JP2009108008A - Gel sheet and sheet-like cosmetic using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a gel sheet quickly supplying a component supported by hydrogel to a desired area in an adherend by bringing the component into contact with the adherend and a sheet-like cosmetic having excellent moisture retaining property and skin barrier properties by using the gel sheet. <P>SOLUTION: The gel sheet has an integrated structure of a support substrate and hydrogel and has a syneresis ratio of ≥40 mass% and ≤90 mass% when brought into contact with filter paper for 10 minutes. The sheet-like cosmetic uses the gel sheet. Preferably the gel sheet comprises hydrogel that contains a polysaccharide, a polyether, an O/W type emulsion, collagen or its decomposition product and has a water content of ≥70 mass% and ≤95 mass%. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a gel sheet used in the fields of pharmaceuticals, quasi drugs, cosmetics, hygiene materials, sundries, and the like, and a sheet-like cosmetic using the gel sheet.

  Conventionally, gel sheets have been used in packs and patches used for beauty, facial treatment, skin treatment, and the like, carriers for active ingredients such as skin permeation components and anti-inflammatory analgesic components, and living bodies intended for wound protection and drug immobilization. Used in adhesive tapes and wound dressings. These gel sheets are, for example, the skin as an adherend. By sticking to the skin, for example, the moisture content (water retention) of the skin surface is increased, the skin temperature is controlled, and the active ingredient in the gel sheet Functions such as supplying to the skin. In particular, by aging the gel sheet in close contact with the skin, the skin temperature and the amount of water are improved, thereby increasing the physiological function of the skin and further increasing the penetration of the active ingredients in the gel sheet into the skin. It can also be increased.

As a gel sheet having such an action, it is known that a polysaccharide such as collagen, chitin, chitosan, alginic acid, or cellulose is used as a constituent component as a gel base material in consideration of use in a living body (for example, , See Patent Document 1).
In addition, for the purpose of improving the moisture retention of the skin, a technique for promoting a bleeding effect from a gel base material with a specific alkylene oxide derivative (see, for example, Patent Document 2), or a solution leaching effect by adding polyethylene glycol or an electrolyte A technique (for example, see Patent Document 3) that promotes the above is known.

In order to quickly supply various components such as moisture and functional components retained in the gel sheet to the target area of the adherend such as the skin, not only the performance of retaining the components in the gel but also in the gel The gel sheet is required to have the ability to quickly release the various components retained in the gel to the adherend when the components are adhered to the adherend. However, it has been difficult for the above-described techniques to satisfy such requirements. Therefore, for example, a gel sheet that can rapidly supply and penetrate various components such as moisture and functional components while maintaining moisture retention on the skin surface has not yet been provided. It is.
Japanese Patent Laid-Open No. 3-81213 JP 2005-225837 A JP 2003-183147 A

  An object of the present invention made in view of the above circumstances is to provide a gel sheet that can quickly supply a component retained in a hydrogel to a desired region in the adherend by contact with the adherend, and the gel sheet. An object of the present invention is to provide a sheet-like cosmetic having excellent moisture retention and skin barrier properties.

Means for solving the above-described problems are as follows.
<1> A gel sheet having a structure in which a supporting base material and a hydrogel are integrated, and having a separation rate of 40% by mass or more and 90% by mass or less when contacted with a filter paper for 10 minutes.
<2> The gel sheet according to <1>, wherein the hydrogel has a water content of 70% by mass or more and 95% by mass or less.
<3> The gel sheet according to <1> or <2>, wherein the hydrogel contains a polysaccharide.
<4> The gel sheet according to any one of <1> to <3>, wherein the hydrogel includes a polyether.
<5> The gel sheet according to any one of <1> to <4>, wherein the hydrogel includes an O / W emulsion.
<6> The gel sheet according to any one of <1> to <5>, wherein the hydrogel contains at least one selected from collagen or collagen degradation products.
<7> The gel sheet according to any one of <1> to <6>, wherein the hydrogel contains a polyhydric alcohol compound.
<8> The gel sheet according to any one of <1> to <7>, wherein the hydrogel includes a water-soluble divalent metal salt. <9> The hydrogel layer including the hydrogel, and the hydrogel layer <10> The gel sheet has a thickness of 0.4 mm or more and 2 mm or less. <1> The sheet-like support base provided in or adjacent to the hydrogel layer Gel sheet in any one of <9>.
<11> A sheet-like cosmetic using the gel sheet of any one of <1> to <10>.

  The gel sheet of the present invention is intended for packs and patches used for beauty treatment, facial treatment and skin treatment, carriers for functional components such as skin penetration components and anti-inflammatory analgesic components, wound protection and drug immobilization, etc. It includes living body adhesive tapes, wound dressings and the like. More specifically, the gel sheet of the present invention is directly applied to the adherend for the purpose of allowing each component held in the hydrogel such as a functional component or moisture to permeate the adherend such as the skin. It is suitable as a pressure-sensitive adhesive sheet for a living body that is used by being attached. Moreover, this gel sheet is useful as a sheet-like cosmetic material such as a pack for attaching to the skin and giving moisture and functional components to the skin.

  According to the present invention, a gel sheet that can quickly supply a component held in a hydrogel to a desired region in the adherend by contact with the adherend, and moisture retention and skin using the gel sheet A sheet-like cosmetic material having excellent barrier properties can be provided.

  Hereinafter, the gel sheet of the present invention and the sheet-like cosmetic using the same will be described in detail.

[Gel sheet]
The gel sheet of the present invention has a structure in which a supporting substrate and a hydrogel are integrated, and has a separation rate of 40% by mass or more and 90% by mass or less when contacted with a filter paper for 10 minutes.

  The gel sheet of the present invention is characterized in that the separation rate upon contact with the filter paper for 10 minutes is 40% by mass or more and 90% by mass or less. The separation rate of the gel sheet is more preferably 45% by mass or more and 85% by mass or less from the viewpoint of the release efficiency of the components retained by the hydrogel to the adherend and the storage stability of the gel sheet. It is particularly preferable that the content is not less than 80% by mass.

  Since the gel sheet of the present invention has a high separation rate, the component retained in the hydrogel by contact with the adherend can be quickly supplied to a desired region on the adherend. Therefore, when the gel sheet of the present invention is configured as, for example, a biological gel sheet and brought into contact with the epidermis, moisture can be efficiently supplied to the stratum corneum. It is possible to improve the permeability to the stratum corneum of various components blended to improve physiological activity.

The separation rate in the gel sheet of the present invention is a value calculated by the following measurement test.
-Measurement test-
A gel sheet was cut to 3 cm × 3 cm to prepare a sample, and this sample was obtained from Advantech Toyo Co., Ltd. filter paper No. 9 having a diameter of 9 cm. 2 (two types of qualitative filter papers defined in JIS P3801 (1995 edition): 125 g / m ² , thickness 0.26 mm, drainage time 80 seconds, water absorption 80 cm) The change in filter paper mass is measured after standing for 10 minutes in an environment of 50 ° C. and 10% relative humidity. Using the obtained measured value, the separation rate is calculated by the following formula (1).
Separation rate (mass%) = (filter paper absorption mass / gel initial mass * 100) (Equation 1)
In said formula (1), "gel initial mass" is a value obtained by remove | excluding the mass of a support base material from the mass of a gel sheet sample piece.
The average value of the values obtained by repeating the above measurement test 5 times is defined as the separation rate.

  For the method of measuring the detachment rate, for example, the method described in “Fragrance Journal”, June 2007, pages 95 to 102 can be referred to.

  For example, when the gel sheet of the present invention is configured as a biological gel sheet, the water content retained by the hydrogel can be evaluated by evaluating the separation rate of the gel sheet based on the liquid absorption mass to the filter paper that is an adherent having water absorption. And each component such as a functional component is preferable as an index as to whether or not the gel sheet and the adherend such as the epidermis can efficiently penetrate into the skin.

  The water content of the hydrogel in the gel sheet of the present invention is preferably 70% by mass to 95% by mass, more preferably 75% by mass to 95% by mass, and particularly preferably 80% by mass to 90% by mass. When the water content of the hydrogel layer is within this range, not only the release efficiency of the functional component that can be contained in the hydrogel layer is improved, but also the strength of the hydrogel layer is kept high. In addition, when the gel sheet is configured for a living body, it is possible to further reduce irritation while improving the permeability of the functional component to the adherend such as the epidermis.

The water content of the hydrogel can be measured from the mass reduction rate associated with heat drying or reduced pressure drying. Specifically, 1 g of hydrogel is taken out from the gel sheet, dried under reduced pressure at 25 ° C. until no change in mass of the sample is observed, and the value calculated by the following formula (2) is taken as the water content.
Moisture content (mass%) = (initial mass−mass after drying) / initial mass * 100 (Equation 2)
The average value of the values obtained by repeating the above measurement test five times is defined as the moisture content.
The water content of the hydrogel in this specification is measured by the above method.

  The water content of the hydrogel can also be measured with a Karl Fischer, infrared, or electrical resistance moisture meter. Moreover, when hydrogel compounded liquid itself gelatinizes, the mixing rate of a water | moisture content can be made into the moisture content of a gel.

  The gel sheet of the present invention is a gel sheet excellent in releasing property, and the moisture content of the hydrogel is within the above-mentioned preferable range, and various functional components are contained therein, and thus such a functional component is applied. It is possible to efficiently penetrate a predetermined region of the body, for example, a living body. For this reason, the gel sheet of this invention can be used conveniently as a sustained-release support body and cosmetics of an active ingredient.

  Here, “separation” in this specification means that the liquid component (serum water) contained in the hydrogel exudes from the hydrogel and moves to the adherend due to contact between the gel sheet and the adherend. Refers to the function to perform. The liquid component exuded from the hydrogel in the present invention includes emulsion particles, fine solid particles and the like in addition to water and aqueous components present in the hydrogel. Therefore, the gel sheet of the present invention can effectively supply water-soluble or oil-soluble functional components retained in the hydrogel in addition to moisture to the adherend.

  The hydrogel in the present invention can be prepared by combining the following components. Hereinafter, each component which the hydrogel which is a component of the gel sheet of this invention may contain is demonstrated in detail.

<Polyether>
The hydrogel in the present invention preferably contains a polyether. Polyethers can promote gelling properties of gel sheets.

  Examples of the polyether include polyethylene oxide, polypropylene oxide, polyethylene oxide / polypropylene oxide block copolymer, polyethylene oxide / polypropylene oxide / polyethylene oxide block copolymer, and a block polymer containing polyethylene oxide and polypropylene oxide is particularly preferable. Specifically, a polyethylene oxide / polypropylene oxide block copolymer or a polyethylene oxide / polypropylene oxide / polyethylene oxide block copolymer (hereinafter sometimes abbreviated as “PEO-PPO-PEO block polymer”) is particularly preferable. These polyethers are known as poloxamers, such as “Pluronic”, “Lutrol” (both manufactured by BASF), New Pole (manufactured by Sanyo Chemical Industries), Epan (Daiichi Kogyo Seiyaku Co., Ltd.) And Pronon (manufactured by Nippon Oil & Fats Co., Ltd.).

  The weight average molecular weight (Mw) of the polyether is preferably 1,000 to 1,000,000, and more preferably 5,000 to 500,000.

  The content of the polyether in the hydrogel is preferably 0.05 to 20% by mass, more preferably 0.1 to 10% by mass, and particularly preferably 0.2 to 5% by mass. If the content of the polyether is 0.05% by mass or more, the liquid component contained in the hydrogel is likely to exude, for example, an effect of improving skin permeability is obtained, and if it is 20% by mass or less, It can prevent that the storage stability of a gel sheet falls remarkably.

<Polysaccharides>
The hydrogel in the present invention preferably contains a polysaccharide. The polysaccharide improves the handleability of the gel sheet.

  Examples of polysaccharides that can be used in the present invention include neutral polysaccharides (eg, cellulose, amylose, amylopectin, dextran, pullulan, inulin, galactan, mannan, xylan, arabinan, glucomannan, galactomannan, agarose, methylcellulose. , Hydroxypropylcellulose, curdlan, xyloglucan, etc.), anionic polysaccharides (pectinic acid, alginic acid, agarose, agar, carrageenan, fucoidan, hyaluronic acid, chondroitin sulfate, heparin, gellan gum, native gellan gum, xanthan gum, carboxymethylcellulose, carboxy Methyl starch, carboxymethyl dextran, etc.), cationic polysaccharides (chitin, chitosan, cationized cellulose, cationized starch) And cationic dextran), and the like.

  Among these, as the polysaccharide, a polysaccharide having a high thickening gelling action is more preferable, and glucomannan, galactomannan, agar, carrageenan, gellan gum, native gellan gum, and xanthan gum are particularly preferable. Furthermore, in order to improve the gelation property, two or more of these polysaccharides may be used in combination.

  The content of the polysaccharide in the hydrogel is preferably 0.01 to 5% by mass, more preferably 0.1 to 4% by mass, and particularly preferably 0.2 to 2% by mass. If the content of the polysaccharide is 0.01% by mass or more, the gel strength can be prevented from being insufficient, so that the handleability is good, and if it is 5% by mass or less, the liquid component contained in the hydrogel exudes. For example, it is possible to prevent a decrease in skin permeability.

<O / W emulsion>
The hydrogel in the present invention preferably contains an O / W emulsion. In particular, an O / W emulsion containing an oil-soluble functional component that can act as a medicinal component or the like is preferable. By setting it as such a form, if the gel sheet of this invention is made into the gel sheet for biological bodies, for example, the skin beautifying effect can be heightened by skin permeation.

  Examples of oil-soluble functional ingredients include fat-soluble vitamins and analogs thereof (tocopherol, tocotrienol, retinol, retinal, calciferol, etc.), sterols (cholesterol, phytosterol, etc.), ubiquinones (CoQ10, etc.), sphingolipids, Ceramide, oryzanol, squalene, squalane, carotenoid and the like, and derivatives thereof are preferred. The oil-soluble functional component applicable to the present invention is particularly preferably carotenoid.

  Examples of carotenoids include actinioerythrol, astaxanthin, bixin, canthaxanthin, capsanthin, β-8′-apo-carotenal, β-12′-apo-carotenal, α-carotene, β-carotene, γ-carotene, β- Examples include cryptoxanthin, lutein, lycopene, biorelythrin, zeaxanthin, fucoxanthin, and derivatives thereof.

  Of these, astaxanthin, lutein, zeaxanthin, and β-cryptoxanthin are preferable as the carotenoid, and in particular, astaxanthin that is recognized to have an antioxidant effect, an anti-inflammatory effect, an anti-skin aging effect, and a whitening effect.

  In addition, in this O / W type | mold emulsion, you may contain other components, such as an emulsifier which can generally be contained in each phase of an emulsion composition, in the quantity generally used. Such other components also include other components described herein such as polyhydric alcohols.

  The volume average particle size of the emulsified particles of the O / W type emulsion is preferably 1 nm to 200 nm, and particularly preferably 1 nm to 150 nm.

  The volume average particle size of the emulsified particles of the O / W emulsion can be measured with a commercially available particle size distribution meter or the like. Emulsion particle size measurement methods include optical microscopy, confocal laser microscopy, electron microscopy, atomic force microscopy, static light scattering, laser diffraction, dynamic light scattering, centrifugal sedimentation, electricity A pulse measurement method, a chromatography method, an ultrasonic attenuation method, and the like are known, and apparatuses corresponding to the respective principles are commercially available.

  In view of the volume average particle size range and ease of measurement, the dynamic light scattering method is preferably used for measuring the volume average particle size of the emulsion in the present invention. As a commercially available measuring device using dynamic light scattering, Nanotrac UPA (Nikkiso Co., Ltd.), dynamic light scattering type particle size distribution measuring device LB-550 (Horiba, Ltd.), a concentrated particle size analyzer FPAR-1000 (Otsuka Electronics Co., Ltd.) etc. are mentioned.

  In the present invention, the volume average particle size of the O / W emulsion employs a value measured at 25 ° C. using a concentrated particle size analyzer FPAR-1000 (manufactured by Otsuka Electronics Co., Ltd.).

  The volume average particle size is measured by using a measuring glass tube after diluting with pure water so that the concentration of the oil phase component is in the range of 0.1 to 1% by mass. The volume average particle diameter is obtained as a cumulative (50%) value when measured by setting the dispersion medium refractive index to 1.3313 (pure water) and the dispersion medium viscosity to 0.8846 mPa · s (pure water). Can do.

  The method for producing the O / W emulsion is not particularly limited, and for example, a method described in JP-A-2005-75817 can be used. Alternatively, a) a water-soluble emulsifier is dissolved in an aqueous medium to obtain an aqueous phase, b) carotenoid, tocopherol, lecithin, and other oils and fats as necessary are mixed and dissolved to obtain an oil phase, and c) stirring The aqueous phase and the oil phase are preferably mixed together under emulsification and dispersion to obtain an emulsion composition.

  When emulsifying and dispersing, for example, after emulsification using a normal emulsifier using a shearing action such as stirring with a stirrer, impeller, homomixer, continuous flow type shearing device, etc., two methods are used such as passing through a high-pressure homogenizer. It is particularly preferable to use the above emulsifying apparatus in combination. By using a high-pressure homogenizer, it is possible to align the emulsion into more uniform droplets of fine particles.

  The content of the O / W emulsion contained in the hydrogel is preferably 0.001 to 10% by mass in terms of the efficacy of the functional component and the skin permeability when applied to the biomedical sheet. It is more preferable that it is 0.05-1 mass%.

  Moreover, although content of the oil-soluble functional component contained in hydrogel changes with functional components, 0.0001-10 mass% is preferable and 0.005-5 mass% is more preferable.

  When the oil-soluble functional component is carotenoid, the content of carotenoid in the hydrogel is preferably 0.0001 to 0.5% by mass, and 0.0005 to 0.1% by mass. More preferably, it is 0.001-0.05 mass% especially preferable. If the carotenoid content is 0.0001% by mass or more, when the gel sheet of the present invention is used as a living body gel sheet, an effect after applying the gel sheet to the skin (beautifying skin effect, etc.) is felt. If it is 0.5 mass% or less, coloring to an epidermis can be suppressed and it is hard to produce discomfort.

<Collagen or its degradation product>
The hydrogel in the present invention preferably contains at least one selected from collagen or a degradation product thereof. Collagen or a degradation product thereof can improve moisture retention when a gel sheet is attached to an adherend.

  Collagen here is not particularly limited, and various collagen extracts are targeted. Extraction can be performed using a collagen-containing raw material by known techniques such as acid solubilization, alkali solubilization, neutral salt solubilization, enzyme solubilization, and the like. As the collagen-containing material, any material containing collagen can be used, and examples include vertebrate (eg, cow, pig, sardine, shark, etc.) skin or scales, bones, cartilage, tendons, and organs. The Since the collagen content is high, bone, cartilage, skin or scale, tendon, placenta and the like are preferably used as the collagen content raw material. Of these, water-soluble collagen is preferred as the collagen that can be suitably used in the present invention.

  The collagen degradation product can be obtained by hydrolyzing collagen with a proteolytic enzyme such as collagenase, trypsin or chymotrypsin, acid or alkali, or by heat denaturation. Examples of the collagen degradation product include acid-treated gelatin, alkali-treated gelatin, enzyme-degraded gelatin, collagen tripeptide, collagen dipeptide, and amino acid (glycine, proline, hydroxyproline, acetylhydroxyproline, etc.).

  The content of collagen or collagen degradation product in the hydrogel is preferably 0.05 to 20% by mass, more preferably 0.1 to 10% by mass, and particularly preferably 0.2 to 5% by mass. If the content of collagen or collagen degradation product is 0.05% by mass or more, a water retention effect can be obtained when the gel sheet of the present invention is applied to an epidermis or the like for a living body, and 20% by mass or less. The gel sheet is easy to handle.

<Polyhydric alcohol compound>
The hydrogel in the present invention preferably contains a polyhydric alcohol compound. The polyhydric alcohol compound can improve the skin permeability of the functional component and the storage stability of the gel sheet when the gel sheet is applied to a living body.

  Specific examples of the polyhydric alcohol compound include glycerins (glycerin, diglycerin, etc.), glycols (for example, diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, 1,2-propanediol, 1,3 -Propanediol, dipropylene glycol, 1,2-butanediol, 1,3-butanediol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, etc., sugars (glucose, fructose) , Mannose, galactose, xylose, arabinose, glucosamine, N-acetylglucosamine, sucrose, lactose, maltose, isomaltose, trehalose, cellobiose, cordobiose, sophorose, maltotriose, la Inosu, etc. stachyose), sugar alcohols (glycerol, tray roll, erythritol, arabinitol, xylitol, ribitol, mannitol, sorbitol, galactitol, inositol, etc.). The said polyhydric alcohol compound can be used individually or in mixture of 2 or more types.

  Of these, the polyhydric alcohol compounds are preferably glycerins or glycols, among which glycerin, 1,2-propanediol, 1,2-butanediol, 1,2-pentanediol, 1,2 -Hexanediol and 1,3-butanediol are more preferred. Further, glycerol, 1,2-propanediol, 1,3-butanediol, and 1,2-hexanediol are particularly preferable.

  The content of the polyhydric alcohol compound in the hydrogel is preferably 50% by mass or less, and particularly preferably 1 to 20% by mass.

  By making the ratio of the polyhydric alcohol compound in the hydrogel in the present invention 50% by mass or less, it is possible to prevent the gel strength from being lowered and improve the handleability.

<Water-soluble divalent metal salt>
The hydrogel in the gel sheet of the present invention preferably contains a water-soluble divalent metal salt. Here, the water-soluble in the present invention refers to a substance that can be dissolved in pure water at 25 ° C. by at least 0.1 mass%.

Examples of the divalent metal forming the water-soluble divalent metal salt used in the present invention include Group II magnesium, calcium, strontium, barium, transition metals Cu ²⁺ , Fe ²⁺ , Zn ²⁺ and Mn ^2+. Magnesium and calcium are more preferred. The water-soluble salt may be any of an inorganic salt, an organic acid salt, and an organic / inorganic composite salt, and is not particularly limited. For example, hydrochloride, nitrate, sulfate, phosphate, carbonate, citrate, lactate, malate, succinate, ascorbate, ascorbate phosphate, gluconate, etc. .
Among these, specifically, magnesium chloride, calcium chloride, magnesium lactate, magnesium malate, magnesium citrate, calcium citrate, magnesium ascorbate, calcium ascorbate, magnesium ascorbate phosphate, magnesium gluconate, glucone Calcium acid is more preferable, and magnesium chloride and magnesium ascorbate phosphate are particularly preferable.

  The water-soluble divalent metal salt is preferably contained in the hydrogel-forming liquid mixture in an amount of 0.1 to 5% by mass, more preferably 0.2 to 4% by mass, and 0.5 to 2% by mass. % Is particularly preferable.

  In addition, the water-soluble divalent metal salt is preferably blended in an amount of 50 parts by mass or more based on 100 parts by mass of the anionic polymer compound used in combination in the hydrogel-forming liquid. From the viewpoint of the addition effect, 50 parts by mass to 1000 parts by mass are more preferable, 70 parts by mass to 500 parts by mass are further preferable, and 80 parts by mass to 300 parts by mass are particularly preferable. By using this anionic polymer in combination with a divalent metal water-soluble salt, a three-dimensional network structure having a weak cross-linked structure is formed in the formed hydrogel system, and sufficient liquid component retention and good separation are achieved. It is thought that serousness develops.

The anionic polymer compound includes an anionic polysaccharide in the above-mentioned polysaccharide and an anion selected from a carboxyl group, a sulfo group, a phospho group, etc. as a hydrophilic group in the hydrophilic polymer compound described later. This corresponds to a polymer compound having a functional group in the molecule.
For example, anionic synthetic polymer compounds include acrylic acid (co) polymer, methacrylic acid (co) polymer, maleic acid (co) polymer, itaconic acid (co) polymer, p-vinylbenzoic acid (co-polymer). ) Polymer, 2-acrylamido-2-methyl-1-propanesulfonic acid (co) polymer, and styrenesulfonic acid (co) polymer.
Examples of anionic natural polymer compounds include pectic acid, alginic acid, agar, carrageenan, fucoidan, hyaluronic acid, chondroitin sulfate, heparin, gellan gum, native gellan gum, xanthan gum, carboxymethylcellulose, carboxymethyl starch, carboxymethyldextran, and polyglutamic acid. Furthermore, DNA, RNA, and the like can also be used as the anionic polymer in the present invention.

Of these, acrylic acid (co) polymer, alginic acid, agar, carrageenan, hyaluronic acid, gellan gum, native gellan gum, xanthan gum and carboxymethylcellulose are preferred from the viewpoint of water retention, gel strength and release properties, and agar and carrageenan. Gellan gum, native gellan gum, and xanthan gum are particularly preferred.
From the viewpoint of improving the gel strength, the molecular weight of the anionic polymer compound is preferably in the range of 10,000 to 5,000,000, and more preferably in the range of 20,000 to 2,000,000.

  When the water-soluble divalent metal salt and the anionic polymer compound are used in combination, the content of the anionic polymer compound in the hydrogel is preferably 0.01 to 10% by mass, and 0.1 to 8% by mass. % Is more preferable, and 0.2 to 4% by mass is particularly preferable. When the content is in this range, it is possible to achieve gel strength with good handleability and to obtain a hydrogel having sufficient release properties.

  The anionic polymer compound and the water-soluble divalent metal salt can be appropriately combined depending on the purpose, but from the viewpoint of achieving both gel strength and release properties, water-soluble 2 as shown below. Although the combination of a valent metal salt / anionic polymer compound is mentioned as a suitable thing, it is not restrict | limited to these.

Ascorbic acid phosphate magnesium / carrageenan,
Magnesium ascorbate phosphate / gellan gum,
Ascorbic acid phosphate magnesium / agar,
Ascorbic acid phosphate magnesium / xanthan gum,
Ascorbic acid phosphate magnesium / acrylic acid (co) polymer,
Ascorbic acid phosphate magnesium / carboxymethylcellulose,
Magnesium chloride / carrageenan,
Magnesium chloride / gellan gum,
Magnesium chloride / acrylic acid (co) polymer,
Magnesium lactate / carrageenan,
Magnesium lactate / agar calcium lactate / gellan gum calcium ascorbate / carrageenan calcium gluconate / gellan gum.

  Further, the content of the water-soluble divalent metal salt in the formed hydrogel is preferably 0.1 to 5% by mass, more preferably 0.2 to 4% by mass, and particularly preferably 0.5 to 2% by mass. preferable. When the ratio of the water-soluble metal salt is within this range, it is possible to obtain a gel sheet that improves separation from the hydrogel and is excellent in handling.

  In a hydrogel formed of an anionic polymer and a water-soluble divalent metal salt, the water-soluble divalent metal salt does not necessarily exist in a “salt” state. However, the content of the water-soluble divalent metal salt or the compound derived therefrom in the formed hydrogel can be converted from the amount by measuring the amount of the metal constituting the metal salt. Therefore, the “content of the water-soluble divalent metal salt in the hydrogel” refers to the value converted in this way. According to this method, even if it is a hydrogel after formation, it can be detected whether the water-soluble divalent metal salt included in the hydrogel is within the above-mentioned content range.

<Other ingredients>
The hydrogel in the gel sheet of the present invention contains, in addition to the above components, other components such as hydrophilic polymer compounds, excipients, preservatives, and fragrances depending on various effects required for the gel sheet. Is preferred.

-Hydrophilic polymer compounds-
A known hydrophilic polymer compound can be added to the hydrogel in the present invention. From the standpoint of improving the moisture retention of the adherend, the hydrophilic polymer compound can be added to the hydrogel as long as the solubility upon contact with the adherend such as the skin is not impaired. . The hydrophilic polymer compound can also be used for improving the shape stability of the gel sheet.

  The hydrophilic polymer compound that can be used in the present invention is a polymer compound other than the polyether and the polysaccharide, and has a hydrophilic functional group (for example, hydroxyl group, carboxyl group, sulfo group, phospho group, carbamoyl). Group, amino group, ammonio group, ethyleneoxy group, etc.) may be a synthetic polymer compound or a natural polymer compound. These may be used alone or in admixture of two or more.

  Suitable synthetic polymer compounds having a hydrophilic group for the present invention include, for example, vinyl alcohol (co) polymer, 2-hydroxyethyl acrylate (co) polymer, acrylic acid (co) polymer, methacrylic acid ( Co) polymer, maleic acid (co) polymer, itaconic acid (co) polymer, p-vinylbenzoic acid (co) polymer, 2-acrylamido-2-methyl-1-propanesulfonic acid (co) polymer Styrene sulfonic acid (co) polymer, acrylamide (co) polymer, acryloylmorpholine (co) polymer, N-vinylpyrrolidone (co) polymer, vinylamine (co) polymer, N, N-dimethyldiallylammonium chloride (Co) polymer, 2-methacryloyloxyethylammonium chloride (co) polymer, polyethylene glycol methacrylate (co) polymer Polyethyleneimine, and the like.

  The hydrophilic polymer compound in the present invention preferably has a weight average molecular weight of 1,000 to 500,000, preferably 5,000 to 100,000, from the viewpoint of improving the moisture retention of the adherend. More preferred.

  The content of the hydrophilic polymer compound in the hydrogel is preferably 0.05 to 5% by mass, preferably 0.1 to 3% by mass, from the viewpoint of improving the moisture retention of the adherend and the handleability of the gel sheet. More preferably.

-Excipient-
In the hydrogel in the present invention, it is preferable to add an excipient to the hydrogel in order to further improve the shape stability. As the excipient, organic or inorganic fine particles can be preferably used. As the organic fine particles, known polystyrene particles, polymethacrylate particles, and microcrystalline cellulose are preferable. As the inorganic fine particles, titanium oxide, silica, alumina, calcium carbonate, kaolin, clay mineral, and the like are preferable. Of these, silica or clay minerals are preferable, and gas phase method silica having an average particle diameter of 200 nm or less and synthetic smectite are particularly preferable.

  The proportion of the excipient in the hydrogel in the present invention is preferably 10% by mass or less, and particularly preferably 1 to 5% by mass.

-Preservative-
The hydrogel in the present invention preferably contains a preservative. By including a preservative, it is possible to prevent alteration of the hydrogel caused by microorganisms.

  Examples of the preservative include phenol, benzoic acid and its salt, salicylic acid and its salt, paraoxybenzoic acid esters (methylparaben, ethylparaben, propylparaben, butylparaben), 2-phenoxyethanol, dehydroacetic acid and its salt, sorbic acid and Examples thereof include salts thereof, alkylaminoethylglycine chloride, triclosan, benzalkonium chloride, ethanol, propanol, and butanol. These may be used alone or more preferably in combination. Of these, paraoxybenzoates and phenoxyethanol are particularly preferred.

  As content of the antiseptic | preservative in hydrogel, 0.01-0.5 mass% is preferable, 0.02-0.3 mass% is more preferable, 0.03-0.2 mass% is especially preferable.

-Fragrance-
A fragrance | flavor may be added to the hydrogel in this invention. A relaxation effect etc. can be heightened by adding a fragrance | flavor to hydrogel.

  Examples of the fragrances include alcohol-based fragrances, phenol-based fragrances, carboxylic acid-based fragrances, amine-based fragrances, etc., and alcohol-based fragrances include green leaf alcohol, 3-octenol, 9-decenol, linalool, geraniol, nerol, citronellol, Rosinol, dimethyloctanol, hydroxycitronellol, tetrahydrolinalol, labanguol, mugole, misenol, terpineol, 1-menthol (L-menthol), borneol, isobregor, tetrahydromugor, bornylmethoxycyclohexanol, nobol, farnesol, nerolidol , Santalol, sandalol, cedrol, vetiverol, patchouli alcohol, benzyl alcohol, β-phenylethyl alcohol, γ-phenylpropyl Alcohol, cinnamic alcohol, anis alcohol, α-amyl cinnamic alcohol, dimethyl benzyl carbinol, methyl phenyl carbinol, dimethyl phenyl carbinol, β-phenyl ethyl dimethyl carbinol, β-phenyl ethyl methyl ethyl carbinol, phenoxy ethyl Alcohol, phenyl glycol, tertiary butyl cyclohexanol, etc. are mentioned. Further, eugenol, vanillin, hinokitiol, etc. as phenolic fragrances, cinnamic acid, phenylacetic acid, hydrocinnamic acid, etc. as carboxylic acid fragrances, and indole, skatole, 2-methyltetrahydroquinoline as amine-based fragrances. , 6-methylquinoline and the like.

-Organic acid-
The hydrogel may further contain an organic acid from the viewpoint of pH adjustment. Specific examples of the organic acid salt include acetic acid, α-hydroxy acid (for example, citric acid, lactic acid, gluconic acid, malic acid, succinic acid, etc.), ascorbic acid, pyrrolidone carboxylic acid, and the like. These can be used alone or in admixture of two or more. The content of these organic acids in the hydrogel is preferably 0.01 to 5% by mass, and more preferably 0.05 to 2% by mass.

-Other additives-
Depending on the intended use of the gel sheet of the present invention, various active ingredients and additives can be further blended. Examples of such active ingredients and additives include those shown below.

Antioxidants: Tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters and the like.
UV absorbers: p-methoxycinnamic acid, octyl p-methoxycinnamate, 2-methoxy-2-hydroxybenzophenone, p-dimethylaminobenzoic acid-2-ethylhexyl, and the like.
PH adjuster: Buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, succinic acid-sodium succinate, and the like.
Chelating agent: phytic acid, ethylenediaminetetraacetic acid, etc.
-Surfactant: Polyglycerin fatty acid ester, sucrose fatty acid ester, lecithin and the like.
Vitamin: Vitamin A, B1, B2, B6, C, D, E and derivatives thereof.
Amino acids: Glycine, trimethylglycine, pyrrolidone carboxylic acid, serine, carnitine, γ-aminobutyric acid, taurine, threonine, asparagine, glutamine, tyrosine, lysine, histidine, arginine, aspartic acid, glutamic acid, ornithine, valine, leucine and the like.

Anti-inflammatory agents: glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin, etc.
-Moisturizer: urea, casein, soybean peptide, lactic acid bacteria fermentation metabolite, yeast fermentation metabolite, honey, lactoferrin, albumin, hydrolyzed elastin, hydrolyzed keratin, hydrolyzed silk.
-Whitening agents: ascorbic acid glucoside, 3-O-ethylascorbic acid, arbutin, hydroquinone, kojic acid, lucinol, tranexamic acid, adenosine-1-phosphate sodium, magnolignan, ellagic acid, retinoid, rutin, resorcinol, cysteine, Glutathione and the like.

・ Various extracts: For example, Ashitaba extract, Avocado extract, Achacha extract, Altea extract, Arnica extract, Aloe extract, Apricot extract, Apricot extract, Ginkgo biloba extract, Fennel extract, Turmeric extract, Oolong tea extract, Ages extract, Echinashi leaf extract , Ogon extract, Oat extract, Auren extract, Barley extract, Hypericum extract, Odrianthus extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Chamomile extract, Carrot Extract, Kawaramugi Extract, Licorice Extract, Calcade Extract, Oyster Extract, Kiwi Extract, Kina Extract, Cucumber Extract, Guanosine, Gardenia Extract, Kumazasa Extract, Clara Echi , Walnut extract, grapefruit extract, clematis extract, chlorella extract, mulberry extract, gentian extract, tea extract, yeast extract, burdock extract, rice bran ferment extract, rice germ oil, comfrey extract, bilberry extract, saicin extract, psycho extract, saitai extract Liquid, Salvia extract, Soap extract, Sasa extract, Hawthorn extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimotake extract, Peonies extract, Ginger root extract, Birch extract, Japanese cedar extract, Pepper extract, Hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, sensu extract Japanese amber extract, soybean extract, peanut extract, thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, toki extract, eucalyptus extract, tonin extract, spruce extract, dodami extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus Extract, Bacmond Extract, Parsley Extract, Honey, Clamellis Extract, Parietalia Extract, Buttercup Extract, Bisabolol, Biwa Extract, Bukit Dandelion Extract, Fukinotou Extract, Bukkuri Extract, Butcher Bloom Extract, Grape Extract, Propolis, Loofah Extract, Safflower Extract, Peppermint extract, Bodaiju extract, button extract, hop extract, pine extract, marronnier extract, citrus extract, mukuro Extract, Melissa extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, yokuinin extract, mugwort extract, lavender extract, apple extract, lettuce extract, lemon extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, Royal jelly extract, birch extract, iris extract, grape extract, lily extract, saffron extract, pepper extract, pepper extract, toki extract, seaweed extract, placenta extract, placenta extract, chamomile extract, pearl seed extract, coconut seed extract, grape seed Extracts, watercress extract, moonlight beauty extract, white lupine extract, ginger extract, chicken crown extract, etc.

Activator: For example, royal jelly, photosensitizer, cholesterol derivative and the like.
-Blood circulation promoter: For example, nonyl acid valenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, gingerone, cantalis tincture, ectamol, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicotinate, Cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol and the like.
Anti-seborrheic agent: For example, sulfur, thianthol and the like.
-Anti-inflammatory agents: for example, tranexamic acid, thiotaurine, hypotaurine, etc.).

  These active ingredients can be used alone or in combination of two or more according to the purpose of use of the gel sheet. In addition to these, in the case of application to a conventionally known humectant or biogel sheet, a medicinal component can be added as long as it can be administered into the living body through skin permeation.

-Preferred embodiment of hydrogel-
As long as the gel sheet of the present invention exhibits the separation rate, the combination of the above components for producing the hydrogel is not particularly limited. The combination is preferably a case where at least a polysaccharide, collagen or a collagen degradation product, a water-soluble divalent metal, a polyhydric alcohol compound and water are used, and more preferably, two or more polysaccharides, a collagen degradation product, a magnesium salt In this case, at least a polyhydric alcohol compound and water are used.
When the gel sheet of the present invention is applied as a cosmetic, it is preferable that the hydrogel further contains an O / W emulsion or collagen in addition to the combination of the above components.

For example, the following method can be mentioned as a method for adjusting the separation rate of the hydrogel of the present invention. However, it is not limited to the following method.
That is, in order to increase the separation rate, the amount of addition of polyether, water-soluble divalent metal, polyhydric alcohol, etc. is increased, polyether and collagen or its degradable organisms are used in combination, or water-soluble 2 Formulations such as using a combination of a valent metal salt and an anionic polysaccharide can be presented. Furthermore, the amount of polysaccharides that can retain moisture in the hydrogel may be reduced to such an extent that the gel structure can be retained.

-Structure of gel sheet-
The gel sheet of the present invention is a sheet-like molded body having a structure in which a support base material and a hydrogel are integrated. Here, the “integrated structure” is a structure in which a layer composed of a hydrogel and a supporting base material are arranged adjacent to each other, and the two are in close contact with each other at a strength that does not peel off during handling of the gel sheet, or It refers to a structure in which all or part of the supporting substrate is inherent in the hydrogel.

The gel sheet of the present invention preferably has a structure in which the sheet-like base material (support base material) is provided in or adjacent to the hydrogel layer containing the hydrogel.
Among these, it is particularly preferable that the gel sheet of the present invention has a structure in which the hydrogel and the woven or non-woven fabric are integrated.

  The gel sheet of the present invention may have a multilayer structure having other layers (for example, a protective sheet) as long as it has a structure in which the support base and the hydrogel are integrated. Moreover, the aspect which provided multiple layers of hydrogel layers from which a structure differs may be sufficient. When the gel sheet of the present invention is constituted by a plurality of hydrogel layers, each of the above-described components that may be contained in the hydrogel may be contained in the same hydrogel layer, and contained in a plurality of layers. Also good. When the gel sheet of this invention is comprised from a some hydrogel layer, content of each above described component is the quantity contained in the whole layer of the hydrogel layer which comprises a gel sheet.

  As the support substrate, a known sheet-like support substrate such as a nonwoven fabric, a woven fabric, a film, or a gel can be used.

  There is no restriction | limiting in particular as a raw material which comprises a nonwoven fabric and a woven fabric, As a fiber, what is generally used can be used. Examples thereof include natural fibers such as cellulose, rayon and fibroin, and synthetic fibers such as nylon, polyester, polyethylene, polypropylene, acrylic resin, polylactic acid and polyurethane, and cellulose, nylon, polyester and polyurethane are preferably used.

  In the case of using a film, the material is arbitrary, and examples thereof include a liquid-impermeable single layer or a multilayer plastic sheet. In addition, a sheet in which an opening for liquid permeation is formed over a part or the entire surface of the sheet, a porous sheet, a mesh sheet, or the like can be used.

  The thickness of the supporting substrate is preferably about 0.01 mm to 1 mm from the viewpoint of handling properties. Moreover, when using for cosmetics etc., it may be preferable to use a thing with high transparency so that it may explain in full detail below.

  When the support substrate is provided in the hydrogel layer, a liquid-permeable sheet, for example, a woven fabric, a nonwoven fabric, a porous sheet, or a mesh is preferred. A permeable sheet, a thick woven fabric, a non-woven fabric, or the like can be used.

  When the supporting substrate is used as a reinforcing layer for the hydrogel layer, a crosslinked gel (gelatin / glutaraldehyde crosslinked gel, polyacrylic acid / polyvalent metal ion crosslinked gel, etc.), physical gel (agarose gel, κ-carrageenan). Gel), and further, a base material such as a polymer gel sheet having high breaking strength such as a water-insoluble film (chitosan film, cellophane, κ-carrageenan cast film, etc.) formed from a hydrophilic polymer, or a hydrophilic polymer film. It is also possible to use it.

Of these, the support substrate is preferably a woven fabric or a non-woven fabric. The basis weight of the woven or nonwoven fabric is ^preferably in the range of ^{3g / m 2 ~100g / m 2} , more preferably ^{5g / m 2 ~70g / m 2} , 5g / m 2 ~50g / and particularly preferably m ^2. When the weight per unit area is in the above range, the strength of the supporting base material is in a range where the handling property is excellent, the flexibility of the gel sheet is not impaired, and the adhesion at the time of sticking does not decrease.

  The gel sheet of the present invention is preferably provided with a protective sheet for the purpose of maintaining retention of active ingredients and moisture until use. As the protective sheet, it is preferable to use a polyethylene film, a polypropylene film, a PET film or the like. Among them, it is preferable to use a polyethylene film having a thickness of 500 μm or less, more preferably 20 μm to 400 μm.

  In general, the thickness of the gel sheet of the present invention is preferably from 0.4 mm to 2 mm, particularly preferably from 0.5 mm to 1.5 mm, from the viewpoint of shape retention and handleability.

-Method for producing gel sheet-
The manufacturing method of the gel sheet of this invention can be manufactured in accordance with the method generally performed.

  For example, each component constituting the hydrogel is heated and mixed to prepare a hydrogel-forming liquid mixture, and the liquid mixture is applied on a sheet-like support base, or a sheet-like liquid is formed in the liquid mixture After immersing the supporting base material, the gel sheet can be easily obtained by forming a hydrogel layer by allowing it to stand in a normal temperature atmosphere or cooling it. Alternatively, after the hydrogel is applied in a sheet form, it can be obtained by laminating a sheet-like support base material before the gelation is completed.

  Moreover, what is necessary is just to coat | cover with a protection sheet so that the part which the hydrogel in the gel sheet has exposed may be provided when providing a protection sheet.

  The active ingredients such as the polyhydric alcohol, O / W emulsion and polysaccharide may be added separately or together during the production process of the hydrogel, or the active ingredients may be added after the production of the hydrogel. It is also possible to introduce the hydrogel by impregnating it with the hydrogel for about 1 to 3 days.

-Physical properties of gel sheet-
It is preferable that the gel sheet of the present invention has high transparency from the viewpoint of reducing an unpleasant appearance when attached to the skin.

  The transparency of the gel sheet of the present invention can be evaluated by the character discrimination size through the gel sheet using a spectrophotometer. In the gel sheet of the present invention, it is preferable to be able to discriminate a 12-point size character in the Mincho style, and more preferably to be able to discriminate a 10-point size character. By being in this range, for example, in the case of a biogel sheet, it becomes easy to check the state of the skin at the time of application. However, it is not always necessary to be transparent when applied to a use site where the appearance is not considered.

  Further, when the gel sheet requires transparency, it is preferable to select a support base material used together with the hydrogel that is excellent in light transmittance such as a nylon woven fabric having a small basis weight and a transparent resin film. .

-Shape of gel sheet-
Although there is no restriction | limiting in particular as a shape at the time of providing the gel sheet of this invention for practical use, The shape wound by tape shape and the roll shape may be provided, and the sheet | seat which became independent one by one may be sufficient. In the case of individual sheets, the shape thereof is arbitrary, and is appropriately selected according to the purpose of use and the use site, for example, oval, circular, heart-shaped, semi-circular, semi-elliptical, square, rectangular, trapezoidal, triangular, Or the shape etc. which combined these are mentioned, You may design suitably the shape which can be affixed most appropriately with the shape along an application site | part, and a use site | part.
For example, when used as a living body pressure-sensitive adhesive sheet, a convex portion or a concave portion is provided for the purpose of alignment or the like at the center or peripheral portion of the gel sheet, or a cut or cut-out portion is provided depending on the shape of the use site. An aspect can be taken, and by taking such an aspect, the handleability of the adhesive sheet in an application site | part can be improved, and the adhesiveness with the adjacent to-be-adhered body in a required area | region can be improved.

Hereinafter, the application site | part and shape of the gel sheet of this invention are demonstrated.
The application site when the gel sheet of the present invention is applied to a living body includes the face (lips, cheeks, eyes, upper and lower parts of the eyes, nose, forehead, entire face), arms, legs, chest, and abdomen. , Back, neck and the like.

When the gel sheet of the present invention is used as a biogel sheet, not only the shape described above, but also the area, thickness, adhesive property of the outermost surface of the hydrogel layer, and the like may be appropriately adjusted according to the application site. Moreover, the kind and content of the active ingredient to contain can also be adjusted suitably.
For example, when forming a biomedical sheet in which the application site is the entire face, the portion corresponding to the position of the eyes and mouth is cut out, and the portion corresponding to the position of the nose is cut, and the pasting area is large Therefore, it is preferable to make adjustments such as increasing the adhesive strength of the adhesive layer or reducing the thickness. Further, the face shape may be divided into two parts, and divided into an upper part applied around the forehead, eyes and nose, and a lower part applied around the mouth to the chin part.

These gel sheets may be hermetically sealed in a packaging material made of a non-breathable material in order to prevent moisture and active ingredients from decreasing with time before use.
For example, in the case of a gel sheet continuous in a tape shape, it can be stored in an openable / closable sealed container, such as a packaging bag made of a non-breathable sheet with a chuck, a lidded container formed of a non-breathable resin, or the like. In the case of individual sheets that are independent of each other, they may be sealed in an openable individual bag made of a non-breathable sheet. By storing and distributing in such a state, moisture and active ingredients can be maintained in an appropriate state until use.

  The gel sheet of the present invention configured as described above has excellent adhesion to the living body, moisture retention, effective release of the active ingredient, and good handleability, so the types of ingredients to be included in the hydrogel layer By selecting the amount, amount, hydrogel layer thickness, and gel sheet dosage form, it can be used for patches, cosmetics, facial treatments, skin treatments, etc. It is useful for sheet-like cosmetics such as packs, carriers for active ingredients such as skin penetration components and anti-inflammatory analgesic components, bioadhesive tapes for wound protection and drug immobilization, wound dressings and the like.

[Sheet cosmetic]
The sheet cosmetic of the present invention is configured using the gel sheet of the present invention.
That is, the gel sheet of the present invention can be made into a cosmetic by holding a moisturizing component, a whitening component, an astringent component, etc. as functional components (active ingredients). This sheet-shaped cosmetic is used with the surface of the hydrogel layer in close contact with the skin.
Since the gel sheet of the present invention is excellent in skin penetration and handling of active ingredients and the like, the sheet-like cosmetic of the present invention is a pack that moisturizes and gives medicinal ingredients to the skin as described above. It is particularly useful as a sheet-like cosmetic material such as an agent.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples, but the present invention is not limited thereto. Unless otherwise specified, “part” and “%” represent “part by mass” and “% by mass”, respectively.

[Examples 1 to 5, Comparative Examples 1 to 4]
<Preparation of O / W type emulsion>
The following components were dissolved for 1 hour while heating at 70 ° C. to obtain an aqueous phase composition.
(Water phase component)
・ Sucrose oleate ・ ・ ・ 15g
・ Decaglyceryl monooleate ・ ・ ・ 23g
・ Glycerin ... 500g
・ Pure water ... 322g

Moreover, the following component was melt | dissolved for 1 hour, heating at 70 degreeC, and the oil-phase composition was obtained.
(Oil phase component)
・ Hematococcus alga extract (astaxanthin content 20% by mass) ... 40 g
・ Mixed tocopherol ・ ・ ・ 10g
・ Lecithin (derived from soybean) ... 90g

  The aqueous phase composition was stirred with a homogenizer while maintaining the temperature at 70 ° C. (10000 rpm), and the oil phase composition was added thereto to obtain an emulsion. The obtained emulsion was high-pressure emulsified at 200 MPa using an optimizer HJP-25005 (manufactured by Sugino Machine Co., Ltd.). The volume average particle size of the obtained emulsion was measured at 25 ° C. using a concentrated particle size analyzer FPAR-1000 (manufactured by Otsuka Electronics Co., Ltd.), and found to be 90 nm.

<Production of gel sheet>
Among the components shown in Table 1, components other than the emulsion were sequentially added to water and heated and kneaded at 80 ° C. to obtain a sol-like product. Here, the unit of the component amount shown in Table 1 is “part by mass”.
After the sol-like product was cooled to 60 ° C., the O / W emulsion was added and stirred uniformly. After spreading this with a doctor blade so that the thickness becomes 0.8 mm, it is covered with a nylon knitted fabric with a weight per unit area of 20 g / m ² and allowed to stand at 25 ° C. for 30 minutes. The gel sheets of Examples 1 to 5 and Comparative Examples 1 to 4 provided as base materials and having hydrogel layers on both surfaces thereof were obtained. The total thickness of the hydrogel layer was 0.8 mm.

(Evaluation of gel sheet)
The following evaluation was performed using the gel sheets of Examples 1 to 5 and Comparative Examples 1 to 4, and the evaluation results are also shown in Table 1. In addition, adhesiveness, moisture retention, skin barrier property, and sensory evaluation used the gel sheet of the said Examples 1-5 and Comparative Examples 1-4 for 10 monitors, respectively (applied on a face), and the average of the evaluation The values are shown in Table 1.

(1) Separation rate The gel sheets of Examples 1 to 5 and Comparative Examples 1 to 4 were cut into 3 cm x 3 cm to prepare a sample, and this sample was obtained from Advantech Toyo Co., Ltd. filter paper No. 2 (two types of qualitative filter papers defined in JIS P3801 (1995 edition): 125 g / m ² , thickness 0.26 mm, drainage time 80 seconds, water absorption 80 cm) The change in filter paper mass is measured after standing for 10 minutes in an environment of 50 ° C. and 10% relative humidity. Using the obtained measured value, the separation rate was calculated by the following formula (1).
Separation rate (mass%) = (filter paper absorption mass / gel initial mass * 100) (Equation 1)
Here, the “gel initial mass” was obtained by excluding the mass of the nylon mesh as the sheet base material from the mass of the gel sheet sample piece.
As for the rate of separation, the average value of the values obtained by repeating the above measurement test 5 times was evaluated as the rate of separation.

(2) A feeling of adhesion A is the case where the pasted gel sheet adheres along the face surface, B is the case where partial lifting occurs, and C is the case where many wrinkles are generated in each part. evaluated.
In addition, in stickiness evaluation, when a gel sheet was affixed to the skin, no breakage or undesired stretching was observed, indicating that the gel sheets of Examples 1 to 5 were excellent in handleability.

(3) Moisturizing property The stratum corneum water content of the test site (eye corner part) before 10 gel sheets were attached to the monitor was evaluated by the conductance value in a stratum corneum moisture meter (manufactured by Asahi Biomed).
Thereafter, the gel sheets of Examples 1 to 5 and Comparative Examples 1 to 3 were affixed to the test site for 15 minutes, and after peeling, the stratum corneum moisture content (manufactured by Asahi Biomed Co., Ltd.) was measured 30 minutes later. ) Was evaluated based on the conductance value. Compare the conductance before and after the gel sheet is applied. If the conductance is increased by 15% or more in the average of 10 people, AA is 10% to 15% increase, A is 2% to 10% increase. When B was observed, B was evaluated as C when the change was less than 2%.

(4) Skin barrier property In order to evaluate the rough skin improvement function, transepidermal water transpiration (TEWL) was measured by the following method.
That is, 15 minutes a day was continuously applied for 3 days, and the transepidermal water evaporation (TEWL) immediately after the gel sheet was peeled off on the 3rd day was measured with a water evaporation meter (manufactured by Asahi Biomed). The case where TEWL decreased by 5% by mass or more was evaluated as A, the case of 1-4% by mass as B, and the case where no change was observed as C, compared to before the test.

(5) Sensory evaluation Evaluation was performed based on the impression of the appearance of the skin immediately after the gel sheet was peeled off on the third day when 15 minutes of pasting was continued for 3 days. The case where the texture was clearly felt was indicated as A, the case where the texture was slightly felt was assumed as B, and the case where no change was observed was assumed as C.

(6) Moisture content 1 g of the hydrogel layer was taken out from the gel sheets of Examples 1 to 5 and Comparative Examples 1 to 3, and dried under reduced pressure at 25 ° C. Drying was continued until no change in mass of the sample was observed, and the water content was calculated according to the following formula (2).
Moisture content (%) = (initial mass−mass after drying) / initial mass * 100 (Equation 2)
The average value of the values obtained by repeating the above measurement test 5 times was evaluated as the moisture content.

From the results shown in Table 1, it was revealed that the gel sheets of Examples 1 to 5 had a high rate of detachment, an excellent effect of improving moisture retention and skin barrier properties, and a skin-beautifying effect for adjusting texture. Moreover, the adhesiveness to skin and the handleability when making it contact | adhere to skin were favorable.
From this, it can be seen that the gel sheets 1 to 5 of the examples are gel sheets that can quickly supply the component retained in the hydrogel to a desired region by contact with the skin as the adherend.
On the other hand, in the gel sheets of Comparative Examples 1 to 4 having a low separation rate, the actual feeling in sensory evaluation was not obtained and the moisturizing effect was inferior.

Claims (11)

  A gel sheet having a structure in which a supporting substrate and a hydrogel are integrated and having a separation rate of 40% by mass or more and 90% by mass or less when contacted with a filter paper for 10 minutes.   The gel sheet according to claim 1, wherein the water content of the hydrogel is 70 mass% or more and 95 mass% or less.   The gel sheet according to claim 1, wherein the hydrogel contains a polysaccharide.   The gel sheet according to any one of claims 1 to 3, wherein the hydrogel includes a polyether.   The said hydrogel contains O / W type | mold emulsion, The gel sheet of any one of Claims 1-4 characterized by the above-mentioned.   The said hydrogel contains at least 1 type chosen from collagen or a collagen degradation product, The gel sheet of any one of Claims 1-5 characterized by the above-mentioned.   The gel sheet according to any one of claims 1 to 6, wherein the hydrogel contains a polyhydric alcohol compound.   The gel sheet according to any one of claims 1 to 7, wherein the hydrogel contains a water-soluble divalent metal salt.   The hydrogel layer containing the hydrogel, and the sheet-like support substrate provided in the hydrogel layer or adjacent to the hydrogel layer, The gel sheet according to any one of the above.   The thickness of the said gel sheet is 0.4 mm or more and 2 mm or less, The gel sheet of any one of Claims 1-9 characterized by the above-mentioned.   The sheet-form cosmetics using the gel sheet of any one of Claims 1-10.