JP2019019114A - Hydrous composition, patch constituting hydrous composition, cosmetic or external skin pharmaceutical agent, and method for producing the same - Google Patents

Abstract

To provide hydrous compositions containing no paraben or a composition containing a remarkably minute amount of parabens, which can exert sufficient antiseptic properties and can expect to reduce skin sensitization, in a hydrous composition containing a functional component dissolved in water, and to provide cosmetics, skin external agents, and the like, with the hydrous composition.SOLUTION: Provided are a hydrous composition containing water and a functional component which is soluble in the water, the composition containing: a polyhydric alcohol which is soluble in or compatible with water and exerts antiseptic promotion action; and an antiseptic agent except parabens which is soluble in water and/or polyhydric alcohol, the antiseptic agent except paraben containing at least one antiseptic agent selected from the group consisting of phenoxyethanol, caprylic acid glyceryl, and polylysine, the hydrous composition having antiseptic properties; and a patch, a cosmetic or an external skin pharmaceutical agent, with the hydrous composition.SELECTED DRAWING: None

Description

Detailed Description of the Invention

  The present invention relates to a water-containing composition, and in particular, a water-containing composition containing water and a functional component, and a water-containing composition having antiseptic properties that can be expected to have reduced skin sensitization, and a water-containing composition thereof The present invention relates to a configured patch, cosmetic, or skin drug, and a method for producing the same.

Various proposals have been made for compositions containing preservatives in order to impart antiseptic properties to compositions such as cosmetics, pharmaceuticals, and foodstuffs.
The antiseptic properties are the types of functional ingredients contained in the water-containing composition (eg, protein-containing ingredients, natural materials such as agar, functional ingredients, water-soluble polymer ingredients, etc.), forms (eg, transparent liquid, emulsified) , Gel, gel), preservatives are dissolved in the composition or are contained in a dispersed state without being dissolved, composition, content, aqueous / oily, patch, cosmetics Depending on the type of product, such as the drug for the skin, etc., it varies significantly.
Further, it is said that the corrosiveness of the composition varies greatly depending on the difference in “water activity” between water and the functional component-containing composition. The water content of the composition containing water includes bound water chemically bonded to the components contained in the composition, dissolved water dissolving the contained components, and free water permeating into the surface and voids of the contained components. It is said that this water activity is closely related to the antiseptic properties of the composition.

  In general, a water-containing composition having a functional ingredient dissolved in water tends to be easily spoiled by bacteria over time such as during storage, and in order to prevent quality deterioration due to spoilage, paraoxy is used as a preservative. Water-containing compositions containing parabens such as methyl benzoate (methyl paraben) and provir paraoxybenzoate (propyl paraben) have been proposed.

  For example, as a cooling patch, Japanese Patent Application Laid-Open No. 2000-107219 (Patent Document 1) discloses a water retaining solution containing a water-soluble polymer such as polyacrylic acid, polyvinyl alcohol, carboxymethyl cellulose, and 40% by weight or more of water. For cold and moisturizing, in which at least a part of the fiber is exposed to the surface of the water-retaining base material, and the surface of the water-retaining base material is hydrophilic. A gel has been proposed, which can retain a large amount of water in the water-holding base material and has excellent moisture-holding ability. Also, moisture can easily move through the base material by the fibers, and these fibers make it possible to move from the water-holding base material to the outside. The volatilization of water easily occurs, and the effect of being excellent in cold insulation is disclosed. In particular, Example 1 in paragraph 0048 discloses a water-retaining matrix containing 0.1 g (0.1 wt%) of parabens.

  JP 2010-13470 (Patent Document 2) proposes a thin aqueous patch containing water, polyacrylic acid or sodium polyacrylate, carboxymethyl cellulose, and a sparingly soluble metal salt on a support. A patch that maintains the moisture protection effect on the skin and exhibits an excellent usability is disclosed. In particular, Example 4 in Table 2 discloses an adhesive containing both 0.1% by weight of propylparaben and 0.05% by weight of methylparaben.

  International Publication WO 2005/105150 (Patent Document 3) includes a support and a pressure-sensitive adhesive layer disposed on one surface of the support, the pressure-sensitive adhesive layer including water and readily soluble agar, and further includes polyacrylic acid. Alternatively, a patch comprising an adhesive base containing polyvinyl alcohol and polyvinyl pyrrolidone, wherein the adhesive base further contains an analgesic / anti-inflammatory component such as diclofenac, indomethacin, and loxoprofen has been proposed. In particular, paragraph 0076, Table 1, and Table 3 disclose a pressure-sensitive adhesive layer containing 0.2% by mass of methylparaben as a preservative.

  Japanese Patent Application Laid-Open No. 2007-145749 (Patent Document 4) Cosmetics containing an antiseptic disinfectant containing 1,2-alkanediol and lysozyme as an antiseptic disinfectant other than parabens instead of the parabens antiseptic Pharmaceuticals or food products are disclosed.

JP 2000-107219 A JP 2010-13470 A International Publication WO2005 / 105150 JP 2007-145749 A

  In the conventional water-containing composition, a composition containing parabens such as methyl paraoxybenzoate (methyl paraben) and provir paraoxybenzoate (propyl paraben) is generally proposed as an antiseptic. In water-containing compositions used for cosmetics or patches, parabens such as methyl paraoxybenzoate and provir paraoxybenzoate contained as preservatives have particularly low (or weak) skin resistance, such as infants and the elderly. ) It has recently been reported that when used by humans, there is skin sensitization of the contacted skin, such as the occurrence of skin irritation.

  In a water-containing composition containing a functional component dissolved in water, in a composition that does not contain parabens, or a composition that contains a very small amount of parabens and can exhibit sufficient antiseptic properties In addition, a water-containing composition that can be expected to reduce skin sensitization, and a cosmetic, an external preparation for skin, and the like provided with the water-containing composition are desired.

  The water-containing composition of the present invention is a water-containing composition containing (A) water and (B) a functional component soluble in the water, and at least (C) is soluble or phase-soluble in the water. A polyhydric alcohol having a soluble preservative promoting action, and (E) a preservative other than parabens soluble in water and / or polyhydric alcohol, and a preservative other than the parabens, It contains antiseptic other than at least one paraben selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine, and has antiseptic properties.

  As the polyhydric alcohol exhibiting antiseptic properties, at least one polyhydric alcohol selected from the group consisting of propylene glycol, butylene glycol and glycerin can be preferably implemented.

  A constitution in which the preservatives other than parabens contain both phenoxyethanol and glyceryl caprylate and / or polylysine can be preferably implemented.

  In the water-containing composition of the present invention, a constitution not containing a paraben preservative or a constitution containing a slight amount of parabens not exhibiting skin sensitization can be preferably implemented.

  A patch comprising the water-containing composition of the present invention comprises a water-containing composition and a sheet-like holding member, and the water-containing composition is attached and / or impregnated and held on the sheet-like holding member, The functional component contained in the water-containing composition contains a water-soluble polymer that is soluble in water, is formed so as to be pastable on human skin, and has antiseptic properties.

  In the method for producing an antiseptic water-containing composition of the present invention, the water-containing composition comprises (A) water, (B) a functional component soluble in the water, and (C) soluble in the water. A polyhydric alcohol having a compatible preservative promoting effect and (E) a preservative other than the parabens soluble in the water and / or the polyhydric alcohol, and a preservative other than the parabens, A preservative-containing water-containing composition comprising a preservative other than at least one paraben selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine. ) At least a functional component that is soluble in water is mixed and dissolved in water, thereby preparing a functional component-containing preconditioning solution, (c) a preservative other than parabens, and the preservative. Dissolvable water and / or multivalent A step of preparing a preservative-containing preconditioning solution containing a preservative dissolved therein, (e) a polyhydric alcohol, and the functional component prepared in (a) above. Mixing the preconditioning liquid and the preservative-containing preconditioning liquid prepared in (c), thereby preparing a water-containing composition in which the functional ingredient and the preservative are dissolved, It is characterized by having.

  A method for producing a patch comprising the water-containing composition of the present invention comprises a sheet-like holding member and a water-containing composition that is attached and / or impregnated and held on the sheet-like holding member, and is applied to human skin. A method for producing a patch, wherein the water-containing composition comprises (A) water and (B) a water-soluble polymer as a functional component that is soluble in the water, and at least , (C) a polyhydric alcohol having an antiseptic promoting action that is soluble or compatible with the water, and (E) a preservative other than parabens soluble in the water and / or the polyhydric alcohol. And the preservative other than the parabens contains at least one preservative other than the parabens selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine, and has a temperature of about 45 ° C. or less. In It has a gel shape that is soft and sticky and has no fluidity, is antiseptic, and can be applied to human skin, and (a) is highly soluble in water at least. A step of preparing a water-soluble polymer-containing preparation solution having viscosity and fluidity by mixing and dissolving molecules in water, (c) a preservative other than parabens, and the preservative A step of mixing a dissolvable water and / or a polyhydric alcohol, thereby preparing a preservative-containing preconditioning solution containing the preservative dissolved therein, (e) the polyhydric alcohol, and the (a) The water-soluble polymer-containing preconditioning liquid prepared by the above and the preservative-containing preconditioning liquid prepared by (c) are mixed, whereby the preservative is dissolved and viscous. Fluidity and fluidity, fluidity and moisture content A step of preparing a child composition, wherein the fluid hydrous polymer composition is adjusted to a predetermined temperature; (f) after the step (e), the fluid hydrous polymer composition is gelled; When the fluidity is maintained until the sheet-like holding member is adhered and / or impregnated with a predetermined thickness to the sheet-like holding member, this holds the sheet-like holding member. A step of preparing a flowable water-containing polymer composition with a sheet-like holding member, (g) adjusting the fluid water-containing polymer composition with a sheet-like holding member prepared in the step (f) to a predetermined temperature, Thus, the method comprises a step of preparing a patch comprising the water-containing composition in which the fluid water-containing polymer composition is gelled in a gel state having no fluidity.

  According to the water-containing composition of the present invention (effect i: a water-containing composition that exhibits reduced skin sensitization and excellent antiseptic properties) contains functional components such as water and a water-soluble polymer, and also contains parabens. In a water-containing composition not containing water or a water-containing composition containing a very small amount of parabens, a water-containing composition that can exhibit sufficient antiseptic properties and has reduced skin sensitization is obtained. In particular, when a person with low skin resistance (or a weak person) such as an infant or an elderly person uses it, a water-containing composition that is expected to have reduced skin sensitization and exhibits excellent antiseptic properties can be obtained.

  By using the patch comprising the water-containing composition of the present invention, (Effective Patch-Patch having reduced skin sensitization / excellent antiseptic properties) a person with low skin resistance (or a weak person) is applied to the skin. When applied, it is expected to reduce skin sensitization such as skin irritation on the skin and to obtain a patch exhibiting excellent antiseptic properties. A patch having basic patch performances such as formability, flexibility, easy-peeling adhesiveness, and peel-remaining suppression is obtained. In particular, when a person with low skin resistance, such as an infant or an elderly person, is used, a reduced skin sensitization is expected, and a patch exhibiting excellent antiseptic properties can be obtained.

  According to the method for producing a water-containing composition of the present invention, a preservative other than paraben can be dissolved in water and / or a polyhydric alcohol in which a functional component is dissolved, and sufficient antiseptic properties can be exhibited. A water-containing composition with reduced sensitization is obtained.

  According to the method for producing a patch comprising the water-containing composition of the present invention, (Effect: Method for producing a patch having basic performance required for a patch and having reduced skin sensitization and excellent antiseptic properties) ) Preservatives other than parabens can be included in a state dissolved in the water-containing composition, so that a person with low skin resistance (or a person with low skin resistance) uses it when attached to the skin. It is expected to reduce skin sensitization, such as skin irritation, and has excellent antiseptic properties. In particular, the adhesiveness, shape retention, flexibility, easy-to-peel adhesiveness, and residual peelability required for patches A patch having basic patch performance such as inhibitory properties can be produced.

It is a schematic process explanatory drawing explaining the manufacturing process of the manufacturing method of the patch provided with the water-containing composition of one Example of this invention. It is a figure explaining an example which determines the preservative effect produced by the case where 2 types of preservatives are mix | blended.

  The water-containing composition of the present invention is a water-containing composition containing (A) water and (B) a functional component soluble in the water, and at least (C) is soluble or phase-soluble in the water. A polyhydric alcohol having a soluble preservative promoting action, and (E) a preservative other than parabens soluble in water and / or polyhydric alcohol, and a preservative other than the parabens, It contains antiseptic other than at least one paraben selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine, and has antiseptic properties.

<About the effect of promoting the antiseptic properties of polyhydric alcohols in water-containing compositions containing other preservatives other than parabens>
In the water-containing composition of the present invention, as the polyhydric alcohol, at least one polyhydric alcohol of propylene glycol, butylene glycol and glycerin is contained, and as a preservative, at least phenoxyethanol, glyceryl caprylate, and Containing at least one preservative selected from the group consisting of polylysine, and by having a polyhydric alcohol and a preservative, the polyhydric alcohol has a preservative promoting effect that promotes the preservative of the preservative. It is.
With this configuration, the above-mentioned (Effect A) and (Effect W: Preservative promoting effect by inclusion of polyhydric alcohol and other preservative) Propylene glycol, butylene glycol and / or glycerin as polyhydric alcohol By containing, the antiseptic property promoting effect of promoting the antiseptic action of preservatives other than these parabens is exhibited. In other words, the combined use of these polyhydric alcohols and preservatives other than parabens such as phenoxyethanol, glyceryl caprylate, and polylysine has the effect of reducing the minimum preservative concentration of preservatives other than parabens. can get.
Although this effect was found in this experiment, it is presumed that these polyhydric alcohols have some preservative promoting effect in the addition of phenoxyethanol, glyceryl caprylate, or polylysine preservative. The

In terms of antiseptic properties, propylene glycol contains 3% by weight or more with respect to the total content, or butylene glycol contains 3% by weight or more with respect to the total content, or glycerin has a total content of On the other hand, a composition containing 5% by weight or more can be desirably implemented and exhibits an antiseptic property promoting effect. When the content of propylene glycol alone or butylene glycol alone is less than 3% by weight as the polyhydric alcohol, or when the content of glycerin alone is less than 5% by weight, there is a tendency not to exhibit a sufficient antiseptic effect. is there.
In addition, it is a case where content of polyhydric alcohol exceeds 50 weight%, Comprising: When using as a patch especially, there exists a tendency to be inferior to shape retention property or a residue control after peeling.
A constitution containing both propylene glycol and butylene glycol and a total amount of these containing 3% by weight or more is also feasible and exhibits an antiseptic property. A configuration in which two or more of propylene glycol, butylene glycol, and glycerin are included and the total amount of these polyhydric alcohols is 3% by weight or more is also feasible and exhibits antiseptic properties.

The water-containing composition does not contain parabens but contains propylene glycol, butylene glycol and / or glycerin and also contains a preservative other than the above-mentioned parabens, and also exhibits excellent antiseptic properties.
Further, even when the water-containing composition contains the parabens in an amount of 0.05% by weight or less based on the total amount and contains the polyhydric alcohol and a preservative other than the parabens, It can be expected to reduce skin sensitization.

According to known literature, the polyhydric alcohol has the following properties.
Propylene glycol has a melting point of −59 ° C. and a boiling point of 188.2 ° C., has a slightly viscous liquid at room temperature, is easily miscible / compatible with water, and is easily miscible / compatible with ethanol. Dipropylene glycol has a melting point. It has a viscosity of −39 ° C. and a boiling point of 232.2 ° C., has a viscous liquid at room temperature, is easily miscible / compatible with water, and is easily miscible / compatible with ethanol. Butylene glycol is another name, 1,3-butylene glycol, 1,3-butanediol, or 1,3-dihydroxybutane, has a viscous liquid at room temperature, and is easily miscible and compatible with water. Yes, it is easily miscible and compatible with ethanol. Glycerin, also known as glycerol, has a melting point of about 18 ° C., but is easily supercooled, difficult to crystallize, has a highly viscous liquid at room temperature, and is easily miscible and compatible with water. Is easily miscible and compatible.

<Water-containing composition containing preservatives other than parabens>
In the water-containing composition of the present invention, the preservative other than the parabens is composed of phenoxyethanol soluble in polyhydric alcohol, glyceryl caprylate soluble in polyhydric alcohol, and polylysine soluble in water. A construction comprising at least one preservative other than parabens selected from the above can be implemented.

  With this configuration, (effect i-abd: reduced skin sensitization / excellent antiseptic properties) a configuration comprising at least one preservative selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine Therefore, when used by people with low skin resistance, it is expected to reduce skin sensitization, such as skin irritation, and it contains functional components dissolved in water that provide excellent antiseptic properties. A water-containing composition and a cosmetic or a patch comprising the water-containing composition are obtained.

  Further, without containing a parabens preservative, a preservative other than the parabens is phenoxyethanol that is soluble in the water and / or the polyhydric alcohol, and hardly soluble in the water, but is soluble in the polyhydric alcohol. A configuration containing at least one preservative selected from the group consisting of soluble glyceryl caprylate and the water-soluble polylysine preservative is also possible. Thereby, the water-containing composition which exhibits the effect of reducing the skin sensitization as described above (effect i-abd: reduced skin sensitization / excellent antiseptic property) can be obtained.

  Known properties of the antiseptic contained in the water-containing composition of the present invention are shown in Table 1. In the publicly known literature, the solubility of these preservatives in water, ethanol, propylene glycol and the like is disclosed, but solubility data for other polyhydric alcohols could not be found.

<About the water-containing composition containing phenoxyethanol>
In the water-containing composition of the present invention, a constitution in which the preservative other than parabens desirably contains 0.2 to 1.0% by weight of phenoxyethanol with respect to the total content is desirable. More preferably, phenoxyethanol is dissolved or mixed in the water-containing composition.
With this configuration, (effect a-a: containing phenoxyethanol / reduced skin sensitization / excellent antiseptic properties), in which phenoxyethanol is dissolved or mixed, it is used by people with low skin resistance. A water-containing composition containing a functional component dissolved in water, which is expected to reduce skin sensitization such as skin irritation on contact and has excellent antiseptic properties, is obtained.

  In addition, it is possible to implement a configuration in which the preservative other than the parabens contains a phenoxyethanol preservative without containing a paraben preservative. Thereby, the water-containing composition which exhibits the effect of reducing the skin sensitization as described above (Effect Ia: reduced skin sensitization / excellent antiseptic property) can be obtained.

Phenoxyethanol has a boiling point of about 245 ° C. and a freezing point of about 13 degrees, is a colorless and transparent liquid with a slight fragrance and a slightly viscous liquid, and is widely used as an excellent solvent for various organic substances. In the cosmetic field, it is also used as a preservative for preventing the oxidation of contained components. The solubility in water is about 2.8% by weight at 20 ° C.
On the other hand, according to the known literature, parabens are hardly soluble in water. In terms of solubility in water, methylparaben is about 0.25 wt%, ethylparaben is 0.17 wt%, and propylparaben is 0.04 wt%. %, Butylparaben is 0.02% by weight. That is, phenoxyethanol has the property of being more soluble in water than parabens.
Generally, according to known literature, phenoxyethanol is said to be safer for human health than parabens, however, it is desirable to have a content as low as possible. Further, when a preservative such as phenoxyethanol is contained as a preservative for cosmetics, the antiseptic effect varies significantly depending on the type of other components contained in the cosmetic. In addition, the inventors' experiments have confirmed that phenoxyethanol dissolves in propylene glycol at room temperature and dissolves in butylene glycol or glycerin by raising the temperature. And even when this dissolved phenoxyethanol solution was mixed with a large amount of water, no separation or precipitation of phenoxyethanol was observed, and it was confirmed that the dissolved state in a mixed solvent of water and polyhydric alcohol was maintained. . That is, it was confirmed that phenoxyethanol is soluble in water and / or polyhydric alcohol at a predetermined ratio.

  In the water-containing composition of the present invention, as a result of various experiments conducted by the inventor, the content of phenoxyethanol is preferably in the range of 0.2% by weight to 1.0% by weight with respect to the total amount of the composition. In the above, it was found that phenoxyethanol maintains a dissolved state without being separated in the water-containing composition and exhibits excellent antiseptic properties. More desirably, the phenoxyethanol content is in the range of 0.3% to 0.8% by weight, and it has been found that sufficient antiseptic properties are exhibited even in this range of content. When the phenoxyethanol content is less than 0.2% by weight, sufficient antiseptic properties cannot be obtained. When the phenoxyethanol content exceeds 1.0% by weight, it is estimated that there is a tendency for inconvenience to human health.

At normal temperature, phenoxyethanol dissolves in water at a concentration of about 2% by weight, and is compatible with, for example, dissolved at a concentration of about 3% by weight when heated to about 50 ° C. It was confirmed. In addition, phenoxyethanol is readily soluble in polyhydric alcohols such as propylene glycol, dipropylene glycol, and butylene glycol, and is compatible with glycerin that has a high viscosity. It was confirmed that it was easily dissolved and compatible with each other. In particular, phenoxyethanol was confirmed to be easily dissolved and compatible even at room temperature in the presence of both water and polyhydric alcohol solvents.
Further, in a water-containing composition containing a crosslinkable water-soluble polymer and / or a non-crosslinkable water-soluble polymer dissolved in water and a polyhydric alcohol, and containing about 1.0% by weight of phenoxyethanol, It was confirmed that the dissolved phenoxyethanol was maintained without being separated and without being precipitated even at a low temperature of about 10 ° C.

<About the water-containing composition containing glyceryl caprylate>
In the water-containing composition of the present invention, a constitution in which the preservative other than the parabens is preferably 0.01 to 0.8% by weight with respect to the total content of glyceryl caprylate is desirable. More preferably, glyceryl caprylate is dissolved or mixed in a water-containing composition containing a polyhydric alcohol.
With this constitution, (effect i-b: glyceryl caprylate / reduced skin sensitization / excellent antiseptic property) glyceryl caprylate is contained in a polyhydric alcohol without being dissolved or separated, A water-containing composition containing a functional ingredient dissolved in water that is expected to reduce skin sensitization such as skin irritation when in contact with people with low resistance and has excellent antiseptic properties Is obtained.

  In particular, a configuration containing glyceryl caprylate as a preservative other than parabens without containing a paraben preservative is also possible. Thereby, the water-containing composition which exhibits the effect of reducing the skin sensitization as described above (effect Ib: reduced skin sensitization / excellent antiseptic property) can be obtained.

According to known literature, glyceryl caprylate is a waxy semi-solid at room temperature, becomes liquid at elevated temperature, is insoluble in water, and easily dissolves in ethanol. It has both bactericidal and emulsifying effects and is widely used in cosmetics.
Although no known data on the solubility of glyceryl caprylate in polyhydric alcohol was found, as a result of various experiments conducted by the inventors, glyceryl caprylate was insoluble in water but easily dissolved in propylene glycol. In addition, it was confirmed that high viscosity polyhydric alcohols such as dipropylene glycol, butylene glycol, and glycerin dissolve each other by raising the temperature of these polyhydric alcohols or glyceryl caprylate, and have compatibility and miscibility. That is, it was confirmed that glyceryl caprylate can be dissolved in a polyhydric alcohol. In addition, even when glyceryl caprylate dissolved in these polyhydric alcohols is mixed with a composition containing water and a water-soluble polymer dissolved in water, the phase of glyceryl caprylate such as white turbidity, separation, etc. Phenomenon of poor mixing such as poor solubility was not observed, and it was confirmed that the resulting water-containing composition maintained a well dissolved or mixed state. Separately, it was confirmed that glyceryl caprylate was dissolved or compatible with ethanol and miscible.

  As a result of the inventors conducting various experiments, the content of glyceryl caprylate is desirably in the range of 0.01 to 0.8% by weight with respect to the total amount of the composition. In this range, glyceryl caprylate is a water-containing composition. It has been found that while maintaining a dissolved state without separation in a product, it exhibits excellent antiseptic properties. More desirably, the content of glyceryl caprylate is in the range of 0.02% by weight to 0.5% by weight, and it has been found that sufficient antiseptic properties are exhibited even in the content of this range. When the glyceryl caprylate content is less than 0.01% by weight, sufficient antiseptic properties cannot be obtained. When the content of glyceryl caprylate exceeds 0.8% by weight, it is estimated that there is a tendency for inconvenience in human health.

<About the water-containing composition containing polylysine>
In the water-containing composition of the present invention, a constitution containing 0.01 to 0.8% by weight of polylysine as a preservative other than parabens can be desirably implemented. More preferably, the polylysine is dissolved or mixed in the water-containing composition.
With this structure, (effect id: paraben-free / polylysine / reduced skin sensitization / excellent antiseptic properties) polylysine is contained in water and / or polyhydric alcohol without being dissolved or separated. A water-containing composition containing water and a functional ingredient that is expected to reduce skin sensitization, such as skin irritation, in contact with skin when used by people with low skin resistance. A thing is obtained.

  In addition, it is possible to implement a configuration in which a preservative other than parabens contains a polylysine preservative without containing a paraben preservative. Thereby, the water-containing composition which exhibits the effect of suppressing skin sensitization in the above-mentioned (effect id: reduced skin sensitization / excellent antiseptic property) can be obtained.

Polylysine has a melting point of about 173 ° C., is a polyamino acid in which L-lysine, which is an essential amino acid, is connected in a straight chain, and is soluble in water. Widely used as a preservative and preservative for foods with stability and health safety.
As a result of the inventors conducting various experiments, the content of polylysine is desirably in the range of 0.01 to 0.8% by weight with respect to the total amount of the composition, and in this range, polylysine is separated in the water-containing composition. It has been found that while maintaining a dissolved state, it exhibits excellent antiseptic properties. More desirably, the polylysine antibacterial content is in the range of 0.02% to 0.5% by weight, and it has been found that sufficient antiseptic properties can be obtained even in this range of content. When the polylysine antibacterial content is less than 0.01% by weight, sufficient antiseptic properties cannot be obtained. When the polylysine antibacterial content exceeds 0.8% by weight, it is presumed that there is a tendency for inconvenience in human health.

In addition, even when a polylysine solution dissolved in water and a polyhydric alcohol such as propylene glycol, dipropylene glycol, propanediol, butylene glycol, glycerin, and sorbite liquid are mixed, no precipitation of polylysine is observed. No phenomenon such as precipitation or separation of polylysine was observed.
Furthermore, even when a polylysine solution dissolved in water is mixed with water and a composition containing a functional component dissolved in water and a polyhydric alcohol, phenomena such as white turbidity such as precipitation and separation of polylysine are recognized. However, it was confirmed that a well-dissolved state was maintained in the produced water-containing composition.

<Water-containing composition containing both phenoxyethanol and other preservatives>
In the water-containing composition of the present invention, a constitution in which the preservatives other than the parabens preferably contain both preservatives of phenoxyethanol and glyceryl caprylate and / or polylysine is desirable.
With this structure, (Effect B: Preservative synergistic effect with phenoxyethanol and other preservatives, reduced skin sensitization, excellent antiseptic properties) Preservation of both phenoxyethanol and glyceryl caprylate and / or polylysine preservatives The composition containing the agent can further reduce the content of phenoxyethanol, and can significantly reduce the content of other preservatives such as glyceryl caprylate and / or polylysine used together. Even in a composition having a small total content of water, a water-containing composition containing water and a functional component that exhibits sufficient antiseptic properties is obtained. In other words, in addition to phenoxyethanol, the composition comprising both preservatives of glyceryl caprylate and / or polylysine is superior to the use of these preservatives alone at the same preservative concentration. The effect of exhibiting antiseptic properties can be obtained.

The figure explaining an example which judges the preservative effect produced by the case where 2 types of preservatives are mix | blended with FIG. 2 is shown.
When two kinds of preservatives having antiseptic properties are contained, the antiseptic action produced thereby is roughly divided into synergistic action, additive action, and antagonism. The synergistic action is an action in which two kinds of preservatives act synergistically to further enhance the inherent antiseptic power. The additive action is an action in which the preservatives of the respective preservatives are combined. Antagonism is an action in which one preservative counteracts the preservative power of another preservative. For example, as shown in FIG. 2, phenoxyethanol and glyceryl caprylate or polylysine are determined from a graph in which the minimum preservative concentration is measured by changing the respective content ratios. According to this, the minimum preservative concentration in phenoxyethanol alone is 0.2% by weight (X point) according to Example 1 described later, and the minimum preservative concentration only in glyceryl caprylate or only polylysine is described in Example 2 and below. According to Example 3, each is 0.01 wt% (Y point), and the straight line XY connecting the X point and the Y point is drawn, and the minimum preservative concentration when both the preservatives are used together, When it is inside (below) this straight line XY (for example, S point, T point, U point), it is determined that the synergism is enhanced by the combined use of both preservatives, and on the straight line XY Is determined to have an additive action (for example, point P), and determined to be an antagonistic action for reducing both preservatives if it is outside (upper side) of line XY (for example, point R). be able to.

<About water content containing both phenoxyethanol and glyceryl caprylate preservatives>
In the water-containing composition of the present invention, the minimum content of preservatives other than parabens is phenoxyethanol content in the XY coordinates with the phenoxyethanol content as the X axis and the glyceryl caprylate content as the Y axis, relative to the total amount. In the XY coordinates where the amount is the X axis and the glyceryl caprylate content is the Y axis, the point M where the phenoxyethanol content in the X axis is 0.17 wt% and the glyceryl caprylate content in the Y axis is 0.007 wt. A configuration in which both preservatives of phenoxyethanol and glyceryl caprylate are contained so as to be in the region above the straight line MN connecting the point N which is% can be desirably implemented.
As the content of phenoxyethanol and glyceryl caprylate increases, it is estimated that there is a tendency for inconvenience to human health. Desirably, the maximum content of phenoxyethanol is 0.9% by weight or less, and the maximum content of glyceryl caprylate A constitution in which the amount is 0.8% by weight or less is desirable, and the smallest possible content in this range is desirable.

  By this constitution, (Effective ro-ab: Preservative synergistic effect of phenoxyethanol and glyceryl caprylate / reduced skin sensitization / excellent antiseptic properties) Containing both preservatives of phenoxyethanol and glyceryl caprylate According to the configuration, the content of phenoxyethanol can be reduced, and the content of glyceryl caprylate used in combination can be significantly reduced. Even in a composition having a low total content of preservatives, sufficient antiseptic properties can be obtained. A water-containing composition comprising a water-containing composition containing water and a functional component is obtained. In other words, in addition to phenoxyethanol, the constitution comprising both preservatives with glyceryl caprylate has the effect of exhibiting superior antiseptic properties compared to the single use of these preservatives at the same preservative concentration. can get.

  In particular, it is also possible to implement a structure containing both phenoxyethanol and glyceryl caprylate preservatives without containing parabens. As a result, a water-containing composition that exhibits the effect of reducing the skin sensitization as described above (effect ro-ab: antiseptic synergistic effect / reduced skin sensitization / excellent antiseptic property) can be obtained.

<About a water-containing composition containing both phenoxyethanol and polylysine preservatives>
In the water-containing composition of the present invention, the minimum content of preservatives other than parabens is the phenoxyethanol content in the XY coordinates where the phenoxyethanol content is the X axis and the polylysine content is the Y axis relative to the total amount. In the XY coordinates where the X axis is the polylysine content and the Y axis, the point M where the phenoxyethanol content in the X axis is 0.17 wt% and the point N where the polylysine content in the Y axis is 0.007 wt% A configuration in which both phenoxyethanol and polylysine preservatives are contained can be desirably implemented so as to be in a region above the straight line MN connecting the two.
As the content of phenoxyethanol and polylysine increases, it is estimated that there is a tendency for inconvenience to human health. Desirably, the maximum content of phenoxyethanol is 0.9% by weight or less, and the maximum content of polylysine is 0.00. The composition of 8% by weight or less is desirable, and the smallest possible content in this range is desirable.

By this configuration, (effect ro-ad: combined use of phenoxyethanol and polylysine antiseptic synergies / reduced skin sensitization / excellent antisepticity) It is possible to reduce the content of polylysine used in combination, and it is possible to significantly reduce the content of polylysine used together, and water and functionality exhibiting sufficient antiseptic properties even in a composition having a small total content of preservatives contained. A water-containing composition comprising a water-containing composition containing the components is obtained. In other words, in addition to phenoxyethanol, the composition comprising both preservatives with polylysine provides an effect of exhibiting superior antiseptic properties compared to the single use of these preservatives at the same preservative concentration. .
Moreover, the structure which contains the preservatives of both phenoxyethanol and the polylysine antiseptic | preservative is also possible, without containing parabens. As a result, a water-containing composition that exhibits the effect of reducing the skin sensitization as described above (effect load: antiseptic synergistic effect / reduced skin sensitization / excellent antiseptic property) can be obtained.

<About a water-containing composition containing a plurality of preservatives of phenoxyethanol, glyceryl caprylate and polylysine>
In the water-containing composition of the present invention, the minimum content of preservatives other than parabens is XY coordinates with the phenoxyethanol content as the X axis and the total content of glyceryl caprylate and polylysine as the Y axis relative to the total amount. In the XY coordinates where the phenoxyethanol content is the X axis and the total content of glyceryl caprylate and polylysine is the Y axis, the point M where the phenoxyethanol content in the X axis is 0.17% by weight and the glyceryl caprylate in the Y axis And a composition containing both preservatives of phenoxyethanol, glyceryl caprylate and polylysine so as to be in a region above the straight line MN connecting point N having a total polylysine content of 0.007% by weight. It can be implemented.
With this configuration, (effective ro-abd: combined use of phenoxyethanol, glyceryl caprylate and polylysine, antiseptic synergy, reduced skin sensitization, and excellent antiseptic properties) In the composition containing, the content of phenoxyethanol can be reduced, the content of polylysine and glyceryl caprylate used together can be significantly reduced, and even in a composition with a low total content of preservatives contained. A water-containing composition provided with a water-containing composition containing water and a functional component that exhibits sufficient antiseptic properties is obtained. In other words, in addition to phenoxyethanol, the constitution comprising both polylysine and glyceryl caprylate preservatives has the effect of exhibiting superior antiseptic properties compared to the single use of these preservatives at the same preservative concentration. Is obtained.

  Desirably, a configuration comprising a plurality of preservatives of phenoxyethanol, glyceryl caprylate, and polylysine preservatives without containing parabens can be implemented. As a result, a water-containing composition that exhibits the effect of reducing the skin sensitization as described above (effect ro-abd: antiseptic synergistic effect / reduced skin sensitization / excellent antiseptic property) can be obtained.

<About a water-containing composition containing a preservative other than parabens and 0.05 wt% or less of parabens>
In the water-containing composition of the present invention, in addition to the preservatives other than parabens, the water-containing composition can further comprise (F) 0.05% by weight or less of parabens based on the total amount. .
Parabens have the property of being hardly soluble in water and soluble in polyhydric alcohol, but in this configuration, parabens are contained in a form dissolved in a water-containing composition having water and polyhydric alcohol. The
With this composition, (effect C: parabens decreased / reduced skin sensitization / excellent antiseptic), parabens that have been reported to have skin sensitization are contained in a very small amount compared to conventional ones, and phenoxyethanol In combination with other preservatives such as glyceryl caprylate and polylysine, the skin sensitization is reduced by significantly reducing parabens and the content of other preservatives is also significantly reduced. Even when used by a person with low resistance, it is expected to reduce skin sensitization such as skin irritation on contact, and a water-containing composition that exhibits excellent antiseptic properties can be obtained.

Since parabens have skin sensitization, compositions containing no parabens are most desirable, however, in addition to compositions containing preservatives other than parabens such as phenoxyethanol, glyceryl caprylate, polylysine, etc. A composition containing as little parabens as possible is also feasible, whereby a water-containing composition with reduced skin sensitization is obtained.
Because the skin sensitization varies depending on the person who uses the paraben preservative, it is not possible to define an acceptable content of a clear paraben preservative. If the content of the paraben preservative exceeds 0.05% by weight, the skin sensitization tends to occur.
In the composition containing 0.05% by weight or less of parabens to reduce skin sensitization with respect to the total amount, and containing a preservative other than the above parabens, an antiseptic other than the above parabens Excellent antiseptic properties can be obtained even in a composition in which the minimum content of preservatives other than the above-mentioned parabens is reduced as compared with a composition containing an agent alone. When the preservative other than parabens is phenoxyethanol, the minimum content of 0.2% by weight can be reduced to a minimum content of 0.1% by weight, and 0.01% when glyceryl caprylate is used. The minimum content of wt% can be reduced to a minimum content of 0.005 wt%, and if polylysine, the minimum content of 0.01 wt% can be reduced to a minimum content of 0.005 wt% And excellent antiseptic properties can be obtained.

<Dissolved state of preservative contained in water>
In the water-containing composition of the present invention, a constitution in which the preservative is contained in a state dissolved in the water-containing composition can be desirably implemented.
With this configuration, the effects “Effect I”, “Effect B”, and “Effect C” are more remarkably exhibited. (Effect Iroha: Reducing and reducing the content of the preservative by dissolving the preservative contained) (Skin sensitization / excellent antiseptic properties) In a water-containing composition containing other preservatives other than parabens, the content of the preservative is significantly reduced by being contained in a dissolved state. Even if the composition is used, it contains water and water-soluble polymers that are expected to reduce skin sensitization, such as skin irritation, when touched by people with low skin resistance, as well as having excellent antiseptic properties. A water-containing composition is obtained. In particular, when people with low skin resistance, such as infants and the elderly, use it, significant improvement in skin sensitization such as skin irritation can be expected.

<About the configuration in which the functional component is a water-soluble polymer>
In the water-containing composition of the present invention, the functional component is a water-soluble polymer that is soluble in water, and the water-soluble component is dissolved in the water, and water, water-soluble polymer, polyhydric alcohol, and The antiseptics other than parabens can be desirably implemented in a state where they are dissolved or compatible with each other.

As the water-soluble polymer as the functional component, the following cross-linkable water-soluble polymer and / or non-cross-linkable water-soluble polymer can be used.
(A) It contains a crosslinkable water-soluble polymer that can be cross-linked to a network structure in terms of molecular structure, and at about room temperature of about 18 to about 30 ° C., the crosslinkable water-soluble polymer is in a state where a crosslinking agent is present. And a non-flowable gel that is cross-linked in a dissolved state in water.
(B) It contains a crosslinkable water-soluble polymer that can be cross-linked into a network structure in terms of molecular structure, and the crosslinkable water-soluble polymer is in the absence of a cross-linking agent in the vicinity of room temperature of about 18 to about 30 ° C. It has a fluid viscous shape that is not cross-linked when dissolved in water.
(C) It contains a non-crosslinkable water-soluble polymer that is not cross-linked in terms of molecular structure, and the non-crosslinkable water-soluble polymer is not cross-linked in a dissolved state in water at around room temperature of about 18 to about 30 ° C. It has a fluid and viscous shape.
(D) a water-soluble polymer having both a crosslinkable water-soluble polymer that can be cross-linked to a network structure in molecular structure and a non-cross-linkable water-soluble polymer that is not cross-linked in molecular structure; In the vicinity of a normal temperature of 0 ° C., the crosslinkable water-soluble polymer has a non-flowable water-soluble polymer that is cross-linked in a state dissolved in water in the presence of a cross-linking agent. The polymer has a fluid viscous state that is not cross-linked when dissolved in water.

<Crosslinkable water-soluble polymer>
The crosslinkable water-soluble polymer is soluble in water before cross-linking and has fluidity dissolved in water, and after cross-linking, is dissolved in water and / or contains water. And, it has the property of becoming a gel that is in a state without fluidity. The crosslinkable water-soluble polymer has a property that it can be crosslinked in a molecular structure to a network structure by a chemical reaction with a crosslinking agent.
The crosslinkable water-soluble polymer is not particularly limited. For example, (i) acrylic acid, methacrylic acid, and at least one acrylic monomer based on these monovalent metal salts are polymerized. (Ii) (a) acrylic acid, methacrylic acid, and at least one acrylic monomer of these monovalent metal salts, and (b) alkyl acrylate. And a cross-linked acrylic acid copolymer obtained by copolymerizing at least one alkyl acrylate monomer of alkyl methacrylate and (iii) in a partially neutralized polyacrylic acid Japanese type polyacrylic acid, (iv) crosslinked carboxyvinyl polymer, and (v) sodium carboxyalkyl cellulose and / or hydroxyalkyl cellulose Crosslinked cellulosic compounds of helium, (the alkyl group include a methyl group, an ethyl group, Purobiru etc. groups) at least one crosslinkable water-soluble polymer is carried out is selected from the group consisting of.
As the partially neutralized polyacrylic acid, partially neutralized sodium polyacrylate is used in which a part of the carboxylic acid group of polyacrylic acid is neutralized with a monovalent ion such as sodium.

  With this configuration, the above-mentioned (Effect: Reduced skin sensitization / excellent antiseptic properties) can be obtained, and (Effect D: Comfortable water-retaining and flexible shape-retaining property and reduction due to inclusion of a crosslinkable water-soluble polymer) (Skin sensitization / excellent antiseptic properties) By containing a crosslinkable water-soluble polymer, the crosslinkable water-soluble polymer dissolved in water is cross-linked into a network structure in the molecular structure by a chemical reaction with the cross-linking agent. Water structure that changes from a fluid state to a non-flowable gel state, has no fluidity, can retain its shape against external pressure, and retains a sufficient amount of water Therefore, when it adheres to human skin, the effect of changing the state to a gel-like water-containing composition that has a comfortable water-retaining and flexible shape-retaining property and is prevented from flowing out is obtained.

The crosslinkable water-soluble polymer is easily dissolved in water, and the crosslinkable water-soluble polymer dissolved in water becomes a water-containing crosslinkable water-soluble polymer sufficiently retaining a large amount of water, and has a viscous viscosity. It has the property of becoming a viscous liquid. The water-containing crosslinkable water-soluble polymer reacts chemically when mixed with a crosslinking agent in a state dissolved in water, and is cross-linked into a network structure in the chemical structure, has no fluidity, and retains. It changes to a gel-like water-containing composition having shape, water retention and flexibility. The water-containing composition is in a form having a predetermined amount of bound water, dissolved water, and free water.
The molecular weight of the cross-linkable water-soluble polymer is not particularly limited, but a cross-linkable water-soluble polymer having a molecular weight of about 10,000 to about 10 million is used, but the viscosity when dissolved in water as the molecular weight increases. However, the crosslinking density of the crosslinkable water-soluble polymer is not particularly limited, but the crosslinking density increases as the crosslinking density increases. The water-holding flexible shape-retaining property of the water-containing composition tends to be hard, and the type of cross-linkable water-soluble polymer having a desired molecular weight and cross-linking density corresponding to the desired comfortable water-holding shape-retaining property, and cross-linking The type of agent is selected and used.

  As the content of the crosslinkable water-soluble polymer increases, the effect of maintaining the shape retention of the gel-like water-containing composition formed by the crosslinking chemical reaction increases and the water retention is improved. When the content of the polymer is too large, the water-retaining and flexible shape-retaining property tends to be hard, and when it is applied to the human skin, there is a tendency to feel uncomfortable sticking. As the content of the crosslinkable water-soluble polymer decreases, the shape retaining property of the gel that maintains the shape against external pressure decreases and the water retention also decreases, and the content of the crosslinkable water soluble polymer is too small. In some cases, the effect of changing the state of the gel-like water-containing composition capable of maintaining the shape retention of the gel tends to be reduced.

<About cross-linking agent>
Although it does not specifically limit as a crosslinking agent, For example, polyvalent metal ionic compounds, such as magnesium, calcium, zinc, aluminum, aluminum hydroxide, aluminum chloride, aluminum sulfate, aluminum hydroxide magnesium, aluminum hydroxide potassium, Aluminum potassium sulfate (also known as alum), magnesium metasilicate aluminate, aluminum glycinate (also known as dihydroxyaluminum aminoacetate, glycine aluminum), magnesium metasilicate aluminate, aluminum nitrate, aluminum sulfate, aluminum acetate, etc. Two or more arbitrarily combined crosslinking agents can be used.
Such polyvalent metal ionic compounds react chemically with the carboxylic acid or carboxylic acid ion of the crosslinkable water-soluble polymer dissolved in the medium, and have a network structure and no fluidity. It has the action of forming a gel-like water-containing composition having shape retention, water retention and flexibility.

  Although content of a crosslinking agent is not specifically limited, For example, it is 0.001-1 weight%, Preferably it is 0.005-0.5 weight%. When the content of the cross-linking agent is less than 0.001, the cross-linking reaction of the cross-linkable water-soluble polymer becomes incomplete, and the desired gel strength of the water-containing composition and the comfortable water-holding flexible shape-retaining property cannot be obtained. Tend. When the content of the cross-linking agent exceeds 1% by weight, a water-containing composition in which the unreacted cross-linking agent remains is obtained, and an unexpected adverse effect may occur on the contrary without obtaining any benefit.

<About non-crosslinkable water-soluble polymer>
The non-crosslinkable water-soluble polymer has a function of imparting or controlling flexibility, adhesiveness, and / or easy peelability when configured in a patch.
As the non-crosslinkable water-soluble polymer, a polymer material that is easily soluble in water is applied, and is not particularly limited. For example, polyvinyl alcohol, polyethylene glycol, polypropylene glycol, starch acrylate, polyalkyl acrylate, polyvinyl Pyrrolidone, copolymerized polymer of alkyl acrylate and secondary monomer, non-crosslinked cellulose, gelatin, agar, etc. can be applied.
As polyalkyl acrylate, for example, polyethyl acrylate, polybutyl acrylate, polyethyl hexyl acrylate, octyl polyacrylate, decyl polyacrylate, and the like can be used. As a secondary monomer copolymerized with alkyl acrylate, for example, vinyl acetate, methyl methacrylate, maleic anhydride, hydroxyethyl acrylate and the like can be used. As the non-crosslinked cellulose, carboxyalkyl cellulose, hydroxyalkyl cellulose and the like can be used.

  Other water-soluble polymers include hyaluronic acid, alginic acid, sodium alginate, carrageenan, glucomannan, xanthan gum, guar gum, juran gum, Ernest gum, locust bean gum, pectin, agarose, dextrin, glucomannan, polyglutamic acid, polyglutamic acid. Salts, partially neutralized products of polyglutamic acid, alginic acid, alginic acid salts and the like can also be carried out.

  These non-crosslinkable water-soluble polymers are soluble in water or have a good compatibility with water, and are characteristic of each non-crosslinkable water-soluble polymer. And a water-containing composition having desired viscosity, flexibility, adhesiveness, easy-peeling adhesiveness, residual adhesive controllability after peeling, etc., corresponding to the characteristics of the non-crosslinkable water-soluble polymer You can get things. For example, gelatin, collagen, agar, etc. have the property of suppressing adhesiveness, and when configured as a patch, they are used as post-peeling residual adhesive inhibitors that control easy peeling adhesiveness and residual adhesiveness after peeling. Works.

  As the content of the non-crosslinkable water-soluble polymer increases, it becomes possible to retain a large amount of sufficient water, and the soft consistency that increases the flexibility and viscosity improves, but the non-crosslinkable water-soluble polymer When there is too much content, there exists a tendency for it to become hard in a softness | flexibility.

  With this configuration, the above-mentioned (effect i: reduced skin sensitization / excellent antiseptic properties) can be obtained, and (effect e: comfortable water retention soft adhesive due to inclusion of non-crosslinkable water-soluble polymer) water Non-crosslinkable water-soluble polymer dissolved in water has water retention capacity that can retain a large amount of moisture, and has comfortable flexibility and adhesion when attached to or stuck to human skin. The effect which has water retention soft adhesiveness is acquired.

  In particular, in a patch provided with the water-containing composition of the present invention, (Effect: Easy peeling due to inclusion of non-crosslinkable water-soluble polymer / residue suppression after peeling), non-crosslinking water-soluble high By selecting and containing gelatin, agar, etc. that can suppress adhesiveness as molecules, an appropriate pressing force can be obtained in a composition containing at least a crosslinkable water-soluble polymer, water, and a non-crosslinkable water-soluble polymer. To stick to the human skin and stick or stick tack when sticking, sticking to the extent that it is difficult to peel off during daily use during sticking, damage to the skin when peeling from the skin A water-containing composition that is easily peelable and can be peeled off without giving any significant discomfort or irritation to the skin, and when a patch containing a water-containing organism attached to the skin is removed from the skin. Part patch is obtained having a degree of exfoliation after residue inhibitory no remaining adhered to the skin, the easy-peeling adhesive and peeling after residue inhibiting effect that combines.

  These non-crosslinkable water-soluble polymers are soluble in water and have the property of increasing the viscosity of the water-containing composition, while water-containing compositions containing these non-crosslinkable water-soluble polymers When a patch comprising a patch is applied to human skin and the water-containing composition applied to the skin is peeled off from the skin after a certain period of time, the water-containing composition remaining on the skin can be suppressed. Have

<About a water-containing composition in a state in which it does not contain a crosslinking agent and is not crosslinked in a composition containing a crosslinkable water-soluble polymer>
In the composition containing the crosslinkable water-soluble polymer, a structure not containing a crosslinking agent can also be implemented. In this case, the crosslinkable water-soluble polymer is not cross-linked, has a fluidity at a temperature higher than normal temperature, and has a gel state with no fluidity due to a decrease in temperature. It has a similar effect to a non-crosslinkable water-soluble polymer.
That is, in the water-containing composition, the water-soluble polymer contains a cross-linkable water-soluble polymer that can be cross-linked molecularly, and does not contain a cross-linking agent that can cross-link the cross-linkable water-soluble polymer structurally. The crosslinkable water-soluble polymer includes the above-mentioned (i) crosslinkable acrylic acid polymer, (ii) crosslinkable acrylic acid copolymer, (iii) crosslinkable carboxyvinyl polymer, and (iv) crosslinkable cellulose. At least one cross-linkable water-soluble polymer selected from the group consisting of compounds, which are contained in a non-cross-linked state, and flow in a temperature range higher than about 50 ° C. and fluid at a temperature of about 45 ° C. or lower. It is also possible to implement a configuration having a gel-like shape without any other.

  With this configuration, the above-mentioned (effect i: reduced skin sensitization / excellent antiseptic properties) can be obtained, and similar to the above-mentioned (effect e), (effect e-1: contained without being crosslinked) Comfortable water-retaining and soft-adhesive due to the inclusion of the cross-linkable water-soluble polymer) By containing the non-cross-linkable water-soluble polymer dissolved in water, it has a water retention property capable of holding a large amount of water and human skin A water-containing composition having a comfortable water-holding and flexible adhesive property that has a comfortable flexibility and adhesiveness when attached to or attached to the surface is obtained.

  The crosslinkable water-soluble polymer dissolved in water is in a fluid state at a high temperature, but tends to become a non-fluidic gel as the temperature decreases, and the boundary temperature is included. It varies depending on the type and content of the crosslinkable water-soluble polymer, and is not clear. For example, it has fluidity at a temperature of about 50 ° C. or higher and becomes non-flowable gel at a temperature of about 45 ° C. or lower. A structure containing a crosslinkable water-soluble polymer is desirable.

<About change of fluidity with temperature of water-containing composition containing water-soluble polymer>
In a water-containing composition containing water and a water-soluble polymer, regardless of whether the water-soluble polymer is a crosslinkable water-soluble polymer or a non-crosslinkable water-soluble polymer, the water-containing composition exhibits fluidity at high temperatures. It has a property of becoming a gel with no fluidity as the temperature becomes lower.
In particular, when the water-soluble polymer is a cross-linkable water-soluble polymer and contains a cross-linking agent, the cross-linkable water-soluble polymer is gradually cross-linked into a network structure in the molecular structure by a chemical reaction with the cross-linking agent. It becomes a gel with no fluidity. The water-containing composition containing the crosslinkable water-soluble polymer having a cross-linked network structure has a gel shape having no fluidity even at a high temperature, and maintains the gel shape having no fluidity even at a low temperature. .
On the other hand, in the case of a composition containing a non-crosslinkable water-soluble polymer and / or a crosslinkable water-soluble polymer that does not contain a crosslinking agent, the composition is fluid at high temperatures, As it becomes, it becomes a non-fluid gel.

<Regarding the efficacy-imparting functional component as the functional component contained in the water-containing composition>
The functional components contained in the water-containing composition are the above-mentioned various water-soluble polymers and / or functional components that are effective, and the functional components that are functional include pharmacologically active components, skin-improving components, and aromas. A configuration that is at least one selected from the group consisting of components is desirable and can be implemented.
In the water-containing composition of the present invention, the composition containing a water-soluble polymer as the above-mentioned functional component, or further containing a functional component that imparts an effect in addition to the water-soluble polymer contained as the functional component Or a water-containing composition having a constitution such as a constitution containing an effect-imparting functional component without containing a water-soluble polymer.
The effect-imparting functional component is contained in a state dissolved in the water-containing composition, a state contained in the water-containing composition in an emulsified state, or a state in which these fine particles are dispersed and contained.

  The pharmacologically active ingredient is not particularly limited.For example, indomethacin, loxoprofen, ketoprofen, diclofenac, diclofenac sodium, felbinac, piroxicam, suprofen, ibuprofen, ketorolac, lidocaine, flurbiprofen, mefenamic acid, dipotassium glycyrrhizinate, salicylic acid Analgesic / anti-inflammatory agents such as esters, antipruritic agents, emollients, hair agents, bath agents, and other skin agents can be used.

  The skin improvement component is not particularly limited, but, for example, tocopherols such as tocopherol acetate, placenta extract, hyaluronic acid, econzyme, arbutin, collagen, polyphenols, allantoin, squalane, panthenol, chamomile extract, hamamelis extract, Lavender extract, pearl barley extract, buckwheat extract, rice extract, salmon ovary extract, saccharomyces, rice fermentation broth, vitamin Cs, vitamin Es, and other vitamins can be used. Such a water-containing composition containing a skin-improving ingredient is applied to, attached to, or affixed to the skin of a human face, etc. Effects such as removal / reduction of skin, improvement of skin wrinkles, moisturization of skin, and the like.

  Although it does not specifically limit as an fragrance component which generate | occur | produces fragrance, For example, the essential oil component (essential oil) generally used for aromatherapy can be used. Examples of the fragrance component include those described in Wonder Cellar “84 essential oil components for aromatherapy” and Fragrance Journal. For example, Anise, Angelica, Benzo, Immortelle, Chamomile, Garlic, Cardamom, Galvanam, Caraway, Carrot Seed, Guayac Wood, Grapefruit, Cybless, Cedarwood, Star Anise, Sage, Geranium, Celery, Thyme, Tarragon, Terpin, Nintense, Violet, Pine, Parsley, Fennel, Black Peppa, Bodaige Flower, Lemon, Lemongrass, Rosemary, Laurel, Shimotakekuk, Shimosukeso, Cornflower, Almond, Arnica, Fennel, Enishida, Watercress, Gentian, Ganoderma, Plum, Pear , Dandelion, Chimo, Chorei, Capsicum, Neubara, Hakka, Tonerico, Bucurio, Melissa, Peach, Mistletoe, Eucalyptus, Yokuinin, Rabe Da, there may be mentioned extracts from forsythia, and the like otherwise thereto.

  (Effectiveness) Functionality-providing functionality contained by applying, adhering or sticking a water-containing composition containing a functionality-functionality component to the human skin such as the forehead, heel, neck, limbs, etc. of the human body In response to pharmacological activity, such as analgesic / anti-inflammatory, anti-pruritic, etc., and whitening / facial removal, skin freckles removal / reduction, skin wrinkle improvement, skin moisturizing, skin improvement, isopotency-improving effect Can be played.

<Additional components contained in water-containing composition>
The water-containing composition of the present invention further contains an additional component, and when the additional component is contained in the mouth (K-1), the anti-eating component having a function of feeling bitter and suppressing accidental eating, K-2) A cooling sensation imparting component that produces a refreshing sensation, (K-3) a warm sensation imparting component that produces a warm sensation, and (K-4) a pH adjusting component that adjusts pH. A configuration containing at least one additional component is also feasible.

Anti-corrosive ingredient is desodium benzoate, refreshing ingredient is menthol and / or peppermint oil, warm feeling ingredient is capsaicin and / or pepper ingredient, pH adjusting ingredient is not particularly limited and citric acid General purpose acidic substances or alkaline substances such as acetic acid, tartaric acid and sodium hydroxide can be used.
As an anti-eating agent, desodium benzoate is effective, and by containing a small amount of de-sodium benzoate, it has a function of feeling bitter when it is contained in the mouth and suppressing eating error.
Desodium benzoate is a solid powder having a melting point of about 166 to 170 ° C., has a property of being dissolved in water or ethanol, and is contained in a state dissolved in a water-containing composition. When a composition containing a trace amount of desodium benzoate is included in the mouth, it has a property of feeling strong bitterness. When the water-containing composition containing desodium benzoate is mistakenly put in the mouth, a strong bitter feeling is felt. In this structure, (Effect H) A water-containing composition containing desodium benzoate has the effect of suppressing bitterness when it is contained in the mouth, and has the effect of suppressing accidental eating. When using people with weak health resistance, the effect of suppressing accidental eating is obtained.

As the refreshing feeling imparting component, for example, menthol, mint oil, and brains can be used.
As the warmth imparting component, for example, capsaicin, red pepper extract or red pepper powder can be used.

<About other additives contained in the water-containing composition>
In the water-containing composition of the present invention, in order to obtain the desired performance in the adhesiveness, flexibility, water retention, shape retention, easy peeling adhesiveness, post-peeling residue suppression, etc. of the water-containing composition, In addition to functional components such as water, water-soluble polymers, polyhydric alcohols and prescribed preservatives, there are also tackifiers, softeners, moisturizers, plasticizers, colorants, skin absorption promoters, antioxidants Containing additives such as UV absorbers, inorganic fillers, surfactants, stabilizers, viscosity modifiers, inorganic fillers, fine powders, silicone oils, pH adjusters, and other additive aids Can also be implemented.

Examples of tackifiers include rosin, hydrogenated rosin, rosin ester, hydrogenated rosin ester, polyterpene, terpene phenol, phenol resin, xylene resin, coumarone indene resin, other aliphatic resins (C5 resins), petroleum Resin, alicyclic hydrocarbon resin (hydrogenated aromatic resin) and the like can be used.
Softeners and plasticizers include polybutene, polyisobutylene, dioctyl phthalate, dibutyl phthalate, diethyl phthalate, liquid rosin ester, chlorinated paraffin, process oil, lanolin, silicone, petrolatum, solid paraffin, liquid paraffin, plaster pace, beeswax , Menthol, limonene, pinene, piperiton, terpinol, carveol, almond oil, olive oil, camellia oil, persic oil, mint oil, sesame oil, soybean oil, mink oil, cottonseed oil, corn oil, safflower oil, grape oil, macadamia nut oil, Egg yolk oil, safflower oil, etc. can be used.

As the colorant, dyes and pigments commonly used in the cosmetic field can be used.
The inorganic filler, fine powder, and the like are not particularly limited. For example, silica, kaolin, talc, titanium oxide, mica, silicone powder, charcoal powder, and the like can be used.

The pH adjuster is not particularly limited, but examples thereof include organic acids such as citric acid, succinic acid, tartaric acid, lactic acid, malic acid, acetic acid, gluconic acid, maleic acid, sodium salts or potassium salts of these organic acids, Hydrochloric acid, sulfuric acid, sodium hydroxide, potassium carbonate, sodium bicarbonate, calcium chloride, diisopropanolamine, etc. are used.
In order to contain such a pH adjuster so as not to adversely affect the skin, the pH of the water-containing composition is adjusted to the range of 4 to 10, desirably the range of pH 5 to 9, more preferably , PH is adjusted to a range of 6-8.

As a stabilizer, sodium pyrosulfite, magnesium aluminate metasilicate, vanillyl nonanoic acid, sodium edetate, and the like can be used.
As the surfactant, various polysorbates, polyoxyethylene sorbitol tetraoleate, polyoxyethylene lauryl ether, polyethylene glycol laurate, and the like can be used.

  Other additive aids include lanolin, liquid paraffin, beeswax, limonene, pinene, piperiton, terpinol, carveol, jojoba oil, almond oil, olive oil, camellia oil, persic oil, mint oil, sesame oil, soybean oil, mink oil, cottonseed oil Corn oil, safflower oil, grape oil, macadamia nut oil, egg yolk oil, safflower oil, etc. can be used. As the silicone oil, methylsiloxane, methylphenylpolysiloxane, dodecamethylpolysiloxane and the like can be used.

In the present invention, the water-containing composition may further comprise a lower alcohol such as ethanol and / or propyl alcohol, and / or a surfactant. Such a lower alcohol or surfactant is used as a solubilizing agent for facilitating dissolution or uniform dispersion of functional components, additional components, preservatives, or other additives. For example, in the step (d) of FIG. 1, the additional component is used by being dissolved in water, a polyhydric alcohol, a lower alcohol and / or a surfactant.
When pharmacologically active ingredients, skin-improving ingredients, functional ingredients such as aromatic ingredients, refreshing ingredients, additional ingredients such as anti-corrosion ingredients, preservatives, and other additives cannot be dissolved in water or polyhydric alcohols Contains a minimum amount of lower alcohol or surfactant and dissolves or emulsifies these functional ingredients, additional components, and other additives in a water-containing composition, and uniformly contains them It is possible to prepare a hydrated water-containing composition. Using functional ingredients, additional ingredients, preservatives, and other additives containing lower alcohols or surfactants to prepare dissolved or homogeneously dispersed functional ingredients / additional ingredients, etc. Mixing a solution containing the functional component / additional component with a composition containing polyhydric alcohol-water, thereby preparing a water-containing composition containing the functional component / additional component uniformly. Can do. The content of lower alcohols such as ethanol and propyl alcohol is preferably about 10 weight percent or less based on the total weight of the water-containing composition. When the content of the lower alcohol exceeds about 10 weight percent, these lower alcohols tend to evaporate, so when they adhere to the human skin, they evaporate and feel an unpleasant alcohol odor, or the evaporated lower alcohol Tends to adversely affect the human body.

  Although it does not specifically limit as surfactant used, For example, the liquid surfactant which has a function as a solvent while being liquid at normal temperature or a slight temperature rise can be used. For example, glycerin fatty acid ester, alkyl polyoxyethylene glycol, ponoxyethylene alkyl phenyl ether (alkyl group is octyl group, etc.), alkyl glycoside (alkyl group is octyl group, decyl group, dodecyl group, etc.), sorbitan fatty acid ester ( Nonionic surfactants having a fatty acid group such as monolauric acid, monostearic acid, tristearic acid, oleic acid, tetraoleic acid and the like can be used.

<Cosmetics and external medicines with water-containing composition>
Patches, cosmetics or external medicines with a water-containing composition can be implemented.
As a patch, a cooling sheet that cools the forehead of a human body having a configuration in which the water-containing composition of the present invention is held by a sheet-like holding member, an analgesic / anti-inflammatory patch, and a skin improvement agent that improves the skin condition of the face, etc. A pack sheet or a face mask can be implemented.
As cosmetics or topical pharmaceuticals, for example, it has a water-containing composition having the constitution of the present invention, and has a liquid, spray, cream, emulsified, gel-like form, and is applied to, adhered to, or stuck to the skin. Cosmetics and skin drugs to be applied can be implemented.

<About patches with a water-containing composition>
The water-containing composition containing a water-soluble polymer as a functional component contained in the water-containing composition is attached to and / or impregnated on the sheet-like holding member, and is contained in the water-containing composition. The component contains a water-soluble polymer that can be dissolved in water, and is formed so that it can be applied to the human skin, and an antiseptic patch can be implemented.

A patch in which a water-containing composition is held on a sheet-like holding member is used by being affixed to human skin, exhibits a desired effect during use, and is peeled off from human skin after use.
Attached to the human skin for the purposes of cooling effect, warming effect, cooling effect, analgesic effect, anti-inflammatory effect, skin whitening effect, skin wrinkle improving effect, other pharmacological effects, etc. The agent is required to exhibit the following excellent antiseptic properties (a) and to have the desired performance as patches (b) to (f) below in an optimal balance.
(A) Antiseptic properties in which spoilage due to bacteria during storage is prevented.
(B) A sense of incongruity such as a hard sensation is suppressed, and it is easy to adhere to human skin and is soft and supple.
(C) The shape retention property that maintains the shape without causing the water-containing composition attached to or affixed to the skin to flow or break.
(D-1) Adhesive or tack adhesive when sticking and sticking to human skin with appropriate pressing force, (d-2) Adhesiveness that is difficult to peel off in daily operations while using adhesive And (d-3) easy-peeling adhesive that can be peeled off without damaging the skin and without causing any significant discomfort or irritation to the skin when peeled from the skin.
(E) Residual property suppression after peeling to such an extent that a part of the water-containing composition does not adhere to the skin when the water-containing composition attached to or stuck to the skin is peeled off from the skin.
(F) A water-containing composition having a water-retaining and flexible shape-retaining property having water retention property that hardly causes transpiration of water in addition to flexibility and shape-retaining property, and a patch comprising the water-containing composition.

In such a patch, in order to obtain the basic performance as a desired patch, as a functional component contained in the water-containing composition, a crosslinkable water-soluble polymer and a molecule that can be crosslinked in a molecular structure into a network structure. A patch having a water-soluble polymer and a non-crosslinkable water-soluble polymer that is not structurally crosslinked, and has flexibility and tackiness at a temperature of about 45 ° C. or less and is not fluid. A patch that has gel-like shape retention, has antiseptic properties, and is applied to human skin can be used.
The crosslinkable water-soluble polymer has fluidity until it is cross-linked by a chemical reaction in the presence of a cross-linking agent, and is non-flowable after being cross-linked by a chemical reaction with the cross-linking agent. The non-crosslinkable water-soluble polymer having a gel form has a fluid viscosity that is dissolved in water and not crosslinked.

  The water-containing composition provided in the patch has fluidity before adhering to and / or impregnating the sheet-like holding member, and about 45 ° C. or less after adhering and holding the sheet-like holding member. A composition having a gel shape that is flexible and sticky at a temperature of no fluidity can be used, and in order to exhibit this property, a crosslinkable water-soluble polymer that can be crosslinked in a desired molecular structure, In addition, non-crosslinkable water-soluble polymers that cannot be crosslinked are used.

In the case of a composition containing a crosslinkable water-soluble polymer and a cross-linking agent, the crosslinkable water-soluble polymer is used as a method for producing a patch having a structure in which the water-containing composition is held on a sheet-like holding member. This fluid water-containing polymer composition is adhered and / or impregnated and retained in a predetermined shape on the sheet-like holding member when it has a fluidity that is not cross-linked, and then, in the course of time, the cross-linkable water-soluble polymer composition A molecule | numerator is bridge | crosslinked and a fluid hydrous polymer composition will be in a gel state without fluidity | liquidity. In this way, a patch is produced in which the gel-like water-containing composition is adhered and held and / or impregnated and held on a cheat-like holding member. In this case, the temperature of the fluid hydrous polymer composition is not particularly limited, and can be any temperature such as low temperature, normal temperature, and high temperature.
For example, a flowable water-soluble polymer composition having a fluidity at a low temperature is attached and / or impregnated and held in a predetermined form on a sheet-like holding member, and then crosslinkable water-soluble polymer over time until reaching room temperature. Can be carried out in a gel state having no fluidity.
Further, the flowable water-containing polymer composition is attached to and held in a predetermined form on a sheet-like holding member at a low temperature or normal temperature having fluidity, and then heated to a predetermined temperature to be crosslinked water-soluble polymer. Can be carried out in a gel state having no fluidity.

  In the case of a composition containing a crosslinkable water-soluble polymer or a non-crosslinkable water-soluble polymer that does not contain a crosslinking agent, it flows in a temperature range higher than about 50 ° C. and at a temperature of about 45 ° C. or lower. The types, contents, and the like of these water, water-soluble polymer, and polyhydric alcohol are prepared as desired so as to have a non-flowable gel.

The crosslinkable water-soluble polymer and non-crosslinkable water-soluble polymer contained in the water-containing composition constituted in the patch are the same cross-linkable water-soluble polymers as the water-soluble polymer described in the above-mentioned water-containing composition section. Polymers and non-crosslinkable water soluble polymers are included.
That is, as the crosslinkable water-soluble polymer, (i) a crosslinkable acrylic acid polymer, (ii) (a) an acrylic acid monomer, (b) a crosslinkable acrylic acid copolymer, (iii) part It contains at least one crosslinkable water-soluble polymer selected from the group consisting of neutralized polyacrylic acid, (iv) a crosslinked carboxyvinyl polymer, and / or (v) a crosslinked cellulose compound. Non-crosslinkable water-soluble polymers include polyvinyl alcohol, polyethylene glycol, polypropylene glycol, starch acrylate, alkyl polyacrylate, polyvinyl pyrrolidone, carboxyalkyl cellulose, hydroxyalkyl cellulose, copolymer of alkyl acrylate and secondary monomers, It contains at least one non-crosslinkable water-soluble polymer selected from the group consisting of gelatin and agar.
Such a water-containing composition has flexibility and tackiness at a temperature of about 45 ° C. or less, has a gel-like shape retaining property in a state of no fluidity, and has antiseptic properties.

  As a water-containing composition comprised in the patch of the present invention, (A) water contains 20 to 95% by weight based on the total content of the water-containing composition, and (B) water-soluble polymer contains water-containing composition. 3 to 40 weight% is contained with respect to the total content of (C), and the structure whose polyhydric alcohol contains 5 to 50 weight% with respect to the total content of a water-containing composition is feasible.

In the water-containing composition provided in the patch, the water content is preferably in the range of about 20 to about 95% by weight, more preferably the water content is in the range of about 25 to about 90% by weight. . The water-containing composition containing water in this range is in a form having optimum flexibility and gel at a temperature of about 45 ° C. or lower.
A water-containing composition having a water content of less than about 20% by weight is in a state where all water-soluble polymers in the water-soluble polymer contained cannot be completely dissolved, and an undissolved powder remains or is dissolved. Even if it does, it will be in the state which does not have fluidity | liquidity at high temperature, or the state where a softness | flexibility falls at normal temperature. Furthermore, there is a tendency that the feeling of use at the time of use such as sticking to the human skin tends to decrease, for example, when the patch containing the water-containing composition is attached to or stuck to the human skin, the user feels a somewhat uncomfortable feeling.
A water-containing composition having a water content of more than about 95% by weight is in a fluid state even at a temperature of about 45 ° C. or lower, making it difficult to obtain a gel-like state without fluidity. There is also a tendency for the adhesiveness to the skin to decrease, and there is a tendency for inconvenience to occur in terms of sticking to the human skin.

In the water-containing composition provided in the patch, the content of the water-soluble polymer is preferably in the range of about 3 to about 40% by weight, and more preferably the content of the water-soluble polymer is about 3 to about 30. It is in the range of wt%. The water-containing composition containing water in this range is in a form having optimum flexibility and gel at a temperature of about 45 ° C. or lower.
A water-containing composition having a water-soluble polymer content of less than about 3% by weight is in a state having fluidity at a temperature of about 20 to 45 ° C. and tends to be inferior in shape retention.
A water-containing composition in which the content of the water-soluble polymer exceeds about 40% by weight makes it impossible to completely dissolve all the water-soluble polymers of the water-soluble polymer contained, and undissolved powder remains. Even if the water-soluble polymer is dissolved, it becomes non-flowable even at high temperatures. Furthermore, when the water-containing composition is used at the time of use such as sticking to the human skin, the flexibility of the water-containing composition decreases at normal temperature, and when the patch containing the water-containing composition is attached to or stuck on the human skin, it feels a little stiff and uncomfortable. There is a tendency for the feeling of use to decrease.

By using the patch comprising the water-containing composition of the present invention, (Effective patch-patch having reduced skin sensitization and excellent antiseptic properties) used by a person with low skin resistance applied to the skin In some cases, it is expected to reduce skin sensitization such as skin irritation of the contacted skin, and a patch exhibiting excellent antiseptic properties can be obtained, and the adhesiveness, shape retention and flexibility required for the patch Thus, it is possible to obtain a patch having the basic properties of a patch such as easy-peeling adhesiveness and peeling residual inhibition property. In particular, when a person with low skin resistance, such as an infant or an elderly person, is used, a reduced skin sensitization is expected, and a patch exhibiting excellent antiseptic properties can be obtained.
In particular, it contains a crosslinkable water-soluble polymer having a gel-like structure that is crosslinked and cross-linked to a network structure, and has a predetermined amount of bound water / dissolved water / free water-containing water content Also in the patch provided with the composition, the patch having the basic performance as the patches (a) to (f) described above, and having reduced skin sensitization and excellent antiseptic properties can be obtained.
Furthermore, according to the type of water-soluble polymer contained, the above-mentioned (effect D: comfortable water retention and flexible shape retention due to the inclusion of the crosslinkable water-soluble polymer, reduced skin sensitization and excellent antiseptic properties ), (Effect E: Comfortable water-retaining flexible adhesive due to inclusion of non-crosslinkable water-soluble polymer), (Effect E: Comfortable water-retaining flexible adhesive due to inclusion of non-crosslinkable water-soluble polymer), etc. An adhesive patch is obtained.

<About the polyhydric alcohol contained in the water-containing composition comprised in the patch>
As the polyhydric alcohol contained in the water-containing composition of the patch of the present invention, a polyhydric alcohol having a property of being dissolved in water or a property compatible with water is desirable.
As polyhydric alcohols, glycerin, propylene glycol, dipropylene glycol, propanediol, butylene glycol, octanediol, polyethylene glycol, polypropylene glycol, sorbite liquid, crotamiton and the like can be used. The sorbit liquid is a viscous liquid in which sorbitol is dissolved in a solvent such as water.
Among these polyhydric alcohols, propylene glycol, butylene glycol, and glycerin are used in combination with preservatives other than parabens such as phenoxyethanol, glyceryl caprylate, and polylysine. It has the effect of preserving antiseptic properties.

  Polyhydric alcohol has a greater viscosity than water, is soluble in water or has a good compatibility with water, and is mixed with water at an arbitrary ratio to form a uniform liquid without separation. In addition, a water-containing composition having desired flexibility, adhesiveness, water retention, and moisture retention can be obtained in accordance with the characteristics of the polyhydric alcohol. Further, in the case of a water-containing composition containing a poorly water-soluble preservative that is hardly soluble in water or other pharmacologically active ingredients that are hardly soluble in water, these preservatives and / or pharmacologically active ingredients are dissolved, and the water-containing composition In this case, the efficacy of these preservatives or pharmacologically active ingredients can be efficiently exhibited.

  That is, the above-mentioned (Effect-Patch: Patch with reduced skin sensitization / excellent antiseptic properties) can be obtained, and (Effect) is provided with a water-containing composition by containing polyhydric alcohol. When the patch is affixed to the human skin, it is adjusted to have an optimal balance performance in all performances such as adhesiveness, flexibility, water retention, shape retention, easy peeling adhesiveness, and residue control after peeling. The effect that can obtain the applied patch is obtained, and further, (effect-a) has the function as a solvent that dissolves a preservative that is particularly insoluble in water, and provides functionalities such as pharmacologically active ingredients. When the component and the preservative are poorly water-soluble, an effect of efficiently exhibiting the efficacy of the preservative or the effect-imparting functional component can be obtained by dissolving and containing these components.

  The optimal content of the polyhydric alcohol contained in the water-containing composition constituted in the patch differs depending on the type of the polyhydric alcohol and the content of the non-crosslinkable water-soluble polymer, for example, 5 to 50% by weight. Desirably, particularly desirable is 5 to 40% by weight. Within this range, the above effect (effect G) is optimally obtained. If the polyhydric alcohol content is less than 5% by weight, the adhesiveness, flexibility and water retention are inferior, and there is a tendency that optimum physical properties cannot be obtained. There is a tendency to be inferior to the property suppression.

In addition, the polyhydric alcohol contained in the water-containing composition constituted in the patch is adhesiveness, flexibility, water retention, shape retention, easy peelability, as described in the above “Effect”, In all performances such as residue control after peeling, it has the function of adjusting to a state having an optimal balance performance, and in particular, glycerin, dipropylene glycol, sorbitol, etc. are functions to increase the moisture retention of the water-containing composition. In addition, propylene glycol, butylene glycol, and the like also have an effect of imparting softness and tackiness of the water-containing composition and an effect as a solvent of a preservative that is hardly soluble in water.
These polyhydric alcohols dissolve additional ingredients such as analgesic / anti-inflammatory ingredients, skin-improving ingredients, refreshing ingredients, preservatives, etc., which are sparingly soluble in water, as a solvent for uniformly containing them in the water-containing composition The function of can also be performed. In the case of a polyhydric alcohol such as glycerin having a high viscosity at room temperature, the viscosity is decreased by increasing the temperature to make it easier to dissolve additional components, or in combination with a lower alcohol such as ethanol or propyl alcohol, the above-mentioned Additional components can be dissolved.

<About the sheet-like holding member>
The sheet-like holding member configured in the patch of the present invention is not particularly limited, as long as the water-containing composition is sufficiently held without being peeled from the sheet-like holding member. Use sheet-like holding members such as fiber aggregates such as nonwoven fabrics or woven fabrics using synthetic fibers and natural fibers, fiber aggregates such as paper, stretchable materials containing stretchable rubber materials, plastic film materials, etc. be able to.
The sheet-like holding member is preferably composed of a porous material having a fine uneven surface capable of passing at least one of air, moisture, and moisture, and the water-containing composition is fine in the sheet-like holding member. An effect of adhering or impregnating and holding the concavo-convex surface inside the concavo-convex surface without being peeled off from the sheet-like holding member is obtained.
In addition, the sheet-like holding member is configured to be stretchable in the planar direction, and the water-containing composition attached and held on the sheet-like holding member is also configured to be stretchable in response to the expansion and contraction of the sheet-like holding member. Configuration is desirable. In the case of a stretchable sheet-like holding member, when a patch in which a water-containing composition is laminated on the sheet-like holding member is applied to a human body, the patch can be stretched and stretched to the human body. In addition, the patch can freely expand and contract in response to the movement of the human body, without causing boundary separation between the sheet-like holding member and the water-containing polymer gel composition, and can be used stably without peeling the patch from the human body. It becomes.

  With this configuration, (Effect No.) The above-described (Effective patch-reduced: reduced skin sensitization / excellence) by the configuration in which the water-containing composition was held by being attached and / or impregnated on the surface of the sheet-like holding member. In particular, it can be applied well to the desired skin of the human body, and the back surface of the sheet-like holding member to which the water-containing composition is not attached is sticky. A patch having non-adhesiveness that does not adhere to human hands or clothing can be obtained.

<About release sheet>
The patch of the present invention may further include a release sheet that covers the water-containing composition adhered and held on the sheet-like holding member and is laminated on the surface of the water-containing composition. In use, the release sheet is peeled off from the patch, and the side of the water-containing composition attached and held on the surface of the sheet-like holding member is attached to the human skin for use. The release sheet is not particularly limited, and a sheet made of a plastic film having releasability that can release the water-containing composition without breakage can be configured from the water-containing composition. For example, a film-like sheet such as polyethylene, polypropylene, polyamide, polyethylene terephthalate can be used.

<About the manufacturing method of the patch provided with the water-containing composition>
A method for producing a patch comprising the water-containing composition of the present invention comprises a sheet-like holding member and a water-containing composition that is attached and / or impregnated and held on the sheet-like holding member, and is applied to human skin. A method for producing a patch, wherein the water-containing composition contains (A) water, and (B) a water-soluble polymer as a functional component that is soluble in the water, and at least, (C) a polyhydric alcohol having a preservative promoting action that is soluble or compatible with the water, and (E) a preservative other than parabens soluble in the water and / or the polyhydric alcohol. The antiseptic other than the parabens contains at least one preservative other than the parabens selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine, and at a temperature of about 45 ° C. or less. ,flexible And which has a gel is a state with no flowability having adhesiveness, has antiseptic properties, formed by attachable configured to human skin.
Such a method for producing a patch comprises the following steps.
(A) A step of mixing and dissolving at least a water-soluble polymer that is soluble in water in water, thereby preparing a water-soluble polymer-containing preconditioning solution that is viscous and fluid.
(C) Preservatives other than parabens and water and / or polyhydric alcohols capable of dissolving the preservatives are mixed to prepare a preservative-containing preparation solution containing the preservatives dissolved therein. Process.
(E) the polyhydric alcohol, the water-soluble polymer-containing preconditioning liquid prepared by (a), and the preservative-containing preconditioning liquid prepared by (c) are mixed, The step of preparing a fluid hydrous polymer composition in which the preservative is dissolved and has a viscosity and fluidity, wherein the fluid hydrous polymer composition is adjusted to a predetermined temperature. It is done.
(F) After the step (e), when the fluidity of the fluid water-containing polymer composition is maintained until it gels, the sheet-like holding member has a predetermined thickness and the fluidity of water content. A step of adhering and / or impregnating the molecular composition, thereby preparing a flowable water-containing polymer composition with a sheet-like holding member held by the sheet-like holding member.
(G) Adjusting the flowable water-containing polymer composition with a sheet-like holding member prepared in the step (f) to a predetermined temperature, whereby the fluid water-containing polymer composition has fluidity. Preparing a water-containing composition that has been gelated into a non-gel state.

In the above-described method for producing a patch, a production method having the following configuration can be desirably implemented. FIG. 1 shows a schematic process explanatory diagram of a production process showing a method for producing a patch comprising this water-containing composition. However, FIG. 1 shows a process in which the water-containing composition further contains an additional component described later.
In (B), the water-soluble polymer includes (B-1) a crosslinkable water-soluble polymer that is crosslinkable in molecular structure, and (B-2) a non-crosslinkable watersoluble polymer that is not crosslinkable in molecular structure. The water-containing composition further includes (D) a crosslinking agent capable of crosslinking the crosslinkable water-soluble polymer in terms of molecular structure, and includes the following steps.
(A-1) A step of mixing and dissolving at least the crosslinkable water-soluble polymer in water, thereby preparing a preliminary solution containing the crosslinkable water-soluble polymer having viscosity and fluidity.
(A-2) at least a step of mixing and dissolving a non-crosslinkable water-soluble polymer in water, thereby preparing a non-crosslinkable water-soluble polymer-containing preconditioning liquid having a viscosity and fluidity;
(B) a step of mixing and dissolving in water at least a crosslinking agent capable of crosslinking the crosslinkable water-soluble polymer in terms of molecular structure, thereby preparing a crosslinking agent-containing preparation solution.
(C) Preservatives other than parabens and water and / or polyhydric alcohols capable of dissolving the preservatives are mixed to prepare a preservative-containing preparation solution containing the preservatives dissolved therein. Process.
(E) Polyhydric alcohol, the crosslinkable water-soluble polymer-containing preconditioning solution prepared by (a-1), and the non-crosslinkable water-soluble polymer-containing preparation prepared by (a-2) The preconditioning liquid, the crosslinker-containing preconditioning liquid prepared in (b), and the preservative-containing preconditioning liquid prepared in (c) are mixed, whereby the preservative is dissolved. And a step of preparing a fluid hydrous polymer composition having viscosity and fluidity.
(F) After the step (e), when the fluidity of the fluid water-containing polymer composition is maintained until it gels, the sheet-like holding member has a predetermined thickness and the fluidity of water content. A step of adhering and / or impregnating the molecular composition, thereby preparing a flowable water-containing polymer composition with a sheet-like holding member held by the sheet-like holding member.
(G) After the step (f), the crosslinkable water-soluble polymer contained in the flowable water-containing polymer composition with a sheet-like holding member is crosslinked into a network structure by a chemical reaction with the crosslinking agent. And a step of preparing a water-containing composition gelled in a gel state having no fluidity.
In the step (d) of FIG. 1, when the additional component or the like cannot be dissolved in water and / or polyhydric alcohol, the additional component or the like is converted into a lower alcohol such as ethanol or propyl alcohol and / or a surface activity. A step of dissolving and mixing in the agent can be performed.

  In the step (a-1), the step (a-2), the step (b), and the step (c), any one of a temperature state lowered to a predetermined temperature, a temperature state raised to a predetermined temperature, or a normal temperature state It is possible to mix in such a state. Further, in the step (e), the mixing can be performed in any of a temperature state lowered to a predetermined temperature, a temperature state raised to a predetermined temperature, or a normal temperature state. Thereby, the fluid water-containing polymer composition having the desired fluidity containing the mixed crosslinkable water-soluble polymer and non-crosslinkable water-soluble polymer is prepared. In the step (g), mixing can be performed in a temperature state adjusted to a predetermined temperature by lowering or raising the temperature, or in a normal temperature state. As a result, the crosslinkable water-soluble polymer contained in the flowable water-containing polymer composition with a sheet-like holding member is cross-linked into a network structure by a chemical reaction with the cross-linking agent, and the gel is formed into a gel state having no fluidity. A patch comprising the hydrated water-containing composition is prepared. In addition, normal temperature means the temperature area | region which does not heat up or cool down specially, for example, is normal room temperature which is a normal working environment, or about 18 to 30 degreeC.

In this production method, the following steps can be desirably performed in the step (e), the step (f), and the step (g).
In the step (e), mixing is performed in a state in which the temperature is raised to a predetermined temperature, and in the step (g), the crosslinkable water-soluble polymer is crosslinked in a temperature range from the temperature rise to room temperature. Can be implemented. In this case, in the step (f), the crosslinking reaction of the crosslinkable water-soluble polymer is promoted by the temperature rise and tends to become a non-flowable gel state in a short time. It is desirable to use a cross-linking agent having such a property that the cross-linking reaction does not proceed while adhering and / or impregnating the molecular composition.

  In this production method, in the step (e), mixing is performed in a state where the temperature is lowered to a predetermined temperature, and in the step (g), the crosslinkable water-soluble polymer is crosslinked in a temperature range from the lowered temperature to room temperature. This manufacturing method can also be implemented. That is, in the step (e), a polyhydric alcohol, a crosslinkable water-soluble polymer-containing preconditioning liquid, a non-crosslinkable water-soluble polymer-containing preconditioning liquid, a crosslinker-containing preconditioning liquid, and a preservative The preliminarily prepared liquid is adjusted so as to have a temperature of room temperature or lower, mixed, and controlled to a low temperature, thereby controlling the progress of the crosslinking reaction, and the fluid hydrous polymer composition in the step (f). Ensuring a long time for maintaining the fluidity until gelling, and adhering and / or impregnating the fluid hydrous polymer composition with a predetermined thickness to the sheet-like holding member In the step (g), the crosslinkable water-soluble polymer contained in the flowable water-containing polymer composition with a sheet-like holding member is used as a crosslinking agent at room temperature or an ambient temperature equal to or higher than room temperature. Cross-linked into a network structure by chemical reaction and flow Preparing gelled water-containing composition into a gel state having no method can also be implemented. In this case, it is desirable to use a cross-linking agent having such a property that a cross-linking reaction occurs in a normal temperature range.

  In the above production method, as the preservative, a configuration not containing a paraben preservative or a configuration in which the paraben content is reduced to 0.05% by weight or less can be implemented.

With this structure, (Effective) In a patch comprising a water-containing composition containing a preservative other than parabens, adhesiveness, flexibility, water retention, shape retention, easy peeling adhesive, remaining after peeling It is possible to produce a patch adjusted to a state having an optimal balance performance in all performances such as property suppression, and in particular, it is possible to produce a patch in which an antiseptic is dissolved in a water-containing composition. Thus, it is possible to produce a patch capable of efficiently exhibiting antiseptic performance even when a smaller amount of preservative is contained.
In other words, it has a shape retaining property that does not have fluidity and can maintain its shape against an external pressure, has a water retaining property that can retain a large amount of sufficient moisture, and, when applied to human skin, it is hard and sticky. A method for producing a patch comprising a water-containing composition having a comfortable water-retaining and flexible shape-retaining property having a comfortable flexibility without a sense of incongruity is obtained. When this patch is used by people with weak skin resistance, it is expected to reduce skin sensitization, such as skin irritation, and it has excellent antiseptic properties. A method for producing a patch comprising a water-containing composition containing molecules is obtained. In particular, when people with low skin resistance, such as infants and the elderly, use it, significant improvement in skin sensitization such as skin irritation can be expected.
Furthermore, (effect i-abd: reduced skin sensitization / excellent antiseptic properties) comprising at least one preservative selected from the group consisting of phenoxyethanol and glyceryl caprylate and polylysine, When a person with low skin resistance uses, it is expected to reduce skin sensitization such as skin irritation in contact with the skin, and a method for producing a patch exhibiting excellent antiseptic properties can be obtained.

In the method for producing a patch comprising the water-containing composition of the present invention, the above-mentioned (B-1) crosslinkable water-soluble polymer, (B-2) non-crosslinkable water-soluble polymer, and the above-mentioned (C) Polyhydric alcohols can be used.
(B-1) Crosslinkable water-soluble polymers include (i) a crosslinkable acrylic acid polymer, (ii) a crosslinkable acrylic acid copolymer, (iii) a crosslinkable acrylic acid polymer, and (iv) a crosslinkable polymer. A carboxyvinyl polymer and (v) a cross-linkable water-soluble polymer of a cross-linkable cellulose compound, and the cross-linkable water-soluble polymer reacts with the cross-linking agent. A crosslinkable water-soluble polymer having a property of being crosslinked into a network structure can be used.
(B-2) Non-crosslinkable water-soluble polymers include polyvinyl alcohol, polyethylene glycol, starch acrylate, alkyl polyacrylate, polyvinyl pyrrolidone, copolymer of alkyl acrylate and secondary monomer, non-crosslinked cellulose, At least one non-crosslinkable water-soluble polymer selected from the group consisting of gelatin and agar can be used.
(C) As the polyhydric alcohol, at least one polyhydric alcohol selected from the group consisting of propylene glycol, dipropylene glycol, butylene glycol, propanediol, glycerin, and sorbite liquid can be used.

With this configuration, the above-described (Effective Patch): a patch exhibiting reduced skin sensitization / excellent antiseptic properties and the above-mentioned (Effect G) are obtained.
Furthermore, the polyhydric alcohol has the above-mentioned “effect effect”, and in particular, glycerin, dipropylene glycol, sorbitol, etc. have a function of enhancing the moisture retention of the water-containing composition, and also propylene glycol, butylene. Glycol and the like also have an effect of imparting softening properties and an effect as a solvent of a preservative that is hardly soluble in water.

  In the method for producing a water-containing composition of the present invention and the method for producing a patch comprising the water-containing composition of the present invention, the water-containing composition further comprises an effect-imparting functional component as a functional component, and / or In addition, the effect-providing functional component contains at least one effect-providing functional component selected from the group consisting of a pharmacologically active component, a skin improving component, and an aroma component, and the additional component is (K-1) An accidental eating prevention component that has a function of feeling bitter when contained in the mouth and suppressing erroneous eating, (K-2) A refreshing feeling imparting component that produces a refreshing feeling, and (K-3) A warm feeling. And (K-4) at least one additional component selected from the group consisting of a pH-adjusting component for adjusting pH, and (d) the above-mentioned effect-imparting functional component, error Anti-food ingredient, refreshing ingredient, warm feeling At least one component selected from the group consisting of a sensation-imparting component and a pH-adjusting component is dissolved or mixed in water and / or a polyhydric alcohol to prepare an effect-imparting functional component / additional component-containing preparation solution. In the step (e), in addition to the respective preparation liquids, the effect-providing functional ingredient / additional ingredient-containing preparation liquid prepared in the step (d) is further mixed, thereby A method for producing a patch comprising the steps of preparing a flowable water-containing polymer composition in which the preservative is dissolved and has a viscosity and fluidity is possible.

Thereby, while the preservative is dissolved, the above-mentioned effect-imparting functional component and the additional component are dissolved in the water-containing composition, or are contained in the water-containing composition in an emulsified state, or These fine particles are contained in a dispersed state.
With this configuration, the water-containing composition or patch containing an effect-imparting functional component or an additional component has an effect that exhibits an effect corresponding to the effect-providing functional component or additional component contained. It is done.

<About the manufacturing method of the patch provided with the water-containing composition containing a preservative>
In the method for producing a patch of the present invention, a water-containing composition containing the following various preservatives can be constituted as a preservative.
In the method for producing a patch of the present invention, the preservative is 0.2 to 1.0% by weight of phenoxyethanol with respect to the total amount, 0.01 to 0.8% by weight of glyceryl caprylate with respect to the total amount, and Containing at least one preservative other than parabens selected from the group consisting of 0.01 to 0.8% by weight of polylysine based on the total amount, and in the step (c), (ca) water and And / or a step of dissolving phenoxyethanol in a polyhydric alcohol, (cb) a step of dissolving glyceryl caprylate in a polyhydric alcohol, and (cd) a step of dissolving polylysine in water. At least one preservative-containing preconditioning solution is prepared, and in the step (e), the preservative has a state dissolved in the fluid hydrous polymer composition.

Moreover, the water-containing composition containing the following various preservatives can be comprised as a preservative.
In (E), the minimum content of preservatives other than the parabens is XY coordinates with the phenoxyethanol content as the X-axis and the content of glyceryl caprylate and / or polylysine as the Y-axis relative to the total amount. Above the line MN connecting the point M where the phenoxyethanol content on the X axis is 0.17 wt% and the point N where the content of glyceryl caprylate and / or polylysine on the Y axis is 0.007 wt% As shown in the region, both preservatives of phenoxyethanol and glyceryl caprylate and / or polylysine are contained. In the step (c), (ca) phenoxyethanol is added to water and / or polyhydric alcohol. A step of dissolving, and (cb) a step of dissolving glyceryl caprylate in a polyhydric alcohol and / or (c- ) A preservative containing preformulation solution step of dissolving the polylysine was prepared in water, in step (e), the preservative has a dissolved state to the flowable water-containing polymeric composition.
In this configuration, a configuration containing phenoxyethanol and glyceryl caprylate, phenoxyethanol and polylysine, or phenoxyethanol, glyceryl caprylate and polylysine can be implemented as the preservative.

That is, phenoxyethanol has a property of being slightly soluble in water and easily soluble in polyhydric alcohol, and glyceryl caprylate has a property of being hardly soluble in water but easily soluble in polyhydric alcohol, Polylysine dissolves easily in water, but has poor solubility in polyhydric alcohols.
When these preservatives having different solubilities are included, in the step (c), water, polyhydric alcohol, or water and many solvents are used as a solvent for dissolving the preservative in accordance with the type of the preservative used. A preserving solution containing a preservative in which the preservative is dissolved is prepared by selectively using a solvent mixed with a monohydric alcohol.
In the step (e), when the non-crosslinkable water-soluble polymer-containing preconditioning liquid, the crosslinking agent-containing preconditioning liquid, and the preservative-containing preconditioning liquid are mixed, water and / or polyvalent Preservative dissolved in alcohol is in the form of fine particles or suspension, resulting in precipitation or dispersion or phase separation, and the preservative is dissolved in the fluid hydrous polymer composition. Prepare preconditioning solution.

  With this configuration, (Effective patch: containing phenoxyethanol and other preservatives / reduced skin sensitization / excellent antiseptic properties) In particular, preserving both phenoxyethanol and glyceryl caprylate and / or polylysine A composition containing a preservative can significantly reduce the content of phenoxyethanol, and can also significantly reduce the content of other preservatives to be used in combination, thereby reducing the total content of the preservatives contained. A method for producing a water-containing polymer gel patch exhibiting sufficient antiseptic properties can also be obtained in a patch comprising In addition to phenoxyethanol, the composition comprising both preservatives of glyceryl caprylate and / or polylysine has the effect of providing superior antiseptic properties compared to the single use of these preservatives at the same preservative concentration. Is obtained.

In the method for producing a patch of the present invention, the water-containing composition contains at least one polyhydric alcohol selected from the group consisting of propylene glycol, butylene glycol and glycerin as the polyhydric alcohol exhibiting antiseptic properties. And at least one preservative selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine as the preservative, and the polyhydric alcohol by containing the polyhydric alcohol and the preservative. Has the effect of promoting the antiseptic properties of the preservative, and in the step (c), a preservative other than parabens and a polyhydric alcohol capable of dissolving the preservative are mixed, whereby the preservative is Desirable configuration, comprising the step of preparing a preservative containing a preservative dissolved and contained Ku can be implemented.
With this configuration, it is possible to efficiently produce a patch exhibiting (Effective Word Patch: Preservative Promoting Effect by Containing Polyhydric Alcohol and Other Preservatives).

  In the method for producing a water-containing composition and the method for producing a patch of the present invention, a structure in which the water-containing composition does not contain parabens or parabens of 0.05% by weight or less that does not affect skin sensitization. It is desirable to implement a structure containing

  In the method for producing a water-containing composition and the method for producing a patch of the present invention, regarding the constituent components such as functional components, preservatives, polyhydric alcohols, and the like, regarding the types, contents and properties of these constituent components These are the same as the matters described for the water-containing composition and the patch.

Examples of the present invention will be described below.
In the Examples, each of the prepared water-containing compositions or patches having the water-containing composition were subjected to a comparative study on antiseptic properties and the like.
[Test method for antiseptic properties]:
(A) One test sample was prepared for each prepared water-containing composition or patch.
(B) Prepare two types of test bacteria: standard bacterial mixed bacteria (E. coli, Pseudomonas aeruginosa, Staphylococcus aureus) and standard fungal mixed bacteria (Koji mold and Candida).
(C) A test bacterial solution is prepared for each of the test bacteria using a sterilized phosphate buffered saline so as to be 1 × 1000000 / mL to 30 × 1000000 / mL, respectively.
(D) Put each water-containing composition or test sample of a patch with a water-containing composition into a sterilization vial and inoculate 0.1 ml of the test bacterial solution. In this case, if the test sample is a water-containing composition, the test sample is the water-containing composition in a petri dish. When the test sample is a patch, a patch in which a water-containing composition is attached to a 20 mm × 20 mm sheet holding member is used as the test sample.
(E) A sterilized vial containing a water-containing composition or a patch containing the water-containing composition inoculated with the above bacterial mixed fungus and fungal mixed bacteria is stored at 25 to 37 ° C. and 95% humidity.
(F) Each water-containing composition or patch test piece inoculated with the test bacterial solution was taken out on the 7th, 14th, 21st, and 28th days, and the viable cell count was measured.
(G) In the measurement result on the 28th day, when the number of inoculated bacteria is 0.01% or less with respect to the mixed bacteria and the number of inoculated fungi is 0.1% or less with respect to the mixed fungi, Judgment was made as good (◯), and the number exceeding these numbers was judged as poor antiseptic (×).

[Testing and measuring method for adhesiveness of patch]:
Measured by the tilted ball tack test method listed in the Pharmaceutical Manufacturing and Sales Guidelines.
Various patch samples are applied to the skin of the human forehead and maintained in a vertical state for 30 minutes to observe whether the patch has fallen off. It was selected as the optimal adhesive patch to have. Then, the optimum adhesive patch was used as a test sample and measured by the tilting ball tack test method to define the basic measurement value by the tilting ball tack test method.
That is, using the prepared patch containing the water-containing composition as a test sample, the test sample is placed on the surface of the water-containing composition on a 30-degree inclined plate so that the water-containing composition of the patch is on the surface side. The adhesion force was measured by rolling iron balls of different sizes and stopping for a certain period of time. And, compared with the basic measurement value by the inclined ball tack test method using the optimal adhesive patch as a test sample, the case where the adhesive force is felt good is judged as good (○), and the adhesive force is felt poor The case was determined as (x).
[Test measurement method for shape retention of patch]:
Inclined at about 45 degrees with the sheet-like holding member side of the patch attached to the plate, and after 3 minutes, observed the flowability of the water-containing composition attached to the surface side, and shaped without flow or deformation The case where it was good was maintained as good (◯), and the case where it flowed and the shape changed was judged as impossible (×).
[Testing and measuring method for flexibility of patch]:
The prepared patch was affixed to the human forehead, and a case where a comfortable and soft feeling was felt was judged as good (◯), and a case where an unpleasant hardness was felt was judged as impossible (×).
[Testing and measuring method for adhesive peel easy adhesion]:
The prepared patch is affixed to the human forehead, and after 3 minutes, it is gradually peeled off from the end of the patch affixed to the forehead, and the skin of the forehead can be easily removed without feeling uncomfortable. The case where it was made was judged as good (◯), and the case where the adhesive force when peeling off was too strong and the skin of the forehead felt uncomfortable and could not be easily peeled off was judged as impossible (×).
[Test measurement method for residual property suppression after peeling (peeling residual suppression)]:
The prepared patch is applied to the human forehead, and after 3 minutes, it is gradually peeled off from the end of the patch applied to the forehead, and it can be removed without any abnormalities. ) And a case where a part of the water-containing composition of the patch was damaged and remained on the human forehead was determined as impossible (×).

A water-containing composition containing water, a water-soluble polymer as a functional component, 1,3-butylene glycol, propylene glycol, glycerin as a polyhydric alcohol, and phenoxyethanol as a preservative, and its water-containing composition Patches provided with articles were prepared, and the antiseptic properties and the like of each of the prepared patches were compared.
FIG. 1 is a schematic process explanatory diagram for explaining a method for producing a patch of one embodiment of the present invention. Consistent with the schematic process diagram of FIG. 1, a water-containing composition and a patch comprising the water-containing composition were prepared by the following steps.

(A-1) While having 10 g of cross-linkable water-soluble polymer such as sodium polyacrylate, partially neutralized polyacrylic acid and cross-linked carboxyvinyl polymer as a functional component mixed in water and having viscosity. A premix solution containing a crosslinkable water-soluble polymer having fluidity is prepared.
(A-2) Mixing and dissolving 6 g of non-crosslinkable water-soluble polymer such as polyvinyl alcohol, non-crosslinked carboxymethyl cellulose, polyalkyl acrylate, etc. as a functional component in water and having viscosity and fluidity A preparation solution containing a non-crosslinkable water-soluble polymer is prepared.
(B) A crosslinking agent-containing preconditioning solution is prepared by mixing and dissolving 0.5 g or less of a crosslinking agent capable of crosslinking a crosslinkable water-soluble polymer in water.
(C) As a preservative, a predetermined amount of phenoxyethanol is mixed and dissolved in propylene glycol to prepare a preservative-containing preparation solution containing the preservative dissolved therein.
(D-1) A preconditioning liquid d1 containing an additional component is prepared by mixing and dissolving acids (0.1 g or less) as pH adjusting components in water.
(D-3) A vitrex drug substance (0.01 g or less, also known as: denatrium benzoate) as an anticorrosive agent is mixed and dissolved in water to prepare an additional component-containing preparation liquid d3.
(E) a mixed polyhydric alcohol of 5 g of 1,3-butylene glycol as a polyhydric alcohol, 5 g of propylene glycol and 8 g of glycerin, a preparatory liquid containing a crosslinkable water-soluble polymer prepared by the above (a-1), Non-crosslinkable water-soluble polymer-containing preconditioning liquid prepared by (a-2), cross-linking agent-containing preconditioning liquid prepared by (b), and preservative-containing preconditioning liquid prepared by (c) The additional component-containing preconditioning liquid d1 prepared by (d-1) and the additional component-containing preconditioning liquid d3 prepared by (d-3) are mixed. In this case, mix at a predetermined temperature. Thus, a fluid hydrous polymer composition having a preservative dissolved therein and having a viscous property and fluidity is prepared.
In this way, a fluid hydrous polymer composition having a fluidity and a viscous property as well as a preservative dissolved therein is prepared.

(F) After the step (e), when maintaining the fluidity until the fluid hydrous polymer composition is gelled, the sheet-like holding member is about 0.5 mm thick and the step (e) The flowable water-containing polymer composition prepared by the above method is adhered and spread and / or impregnated. In this way, a flowable water-containing polymer composition with a sheet-like holding member held by the sheet-like holding member is prepared. The sheet-like holding member is made of a non-woven fabric using a synthetic fiber having a 50 mm vertical width, a rectangular width of about 130 mm, and a thickness of about 1 mm, which can be stretched and contracted in the plane direction, and has air humidity permeability. The sheet-like holding member is used.
(G) The flowable water-containing polymer composition with a sheet-like holding member prepared in the step (f) is adjusted to a predetermined temperature, whereby the flowable water-containing polymer composition with a sheet-like holding member over time. The crosslinkable water-soluble polymer contained in the polymer composition is cross-linked into a network structure by a chemical reaction with the cross-linking agent, and the fluid hydrous polymer composition is gelled into a non-flowable gel state. Prepared hydrous composition.
In addition, in said (e), content of the water contained in a water-containing composition is added and mixed so that the whole quantity of a water-containing composition may be 100g.

Thus, water, a water-soluble polymer having a crosslinkable water-soluble polymer (10 g) and a non-crosslinkable water-soluble polymer (6 g), a polyhydric alcohol (18 g), and a crosslinking agent (0.5 g) And a patch for Samples 1 to 7 containing a water-containing composition containing a pH-adjusting component / anti-corrosion-preventing agent (0.2 g or less in total) and containing various amounts of phenoxyethanol preservative. did. In addition, in the samples 1-7 of a present Example, parabens as antiseptic | preservative are not contained.
In addition, as a comparative example of the preservative, in the step (c), the preservative containing solution p containing preservative was prepared by dissolving the paraben preservative of methylparaben and propylparaben in ethanol without containing phenoxyethanol. A patch containing the preservative-containing preconditioning solution p was prepared (Sample 8).

  It was confirmed that the water-containing composition comprised in each prepared patch had a gel shape having flexibility and tackiness and no fluidity at a temperature of about 45 ° C. or lower. Moreover, the water-containing composition had a transparent state, and it was confirmed that the preservative and other additional components contained were uniformly contained in the water-containing composition. Table 2 shows the measurement results of the physical properties of the patch for each prepared patch. In Table 2, the content of each component is shown in wt% (wt%).

In Table 2, patches (samples 4 to 7) having a phenoxyethanol content of 0.2% by weight or more exhibited good antiseptic properties, and the phenoxyethanol content was less than 0.2% by weight (samples 1 to 3). It turns out that it is inferior to antiseptic in some cases.
On the other hand, as a comparative example (prior art), it was confirmed that when the content of parabens was 0.1% by weight (sample 8), good antiseptic properties were exhibited.

A patch comprising a water-containing composition containing glyceryl caprylate as a preservative was prepared, and the antiseptic properties of each of the prepared patches were compared.
Instead of phenoxyethanol in Example 1, a patch comprising a water-containing composition containing glyceryl caprylate was prepared. In this example, in the step (c), (c) a predetermined amount of glyceryl caprylate as a preservative is mixed and dissolved in propylene glycol to prepare a preservative-containing preparation solution containing the preservative dissolved therein. To do. In this case, the temperature of the glyceryl caprylate having a wax shape is increased at room temperature, and the glyceryl caprylate and propylene glycol in a liquid state are mixed and dissolved. Other steps are the same as those in the first embodiment. Table 3 shows the measurement results of the patch physical properties of each prepared patch. In addition, in the samples 9-14 of a present Example, parabens as antiseptic | preservative are not contained.

  In Table 3, patches (samples 11 to 14) having a glyceryl caprylate content of 0.01% by weight or more exhibited good antiseptic properties, and the glyceryl caprylate content was less than 0.01% by weight (sample 9). In the case of 10), it is understood that the antiseptic property is inferior.

A patch comprising a water-containing composition containing polylysine as a preservative was prepared, and the antiseptic properties of each of the prepared patches were compared.
Instead of phenoxyethanol in Example 1, a patch comprising a water-containing composition containing polylysine was prepared.
In this example, in the step (c), (c) a predetermined amount of polylysine as a preservative is mixed and dissolved in water to prepare a preservative-containing preconditioning solution containing the preservative dissolved therein. Other steps are the same as those in the first embodiment.
Table 4 shows the measurement results of the patch physical properties of each prepared patch. In addition, in the samples 15-20 of a present Example, parabens as antiseptic | preservative are not contained.

  In Table 4, the patch (samples 17 to 20) having a polylysine content of 0.01% by weight or more exhibited good antiseptic properties, and the polylysine content was less than 0.01% by weight (samples 15 and 16). It turns out that it is inferior to antiseptic in some cases.

Prepared a patch with a water-containing composition comprising a water-containing composition containing both phenoxyethanol and other preservatives as preservatives, and compared the antiseptic properties of each of the prepared patches. .
In this example, it was prepared by a method similar to Example 1. However, it replaces with the said (c) process of Example 1, and it changes depending on the kind of antiseptic | preservative, and the said (c) process has the following processes.
(C) A predetermined amount of phenoxyethanol as a preservative is mixed and dissolved in propylene glycol to prepare a phenoxyethanol-containing preconditioning solution containing the preservative dissolved therein.
(C) As a preservative, a predetermined amount of glyceryl caprylate is mixed and dissolved in propylene glycol to prepare a glyceryl caprylate-containing preconditioning solution containing the preservative dissolved therein.
(C) As a preservative, a predetermined amount of polylysine is mixed and dissolved in water to prepare a polylysine-containing preconditioning solution containing the preservative dissolved therein.
(C) A predetermined amount of chlorinated preservative as a preservative is mixed and dissolved in water to prepare a chlorinated preservative-containing preconditioning solution containing the preservative dissolved therein.
Then, the phenoxyethanol-containing preconditioning liquid and other desired preservative-containing preconditioning liquid are mixed to prepare a preservative-containing preconditioning liquid.
Other steps are the same as those in the first embodiment.
Tables 5 and 6 show the measurement results of the physical properties of the patches for each of the prepared patches. In this example, parabens as preservatives are not contained.

In Table 5, sample 30 containing only 0.2% by weight of phenoxyethanol exhibits antiseptic properties, but sample 31 containing only 0.17% by weight of reduced phenoxyethanol does not have antiseptic properties.
Sample 37 containing only 0.01% by weight of glyceryl caprylate exhibits antiseptic properties, while sample 34 containing only 0.007% by weight of glyceryl caprylate has 0.1% by weight of phenoxyethanol and caprylic acid which have no antiseptic properties. Sample 32 containing both 0.003 wt% glyceryl (Q point in FIG. 2) has no preservative properties, but sample 33 contains both 0.1 wt% phenoxyethanol and 0.005 wt% glyceryl caprylate. (S point in FIG. 2) has antiseptic properties.
Sample 35 (0.05 point T in FIG. 2) containing both 0.05% by weight of phenoxyethanol and 0.007% by weight of glyceryl caprylate has antiseptic properties, and 0.15% by weight of phenoxyethanol and glyceryl caprylate. Sample 36 containing both 0.003% by weight (point U in FIG. 2) becomes antiseptic.
That is, in FIG. 2, a patch comprising a composition containing a preservative in a region surrounded by a line XY connecting the X point and the Y point and a line MN connecting the M point and the N point is both It can be seen that the synergistic action of these preservatives makes it possible to reduce the minimum preservative content of each preservative.
In other words, in addition to phenoxyethanol, the composition comprising both the preservatives of glyceryl caprylate provides a better antiseptic property than the use of these preservatives alone at the same preservative concentration. The effect to play is acquired.

In Table 6, sample 40 containing only 0.2% by weight of phenoxyethanol exhibits antiseptic properties, but sample 41 containing only 0.17% by weight of reduced phenoxyethanol does not have antiseptic properties.
Sample 47 containing only 0.01% by weight of polylysine exhibits antiseptic properties, but sample 44 containing only 0.007% by weight of polylysine reduced in weight does not have antiseptic properties. 0.1% by weight of phenoxyethanol and 0.003% by weight of polylysine 2 (point Q in FIG. 2) does not have antiseptic properties, but sample 43 (point S in FIG. 2) containing both 0.1% by weight of phenoxyethanol and 0.005% by weight of polylysine Has antiseptic properties.
Sample 45 containing both 0.05% by weight of phenoxyethanol and 0.007% by weight of polylysine (T point in FIG. 2) became antiseptic, and 0.15% by weight of phenoxyethanol and 0.003% by weight of polylysine. The sample 46 (point U in FIG. 2) including both of the content and the content of% is antiseptic.
That is, in FIG. 2, a patch comprising a composition containing a preservative in a region surrounded by a line XY connecting the X point and the Y point and a line MN connecting the M point and the N point is both It can be seen that the synergistic action of these preservatives makes it possible to reduce the minimum preservative content of each preservative.
In other words, in addition to phenoxyethanol, the composition comprising both preservatives of polylysine and preservatives has the effect of exhibiting superior antiseptic properties compared to the single use of these preservatives at the same preservative concentration. Is obtained.

  This example is a composition containing phenoxyethanol, glyceryl caprylate, and polylysine as preservatives, and contains glycerin, propylene glycol, or 1,3-butylene glycol as a polyhydric alcohol, and a functional component. Examples of a patch comprising a water-containing composition containing a water-soluble polymer as a comparative example, and a comparative example in which the content of a water-soluble polymer was increased in place of a polyhydric alcohol without containing a polyhydric alcohol .

According to the same method as in Example 1, a crosslinking agent is included, and a composition in which the content of glycerin, propylene glycol, and butylene glycol is changed as a polyhydric alcohol, and water-containing compositions containing various preservatives Prepare a patch.
In this embodiment, the step (c) includes (c) a predetermined amount of preservative as a preservative mixed and dissolved in heated glycerin, propylene glycol and / or butylene glycol, and the preservative is dissolved and contained. Prepare a preservative containing antiseptic.
The step (e) includes (e) a polyhydric alcohol such as glycerin, 1,3-butylene glycol and propylene glycol as a polyhydric alcohol, and a crosslinkable water-soluble polymer prepared by the above (a-1). A preparation liquid, a non-crosslinkable water-soluble polymer-containing preparation liquid prepared by (a-2), a crosslinking agent-containing preparation liquid prepared by (b), and the preparation liquid prepared by (c). Preservative-containing preconditioning liquid prepared, additional component-containing preconditioning liquid d1 prepared by (d-1), additional component-containing preconditioning liquid d2 prepared by (d-2), (d-3) The additional component-containing preconditioning liquid d3 prepared in (1) is mixed. In this case, mixing is performed at a predetermined temperature. Thereby, while the antiseptic | preservative is melt | dissolved, the fluid water-containing polymer composition which has fluidity | liquidity while having viscosity is prepared.
Other steps are similar to those of the first embodiment. Tables 7, 8 and 9 show the measurement results of the physical properties of the patches for the prepared patches containing the respective water-containing compositions. In this example, parabens as preservatives are not contained.

As apparent from Table 7, in the sample containing phenoxyethanol 0.2% by weight (samples 70 to 79), the sample containing 18% by weight of polyhydric alcohol such as glycerin, propylene glycol, butylene glycol (samples 70 and 71, 72) has excellent antiseptic properties, and a sample not containing polyhydric alcohol (sample 73) is inferior in antiseptic properties.
A sample containing 5% by weight of glycerin (sample 75) has antiseptic properties, but a sample containing 3% by weight of glycerin (samples 74) is inferior in antiseptic properties.
A sample containing 3% by weight of propylene glycol (sample 77) has antiseptic properties, whereas a sample containing 1% by weight of propylene glycol (sample 76) has poor antiseptic properties.
A sample (sample 79) containing 3% by weight of butylene glycol has antiseptic properties, whereas a sample (sample 78) containing 1% by weight of butylene glycol is inferior in antiseptic properties.
That is, in a composition containing 0.2% by weight of phenoxyethanol, a patch comprising a composition containing about 5% by weight of glycerin and a composition containing about 3% by weight or more of propylene glycol or butylene glycol is used as an antiseptic. It is understood that there is a sex promoting effect.

As apparent from Table 8, in the sample containing glyceryl caprylate 0.01% by weight (samples 80 to 89), the sample containing 18% by weight of polyhydric alcohol such as glycerin, propylene glycol, butylene glycol (sample 80, 81 and 82) have excellent antiseptic properties, and the sample not containing polyhydric alcohol (sample 83) is inferior in antiseptic properties.
A sample containing 5% by weight of glycerin (sample 85) has antiseptic properties, but a sample containing 3% by weight of glycerin (samples 84) is inferior in antiseptic properties.
A sample containing 3% by weight of propylene glycol (sample 87) has antiseptic properties, whereas a sample containing 1% by weight of propylene glycol (sample 86) has poor antiseptic properties.
A sample (sample 89) containing 3% by weight of butylene glycol has antiseptic properties, whereas a sample (sample 88) containing 1% by weight of butylene glycol is inferior in antiseptic properties.
That is, a patch comprising a composition containing 0.01% by weight of glyceryl caprylate, a composition containing 5% by weight of glycerin, and a composition containing about 3% by weight or more of propylene glycol or butylene glycol It is understood that there is a preservative promoting effect.

  In addition, in the step (c) of mixing the preservative, in the preparation of the sample not containing the polyhydric alcohol (sample 83), the preservative containing 10% preservative in which glyceryl caprylate was dissolved in about 10 times the amount of ethanol was contained. Prepare and use preconditioning solution. In addition, in the sample having low polyhydric alcohol content (samples 84 to 87), the preservative was dissolved or compatible with the polyhydric alcohol in a state where the polyhydric alcohol was heated to 50 ° C. or more and became transparent. Prepare preservative containing preservative.

As a comparative example 85, in relation to a sample containing 5% by weight of glycerin of sample 85 and 0.01% by weight of glyceryl caprylate, glyceryl caprylate is previously dissolved in glycerin (c) without passing through the step (e ) In step (a), glyceryl caprylate is mixed with the water-soluble polymer-containing preparatory liquid prepared in step (a) and forcibly mixed to disperse glyceryl caprylate, so that glyceryl caprylate is completely water. A fluid hydrous polymer composition in a state of being dispersed in a fine particle state without being dissolved in the hydrous polymer preconditioning solution containing As a result of measuring the antiseptic properties of the patch thus prepared, the antiseptic properties were (x).
That is, when the preservative is contained in a state completely dissolved in the water-containing composition, the preservative is slightly superior to the state in which the preservative is not completely dissolved in the water-containing composition.

As apparent from Table 9, in the sample containing 0.01% by weight of polylysine (samples 90 to 99), the sample containing 18% by weight of polyhydric alcohol such as glycerin, propylene glycol, butylene glycol (samples 90, 91, 92) has excellent antiseptic properties, and a sample not containing polyhydric alcohol (sample 93) is inferior in antiseptic properties.
A sample containing 5% by weight of glycerin (sample 95) has antiseptic properties, but a sample containing 3% by weight of glycerin (samples 94) is inferior in antiseptic properties.
A sample containing 3% by weight of propylene glycol (sample 97) has antiseptic properties, whereas a sample containing 1% by weight of propylene glycol (sample 96) has poor antiseptic properties.
A sample containing 3% by weight of butylene glycol (sample 99) has antiseptic properties, whereas a sample containing 1% by weight of butylene glycol (sample 98) is inferior in antiseptic properties.
That is, in a composition containing 0.01% by weight of polylysine, a patch containing 5% by weight of glycerin, or a composition containing about 3% by weight or more of propylene glycol or butylene glycol is an antiseptic property. It turns out that there is an effect.

This example is a comparative study of the effect of polyhydric alcohol content on antiseptic properties, and contains a composition containing 0.2% by weight or more of phenoxyethanol, caprylic glyceryl or 0.01% by weight of polylysine. In the composition, the composition containing 5% by weight of glycerin and about 3% by weight or more of propylene glycol or butylene glycol demonstrates that the preservative promotes the antiseptic property. The characteristics were examined for reference.
Therefore, in this example, the sample whose polyhydric alcohol content is less than 5% by weight tends to be inferior to the adhesiveness and flexibility of the patch, and has an inappropriate configuration as a patch. As the patch, a patch comprising a water-containing composition containing 5% by weight of a polyhydric alcohol can be desirably implemented.

Water, a water-soluble polymer as a functional component, and a functional component (such as a pharmacologically active component, a skin-improving component, a fragrance component preservative), a polyhydric alcohol having an accelerating action, a preservative, and an additional component ( Various water-containing compositions containing an accidental eating prevention component, a refreshing sensation imparting component, a warm sensation temperature-sensing component, a pH adjusting component, and the like, and various patches that adhere and hold the water-containing composition on a sheet-like holding member Was prepared.
Consistent with the schematic process diagram shown in FIG. 1, a water-containing polymer gel patch was prepared by the following steps.
(A-1) A crosslinkable water-soluble polymer such as sodium polyacrylate, partially neutralized polyacrylic acid, and crosslinkable carboxyvinyl polymer is mixed and dissolved in water to have viscosity and fluidity. A water-soluble polymer-containing preconditioning solution is prepared.
(A-2) Non-crosslinking property having a viscosity and a fluidity by mixing and dissolving a predetermined amount of a non-crosslinking water-soluble polymer such as polyvinyl alcohol, non-crosslinked carboxymethyl cellulose, polyalkyl acrylate and the like in water. A water-soluble polymer-containing preconditioning solution is prepared.
(B) A crosslinking agent-containing preconditioning solution is prepared by mixing and dissolving 0.5 g or less of a crosslinking agent capable of crosslinking a crosslinkable water-soluble polymer in water.
(C) A predetermined amount of preservative is mixed and dissolved in propylene glycol to prepare a preservative-containing preconditioning solution containing the preservative dissolved therein.
(D-1) A preconditioning liquid d1 containing an additional component is prepared by mixing and dissolving acids (0.1 g or less) as pH adjusting components in water.
(D-2) A predetermined additional component is dissolved in ethanol to prepare an additional component-containing preconditioning liquid d2.
(D-3) A vitrex drug substance (0.01 g or less, also known as: denatrium benzoate) as an anticorrosive agent is mixed and dissolved in water to prepare an additional component-containing preparation liquid d3.
(E) a mixed polyhydric alcohol of glycerin and propylene glycol as a polyhydric alcohol, a cross-linkable water-soluble polymer-containing preparatory solution prepared in (a-1), and (a-2) The prepared non-crosslinkable water-soluble polymer-containing preconditioning solution, the crosslinking agent-containing preconditioning solution prepared in (b), the preservative-containing preconditioning solution prepared in (c), and Additional component-containing preconditioning liquid d1 prepared by d-1), additional component-containing preconditioning liquid d2 prepared by (d-2), and additional component-containing preconditioning liquid prepared by (d-3). Mix with preparation d3. In this case, mixing is performed at a predetermined temperature. Thus, a fluid hydrous polymer composition having a preservative dissolved and having a viscosity and fluidity is prepared.
(F) After the step (e), when the fluidity of the fluid water-containing polymer composition is maintained until gelation, the sheet-like holding member has a thickness of about 0.5 mm and the fluidity of water content. Impregnate spread and / or impregnate sheet composition with molecular composition. Thus, a fluid water-containing polymer composition with a sheet-like holding member held by the sheet-like holding member is prepared. The sheet-like holding member is made of a synthetic fiber having a rectangular shape with a vertical width of 50 mm, a horizontal width of about 130 mm, a thickness of about 1.5 mm, and can be stretched and contracted in the plane direction and has air humidity permeability. A sheet-like holding member made of non-woven fabric is used.
(G) Adjusting the flowable water-containing polymer composition with a sheet-like holding member prepared in the step (f) to a predetermined temperature, thereby allowing the flow with the sheet-like holding member over time. The crosslinkable water-soluble polymer contained in the water-soluble water-containing polymer composition is cross-linked to a network structure by a chemical reaction with the cross-linking agent, and the fluid water-containing polymer composition has fluidity. A patch comprising a water-containing composition gelled in a non-gel state is prepared.
In addition, in said (e), content of the water contained in a water-containing composition is added and mixed so that the whole quantity of a water-containing composition may be 100g.

In this way, water, crosslinkable water-soluble polymer, non-crosslinkable water-soluble polymer, polyhydric alcohol, ethanol, cross-linking agent, pH adjusting component, refreshing component, anti-corrosion agent, etc. A patch having a water-containing composition containing an antiseptic was prepared. The water content was adjusted so that the total amount of the water-containing composition was 100 g.
It was confirmed that the water-containing composition comprised in each prepared patch had a gel shape having flexibility and tackiness and no fluidity at a temperature of about 45 ° C. or lower. Moreover, the water-containing composition had a transparent state, and it was confirmed that the preservative and other additional components contained were uniformly contained in the water-containing composition. Table 10 shows the measurement results of the patch physical properties of each prepared patch. In this example, parabens as preservatives are not contained.

As is apparent from Table 10, any of the patches of Samples 51 to 57 exhibits excellent antiseptic properties.
Samples 51 and 52 are patches in which a water-containing composition is attached to one side of a sheet-like holding member, and are cooling sheets that are used by being attached to a forehead or the like that the human body wants to cool.
Sample 53 is a patch in which a water-containing composition is attached to one side of a sheet-like holding member, and is a cold / warm feeling imparted sheet that is used by being affixed to the skin of a part of the human body that is desired to be warmed.
Samples 54 and 55 are patches in which a water-containing composition is attached to one side of a sheet-like holding member, and are analgesic / anti-inflammatory sheets that are used by being attached to human body inflammation or aching skin.
Samples 56 and 57 are patches in which the water-containing composition is attached to one or both sides of a sheet-like holding member or impregnated and held in a non-woven sheet having fine voids, and is applied to the skin such as the face. It is a sheet for improving skin, moisturizing or improving rough skin, spots, freckles, and the like, and used for the purpose of beautiful skin, for example, a pack sheet for skin improvement or a face mask for skin improvement .
As a face mask for skin improvement, for example, a sheet-like shape having a hole for ear mounting, a hole opened in a part corresponding to a human body mouth, a part corresponding to an eye, and a part corresponding to a nostril and having elasticity A human face covering the forehead, cheeks, and chin except for the mouth, eyes, and nostrils of the human body, with the skin improvement pack sheet impregnated with the water-containing composition in the holding member. Affixed to both ears of the human body like a mask, the skin-improving ingredients contained in the water-containing composition are in contact with the skin of the human body and / or penetrate into the skin through the skin. Thereby, the effect that human body skin is improved corresponding to the contained skin improving component is obtained.

(Comparative example of Example 6)
In Example 5, each patch containing a small amount of the preservative in each of the water-containing compositions and having the same other components was prepared, and the results of measuring the antiseptic properties are shown in Table 11. In addition, in the comparative samples 51-57 of this comparative example, parabens as a preservative are not contained.

  As is clear from Table 11, in the comparative samples of the patches of Comparative Samples 51 to 57, the sample with a reduced content of the preservative tends to be inferior in antiseptic properties.

The present Example compared the physical property about the patch provided with the water-containing composition which changed the content rate of water-soluble polymer and a polyhydric alcohol.
A patch comprising the water-containing composition was prepared by the following steps.
(A-1) A predetermined amount of a crosslinkable water-soluble polymer such as sodium polyacrylate, partially neutralized polyacrylic acid, or a crosslinkable carboxyvinyl polymer is mixed and dissolved in water to have viscosity and fluidity. 1. Prepare a crosslinkable water-soluble polymer-containing preconditioning solution.
(A-2) Non-crosslinking property having a viscosity and a fluidity by mixing and dissolving a predetermined amount of a non-crosslinking water-soluble polymer such as polyvinyl alcohol, non-crosslinked carboxymethyl cellulose, polyalkyl acrylate and the like in water. A water-soluble polymer-containing preconditioning solution is prepared.
(B) A crosslinking agent-containing preconditioning solution is prepared by mixing and dissolving 0.5 g or less of a crosslinking agent capable of crosslinking a crosslinkable water-soluble polymer in water.
(C) As a preservative, a predetermined amount of phenoxyethanol and polylysine are mixed and dissolved in propylene glycol to prepare a preservative-containing preparation solution containing the preservative dissolved therein.
(D-1) A preconditioning liquid d1 containing an additional component is prepared by mixing and dissolving acids (0.1 g or less) as pH adjusting components in water.
(E) A predetermined amount of mixed polyhydric alcohol of 1,3-butylene glycol, propylene glycol and glycerin as a polyhydric alcohol, and a crosslinkable water-soluble polymer-containing preparatory solution prepared according to the above (a-1) A non-crosslinkable water-soluble polymer-containing preconditioning solution prepared by (a-2), a cross-linking agent-containing preconditioning solution prepared by (b), and an antiseptic prepared by (c). The agent-containing preconditioning liquid is mixed with the additional component-containing preconditioning liquid d1 prepared in (d-1). In this case, mixing is performed at a predetermined temperature. Thus, a fluid hydrous polymer composition having a preservative dissolved therein and having a viscosity and fluidity is prepared.
(F) After the step (e), when the fluidity of the fluid water-containing polymer composition is maintained until gelation, the sheet-like holding member has a thickness of about 0.5 mm and the fluidity of water content. Deposit and / or impregnate the molecular composition. Thereby, the fluid water-containing polymer composition with a sheet-like holding member held by the sheet-like holding member is prepared. The sheet-like holding member is made of a non-woven fabric using a synthetic fiber having a vertical width of 50 mm, a horizontal width of about 130 mm, a thickness of about 1 mm, and capable of expanding and contracting in the plane direction and having flexibility in bending and air humidity permeability. Use a sheet-like holding member.
(G) Adjusting the flowable water-containing polymer composition with a sheet-like holding member prepared in the step (f) to a predetermined temperature, thereby allowing the flow with the sheet-like holding member over time. The crosslinkable water-soluble polymer contained in the water-soluble water-containing polymer composition is cross-linked to a network structure by a chemical reaction with the cross-linking agent, and the fluid water-containing polymer composition has fluidity. A formulation with a hydrous composition gelled to a non-gel state is prepared.
In addition, in said (e), content of the water contained in a water-containing composition is added and mixed so that the whole quantity of a water-containing composition may be 100g.

In this way, water, a crosslinkable water-soluble polymer, a non-crosslinkable water-soluble polymer, a polyhydric alcohol, a crosslinking agent, and a pH adjusting component are contained, and phenoxyethanol and polylysine as preservatives are added. A patch comprising the water-containing composition was prepared. The water content was adjusted so that the total amount of the water-containing composition was 100 g.
The implementation results of the prepared patches are shown in Table 12.
In this example, parabens as preservatives are not contained.

From Table 12, the following can be understood.
In the case of a composition having a water content of less than 20% by weight (sample 108), all the water-soluble polymer is not dissolved in the water-containing composition, and a transparent water-containing composition cannot be obtained. In the case where the water content exceeds 95% by weight (sample 100), a gel-like water-containing composition having fluidity at 45 ° C. and no fluidity cannot be obtained, and the shape retention tends to be inferior. .
In the case of a composition having a water-soluble polymer content of 3 to 40% by weight and a polyhydric alcohol content of 5 to 50% by weight (samples 103 and 105), adhesiveness, shape retention, and easy-to-peel adhesiveness , All physical properties such as peeling residual suppression and transparency are good. In the case of a composition (samples 107 and 108) in which the content of the water-soluble polymer exceeds 40% by weight, a transparent water-containing composition is obtained without dissolving all the water-soluble polymers in the water-containing composition. I can't. In the case of a composition having a water-soluble polymer content of less than 3% by weight (samples 100 and 102), it has fluidity at 45 ° C. and tends to be inferior in shape retention.
In the case of a composition (samples 104 and 106) in which the polyhydric alcohol content exceeds 50% by weight, a residue of the water-containing composition remains on the skin when the patch is peeled off after the patch is stuck on the skin. In other words, there is a tendency to be inferior in the peeling-residue suppressing property. In the case of a composition (sample 101) having a polyhydric alcohol content of less than 5% by weight, it tends to be inferior in adhesiveness when the patch is applied to the skin.

In this example, as a preservative, in addition to (E) the preservative other than the parabens, the antifouling property was further compared for the patch provided with the water-containing composition containing (F) the parabens. .
In the step (c) of the method for producing a patch in Example 1, the method has (cp) a step of dissolving parabens in water and / or polyhydric alcohol, and (c-a) water or polyhydric alcohol Containing a preservative, a step of dissolving phenoxyethanol in (b), a step of (cb) dissolving glyceryl caprylate in a polyhydric alcohol, or (cd) a step of dissolving polylysine in water It has the process of preparing a preconditioning liquid, and prepares the preservative containing preservative containing dissolved preservative. Other steps are the same as those in the first embodiment. As the parabens, a mixture of equal amounts of both methylparaben and propylparaben was used. Table 13 shows the measurement results of the physical properties of the patches for each of the prepared patches.

From Table 13, the following can be understood.
A sample containing 0.05% by weight of parabens and containing no preservatives other than parabens (sample 117), a sample containing 0.05% by weight of phenoxyethanol (sample 111), and 0.003% by weight of glyceryl caprylate The contained sample (sample 113) and the sample containing polylysine 0.003% by weight (sample 115) are inferior in antiseptic properties.
On the other hand, when 0.05% by weight of parabens and 0.1% by weight of phenoxyethanol are contained (sample 112), when 0.05% by weight of parabens and 0.005% by weight of glyceryl caprylate are contained When (Sample 114) contains 0.05% by weight of parabens and 0.005% by weight of polylysine (Sample 116), it has excellent antiseptic properties in any case.
That is, when the minimum content of preservatives other than the above-mentioned parabens is reduced by using in combination with a preservative other than the above-mentioned parabens in addition to 0.05% by weight or less of the parabens based on the total amount Has excellent antiseptic properties.

Polyhydric alcohol with antiseptic promoting action, preservatives other than parabens, ibuprofen piconol as a functional ingredient that adds efficacy, other additional ingredients, and water mixed in a creamy hydrate A composition was prepared. That is, (a) a functional component is mixed in water, thereby preparing a functional component-containing preparatory solution, (c) a preservative other than parabens, water capable of dissolving the preservative, and / Or mixed with a polyhydric alcohol, thereby preparing a preservative-containing preparation solution containing dissolved preservative, (e) the polyhydric alcohol and the function prepared by (a) The preservative containing the active ingredient and the preservative containing the preservative prepared in (c) were mixed, thereby preparing a water-containing composition in which the functional ingredient and the preservative were dissolved. . Table 14 shows the measurement results such as antiseptic properties of the prepared water-containing compositions.
In this example, parabens as preservatives are not contained. Moreover, the mixed polyhydric alcohol of the equivalence ratio of 1: 1 is used for the content rate of the propylene glycol as a polyhydric alcohol, and a butylene glycol.
The water-containing composition of this example has a cream state, and is applied to the face of a human body to be used as a skin drug for improving the skin condition of the face.

Table 14 shows the following.
A sample containing 0.1% by weight of phenoxyethanol (sample 120) and a sample containing 0.005% by weight of glyceryl caprylate (sample 122) have poor antiseptic properties. On the other hand, the sample (sample 121) containing 0.3% by weight of phenoxyethanol and the sample (sample 123) containing 0.01% by weight of glyceryl caprylate are excellent in antiseptic properties. That is, a water-containing composition containing less than 0.3% by weight of phenoxyethanol is inferior in antiseptic properties, and a water-containing composition containing 0.3% by weight or more of phenoxyethanol is excellent in antiseptic properties.
Sample 124 (Q point in FIG. 2) containing both 0.1% by weight of phenoxyethanol and 0.003% by weight of glyceryl caprylate does not have antiseptic properties, but 0.1% by weight of phenoxyethanol and 0.005% of glyceryl caprylate The sample 125 (both S points in FIG. 2) including both of the weight% has antiseptic properties. That is, in FIG. 2, a patch comprising a composition containing a preservative in a region surrounded by a line XY connecting the X point and the Y point and a line MN connecting the M point and the N point, It can be seen that the synergistic action of both preservatives makes it possible to reduce the minimum preservative content of each preservative and the total content of both preservatives. In other words, in addition to phenoxyethanol, the composition comprising both the preservatives of glyceryl caprylate provides a better antiseptic property than the use of these preservatives alone at the same preservative concentration. The effect to play is acquired.

In addition, the sample (sample 121) containing 0.3% by weight of phenoxyethanol and 10% by weight of polyhydric alcohol exhibits excellent antiseptic properties, whereas it contains 0.3% by weight of phenoxyethanol. A sample (sample 126) containing 4% by weight of glycerin as a polyhydric alcohol is inferior in antiseptic properties.
The sample containing 0.01% by weight of glyceryl caprylate and 10% by weight of polyhydric alcohol (sample 123) exhibits excellent antiseptic properties, but in contrast, 0.005% by weight of glyceryl caprylate A sample (sample 127) containing propylene glycol and polybutylene glycol as polyhydric alcohols and 2% by weight is inferior in antiseptic properties.
A sample (sample 125) containing both phenoxyethanol and glyceryl caprylate and containing 10% by weight of polyhydric alcohol exhibits excellent antiseptic properties, whereas phenoxyethanol and glyceryl caprylate A sample (sample 128) containing both preservatives and containing 4% by weight of glycerin as a polyhydric alcohol is inferior in antiseptic properties.

  That is, in a water-containing composition containing phenoxyethanol and / or glyceryl caprylate, a composition containing 5% by weight or more of glycerin as a polyhydric alcohol, or 3% by weight or more of propylene glycol and / or butylene glycol. It is understood that a composition containing a monohydric alcohol exhibits excellent antiseptic properties, and these polyhydric alcohols exhibit an antiseptic promoting effect of phenoxyethanol and / or glyceryl caprylate.

(Example 10 and comparative example)
The present examples and comparative examples include a water-containing composition containing a water-soluble polymer such as a crosslinked water-soluble polymer or a non-cross-linked water-soluble polymer as a functional component, and a water-containing composition not containing a water-soluble polymer. About the patch provided with the article, the antiseptic properties of the obtained patches were compared.
Through the following steps, a water-containing composition and a patch provided with the water-containing composition were prepared.
(A-1) A predetermined amount of a crosslinkable water-soluble polymer such as sodium polyacrylate, partially neutralized polyacrylic acid, or a crosslinkable carboxyvinyl polymer is mixed and dissolved in water to have viscosity and fluidity. 1. Prepare a crosslinkable water-soluble polymer-containing preconditioning solution.
(A-2) Contains a non-crosslinkable water-soluble polymer having a viscosity and a fluidity by mixing and dissolving a predetermined amount of a non-crosslinkable water-soluble polymer such as polyvinyl alcohol and non-crosslinked carboxymethyl cellulose in water. Prepare preconditioning solution.
(B) A crosslinking agent-containing preconditioning solution is prepared by mixing and dissolving 0.5 g or less of a crosslinking agent capable of crosslinking a crosslinkable water-soluble polymer in water.
(C) As a preservative, a predetermined amount of phenoxyethanol and polylysine are mixed and dissolved in propylene glycol to prepare a preservative-containing preparation solution containing the preservative dissolved therein.
(D-1) A preconditioning liquid d1 containing an additional component is prepared by mixing and dissolving acids (0.1 g or less) as pH adjusting components in water.
(E) A predetermined amount of mixed polyhydric alcohol of 1,3-butylene glycol, propylene glycol and glycerin as a polyhydric alcohol, and a crosslinkable water-soluble polymer-containing preparatory solution prepared according to the above (a-1) A non-crosslinkable water-soluble polymer-containing preconditioning solution prepared by (a-2), a cross-linking agent-containing preconditioning solution prepared by (b), and an antiseptic prepared by (c). The agent-containing preconditioning liquid is mixed with the additional component-containing preconditioning liquid d1 prepared in (d-1). In this case, mixing is performed at a predetermined temperature. Thus, a fluid hydrous polymer composition having a preservative dissolved therein and having a viscosity and fluidity is prepared.
(F) After the step (e), when the fluidity of the fluid water-containing polymer composition is maintained until gelation, the sheet-like holding member has a thickness of about 0.5 mm and the fluidity of water content. Deposit and / or impregnate the molecular composition. Thereby, the fluid water-containing polymer composition with a sheet-like holding member held by the sheet-like holding member is prepared. The sheet-like holding member is made of a non-woven fabric using a synthetic fiber having a vertical width of 50 mm, a horizontal width of about 130 mm, a thickness of about 1 mm, and capable of expanding and contracting in the plane direction and having flexibility in bending and air humidity permeability. Use a sheet-like holding member.
(G) Adjusting the flowable water-containing polymer composition with a sheet-like holding member prepared in the step (f) to a predetermined temperature, thereby allowing the flow with the sheet-like holding member over time. The crosslinkable water-soluble polymer contained in the water-soluble water-containing polymer composition is cross-linked to a network structure by a chemical reaction with the cross-linking agent, and the fluid water-containing polymer composition has fluidity. A patch comprising a water-containing composition gelled in a non-gel state is prepared.
In addition, in said (e), content of the water contained in a water-containing composition is added and mixed so that the whole quantity of a water-containing composition may be 100g.

In this way, water, a crosslinkable water-soluble polymer, a non-crosslinkable water-soluble polymer, a polyhydric alcohol, a crosslinking agent, and a pH adjusting component are contained, and phenoxyethanol and polylysine as preservatives are added. A patch comprising the water-containing composition was prepared. The water content was adjusted so that the total amount of the water-containing composition was 100 g.
In addition, about the sample which does not contain the crosslinkable water-soluble polymer of said (a-1) process and / or the non-crosslinkable water-soluble polymer of (a-2) process, these (a-1) The process or (a-2) process is not provided.
The results are shown in Table 15 for each prepared patch. In addition, in a present Example and a comparative example, parabens as antiseptic | preservative are not contained.
In the case of samples (samples 131, 133, 135, and 137) that do not contain a crosslinkable water-soluble polymer, the water-containing composition having fluidity without being gelled in the step (g) is a sheet-like holding member. A patch that was impregnated and retained was prepared.

From Table 15, the following can be understood.
A patch (sample 130) comprising a water-containing composition containing 0.2% by weight of phenoxyethanol and 3% by weight of a water-soluble polymer, 0.01% by weight of polylysine and 3% by weight of a water-soluble polymer A patch (sample 132) provided with a water-containing composition containing water, and a water-containing composition containing 0.1% by weight of phenoxyethanol and 0.005% by weight of polylysine and 3% by weight of a water-soluble polymer The patch (sample 134) exhibits excellent antiseptic properties, but in contrast, the patch (sample 131) provided with a water-containing composition containing 0.2% by weight of phenoxyethanol and not containing a water-soluble polymer. ), A patch (sample 133) comprising a water-containing composition containing 0.01% by weight of polylysine and not containing a water-soluble polymer, phenoxyethanol .1 wt% and water with containing 0.005% polylysine polymer 3 wt% patch having a water-containing composition containing no (Sample 135) is inferior in antiseptic. That is, in a composition containing the same content ratio of phenoxyethanol or polylysine preservative, the patch (sample 130, 132, 134, 136, 137) provided with a water-containing composition containing 3% by weight of a water-soluble polymer is On the other hand, the patch (samples 131, 133, 135) provided with a water-containing composition that does not contain a water-soluble polymer tends to be inferior in antiseptic properties.

  In addition, a present Example compares the antisepticity by the presence or absence of water-soluble polymer containing, and the sample which is not suitable for using as a patch is also included.

  According to the present invention, in a water-containing composition containing functional components such as water and a water-soluble polymer, the water-containing composition that can exhibit sufficient antiseptic properties and has reduced skin sensitization, and the water-containing composition thereof Patches, cosmetics, and pharmaceutical products for skins provided with a product can be obtained.

Claims (23)

A water-containing composition containing (A) water and (B) a functional component that is soluble in the water,
(C) a polyhydric alcohol having a preservative promoting action that is soluble or compatible with the water;
(E) a preservative other than parabens soluble in the water and / or polyhydric alcohol;
Containing
The preservative other than the parabens is at least one preservative other than the parabens selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine,
Containing
A water-containing composition characterized by having antiseptic properties.   2. The water-containing composition according to claim 1, wherein the polyhydric alcohol exhibiting antiseptic properties contains at least one polyhydric alcohol selected from the group consisting of propylene glycol, butylene glycol, and glycerin. object. The polyhydric alcohol having an antiseptic property promoting action is at least based on the total amount,
3% by weight or more of propylene glycol,
3% by weight or more of butylene glycol, and
The water-containing composition according to claim 1, comprising at least one polyhydric alcohol selected from the group consisting of 5% by weight or more of glycerin. Preservatives other than the parabens, at least with respect to the total amount,
0.2-1.0 wt% phenoxyethanol,
0.01-0.8 wt% glyceryl caprylate, and
0.01-0.8 wt% polylysine,
The water-containing composition according to any one of claims 1 to 3, comprising at least one preservative other than parabens selected from the group consisting of: Preservatives other than the parabens are at least:
Phenoxyethanol,
Glyceryl caprylate and / or polylysine;
The water-containing composition according to any one of claims 1 to 3, wherein both of the preservatives are contained. Preservatives other than the parabens are at least:
Phenoxyethanol,
Glyceryl caprylate and
Containing both preservatives,
The minimum content of preservatives other than the parabens is based on the total amount,
In the XY coordinates where the phenoxyethanol content is the X axis and the glyceryl caprylate content is the Y axis, the phenoxyethanol content in the X axis is 0.17% by weight and the glyceryl caprylate content in the Y axis is 0.007. The preservatives of both phenoxyethanol and glyceryl caprylate are contained so as to be in the region above the straight line connecting the point of weight%,
The water-containing composition according to claim 5. Preservatives other than the parabens are at least:
Phenoxyethanol,
With polylysine,
Containing both preservatives,
The minimum content of preservatives other than the parabens is based on the total amount,
In the XY coordinates where the phenoxyethanol content is the X axis and the polylysine content is the Y axis, the phenoxyethanol content on the X axis is 0.17% by weight and the polylysine content on the Y axis is 0.007% by weight. The preservatives of both phenoxyethanol and polylysine are contained so as to be in the region above the straight line connecting the points,
The water-containing composition according to claim 5. Contains no parabens preservatives,
The water-containing composition according to any one of claims 1 to 7, wherein In addition to preservatives other than the parabens,
Furthermore, (F) containing 0.05% by weight or less of parabens with respect to the total amount,
The water-containing composition according to any one of claims 1 to 7, wherein The functional component is a water-soluble polymer that is soluble in water,
The water-soluble hydrate is dissolved in the water,
The water, the water-soluble polymer, the polyhydric alcohol, and the preservatives other than the parabens are dissolved or compatible with each other.
The water-containing composition according to any one of claims 1 to 9, wherein The water-soluble polymer is
(A) a cross-linkable water-soluble polymer that can be cross-linked to a network structure in terms of molecular structure,
In the vicinity of room temperature of about 18 to about 30 ° C., the crosslinkable water-soluble polymer has a non-flowable gel shape that is cross-linked in a state dissolved in water in the presence of a cross-linking agent.
(B) a crosslinkable water-soluble polymer that can be cross-linked to a network structure in terms of molecular structure,
In the vicinity of room temperature of about 18 to about 30 ° C., the crosslinkable water-soluble polymer has a fluid viscous state in which it is not cross-linked when dissolved in water in the absence of a cross-linking agent.
(C) contains a non-crosslinkable water-soluble polymer that does not crosslink in molecular structure,
In the vicinity of room temperature of about 18 to about 30 ° C., the non-crosslinkable water-soluble polymer has a fluid viscosity that is not cross-linked when dissolved in water.
Or
(D) having both a water-soluble polymer having both a crosslinkable water-soluble polymer that can be cross-linked to a network structure in molecular structure and a non-cross-linkable water-soluble polymer that does not cross-link molecularly;
In the vicinity of room temperature of about 18 to about 30 ° C., the crosslinkable water-soluble polymer has a non-flowable gel shape that is cross-linked in the state of being dissolved in the water in the presence of a cross-linking agent. The non-crosslinkable water-soluble polymer has a fluid viscosity that is not crosslinked in water.
The water-containing composition according to claim 10. The water-soluble polymer as the functional component contains at least one of a crosslinkable water-soluble polymer and a non-crosslinkable water-soluble polymer,
The water-soluble polymer is contained in a state dissolved in the water,
The crosslinkable water-soluble polymer is
(I) a crosslinkable acrylic acid polymer obtained by polymerizing at least one acrylic acid monomer of acrylic acid, methacrylic acid, and a monovalent metal salt thereof;
(Ii) (a) acrylic acid, methacrylic acid, and at least one acrylic monomer based on these monovalent metal salts; and (b) alkyl acrylate and alkyl methacrylate. A cross-linked acrylic acid copolymer obtained by copolymerizing at least one alkyl acrylate monomer;
(Iii) a partially neutralized polyacrylic acid cross-linked acrylic acid polymer obtained by partially neutralizing polyacrylic acid;
(Iv) a crosslinked carboxyvinyl polymer;
And / or
(V) sodium carboxyalkyl cellulose and / or hydroxyalkyl cellulose sodium cross-linked cellulose compound,
The non-crosslinkable water-soluble polymer is
(Vi) polyvinyl alcohol, polyethylene glycol, polypropylene glycol, starch acrylate, alkyl polyacrylate, carboxyalkyl cellulose, hydroxyalkyl cellulose, polyvinyl pyrrolidone, copolymer of alkyl acrylate and secondary monomer, gelatin, and agar, Is at least one non-crosslinkable water-soluble polymer selected from the group consisting of:
The water-containing composition according to claim 10. The functional component is the water-soluble polymer according to claim 11 or 12 and / or an effect-imparting functional component,
The water-containing composition according to any one of claims 1 to 12, wherein the effect-imparting functional component is at least one selected from the group consisting of a pharmacologically active component, a skin improving component, and an aromatic component. Composition. In addition, it contains additional ingredients
The additional component is
(K-1) An accidental eating prevention component having a function of feeling bitter when contained in the mouth and suppressing erroneous eating,
(K-2) a refreshing feeling imparting component that provides a refreshing feeling,
(K-3) a warm sensation imparting component that produces a warm sensation, and
(K-4) pH adjusting component for adjusting pH,
The water-containing composition according to claim 1, comprising at least one additional component selected from the group consisting of:   A patch, a cosmetic product, or a pharmaceutical preparation for skin, comprising at least the water-containing composition according to any one of claims 1 to 14. A water-containing composition according to any one of claims 1 to 14, and a sheet-like holding member,
The water-containing composition is attached and / or impregnated and held on the sheet-like holding member,
The functional component contained in the water-containing composition contains a water-soluble polymer that is soluble in water,
A patch which is formed to be stickable on human skin and has antiseptic properties. The functional component has a water-soluble polymer, both a cross-linkable water-soluble polymer that can be cross-linked to a network structure in terms of molecular structure and a non-cross-linkable water-soluble polymer that does not cross-link in terms of molecular structure,
The crosslinkable water-soluble polymer has fluidity until it is cross-linked by a chemical reaction in the presence of a cross-linking agent in a state dissolved in water, and after being cross-linked by a chemical reaction with the cross-linking agent. Has a gel-like state that is not fluid,
The non-crosslinkable water-soluble polymer has a fluid viscous state that is not crosslinked in a state dissolved in water,
The crosslinkable water-soluble polymer is
(I) a crosslinkable acrylic acid polymer obtained by polymerizing at least one acrylic acid monomer of acrylic acid, methacrylic acid, and a monovalent metal salt thereof;
(Ii) (a) acrylic acid, methacrylic acid, and at least one acrylic monomer based on these monovalent metal salts; and (b) alkyl acrylate and alkyl methacrylate. A cross-linked acrylic acid copolymer obtained by copolymerizing at least one alkyl acrylate monomer;
(Iii) a partially neutralized polyacrylic acid cross-linked acrylic acid polymer obtained by partially neutralizing polyacrylic acid;
(Iv) a cross-linked carboxyvinyl polymer, and / or
(V) sodium carboxyalkylcellulose and / or a crosslinked cellulose compound of hydroxyalkylcellulose sodium,
The non-crosslinkable water-soluble polymer is
(Vi) polyvinyl alcohol, polyethylene glycol, polypropylene glycol, starch acrylate, polyalkyl acrylate, polyvinyl pyrrolidone, carboxyalkyl cellulose, hydroxyalkyl cellulose, copolymer of alkyl acrylate and secondary monomer, gelatin, and agar At least one non-crosslinkable water-soluble polymer selected from the group consisting of
The water-containing composition has flexibility and tackiness at a temperature of about 45 ° C. or less, has a gel-like shape retaining property in a non-flowable state, and has antiseptic properties. The patch described in 1. In the water-containing composition,
The water contains 20 to 95 wt% with respect to the total content of the water-containing composition,
The water-soluble polymer contains 3 to 40% by weight with respect to the total content of the water-containing composition,
The patch according to claim 16 or 17, wherein the polyhydric alcohol contains 5 to 50% by weight based on the total content of the water-containing composition. A method for producing a water-containing composition having antiseptic properties according to any one of claims 1 to 14,
The water-containing composition is
(A) water and
(B) a functional component soluble in the water;
(C) a polyhydric alcohol having a preservative promoting action that is soluble or compatible with the water;
(E) a preservative other than parabens soluble in the water and / or polyhydric alcohol;
Containing
The preservative other than the parabens is at least one preservative other than the parabens selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine,
Containing
(A) a step of mixing and dissolving at least a functional component that is soluble in water in water, thereby preparing a functional component-containing preparation solution;
(C) Preservatives other than parabens and water and / or polyhydric alcohols capable of dissolving the preservatives are mixed to prepare a preservative-containing preparation solution containing the preservatives dissolved therein. Process
(E) the polyhydric alcohol, the functional ingredient-containing preconditioning liquid prepared in (a), and the preservative-containing preconditioning liquid prepared in (c) above are mixed, Preparing a water-containing composition in which the functional ingredient and the preservative are dissolved,
A method for producing a water-containing composition, comprising: A method for producing the patch according to any one of claims 16 to 18, comprising:
A method for producing a patch comprising a sheet-like holding member and a water-containing composition attached and / or impregnated and held on the sheet-like holding member, which can be applied to human skin,
The water-containing composition contains (A) water and (B) a water-soluble polymer as a functional component that is soluble in the water, and at least,
(C) a polyhydric alcohol having a preservative promoting action that is soluble or compatible with the water;
(E) a preservative other than parabens soluble in the water and / or polyhydric alcohol;
Containing
The preservative other than the parabens is at least one preservative other than the parabens selected from the group consisting of phenoxyethanol, glyceryl caprylate, and polylysine,
Containing
At a temperature of about 45 ° C. or less, it has a gel shape that is soft and sticky and has no fluidity, has antiseptic properties, and can be applied to human skin,
(A) a step of mixing and dissolving at least a water-soluble polymer that is soluble in water in water, thereby preparing a water-soluble polymer-containing preconditioning solution that is viscous and fluid;
(C) Preservatives other than parabens and water and / or polyhydric alcohols capable of dissolving the preservatives are mixed to prepare a preservative-containing preparation solution containing the preservatives dissolved therein. Process
(E) the polyhydric alcohol, the water-soluble polymer-containing preconditioning liquid prepared by (a), and the preservative-containing preconditioning liquid prepared by (c) are mixed, A step of preparing a flowable water-containing polymer composition in which the preservative is dissolved and has viscosity and fluidity;
Here, the fluid hydrous polymer composition is adjusted to a predetermined temperature.
(F) After the step (e),
When the fluidity of the fluid water-containing polymer composition is maintained until it gels, the sheet-like holding member adheres and / or contains the fluidity of the water-containing polymer composition at a predetermined thickness. Invading,
Thereby, a step of preparing a flowable hydrous high molecular weight composition with a sheet-like holding member held by the sheet-like holding member,
(G) Adjusting the flowable water-containing polymer composition with a sheet-like holding member prepared in the step (f) to a predetermined temperature, whereby the fluid water-containing polymer composition has fluidity. A step of preparing a patch comprising a water-containing composition gelled in a non-gel state,
A method for producing a patch, comprising: In (B), the water-soluble polymer is
(B-1) a crosslinkable water-soluble polymer that is crosslinkable in molecular structure;
(B-2) contains a non-crosslinkable water-soluble polymer that cannot be crosslinked in terms of molecular structure,
The water-containing composition further includes
(D) a crosslinking agent capable of crosslinking the crosslinkable water-soluble polymer in terms of molecular structure;
(A-1) A step of mixing and dissolving at least a crosslinkable water-soluble polymer in water, thereby preparing a prepolymer solution containing a crosslinkable water-soluble polymer having viscosity and fluidity;
(A-2) at least a step of mixing and dissolving a non-crosslinkable water-soluble polymer in water, thereby preparing a non-crosslinkable water-soluble polymer-containing preconditioning liquid having a viscosity and fluidity;
(B) a step of mixing and dissolving in water at least a crosslinking agent capable of crosslinking the crosslinkable water-soluble polymer in terms of molecular structure, thereby preparing a crosslinking agent-containing preconditioning solution;
(C) Preservatives other than parabens and water and / or polyhydric alcohols capable of dissolving the preservatives are mixed to prepare a preservative-containing preparation solution containing the preservatives dissolved therein. Process
(E) Polyhydric alcohol, the crosslinkable water-soluble polymer-containing preconditioning solution prepared by (a-1), and the non-crosslinkable water-soluble polymer-containing preparation prepared by (a-2) The preconditioning liquid, the crosslinker-containing preconditioning liquid prepared in (b), and the preservative-containing preconditioning liquid prepared in (c) are mixed, whereby the preservative is dissolved. A step of preparing a fluid hydrous polymer composition having viscosity and fluidity, wherein the fluid hydrous polymer composition is adjusted to a predetermined temperature.
(F) After the step (e),
The fluid hydrous polymer composition adheres and / or impregnates the sheet-like holding member at a predetermined thickness when the fluidity of the fluid hydrous polymer composition is maintained until it gels. A step of preparing a flowable hydrous high molecular weight composition with a sheet-like holding member held by the sheet-like holding member,
(G) The flowable water-containing polymer composition with a sheet-like holding member prepared in the step (f) is adjusted to a predetermined temperature, and thereby contained in the fluid water-containing polymer composition with a sheet-like holding member. A water-containing composition in which the crosslinkable water-soluble polymer is cross-linked to a network structure by a chemical reaction with the cross-linking agent, and the fluid hydrous polymer composition is gelled into a gel state having no fluidity A step of preparing a patch with an article
The method for producing a patch according to claim 20, comprising: The (B-1) crosslinkable water-soluble polymer is
(I) a crosslinkable acrylic acid polymer obtained by polymerizing at least one acrylic acid monomer of acrylic acid, methacrylic acid, and a monovalent metal salt thereof;
(Ii) (a) acrylic acid, methacrylic acid, and at least one acrylic monomer based on these monovalent metal salts; and (b) alkyl acrylate and alkyl methacrylate. A cross-linked acrylic acid copolymer obtained by copolymerizing at least one alkyl acrylate monomer;
(Iii) a partially neutralized polyacrylic acid cross-linked acrylic acid polymer obtained by partially neutralizing polyacrylic acid;
(Iv) a cross-linked carboxyvinyl polymer, and / or
(V) sodium carboxyalkylcellulose and / or hydroxyalkylcellulose sodium is a cross-linked cellulose compound,
The (B-2) non-crosslinkable water-soluble polymer comprises polyvinyl alcohol, polyethylene glycol, starch acrylate, alkyl polyacrylate, carboxyalkyl cellulose, hydroxyalkyl cellulose, polyvinyl pyrrolidone, alkyl acrylate and a secondary monomer. At least one non-crosslinkable water-soluble polymer selected from the group consisting of polymerized polymer, gelatin, and agar;
The (C) polyhydric alcohol is at least one polyhydric alcohol selected from the group consisting of propylene glycol, dipropylene glycol, butylene glycol, propanediol, glycerin, and sorbite liquid.
The method for producing a patch according to any one of claims 20 and 21, wherein: The water-containing composition further contains an effect-imparting functional component as a functional component, and / or an additional component,
The effect-providing functional component is at least one effect-providing functional component selected from the group consisting of a pharmacologically active component, a skin improving component, and an aromatic component,
The additional component is
(K-1) An accidental eating prevention component having a function of feeling bitter when contained in the mouth and suppressing erroneous eating,
(K-2) a refreshing feeling imparting component that provides a refreshing feeling,
(K-3) a warm sensation imparting component that produces a warm sensation, and
(K-4) pH adjusting component for adjusting pH,
At least one additional ingredient selected from the group consisting of:
further,
(D) at least one additional component selected from the group consisting of the above-mentioned effect-imparting functional component, the accidental eating prevention component, the refreshing sensation imparting component, the warm sensation temperature-sensing component and the pH adjusting component Or dissolving or mixing in a polyhydric alcohol to prepare a prescription liquid containing an effect-imparting functional component / additional component,
In the step (e), in addition to the respective preparation liquids, the effect-providing functional ingredient / additional ingredient-containing preparation liquid prepared in the step (d) is further mixed, whereby the preservative is added. A step of preparing a flowable water-containing polymer composition that is dissolved and has viscosity and fluidity;
The method for producing a water-containing composition according to claim 19 or the method for producing a patch according to any one of claims 20 to 22, characterized by comprising:

Images