JP5430146B2 - Body adhesive sheet - Google Patents

Description

  The present invention relates to a hydrogel sheet used by being attached to the body.

  A water-containing gel sheet made of a water-soluble polymer is used as one means for allowing an active ingredient for cosmetics or medical use to penetrate into the skin. The hydrated gel sheet is particularly applied to uneven parts and movable parts of the body that require flexibility and elasticity derived from the material, and therefore studies have been made on improving adhesiveness and usability.

  For example, a hydrous gel sheet having exudate release properties using two types of water-soluble polymers as a gel base has been proposed (Patent Document 1). Since this gel sheet promotes the adhesion to the target surface by syneresis, no adhesive is required. Moreover, the liquid in a gel sheet is discharge | released in a stationary state, a water | moisture content can be supplied to the skin at the time of sticking, and a moist feeling can be given. However, the liquid layer released at the time of gel formation does not contain a water-soluble polymer having a thickening action and has a very low viscosity. Therefore, the gel layer easily slips on the skin due to the liquid layer, and it is difficult to apply for a long time. Furthermore, gel sheets based on agar or glucomannan are easily plastically deformed, and are easily broken when scratched with nails during use.

  A hydrogel sheet using a polyacrylic acid-based water-soluble polymer as a gel base has been proposed (Patent Document 2). This gel sheet is less susceptible to changes in temperature (deformation) than gelatin-based gel sheets, has high extensibility, is difficult to tear, and is easily elastically deformed. Because it can be protected, it is used in many cosmetics and medical patches. Furthermore, the adhesiveness to the skin is also good. However, since the polyacrylic acid-based water-soluble polymer is a base having high water absorption and water retention, there is a problem in that when it is used in a hydrogel sheet, it cannot provide sufficient moisture to give the skin a moist feeling. there were. Furthermore, the high extensibility becomes a factor of lowering the self-shape retaining property when the sheet is thinned, and means for suppressing the gel extensibility by stacking a woven fabric or a non-woven fabric as a support is required. However, the woven fabric and non-woven fabric used as the support have low extensibility and flexibility compared to the hydrogel layer, and control the flexibility of the hydrogel layer, but on the other hand, the skin with unevenness and movable skin such as elbows and knees. On the other hand, there exists a problem of reducing the followable | trackability as the whole gel sheet.

  Furthermore, a water-containing gel sheet has been proposed in which the release properties and volatilization properties of water from a polyacrylic acid gel are promoted by blending a specific low hydrophilic polyhydric alcohol (Patent Document 3). However, when water is released from within the gel sheet, a liquid layer not containing a thickener is formed on the surface of the gel sheet at the time of application, and the gel sheet becomes slippery on the skin, resulting in a decrease in adhesiveness.

Therefore, as one means for improving the adhesiveness of the gel sheet, a two-layer water-containing gel sheet agent can be mentioned. For example, a technique relating to a two-layered hydrophilic patch in which a water-containing gel layer and a hydrophilic adhesive layer are sequentially laminated on one side of a plastic film through which water vapor permeates has been reported (Patent Document 4). This gel sheet agent is intended to have adhesive strength that does not pass fluid substances such as moisture, but suppresses stuffiness and covering, and does not require auxiliary means such as bandages, and imparts adhesiveness to the adhesive surface side. It has a two-layer structure in which layers are provided. However, there is no specific method for forming an adhesive layer, and there is no idea of actively moisturizing the skin at the site of application or imparting a moist feeling to the peeled skin. In addition, the hydrophilic adhesive layer has, as an adhesive base, polyvinyl pyrrolidone, pullulan, poly (meth) acrylic acid, hydroxypropyl cellulose, methyl vinyl ether / maleic anhydride copolymer, polypropyl (meth) acrylate hydroxypropyl or the same series Uses a copolymer, carboxymethylated dendritic powder, etc. to supply moisture to the skin because it is designed to exhibit low adhesion or to exhibit adhesion with the addition of a plasticizer without moisture Difficult to do. Furthermore, the adhesive base may remain on the skin after peeling, and the adhesive base remaining on the skin is in a state where powder is blown on the skin after drying.
Special table 2003-518008 gazette Japanese Patent Laid-Open No. 60-60854 JP-A-8-188527 JP-A-3-227919

  The problem of the present invention is that the retention property of the moisturizing layer to the hydrous gel layer during storage is high, and has sufficient adhesiveness to the skin during use, followability and extensibility to unevenness and movement of the skin, An object of the present invention is to provide a sheet agent for body sticking that can impart a moist feeling with almost no skin residue or powder blowing due to an adhesive base on the skin after application.

  As a result of various studies to develop a two-layered sheet agent comprising a hydrogel layer as a support and a gel layer for supplying active ingredients and water to the skin, the present inventor has obtained an anionic polymer as the hydrogel layer. If a cross-linked structure is used and an aqueous solution containing a certain amount of hyaluronic acid as a moisturizing layer is placed on the hydrogel layer and laminated, a two-layered sheet agent can be easily obtained. The layer has high adhesion to the skin and has good followability to the unevenness and movement of the skin. When peeling after use, part of the moisturizing layer is transferred onto the skin, and the water in the moisturizing layer and It has been found that hyaluronic acids can be supplied to the skin and there is no skin residue like powder blowing after peeling and drying.

  That is, the present invention provides a body patch having a structure in which (A) a hydrous gel layer containing a crosslinked structure of an anionic polymer and (B) a moisturizing layer, a part of which is transferred onto the skin at the time of sticking. A gel-like layer, wherein the moisturizing layer contains 1.5 to 5% by mass of one or more hyaluronic acids selected from hyaluronic acid, hyaluronic acid decomposition products, hyaluronic acid derivatives and salts thereof And the sheet agent for body sticking obtained by laminating | stacking the aqueous solution containing 1-5 mass% of this hyaluronic acid and this (A) hydrous gel layer is provided.

The sheet for body sticking of the present invention has a high retention property of the moisture retaining layer to the water-containing gel layer during storage and has a gel-like moisture retaining layer on the pasting surface, and thus has good adhesion to the skin. In addition, since the moisture content of the gel-like moisturizing layer is large, moisture is supplied from the moisturizing layer to the skin during application, and a moist feeling can be imparted to the peeled skin. Furthermore, since the water-containing gel layer holding a large amount of water is laminated on the moisturizing layer, the moisture supply to the skin is continued through the moisturizing layer.
In addition, the stratum corneum swells by supplying moisture to the skin, and hyaluronic acids contained in the moisturizing layer easily penetrate into the skin due to the occlusion effect of the hydrated gel layer.
Furthermore, after peeling, a gel-like moisturizing layer containing moisture and hyaluronic acid remains on the skin as a “beauty liquid”. By applying the remaining moisturizing layer on the skin, more hyaluronic acid is supplied to the skin. In addition, the moisturizing layer remains locally, and skin residue such as powder blowing can be prevented.

  The sheet for body patch of the present invention includes a hydrogel layer (A) containing a crosslinked structure of an anionic polymer, and a gel laminated on one side of the hydrogel layer, and a part of the gel is transferred onto the skin when applied. It has a two-layer structure with a moisturizing layer (B).

  The water-containing gel layer (A) is a layer in which a water-containing gel is formed by a crosslinked structure of an anionic polymer, can serve as a support for a sheet agent, and serves as a moisture supply layer and a skin occlusion layer for the gel layer. It has the function of. The crosslinked structure of the anionic polymer forms a dense network structure that becomes a basic skeleton of the hydrogel layer by chemically reacting the anionic polymer with the crosslinking agent by the anionic polymer, the crosslinking agent, and water. ing. A water-containing gel layer formed by chemically cross-linking an anionic polymer is water-insoluble, but it retains a large amount of water in the network structure and swells, so it has moderate elasticity, extensibility, and flexibility. Have. In addition, chemically crosslinked water-containing gels are less thermoplastic than agar gels and so on, so they have stable shape retention over a wide range of operating temperatures, and are extremely useful as a support for body patch sheets. Useful for.

  As the thickness of the water-containing gel layer of the sheet agent of the present invention, it has the retention performance of the moisture retention layer to be laminated, and can maintain the moisture supply to the moisture retention layer. In consideration of the balance between being flexible and being easily peeled off by its own weight, the thickness is preferably 0.5 to 5 mm, more preferably 0.8 to 2 mm.

Further, the gel strength of the hydrous gel layer is preferably 1 to 18 N / cm ² , and more preferably 1.5 to 10 N / cm ² , from the function as a support having appropriate elasticity, extensibility, and flexibility. In particular, ² to 8 N / cm ² is preferable. Here, the gel strength can be measured by the following method.
The hydrogel before completion of the crosslinking reaction is filled into a cup container having a diameter of 60 mmφ and a depth of 80 mm, and the crosslinking reaction is terminated as it is to prepare a cylindrical gel having a diameter of 60 mmφ × height of 60 mm. A plunger (diameter: 12 mmφ, flat type) connected to a digital force gauge is brought into contact with the center of the upper surface of the cylindrical gel in the cup container, and the plunger is pushed into the gel by 30 mm at a constant speed of 300 mm / min. F [N] is measured with a digital force gauge. When the area of the plunger end face is S [cm ² ], the gel strength is calculated by F / S [N / cm ² ].

  As the water of the hydrogel layer, natural water such as hot spring water and spring water, tap water, purified water, various water such as ion exchange water can be used. In the present invention, since a part of the water contained between the hydrated gel layer and the moisturizing layer (B) to be described later moves during and during use, the amount of water to be blended in the hydrated gel layer is as follows: 50 to 95% by mass is preferable, more preferably 55 to 90% by mass, based on the total mass. Within this range, the solubility and dispersibility of water, the gelling agent, and other components are good, which is preferable in terms of workability and moisturizing effect. If the water content is too small, the dispersion and solubility of the anionic polymer and other compounding bases will be insufficient, resulting in a decrease in workability during production and a decrease in the shape retention of the formed hydrous gel layer. Problems such as non-uniformity occur. Moreover, when there is too much the content, the shape retention property of a water-containing gel will fall, and malfunctions, such as a gel tearing at the time of use, will arise.

  As an anionic polymer, the polymer which has a carboxyl group, a sulfate group, and a phosphoric acid group is mentioned, for example. Specific examples include anionic cellulose derivatives such as carboxyvinyl polymer, carboxymethylcellulose, and carboxyethylcellulose, carrageenan, alginic acid and salts thereof, and anionic starch derivatives. In particular, poly (meth) acrylic acids, anionic cellulose derivatives, in order to obtain a water-containing gel layer that satisfies all of the high water retention, sufficient gel strength, and flexibility that can follow the unevenness and movement of the skin, It is preferable that at least one or more of carrageenan is included. In addition, an anionic cellulose derivative, especially carboxymethyl cellulose, is easy to control the moisture balance of the hydrated gel layer and the moisturizing layer at the time of lamination, can maintain the moisture content of the moisturizing layer high, and is easily available industrially at a low price. preferable.

  The content of the polymer is preferably 0.5 to 25% by mass, more preferably 3 to 10% by mass in the hydrogel stock solution at the time of blending. In addition, in order to improve the shape retention of the crosslinked gel by adjusting the viscosity of the uncrosslinked gel or physically entangled with the network structure of the anionic polymer, The content of the functional polymer is preferably 0.5 to 6% by mass in the hydrogel stock solution.

As the crosslinking agent, a metal ion compound, a cationic polymer, or a polyfunctional epoxy compound can be used, and is appropriately selected depending on the reactivity with the functional group of the anionic polymer to be used.
Examples of the metal ion compound include oxides, hydroxides, and salts containing aluminum, magnesium, calcium, potassium, and the like. For example, aluminum hydroxide, potassium alum, aluminum sulfate, aluminum oxide, aluminum glycinate, aluminum acetate , Aluminum lactate, aluminum stearate, hydrous aluminum silicate, aluminum metasilicate, magnesium aluminate metasilicate, magnesium chloride, magnesium stearate, calcium carbonate, calcium hydroxide, kaolin, synthetic hydrotalcite, potassium hydroxide, etc. These 1 type or 2 types or more can be mix | blended and used.

  As the cationic polymer, polyamino acids such as polylysine can be used.

  Polyfunctional epoxy compounds include ethylene glycol diglycidyl ether, polyethylene glycol diglycidyl ether, glycerin diglycidyl ether, glycerin triglycidyl ether, propylene glycol diglycidyl ether, polyglycerol polyglycidyl ether, sorbitol polyglycidyl ether, sorbitan Examples thereof include polyglycidyl ether, trimethylolpropane polyglycidyl ether, pentaerythritol polyglycidyl ether, resorcinol diglycidyl ether, neopentyl glycol diglycidyl ether, and the like, and one or more of these can be used in combination. In particular, when an anionic cellulose derivative such as carboxymethylcellulose is selected as the anionic polymer, an aluminum ion compound such as magnesium aluminate metasilicate and aluminum hydroxide is preferred as the crosslinking agent.

  The content of the crosslinking agent in the hydrogel layer is preferably 0.01 to 10% by mass, more preferably 0.05 to 5% by mass, and particularly preferably 0.1 to 2% by mass in the hydrogel stock solution. .

  In the hydrogel layer of the present invention, in addition to water, an anionic polymer, and a crosslinking agent, if necessary, a water-soluble polymer, a humectant, an oil agent, as long as the crosslinked state and storage stability are not adversely affected. Surfactants, pH adjusters, medicinal ingredients, preservatives, antioxidants, ultraviolet absorbers, solubilizers, colorants, fragrances and the like can be appropriately blended.

The water-soluble polymer is appropriately blended for the purpose of, for example, adjusting the viscosity of an uncrosslinked gel or improving the shape retention of the crosslinked gel by being physically entangled with the network structure of the anionic polymer.
Examples of the water-soluble polymer used include natural polymers such as gelatin, agar, pectin, xanthan gum, locust bean gum, gellan gum, tragacanth gum, gum arabic, glucomannan, guar gum, HP guar gum, and tuberose polysaccharides; Polyvinyl compounds such as PVA, PVP, polyvinylpyrrolidone / vinyl acetate copolymer; nonionic cellulose derivatives such as methylcellulose, ethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose; soluble starch, pullulan, dextrin, Examples thereof include starch degradation products or starch derivatives such as hydroxyalkyl starch and starch acetate, and one or more of these. It can be used in combination. The content of the water-soluble polymer compound is preferably 0 to 5% by mass in the hydrogel.

  Examples of the humectant include glycerin, diglycerin, polyglycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol, polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, methyl Examples include glucoside, polyoxyethylene methyl glucoside, erythritol, xylitol, sorbitol, mannitol, maltitol, trehalose and other polyhydric alcohols, sugar alcohols, saccharides, amino acids and derivatives thereof, proteins and derivatives thereof, etc. These can be used alone or in combination. Since these humectants have high water retention properties, it is possible to suppress extreme drying of the water-containing gel layer and maintain flexibility for the body patch sheet to follow the unevenness of the skin. At the same time, these humectants can be continuously supplied to the skin via (B) the humectant layer by blending in the hydrated gel layer. In particular, a humectant such as glycerin or propylene glycol that is liquid at room temperature and pressure is preferable because it has a function as a dispersant for an anionic polymer when the hydrogel is blended. The content of the humectant is preferably 1 to 50% by mass, particularly 1 to 40% by mass in the hydrogel stock solution.

Oils include jojoba oil, olive oil, avocado oil, mint oil, camellia oil, grape seed oil and other vegetable oils; animal oils such as mink oil and lanolin; hydrocarbons such as liquid paraffin, squalane and squalene; stearyl alcohol, isostearyl Higher alcohols such as alcohol and cetyl alcohol; ester oils such as isopropyl myristate, oleyl oleate and neopentyl glycol dicaprate; ether oils such as ethylene glycol dioctyl ether; dimethyl silicone oil, alcohol-modified silicone oil, alkyl-modified Silicone oils such as silicone oils and amino-modified silicone oils; fluorine oils such as perfluoropolyethers, and the like can be used, and one or more of these can be used in combination.
The amount of oil added depends on the cross-linked state and storage stability of the water-containing gel layer, and depending on the purpose of use, for example, supplying insufficient oil to the skin to prevent excessive moisture evaporation from the skin and moisturize. When used for enhancing the effect or exerting the function of the oil agent such as enhancing the skin permeability of the medicinal component, the content of the oil agent is preferably in the range of 0.01 to 20% by mass in the hydrogel stock solution. . In addition, these oils can also be more easily distributed to the skin by being blended in the moisturizing layer on the affixed surface as an emulsion or solubilized product, similarly to the moisturizing agent.

The surfactant is used for emulsifying or solubilizing the oil agent and uniformly dispersing it in the hydrous gel. Surfactants are generally used for cosmetics, for example, anionic surfactants such as sodium dialkylsulfosuccinate, sodium dodecylbenzenesulfonate, alkyl sulfate ester salts; hexadecyltrimethylammonium chloride, octadecyldimethyl Cationic surfactants such as benzylammonium chloride; polyoxyethylene stearyl ether, polyoxyethylene octyldodecyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene octylphenyl ether, polyoxyethylene monostearate, sorbitan monostearate, Sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monolaurate, polyoxyethylene Nonionic surfactants such as sorbitan monooleate, tetraoleic acid polyoxyethylene sorbitol, glycerin fatty acid ester, polyglycerin fatty acid ester, polyethylene glycol monostearate, polyoxyethylene hydrogenated castor oil, polyoxyethylene octadecylamine; Examples include amphoteric surfactants such as betaine and lauryl dimethylamine oxide, and these can be used alone or in combination.
Although content of surfactant is suitably set by the kind and compounding quantity of the oil agent to be used, it is preferable that it is the range of 0.01-10 mass% in a hydrous gel stock solution.

  Examples of pH adjusters include tartaric acid, succinic acid, citric acid, lactic acid, malic acid, acetic acid, glycolic acid, hydrochloric acid, oxalic acid, phosphoric acid, sodium hydroxide, potassium hydroxide, methylamine, dimethylamine, trimethylamine, ethylamine, Diethylamine, triethylamine, propylamine, dipropylamine, tripropylamine, monomethanolamine, dimethanolamine, trimethanolamine, monoethanolamine, diethanolamine, triethanolamine, monopropanolamine, dipropanolamine, tripropanolamine, citrate Acid salts, phosphates, carbonates and the like can be mentioned. The pH of the hydrated gel layer is preferably adjusted to a range of 4 to 8, and the content of the pH adjuster is preferably in the range of 0.01 to 10% by mass in the hydrated gel stock solution.

Examples of medicinal ingredients include various skin beautifying ingredients and other medicinal ingredients.
The skin-beautifying component is a component in which actions such as a whitening effect, a fine wrinkle / sag improvement effect, a turnover improvement effect, a slimming effect, a moisturizing effect, an astringent effect, and an emollient effect are recognized. Like these moisturizers, these ingredients can be further distributed to the skin by blending them into the moisturizing layer on the application surface. Can be continuously supplied to the skin.

  As the skin beautifying component, any of various active substances for skin beautifying used in cosmetics can be used, such as ceramides, vitamins (vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, and derivatives thereof. Hyaluronic acid and its salt, chondroitin sulfate and its salt, tuberose polysaccharide, amino acid and its derivatives and protein degradation products, organic acids such as hydroxy acid, glycoprotein such as lactoferrin, ubidecalenone (coenzyme Q10), α lipoic acid (Thioctic acid), animal and plant extracts, urea and the like can be mentioned, and these can be used alone or in combination. The content of the beautifying skin component is preferably in the range of 0.01 to 20% by mass in the hydrated gel stock solution.

  Other medicinal components are components that are recognized to have effects such as blood circulation promoting action, anti-inflammatory analgesic action, and antipruritic action. Examples of medicinal ingredients include nicotinic acid and its derivatives, vitamin E and its derivatives, salicylic acid and its salts, glycyrrhizic acid and its salts, allantoin, guaiazulene, diphenhydramine hydrochloride, lysozyme chloride, caffeine, carnitine, and the like. These 1 type (s) or 2 or more types can be used in combination. The content of these medicinal ingredients is preferably in the range of 0.01 to 20% by mass in the hydrated gel stock solution.

  Examples of preservatives include paraoxybenzoic acid ester, benzoic acid and its salt, sorbic acid and its salt, dehydroacetate, phenol, isopropylmethylphenol, hinokitiol, benzalkonium chloride, benzethonium chloride, chlorhexidine chloride, etc. These can be used alone or in combination. The content of the preservative is preferably in the range of 0.01 to 5% by mass in the hydrogel stock solution.

  Examples of the antioxidant include ascorbic acid and a salt thereof, ascorbic acid ester, carotene, astaxanthin, propyl gallate, butylhydroxyanisole, dibutylhydroxytoluene, and the like, and these can be used alone or in combination.

  Examples of the ultraviolet absorber include paraaminobenzoic acid and esters thereof, amyl paradimethylaminobenzoate, oxybenzone, tetrahydroxybenzophenone, hydroxymethoxybenzophenonesulfonic acid, and sinoxate.

  The solubilizer is used to uniformly disperse a slightly water-soluble medicinal component in a water-containing gel, and specific examples thereof include lower alcohols such as ethyl alcohol, propyl alcohol, butyl alcohol, and benzyl alcohol.

  About a coloring agent, it leads to the improvement of a feeling of use and the activation of skin. Colors include Red No. 102 (New Cotion), Red No. 104- (1) (Phloxine B), Red No. 105- (1) (Rose Bengal), Red No. 106 (Assid Red), Red No. 2 ( Amaranth), Red 3 (Erythrosin), Yellow 4 (Tartrazine), Yellow 5 (Sunset Yellow FCF), Green 3 (Fast Green FCF), Blue 1 (Brilliant Blue FCF), Blue 2 (Indigo) And legal dyes such as carmine).

  The fragrance is not particularly limited, and can be appropriately blended from fragrances that can be used in the fields of pharmaceuticals, quasi drugs, cosmetics, sanitary materials, sundries, and the like.

  The moisturizing layer (B) of the present invention is a viscous liquid (gel form) in which hyaluronic acids are dissolved or dispersed in water and do not gel in order to develop sufficient tackiness, A layer that is transferred to the skin. Transfer to the skin means that the sheet of the present invention is applied to the skin, and when the gel layer is peeled off from the skin after a certain time, it is transferred from the gel layer side to the skin side, that is, the moisturizing layer remains on the skin sufficiently. Means. The viscosity of the moisturizing layer is from 100 to 1,000,000 mPa · when a 20% aqueous solution of the moisturizing layer (B) is prepared (25 ° C.) from the viewpoint of adhesiveness to the skin during use and transferability to the skin. s, more preferably 300 to 800,000 mPa · s, and particularly preferably 500 to 600,000 mPa · s. The viscosity is measured with a B-type viscometer.

  Examples of hyaluronic acid, hyaluronic acid decomposition products, hyaluronic acid derivatives and salts thereof used in the moisturizing layer (B) of the present invention include hyaluronic acid, sodium hyaluronate, hyaluronic acid and sodium hyaluronate, Examples include acetylated hyaluronic acid. The average molecular weight of these hyaluronic acids to be used is 5 million to 7 million for chicken tosaka, and 1 million to 3 million for those purified by microbial fermentation such as lactic acid bacteria, depending on the source of hyaluronic acid. It is preferable to use a degradation product of hyaluronic acid, acetylated hyaluronic acid, or the like, and it is preferable to use these in combination with hyaluronic acid or sodium hyaluronate. The average molecular weight of the decomposition product of hyaluronic acid is 1,000 to 1,500,000, more preferably 5,000 to 1,000,000, still more preferably 60,000 to 1,000,000.

  These hyaluronic acids are contained in the moisturizing layer of the sheet for body sticking of the present invention in an amount of 1.5 to 5% by mass, and the moisture content is stably maintained on the hydrated gel layer, and further to the skin at the time of application. From 1 to 2% by mass in the moisturizing layer (B) is preferable in terms of adhesion and transfer of the moisturizing layer to the skin without stickiness to the skin at the time of peeling, and retaining moisture, and further eliminating powder blowing during drying, In particular, the content is preferably 1.8 to 3% by mass.

  Also, the moisturizing layer (B) is transferred to the skin after being applied and peeled off to swell the stratum corneum, to impart and retain moisture, to increase the skin permeability of the active ingredient, and to prevent stickiness From the standpoints of maintaining a good feeling of use and maintaining the skin adhesion at the time of application, the water at the time of adjusting the moisturizer solution is 50 to 95% by mass, more preferably 55 to 90% by mass, especially 60 to 70%. It is preferable to be contained by mass%.

The moisturizing layer (B) of the present invention further includes other water-soluble polymers excluding hyaluronic acids, plasticizers, moisturizers, oils, surfactants, pH adjusters, medicinal ingredients, preservatives, antioxidants, Ultraviolet absorbers, solubilizers, colorants, fragrances and the like can be appropriately blended. The component used here can illustrate the same thing as the said water-containing gel layer (A). The total amount of these components is preferably appropriately blended in the range of 3.5 to 50% by mass in the moisturizing layer (B).
In particular, as a water-soluble polymer other than hyaluronic acid, it may be the same as or different from the component optionally contained in the above-mentioned water-containing gel layer. The water-soluble polymer having an average molecular weight of 5,000 to 5,000,000 is preferably 5% by mass or less, particularly 0.01 to 3% by mass in the moisturizing layer.

  The sheet for body patch of the present invention has a structure in which the water-containing gel layer (A) and the moisturizing layer (B) are laminated, and an aqueous solution containing 1.5 to 5% by mass of the hyaluronic acid. It can be produced by directly laminating the (A) hydrogel layer.

As a method of laminating, for example, a hyaluronic acid-containing aqueous solution is dropped into a flat container such as a tray, and (A) a hydrogel layer is placed thereon. Thereafter, the mixture is allowed to stand for 24 to 72 hours, and a part of the hyaluronic acid-containing aqueous solution penetrates into the water-containing gel layer to form a gel-like moisture retention layer. The concentration of hyaluronic acid in the aqueous solution to be dropped is 1 to 5% by mass, but it is obtained in consideration of the transfer of moisture and low molecular weight substances between the water-containing gel layer and the moisturizing layer in the final form sheet. It is preferable that it is the same concentration as the gel layer of the obtained sheet agent.
At this time, the water in the hydrogel layer and the water in the hyaluronic acid-containing aqueous solution are water gel layers caused by dissociation of ionic groups of the anionic polymer in the hydrogel layer or hydration power of humectants such as polyols. It is preferable to adjust the amount of hyaluronic acid and the amount of water in the hyaluronic acid aqueous solution so that the water content is balanced with the water holding power of the hyaluronic acid-containing aqueous solution.
The amount of the moisturizing layer containing hyaluronic acid formed on the gel layer surface in the equilibrium moisture state is 0.003 to 0.025 g / cm ² per unit area of the gel layer when the specific gravity of the moisturizing layer is 1. A range is preferable, and a range of 0.005 to 0.02 g / cm ² is more preferable. The adhesion amount here means (i) the weight of the two-layer gel sheet taken out from the tray, (ii) the weight of the gel sheet after wiping off the moisture retaining layer of the two-layer gel sheet taken out from the tray, and (iii) the moisture retaining layer is formed. It is a value calculated by the following formula when it is defined as the gel sheet area of the portion that has been done.
Adhesion amount = [(i) − (ii)] ÷ (iii)

  If it does in this way, the sheet agent by which the water-containing gel layer (A) and the moisture retention layer (B) were laminated | stacked in the tray will be formed.

  In the sheet agent of the present invention, the final form sheet agent may be put in a packaging container (pillow) or the tray may be put in a packaging container (pillow).

  Moreover, when adding gas, such as a carbon dioxide, to the sheet | seat for body sticking of this invention, a sheet agent is put in a packaging container (pillow), and the air in a packaging container (pillow) is then replaced | exchanged for a carbon dioxide. It can be manufactured by a method. Further, the tray on which the sheet is formed may be put in a packaging container (pillow) as it is, and then the air in the packaging container (pillow) is replaced with carbon dioxide. The filling amount of carbon dioxide in the packaging container (pillow) is 0.5 to 5 times, preferably 1.0 to 3 times the volume of the gel in the sheet, thereby providing sufficient blood circulation. Carbon dioxide sufficient to obtain an accelerating effect can be sufficiently dissolved in the gel-like moisturizing layer and gel layer. In addition, when laminating a plastic film, which will be described later, on one side of the water-containing gel layer (A), in order to dissolve carbon dioxide in the gel-like moisturizing layer and the water-containing gel layer, a plastic such as polyethylene or polypropylene having a gas permeability as high as possible. It is preferred to use the film on at least one side.

The obtained sheet | seat agent of this invention has a water-containing gel layer and a moisture retention layer, and a moisture retention layer is a sticking surface. Since the moisturizing layer formed on the affixing surface can contain medicinal ingredients other than hyaluronic acid, its concentration can be higher than that of the hydrogel layer, and the hydrous gel like conventional single-layer gel sheets. Rather than blending medicinal ingredients into the entire layer, the distribution efficiency to the skin can be improved and the penetration can be made more efficiently. Furthermore, there is a cost merit that the same effect can be expressed in a small amount, rather than blending medicinal components with the entire hydrogel layer.
It is also possible to mix different medicinal ingredients in the hydrated gel layer and the moisturizing layer, and in particular, agents that may adversely affect the crosslinked state and storage stability of the hydrated gel layer (for example, oil agents and emulsifiers) ) Is incorporated only during the formulation of the moisturizing layer, it is possible to maintain both the basic physical properties and storage stability of the gel layer and to blend the medicinal components.

  Also, a plastic film can be laminated on the surface of the hydrogel layer (A) on the side opposite to the sticking surface to prevent moisture evaporation.

  The obtained sheet agent of the present invention can be used by peeling off a plastic film if necessary and sticking it on the body (face, etc.) using the moisturizing layer as a sticking surface. Since the moisturizing layer is a viscous liquid, a part thereof is transferred onto the skin after peeling. Therefore, the sheet agent of the present invention has good adhesiveness to the skin. Moreover, after sticking, you may hold | maintain for a fixed time, and the medicinal component in a moisturizing layer can also be osmose | permeated to skin by rubbing the moisturizing layer transcribe | transferred on the skin after peeling a water-containing gel layer.

Examples 1-3
<Preparation method of hydrous gel>
An uncrosslinked hydrated gel stock solution having the formulation shown in Table 1 was prepared. In the preparation method, a mixed liquid of glycerin and propylene glycol was put into a kneader, carboxymethylcellulose, aluminum hydroxide, and methyl paraoxybenzoate were added in this order to prepare a slurry, and an aqueous succinic acid solution was further mixed.

This uncrosslinked hydrated gel stock solution was sandwiched between plastic (PET) films and spread with a baker type applicator so that the hydrated gel had a thickness of 2 mm. Furthermore, it was aged at 50 ° C. for 5 days to complete the crosslinking reaction of the hydrogel layer, and a crosslinked hydrogel sheet was obtained. Thereafter, the die was cut into the shape shown in FIG. 2 (area 32 cm ² ).

<Preparation of moisturizing liquid and production of laminated sheet>
A moisturizing liquid was prepared according to the formulation shown in Table 2. At this time, L-5 having a large amount of hyaluronic acid was not suitable for the production of a sheet because the sodium hyaluronate was not sufficiently dissolved, the solution was not uniform, and the viscosity was not very fluid. there were.
The moisturizing liquids L-1 to L-3 in Table 2 were dropped into the storage parts (recesses) of the plastic plastic trays shown in FIG. The plastic film on one side of the gel sheet was peeled off and placed so that the moisturizing liquid in the tray was in contact with the peeled surface, and then the tray with the gel sheet was inserted into an aluminum pillow and heat sealed.
The moisturizing liquid in the tray was aged at room temperature for 3 days. As a result, a moisturizing liquid spread uniformly on the surface of the water-containing gel sheet, and a two-layered water-containing gel sheet having a moisturizing layer was obtained. Table 3 shows combinations of the obtained hydrogel layer and the moisturizing liquid (Examples 1 to 3).

The tray was designed so that two 32 cm ² eye sheets could be placed (see FIGS. 1 and 2).

  From 6 sheets of this tray, the moisturizing layer after aging for 3 days was collected, and the nitrogen concentration in the collected moisturizing layer was measured with a trace total nitrogen analyzer (TN-100, manufactured by Mitsubishi Chemical Corporation). The sodium hyaluronate content in the moisturizing layer was calculated from this nitrogen concentration. At this time, it was calculated that 90% by weight of polyvinylpyrrolidone remained in the moisture retaining layer. As a result, in the sheet agents of Examples 1 to 3, the sodium hyaluronate content in the moisturized layer after aging was 2.4 to 2.6% by weight as shown in Table 4. On the other hand, in the sheet material of the comparative example, it was 0.9% by weight.

<Evaluation test>
Using the gel sheets prepared in Examples and Comparative Examples, the moisture retention layer was applied to the eyes for 15 minutes using the gel layer, and sensory evaluation was performed on the following five items.

A: “Adhesion” of the sheet during application
(Double-circle): The sheet | seat adheres to the eyes stably, without shifting with respect to movements, such as blink.
○: Slightly shifted with respect to movement such as blinking, but the sheet is almost adhered to the pasting position.
(Triangle | delta): Although it shifts | deviates gradually from an eye part in a stationary state, it does not peel off.
X: Even in a stationary state, it is greatly displaced downward from the eye and peels off.
B: “Moisturizing feeling” of the moisturizing layer transferred to the skin when the sheet is peeled off
A: The moisturizing layer is sufficiently transferred to the skin, and there is a moist feeling even after being applied on the skin.
○: A moisturizing layer is significantly transferred to the skin, and there is a moist feeling even after applying on the skin.
(Triangle | delta): A moisturizing layer is slightly transcribe | transferred to skin and there is no moist feeling after making it fit on skin.
X: The moisturizing layer is not transferred to the skin and there is no moist feeling.
C: “Sticky” after the transferred moisturizing layer is applied to the skin
A: After applying, it is not sticky.
○: After sticking in, it is not sticky.
Δ: Slightly sticky after applying.
×: Sticky after familiarizing.
D: “Powder / powder” after drying by soaking in the moisturizing layer
A: White and no powder residue or powder blowing.
○: There is almost no white powder residue or powder blowing.
△: Slightly white powder residue or powder blow ×: White powder residue or powder blow

  As a result, as shown in Table 5, the sheet preparations of Examples 1 to 3 were good results in all items A to D. On the other hand, in the sheet of the comparative example, the adhesiveness, the skin transferability of the moisturizing layer, and the moist feeling were good, but the transferred moisturizing layer was sticky, and there was powder residue and powder blowing on the dried skin Therefore, the result was insufficient.

The example of the shape of a tray is shown. The state which has arrange | positioned the sheet | seat on a tray is shown.

Claims (3)

  (A) A sheet agent for body patch having a structure in which a water-containing gel layer containing a crosslinked structure of an anionic polymer and (B) a moisturizing layer, a part of which is transferred onto the skin at the time of application, are laminated. The (B) moisturizing layer is a gel-like layer containing 1.5 to 5% by mass of one or more hyaluronic acids selected from hyaluronic acid, a hyaluronic acid decomposition product, a hyaluronic acid derivative and a salt thereof. The sheet agent for body sticking obtained by laminating | stacking the aqueous solution which contains this hyaluronic acid 1-5 mass%, and this (A) hydrous gel layer.   The sheet for body patching according to claim 1, wherein the anionic polymer is an anionic cellulose derivative.   The body patch sheet according to claim 2, wherein the anionic cellulose derivative is carboxymethylcellulose.