JP2017122073A - Aqueous skin cosmetic - Google Patents
Aqueous skin cosmetic Download PDFInfo
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- JP2017122073A JP2017122073A JP2016002828A JP2016002828A JP2017122073A JP 2017122073 A JP2017122073 A JP 2017122073A JP 2016002828 A JP2016002828 A JP 2016002828A JP 2016002828 A JP2016002828 A JP 2016002828A JP 2017122073 A JP2017122073 A JP 2017122073A
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- 239000002537 cosmetic Substances 0.000 title claims abstract description 81
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- -1 fatty acid ester Chemical class 0.000 claims abstract description 24
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 20
- 229920001214 Polysorbate 60 Polymers 0.000 claims abstract description 12
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 12
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
- 239000004359 castor oil Substances 0.000 claims abstract description 8
- 235000019438 castor oil Nutrition 0.000 claims abstract description 8
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 8
- 150000005215 alkyl ethers Chemical class 0.000 claims abstract description 6
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 6
- 150000002009 diols Chemical class 0.000 claims abstract description 6
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims abstract description 6
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 6
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims abstract description 6
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000000194 fatty acid Substances 0.000 claims abstract description 6
- 229930195729 fatty acid Natural products 0.000 claims abstract description 6
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims abstract description 6
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims abstract description 6
- 229960002216 methylparaben Drugs 0.000 claims abstract description 6
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 6
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 claims abstract description 5
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims abstract description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims abstract description 5
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims abstract description 5
- 229940058015 1,3-butylene glycol Drugs 0.000 claims abstract description 4
- 235000019437 butane-1,3-diol Nutrition 0.000 claims abstract description 4
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000003921 oil Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 229920003169 water-soluble polymer Polymers 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 abstract description 23
- 206010040880 Skin irritation Diseases 0.000 abstract description 3
- 230000036556 skin irritation Effects 0.000 abstract description 3
- 231100000475 skin irritation Toxicity 0.000 abstract description 3
- 239000003755 preservative agent Substances 0.000 description 16
- 230000035909 sensory irritation Effects 0.000 description 14
- 230000000116 mitigating effect Effects 0.000 description 12
- 208000003251 Pruritus Diseases 0.000 description 11
- 230000007803 itching Effects 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 10
- 230000002335 preservative effect Effects 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 238000000926 separation method Methods 0.000 description 9
- 230000035807 sensation Effects 0.000 description 6
- 238000005259 measurement Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000004793 Polystyrene Substances 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 230000001771 impaired effect Effects 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 230000037307 sensitive skin Effects 0.000 description 3
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 231100000245 skin permeability Toxicity 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000002834 transmittance Methods 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- OXJGJKIURHREKH-UHFFFAOYSA-O CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C Chemical compound CC(=C)C(=O)OCCP(=O)=C(O)C[N+](C)(C)C OXJGJKIURHREKH-UHFFFAOYSA-O 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000047703 Nonion Species 0.000 description 1
- 239000004288 Sodium dehydroacetate Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- NCHJGQKLPRTMAO-XWVZOOPGSA-N [(2R)-2-[(2R,3R,4S)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NCHJGQKLPRTMAO-XWVZOOPGSA-N 0.000 description 1
- IJCWFDPJFXGQBN-RYNSOKOISA-N [(2R)-2-[(2R,3R,4S)-4-hydroxy-3-octadecanoyloxyoxolan-2-yl]-2-octadecanoyloxyethyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCCCCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCCCCCCCCCCCC IJCWFDPJFXGQBN-RYNSOKOISA-N 0.000 description 1
- NVANJYGRGNEULT-BDZGGURLSA-N [(3s,4r,5r)-4-hexadecanoyloxy-5-[(1r)-1-hexadecanoyloxy-2-hydroxyethyl]oxolan-3-yl] hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](OC(=O)CCCCCCCCCCCCCCC)[C@H]1OC(=O)CCCCCCCCCCCCCCC NVANJYGRGNEULT-BDZGGURLSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000002511 behenyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 229940067596 butylparaben Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 235000019259 sodium dehydroacetate Nutrition 0.000 description 1
- 229940079839 sodium dehydroacetate Drugs 0.000 description 1
- DSOWAKKSGYUMTF-GZOLSCHFSA-M sodium;(1e)-1-(6-methyl-2,4-dioxopyran-3-ylidene)ethanolate Chemical compound [Na+].C\C([O-])=C1/C(=O)OC(C)=CC1=O DSOWAKKSGYUMTF-GZOLSCHFSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 239000001589 sorbitan tristearate Substances 0.000 description 1
- 235000011078 sorbitan tristearate Nutrition 0.000 description 1
- 229960004129 sorbitan tristearate Drugs 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- 150000003626 triacylglycerols Chemical class 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、水系皮膚化粧料に関する。 The present invention relates to a water-based skin cosmetic.
従来、化粧品、医薬品、食品等の組成物には、防腐性を付与し、長期間にわたる品質を確保するため、各種の防腐剤が配合されている。代表的な防腐剤として、メチルパラベン、エチルパラベン等のパラベン類、フェノキシエタノールが広く用いられている。しかし、これらの防腐剤を配合した化粧料等は、肌が敏感なヒトにおいて、ヒリヒリ、チクチクといった感覚刺激感を誘発し、時には発赤、炎症が生じることがある。 Conventionally, various preservatives are blended in compositions such as cosmetics, pharmaceuticals, and foods in order to impart antiseptic properties and ensure quality over a long period of time. As typical preservatives, parabens such as methylparaben and ethylparaben, and phenoxyethanol are widely used. However, cosmetics and the like containing these preservatives induce a sense of irritation such as tingling and tingling in humans with sensitive skin, sometimes causing redness and inflammation.
このような防腐剤配合皮膚化粧料における刺激を緩和する手段として、（１）防腐剤に加えてメタクリロイルオキシエチルホスホリルコリン重合体や共重合体を配合する手段（特許文献１、非特許文献１）、（２）防腐剤に加えて１，３−プロパンジオールを併用した防腐技術（特許文献２）が報告されている。 As means for alleviating irritation in such a preservative-containing skin cosmetic, (1) means for blending a methacryloyloxyethyl phosphorylcholine polymer or copolymer in addition to the preservative (Patent Document 1, Non-Patent Document 1), (2) An antiseptic technique (Patent Document 2) using 1,3-propanediol in combination with an antiseptic has been reported.
しかしながら、特許文献１記載の手段では、特殊なポリマーを配合する必要があり、また刺激緩和作用が十分でなかった。さらに、特許文献２記載の手段でも、刺激緩和作用は十分でなかった。
したがって、本発明の課題は、防腐剤の有する防腐性を低下させることなく、かつ感覚的な刺激感が十分に緩和され、また、塗布後の肌にみずみずしさが得られた水系皮膚化粧料を提供することにある。
However, in the means described in Patent Document 1, it is necessary to blend a special polymer, and the stimulus mitigating action is not sufficient. Furthermore, even the means described in Patent Document 2 is not sufficient for the stimulus relaxation action.
Accordingly, an object of the present invention is to provide an aqueous skin cosmetic that does not reduce the antiseptic properties of the preservative, that is sufficiently relaxed in sensory irritation, and that provides freshness to the skin after application. It is to provide.
そこで本発明者は、化粧料組成物中においては防腐剤の防腐性を妨げず、皮膚に適用した際に防腐剤の皮膚への浸透を抑制して感覚刺激性を緩和できる化粧料を開発すべく種々検討した結果、防腐剤に加えて、特定平均分子量のポリエチレングリコール、特定のポリオキシエチレン系ノニオン界面活性剤及び特定のジオール類を、特定の比率で配合することにより、防腐剤による防腐性と感覚刺激性緩和作用との両立を達成でき、また、塗布後の肌にみずみずしさが得られることを見出し、本発明を完成した。 Therefore, the present inventor has developed a cosmetic that can mitigate sensory irritation by preventing penetration of the preservative into the skin when applied to the skin without impeding the antiseptic properties of the preservative in the cosmetic composition. As a result of various investigations, as a result of adding a specific average molecular weight polyethylene glycol, a specific polyoxyethylene nonionic surfactant and a specific diol in a specific ratio in addition to the preservative, antiseptic properties by the preservative The present invention has been completed by discovering that it is possible to achieve both a sensation-stimulating and mitigating action and to obtain freshness on the skin after application.
すなわち、本発明は、次の成分（Ａ）、（Ｂ）、（Ｃ）、（Ｄ）及び（Ｅ）：
（Ａ）（Ａ１）メチルパラベン及び／若しくはエチルパラベン、又は（Ａ２）フェノキシエタノール、
（Ｂ）数平均分子量３０００〜３００００のポリエチレングリコール、
（Ｃ）ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油及びポリオキシエチレンアルキルエーテルから選ばれる１種以上のノニオン界面活性剤、
（Ｄ）ジプロピレングリコール、１，３−ブチレングリコール及び１，３−プロパンジオールから選ばれる１種以上のジオール、
（Ｅ）水
を含有し、成分（Ｂ）と（Ｃ）の合計に対する成分（Ａ）の質量比〔（Ａ）／［（Ｂ）＋（Ｃ）］〕が、成分（Ａ）が（Ａ１）の場合は０．１以上２．５以下であり、成分（Ａ）が（Ａ２）の場合は０．５以上５以下である水系皮膚化粧料を提供するものである。
That is, the present invention includes the following components (A), (B), (C), (D) and (E):
(A) (A1) methylparaben and / or ethylparaben, or (A2) phenoxyethanol,
(B) a polyethylene glycol having a number average molecular weight of 3000 to 30000,
(C) one or more nonionic surfactants selected from polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ethers,
(D) one or more diols selected from dipropylene glycol, 1,3-butylene glycol and 1,3-propanediol,
(E) The mass ratio [(A) / [(B) + (C)]] of the component (A) with respect to the sum of the components (B) and (C) containing water and the component (A) is (A1 ) Is 0.1 or more and 2.5 or less, and when the component (A) is (A2), it provides an aqueous skin cosmetic that is 0.5 or more and 5 or less.
本発明の水系皮膚化粧料は、成分（Ａ）による水系皮膚化粧料の防腐性が十分に発揮され、かつ皮膚に適用した際には成分（Ａ）の皮膚浸透性が抑制されるため、感覚刺激性が十分に緩和されるため、肌が敏感なヒトに対しても継続して使用できる。また、塗布後の肌にみずみずしさを得ることができる。
なお、防腐性とは、防腐力の強さと防腐力の維持のことを示し、防腐力の強さとは、菌数を一定以下のレベルまで減少させる早さを示し、防腐力の維持とは、菌数を減少させた後、菌数を減少した状態を維持することを示す。
また、感覚刺激性とは、化粧料を肌に塗布した後に感じる、例えば、痛みやむずむずした感覚などを示す。
また、水系皮膚化粧料とは、水を５０質量％以上含有する化粧料を示す。
The water-based skin cosmetic of the present invention exhibits the preservability of the water-based skin cosmetic by the component (A) sufficiently, and the skin permeability of the component (A) is suppressed when applied to the skin. Since irritation is sufficiently relaxed, it can be used continuously even for humans with sensitive skin. Moreover, freshness can be obtained in the skin after application.
The antiseptic property indicates the strength of the antiseptic power and the maintenance of the antiseptic power, and the strength of the antiseptic power indicates the speed at which the number of bacteria is reduced to a certain level or less. It shows that after reducing the number of bacteria, the state in which the number of bacteria is reduced is maintained.
Moreover, sensory irritation | stimulation shows the feeling etc. which are felt after apply | coating cosmetics to skin, for example, a pain and itching.
The aqueous skin cosmetic refers to a cosmetic containing 50% by mass or more of water.
本発明に用いられる成分（Ａ）は、防腐剤であり、（Ａ１）メチルパラベン（パラオキシ安息香酸メチル）及び／若しくはエチルパラベン（パラオキシ安息香酸エチル）、又は（Ａ２）フェノキシエタノールである。これらの成分は、化粧品等の防腐剤として広く用いられている。本発明の水系皮膚化粧料は、メチルパラベンとエチルパラベンを単独で含有してもよいし、共に含有してもよい。 Component (A) used in the present invention is a preservative, and is (A1) methyl paraben (methyl paraoxybenzoate) and / or ethyl paraben (ethyl paraoxybenzoate), or (A2) phenoxyethanol. These components are widely used as preservatives for cosmetics and the like. The aqueous skin cosmetic of the present invention may contain methyl paraben and ethyl paraben alone or together.
成分（Ａ）のうち、成分（Ａ１）は、防腐力の強さ、感覚刺激性の緩和効果を向上させる観点から、水系皮膚化粧料中に０．０５〜０．５０質量％含有するのが好ましく、０．０８〜０．４２質量％含有するのがより好ましく、０．１２〜０．３５質量％含有するのがさらに好ましい。また、成分（Ａ２）は、同様の観点から、水系皮膚化粧料中に０．１〜１．０質量％含有するのが好ましく、０．２〜０．９質量％含有するのがより好ましく、０．３〜０．８質量％含有するのがさらに好ましい。 Among the components (A), the component (A1) is contained in the aqueous skin cosmetic in an amount of 0.05 to 0.50% by mass from the viewpoint of improving the antiseptic strength and the sensory irritation mitigating effect. Preferably, it is contained in an amount of 0.08 to 0.42 mass%, more preferably 0.12 to 0.35 mass%. Moreover, it is preferable to contain 0.1-1.0 mass% in a water-based skin cosmetic from a similar viewpoint, and, as for a component (A2), it is more preferable to contain 0.2-0.9 mass%, It is more preferable to contain 0.3-0.8 mass%.
また、本発明の水系皮膚化粧料は、本発明の効果を損しない範囲で、成分（Ａ）を除く他の防腐剤を含有することができ、その含有量は、水系皮膚化粧料中に１．０質量％以下が好ましく、０．５質量％以下がより好ましく、０．１質量％以下がさらに好ましく、含有しないことがよりさらに好ましい。ここで、他の防腐剤としては、プロピルパラベン、ブチルパラベン、安息香酸又はその塩、デヒドロ酢酸ナトリウム等が挙げられる。 Moreover, the water-based skin cosmetic of the present invention can contain other preservatives excluding the component (A) as long as the effects of the present invention are not impaired, and the content thereof is 1 in the water-based skin cosmetic. 0.0 mass% or less is preferable, 0.5 mass% or less is more preferable, 0.1 mass% or less is more preferable, and it is still more preferable not to contain. Here, examples of other preservatives include propylparaben, butylparaben, benzoic acid or a salt thereof, and sodium dehydroacetate.
本発明に用いられる成分（Ｂ）は、数平均分子量３０００〜３００００のポリエチレングリコールである。数平均分子量が３０００〜３００００のポリエチレングリコールを用いることによって、感覚刺激性の緩和効果が高くなり、かつ水系皮膚化粧料の白濁、分離を抑制し、塗布した際の糸曳きを抑制することができる。ポリエチレングリコールの好ましい数平均分子量は、感覚刺激性の緩和効果を向上させ、水系皮膚化粧料の白濁、分離を抑制する観点から、３０００〜３００００であり、より好ましくは８０００〜２７０００であり、さらに好ましくは１５０００〜２５０００である。なお、数平均分子量は、後述の実施例記載の方法で測定される。 Component (B) used in the present invention is polyethylene glycol having a number average molecular weight of 3000 to 30000. By using polyethylene glycol having a number average molecular weight of 3000 to 30000, the sensory irritation mitigating effect is enhanced, and the white turbidity and separation of the water-based skin cosmetic can be suppressed, and stringing when applied can be suppressed. . The preferred number average molecular weight of polyethylene glycol is 3000 to 30000, more preferably 8000 to 27000, and more preferably from the viewpoint of improving the sensory irritation mitigating effect and suppressing the white turbidity and separation of the aqueous skin cosmetic. Is 15000-25000. The number average molecular weight is measured by the method described in the examples below.
成分（Ｂ）は、防腐力を維持し、感覚刺激性の緩和効果、塗布後の肌のみずみずしさを向上させる観点から、水系皮膚化粧料中に０．０５〜１質量％含有するのが好ましく、０．０６〜０．９質量％含有するのがより好ましく、０．０７〜０．８質量％含有するのがさらに好ましい。また、この範囲の含有量にすることで、成分（Ｂ）に起因する塗布後の肌の皮膜感を低減することができる。 Component (B) is preferably contained in the aqueous skin cosmetic in an amount of 0.05 to 1% by mass from the viewpoint of maintaining antiseptic power, improving the sensory irritation, and improving the freshness of the skin after application. 0.06 to 0.9 mass% is more preferable, and 0.07 to 0.8 mass% is more preferable. Moreover, the film | membrane feeling of the skin after the application resulting from a component (B) can be reduced by setting it as content of this range.
本発明に用いられる成分（Ｃ）は、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油及びポリオキシエチレンアルキルエーテルから選ばれる１種以上のノニオン界面活性剤である。成分（Ｃ）は、成分（Ｂ）と共に成分（Ａ）と相互作用して成分（Ａ）の皮膚への浸透を抑制すると考えられる。本発明の水系皮膚化粧料は、皮膚へ塗布し、なじませると、水系皮膚化粧料から水が揮発し、皮膚上で成分（Ａ）、（Ｂ）及び（Ｃ）の濃度が高くなると推測される。そして、成分（Ｂ）に成分（Ａ）及び（Ｃ）が吸着され、見かけ上、成分（Ａ）、（Ｂ）及び（Ｃ）が一体となり、大きな会合体を形成するので、皮膚への浸透を抑制するものと考えられる。 Component (C) used in the present invention is at least one nonionic surfactant selected from polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ether. The component (C) is considered to interact with the component (A) together with the component (B) to suppress the penetration of the component (A) into the skin. When the water-based skin cosmetic of the present invention is applied to the skin and applied, water is volatilized from the water-based skin cosmetic, and the concentrations of the components (A), (B) and (C) are estimated to increase on the skin. The Then, the components (A) and (C) are adsorbed on the component (B), and the components (A), (B) and (C) are apparently integrated to form a large aggregate, so that it penetrates into the skin. It is thought that it suppresses.
ポリオキシエチレンソルビタン脂肪酸エステルを構成するポリオキシエチレン（以下、ＰＯＥという）の平均付加モル数は、水系皮膚化粧料の白濁や分離を抑制する観点から、６〜３０が好ましく、１０〜２５がより好ましく、１５〜２２がさらに好ましい。ＰＯＥソルビタン脂肪酸エステルを構成する脂肪族アシル鎖は、化粧料の白濁や分離を抑制する観点から、炭素数１２〜２４が好ましく、炭素数１６〜２２であることがより好ましい。具体的には、ＰＯＥソルビタンモノパルミチン酸エステル、ＰＯＥソルビタンモノステアリン酸エステル、ＰＯＥソルビタンモノイソステアリン酸エステル、ＰＯＥモノオレイン酸エステル、ＰＯＥソルビタントリパルミチン酸エステル、ＰＯＥソルビタントリステアリン酸エステル、ＰＯＥソルビタントリオレイン酸エステル等が挙げられる。これらの１種又は２種以上を含有することができる。 The average number of added moles of polyoxyethylene (hereinafter referred to as POE) constituting the polyoxyethylene sorbitan fatty acid ester is preferably 6-30, more preferably 10-25, from the viewpoint of suppressing white turbidity and separation of the aqueous skin cosmetic. Preferably, 15 to 22 is more preferable. The aliphatic acyl chain constituting the POE sorbitan fatty acid ester preferably has 12 to 24 carbon atoms, and more preferably 16 to 22 carbon atoms, from the viewpoint of suppressing white turbidity and separation of the cosmetic. Specifically, POE sorbitan monopalmitate, POE sorbitan monostearate, POE sorbitan monoisostearate, POE monooleate, POE sorbitan tripalmitate, POE sorbitan tristearate, POE sorbitan triolein Acid ester etc. are mentioned. These 1 type (s) or 2 or more types can be contained.
ＰＯＥ硬化ヒマシ油のＰＯＥの平均付加モル数は、水系皮膚化粧料の白濁や分離を抑制する観点から、５〜９０が好ましく、２０〜８０がより好ましく、３０〜７０がさらに好ましい。ＰＯＥ硬化ヒマシ油の具体例としては、ＰＯＥ（４０）硬化ヒマシ油、ＰＯＥ（６０）硬化ヒマシ油等が挙げられる。これらの１種又は２種以上を含有することができる。 The average added mole number of POE in the POE hydrogenated castor oil is preferably 5 to 90, more preferably 20 to 80, and still more preferably 30 to 70, from the viewpoint of suppressing white turbidity and separation of the aqueous skin cosmetic. Specific examples of POE hydrogenated castor oil include POE (40) hydrogenated castor oil, POE (60) hydrogenated castor oil, and the like. These 1 type (s) or 2 or more types can be contained.
ＰＯＥアルキルエーテルのＰＯＥの平均付加モル数は、水系皮膚化粧料の白濁や分離を抑制する観点から、１０〜３５が好ましく、１２〜３０がより好ましく、１５〜２５がさらに好ましい。ＰＯＥアルキルエーテルを構成するアルキル鎖は、アルキル又はアルケニル基のどちらでもよく、炭素数としては、水系皮膚化粧料の白濁や分離を抑制する観点から、１２〜２６が好ましく、１４〜２４がより好ましく、１８〜２２がさらに好ましい。当該アルキル鎖の具体例としては、オレイル、ステアリル、ベヘニル、２−オクチルドデシル、２−ヘキシルデシル、２−ヘプチルウンデシル等が挙げられ、オレイル、２−オクチルドデシル、２−ヘキシルデシル、２−ヘプチルウンデシルが好ましく、オレイル、２−オクチルドデシルがより好ましい。これらの１種又は２種以上を含有することができる。 The average added mole number of POE of the POE alkyl ether is preferably 10 to 35, more preferably 12 to 30, and further preferably 15 to 25, from the viewpoint of suppressing the white turbidity and separation of the aqueous skin cosmetic. The alkyl chain constituting the POE alkyl ether may be either an alkyl or alkenyl group, and the carbon number is preferably 12 to 26, more preferably 14 to 24, from the viewpoint of suppressing white turbidity and separation of the aqueous skin cosmetic. 18-22 are more preferable. Specific examples of the alkyl chain include oleyl, stearyl, behenyl, 2-octyldodecyl, 2-hexyldecyl, 2-heptylundecyl, etc., and oleyl, 2-octyldecyl, 2-hexyldecyl, 2-heptyl Undecyl is preferable, and oleyl and 2-octyldodecyl are more preferable. These 1 type (s) or 2 or more types can be contained.
成分（Ｃ）は、感覚刺激性の緩和効果を向上させ、防腐力を維持させる観点から、水系皮膚化粧料中に０．０５〜１質量％含有するのが好ましく、０．０６〜０．９質量％含有するのがより好ましく、０．０７〜０．８質量％含有するのがさらに好ましい。
また、本発明の水系皮膚化粧料は、成分（Ｃ）以外のノニオン界面活性剤を含有することができ、水系皮膚化粧料の白濁や分離を抑制する観点から、水系皮膚化粧料中における全ノニオン界面活性剤中の成分（Ｃ）の含有割合は、６０％以上が好ましく、７０％以上がより好ましく、９０％以上がさらに好ましく、１００％であることがよりさらに好ましい。
Component (C) is preferably contained in an aqueous skin cosmetic composition in an amount of 0.05 to 1% by mass from the viewpoint of improving the sensory irritation mitigating effect and maintaining antiseptic power, and 0.06 to 0.9%. More preferably, it is contained in an amount of 0.07 to 0.8% by mass.
Further, the aqueous skin cosmetic of the present invention can contain a nonionic surfactant other than the component (C), and from the viewpoint of suppressing white turbidity and separation of the aqueous skin cosmetic, all nonions in the aqueous skin cosmetic are included. The content of component (C) in the surfactant is preferably 60% or more, more preferably 70% or more, still more preferably 90% or more, and even more preferably 100%.
成分（Ｂ）と成分（Ｃ）は共に、成分（Ａ）と相互作用して成分（Ａ）の皮膚への浸透を抑制することによって成分（Ａ）による感覚刺激性を緩和する効果を奏すると考えられる。したがって、成分（Ｂ）と（Ｃ）の合計に対する成分（Ａ）の質量比〔（Ａ）／［（Ｂ）＋（Ｃ）］〕は、感覚刺激性の緩和効果を向上させ、防腐力の強さを向上させる観点から、成分（Ａ）が（Ａ１）の場合は０．１以上２．５以下であり、成分（Ａ）が（Ａ２）の場合は０．５以上５以下である。成分（Ａ）が（Ａ１）の場合、〔（Ａ）／［（Ｂ）＋（Ｃ）］〕は、防腐力の強さを向上させる観点から、０．７以上が好ましく、０．９以上がより好ましく、感覚刺激性の緩和効果を向上させる観点から、２．２以下が好ましく、１．８以下がより好ましい。また成分（Ａ）が（Ａ２）の場合、〔（Ａ）／［（Ｂ）＋（Ｃ）］〕は、防腐力の強さを向上させる観点から、０．７以上が好ましく、１．６以上がより好ましく、感覚刺激性の緩和効果を向上させる観点から、４．５以下が好ましく、４．０以下がより好ましい。 Both the component (B) and the component (C) interact with the component (A) to suppress the penetration of the component (A) into the skin, thereby reducing the sensory irritation caused by the component (A). Conceivable. Therefore, the mass ratio [(A) / [(B) + (C)]] of the component (A) with respect to the sum of the components (B) and (C) improves the sensory irritation mitigation effect and increases the antiseptic power. From the viewpoint of improving strength, the ratio is from 0.1 to 2.5 when the component (A) is (A1), and from 0.5 to 5 when the component (A) is (A2). When the component (A) is (A1), [(A) / [(B) + (C)]] is preferably 0.7 or more and 0.9 or more from the viewpoint of improving the strength of the antiseptic power. Is more preferable, and from the viewpoint of improving the sensory irritation mitigating effect, 2.2 or less is preferable, and 1.8 or less is more preferable. When component (A) is (A2), [(A) / [(B) + (C)]] is preferably 0.7 or more from the viewpoint of improving the strength of the antiseptic, and 1.6 The above is more preferable, and 4.5 or less is preferable and 4.0 or less is more preferable from the viewpoint of improving the sensory stimulus relaxation effect.
また、成分（Ｂ）と成分（Ｃ）の質量比、すなわち成分（Ｃ）に対する成分（Ｂ）の質量比[（Ｂ）／（Ｃ）]は、感覚刺激性の緩和効果を向上させる観点から、０．１〜５が好ましく、０．２〜４がより好ましく、０．３〜２．５がさらに好ましい。 Further, the mass ratio of the component (B) and the component (C), that is, the mass ratio of the component (B) to the component (C) [(B) / (C)] is from the viewpoint of improving the sensory irritation mitigating effect. 0.1 to 5 is preferable, 0.2 to 4 is more preferable, and 0.3 to 2.5 is more preferable.
本発明に用いられる成分（Ｄ）は、ジプロピレングリコール、１，３−ブチレングリコール及び１，３−プロパンジオールから選ばれる１種以上のジオールである。成分（Ｄ）の配合により、成分（Ａ）の防腐力の強さが向上し、成分（Ａ）を水系皮膚化粧料中に析出せずに安定に存在させることが可能となる。成分（Ａ）が析出せずに安定に存在するのは、成分（Ｄ）が溶剤として働くためと考えられる。これらのジオールは１種又は２種以上用いることができる。
成分（Ｄ）は、防腐力の強さ及び水系皮膚化粧料の白濁や分離を抑制する観点から、水系皮膚化粧料中に１〜１５質量％含有するのが好ましく、２〜１２質量％含有するのがより好ましく、３〜１０質量％含有するのがさらに好ましい。
Component (D) used in the present invention is one or more diols selected from dipropylene glycol, 1,3-butylene glycol and 1,3-propanediol. By blending the component (D), the strength of the antiseptic power of the component (A) is improved, and the component (A) can be stably present without being precipitated in the aqueous skin cosmetic. The reason why the component (A) exists stably without precipitating is considered that the component (D) works as a solvent. These diols can be used alone or in combination of two or more.
Component (D) is preferably contained in the aqueous skin cosmetic in an amount of 1 to 15% by mass, and from 2 to 12% by mass from the viewpoint of suppressing the antiseptic power and suppressing the cloudiness and separation of the aqueous skin cosmetic. Is more preferable, and it is more preferable to contain 3-10 mass%.
本発明に用いられる成分（Ｅ）は、水である。本発明は、水系皮膚化粧料であり、水を大量に、すなわち、５０質量％以上含有するものである。成分（Ｅ）の水系皮膚化粧料中の含有量は、塗布後の肌のみずみずしさを向上させる観点から、５０質量％以上９７質量％以下が好ましく、６０質量％以上９５質量％以下がより好ましく、７０質量％以上９０質量％以下がさらに好ましい。 The component (E) used in the present invention is water. The present invention is a water-based skin cosmetic and contains a large amount of water, that is, 50% by mass or more. The content of the component (E) in the aqueous skin cosmetic is preferably 50% by mass to 97% by mass, more preferably 60% by mass to 95% by mass, from the viewpoint of improving the freshness of the skin after application. 70 mass% or more and 90 mass% or less are more preferable.
また、本発明の水系皮膚化粧料は、塗布後に、水系皮膚化粧料の乾き際に、特に敏感肌の人が感じるむずむずした感覚（単に、むずむず感ということもある）の緩和効果を向上させる観点から、成分（Ｆ）として、水溶性高分子を含有することが好ましい。成分（Ｆ）は、水系皮膚化粧料を肌に塗布した後、水性皮膚化粧料の乾き際に感じるむずむずした感覚の緩和効果を向上させる観点から、水系皮膚化粧料中に０．０５〜０．５質量％であるのが好ましく、０．１０〜０．４０質量％がより好ましく、０．１５〜０．３５質量％がさらに好ましい。成分（Ｆ）としては、ヒドロキシエチルセルロース、アルキル変性をしてもよいカルボキシビニルポリマー、キサンタンガムなどが挙げられる。また、成分（Ｂ）と成分（Ｆ）の含有量の合計［（Ｂ）＋（Ｆ）］は、水系皮膚化粧料を肌に塗布した後、水系皮膚化粧料の乾き際に感じるむずむずした感覚の緩和効果、塗布後の肌のみずみずしさを向上させる観点から、水系皮膚化粧料中に０．１０〜１質量％含有するのが好ましく、０．１４〜０．９質量％含有するのがより好ましく、０．１８〜０．８質量％含有するのがさらに好ましい。 In addition, the water-based skin cosmetic of the present invention has a viewpoint of improving the mitigating effect of an irritating sensation (sometimes simply referred to as itching sensation) that is particularly felt by people with sensitive skin when the water-based skin cosmetic is dried after application. Therefore, it is preferable to contain a water-soluble polymer as the component (F). Component (F) is 0.05 to 0.00% in the aqueous skin cosmetic from the viewpoint of improving the effect of relieving the itching sensation felt when the aqueous skin cosmetic is dried after the aqueous skin cosmetic is applied to the skin. The content is preferably 5% by mass, more preferably 0.10 to 0.40% by mass, and still more preferably 0.15 to 0.35% by mass. Examples of the component (F) include hydroxyethyl cellulose, carboxyvinyl polymer that may be alkyl-modified, and xanthan gum. In addition, the total content of component (B) and component (F) [(B) + (F)] is an itching sensation that is felt when the water-based skin cosmetic is dried after the water-based skin cosmetic is applied to the skin. From the viewpoint of improving the skin relieving effect and the freshness of the skin after application, it is preferable to contain 0.10 to 1% by mass in the aqueous skin cosmetic, and more preferably 0.14 to 0.9% by mass. The content is preferably 0.18 to 0.8% by mass.
本発明の水系皮膚化粧料は、塗布後の肌のみずみずしさを向上させる観点から、外観が、透明であることが好ましい。また、透過度は、２０％以上であることが好ましい。ここで、透過度は、可視分光光度計ＵＶ−１８００（島津製作所社製）にて、測定波長５５０ｎｍ、光路長１０ｍｍにより測定できる。水系皮膚化粧料の具体例としては、ふき取り用化粧水等の化粧水、乳液などが挙げられる。
本発明の水系皮膚化粧料は、皮膚、中でも頭髪を除く皮膚、好ましくは顔、身体、手足等のいずれかに塗布することにより、使用することができる。
From the viewpoint of improving the freshness of the skin after application, the water-based skin cosmetic of the present invention preferably has a transparent appearance. Further, the transmittance is preferably 20% or more. Here, the transmittance can be measured with a visible spectrophotometer UV-1800 (manufactured by Shimadzu Corporation) at a measurement wavelength of 550 nm and an optical path length of 10 mm. Specific examples of the water-based skin cosmetics include skin lotions such as a skin lotion for wiping, and emulsions.
The water-based skin cosmetic of the present invention can be used by applying it to the skin, particularly the skin excluding the hair, preferably the face, body, limbs and the like.
本発明の水系皮膚化粧料は、前記成分の他、成分（Ｃ）を除く界面活性剤、成分（Ｄ）を除く多価アルコール、エタノール、ｐＨ調整剤、香料、植物抽出物、油剤等を含有することができる。 The aqueous skin cosmetic of the present invention contains, in addition to the above components, a surfactant excluding component (C), a polyhydric alcohol excluding component (D), ethanol, a pH adjuster, a fragrance, a plant extract, an oil, and the like. can do.
本発明の水系皮膚化粧料は、本発明の効果を損しない範囲で、エタノールを含有することができ、その含有量は、皮膚刺激性を抑制する観点から、水系皮膚化粧料中に３質量％以下が好ましく、２質量％以下がより好ましく、１質量％以下がさら好ましく、０．１質量％以下がよりさらに好ましく、含有しないことが好ましい。 The aqueous skin cosmetic of the present invention can contain ethanol as long as the effects of the present invention are not impaired, and the content thereof is 3% by mass in the aqueous skin cosmetic from the viewpoint of suppressing skin irritation. The following is preferable, 2 mass% or less is more preferable, 1 mass% or less is more preferable, 0.1 mass% or less is further more preferable, and it is preferable not to contain.
本発明の水系皮膚化粧料は、本発明の効果を損しない範囲で、油剤を含有することができ、その含有量は、透過度の高い透明な水系皮膚化粧料を得る観点から、水系皮膚化粧料中に２質量％以下が好ましく、１質量％以下がより好ましく、０．５質量％以下がさらに好ましく、０．１質量%以下がよりさらに好ましく、含有しないことが特に好ましい。ここで油剤とは、２５℃で液状の油剤のことをいい、炭化水素、エステル油、トリグリセライド、シリコーン系の油剤などが含まれる。 The water-based skin cosmetic of the present invention can contain an oil as long as the effects of the present invention are not impaired, and the content thereof is water-based skin cosmetic from the viewpoint of obtaining a transparent water-based skin cosmetic with high permeability. The content is preferably 2% by mass or less, more preferably 1% by mass or less, further preferably 0.5% by mass or less, still more preferably 0.1% by mass or less, and particularly preferably not contained. Here, the oil agent means an oil agent that is liquid at 25 ° C., and includes hydrocarbons, ester oils, triglycerides, silicone-based oil agents, and the like.
次に実施例を挙げて本発明を更に詳細に説明する。 EXAMPLES Next, an Example is given and this invention is demonstrated still in detail.
（数平均分子量の測定）
ポリエチレングリコールの数平均分子量は、以下のように測定する。
（測定装置・条件）
東ソー社製、一体型ＧＰＣ装置
装置：ＨＬＣ−８２２０ＧＰＣ
検出器：ＲＩ（示差屈折計）
カラム：ＴＳＫ−ｇｅｌ Ｇ５０００ＨｘＬ（７．８×３００ｍｍ）×１
Ｇ４０００ＨｘＬ（７．８×３００ｍｍ）×１
Ｇ３０００ＨｘＬ（７．８×３００ｍｍ）×１
Ｇ２０００ＨｘＬ（７．８×３００ｍｍ）×１
移動相：ＴＨＦ（テトラヒドロフラン）
流速：１．０ｍＬ／ｍｉｎ
設定温度：４０℃
注入量：１００μＬ（試料濃度：０．４％）
ポリスチレン（※）換算による数平均分子量を測定。
※ポリスチレン：東ソー社製、ＴＳＫ標準ポリスチレン
(Measurement of number average molecular weight)
The number average molecular weight of polyethylene glycol is measured as follows.
(Measurement equipment and conditions)
Tosoh's integrated GPC device: HLC-8220GPC
Detector: RI (differential refractometer)
Column: TSK-gel G5000HxL (7.8 × 300 mm) × 1
G4000HxL (7.8 × 300mm) × 1
G3000HxL (7.8 × 300mm) × 1
G2000HxL (7.8 × 300mm) × 1
Mobile phase: THF (tetrahydrofuran)
Flow rate: 1.0 mL / min
Set temperature: 40 ° C
Injection volume: 100 μL (sample concentration: 0.4%)
Measures the number average molecular weight in terms of polystyrene (*).
* Polystyrene: Tosoh Corporation, TSK standard polystyrene
実施例１〜１３及び比較例１〜８
表１〜表４の水系皮膚化粧料を製造し、透過度、外観、防腐性、感覚刺激性の緩和効果及び塗布後の肌のみずみずしさを評価した。結果を表１〜表４に示す。
Examples 1-13 and Comparative Examples 1-8
The water-based skin cosmetics shown in Tables 1 to 4 were produced, and the permeability, appearance, antiseptic properties, sensory irritation mitigating effects and freshness of the skin after application were evaluated. The results are shown in Tables 1 to 4.
＜化粧料の製造方法＞
実施例１〜９，１２，１３及び比較例１〜８は全成分を混合し、８０℃で２０分加熱攪拌を行った。その後、攪拌しながら２５℃まで冷却して水系皮膚化粧料を得た。実施例１０，１１は、成分（Ａ）、（Ｃ）及び油剤を８０℃で加熱撹拌し、油相を調整し、一方、それ以外の成分を８０℃で加熱撹拌し、均一に溶解させて水相を調整し、その後、前記油相を８０℃で加熱攪拌しながら、前記水相に滴下し、さらに２０分加熱攪拌した後、撹拌しながら２５℃になるまで冷却して水系皮膚化粧料を得た。
<Manufacturing method of cosmetics>
In Examples 1 to 9, 12, 13 and Comparative Examples 1 to 8, all the components were mixed and heated and stirred at 80 ° C. for 20 minutes. Then, it cooled to 25 degreeC, stirring, and obtained water-based skin cosmetics. In Examples 10 and 11, the components (A), (C) and the oil agent were heated and stirred at 80 ° C. to adjust the oil phase, while the other components were heated and stirred at 80 ° C. to dissolve uniformly. The aqueous phase is adjusted, and then the oily phase is added dropwise to the aqueous phase while being heated and stirred at 80 ° C., and further heated and stirred for 20 minutes. Got.
＜透過度＞
２５℃で、可視分光光度計ＵＶ−１８００（島津製作所社製）を用いて測定波長５５０ｎｍ、光道長１０ｍｍにより測定した。数値が高いほど透明な化粧料であること示す。
＜外観＞
目視により、評価を行った。
<Transparency>
The measurement was performed at 25 ° C. using a visible spectrophotometer UV-1800 (manufactured by Shimadzu Corporation) with a measurement wavelength of 550 nm and an optical path length of 10 mm. The higher the value, the clearer the cosmetic.
<Appearance>
Evaluation was performed visually.
＜防腐性＞
表１〜４の水系皮膚化粧料５０ｇに細菌用菌液（黄色ブドウ球菌、大腸菌群含有）を０．５ｍＬを加え、十分攪拌混合し、菌液含有水系皮膚化粧料を得た。滅菌したＬＰ希釈液（日本新薬社製）９ｍＬを含む試験管に、前記菌液含有水系皮膚化粧料を１ｍＬ加えて混合希釈液を調整した。その後、その混合希釈液０．１ｍＬをＳＣＤ寒天培地（日本新薬社製）の入ったプレートの平板表面にとり、滅菌したコンラージ棒で均一に塗抹した。その後、前記プレートを３２．５℃の恒温槽で静置培養し、形成されたコロニー（集落）を計数した。サンプリングは１日目、３日目、７日目に行った。
４；１、３、７日目でプレート上の菌数が（１０2ＣＦＵ/ｇ）以下であった。
３；１日目でプレート上の菌数が（１０2ＣＦＵ/ｇ）より多く、３、７日目でプレート上の菌数が（１０2ＣＦＵ/ｇ）以下であった。
２；１、３日目でプレート上の菌数が（１０2ＣＦＵ/ｇ）より多く、７日目でプレート上の菌数が（１０2ＣＦＵ/ｇ）以下であった。
１；１、３、７日目でプレート上の菌数が（１０2ＣＦＵ/ｇ）より多かった。若しくは、１、３日目のいずれかにおいて、菌数が（１０2ＣＦＵ/ｇ）以下に減少したが、それ以降の試験で、１度でも（１０2ＣＦＵ/ｇ）より多くなった。
<Antiseptic>
0.5 mL of bacterial liquid (containing Staphylococcus aureus and coliform group) was added to 50 g of aqueous skin cosmetics in Tables 1 to 4 and mixed thoroughly to obtain a bacterial liquid-containing aqueous skin cosmetic. To a test tube containing 9 mL of a sterilized LP diluted solution (manufactured by Nippon Shinyaku Co., Ltd.), 1 mL of the above-mentioned bacterial skin solution-containing aqueous skin cosmetic was added to prepare a mixed diluted solution. Thereafter, 0.1 mL of the mixed diluted solution was taken on the plate surface of a plate containing SCD agar medium (manufactured by Nippon Shinyaku Co., Ltd.) and smeared uniformly with a sterilized congeal stick. Thereafter, the plate was statically cultured in a constant temperature bath at 32.5 ° C., and the formed colonies (colonies) were counted. Sampling was performed on the first, third, and seventh days.
4: The number of bacteria on the plate was (10 2 CFU / g) or less on the first, third, and seventh days.
3: The number of bacteria on the plate was more than (10 2 CFU / g) on the first day, and the number of bacteria on the plate was (10 2 CFU / g) or less on the third and seventh days.
2: The number of bacteria on the plate was larger than (10 2 CFU / g) on the first and third days, and the number of bacteria on the plate was (10 2 CFU / g) or less on the seventh day.
On the 1st, 1st, 3rd, and 7th days, the number of bacteria on the plate was more than (10 2 CFU / g). Or, in any of 1, 3 day, the number of bacteria were reduced to less than (10 2 CFU / g), in subsequent tests, becomes greater than even (10 2 CFU / g) at once.
＜感覚刺激性の緩和効果＞
感覚刺激性の緩和効果として、以下のアンケートを行って評価した。
防腐剤スティンガー（防腐剤の皮膚刺激に感受性が高い人）５人が、化粧用コットンを用いて、表１〜４の水系皮膚化粧料を顔に塗布した。なお、化粧用コットンには、表１〜４の水系皮膚化粧料を含浸率１０００％となるように含浸させた。その後、５人から、水系皮膚化粧料を顔に塗布してから１０分間の間、水系皮膚化粧料を塗布する前と塗布した後の感覚の違いについて、フリーワードで回答を得た。回答のうち、最も回答の多かった、痛みとむずむず感（特に水系皮膚化粧料の乾き際のむずむず感）について、以下の基準に基づいて聞き取りを行い評価した。なお、５人のいずれの回答からも、痛みの回答がなかった場合は、痛みが「ない」と判定し、むずむず感についても同様に判定した。また、痛みがあっても、むずむず感がない場合は、むずむず感がないと判定し、むずむず感があっても、痛みがない場合は、痛みがないと判定した。
（１）痛み
痛みの強さは、痛みを感じないものを「ない」とし、痛みを感じる強さに応じて、「弱い」、「やや弱い」、「やや強い」、「強い」の５段階の基準（ない、弱い、やや弱い、やや強い、強い）で評価した。
５；だれも痛みがなかった。
４；５人中の痛みの強さの最大が「弱い」であった。
３；５人中の痛みの強さの最大が「やや弱い」であった。
２；５人中の痛みの強さの最大が「やや強い」であった。
１；５人中の痛みの強さの最大が「強い」であった。
（２）むずむず感
「（１）痛み」の「痛み」を「むずむず感」に変えて同様に評価した。
<Relief effect of sensory stimulation>
The following questionnaire was used to evaluate the sensory stimulant mitigation effect.
Five preservative stinger (persons who are highly sensitive to the skin irritation of the preservative) applied the aqueous skin cosmetics shown in Tables 1 to 4 to the face using cosmetic cotton. The cosmetic cotton was impregnated with the water-based skin cosmetics shown in Tables 1 to 4 so that the impregnation rate was 1000%. Thereafter, five people answered free words about the difference in sensation before and after applying the aqueous skin cosmetic for 10 minutes after applying the aqueous skin cosmetic to the face. Based on the following criteria, we evaluated the pain and itching sensation (especially when the water-based skin cosmetics were dried), which were the most frequently answered. In addition, when there was no pain answer from any of the five answers, it was determined that there was no pain, and the feeling of itching was similarly determined. Moreover, even if there was pain, when it did not feel itching, it was determined that there was no itching, and when there was itching but there was no pain, it was determined that there was no pain.
(1) Pain As for the intensity of pain, “no” is given to those that do not feel pain, and “weak”, “slightly weak”, “slightly strong”, and “strong” are selected according to the strength at which pain is felt. The criteria (not, weak, slightly weak, slightly strong, strong) were evaluated.
5: No one was painful.
4: The maximum pain intensity among 5 people was “weak”.
3: The maximum intensity of pain among 5 people was “slightly weak”.
2: The maximum pain intensity among the five was "slightly strong".
1: The maximum pain intensity among the five was "strong".
(2) Itching feeling “(1) Pain” in “Pain” was changed to “Itching feeling” and evaluated in the same manner.
＜塗布後の肌のみずみずしさ＞
化粧品専門パネラー５人が、前腕に表１〜４の各水系皮膚化粧料０．２ｍＬをとり、なじませた後の肌のみずみずしさを肌に残った皮膜感から評価した。皮膜感を感じる強さが弱いほど、優れた肌のみずみずしさを得られることを示す。
皮膜感の強さは、皮膜感を感じないものを「ない」とし、皮膜感を感じる強さに応じて、「弱い」、「やや弱い」、「やや強い」、「強い」の５段階の基準（ない、弱い、やや弱い、やや強い、強い）で評価した。
５；だれも皮膜感を感じなかった。
４；５人中の皮膜感の強さの最大が「弱い」であった。
３；５人中の皮膜感の強さの最大が「やや弱い」であった。
２；５人中の皮膜感の強さの最大が「やや強い」であった。
１；５人中の皮膜感の強さの最大が「強い」であった。
<Freshness of skin after application>
Five panelists specializing in cosmetics evaluated the freshness of the skin after applying 0.2 mL of each of the aqueous skin cosmetics shown in Tables 1 to 4 on the forearm from the feeling of the film remaining on the skin. It shows that the freshness of the excellent skin can be obtained as the strength for feeling the film is weak.
The strength of the film feeling is determined as “No” for those that do not feel the film feeling, and “weak”, “slightly weak”, “slightly strong”, and “strong” depending on the strength of feeling the film feeling. Evaluation was based on criteria (not, weak, slightly weak, slightly strong, strong).
5: Nobody felt a film feeling.
4: The maximum strength of the film feeling among 5 people was “weak”.
3: The maximum strength of the film feeling among 5 people was “slightly weak”.
2: The maximum strength of the film feeling among 5 people was “slightly strong”.
1: Maximum strength of film feeling among 5 people was “strong”.
表１〜表４より、本発明の（Ａ）、（Ｂ）、（Ｃ）、（Ｄ）及び（Ｅ）を含有し、〔（Ａ）／[（Ｂ）＋（Ｃ）］〕が０．１〜２．５又は０．５〜５の範囲にある水系皮膚化粧料は、透明〜半透明の外観で、（Ａ）成分の皮膚浸透性が抑制されており、感覚刺激性（痛みとむずむず感）が緩和されており、防腐性も良好であった。また、塗布後の肌がみずみずしい組成物であった。
一方、成分（Ｂ）及び（Ｃ）、または成分（Ｂ）を含有しないか（比較例１、２、３）、〔（Ａ）／[（Ｂ）＋（Ｃ）］〕が本発明の範囲外（比較例４、５、６、７、８）の化粧料は、防腐性が十分でないか、感覚刺激性があった。
From Table 1 to Table 4, it contains (A), (B), (C), (D) and (E) of the present invention, and [(A) / [(B) + (C)]] is 0. Water-based skin cosmetics in the range of 1 to 2.5 or 0.5 to 5 have a transparent to translucent appearance, the skin permeability of the component (A) is suppressed, and sensory irritation (pain and The feeling of tingling was eased, and the antiseptic property was also good. Moreover, it was a composition with fresh skin after application | coating.
On the other hand, the components (B) and (C), or the component (B) is not contained (Comparative Examples 1, 2, 3), [(A) / [(B) + (C)]] is within the scope of the present invention. The outer cosmetics (Comparative Examples 4, 5, 6, 7, and 8) had insufficient antiseptic properties or were sensory stimulating.
実施例１４（化粧水） Example 14 (skin lotion)
実施例１５（化粧水）
Claims (5)
（Ａ）（Ａ１）メチルパラベン及び／若しくはエチルパラベン、又は（Ａ２）フェノキシエタノール、
（Ｂ）数平均分子量３０００〜３００００のポリエチレングリコール、
（Ｃ）ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油及びポリオキシエチレンアルキルエーテルから選ばれる１種以上のノニオン界面活性剤、
（Ｄ）ジプロピレングリコール、１，３−ブチレングリコール及び１，３−プロパンジオールから選ばれる１種以上のジオール、
（Ｅ）水
を含有し、成分（Ｂ）と（Ｃ）の合計に対する成分（Ａ）の質量比〔（Ａ）／［（Ｂ）＋（Ｃ）］〕が、成分（Ａ）が（Ａ１）の場合は０．１以上２．５以下であり、成分（Ａ）が（Ａ２）の場合は０．５以上５以下である水系皮膚化粧料。 The following components (A), (B), (C), (D) and (E):
(A) (A1) methylparaben and / or ethylparaben, or (A2) phenoxyethanol,
(B) a polyethylene glycol having a number average molecular weight of 3000 to 30000,
(C) one or more nonionic surfactants selected from polyoxyethylene sorbitan fatty acid esters, polyoxyethylene hydrogenated castor oil, and polyoxyethylene alkyl ethers,
(D) one or more diols selected from dipropylene glycol, 1,3-butylene glycol and 1,3-propanediol,
(E) The mass ratio [(A) / [(B) + (C)]] of the component (A) with respect to the sum of the components (B) and (C) containing water and the component (A) is (A1 ) Is 0.1 to 2.5, and when the component (A) is (A2), the aqueous skin cosmetic is 0.5 to 5 inclusive.
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| JP2019019114A (en) * | 2017-07-20 | 2019-02-07 | ダイヤ製薬株式会社 | Hydrous composition, patch constituting hydrous composition, cosmetic or external skin pharmaceutical agent, and method for producing the same |
| JP2022040191A (en) * | 2017-07-20 | 2022-03-10 | ダイヤ製薬株式会社 | Water-containing composition, and patch, cosmetic, or external skin pharmaceutical, which comprises water-containing composition, as well as production methods thereof |
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| JP2022040191A (en) * | 2017-07-20 | 2022-03-10 | ダイヤ製薬株式会社 | Water-containing composition, and patch, cosmetic, or external skin pharmaceutical, which comprises water-containing composition, as well as production methods thereof |
| JP7340140B2 (en) | 2017-07-20 | 2023-09-07 | ダイヤ製薬株式会社 | Water-containing compositions, patches, cosmetics or dermatological medicines comprising the water-containing compositions, and methods for producing these |
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