CN105030610B - A kind of anti-apolexis composition and preparation method thereof - Google Patents
A kind of anti-apolexis composition and preparation method thereof Download PDFInfo
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- CN105030610B CN105030610B CN201510509228.8A CN201510509228A CN105030610B CN 105030610 B CN105030610 B CN 105030610B CN 201510509228 A CN201510509228 A CN 201510509228A CN 105030610 B CN105030610 B CN 105030610B
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Abstract
The present invention discloses a kind of anti-apolexis composition, comprising basic components and the anti-aging factor being scattered in the basic components, at least three kinds in soybean germ extract, wheat malt germ extract, safflower germ extracts, maize germ extract of the anti-aging factor.The present invention is by regarding at least three kinds in soybean germ extract, wheat malt germ extract, safflower germ extracts, maize germ extract as the anti-aging factor applied in anti-apolexis composition, at least three kinds in soybean germ extract, wheat malt germ extract, safflower germ extracts, maize germ extract produce synergistic effect on antisenility between each other, it can cooperate with and promote collagen synthesis, quickly smooth skin lines, repair impaired skin, so as to reach the purpose of delaying skin aging.
Description
Technical field
The present invention relates to cosmetic technical field, and in particular to a kind of anti-apolexis composition and preparation method thereof.
Background technology
Aging is not disease, but a kind of physiological phenomenon.Skin is located at body surface, is most significant device during body aging
One of official.The principal character of mankind aging has：Thinning of skin, occur wrinkle, skin elasticity reduction, pigment deposition, muscular atrophy,
Skin moisturizing ability decline etc..People's life at present is relatively stable more plentiful, and the beautification to appearance requires more and more higher, and people wish
Hope " perpetual youth ", therefore find the various methods for preventing aging by every possible means, such as made up using Kangshuaining mixture and anti-aging
Product.Some the chemical synthesis Kangshuaining mixtures clinically used, although there is certain retarding action to aging, these medicines pair
The body of patient also result in very big injury.The anti-aging effects of commercially available anti-aging cosmetics are typically poor, Huo Zheqi
In contain various chemical synthesis parahormones, injury is also easily caused to body, it is difficult to meet the needs of esthete.
The content of the invention
It is an object of the present invention to provide a kind of anti-aging cosmetics, the anti-aging effects of the anti-aging cosmetics are good
And have no toxic side effect.
It is another object of the present invention to provide a kind of preparation method of above-mentioned anti-apolexis composition, can be made anti-ageing
The anti-apolexis composition of old excellent effect.
To use following technical scheme up to this purpose, the present invention：
A kind of anti-apolexis composition is provided, comprising basic components and the anti-aging being scattered in the basic components because
Son, the anti-aging factor are selected from soybean germ extract, wheat malt germ extract, safflower germ extracts, maize germ and carried
Take at least three kinds in thing.
Above-mentioned soybean germ extract is called big bean sprout extract, is to extract to obtain from soybean germ, because soybean exists
Multivitamin such as vitamin C, vitamin B2 equal size is greatly improved in germination process, and a variety of high molecular weight proteins are also decomposed into more
The amino acid being easily absorbed by the body such as lysine, the soybean germ extract outer used time to improving obscure colour of skin positive effect, its
Contained " phytoestrogen " isoflavones to anti-light aging and the positive effect of natural aging, and can effectively adjust skin
Secreting function, skin smooth, exquisiteness, tender, high resilience can be made；
Above-mentioned wheat malt germ extract extracts from wheat embryo, is a kind of colourless to lurid transparency liquid, its
PH value at 25 DEG C is 6~8.Wheat embryo is the nutrition treasure-house that wheat (Triticum aestivum Linn.) breeds life,
It is Wheat Species nutritive value highest part, contains the mineral matter such as abundant protein, vitamin and calcium, iron, zinc, tin and micro
Element.The dissolubility and good penetrability of wheat gluten in wheat malt germ extract, there is humectant, can quickly smooth skin
Microgroove, nutrition simultaneously nurse one's health skin；Vitamin C in wheat malt germ extract can be synthesized with stimulation collagen, promote wound to be cured
Close, increase skin elasticity, strengthen skin resistance；Vitamin B complex in wheat malt germ extract, which can cooperate with, maintains skin to be good for
Health, skin resistance daylight injury is helped, promotes the function of immune system, promotes cell growth and division, repair impaired skin；It is small
Mineral matter element in wheat germ extract can also nutrition and the impaired skin of reparation.
Above-mentioned safflower germ extracts are obtained from the safflower plumule being grown in free of contamination environment, are had powerful
Ageing resistace.Safflower plumule is rich in more rich phenolic compound, amino acid and alpha-tocopherol than Semen Carthami.Safflower plumule
The 8- hydroxylation arctigenins contained in extract have cell propagation, differentiation and antioxidation activity, and proline is that collagen closes
Into precursor, Collagen I and Collagen III synthesis can be promoted, alpha-tocopherol is one well-known anti-
Oxidant, it can effectively remove free radical.Therefore the safflower germ extracts outer used time has full effect anti-aging, natural protection-anti-
The effect aoxidize, protect sensitive and fragile skin, reinforced skin barrier.
Above-mentioned maize germ extract is obtained from maize germ, contains Co-Q10, phytic acid, adenine kind derivative
Etc. a variety of vital activity elements, the skin disease such as Co-Q10 optic hyperesthesia disease, pigmentation disease works well, and its radioresistance, suppresses
The effect of 5- reductases clearly, is mainly used in crease-resistant, anti-aging, removes the cosmetics of free radical；Phytic acid has to a variety of enzymes
Good inhibiting effect, available for whitening class, anti-aging class cosmetics；Exogenous adenine kind material has hormone-like effect,
Antioxidation can be played to animals and plants body, cell division, differentiation and growth can be promoted, delay protein degradation, delay
Organ senescence, promote body tissue healing.
The extraction of above-mentioned soybean germ extract, wheat malt germ extract, safflower germ extracts, maize germ extract
Method is prior art, be will not be repeated here.
Specifically, above-mentioned anti-apolexis composition includes 5~15 parts of anti-aging factors, wherein, the anti-aging factor
It is made up of following at least three kinds of components：
The content of the soybean germ extract be 0.1~6 part, such as 0.2 part, 0.3 part, 0.5 part, 0.8 part, 1 part,
1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, 5.5 parts；The content of the wheat malt germ extract be 0.1~
3 parts, for example, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.5 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2
Part, 2.5 parts, 2.8 parts；The content of the safflower germ extracts be 0.1~3 part, such as 0.15 part, 0.2 part, 0.25 part, 0.3
Part, 0.35 part, 0.5 part, 0.8 part, 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.5 parts, 2.8 parts；The maize germ extraction
The content of thing be 0.1~3 part, 0.15 part, 0.2 part, 0.25 part, 0.3 part, 0.35 part, 0.5 part, 0.8 part, 1 part, 1.2 parts, 1.5
Part, 1.8 parts, 2 parts, 2.5 parts, 2.8 parts.
As the preferred scheme of the present invention, the anti-aging factor is by soybean germ extract, wheat malt germ extract, red
Flower germ extracts composition, the soybean germ extract, wheat malt germ extract, the weight ratio of safflower germ extracts are (1
~6):(1~3):(1~3), more preferably 3:1:1.
As another preferred scheme of the present invention, the anti-aging factor is carried by soybean germ extract, wheat embryo
Take thing, maize germ extract composition, the soybean germ extract, wheat malt germ extract, the weight of maize germ extract
It is (1~6) to measure ratio:(1~3):(1~3), more preferably 3:1:1.
The present invention by by the soybean germ extract, the wheat malt germ extract, the safflower germ extracts,
The proportioning of the maize germ extract optimizes, and the synergistic effect on antisenility of the anti-aging factor is reached maximum, is ensureing
While the anti-apolexis composition of the present invention has good anti-aging effects, make the production cost of anti-apolexis composition optimal.
The present invention is by by anti-aging factor soybean germ extract, wheat malt germ extract, safflower germ extracts, jade
At least three kinds of combination applications in rice germ extracts are in anti-apolexis composition, soybean germ extract, wheat embryo extraction
At least three kinds in thing, safflower germ extracts produce synergistic effect on antisenility between each other, when it is used for skin surface, can assist
With promotion collagen synthesis, skin lines, the impaired skin of reparation are quickly smoothed, so as to reach the purpose of delaying skin aging.
Specifically, the basic components in above-mentioned anti-apolexis composition also include emulsifying agent；Emulsifying agent is that emulsus is made up
Most widely used a kind of formulation in product.The present invention by by emulsifying agent add anti-apolexis composition in, can by stirring or
Emulsifying effect is stable to be formed by the liquid complete miscibility of the not phase mixing of two or more in anti-apolexis composition
Emulsion.
As the preferred scheme of the present invention, by weight, the emulsifying agent include 2.8~4 parts of cetostearyl alcohols with
Cetostearyl alcohol and 0.7~1 part of PEG-20 stearate are included in PEG-20 stearates, i.e. anti-apolexis composition.Wherein, whale
Wax stearyl alcohol also known as cetostearyl alcohol, molecular formula C16H34O, have and suppress greasy feeling, reduce wax class raw material stickiness, stabilize
Cosmetic gel etc. acts on, suitable for all kinds of cosmetics, particularly suitable for cream and emulsion.PEG-20 stearates also known as poly-
Glyceryl triisostearate
(Polyglyceryl-2Triisostearate), No. CAS is 120486-24-0, is a kind of faint yellow or yellow
The viscous liquid of color, compared with nonionic polyoxyethylene surfactant, PEG-20 stearates show fabulous oxidation
Stability and pH stability, compared with sucrose, glycerine, sorbitan ester etc., PEG-20 stearates have fabulous heat steady
Qualitative, PEG-20 stearates also act as emollient in addition to as emulsifying agent, to the scattered of inorganic particle, pigment etc.
Property is superior, and good with the intermiscibility of other oil components, oxidation stability is good.Cetostearyl alcohol combines with PEG-20 stearates
Added as emulsifying agent in anti-apolexis composition, make anti-apolexis composition that there is good emulsification.
As the preferred scheme of the present invention, the weight ratio of the cetostearyl alcohol and the PEG-20 stearates for (2~
4):(1~3), such as 2:1、1:1、2:3、3:1、3:2、4:3, more preferably 4:1；The present invention to anti-aging by combining
The proportioning of cetostearyl alcohol and PEG-20 stearates in thing optimizes, to realize to the stability of anti-apolexis composition and
Production cost is controlled.
As the preferred scheme of the present invention, by weight, the emulsifying agent also includes 1.2~6 parts of cetostearyl alcohol olives
Olive oleate and the smooth olive oleate of 0.8~4 portion of sorb；The cetostearyl alcohol olive oleate can strengthen the final guarantor of product
It is moist, there is certain film forming, skin barrier can be made complete, good moisturizing and nourishing, reparation, anti-aging effects, stable, sustained release are lived
Property composition.The smooth olive oleate of sorb also known as the smooth single olive oleate of sorb, English name D-Glucitol, Isosorbide-5-Nitrae-
Anhydro-, 6-monoester with olive oil fattyacids, No. CAS is 223706-40-9, is a kind of alcohol ester
Type nonionic surfactant, there is excellent scattered, emulsification, lubricating ability, emulsifying agent, dispersant, stable emulsifying can be used as
Agent is applied to cosmetic field.Cetostearyl alcohol olive oleate combines with the smooth olive oleate of sorb to be used to resist as emulsifying agent
In anti-aging composition, make anti-apolexis composition that there is good emulsification, peptizaiton.
As the preferred scheme of the present invention, the cetostearyl alcohol olive oleate and the smooth olive oleate of the sorb
Weight ratio is (1~3):(1~2), such as 1:1、1:2、2:1、3:1, more preferably 3:2；The present invention is by anti-aging
The proportioning of cetostearyl alcohol olive oleate and the smooth olive oleate of sorb in composition optimizes, to realize to anti-aging
The stability and production cost of composition are controlled.
As the preferred scheme of the present invention, by weight, the emulsifying agent also includes 0.02~0.25 part of polysorbate
Ester -20 and 0.015~0.2 part of smooth isostearate of sorb；Wherein, polysorbate -20 also known as Tween-20, No. CAS is
9005-64-5, molecular formula C58H114O26, its structural formula is shown in Formulas I；Polysorbate -20 is a kind of hydrophilic emulsifier, simultaneously
And a kind of thickener, belong to bay acid derivative, there is the purposes such as emulsification, moistening, cleaning；The smooth isostearate of sorb also known as
Single Arlacel 987 (Sorbitan isooctadecanoate), No. CAS is 71902-01-7, and molecular formula is
C24H46O6, molecular structural formula is shown in Formula II.The present invention by polysorbate -20 and the smooth isostearate of sorb by introducing anti-aging
Optimize in composition and to polysorbate -20 and the content of the smooth isostearate of sorb, equally change to a certain extent
The stability of anti-apolexis composition is entered.
Specifically, the basic components also include thickener；Thickener by with surfactant formed rod-shaped micelle, with
Water acts on forming the purpose that three-dimensional aquation network structure or the macromolecular backbone using itself etc. make system reach thickening.
As the preferred scheme of the present invention, by weight, the thickener includes 0.4~1 part of docosyl alcohol, 0.25~1
Part cetostearyl alcohol, 0.12~1 part of acrylamide dimethyltaurine ammonium/methacrylic acid copolymer of docosyl alcohol polyethers -25 with
And 0.2~3 part of polyacrylate -13.Wherein, docosyl alcohol (Behenyl Alcohol) is called that behenic acid, mountain Yu is sour, flat oil
Acid, behenic acid, behenic acid, No. CAS is 661-19-8, molecular formula C22H46O, exist generally in the form of glyceride
In hardening rape oil and hardening fish oil, also there is a small amount of presence in peanut oil, rapeseed oil, mustard oil, be alternatively arranged as emollient, be used for
Skin conditioner, cosmetic emulsion, skin products, ointment are medium；Cetostearyl alcohol with PEG-20 stearates except combining as emulsification
Outside agent, thickener is alternatively arranged as；Acrylamide dimethyltaurine ammonium/methacrylic acid copolymer of docosyl alcohol polyethers -25 is
A kind of excellent thickener of stability；Polyacrylate -13 (POLYACRYLATE-13), in addition to as thickener, also
Epithelium binder can be used as, is advantageous to protect skin.The present invention passes through from docosyl alcohol, cetostearyl alcohol, acrylamide diformazan
Base taurine ammonium/methacrylic acid copolymer of docosyl alcohol polyethers -25 and the compounding of polyacrylate -13 are used as anti-apolexis composition
Thickener, and the content of each component is optimized, to increase the toughness of anti-apolexis composition and stability.
Specifically, the basic components also include emollient so that anti-apolexis composition can well moistening skin, profit
Sliding skin, protection and softening skin, moisture and the other active components such as anti-aging factor stopping in skin can also be improved in addition
The time is stayed, strengthens the anti-aging effects of anti-apolexis composition.
As the present invention preferred scheme, by weight, the emollient include 1~5 part of tristearin, 0.5~3 part
Cetanol palmitate, 7~10 parts of caprylic/capric triglycerides, 6.7~15 parts of isohexadecanes.Wherein, tristearin
(glycerol tristearate), also known as stearic, tristearin and glycerol tristearate, it is present in animal and plant fat
In oil, available for soap system, candle and cosmetics；Cetanol palmitate (Cetyl Palmitate) derives from plant, is
A kind of alcohol ester type nonionic surfactant, have it is excellent emulsify, disperse, solubilising, lubricating ability, as emulsifying agent, emulsification
Stabilizer application, as emollient, conditioner etc., applied to personal care field；Caprylic/capric triglyceride (GREOIL
GTCC be) a kind of derivative that there is the high tasteless grease clearly spent, belong to palm oil or coconut oil, vegetable formal name be palm oil/
Coconut oil derivative, good effect is played to the uniform and smooth of cosmetics, makes skin lubrication is glossy to be easy to be inhaled by skin
Receive, because there is compatible feature it and human body skin, so also being adapted for Oily use, and pore will not be blocked, it has
Non-greasy texture, its extensibility can be improved by adding in creams or emulsion, had lubrication and made the soft effect of skin, and have filtering
The function of ultraviolet light；Isohexadecane (Isocetane), also known as 2,2,4,4,6,8,8- heptamethylnonanes, No. CAS is 60908-
77-2, is a kind of alkane of height collateralization, its excellent performance and very economic, has excellent toxicological security.The present invention
By the way that tristearin, cetanol palmitate, caprylic/capric triglyceride, isohexadecane composite usage are combined in anti-aging
In thing, the emollient of anti-apolexis composition can be increased, extend the stop of the anti-aging factor and other moisturizing ingredients on skin
Time, strengthen the anti-aging effects of anti-apolexis composition.
Specifically, the basic components also include NMF, anti-apolexis composition is had moistening effect.
As the present invention preferred scheme, by weight, the NMF include 1~5 part of dipropylene glycol, 0.5~2 part
Glycerine, 0.12~1.5 part of polyisobutene, 5~15 parts of butanediols.Wherein, dipropylene glycol, also known as dipropylene glycol, dipropyl two
Alcohol, DPG, molecular formula C6H14O3, it is many essence and flavoring agents and the optimal solvent of cosmetic applications, has good
Moisture, oil and hydrocarbon molten ability, and smell is slight altogether, to skin irritation very little, toxicity is very low, isomerism
Body is evenly distributed unanimously, and quality is splendid；Glycerine is the moisturizing ingredient commonly used in cosmetics, and basic components, have it is extremely strong
Hygroscopicity, it is wiped on skin, can form one layer of glycerine film, and cut-off air is invaded into making the moisture in skin be not easy to evaporate, also
Moisture in absorbable air carrys out skin care, effectively prevents chapped skin；Polyisobutene (Polyisobutylene, PIB),
It is through being a kind of typical saturation linear polymer, No. CAS is 9003-27- just from polymer made from polymerization as isobutene
4；Butanediol (Butylene Glycol) alias is called：1,3- dihydroxy butane, it is one kind of polyalcohol, in cosmetics often
Do NMF and solvent uses, in terms of moisturizing, because butanediol is small molecule moisturizing composition, so grabbing water ratio very little, together
When also have certain bacteriostasis.The present invention from dipropylene glycol, glycerine, polyisobutene, butanediol compounding by being used as moisturizing
Agent, and the content of each component in NMF is optimized, extend the anti-aging factor on skin by increasing moisture retention
Action time, the anti-aging effects of collaboration enhancing anti-apolexis composition.
Specifically, the basic components also include preservative and anti-corrosive aids, to prevent anti-apolexis composition in production, storage
Deposit period germ contamination or become sour, extend the shelf-life of anti-apolexis composition, and preservative and anti-corrosive aids compounding
Use, antiseptic effect is more preferably.
As the preferred scheme of the present invention, by weight, the preservative includes 0.2~0.9 part of Phenoxyethanol, 0.01
~0.06 part of iodine propilolic alcohol butyl mephenesin Carbamate and 0.004~0.8 part of methylisothiazolinone；Wherein, Phenoxyethanol
(Phenoxyaethanolum) chemical formula is C8H10O2, it is preservative common in cosmetics, belongs to relatively safe
One of preservative, there is broad spectrum antibiotic activity, there is stronger killing action to Pseudomonas aeruginosa, to other gram-negative bacterias and sun
Property bacterial action is weaker；Iodine propilolic alcohol butyl mephenesin Carbamate (IPBC) is a kind of compound for being used to kill der Pilz, is added
In anti-apolexis composition, it can prevent from making the color of anti-apolexis composition change due to the growth of mould during storage,
Extend the shelf-life of anti-apolexis composition；Methylisothiazolinone (MIT) also known as MIT, No. CAS
For 2682-20-4, molecular formula C4H5NOS, methylisothiazolinone are a kind of heat-resisting waterborne preservatives, for suppressing micro- life
The growth of thing has good effect, can suppress the growth of bacterium, fungi, mould and mould, can be directly added into personal nursing
The fields such as articles for use, cosmetics.The present invention is by selecting above-mentioned three kinds of preservative compounding uses and to it in anti-apolexis composition
Content optimize, can effectively suppress and kill the bacterium in anti-apolexis composition, fungi, mould and mould, extend anti-
The shelf-life of anti-aging composition.
As the preferred scheme of the present invention, by weight, it is sweet that the anti-corrosive aids include 0.02~0.1 part of ethylhexyl
Oil and 0.2~1 part of propane diols.Sensiva SC50 (UN-121) is a kind of novel anticorrosion auxiliary agent, and a kind of spreading property
Moderate emollient, NMF and wetting agent, there can be soft and smooth skin sense again while improving and being formulated moisturizing effect, add
In some cream systems, can solve cream absorb it is slow, it is tacky and the shortcomings that whitewash etc. in skin sense；Sebum in human sweat and
The caused material in the presence of gram-positive bacteria such as epidermal cell to come off has a unhappy smell, and Sensiva SC50
The growth and breeding of bacterium for causing peculiar smell can effectively be suppressed, while do not influence the skin flora beneficial to human body, so as to play gas
The effect that taste suppresses；Sensiva SC50 can also the preservative such as the above-mentioned Phenoxyethanol of synergy, methylisothiazolinone, so as to reduce
Dosage of the foregoing preservatives in anti-apolexis composition, use the anti-apolexis composition that loss of capital is invented safer；Propane diols
(Propylene Glycol) is used as moisture retention and solvent extensively in cosmetics, it is also possible to makees anti-corrosive aids.The present invention is logical
Cross and be used as anti-corrosive aids from Sensiva SC50 and propane diols compounding, can combine anti-aging with synergy foregoing preservatives
Thing keeps reducing the dosage of foregoing preservatives while good antiseptic property.
Specifically, the basic components also include conditioner；For adjust wetability, the fluidity of anti-apolexis composition with
And the compatibility between each oil-based liquid.
As the present invention preferred scheme, by weight, the conditioner include 2.5~5 parts of dimethyl silicone polymers,
1~5 part of phenyl trimethicone, 2.5~10 parts of glycine betaines and 0.2~5 part of polyvinylpyrrolidone.Wherein, poly- two
The Primary Speciation dimethyl ring body siloxanes of methylsiloxane is using dimethyldichlorosilane as primary raw material, is closed by hydrolysis
Into using silica (Si-O) key as main chain, the organic and inorganic compound of organic group, Primary Speciation diformazan are directly connected on silicon atom
Ring-type is presented in basic ring body siloxane molecule structure, mainly including hexamethyl cyclotrisiloxane (D3), octamethylcy-clotetrasiloxane
(D4), decamethylcyclopentaandoxane (D5), the siloxanes of ten diformazan basic ring six (D6), hexamethyl cyclotrisiloxane (D3), prestox
Cyclotetrasiloxane (D4), decamethylcyclopentaandoxane (D5) or the siloxanes of ten diformazan basic ring six (D6)；Dimethyl silicone polymer
Characteristic with liquid, thus be easy to it is applied on skin, be coated on skin have silk as sense of touch, have moisturizing property
Matter, there is moistening skin and water lock function, wound healing can also be promoted, improve skin scar；Phenyl trimethicone
CAS is 195868-36-1, and molecular formula is (C9H14O2Si2)nC6H18OSi2, be a kind of skin sense lubrication, salubrious high-grade oiliness into
Point, it is good with the compatibility of other greases, skin lubrication, moisturizing are made, moisture feeling is strong, non-greasy, and can make other components in formula
Greasy feeling reduce, be extraordinary emollient, while also there is extraordinary water-proof function, available for most skin-protection products
In, such as：Face cream, suncream, anti-sweat deodorising product, color make-up product；Glycine betaine also known as dodecyldimethylammonium hydroxide inner salt, beet
Element, betaine, ethanoic acid hydroxide inner salt, it is a kind of alkaline matter, there is very strong performance of keeping humidity；Polyvinyl pyrrole
Alkanone (polyvinyl pyrrolidone) abbreviation PVP, is a kind of non-ionic macromolecule compound, has extremely low toxicity
And physiological inertia, it is non-stimulated to skin, eyes, and institute is very safe for cosmetics etc., and polyvinylpyrrolidone has good
Dispersiveness and film forming, there is protecting colloid in emulsion, for that can strengthen moistening and lubrication effect in cream, white class cosmetics
Fruit.The present invention is by the way that dimethyl silicone polymer, phenyl trimethicone, glycine betaine and polyvinylpyrrolidone are compounded
Optimized using as conditioner, and to the content of each component, with to the moisture retention of anti-apolexis composition, emollient, stably
Property is further adjusted.
As the present invention preferred scheme, by weight, the basic components also comprising 0.1~1 part of pigment, 0.03~
1 part of essence and 40~50 parts of deionized waters, pigment are used to adjust the color of anti-apolexis composition, essence for adjusting anti-aging
The smell of composition, deionized water are used for the viscosity for adjusting anti-apolexis composition, anti-apolexis composition is had good use
Experience at family.
The present invention also provides a kind of preparation method of above-mentioned anti-apolexis composition, there is provided basic components and described anti-ageing
The old factor；The basic components and the anti-aging factor are well mixed, the anti-apolexis composition is made.
The excellent anti-apolexis composition of anti-aging effects can be made by using above-mentioned preparation method in the present invention.
Specifically, above-mentioned preparation method comprises the steps of：
(1) by weight by 1~5 part of dipropylene glycol, 0.5~2 part of glycerine, 2.5~10 parts of glycine betaines and 40~47 parts
Deionized water is well mixed, and the first mixture is made, and 0.12~1 part of acrylamide dimethyl is added into first mixture
Taurine ammonium/the methacrylic acid copolymer of docosyl alcohol polyethers -25,5~15 parts of anti-aging factors, system are added after being well mixed
Obtain the second mixture；
(2) by the mixture being made up of 2.8~4 parts of cetostearyl alcohols and 0.7~1 part of PEG-20 stearate, 1.2~6
Mixture that part cetostearyl alcohol olive oleate forms with the smooth olive oleate of 0.8~4 portion of sorb, 0.4~1 part of docosyl alcohol,
0.25~1 part of cetostearyl alcohol, 1~5 part of tristearin, 0.5~3 part of cetanol palmitate, 2.5~5 parts of poly dimethyl silicon
Oxygen alkane, 7~10 parts of caprylic/capric triglycerides, 3~5 parts of phenyl trimethicones and 5.5~10 parts of isohexadecanes mix
Close uniformly and melt completely, the 3rd mixture is made；
3rd mixture is added in second mixture, the 4th mixture is made；
(3) successively will be by 0.2~3 part of polyacrylate -13,0.12~1.5 part of polyisobutene, 0.02~0.25 part of poly- mountain
- 20,0.015~0.2 parts of smooth isostearates of sorb of pears alcohol ester, 0.02~0.25 part of deionized water and 1.2~5 parts different 16
The mixture of alkane composition, the mixture being made up of 0.2~5 part of polyvinylpyrrolidone, 4~10 parts of butanediols, by 0.2~0.9
Part Phenoxyethanol, 0.02~0.1 part of Sensiva SC50,0.01~0.06 part of iodine propilolic alcohol butyl mephenesin Carbamate, 0.2~1 part
The mixture of propane diols and 1~5 part of butanediol composition, by 0.004~0.8 part of methylisothiazolinone, 0.1~1 part of pigment
And in the mixture and 0.03~1 part of essence addition the 4th mixture of 0.05~1 part of deionized water composition, institute is made
State anti-apolexis composition；
Wherein, by weight, the anti-aging factor is made up of following at least three kinds of components：
Wherein, in the mixture of 3.5~5 parts of cetostearyl alcohols and PEG-20 stearates, the cetostearyl alcohol
Weight ratio with the PEG-20 stearates is (2~4):(1~3), preferably 4:1；
Wherein, it is described in the mixture of 2~10 parts of cetostearyl alcohol olive oleates and the smooth olive oleate of sorb
The weight ratio of cetostearyl alcohol olive oleate and the smooth olive oleate of the sorb is (1~3):(1~2), preferably 3:2；
As the preferred scheme of the present invention, the specific implementation step of step (1) is：By weight successively by dipropylene glycol,
Glycerine, glycine betaine and deionized water are added in emulsifying pot, obtained first mixture after emulsifying, past under processing condition
Acrylamide dimethyltaurine ammonium/methacrylic acid copolymer of docosyl alcohol polyethers -25 is slowly added in first mixture,
The emulsifying 5min under 40rpm speed, the anti-aging factor is added after well mixed, 85 are warming up under 40rpm speed
~88 DEG C and it is incubated, the second mixture is made；The emulsifying pot is vacuum emulsifying pot, above-mentioned first mixture be
It is made under the conditions of high speed homogenization, after acrylamide dimethyltaurine ammonium/methacrylic acid copolymer of docosyl alcohol polyethers -25 adds
The low speed emulsifying under 40rpm speed.
As the preferred scheme of the present invention, the specific implementation step of step (2) is：By weight successively by cetostearyl alcohol
The mixing of mixture, cetostearyl alcohol olive oleate olive oleate composition smooth with sorb with PEG-20 stearates composition
Thing, docosyl alcohol, cetostearyl alcohol, tristearin, cetanol palmitate, dimethyl silicone polymer, caprylic/capric glycerine three
Ester, phenyl trimethicone and isohexadecane add stirring in oil phase pot and are warming up to 80~83 DEG C to melting completely, make
Obtain the 3rd mixture；
Second mixture is stirred with 50rpm mixing speed, and the 3rd mixture in oil phase pot is added
In second mixture, emulsifying (high speed) 6min, is then stirred under 40rpm mixing speeds under 30rpm mixing speeds
5min is mixed, 40rpm speed is kept after cooling, the 4th mixture is made；
As the preferred scheme of the present invention, step (3) specifically comprises the steps of：
(3a) under the conditions of 63~65 DEG C, homogeneous (low speed) will by polyacrylate -13, polyisobutene, polysorbate -
20th, the mixture of the smooth isostearate of sorb, deionized water and isohexadecane composition is slowly added in the 4th mixture,
Stir under 40rpm mixing speeds, vacuumized after cooling, the 5th mixture is made；
(3b) polyvinylpyrrolidone after butanediol premix with using 800 mesh filter-cloth filterings, then in 48~50 DEG C of conditions
It is lower to add in the 5th mixture, stir under 35rpm mixing speeds, vacuumized after cooling, the 6th mixture is made；
(3c) Phenoxyethanol, Sensiva SC50, iodine propilolic alcohol butyl mephenesin Carbamate, propane diols and butanediol premix
Afterwards, added at 43~45 DEG C in the 6th mixture, stir under 35rpm mixing speeds, vacuumized after cooling, it is mixed to be made the 7th
Compound；
(3d) adds methylisothiazolinone, pigment and deionized water in the 7th mixture at 40 DEG C, 30rpm
5min is stirred under mixing speed and is vacuumized, the 8th mixture is made；
(3e) adds essence in the 8th mixture, is stirred under 30rpm mixing speeds, and the anti-aging is made
Composition.
In above-mentioned steps (3a), first by weight by polyacrylate -13, polyisobutene, polysorbate -20, sorb
Smooth isostearate, deionized water mixing, then the mixture is mixed with isohexadecane, then just add in the 4th mixture；
In above-mentioned steps (3b), polyvinylpyrrolidone is made with butanediol using following methods premix：
Polyvinylpyrrolidone is slowly added to by weight in the butanediol that quickly stirs, quick stirring to polyethylene pyrrole
Pyrrolidone dissolving is complete.
In above-mentioned steps (3c), Phenoxyethanol, Sensiva SC50, iodine propilolic alcohol butyl mephenesin Carbamate, propane diols and
Butanediol is made using following methods premix：
By weight respectively by Phenoxyethanol and Sensiva SC50 compounding, iodine propilolic alcohol butyl mephenesin Carbamate and propane diols
Compounding, then stirs both compounds with butanediol.
Homogeneous in above-mentioned preparation method referred to carrying out homogeneous at different speeds, and emulsifying is referred in homogeneous
Under the conditions of emulsified, both are prior art, be will not be repeated here.
Preparation process condition is optimized in the above-mentioned preparation method of the present invention, is ensureing obtained anti-aging group
Compound makes production cost, production time and other energy consumptions of anti-apolexis composition reach minimum while having good quality.
Beneficial effects of the present invention are：The present invention provides a kind of anti-apolexis composition, by by anti-aging factor soybean embryo
At least three kinds of combination applications in bud extract, wheat malt germ extract, safflower germ extracts, maize germ extract are in anti-
In anti-aging composition, in soybean germ extract, wheat malt germ extract, safflower germ extracts, maize germ extract
At least three kinds produce synergistic effect on antisenility between each other, can cooperate with and promote collagen synthesis, quickly smooth skin lines, repair
Skin is damaged again, so as to reach the purpose of delaying skin aging.
Figure of description
Fig. 1 is the curve map of the moisture relative increase rate of the embodiment of the present invention.
Fig. 2 is the curve map of the relative percentage of water loss of the embodiment of the present invention.
Fig. 3 is the block diagram of the Collagen I change in concentration of the embodiment of the present invention.
Embodiment
Technical scheme is further illustrated below by embodiment.
Unless specific instructions, various raw materials of the invention are commercially available buys, or is prepared according to the conventional method of this area
Obtain.
Embodiment 1
First that C phases, D phases, E phases is prefabricated standby, method for prefabricating is as follows：
C phases：First by weight by polyacrylate -13, polyisobutene, polysorbate -20, the smooth isostearic acid of sorb
Ester, deionized water mixing, then the mixture is mixed evenly with isohexadecane, cover standby；
D phases：Polyvinylpyrrolidone is slowly added in the butanediol that quickly stirs, quick stirring to polyvinylpyrrolidine
Ketone dissolving is complete, covers standby；
E phases：Phenoxyethanol is mixed with Sensiva SC50 respectively by weight, by iodine propilolic alcohol butyl mephenesin Carbamate with
Mixed with propylene glycol, then both mixtures are stirred with butanediol, covered standby；
The preparation method of anti-apolexis composition is as follows：
B1 phase materials are sequentially added to the vacuum emulsifying pot of cleaning by weight, do not open stirring, it is high to open emulsification pot
The fast emulsifying and acrylamide dimethyltaurine ammonium/methacrylic acid of docosyl alcohol polyethers -25 being slowly spilled into B2 phases is total to
Polymers (avoids the agglomerating caking of acrylamide dimethyltaurine ammonium/methacrylic acid copolymer of docosyl alcohol polyethers -25 from adding, kept away
Exempt from it to be bonded on pot wall and agitating paddle), the acrylamide dimethyltaurine ammonium/methacrylic acid copolymer of docosyl alcohol polyethers -25
Stirring 40rpm is opened after addition and opens low speed emulsifying 5 minutes, the anti-aging factor is then added, is warming up under 40rpm stirring degree
85~88 DEG C, insulated and stirred；
A phase materials are added into the stirring of oil phase pot and are warming up to 80~83 DEG C to melting completely；
B1B2 phases are stirred under 50rpm stirrings, A phases are pumped into B1B2 phases, A phases continue 2 points of stirring after exhausting
Clock, emulsification pot stirring 30rpm is then adjusted again, opens and the 40rpm stirrings of emulsification pot is adjusted after high speed homogenization emulsifies 6 minutes, insulated and stirred 5 is divided
Zhong Houkai is cooled down, and is kept stirring for speed 40rpm；
63~65 DEG C open low speed emulsifying simultaneously by C phases (C must be stirred in advance again before being added to) at a slow speed
Add and (reduce C phases as far as possible to be lost), C stops emulsifying after being added to, 40rpm stirring coolings, vacuumize；
Prefabricated D phases are added with 800 mesh cleaning filter-cloth filterings at 48~50 DEG C, 35rpm stirring coolings, vacuumized；
43~45 DEG C are added to prefabricated E, 35rpm stirring coolings, vacuumize；
40 DEG C are stopped cooling down, and sequentially add each material of F phases, adjust mixing speed to vacuumize, stir 5 minutes to 30rpm；
Finally G is added to, 30rpm stirs 8 minutes or more to stirring；
Censorship, qualified back observation side discharging, is made anti-apolexis composition.
Component and its parts by weight in above-mentioned anti-apolexis composition in each thing phase is as shown in table 1.
Table 1
Embodiment 2
Preparation method is identical with above-described embodiment 1, and the component and its content in each thing phase are as shown in table 1.
Embodiment 3
Preparation method is identical with above-described embodiment 1, and the component and its content in each thing phase are as shown in table 1.
Embodiment 4
Preparation method is identical with above-described embodiment 1, and the component and its content in each thing phase are as shown in table 1.
Comparative example 1
Preparation method is identical with above-described embodiment 1, and the component and its content in each thing phase are as shown in table 1.
Because DPHP, hydroxypropyl cyclodextrin are respectively provided with the effect of anti-aging, in commercially available anti-ageing aging
Also both materials are added with cosmetic, therefore, in this comparative example add DPHP, hydroxypropyl cyclodextrin replaces
The anti-aging factor of the generation present invention.
Comparative example 2
Preparation method is identical with above-described embodiment 1, and the component and its content in each thing phase are as shown in table 1.
Comparative example 3
Preparation method is identical with above-described embodiment 1, and the component and its content in each thing phase are as shown in table 1.
Comparative example 4
Preparation method is identical with above-described embodiment 1, and the component and its content in each thing phase are as shown in table 1.
In order to verify the present invention anti-apolexis composition whether being irritating to the skin property, choose above-described embodiment 1 sample
Test its security.
Method of testing：Female subjects of 24 ages between 18~40 years old are selected, wherein 13 subjects are sensitivity
Property skin (10 oiliness sensitiveness skin, 5 neutral sensitiveness skin and 5 dryness sensitiveness skin), 11 is non-quick
Perceptual skin (4 oily skins, 3 neutral skin and 4 dry skins) carries out integrated test.The right finesse of subject is
Blank control；Take appropriate amount of sample to be applied to the left finesse of every subject and massaged, wait to fully absorb, use daily
Once, it is used continuously 28 days, then carries out the security test result point of contrast scoring, sensitiveness skin and non-sensibility skin
2-1, table 2-2 are not shown in Table：
Table 2-1
Table 2-2
Can be seen that from table 1-1, table 1-2 will not produce any stimulation using the sample of the present invention to skin.Embodiment 2
~4 and the security test result of comparative example 1~4 and the secure sample test result of embodiment 1 it is identical, herein not
Repeat again.
The secure sample test result of comparative example 2 is similar to the secure sample test result of comparative example 1, also can be to portion
Divide the subject of sensitiveness skin to produce a certain degree of allergic reaction, will not be repeated here.
In order to verify whether the anti-apolexis composition of the present invention meets hygienic practice, by above-described embodiment 1~4, comparative example 1
~4 sample send third party authority testing agency to detect, and the test result of 8 samples is as shown in table 3：
Table 3
The result shows that inventive samples meet the monitoring of hygiene standard of GB/T26516-2011 cosmetics.
Moisten moistening effect test：
Human experimentation：The Subject Population's composition test population for voluntarily participating in experiment is chosen, test subject uses the present invention
Sample before and after moisture of skin and moisture loss change, so that it is determined that the moisture-keeping efficacy of sample.Using Corneometer
CM82 5 tests moisture content of skin；Scattered and disappeared moisture through skin using Tewameter TM300 tests.Moisture of skin relative increase rate
Fig. 1, Fig. 2 are seen respectively with the test result of relative percentage of water loss.
It was found from Fig. 1, Fig. 2, recipient site smeared the embodiment of the present invention 1~4, the sample of comparative example 1~4 after 1 hour, sample
Product group relative moisture rate of change be on the occasion of, be in 4 hours on the occasion of, but use embodiment 1~4 sample after relative moisture
Rate of change is far above comparative example 1, and wheat malt germ extract, soybean germ extract, safflower are comprised only in anti-apolexis composition
During a kind of germ extracts in germ extracts, obtained anti-apolexis composition sample is used to test, the relative water of skin
Divide rate of change to be relatively low, illustrate that the instant and long-acting moistening effect of the anti-apolexis composition of the present invention is very good.
Anti-aging effects are tested：
Testing in vitro：
Tester：Enzyme micro-plate reader RT6000 (Lei Du companies of the U.S.)
Method of testing：Before embodiment 1~4, the sample of comparative example 1~4 being used using the test of double-antibody sandwich ABC-ELISA methods
Fibroblastic Collagen I concentration (microgram) in exponential phase afterwards, the result of variations of Collagen I concentration
See Fig. 3.
As can be seen from Figure 3, fibroblast is used for using the sample of embodiment 1~4, uses front and rear Collagen I concentration
Changing value reaches more than 200 micrograms, and uses the changing value of the Collagen I concentration after the sample of comparative example 1 micro- less than 100
Gram, and one in wheat malt germ extract, soybean germ extract, safflower germ extracts is comprised only in the anti-apolexis composition
During kind extract, obtained anti-apolexis composition sample is used to test, and the changing value of Collagen I concentration is relatively low,
The anti-apolexis composition of this explanation present invention can largely promote Collagen I synthesis, so that the present invention
Anti-apolexis composition has splendid anti-aging effects.
When maize germ extract is comprised only in anti-apolexis composition, obtained anti-apolexis composition sample is used for anti-ageing
Old measure of merit, test result is very close with comparative example 4, will not be repeated here.
The anti-apolexis composition of the present invention is in addition to it can promote Collagen I to synthesize, moreover it is possible to promote CollagenIII
Synthesis and effectively remove free radical, will not be repeated here.
Above example is only used for the method detailed for illustrating the present invention, the invention is not limited in above-mentioned method detailed, i.e.,
Do not mean that the present invention has to rely on above-mentioned method detailed and could implemented.Person of ordinary skill in the field is it will be clearly understood that right
Any improvement of the present invention, addition, the selection of concrete mode of equivalence replacement and auxiliary element to each raw material of product of the present invention
Deng within the scope of all falling within protection scope of the present invention and disclosing.
Claims (26)
1. a kind of anti-apolexis composition, it is characterised in that comprising basic components and be scattered in anti-ageing in the basic components
The old factor, the anti-aging factor include soybean germ extract and wheat malt germ extract, in addition to safflower germ extracts
And/or maize germ extract；
By weight, the anti-apolexis composition includes 5~15 parts of anti-aging factors, wherein, the anti-aging factor
It is made up of soybean germ extract, wheat malt germ extract, safflower germ extracts, the soybean germ extract, wheat
Bud extract, the weight ratio of safflower germ extracts are (1~6):(1~3):(1~3)；
Or,
The anti-aging factor is carried by the anti-aging factor by soybean germ extract, wheat malt germ extract, maize germ
Thing is taken to form, the soybean germ extract, wheat malt germ extract, the weight ratio of maize germ extract are (1~6):(1
~3):(1~3).
2. anti-apolexis composition according to claim 1, it is characterised in that the basic components include emulsifying agent.
3. anti-apolexis composition according to claim 2, it is characterised in that by weight, the emulsifying agent includes 2.8
~4 parts of cetostearyl alcohols and 0.7~1 part of PEG-20 stearate.
4. anti-apolexis composition according to claim 3, it is characterised in that the cetostearyl alcohol and the PEG-20 are hard
The weight ratio of resin acid ester is 4:1.
5. anti-apolexis composition according to claim 3, it is characterised in that by weight, the emulsifying agent also includes
1.2~6 parts of cetostearyl alcohol olive oleates and the smooth olive oleate of 0.8~4 portion of sorb.
6. anti-apolexis composition according to claim 5, it is characterised in that the cetostearyl alcohol olive oleate and institute
The weight ratio for stating the smooth olive oleate of sorb is (1~3):(1~2).
7. anti-apolexis composition according to claim 6, it is characterised in that the cetostearyl alcohol olive oleate and institute
The weight ratio for stating the smooth olive oleate of sorb is 3:2.
8. anti-apolexis composition according to claim 3, it is characterised in that by weight, the emulsifying agent also includes
0.02~0.25 part of polysorbate -20 and 0.015~0.2 part of smooth isostearate of sorb.
9. anti-apolexis composition according to claim 1, it is characterised in that the basic components also include thickener.
10. anti-apolexis composition according to claim 9, it is characterised in that by weight, the thickener includes
0.4~1 part of docosyl alcohol, 0.25~1 part of cetostearyl alcohol, 0.12~1 part of acrylamide dimethyltaurine ammonium/docosyl alcohol gather
The methacrylic acid copolymer of ether -25 and 0.2~3 part of polyacrylate -13.
11. anti-apolexis composition according to claim 1, it is characterised in that the basic components also include emollient.
12. anti-apolexis composition according to claim 11, it is characterised in that by weight, the emollient includes 1
~5 parts of tristearins, 0.5~3 part of cetanol palmitate, 7~10 parts of caprylic/capric triglycerides, 6.7~15 parts different 16
Alkane.
13. anti-apolexis composition according to claim 1, it is characterised in that the basic components also include NMF.
14. anti-apolexis composition according to claim 13, it is characterised in that by weight, the NMF includes 1
~5 parts of dipropylene glycols, 0.5~2 part of glycerine, 0.12~1.5 part of polyisobutene, 5~15 parts of butanediols.
15. anti-apolexis composition according to claim 1, it is characterised in that the basic components also comprising preservative and
Anti-corrosive aids.
16. anti-apolexis composition according to claim 15, it is characterised in that by weight, the preservative includes
0.2~0.9 part of Phenoxyethanol, 0.01~0.06 part of iodine propilolic alcohol butyl mephenesin Carbamate and 0.004~0.8 part of methyl-isothiazol
Quinoline ketone.
17. anti-apolexis composition according to claim 15, it is characterised in that by weight, the anti-corrosive aids bag
Containing 0.02~0.1 part of Sensiva SC50 and 0.2~1 part of propane diols.
18. anti-apolexis composition according to claim 1, it is characterised in that the basic components also include conditioner.
19. anti-apolexis composition according to claim 18, it is characterised in that by weight, the conditioner includes
2.5~5 parts of dimethyl silicone polymers, 1~5 part of phenyl trimethicone, 2.5~10 parts of glycine betaines and 0.2~5 part are poly-
Vinylpyrrolidone.
20. anti-apolexis composition according to claim 1, it is characterised in that by weight, the basic components are also wrapped
Containing 0.1~1 part of pigment, 0.03~1 part of essence and 40~50 parts of deionized waters.
21. the preparation method of any one of a kind of claim 1 to 20 anti-apolexis composition, it is characterised in that described in offer
Basic components and the anti-aging factor；The basic components and the anti-aging factor are well mixed, are made described anti-ageing
Old composition.
22. a kind of preparation method of anti-apolexis composition, it is characterised in that comprise the steps of：
(1) by weight by 1~5 part of dipropylene glycol, 0.5~2 part of glycerine, 2.5~10 parts of glycine betaines and 40~47 parts go from
Sub- water is well mixed, and the first mixture is made, and 0.12~1 part of acrylamide dimethyl ox sulphur is added into first mixture
Sour ammonium/the methacrylic acid copolymer of docosyl alcohol polyethers -25,5~15 parts of anti-aging factors are added after being well mixed, it is mixed to be made second
Compound；
(2) by 2.8~4 parts of cetostearyl alcohols and mixture, 1.2~6 parts of spermaceti of 0.7~1 part of PEG-20 stearates composition
The mixture of stearyl alcohol olive oleate and the smooth olive oleate composition of 0.8~4 portion of sorb, 0.4~1 part of docosyl alcohol, 0.25~1
Part cetostearyl alcohol, 1~5 part of tristearin, 0.5~3 part of cetanol palmitate, 2.5~5 parts of dimethyl silicone polymers, 7~
10 parts of caprylic/capric triglycerides, 3~5 parts of phenyl trimethicones and 5.5~10 parts of isohexadecanes are well mixed simultaneously
Melt completely, the 3rd mixture is made；
3rd mixture is added in second mixture, the 4th mixture is made；
(3) successively will be by 0.2~3 part of polyacrylate -13,0.12~1.5 part of polyisobutene, 0.02~0.25 part of polysorbate
Ester -20, the smooth isostearate of 0.015~0.2 portion of sorb, 0.02~0.25 part of deionized water and 1.2~5 parts of isohexadecane groups
Into mixture, the mixture being made up of 0.2~5 part of polyvinylpyrrolidone, 4~10 parts of butanediols, by 0.2~0.9 part of benzene
Oxyethanol, 0.02~0.1 part of Sensiva SC50,0.01~0.06 part of iodine propilolic alcohol butyl mephenesin Carbamate, 0.2~1 part the third two
The mixture of alcohol and 1~5 part of butanediol composition, by 0.004~0.8 part of methylisothiazolinone, 0.1~1 part of pigment and
In the mixture and 0.03~1 part of essence addition the 4th mixture of 0.05~1 part of deionized water composition, it is made described anti-
Anti-aging composition；
Wherein, the anti-aging factor includes soybean germ extract and wheat malt germ extract, in addition to the extraction of safflower plumule
Thing and/or maize germ extract；
By weight, the anti-apolexis composition includes 5~15 parts of anti-aging factors, wherein, the anti-aging factor
It is made up of soybean germ extract, wheat malt germ extract, safflower germ extracts, the soybean germ extract, wheat
Bud extract, the weight ratio of safflower germ extracts are (1~6):(1~3):(1~3)；
Or,
The anti-aging factor is carried by the anti-aging factor by soybean germ extract, wheat malt germ extract, maize germ
Thing is taken to form, the soybean germ extract, wheat malt germ extract, the weight ratio of maize germ extract are (1~6):(1
~3):(1~3)；
Wherein, in the mixture of 2~10 parts of cetostearyl alcohol olive oleates and the smooth olive oleate of sorb, the spermaceti
The weight ratio of stearyl alcohol olive oleate and the smooth olive oleate of the sorb is (1~3):(1~2).
23. preparation method according to claim 22, it is characterised in that 3.5~5 parts of cetostearyl alcohols and PEG-20
In the mixture of stearate, the weight ratio of the cetostearyl alcohol and the PEG-20 stearates is 4:1.
24. preparation method according to claim 22, it is characterised in that sweet by double third successively by weight in step (1)
Alcohol, glycerine, glycine betaine and deionized water are added in emulsifying pot, and the first mixture, processing condition are made after emulsifying
Acrylamide dimethyltaurine ammonium/methacrylic acid of docosyl alcohol polyethers -25 is slowly added in descending toward first mixture to be total to
Polymers, the emulsifying 5min under 40rpm mixing speeds, the anti-aging factor is added after well mixed, speed is stirred in 40rpm
85~88 DEG C are warming up under degree and is incubated, the second mixture is made.
25. preparation method according to claim 24, it is characterised in that successively that spermaceti is hard by weight in step (2)
Lipidol and mixture, cetostearyl alcohol olive oleate the olive oleate composition smooth with sorb of PEG-20 stearates composition
Mixture, docosyl alcohol, cetostearyl alcohol, tristearin, cetanol palmitate, dimethyl silicone polymer, caprylic/capric glycerine
Three esters, phenyl trimethicone and isohexadecane add stirring in oil phase pot and are warming up to 80~83 DEG C to melting completely,
The 3rd mixture is made；
Second mixture is stirred with 50rpm mixing speed, and by described in the 3rd mixture addition in oil phase pot
In second mixture, the emulsifying 6min under 30rpm mixing speeds, 5min is then stirred under 40rpm mixing speeds, cooled down
40rpm mixing speeds are kept afterwards, and the 4th mixture is made.
26. preparation method according to claim 22, it is characterised in that step (3) specifically comprises the steps of：
(3a) will be smooth by polyacrylate -13, polyisobutene, polysorbate -20, sorb under 63~65 DEG C, processing condition
The mixture of isostearate, deionized water and isohexadecane composition is slowly added in the 4th mixture, 40rpm stirrings
Stir under speed, vacuumized after cooling, the 5th mixture is made；
Then (3b) polyvinylpyrrolidone adds with using 800 mesh filter-cloth filterings after butanediol premix under the conditions of 48~50 DEG C
Enter in the 5th mixture, stir under 35rpm mixing speeds, vacuumized after cooling, the 6th mixture is made；
After (3c) Phenoxyethanol, Sensiva SC50, iodine propilolic alcohol butyl mephenesin Carbamate, propane diols and butanediol premix,
43~45 DEG C add in the 6th mixture, stir under 35rpm mixing speeds, are vacuumized after cooling, and the 7th mixture is made；
(3d) adds methylisothiazolinone, pigment and deionized water in the 7th mixture at 40 DEG C, 30rpm stirrings
5min is stirred under speed and is vacuumized, the 8th mixture is made；
(3e) adds essence in the 8th mixture, is stirred under 30rpm mixing speeds, and the anti-aging combination is made
Thing.
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| CN106074279A (en) * | 2016-07-11 | 2016-11-09 | 广州丹奇日用化工厂有限公司 | A kind of anti-ageing facial cream containing Herba Artemisiae montanae Artemisia extract and preparation method thereof |
| CN107149582A (en) * | 2017-05-13 | 2017-09-12 | 佛山文森特知识产权服务有限公司 | A kind of anti-apolexis composition and its application |
| CN107898721B (en) * | 2017-11-30 | 2021-01-12 | 丸美化妆品株式会社 | Skin-care matrix and application thereof |
| CN107982177A (en) * | 2017-12-27 | 2018-05-04 | 广州爱韵生物科技有限公司 | Fine flour film is moistened in wheat embryo moisturizing |
| CN109527587A (en) * | 2019-01-03 | 2019-03-29 | 拓普河北生物科技有限公司 | A kind of collagen Gly-His-Lys and preparation method thereof with senile-resistant efficacy |
| CN110934787B (en) * | 2019-11-27 | 2022-04-19 | 陈少威 | Anti-aging composition and preparation method thereof |
| CN111956569A (en) * | 2020-07-17 | 2020-11-20 | 重庆珂蓝健康管理集团有限公司 | Rejuvenating and anti-aging composite material and application thereof |
| CN112353722A (en) * | 2020-11-19 | 2021-02-12 | 广州上悦生物科技有限公司 | Moisturizing anti-aging repairing composition and preparation method and application thereof |
| CN112545955B (en) * | 2020-12-17 | 2022-10-28 | 广州环亚化妆品科技股份有限公司 | Anti-aging repair composition and preparation method and application thereof |
| CN113952253B (en) * | 2021-09-27 | 2023-07-25 | 水羊化妆品制造有限公司 | Composition for improving stability of cosmetics, cosmetics containing composition and preparation method of composition |
| CN115844794A (en) * | 2022-12-19 | 2023-03-28 | 羽楠(广州)化妆品有限公司 | Anti-aging composition, cosmetic containing anti-aging composition and application of cosmetic |
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|---|---|---|---|---|
| CN100441555C (en) * | 2004-04-09 | 2008-12-10 | 汪云 | Composition containing resveratrol and soybean isoflavone and its preparation and use |
| CN102397226A (en) * | 2011-11-15 | 2012-04-04 | 吴桂标 | Anti-wrinkle cream |
| CN104083317B (en) * | 2014-06-27 | 2016-03-30 | 郑州市嘉蓓丽生物科技有限公司 | A kind of white young tea leaves eye-care frost and preparation method thereof |
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2015
- 2015-08-18 CN CN201510509228.8A patent/CN105030610B/en active Active
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Denomination of invention: Anti-aging composition and preparation method thereof Effective date of registration: 20191226 Granted publication date: 20180316 Pledgee: China Co truction Bank Corp Guangzhou green finance reform and innovation pilot area Huadu Branch Pledgor: GUANGDONG ESSENCE BIOTECHNOLOGY CO., LTD. Registration number: Y2019440000320 |
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