent and preservation effect, therefore the preferred stomata of liliaceous plant blade is larger, pore opening is poor Different relatively small and gas cell distribution is smooth, uniform blade.
It should be understood that have compared to the Radix Ophiopogonis, the broad-leaved native Radix Ophiopogonis and the native Radix Ophiopogonis, the liriope platyphylia Wang et Tang Pore opening difference is relatively small, the upper and lower epidermis of blade all has gas cell distribution, and the stoma number of lower epidermis is far more than upper table Skin, the epidermal cell percilinal wall at stomatal band make sunken stomata with respect to unobvious substantially without protrusion.Further, since described ten thousand Young and described pink reineckea herb has the stomatal apparatus structure similar to the liriope platyphylia Wang et Tang.Therefore, the preferred institute of the liliaceous plant It states from liriope platyphylia Wang et Tang, the described evergreen and pink reineckea herb.
The liriope platyphylia Wang et Tang belongs to monocotyledon, and blade is linear, and vein is parallel train of thought.There is tubular structure in vein Vascular bundle be interlaced with one another connection through entire blade, form the skeleton of transporting moisture, inorganic salts and organic substance.Blade Oval stomata is dispersed on epidermis, and longitudinal stomatal band is formed between vein, convenient for the exchange of substance inside and outside leaf.Mesophyll is thin Born of the same parents' arrangement is loose, and gap is larger, and has big central vacuole in mesophyll cell.The structure feature of the liriope platyphylia Wang et Tang is easy to Substance gos deep into blade interior and deposits, and then forms the material with hierarchical porous structure.
A) fresh liliaceous plant leaf is taken, the blade that specification is of moderate size is cut into, is cleaned 2-5 times with EtOH Sonicate, To remove the impurity of leaf surfaces.
It should be understood that those skilled in the art personnel it will be appreciated that, the liliaceous plant leaf can be cut into not The blade of same specification size, and shape is unrestricted.
Preferably, in order to ensure the liliaceous plant leaf cleaning is more thorough, and during follow-up participation reaction, described in reduction Reunite between liliaceous plant blade and occur, the liliaceous plant blade cuts into strip shape, and specification size is preferred For 5mm × 10mm.Therefore, the liliaceous plant blade can fully be reacted in immersion fluid.
B) the liliaceous plant blade after activation process cleaning.
Liliaceous plant blade after cleaning is impregnated in 50% ethanol solution, adds in pH adjusting agent to adjust solution PH value is about 2-5, and adds in activator activation process 18-48 hours, to remove the gold of the liliaceous plant blade interior Belong to impurity and part dissolved organic matter.
It should be understood that the activation process of the liliaceous plant blade can make it still keep natural ecology, light Pool and elasticity are without wilting.
The activator is, for example, but is not limited to, methanol, ethylene glycol, polyethylene glycol or glycerine.
Preferably, the activator is polyethylene glycol.
The pH adjusting agent is acid reagent.
The acid reagent is, for example, but is not limited to, hydrochloric acid or nitric acid.
Preferably, the acid reagent is hydrochloric acid.
Preferably, the pH value of the solution is about 3.
Preferably, the time of the activation process is 24 hours.
C) it takes out the liliaceous plant blade after activation process and is rinsed with washing lotion, until the washing lotion after rinsing is in neutrality, The liliaceous plant blade is dried again, to obtain pore creating material.
The washing lotion is, for example, but is not limited to, deionized water, pure water, distilled water or buffer solution, to remove described hundred Remaining acid reagent on conjunction section plant leaf blade.
It should be understood that due to containing micro metal ion, the preferred deionization of washing lotion in the buffer solution Water, pure water or distilled water.
(2) precursor liquid of bio-vitric activity glass ball is prepared.
A) at room temperature, by 0.01-20g nonionic block copolymers stirring and dissolvings, in 10-500g ethyl alcohol/distilled water In, and 40-45 DEG C is adjusted the temperature to, micellization occurs for the nonionic block copolymers, to obtain opalescent solution.
It should be understood that the solvent used in the nonionic block copolymers dissolving is in water, distilled water, ethyl alcohol A kind of or combination.
Preferably, the solvent is the ratio example of ethyl alcohol and the mixed solution of distilled water, the ethyl alcohol and the distilled water If so, it but is not limited to, 100:0、1:1、2:1 or 0:100.
It should be understood that in order to control the solution concentration after the nonionic block copolymers generation micellization, it is described The ratio of ethyl alcohol and the distilled water is preferably 1:1.
It should be understood that in micellization generating process, when solution from it is colourless become milky after, stopping heating simultaneously makes institute The temperature for stating solution is down to room temperature.
The nonionic block copolymers are selected from F127 (molecular formula EO106PO70EO106) or P123, and (molecular formula is PEO-PPO-PEO)。
Since during the precursor liquid for preparing bioactivity glass microballoon, the calcium of generation product can be reduced using F127 Ion concentration, therefore, the nonionic block copolymers are preferred P123.A concentration of 0.5-15% of the P123.
B) at ambient temperature, by 0.1-10g triethyl phosphates, 1-20g ethyl orthosilicates, 0.5-5g acidic catalysts, 98% γ of 0.1-30g-glycidyl ether oxygen propyl trimethoxy silicane and 0.1-50g calcium sources are added in above-mentioned solution, and stir 16-30 hours, bioactivity glass microballoon precursor liquid is made.
A kind of or combination of the calcium source in calcium oxide, calcium carbonate, calcium nitrate, calcium sulfate, calcium silicates.
Preferably, the calcium source is calcium nitrate.
Preferably, the calcium nitrate is four water-calcium nitrate (molecular formula, Ca (NO3) 24H2O).It should be understood that from life The surface release calcium ion of object activity glass microballoon helps to form the layer rich in calcium phosphate on the glass surface.
The one kind of the acidic catalyst in hydrochloric acid or hydrofluoric acid.
Preferably, the acidic catalyst is hydrochloric acid.
(3) pore creating material is immersed in the bioactivity glass microballoon precursor liquid;
The pore creating material is added in the bioactivity glass microballoon precursor liquid, and is impregnated at being 10-40 DEG C in temperature 24 hours.The dosage of the pore creating material is 0.5-100g, and the dosage of the bioactivity glass microballoon precursor liquid is 10-1000g, To realize that reacting between the pore creating material and the bioactivity glass microballoon precursor liquid is smoothed out.
It, not only can be with it should be understood that by the bioactivity glass microballoon precursor liquid for preparing of pore creating material addition The stomata of the pore creating material is avoided to be blocked, additionally it is possible to the active constituent contained by the bioactivity glass microballoon be made equably to divide It dissipates and adsorbs in pore creating material.
(4) product after dipping is taken out, successively through over cleaning, drying, calcining, to obtain bioactivity glass microballoon.
The pore creating material being immersed in the bioactivity glass microballoon precursor liquid is taken out, is then cleaned with the EtOH Sonicate 1-5 hours;Product after cleaning is taken out, and it is 48 hours dry at 20-60 DEG C of temperature after, be 450-700 DEG C in temperature 3-8h is calcined under air conditions, to remove template, to obtain bioactivity glass microballoon.
The bioactivity glass microballoon has microcellular structure, and the aperture of the microcellular structure is 1-30nm.The micropore Structure is hollow structure.In addition, there is connectivity, to improve gas permeability and carry between the micropore of the bioactivity glass microballoon High-specific surface area, and the outer surface of the bioactivity glass microballoon is more smooth, to reduce bioactivity glass microballoon Active constituent directly reacts with skin wound, hinders wound person so as to mitigate and is using containing bioactivity glass microballoon Caused severe pain sense during drug.
It should be understood that since the bioactivity glass microballoon has hollow microcellular structure, and microcellular structure has Connectivity, so as to which the bioactivity glass microballoon specific surface area is larger, therefore good permeability, reaction speed are fast, can obtain Quick therapeutic effect.
The preparation method for preparing bioactivity glass microballoon of the present invention, by using the liliaceous plant leaf of abundance Son is as biological template, so as to reduce production cost.Further, since liliaceous plant leaf has special air hole structure, Enable bioactivity glass microballoon active constituent effectively, be uniformly dispersed and adsorb in the liliaceous plant leaf Interior, so as to prepare good biocompatibility, specific surface area is larger and the bioactivity glass microballoon of good air permeability.
It should be understood that the bioactivity glass microballoon is used to prepare wound repair dressing.
The wound repair dressing of the present invention includes bioactivity glass microballoon, aloe extract, the dichloro-benzenes of above-mentioned preparation Oxygen chlorophenol, medical glycerine, carbomer and triethanolamine, wherein the content of each substance is:The bioactivity glass microballoon 0.5-60 mass parts, the aloe extract 0.001-0.5 mass parts, the triclosan 0.001-0.003 mass parts, The medical glycerine 1-30 mass parts, the carbomer 0.001-30 mass parts and the triethanolamine 0.001-0.005 matter Measure part.
The bioactivity glass microballoon is using liliaceous plant leaf as biological template.
It should be understood that the liliaceous plant leaf is selected as biological template can influence the bioactivity glass and is micro- The microcellular structure that ball is formed.
The liliaceous plant is selected from Radix Ophiopogonis, liriope platyphylia Wang et Tang, native Radix Ophiopogonis, broad-leaved native Radix Ophiopogonis, evergreen, pink reineckea herb, tawny daylily In a kind of or combination.
Preferably, the liliaceous plant is selected from the liriope platyphylia Wang et Tang, the described evergreen or pink reineckea herb.
The bioactivity glass microballoon has microcellular structure, and the aperture of the micropore is 1-30nm.The bioactivity The microcellular structure of glass microsphere is hollow nanostructured, and has connectivity between the micropore.
It should be understood that since the bioactivity glass microballoon has hollow microcellular structure, so as to which the biology is living Property glass microsphere specific surface area is larger, therefore good permeability, reaction speed are fast, can obtain quick therapeutic effect.
The wound repair dressing meta-alkalescence, the pH value of the wound repair dressing is about 6-10.
It should be understood that the catabolite of the bioactivity glass microballoon can promote the generation of growth factor, and promote Into the procreation of cell, so as to realize the effect for promoting wound healing.Specifically, when the bioactivity glass ball acts on During wound tissue, the alkali metal ion dissolving contained by bioactivity glass microballoon described first is discharged into ambient body fluid, with body H in liquid+It exchanges, so as to form silicon-rich layer in material surface, silicon-rich layer absorbs the Ca in ambient body fluid as equiax crystal2+、 PO4 3-And OH-Ion forms apatite layer.The apatite layer originally formed is amorphous, and may then be inhaled in growth process Receive the CO in tissue3 2-The gradually similar HCA crystal of the ingredient of crystallization adult body bone.In apatite forming process, the biology The release of contained calcium ion increases the degree of supersaturation in ambient body fluid in activity glass microballoon, and silicon ion is material surface phosphorus The formation of lime stone provides advantageous nucleation site.Therefore, the bioactivity glass microballoon and the alkaline environment at solution interface Be conducive to the precipitation and crystallization of carbonated hydroxyapatite (Hydroxy-carbonate-apatite, abbreviation HCA) phase.In addition, institute HCA is stated with the composition and composition very much like with natural bone inorganic constituents, and with good biocompatibility, so as to make Obtain the quick reparation that the HCA may advantageously facilitate the biological tissue that is wound.Therefore, in order to neutralize be wound wound location generation acidity Substance and ensure to form carbonated hydroxyapatite (HCA), the pH value of the wound repair dressing is preferably 8.
The wound repair dressing is gelling agent or applicator.
The aloe extract contains control cell growth and the ingredient broken up, moisturizing ingredient, anti-infective ingredient, stimulation in vain The ingredient of cell and other immune cell growths, the ingredient for promoting callus.For example, the aloe extract contains various active Enzyme.The organized enzyme includes, but are not limited to, and catalase, amylase, oxidizing ferment, cellulase, lipase, plant coagulate Sanguinin.The lectins can be attached on human body cell, natural growth factor in human activin cell, stimulate cell interior Reaction promotes cell growth and division, accelerates wounded tissue rehabilitation and healing, enhances lymphocyte function, so as to improve human body The ability of various diseases is resisted, improves human body anti-infection ability.
It should be understood that when skin injury, the evaporation of moisture of skin easily accumulates salinity, therefore internal moisture in wound It can largely be siphoned away by salt, so that the cell mortality of wound surface, so as to cause wound pain.Therefore, it is applied in the surface of a wound The aloe extract with moisture-keeping function is added in material, the skin wound that can be avoided exposure in air is precipitated salinity and occurs It is dry and cracked, so as to mitigate wound pain.
In addition, the aloe extract has good biocompatibility, skin compatibility, film forming, gas permeability, moisturizing Property.Since the aloe extract can not only improve human body anti-infection ability, moreover it is possible to promote wound healing, and scar can be prevented The formation of trace, therefore the aloe extract and bioactivity glass microballoon can be formed into curative effect under certain mass ratio Apparent dressing.
The glycerine has plasticising and low-temperature protection effect, so as to improve the mechanical property of above-mentioned dressing and surface topography.
The triclosan also known as " triclosan ", " triclosan ", " Triclosan " etc..The triclosan is one Kind broad spectrum antimicrobial agent, to causing infection or pathogenicity Gram positive mattress, true mattress, yeast and virus (such as first, hepatitis B, rabies Poison, AIDS virus HIV) etc. all there is extensive kill and inhibiting effect.Therefore, the surface of a wound of animal body is not easy bacterial infection or disease Poison is conducive to quickly repair the tissue that is wound.
In the present embodiment, the carbomer is Acritamer 940 GE, wherein, GE represents pharmaceutical grade.
It should be understood that the carbomer is poly- alkyl sucrose or poly- alkyl pentaerythrite and acrylic crosslinking polymer Copolymer.Due to containing acid groups in the carbomer molecular structure, so as to have certain acidity, therefore the wound can be neutralized The partial alkaline substance in dressing is repaired in face, to reduce stimulation of the wound repair dressing to skin.The carbomer is through institute After stating alkaline matter neutralization, contained carboxylic ions in the carbomer molecular structure, due to the mutually exclusive work of negative electrical charge With so that strand disperse is stretched, and in great swelling state, and has viscosity, so as to form gel.In addition, the carbomer With stronger hygroscopicity, therefore it can absorb the body fluid that wound location generates that is wound, and promote the body fluid and institute It states component contained in bioactivity glass microballoon and plysiochemical reaction occurs.
The triethanolamine is in alkalinity, and the triethanolamine is for neutralizing carbomer, to form stable macromolecular structure, Reach the application effect of thickening and moisturizing.The triethanolamine is soluble in the medical glycerine.
It will be appreciated by those skilled in the art that the solvent of the wound repair dressing is not limited to the medical glycerine, described Carbomer and the triethanolamine, other can realize that the liquid of the wound repair dressing composition dissolving can be used for this hair It is bright.
The method of the wound repair dressing, includes the following steps in the preparation of the present invention:
A), raw material is weighed by following weight proportions:The bioactivity glass microballoon 0.5-60 mass parts, the aloe carry Take object 0.001-0.5 mass parts, the triclosan 0.001-0.003 mass parts, the medical glycerine 1-30 mass parts, The carbomer 0.001-30 mass parts and the triethanolamine 0.001-0.005 mass parts.
It should be understood that the carbomer can be mixed first with the triethanolamine, to avoid in the carbomer and institute Bioactivity glass microballoon is stated, so that it is guaranteed that physiology occurs is anti-for the active constituent of the bioactivity glass microballoon and wound tissue Alkaline environment can be directly provided at once.
B) raw material, is mixed, at a temperature of 80-110, stirring, vacuum defoaming are made described living containing biology into gel The dressing of property glass microsphere.
The present invention wound repair dressing preparation method by the way that each component is mixed, and under preference temperature carry out into The processing such as type, drying, you can obtain product, preparation method is simple for process, and condition is easily-controllable, and of low cost, suitable for making extensively With.
The wound repair dressing of the microballoon containing bioactivity glass of the present invention is used as soft tissue wound repair materials, is suitable for Burn, cut wound, surgical wound surface, cervical erosion, bedsore, sinus, liquefaction of fat wound, diabetes and all kinds of skin surfaces are burst The chronic large area surface of a wound such as ulcer.
The present invention is specifically described below by embodiment.
In the present embodiment, the biological template uses liriope platyphylia Wang et Tang leaf and evergreen leaf, and the pH adjusting agent is Hydrochloric acid, the nonionic block copolymers are P123.The activator is polyethylene glycol.The washing lotion is pure water.It is described Calcium source is four water-calcium nitrate.
Embodiment 1
(1) pretreatment of liriope platyphylia Wang et Tang leaf:
Fresh liriope platyphylia Wang et Tang leaf is chosen, is cut into the blade of 5mm × 10mm sizes, is cleaned 3 times with EtOH Sonicate.Then Liriope platyphylia Wang et Tang blade after cleaning is placed in 50% ethanol solution, the pH value for adding in hydrochloric acid conditioning solution is about 3, and is added in Polyethylene glycol activation process is for 24 hours.The liriope platyphylia Wang et Tang blade after activation process is taken out, and is rinsed with pure water, until after rinsing Washing lotion is in neutrality, then dries the liriope platyphylia Wang et Tang blade, pore creating material is made.
(2) precursor liquid of bioactivity glass microballoon is prepared.
At room temperature, by 5g P123 stirring and dissolvings in 15g ethyl alcohol/distilled water (ratio 1:1) it in, and adjusts the temperature to 45 DEG C, micellization occurs for the P123, to obtain opalescent solution.
When above-mentioned solution is down to room temperature, by 1g triethyl phosphates, 8g ethyl orthosilicates, 1g acidic catalysts, 2g 98% γ-glycidyl ether oxygen propyl trimethoxy silicane and 2g four water-calcium nitrates are added in above-mentioned solution, and are stirred 24 hours, with system Obtain bioactivity glass microballoon precursor liquid.
(3) bioactivity glass microballoon is prepared.
It weighs pore creating material described in 20g to add in bioactivity glass microballoon precursor liquid described in 500g, and is 40 DEG C in temperature It is lower to impregnate 24 hours;Product after impregnating is then taken out, is cleaned 2 hours with EtOH Sonicate;By the product after cleaning in temperature 50 C After lower drying 48 hours, 3h is calcined in the case where temperature is 700 DEG C of air conditions, to remove template, to obtain bioactivity glass Microballoon.
(4) wound repair dressing is prepared.
Raw material is weighed by following weight proportions:10 mass parts of bioactivity glass microballoon of the preparation of embodiment 1, the aloe 20 mass parts of extract, 0.001 mass parts of the triclosan, 10 mass parts of the medical glycerine, 5 matter of the carbomer Measure 0.002 mass parts of part and the triethanolamine.
The raw material is mixed, at a temperature of 80 DEG C, stirring, vacuum defoaming are made described and contain bioactivity glass into gel The wound repair dressing of glass microballoon.
Embodiment 2
(1) pretreatment of evergreen leaf:
Fresh evergreen leaf is chosen, is cut into the blade of 5mm × 10mm sizes, is cleaned 3 times with EtOH Sonicate.Then will Evergreen blade after cleaning is placed in 50% ethanol solution, and the pH value for adding in hydrochloric acid conditioning solution is about 3, and adds in poly- second Glycol activation process is for 24 hours.The evergreen blade after activation process is taken out, and is rinsed with pure water, until the washing lotion after rinsing is in Neutrality, then the evergreen blade is dried, pore creating material is made.
(2) precursor liquid of bioactivity glass microballoon is prepared.
At room temperature, by 5g P123 stirring and dissolvings in 15g ethyl alcohol/distilled water (ratio 1:1) it in, and adjusts the temperature to 45 DEG C, micellization occurs for the P123, to obtain opalescent solution.
When above-mentioned solution is down to room temperature, by 1g triethyl phosphates, 8g ethyl orthosilicates, 1g acidic catalysts, 2g 98% γ-glycidyl ether oxygen propyl trimethoxy silicane and 2g four water-calcium nitrates are added in above-mentioned solution, and are stirred 24 hours, with system Obtain bioactivity glass microballoon precursor liquid.
(3) bioactivity glass microballoon is prepared.
It weighs pore creating material described in 20g to add in bioactivity glass microballoon precursor liquid described in 500g, and is 40 DEG C in temperature It is lower to impregnate 24 hours;Product after impregnating is then taken out, is cleaned 2 hours with EtOH Sonicate;By the product after cleaning in temperature 50 C After lower drying 48 hours, 3h is calcined in the case where temperature is 700 DEG C of air conditions, to remove template, to obtain bioactivity glass Microballoon.
(4) wound repair dressing is prepared.
Raw material is weighed by following weight proportions:10 mass parts of bioactivity glass microballoon of the preparation of embodiment 2, the aloe 20 mass parts of extract, 0.001 mass parts of the triclosan, 10 mass parts of the medical glycerine, 5 matter of the carbomer Measure 0.002 mass parts of part and the triethanolamine.
The raw material is mixed, at a temperature of 80 DEG C, stirring, vacuum defoaming are made described and contain bioactivity glass into gel The wound repair dressing of glass microballoon.
The preparation method of the bioactivity glass microballoon of the present invention, the leaf by using liliaceous plant are biological mould Plate, by using of low cost, and the liliaceous plant leaf of abundance is produced into as biological template so as to reduce This.Further, since liliaceous plant leaf has special air hole structure so that the active constituent energy of bioactivity glass microballoon Enough effectively, it is uniformly dispersed and adsorbs in the liliaceous plant leaf, so as to prepare good biocompatibility, compare table Area is larger and the bioactivity glass microballoon of good air permeability.The wound of preparation microballoon containing bioactivity glass of the present invention Face repair dressing method is not only simple for process, condition is easily-controllable, and cost is simple, suitable for industrialized production.The surface of a wound of the present invention It repairs dressing and includes bioactivity glass microballoon and aloe extract, since there is the bioactivity glass microballoon special hole to tie Structure, bioactivity glass microballoon has good biocompatibility, and the aloe extract can not only improve the anti-sense of human body Dye ability, moreover it is possible to promote wound healing, and the formation of scar can be prevented.Therefore, the wound repair dressing can be treated quickly The wound of the wounded, moreover it is possible to mitigate the feeling of pain of the wounded over the course for the treatment of.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment Limitation, embodiment of above are only for interpreting the claims.Right protection scope of the present invention is not limited to specification.Appoint What those familiar with the art is in the technical scope of present disclosure, the variation or replacement that can readily occur in, It is included within protection scope of the present invention.

Claims (10)

1. a kind of wound repair dressing, including bioactivity glass microballoon, aloe extract and triclosan, wherein The content of each substance is:The bioactivity glass microballoon 0.5-60 mass parts, the aloe extract 0.001-0.5 mass parts And the triclosan 0.001-0.003 mass parts.
2. wound repair dressing as described in claim 1, it is characterised in that:The wound repair dressing further includes medical sweet Oil, carbomer, triethanolamine, wherein the content of each substance is:The medical glycerine 1-30 mass parts, the carbomer 0.001- 30 mass parts, the triethanolamine 0.001-0.005 mass parts.
3. wound repair dressing as described in claim 1, it is characterised in that:The bioactivity glass microballoon is using lily Section's plant leaf is made as biological template.
4. wound repair dressing as claimed in claim 3, it is characterised in that:The liliaceous plant is selected from liriope platyphylia Wang et Tang, wheat A kind of or combination in winter, broad-leaved native Radix Ophiopogonis, native Radix Ophiopogonis, evergreen, pink reineckea herb, tawny daylily.
5. wound repair dressing as described in claim 1, it is characterised in that:The bioactivity glass microballoon is micro- with nanometer Pore structure.
6. wound repair dressing as described in claim 1, it is characterised in that:The microcellular structure of the bioactivity glass microballoon For hollow structure, and there is connectivity between the micropore.
7. wound repair dressing as described in claim 1, it is characterised in that:The pH value of the wound repair dressing is 6-10.
8. wound repair dressing as described in claim 1, it is characterised in that:The wound repair dressing is gelling agent or application Agent.
9. a kind of preparation method for preparing the wound repair dressing in claim 1-8 described in any one, including following step Suddenly:
A), raw material is weighed by following weight proportions:Bioactivity glass microballoon 0.5-60 mass parts, aloe extract 0.1-50 matter Measure part and triclosan 0.001-0.003 mass parts;
B) raw material, is mixed, at a temperature of 80-110, stirring, vacuum defoaming are made the wound repair and apply into gel Material.
10. a kind of application of wound repair dressing as described in claim 1, it is characterised in that:The wound repair dressing is used Make soft tissue wound repair materials, the wound repair dressing be suitable for burn, cut wound, surgical wound surface, cervical erosion, bedsore, Sinus, liquefaction of fat wound, diabetes or all kinds of skin surface ulcer.
CN201611195978.3A 2016-12-22 2016-12-22 Wound repair dressing and its preparation method and application Pending CN108210982A (en)

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Application publication date: 20180629